(Producer) A new program on the latest recommendations by The Center for Disease Control and how to apply them specifically to the radiology department. The epidemiology modes of transmission and prevention of HIB infection are explained along with very detailed safety precautions, making this program essential view
[Bethesda, Md.] : U.S. Dept. of Health and Human Services, Public Health Service, National Institutes of Health, [1986] 42 p (Literature search / National Library of Medicine ; no. 86-9) Unique Identifier : AIDSLINE CAT/8904606
San Francisco, Calif. (225 30th St., San Francisco 94131) : AIDS Home Care and Hospice Program, VNA of San Francisco, c1987 195 p. : ill., ports Unique Identifier : AIDSLINE CAT/8905941
[Saint Louis, Mo. (3700 Lindell Blvd., Saint Louis 63108) : Saint Louis University School of Law, c1988] 226 p (Saint Louis University public law review ; v. 7, no. 1) Unique Identifier : AIDSLINE CAT/8905150
AIDS: Modern Concepts and Therapeutic Challenges. Broder S, ed. New York, Marcel Dekker, 369 p., 1987.. Unique Identifier : AIDSLINE ICDB/89650434
Anonymous; No affiliation given
Molecular, biological, epidemiological, psychosocial, and clinical features of AIDS and its related diseases are reviewed. Chapters cover the following topics: the biological basis of adult T-cell leukemia/lymphoma and AIDS (human T-lymphotropic retroviruses [HTLV-I, II, and III]), lymphadenopathy/AIDS virus as the pr
Retroviruses in relation to leukemia and AIDS are reviewed under the following headings: general biology of retroviruses, general features of human retroviruses, characteristics of leukemic cells and of the disease associated with human T-lymphotropic virus HTLV-I, origin and spread of HTLV-I and epidemiology of adult
AIDS: Modern Concepts and Therapeutic Challenges. Broder S, ed. New York, Marcel Dekker, p. 23-37, 1987.. Unique Identifier : AIDSLINE ICDB/89650436
Wain-Hobson S; Sonigo P; Alizon M; Montagnier L; Unite de Recombinaison et Expression Genetique, Institut Pasteur,; Paris, France
The virology of lymphadenopathy/human T-lymphotropic virus (LAV/HTLV-III) and the relationship of this virus to the animal lentiviruses are reviewed, including the elements making up the viral genome, evidence that the AIDS virus is a lentivirus, relevance of visna to AIDS, and prospects of handling lentiviral disease
AIDS: Modern Concepts and Therapeutic Challenges. Broder S, ed. New York, Marcel Dekker, p. 39-52, 1987.. Unique Identifier : AIDSLINE ICDB/89650437
Wong-Staal F; Lab. of Tumor Cell Biology, NCI, Bethesda, MD
Genetic aspects of human T-lymphotropic virus (HTLV) are reviewed as they relate to infection of human hosts. Topics include genetic structures of HTLV-I, -II, and -III; assembling the genes for transactivation; transcriptional regulation of cellular genes by HTLV-I and -II leading to immortality; viral and cellular f
AIDS: Modern Concepts and Therapeutic Challenges. Broder S, ed. New York, Marcel Dekker, p. 53-62, 1987.. Unique Identifier : AIDSLINE ICDB/89650438
Haseltine WA; Sodroski JG; Rosen CA; Lab. of Biochemical Pharmacology, Dana-Farber Cancer Inst.,; Boston, MA
The molecular biology of human T-lymphotropic virus (HTLV)-III is reviewed and unanswered questions are discussed. Topics include gag, pol, and env genes; features of HTLV-III that account for some of the unusual features of the virus life cycle and disease; sor, tat, and 3 orf genes; the role of tat-coded proteins in
AIDS: Modern Concepts and Therapeutic Challenges. Broder S, ed. New York, Marcel Dekker, p. 91-121, 1987.. Unique Identifier : AIDSLINE ICDB/89650440
Biggar RJ; International AIDS Epidemiology, Environmental Epidemiology; Branch, NCI, Bethesda, MD
Human retroviruses are reviewed under the following headings: history and nomenclature, serology, human T-lymphotropic virus (HTLV)-I (epidemiology of clinically related conditions, and seroepidemiology), HTLV-II, and HTLV-III and AIDS (epidemiology of clinically related conditions, surveillance and registry data, ris
AIDS: Modern Concepts and Therapeutic Challenges. Broder S, ed. New York, Marcel Dekker, p. 135-42, 1987.. Unique Identifier : AIDSLINE ICDB/89650441
Groopman JE; Div. of Hematology/Oncology, Dept. of Medicine, New England; Deaconess Hosp., Boston, MA
Diseases related to human T-lymphotropic virus/lymphadenopathy-associated virus (HTLV-III/LAV) other than full-blown AIDS are discussed. The spectrum of disease consequent to retroviral infection includes AIDS-related complex (ARC), including lymphadenopathy, herpes zoster and oral candidiasis infection, diarrhea, hem
AIDS: Modern Concepts and Therapeutic Challenges. Broder S, ed. New York, Marcel Dekker, p. 143-84, 1987.. Unique Identifier : AIDSLINE ICDB/89650442
Jaffe ES; Katz DA; Macher AM; Hematopathology Section, Lab. of Pathology, NCI, Bethesda, MD
Pathological manifestations associated with AIDS are described, including the following: lymphoid and hematological lesions, opportunistic infections (protozoa, viruses, fungi, and bacteria), malignancies (Kaposi s sarcoma, non-Hodgkin s lymphoma , Hodgkin s disease, small cell carc
AIDS: Modern Concepts and Therapeutic Challenges. Broder S, ed. New York, Marcel Dekker, p. 205-18, 1987.. Unique Identifier : AIDSLINE ICDB/89650443
Safai B; Dermatology Service, Dept. of Medicine, Memorial Sloan-Kettering; Cancer Center, New York, NY
Kaposi s sarcoma (KS) is reviewed under the following headings: history, epidemiology (incidence and sex, age and racial distribution), clinical manifestations and course of the disease, histopathology, associated diseases, and histogenesis. Prior to 1981, KS was considered a rare tumor that occurred in cluster distri
Kaposi s sarcoma (KS) associated with AIDS and human T-lymphotropic virus-III/lymphadenopathy-associated virus (HTLV-III/LAV) infection is reviewed. The occurrence of the disorder is restricted to four well-defined groups, in each of which KS appears to follow a different clinical course: (1) African KS (before the ad
AIDS: Modern Concepts and Therapeutic Challenges. Broder S, ed. New York, Marcel Dekker, p. 233-44, 1987.. Unique Identifier : AIDSLINE ICDB/89650445
Levine AM; Gill PS; Rasheed S; Dept. of Internal Medicine, Univ. of Southern California Sch. of; Medicine, Los Angeles, CA
The precise nature of AIDS-related lymphomas is discussed based on the authors experience treating 44 men (42 homosexual or bisexual) with malignant lymphoma. An evaluation of the clinical, pathological, immunological, and virological features of the disease was conducted in these patients (pts) to elucidate the fact
AIDS: Modern Concepts and Therapeutic Challenges. Broder S, ed. New York, Marcel Dekker, p. 285-302, 1987.. Unique Identifier : AIDSLINE ICDB/89650447
Resnick L; Herbst JS; Retrovirology Laboratories, Dept. of Dermatology, Mt. Sinai; Medical Center, Miami Beach, FL
Dermatological manifestations associated with human T-lymphotropic virus-III/lymphadenopathy-associated virus (HTLV-III/LAV) can be classified into three categories--infections, malignancies, and miscellaneous cutaneous eruptions--each of which is reviewed here. Mucocutaneous infections, which are extremely difficult
