DERMATOLOGICAL (NON-KAPOSI'S SARCOMA) MANIFESTATIONS ASSOCIATED WITH HTLV-III/LAV INFECTION NLM AIDSLINE Important note: Information in this article was accurate in 1989. The state of the art may have changed since the publication date.

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DERMATOLOGICAL (NON-KAPOSI'S SARCOMA) MANIFESTATIONS ASSOCIATED WITH HTLV-III/LAV INFECTION

AIDS: Modern Concepts and Therapeutic Challenges. Broder S, ed. New York, Marcel Dekker, p. 285-302, 1987.. Unique Identifier : AIDSLINE ICDB/89650447
Resnick L; Herbst JS; Retrovirology Laboratories, Dept. of Dermatology, Mt. Sinai; Medical Center, Miami Beach, FL

Abstract: Dermatological manifestations associated with human T-lymphotropic virus-III/lymphadenopathy-associated virus (HTLV-III/LAV) can be classified into three categories--infections, malignancies, and miscellaneous cutaneous eruptions--each of which is reviewed here. Mucocutaneous infections, which are extremely difficult to treat and have a high recurrence rate, can result from viruses, fungi, protozoa, bacteria, and mycobacteria. All result from impaired host immunity. Malignancies include Hodgkin's and non-Hodgkin's lymphomas and various squamous cell and cloacogenic anorectal carcinomas. Cutaneous drug-induced eruptions are frequently seen in patients (pts) receiving sulfonamides during therapy for Pneumocystis carinii pneumonia or toxoplasmosis. Other sources of skin manifestations are primary HTLV-III/LAV infection, seborrheic dermatitis, oral hairy leukoplakia, and granuloma annulare-like eruption. Thorough dermatological assessments at regular intervals are an important part of the management of pts with HTLV-III/LAV disease. When present in pts at high risk for HTLV-III/LAV infection (homosexual men, iv drug addicts, hemophiliacs), these dermatological disorders should alert the clinician to the possible diagnosis of an HTLV-III/LAV-associated disorder. (35 Refs)
Keywords: Acquired Immunodeficiency Syndrome/*COMPLICATIONS Drug Eruptions/COMPLICATIONS Human HIV/*PATHOGENICITY Opportunistic Infections/*COMPLICATIONS Sarcoma, Kaposi's/*ETIOLOGY Skin Diseases/*COMPLICATIONS Skin Diseases, Infectious/COMPLICATIONS Skin Neoplasms/COMPLICATIONS/*ETIOLOGY MONOGRAPH REVIEW REVIEW, TUTORIAL

KWDacquiredimmunodeficiencysyndrome/KWDcomplicationsdrugeruptions/complicationshumanhiv/KWDpathogenicityopportunisticinfections/KWDcomplicationssarcoma,kaposi's/KWDetiologyskindiseases/KWDcomplicationsskindiseases,infectious/complicationsskinneoplasms/complications/KWDetiologymonographreviewreview,tutorial
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Copyright © 1989 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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