Important note: Information in this article was accurate in 1989. The state of the art may have changed since the publication date.
CLINICAL ASPECTS OF INFECTION WITH THE AIDS RETROVIRUS: ACUTE HIV INFECTION, PERSISTENT GENERALIZED LYMPHADENOPATHY, AND AIDS-RELATED COMPLEX
AIDS: Etiology, Diagnosis, Treatment, and Prevention. Second Edition. DeVita VT Jr et al, eds. Philadelphia, Lippincott, p. 107-20, 1988.. Unique Identifier : AIDSLINE ICDB/89650903 Yarchoan R; Pluda JM; Clinical Oncology Program, Div. of Cancer Treatment, NCI,; Bethesda, MD
Abstract:
It is now recognized that HIV can (either directly or indirectly) affect nearly every organ system in the body and that a wide range of clinical manifestations can result from infection with this agent. Some of these appear to result directly from infection with the virus while others may result from the altered immune function in infected patients and the resulting opportunistic infections or change in normal flora. Clinical presentations of HIV infection are described, with emphasis on some of the early and less severe disease manifestations. Topics discussed include classification of HIV-associated disease, acute illness associated with HIV seroconversion, asymptomatic HIV infection and persistent generalized lymphadenopathy, AIDS-related complex (ARC), hematologic manifestations of HIV infection, cutaneous and oral manifestations of HIV infection, and ocular complications of HIV infection. HIV infection may have many clinical manifestations, ranging from an asymptomatic state to devastating multisystem illness. As the incidence of this disease increases, it is likely that new manifestations attributable to HIV will be seen. Many of the persons infected with HIV, but not defined as having AIDS, will have some symptoms attributable to their infection, and many others will have substantial symptoms that may interfere with their daily lives and even prevent them from working. Therefore, effective therapy is needed, not only for persons with frank AIDS, but for those with less advanced disease. In such patients, therapy should be evaluated not only for its ability to prevent the development of AIDS, but for its ability to reduce the existing symptomatology. (123 Refs)
Keywords: Acquired Immunodeficiency Syndrome/COMPLICATIONS/IMMUNOLOGY/ *MICROBIOLOGY AIDS-Related Complex/IMMUNOLOGY/*MICROBIOLOGY Follow-Up Studies Human HIV/IMMUNOLOGY/*PATHOGENICITY HIV Antigens/IMMUNOLOGY HIV Seropositivity/IMMUNOLOGY Leukoplakia, Oral/ETIOLOGY Opportunistic Infections/COMPLICATIONS Sarcoma, Kaposi's/ETIOLOGY Skin Neoplasms/ETIOLOGY MONOGRAPH REVIEW REVIEW, TUTORIAL
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Important note: Information in this article was accurate in 1989. The state of the art may have changed since the publication date.