Development of screening systems for agents active against human T-lymphotropic virus-III/lymphadenopathy-associated virus (HTLV-III/LAV)-related diseases is described, and results are reported for the following: generation of an HTLV-III/LAV cytopathic effect-sensitive T-cell clone; anti-HTLV-III/LAV activities of 2
The rationale for the use of antiviral agents against human T-lymphotropic virus-III/lymphadenopathy-associated virus (HTLV-III/LAV) infection is discussed; a strategy is outlined that has been used to develop drugs with potential clinical application; and the status is reported of several drugs (suramin, 3 -azido-3 -
Dev Med Virol; 4:319-31 1988. Unique Identifier : AIDSLINE ICDB/89649864
Levy HB; Molecular Virology Section, Natl. Inst. of Allergy and Infectious; Diseases, NIH, Bethesda, MD 20982
Preclinical studies of polynucleotide use in rodents, immune modulating effects of polynucleotides in primates, including man, and clinical studies with various polynucleotides are reviewed. The clinical studies described employed polyadenylic:polyuridylic acid, in the adjuvant treatment of operable breast cancer, and
Kaposi's Sarcoma: Pathophysiology and Clinical Management. Ziegler JL, Dorfman RF, eds. New York, Marcel Dekker, p. 23-70, 1988.. Unique Identifier : AIDSLINE ICDB/89650410
Templeton AC; Dept. of Pathology, Rush Medical Coll., Presbyterian-St. Luke's; Medical Center, Chicago, IL
Classic histopathology of Kaposi s sarcoma (KS), its clinical subtypes, evolution of cutaneous KS, differential diagnosis, and distribution of lesions and their characteristics in different tissues are reviewed. Lesions of the skin, mouth and gastrointestinal tract, respiratory tract, lymph nodes, spleen, skeleton, li
Kaposi's Sarcoma: Pathophysiology and Clinical Management. Ziegler JL, Dorfman RF, eds. New York, Marcel Dekker, p. 129-50, 1988.. Unique Identifier : AIDSLINE ICDB/89650413
Penn I; Dept. of Surgery, Univ. of Cincinnati Medical Center, Cincinnati,; OH
The role of immunodeficiency in Kaposi s sarcoma (KS) is considered in four categories of patients (pts): (1) individuals with AIDS who have epidemic KS; (2) African pts with endemic KS; (3) organ transplant recipients with KS; and (4) immunosuppressed non-organ transplant pts with KS. Immunosuppression, as determined
Kaposi's Sarcoma: Pathophysiology and Clinical Management. Ziegler JL, Dorfman RF, eds. New York, Marcel Dekker, p. 237-48, 1988.. Unique Identifier : AIDSLINE ICDB/89650417
Harris JW; Berson AM; Reed TA; Wara WM; Dept. of Radiation Oncology, Sch. of Medicine, Univ. of; California, San Francisco, CA
Published data and the authors clinical experience are presented in a discussion of radiation therapy in patients (pts) with AIDS-associated Kaposi s sarcoma (KS). Topics include radiation therapy in nonepidemic KS; radiation therapy in epidemic KS, including specific treatment recommendations by site (cutaneous lesi
AIDS: Etiology, Diagnosis, Treatment, and Prevention. Second Edition. DeVita VT Jr et al, eds. Philadelphia, Lippincott, 474 p., 1988.. Unique Identifier : AIDSLINE ICDB/89650896
Anonymous; No affiliation given
This book attempts to provide a comprehensive source of information on all aspects of AIDS written by the clinicians and scientists who have made the central contributions to the field. Basic considerations, clinical aspects, and public health issues associated with AIDS are discussed. Specific topics covered include
AIDS: Etiology, Diagnosis, Treatment, and Prevention. Second Edition. DeVita VT Jr et al, eds. Philadelphia, Lippincott, p. 3-10, 1988.. Unique Identifier : AIDSLINE ICDB/89650897
Essex M; Dept. of Cancer Biology, Harvard Sch. of Public Health, Boston,; MA
AIDS was first described as a new and distinct clinical entity in 1981. The first cases were recognized because of unusual clustering of diseases such as Kaposi s sarcoma and Pneumocystis pneumonia in young homosexual men. The history of AIDS is summarized, including studies of the infectious etiology of AIDS, the ori
AIDS: Etiology, Diagnosis, Treatment, and Prevention. Second Edition. DeVita VT Jr et al, eds. Philadelphia, Lippincott, p. 33-60, 1988.. Unique Identifier : AIDSLINE ICDB/89650899
HIV is a sexual and blood-borne pathogen that infects and, in most persons, gradually destroys a critical component of immunity, the population of helper-inducer lymphocytes identified by the CD4+ (T4+) surface epitope. Because CD4+ cells coordinate the entire cellular immune response, HIV infections can have myriad m
AIDS: Etiology, Diagnosis, Treatment, and Prevention. Second Edition. DeVita VT Jr et al, eds. Philadelphia, Lippincott, p. 87-104, 1988.. Unique Identifier : AIDSLINE ICDB/89650902
Fischinger PJ; NCI, Bethesda, MD
Human AIDS is an expanding pandemic involving over 57,000 cases in the United States alone. As currently defined, clinical AIDS is generally lethal. Infection with the causative agent, HIV, is apparently irreversible. Current strategies of intervention are based on a few drugs of the c
AIDS: Etiology, Diagnosis, Treatment, and Prevention. Second Edition. DeVita VT Jr et al, eds. Philadelphia, Lippincott, p. 107-20, 1988.. Unique Identifier : AIDSLINE ICDB/89650903
Yarchoan R; Pluda JM; Clinical Oncology Program, Div. of Cancer Treatment, NCI,; Bethesda, MD
It is now recognized that HIV can (either directly or indirectly) affect nearly every organ system in the body and that a wide range of clinical manifestations can result from infection with this agent. Some of these appear to result directly from infection with the virus while others may result from the altered immun
AIDS: Etiology, Diagnosis, Treatment, and Prevention. Second Edition. DeVita VT Jr et al, eds. Philadelphia, Lippincott, p. 137-54, 1988.. Unique Identifier : AIDSLINE ICDB/89650905
Poiesz BJ; Ehrlich GD; Papsidero LD; Sninsky JJ; SUNY Health Science Center, Syracuse, NY
Strategies employing a variety of serologic assays to detect natural antibodies to the viral structural proteins are currently used to identify patients who have been exposed to human retroviruses and to exclude potentially infected blood products from being transfused. Although some of these techniques are suitable f
AIDS: Etiology, Diagnosis, Treatment, and Prevention. Second Edition. DeVita VT Jr et al, eds. Philadelphia, Lippincott, p. 155-83, 1988.. Unique Identifier : AIDSLINE ICDB/89650906
Macher AM; De Vinatea ML; Angritt P; Tuur SM; Reichert CM; Armed Forces Inst. of Pathology, Washington, DC
AIDS is a devastating new disease caused by the HIV, which renders the host profoundly immunoincompetent. The surgical and postmortem pathologic features associated with infection by HIV can be divided into four major categories: (1) morphologic manifestations of immunologic impairment; (2) secondary opportunistic inf
AIDS: Etiology, Diagnosis, Treatment, and Prevention. Second Edition. DeVita VT Jr et al, eds. Philadelphia, Lippincott, p. 185-97, 1988.. Unique Identifier : AIDSLINE ICDB/89650907
Brew B; Rosenblum M; Price RW; Memorial Sloan-Kettering Cancer Center, New York, NY
The neurologic complications of HIV infection, and particularly its late phase, AIDS, are both common and varied, and contribute importantly to patient (pt) morbidity and mortality. Both the CNS and peripheral nervous system (PNS) are affected by a spectrum of disorders, some of which can occur as early as the period
