[Neuropathologic study of 15 cases of multinucleated giant cell encephalitis in acquired immunodeficiency syndrome (AIDS)] NLM AIDSLINE Important note: Information in this article was accurate in 1989. The state of the art may have changed since the publication date.

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[Neuropathologic study of 15 cases of multinucleated giant cell encephalitis in acquired immunodeficiency syndrome (AIDS)]

Ann Pathol. 1988;8(4-5):281-9. Unique Identifier : AIDSLINE MED/89105199
Gray F; Fenelon G; Gherardi R; Favolini M; Goulon M; Guillard A; Poirier J; Departement de Pathologie Tissulaire et Cellulaire, Hopital; Henri Mondor, Creteil.

Abstract: The central nervous system (CNS) of 40 patients who died of acquired immune deficiency syndrome (AIDS) between August 1982 and August 1987 was examined. In 15 cases, multinucleated giant cells (MGC) characteristic of Human Immunodeficiency Virus (HIV) infection were observed. In 3 cases ultrastructural examination disclosed HIV-like viral particles in the cytoplasm of some MGC. All cases with MGC showed, in addition, predominant white matter lesion: diffuse myelin pallor, multiple small, usually subcortical, necrotic foci, vacuolar myelopathy, proliferation of rod-shade microglia and microglial nodules, reactive astrocytosis, mineralization of the vessel walls. These changes, typical of HIV encephalitis, were isolated in 3 cases. In the other cases, they were associated with other AIDS-related CNS lesions, i.e., cerebral toxoplasmosis (9 cases), cytomegalovirus infection (5 cases), progressive multifocal leukoencephalitis (1 case), cryptococcosis (1 case) and cerebral lymphoma (1 case). The involvement of MGC with these lesions was remarkable.
Keywords: Acquired Immunodeficiency Syndrome/COMPLICATIONS/*PATHOLOGY Adult Aged Brain/MICROBIOLOGY/*PATHOLOGY/ULTRASTRUCTURE Encephalitis/ETIOLOGY/MICROBIOLOGY/*PATHOLOGY English Abstract Human Male Middle Age JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/complications/KWDpathologyadultagedbrain/microbiology/KWDpathology/ultrastructureencephalitis/etiology/microbiology/KWDpathologyenglishabstracthumanmalemiddleagejournalarticle
890530
M8950653

Copyright © 1989 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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