AIDS-RELATED MALIGNANT B-CELL LYMPHOMAS NLM AIDSLINE Important note: Information in this article was accurate in 1989. The state of the art may have changed since the publication date.

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AIDS-RELATED MALIGNANT B-CELL LYMPHOMAS

AIDS: Modern Concepts and Therapeutic Challenges. Broder S, ed. New York, Marcel Dekker, p. 233-44, 1987.. Unique Identifier : AIDSLINE ICDB/89650445
Levine AM; Gill PS; Rasheed S; Dept. of Internal Medicine, Univ. of Southern California Sch. of; Medicine, Los Angeles, CA

Abstract: The precise nature of AIDS-related lymphomas is discussed based on the authors' experience treating 44 men (42 homosexual or bisexual) with malignant lymphoma. An evaluation of the clinical, pathological, immunological, and virological features of the disease was conducted in these patients (pts) to elucidate the factors that serve to define the AIDS-related lymphoma. The malignant lymphomas associated with AIDS are quite distinctive, pathologically and clinically. They may be defined best as high-grade B-cell lymphomas that present in disseminated fashion in unusual extranodal sites such as the CNS or rectum. They are associated with the reversal in the T4:T8 ratio in the peripheral blood, as well as exposure to human T-lymphotropic virus-III/lymphadenopathy-associated virus and distant exposure to the Epstein-Barr virus. Results of treatment using standard intensive multiagent chemotherapy have been disappointing, with median survival of less than 1 yr in treated pts. CNS relapse may occur despite attempts at prophylactic therapy. The precise mechanism of development of lymphoma in these pts remains to be defined. (33 Refs)
Keywords: Acquired Immunodeficiency Syndrome/*COMPLICATIONS/IMMUNOLOGY/ PATHOLOGY Adult Aged Antibodies, Viral/ANALYSIS *B-Lymphocytes/IMMUNOLOGY/PATHOLOGY Follow-Up Studies Herpesvirus 4, Human/IMMUNOLOGY Homosexuality Human HIV/IMMUNOLOGY/*PATHOGENICITY HIV Antibodies/ANALYSIS Lymphoma/*ETIOLOGY/IMMUNOLOGY/PATHOLOGY Male Middle Age Risk Factors MONOGRAPH

KWDacquiredimmunodeficiencysyndrome/KWDcomplications/immunology/pathologyadultagedantibodies,viral/analysisKWDb-lymphocytes/immunology/pathologyfollow-upstudiesherpesvirus4,human/immunologyhomosexualityhumanhiv/immunology/KWDpathogenicityhivantibodies/analysislymphoma/KWDetiology/immunology/pathologymalemiddleageriskfactorsmonograph
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Copyright © 1989 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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