AIDS: Etiology, Diagnosis, Treatment, and Prevention. Second Edition. DeVita VT Jr et al, eds. Philadelphia, Lippincott, p. 227-44, 1988.. Unique Identifier : AIDSLINE ICDB/89650908
Bartlett JG; Laughon B; Quinn TC; Dept. of Medicine, Johns Hopkins Univ. Sch. of Medicine,; Baltimore, MD
HIV infection and its consequences on the immune defenses may ultimately affect every organ system. The gastrointestinal (GI) tract is one of the most common sites of clinical expression, and all levels from the oral cavity to the anus are frequently involved. A source of considerable concern is that many of these con
AIDS: Etiology, Diagnosis, Treatment, and Prevention. Second Edition. DeVita VT Jr et al, eds. Philadelphia, Lippincott, p. 245-61, 1988.. Unique Identifier : AIDSLINE ICDB/89650909
Krigel RL; Friedman-Kien AE; Fox Chase Cancer Center, Philadelphia, PA 19111
The recent epidemic of a disseminated, fulminant form of Kaposi s sarcoma (KS) was first observed among young homosexual men in large urban centers in the United States . This new form of KS shall be referred to as epidemic KS in light of its association with the AIDS and to distinguish
AIDS: Etiology, Diagnosis, Treatment, and Prevention. Second Edition. DeVita VT Jr et al, eds. Philadelphia, Lippincott, p. 263-75, 1988.. Unique Identifier : AIDSLINE ICDB/89650910
Levine AM; Univ. of Southern California Sch. of Medicine, Los Angeles, CA
Early in the AIDS epidemic, it became apparent that individuals at risk for AIDS were also at risk for development of generalized lymphadenopathy of a reactive nature. The term persistent generalized lymphadenopathy (PGL) was used to characterize this disorder, described as generalized lymphadenopathy involving at lea
AIDS: Etiology, Diagnosis, Treatment, and Prevention. Second Edition. DeVita VT Jr et al, eds. Philadelphia, Lippincott, p. 339-51, 1988.. Unique Identifier : AIDSLINE ICDB/89650913
Falloon J; Eddy J; Roper M; Pizzo PA; Clinical Center, NIH, Bethesda, MD
Soon after AIDS was recognized in homosexual males and iv drug abusers, cases of an immunodeficiency with similar features were observed in children. AIDS in children is discussed, including routes of transmission, definition of AIDS in children, diagnosis of HIV infection in children, clinical manifestations, classif
The Interferon System. A Current Review to 1987. Baron S et al, eds. The University of Texas Medical Branch Series in Biomedical Science, Austin, TX, University of Texas Press, p. 319-25, 1987.. Unique Identifier : AIDSLINE ICDB/89650501
Hooks JJ; Detrick B; Immunology and Virology Section, Lab. of Immunology, Natl. Eye; Inst., NIH, Bethesda, MD 20892
The process of interferon (IFN) production during the course of an immune response may be augmented or depressed in certain disease states, and it may then either modify certain responses or contribute to some of the clinical manifestations. Alterations in the IFN system can be evaluated by abnormally high IFN in the
The Interferon System. A Current Review to 1987. Baron S et al, eds. The University of Texas Medical Branch Series in Biomedical Science, Austin, TX, University of Texas Press, p. 423-9, 1987.. Unique Identifier : AIDSLINE ICDB/89650511
Borden E; Paulnock D; Spear G; Byrne G; Merritt J; Brown R; Dept. of Human Oncology, Univ. of Wisconsin, Madison, WI 53792
Interferons (IFNs)--prototypic biological response modifiers--are the first such modifiers prepared by recombinant DNA technology to impact on treatment of human disease. The authors focus on changes in levels of major histocompatibility (MHC) proteins, 2-5A synthetase, and indoleamine-2,3-dioxygenase, as induced in v
The Interferon System. A Current Review to 1987. Baron S et al, eds. The University of Texas Medical Branch Series in Biomedical Science, Austin, TX, University of Texas Press, p. 447-52, 1987.. Unique Identifier : AIDSLINE ICDB/89650513
Cesario T; Yousefi S; Carandang G; Tilles J; Dept. of Medicine, Univ. of California Irvine Medical Center, 101; City Drive South, Orange, CA 92668
As clinical applications of human interferon (HuIFN) in treatment of respiratory viruses, herpesviruses, and hepatitis viruses are reviewed in other sections of the book, the present chapter covers therapeutic trials in which the HuIFN was used in a variety of other diseases, either known or presumed to be caused by v
The Interferon System. A Current Review to 1987. Baron S et al, eds. The University of Texas Medical Branch Series in Biomedical Science, Austin, TX, University of Texas Press, p. 461-7, 1987.. Unique Identifier : AIDSLINE ICDB/89650514
Imanishi J; Kishida T; Dept. of Microbiology, Kyoto Prefectural Univ. of Medicine,; Kawaramachi-Hirokoji, Kamikyo-ku, Kyoto 602, Japan
Clinical trials with interferon (IFN) in Japan are characterized by many companies joining in the trials and the use of all types of IFN: natural and recombinant (r) human (H) IFN-alpha, -beta, and -gamma. Natural HuIFN-alpha and -beta are each administered mainly at doses of 3-10
The Interferon System. A Current Review to 1987. Baron S et al, eds. The University of Texas Medical Branch Series in Biomedical Science, Austin, TX, University of Texas Press, p. 477-85, 1987.. Unique Identifier : AIDSLINE ICDB/89650516
The tumors discussed in this paper, both benign and malignant, have all been consistently associated with the presence of a DNA virus; there has been no proof, however, that the virus is, in fact, the principal inducer of the malignant process in any of these tumors. Treatment of virus-associated tumors with interfero
AIDS: Etiology, Diagnosis, Treatment, and Prevention. Second Edition. DeVita VT Jr et al, eds. Philadelphia, Lippincott, p. 79-86, 1988.. Unique Identifier : AIDSLINE ICDB/89650901
Broder S; Clinical Oncology Program, Div. of Cancer Treatment, NCI,; Bethesda, MD
Possible therapeutic interventions can be based on the emerging knowledge of the life cycle of the human immunodeficiency virus that causes AIDS and its related disorders. The characteristics of HIV as a retrovirus (cell binding and entry, integration, latency and reactivation, and protein production and assembly) are
AIDS: Etiology, Diagnosis, Treatment, and Prevention. Second Edition. DeVita VT Jr et al, eds. Philadelphia, Lippincott, p. 277-93, 1988.. Unique Identifier : AIDSLINE ICDB/89650911
Yarchoan R; Broder S; Clinical Oncology Program, Div. of Cancer Treatment, NCI,; Bethesda, MD
In the short period of time since AIDS was recognized as a new clinical entity, the virus responsible for causing this disease (HIV) has been identified and several agents have been found to block the replication of the virus in vitro. One of these is AZT
AIDS: Etiology, Diagnosis, Treatment, and Prevention. Second Edition. DeVita VT Jr et al, eds. Philadelphia, Lippincott, p. 295-303, 1988.. Unique Identifier : AIDSLINE ICDB/89650912
Polsky B; Armstrong D; Cornell Univ. Medical Coll., New York, NY
Compounds other than nucleoside analogs have shown activity against HIV infection in vitro and have entered the early stages of clinical evaluation. Treatments other than zidovudine ( AZT ) for HIV infection are described according to their supposed sit
Myers WA; Columbia University Center for Psychoanalytic Training and; Research.
In this paper, the author has presented an in-depth case report of the ongoing analysis of an aging male homosexual, who entered analysis in his late fifties because of his fear of AIDS. This initial spur to his motivation to achieve characterological change was joined subsequently by two other factors. These were the
Aitken C; Rehabilitation Studies Unit, University of Edinburgh, Princess; Margaret Rose Hospital, UK.
It used to be fashionable to begin consideration of psychosomatics about philosophy of mind and body. Nowadays it is a topic about health and practical care of patients--principally about the psychological aspects of any illness. Pathogenesis is becoming understood with some risk factors clearly identifiable. The high
Senturia YD; Peckham CS; Institute of Child Health, London.
Cases of paediatric AIDS have increased each year in the USA, as the disease has spread to the heterosexual community. In the USA the geographic distribution of perinatal AIDS cases mirrors the distribution of cases in women. To date, 503 HIV antibody positive women have been reported in the UK. It is likely that the
Ann Pathol. 1988;8(4-5):281-9. Unique Identifier : AIDSLINE MED/89105199
Gray F; Fenelon G; Gherardi R; Favolini M; Goulon M; Guillard A; Poirier J; Departement de Pathologie Tissulaire et Cellulaire, Hopital; Henri Mondor, Creteil.
The central nervous system (CNS) of 40 patients who died of acquired immune deficiency syndrome (AIDS) between August 1982 and August 1987 was examined. In 15 cases, multinucleated giant cells (MGC) characteristic of Human Immunodeficiency Virus (HIV) infection were observed. In 3 cases ultrastructural examination dis
de Jong JC; Paccaud MF; de Ronde-Verloop FM; Huffels NH; Verwei C; Weijers TF; Bangma PJ; van Kregten E; Kerckhaert JA; Wicki F; et al; Rijksinstituut voor Volksgezondheid en Milieuhygiene, Laboratory; of Virology, Bilthoven, The Netherlands.
Swine influenza A (H1N1) viruses were isolated from two people in Switzerland and one in the Netherlands in early 1986. In haemagglutination-inhibition and neuraminidase-inhibition assays, the three viruses were closely related to one
Fox E; Constantine NT; Abbatte EA; Said-Salah; Rodier G; US Naval Medical Research Unit 3 (NAMRU-3), Cairo.
In order to determine whether HTLV-I (a recently discovered retrovirus causing T-cell leukaemias and lymphomas, as well as tropical spastic paraparesis) was present in Djibouti in 1988, we investigated 576 subjects belonging to various groups at risk of acquiring HIV, a related r
A total of 24 chronic carriers of HBsAg, HBeAg and hepatitis B virus (HBV)-DNA were included in a controlled trial. The patients were randomly assigned to four groups: Group I (n = 6): control; group II (n = 6): 2.5 MU; group III (n = 6): 5 MU and group IV (n = 6): 10 MU rIFN-alpha/m2 body surface 3 times weekly i.m.
Stamm B; Grant JW; Institute of Pathology, University Hospital, Zurich,; Switzerland.
Patients with human immunodeficiency virus (HIV)-associated disease are subject to a wide variety of unusual opportunistic infections and to the development of malignant tumours. These complications frequently manifest themselves within the gastrointestinal tract and endoscopic biopsies may contribute to their diagnos
The nation s response to AIDS has failed to effectively curb the spread of AIDS among intravenous (IV) drug users, who are primarily responsible for transmitting the disease to heterosexuals and children. A study assessing awareness of AIDS among 58 county jail inmates--27 IV drug abusers and 31 nonintravenous drug ab
Morgan MK; Clark ME; Hartman WL; Psychology Service, Veterans Administration Medical Center, Bay; Pines, Florida 33542.
Little is known psychometrically about the pattern of cognitive decline associated with acquired immunodeficiency syndrome (AIDS)-related dementia . Pre- and posttest results are presented to illustrate a case example of rapid cognitive decline. Increased psychometric assessment is
Bukasa KS; Sindic CJ; Bodeus M; Burtonboy G; Laterre C; Sonnet J; Department of Neurology, St-Luc Hospital, University of Louvain,; Brussels, Belgium.
CSF and serum samples from 16 AIDS patients were tested for the presence of anti-HIV antibodies either by classical serological methods or by an immunoblot technique based on agarose gel isoelectric focusing and transfer of the specific IgG antibodies onto HIV antigens-loaded nitrocellulose sheets. This method enabled
Kakigi R; Shibasaki H; Kuroda Y; Endo C; Oda K; Ikeda A; Hashimoto K; Department of Internal Medicine, Saga Medical School, Japan.
Multimodality evoked potentials (EPs) consisting of somatosensory EPs (SEPs), visual EPs (VEPs) and brainstem auditory EPs (BAEPs) were studied in 16 cases with HTLV-I associated myelopathy (HAM). Median nerve SEPs were normal in all cases. In posterior tibial nerve SEPs, the potential recorded at the 12th thoracic sp
Mann DL; Murray C; Yarchoan R; Blattner WA; Goedert JJ; Laboratory of Human Carcinogenesis, National Cancer Institute,; Bethesda, Maryland 20892.
HLA-A, -B, -C, -DR, and -DQ antigen phenotypes were determined in 266 Caucasian homosexual men, 90 of whom were HIV-1 seronegative, 94 HIV-1 seropositive AIDS-free, and 82 with a diagnosis of AIDS [36 with Kaposi s sarcoma (KS), 34 with opportunistic infection (OI), and 12 with KS and OI]. No significant differences i
Murphy EL Jr; De Ceulaer K; Williams W; Clark JW; Saxinger C; Gibbs WN; Blattner WA; Viral Epidemiology Section, National Cancer Institute, Bethesda,; MD 20892.
To determine whether systemic lupus erythematosus (SLE) is associated with human T-lymphotropic virus, type I (HTLV-I) infection in Jamaica , an endemic area for the virus, we studied 63 patients with SLE at the University Hospital of the West Indies in Kingston. Antibodies to HTLV
Levy RM; Janssen RS; Bush TJ; Rosenblum ML; Department of Neurological Surgery, School of Medicine,; University of California, San Francisco 94143.
Data from the Centers for Disease Control (CDC) and from the hospitals affiliated with the University of California, San Francisco show a significant incidence of neurological complications in AIDS patients and suggest that patients from different risk groups and geographic regions are at different relative risk for s
Fuchs D; Unterweger B; Hausen A; Reibnegger G; Werner ER; Hengster P; Hinterhuber H; Dierich MP; Wachter H; Blattner WA; et al; Institute of Medical Chemistry and Biochemistry, University of; Innsbruck, Austria.
Kaminski HJ; Katzman M; Wiest PM; Ellner JJ; Gifford DR; Rackley R; Iskandar SS; Lederman MM; Department of Medicine, Case Western Reserve University,; Cleveland, Ohio.
Three cases of congestive cardiomyopathy complicating the acquired immune deficiency syndrome (AIDS) are reported. In one case, acute cardiac decompensation resulted in prolonged but ultimately reversible cardiogenic shock. In the second case, clinical signs of cardiac disease were precipitated by acute renal failure
Hammond GW; Buchanan D; Malazdrewicz R; Conway B; Tate R; Sekla L; Fast M; Ronald AR; Cadham Provincial Laboratory, University of Manitoba, Winnipeg,; Canada.
Two hundred fifty individuals from high risk categories were enrolled in a seroprevalence survey for human immunodeficiency virus (HIV) infections in Winnipeg. The overall seroprevalence in the Manitoba AIDS Virus Epidemiology Study (MAVES) was 5.2%. Of 2651 diagnostic and screening specimens in the province of Manito
Murphy EL; Gibbs WN; Figueroa JP; Bain B; LaGrenade L; Cranston B; Blattner WA; Viral Epidemiology Section, National Cancer Institute, Bethesda,; MD 20892.
From August 1985 through January 1986, 125 homosexual or bisexual men from the Kingston area were enrolled in a study to evaluate risk factors for infection with human immunodeficiency virus (HIV) and human T-lymphotropic virus type I (HTLV-I). Twelve men (10%) were seropositive for HIV and 6 (5%) for HTLV-I; 1 man ha
Seidlin M; Krasinski K; Bebenroth D; Itri V; Paolino AM; Valentine F; Department of Medicine, New York University Medical Center, New; York.
In order to evaluate the frequency of sexual transmission of human immunodeficiency virus (HIV) among promiscuous heterosexuals, we studied the prevalence of HIV infection among a group of predominantly Caucasian call girls and women working for escort services and massage parlors in New York City. In the 78 subjects
Lovejoy NC; Moran TA; Paul S; Department of Physiological Nursing, San Francisco General; Hospital/University of California.
Patients with acquired immune deficiency syndrome (AIDS) or AIDS-related complex (ARC) are developing beliefs, behaviors, and a knowledge bases that may affect their health status, sense of well-being, and health care needs. However, little documentation of these changes exists. Consequently, the purpose of this study
Anderson RM; Group, Department of Pure and Applied Biology, Imperial College,; London University, England.
The role of mathematical models in the study of human immunodeficiency virus (HIV) transmission, the epidemiology and demographic impact of acquired immune deficiency syndrome (AIDS), and the course of infection within an individual is reviewed. Attention is focused on the part models can play in short-term prediction
Des Jarlais DC; Friedman SR; New York State Division of Substance Abuse Services, NY 10013.
Intravenous drug use continues as the second most common risk behavior associated with acquired immune deficiency syndrome (AIDS) in the United States and Europe. Recently there has been increased public and research attention to this problem. Five areas of public health concern for AI
Wofsy CB; Department of Medicine, University of California, San Francisco.
To meet the needs of human immunodeficiency virus (HIV) infected individuals, innovative approaches to health care delivery have been developed that could affect the entire worldwide medical care system. Innovations include dedicated inpatient and outpatient AIDS treatment and research units, extensive community servi
Kirby M; Court of Appeal, Supreme Court of New South Wales, Sydney,; Australia.
Public alarm about the spread of AIDS leads to public demand for drastic laws to contain the epidemic and to punish those who spread it. In this paper, attention is drawn to the limitations of the law in achieving the modification of human behavior. Successes and failures in public health education campaigns, directed
Launay JM; Copel L; Callebert J; Corvaia N; Lepage E; Bricaire F; Saal F; Peries J; F.R.A. Claude Bernard Neurochimie des Communications Cellulaires,; Hopital Claude, Bernard, Paris, France.
Significantly (p less than 0.001) decreased whole blood unconjugated serotonin levels were detected in AIDS patients as compared to patients with advanced cancers and to healthy individuals.
Ryder MI; Winkler JR; Weinreb RN; Department of Stomotatology, University of California, San; Francisco 94143-0650.
Alterations in polymorphonuclear leucocyte (PMN) function are frequently associated with intraoral disease. The purpose of this study was to evaluate if alterations exist in three early stimulatory events of PMN function in individuals with intraoral manifestations of human immunodeficiency virus (HIV) infection. Peri
Yeh CK; Fox PC; Ship JA; Busch KA; Bermudez DK; Wilder AM; Katz RW; Wolff A; Tylenda CA; Atkinson JC; et al; Clinical Investigations and Patient Care Branch, NIDR, Bethesda,; MD 20892.
We have examined the hypothesis that individuals infected with human immune deficiency virus type 1 (HIV-1) experience significant, specific alterations in mechanisms protecting the oral cavity prior to the appearance of AIDS-related systemic opportunistic infections. In a study of 13 early-stage, stable anti-HIV anti
MacDonell KB; Chmiel JS; Goldsmith J; Wallemark CB; Steinberg J; Byers E; Phair JP; Department of Medicine, Northwestern University Medical School,; Chicago, IL 60611.
We evaluated the usefulness of both the Walter Reed (WR) staging classification and the component criteria used in the system in predicting progression to AIDS. The WR classification was applied to a cohort of 431 men who were seropositive for the human immunodeficiency virus on entry into a prospective study. The WR
Bulkin W; Brown L; Fraioli D; Giannattasio E; McGuire G; Tyler P; Friedland G; Ritter Scheuer Hospice, Beth Abraham Hospital, Bronx, NY 10467.
We report on the initial experience in hospice care for a predominantly poor, black and Hispanic intravenous drug user AIDS population in New York City. Hospice care was provided in a skilled nursing facility with a certified hospice program delivering home care and inpatient care. A formal education program preceded
Belongia EA; Golubjatnikov R; McClellan-Tilson B; Wiesen RL; Vergeront JM; Davis JP; Section of Acute and Communicable Disease Epidemiology, Wisconsin; Division of Health, Madison 53701.
We assessed human immunodeficiency virus (HIV) antibody prevalence and drug-using behaviors among intravenous drug abusers (IVDAs) enrolled in Milwaukee drug treatment programs. Six (2.3%) of 266 study participants were positive for HIV antibody by Western blot assay. A history of needlesharing was reported by 91% of
Papaevangelou G; Roumeliotou A; Kallinikos G; Papoutsakis G; Trichopoulou E; Stefanou T; WHO Collaborating AIDS Reference Centre, Athens School of; Hygiene, Greece.
From March 1984 to November 1985, 350 Greek registered prostitutes were screened for anti-HIV. Twelve of them (3.4%) were found to be positive. To monitor and control the further spread of HIV infection, an intensive educational campaign was established and screening every 3 months was implemented. Until October 1986,
Titti F; Rezza G; Verani P; Butto S; Sernicola L; Rapicetta M; Sarrecchia B; Oliva C; Rossi GB; Laboratory of Virology, Istituto Superiore di Sanita, Rome,; Italy.
A seroepidemiological survey of a group of 291 intravenous drug abusers (IVDAs), 45 household contacts of IVDAs, and 39 laboratory workers has been carried out to determine the prevalence of HIV-1, HIV-2, HTLV-1, and HBV antibodies in the sera, as well as to evaluate the role of various risk factors. Among i.v. drug a
Kosten TR; Kleber HD; Yale University School of Medicine, Department of Psychiatry, New; Haven, CT.
The differential diagnosis of psychiatric comorbidity in substance abusers is important in order to provide effective pharmacological and psychotherapeutic treatments for the comorbid psychiatric disorders. Differential diagnosis of an underlying psychiatric disorder depends on the type of drug abused and the phase of
Greif GL; Price C; University of Maryland at Baltimore, School of Social Work and; Community Planning 21201.
The I.V. drug abuser who has a history of non-compliance is perhaps the most difficult to reach among those at risk for contracting AIDS. This article details one approach being attempted at HERO, that of a community-based support group run by an indeginous worker where the emphasis is on support, education, and outre
Bergstrom E; School Health Service, Community of Umea, Sweden.
Health education in schools is a subject that many people talk about but few do something about. One reason for this is that it is an interdisciplinary subject. This paper describes a community model with a ten-point program. Local health teams with collaboration between the school health service and the teachers are
Dorfman RF; Berry GJ; Department of Pathology, Stanford University Medical Center, CA; 94305.
Kikuchi s necrotizing lymphadenitis has now become recognized in many parts of the world as a well-defined clinicopathologic entity with a remarkable predilection for cervical lymph nodes of young women. The morphologic features encountered in lymph nodes are distinctive and should enable pathologists to establish the
Circulating immune complexes and platelet associated immunoglobulins G (PAIgG) were measured in 14 clinically asymptomatic and 9 diseased HIV infected subjects and compared to their platelet counts in the peripheral blood. In both groups, circulating immune complexes were found to be increased even in the presence of
Garrido G; Gomez-Reino JJ; Fernandez-Dapica P; Palenque E; Prieto S; Rheumatology Unit, Hospital Primero de Octubre, Madrid, Spain.
There is a clear difference between TB infection and TB. Transition from the former to the latter involves host factors and perhaps environmental elements. Currently, more individuals with immunosuppressive situations caused by aging, debilitating diseases, immunosuppressive therapies, and HIV-III infection are predis
The questioning of the population of Moscow, carried out over the telephone, revealed that the information campaign conducted in 1987 was partially effective.
Lindblom B; Wetterling G; Link H; State Institute for Blood Group Serology, Linkoping University; Hospital, Sweden.
Genetic subtypes of group-specific component (Gc), a protein possibly influencing susceptibility to human immunodeficiency virus infection, were assessed by isoelectric focusing of plasma from 88 patients with multiple sclerosis (MS) and related to frequencies among 3394 control individuals subjected to paternity stud
Miyayama H; Takeya M; Takahashi K; Koito A; Hattori T; Takatsuki K; Second Department of Pathology, Kumamoto University Medical; School, Japan.
An autopsy case of a 37-year-old Japanese man, confirmed as an AIDS patient infected by an undetermined route of transmission, is presented. The initial symptoms of full-blown AIDS in this case were neurological, and the patient died of severe pneumonia 9 months after onset. The main histo- and immunopathological feat
Am J Dermatopathol. 1988 Dec;10(6):487-96. Unique Identifier : AIDSLINE MED/89116455
Manabe T; Hirokawa M; Sugihara K; Sugihara T; Kohda M; Department of Pathology, Kawasaki Medical School, Kurashiki,; Japan.
This report describes the clinical and pathological features of cutaneous lesions observed in a 73-year-old woman with terminal adult T-cell leukemia/lymphoma (ATLL) and a 42-year-old man who had chronic ATLL with persistent nasal stuffiness and rhinorrhea of 2 years duration. Histology of the skin lesions from these
Proc Annu Conf Res Med Educ. 1988;27:216-20. Unique Identifier : AIDSLINE MED/89116866
Vincent DS; Cooper GS; Harvey J; Noel GL; Department of Medicine, Walter Reed Army Medical Center,; Washington, DC 20307.
A simple intervention to teach second year medical students how to interview HIV patients was assessed using an Objective Structured Clinical Examination. The results showed that students omitted a broad range of content issues relating to the social support system of healthy HIV patients.
Proc Annu Conf Res Med Educ. 1988;27:221-5. Unique Identifier : AIDSLINE MED/89116867
Barkley SE; Mason JL; Kappelman MM; Office of Medical Education, University of Maryland, School of; Medicine, Baltimore 21201.
The purpose of this survey was to determine entering freshman medical student awareness of and attitudes toward AIDS. It is encouraging to find that, in general, students are well informed about AIDS before entering medical school; they have very real concerns about the possibility of contracting AIDS themselves as fu
AIDS Res Hum Retroviruses. 1988 Dec;4(6):399-407. Unique Identifier : AIDSLINE MED/89118009
Brown AL; Monaghan P; Department of Genetics, University of Edinburgh, UK.
We have estimated the frequency of synonymous (KS) and amino acid replacement nucleotide substitutions (KA) among gag and env genes of published HIV sequences. The ratio of KS to KA can be used as an indicator of the intensity of the selective constraints on the amino acid sequence of a protein. By this approach we ha
Nucleoside analogs were synthesized and tested for anti-HIV-1 activity in two in vitro test systems using MT-4 cells and peripheral blood lymphocytes. Cytotoxicity was assessed in both assays and additionally in several human lymphoblastoid cell lines. One analog, 3 -fluoro-3 -deoxythymidine, exhibited higher antivira
AIDS Res Hum Retroviruses. 1988 Dec;4(6):475-85. Unique Identifier : AIDSLINE MED/89118017
Dalgleish A; Richardson J; Matutes E; Cruickshank K; Newell A; Sinclair A; Thorpe R; Brasher M; Weber J; Catovsky D; et al; MRC Clinical Research Centre, Harrow.
All 17 patients with tropical spastic paraparesis (TSP) in a series seen in the United Kingdom have antibodies to the human T cell leukemia virus type 1 (HTLV-1). Cultured peripheral blood lymphocytes from these patients formed multinucleated giant cells and reacted with sera and monoc
AIDS Res Hum Retroviruses. 1988 Dec;4(6):493-9. Unique Identifier : AIDSLINE MED/89118019
Golenbock DT; Guerra J; Pfister J; Golubjatnikov R; Tejada A; Abugattas J; Kemper R; Maki DG; Department of Medicine, University of Wisconsin School of; Medicine, Madison.
We serologically tested 140 female prostitutes (mean age, 30 years) from the port city of Callao, Peru , for evidence of infection with human immunodeficiency virus (HIV), Chlamydia trachomatis, Treponema pallidum, herpes simplex vir
Dodds RD; Guy PJ; Peacock AM; Duffy SR; Barker SG; Thomas MH; Department of Surgery, St. Peter's Hospital, Chertsey, Surrey.
In a study to investigate the incidence and significance of surgical glove perforation, bacterial contamination of surgeons hands and gloves before and after operation was measured and the gloves tested for damage. Perforations were found in 74 of 582 gloves (12.7 per cent) and occurred in 34.5 per cent of operations
Sirianni MC; De Sanctis G; Macchi B; Soddu S; Ensoli F; Aiuti F; Fontana L; Department of Allergy and Clinical Immunology, University of; Rome, La Sapienza, Italy.
An H9-HTLV-III-infected cell line was used as a target in a short-term (3-hr) Cr release assay to assess its sensitivity to lysis by peripheral blood lymphocytes (PBL) from normal donors. The single cell cytotoxicity assay (SCCA) on poly-L-lysine-coated coverslips was used to investigate further the mechanism of bindi
Antonaci S; Jirillo E; Stasi D; De Mitrio V; La Via MF; Bonomo L; Medicina Clinica, University of Bari Medical School, Bari, Italy.
Several deficits of immune response have been reported in hemophiliacs. In order to evaluate the overall immune function in this disease, we have investigated peripheral blood mononuclear cells (PBMC) surface phenotype, lymphokine production, B cell responsiveness, monocyte- and polymorphonuclear (PMN) cell-mediated r
Krowka JF; Stites DP; Moss AR; Casavant CH; Carlson JR; Chermann JC; Barre-Sinoussi F; Rodgers RP; Bacchetti P; McHugh TM; et al; Department of Laboratory Medicine, University of California, San; Francisco 94143.
Serum and leukocytes from a cohort of homosexual males were analyzed to determine the interrelationships of antibodies to human immunodeficiency virus (HIV), serum HIV antigen levels, and phenotypical differences in lymphocyte subpopulations of HIV antibody-positive (HIV Ab+) and HIV antibody-negative (HIV Ab-) homose
Artelt P; Morelle C; Ausmeier M; Fitzek M; Hauser H; Cell Biology and Genetics Section, GBF-Gesellschaft fur; Biotechnologische Forschung mbH., Braunschweig, (F.R.G.).
We have constructed two related types of multi-cloning mammalian expression vectors. The first, pMPSVEH/HE, carries the promoter of the myeloproliferative sarcoma virus (MPSV). This promoter was found to be stronger than both the SV40 early and the trans-activated human immunodeficiency virus promoters in many cell li
Colebunders R; Lusakumuni K; Nelson AM; Gigase P; Lebughe I; van Marck E; Kapita B; Francis H; Salaun JJ; Quinn TC; et al; Projet SIDA, Department of Public Health, Kinshasa, Zaire.
To determine the aetiology of persistent diarrhoea in African patients with acquired immunodeficiency syndrome (AIDS), 42 patients with human immunodeficiency virus (HIV) and persistent diarrhoea were enrolled in a microbiological, endoscopic, and histological study. Cryptosporidium was the intestinal parasite most of
Three cases of acquired immune deficiency with unusual dermatological symptoms of early syphilis are reported. All three patients were promiscuous homosexual men with confirmed HIV infections and signs of an impaired immune status. One patient was apparently healthy, one had the AIDS-related complex and one was suspec
The case is reported of a 31-year-old homosexual male who developed distinct maculopapular and papulovesicular exanthema with aphthous-like, painful lesions of the oral mucosa, together with marked general symptoms (fever, diarrhoea, lymphadenopathy). This clinical picture suggested the primary acute phase of an initi
Lee RE; University of Pittsburgh School of Medicine, Pennsylvania.
The disease most likely to be associated with large numbers of bone marrow storage histiocytes is Gaucher s disease. In our community of western Pennsylvania, eastern Ohio, and West Virginia, we have encountered 30 patients with Gaucher s disease during the past 25 years. During the same 25 years, a group of about 20
Wuest D; Goldfinger D; Taft B. Schreiber Blood Bank, Cedars-Sinai Medical Center, Los; Angeles, CA 90048.
Neurologic complications, including both the acute and chronic forms of inflammatory demyelinating polyradiculoneuropathy (IDP) are becoming more prevalent among patients with the acquired immunodeficiency syndrome (AIDS) and AIDS-related-complex (ARC). Although the etiology of the above radiculoneuropathies is not kn
Mathiesen T; Sundqvist VA; Albert J; Ohlsson E; Wahren B; Department of Virology, National Bacteriological Laboratory,; Stockholm, Sweden.
Sera from 32 HIV-infected patients and 20 controls were assayed for HIV antigen (HIV-Ag) and antibodies following acid hydrolysis. Acid hydrolysis, followed by neutralization immediately prior to the assay, was found to be a simple means to solubilize immune complexes and allowed recovery of 40-50% of complexed antige
Koopman J; Simon C; Jacquez J; Joseph J; Sattenspiel L; Park T; Department of Epidemiology, University of Michigan, Ann Arbor.
Deterministic simulation models are used to show that HIV transmission dynamics in homosexual populations can be strongly affected by sexual partner selectiveness. The type of selectiveness or biased mixing examined is where individuals with similar new partnership formation rates are more likely to form a pair than w
Tsoukas CM; Hadjis T; Shuster J; Theberge L; Feorino P; O'Shaughnessy M; Division of Clinical Immunology, Montreal General Hospital,; Canada.
To examine the relative risk of transmission of the human immuno-deficiency virus (HIV) through bites and scratches, we studied 198 health care workers, 30 of whom were traumatized in this fashion while caring for an aggressive AIDS patient. This violent patient frequently bit or scratched others, his mouth had blood
Reid MJ; Goetz DW; Zajac RA; Houk RW; Boswell RN; Department of Medicine, Wilford Hall USAF Medical Center,; Lackland AFB, San Antonio, TX 78236.
We prospectively studied 157 HIV antibody-positive U.S. Air Force personnel identified by universal ELISA screening and confirmed by Western blot. They were initially evaluated and then re-evaluated at least once at approximately 1 year intervals. In order to determine which if any demographic and serologic cofactors
Med Trop (Mars). 1988 Oct-Dec;48(4):327-35. Unique Identifier : AIDSLINE MED/89126887
Coulaud JP; Institut de Medecine et d'Epidemiologie Tropicales, Hopital; Claude Bernard, Paris.
The AIDS case definition of Bangui WHO workshop is more convenient for Africa and increases the number of cases reported to WHO. Natural history of HIV infection is the same in Africa as in the developed countries of western world. The clinical pattern of African Aids is mainly the result of opportunistic infections a
Med Trop (Mars). 1988 Oct-Dec;48(4):337-44. Unique Identifier : AIDSLINE MED/89126888
Barabe P; Digoutte JP; Tristan JF; Peghini M; Griffet P; Jean P; Seignot P; Sarthou JL; Leguenno B; Berlioz C; et al; Medecin Chef des Services Medicaux, Hopital Principal de; Dakar.
The authors report on the results of an investigation carried out on 109 HIV seropositives ascertained by the Dakar Central Hospital between February 20, 1987 and May 31, 1988. These seropositives affected 44 patients with AIDS (0.78% of admitted patients) and 65 seropositive people of which 43 blood donors (1.35% of
Med Trop (Mars). 1988 Oct-Dec;48(4):345-9. Unique Identifier : AIDSLINE MED/89126889
Pichard E; Guindo A; Grossetete G; Fofana Y; Maiga YI; Koumare B; Traore S; Maiga M; Brun-Vezinet F; Rosenheim M; Medecine Interne C.D. Hopital National du Point G, Bamako,; Mali.
This review summarises epidemiological and clinical data of HIV infection who was recognized in Mali since 1985. The most important rate of seropositivity for HIV is observed in the prostitutes group (40%). The estimated seroprevalence for adult population is between 1% and 5%. 46 ca
Med Trop (Mars). 1988 Oct-Dec;48(4):351-7. Unique Identifier : AIDSLINE MED/89126890
Lesbordes JL; Medecin des Hopitaux des Armees, Service de Medecine Interne; et Cardiologie, Centre Hospitalier des Armees Hippolyte Larrey,; Toulouse, France.
In Bangui ( Central African Republic ), where seroprevalence of HIV is 11% in the adult population, AIDS presents some clinical aspects different from the ones known in the west; the clinical experience reported in this paper is based on 504 cases infested by HIV grou
Med Trop (Mars). 1988 Oct-Dec;48(4):359-66. Unique Identifier : AIDSLINE MED/89126891
Laroche R; Floch JJ; Ndabaneze; Kadende P; Kamanfu G; Service de Sante des Armees, Centre Hospitalier de Kamenge,; Bujumbura, Burundi.
The authors describe their experience of the infection by the virus of the human immunodeficiency HIV-1 in Burundi . The acquired immunodeficiency syndrome was brought to light in 1983 by the emergence of cryptococcal meningitis, Kaposi s sarcomas, disseminated candidiasis. 109 cas
Med Trop (Mars). 1988 Oct-Dec;48(4):367-72. Unique Identifier : AIDSLINE MED/89126892
Beuzit Y; Mayoulou-Niamba JB; Loemba H; Makuwa M; Service de Medecine, Hopital Central des Armees Pierre; Mobengo, Brazzaville, R.P.C.
During a period of 20 months, 204 cases of AIDS were diagnosed among adults in the Medicine Department of the Pierre Mobengo Armed Forces Central Hospital, Brazzaville. The authors review the clinical and evolutive aspects in admitted patients during these period of time, taking into consideration the problems of diag
Med Trop (Mars). 1988 Oct-Dec;48(4):373-4. Unique Identifier : AIDSLINE MED/89126893
Klotz F; Boguikouma JB; Delaporte E; Peteers M; Ndong JB; Delmarre B; Nguemby Mbina C; Medecin des Hopitaux des Armees, Centre; Hospitalo-Universitaire de Libreville.
In 1986 prevalence rates of anti-HIV1 antibodies in randomly selected asymptomatic gabonese population ranged from 0.2% in rural areas to, 1.8% in Libreville (the largest town). We report the first description of AIDS cases observed in the hospitals of Libreville and Franceville between 1985 and 1987. 23 patients (14
Med Trop (Mars). 1988 Oct-Dec;48(4):381-9. Unique Identifier : AIDSLINE MED/89126895
Merlin M; Josse R; Trebucq A; Mouanda V; Kouka-Bemba D; Service de sante des Armees, OCEAC, Younde.
Since 1985, OCEAC, the organization for control of widespread endemic disease in Central Africa, has managed an epidemiological surveillance programme concerning HIV infection and AIDS in six countries of the Sub-Region: Cameroon , Tchad,
In this work are summarized the results of the serological investigations about HIV1 and HIV2 done since 1986 in the Republic of Cameroon , using the Henderson s cluster sampling method (2). With regard to neighbour countries results, the prevalence of specific antibodies against
Since late 1985, the Institut Pasteur de Madagascar has studied the problem of the distribution of HIV in the island. With the approval and cooperation of the Malagasy Ministry of Health, a number of different surveys have been undertaken, particularly of those sections of the
Med Trop (Mars). 1988 Oct-Dec;48(4):401-7. Unique Identifier : AIDSLINE MED/89126898
Cathebras P; Vohito JA; Yete ML; Lagarde R; Vohito MD; Ramiara JP; Mbolidi CD; Nama J; Ngbali J; Siopathis MR; et al; Hopitaux (Medecine Interne). Centre de Formation et de; Recherches en Medecine et Sante Tropicales, Hopital; Houphouet-Boigny, Marseille.
In order to determine the proportion of tuberculosis (TB) patients in Bangui ( Central African Republic ) infected with human immunodeficiency virus (HIV), we collected prospectively serum samples from all new TB patients seen at the University Hospital in Bangui duri
Med Trop (Mars). 1988 Oct-Dec;48(4):409-11. Unique Identifier : AIDSLINE MED/89126899
Lesbordes JL; Coulaud X; Medecin des Hopitaux des Armees, Toulouse, France.
In Bangui ( Central African Republic ) where HIV1 prevalence was 7.8% in 1987, 61 cases of herpes zoster have been studied: 17 during AIDS and 44 isolated cases. During AIDS, herpes zoster has no prognosis value. When it seems to be isolated, herpes zoster is closely
Med Trop (Mars). 1988 Oct-Dec;48(4):417-23. Unique Identifier : AIDSLINE MED/89126901
Zagury D; Salaun JJ; Bernard J; Dechazal L; Goussard B; Lurhuma Z; l'Institut P. et M. Curie, Universite de Jussieu, Paris, France.
The first experimental immunization of human against the AIDS retrovirus HIV-1 was started in a series of HIV seronegative healthy volunteers in november 1986. Priming used a vaccinia virus recombinant (V25) expressing Gp 160 env determinants of HTLV III B at the surface of infected cells. This priming which induced a
Ross MW; AIDS Programme, South Australian Health Commission, Adelaide.
Psychological reactions to sexually transmissible disease (STD) infection are common, occurring in up to 85% of some patients with STDs: Hart has suggested that they are among the most common conditions encountered in venereology. Previous psychiatric disturbances in STD patients, however, are relatively uncommon and
Westblom TU; Belshe RB; Marshall University School of Medicine, Department of Medicine,; Huntington, West Virginia 25755-9410.
A 47-year-old patient with AIDS and cerebral toxoplasmosis was treated with sulfadiazine pyrimethamine for 5 days. After developing a severe rash his regimen was changed to clindamycin 600 mg q 6 h intravenously and pyrimethamine 25 mg daily, given for 37 days. This resulted in improvement of clinical symptoms and com
At autopsies of 20 patients with AIDS, 7 cases with gastrointestinal involvement by Kaposi s sarcoma were observed. The lesions were found in nearly all parts of the digestive canal; although we observed a certain accumulation in the upper gastrointestinal tract. Macroscopically the spectrum of appearances extended fr
Z Gastroenterol. 1988 Jul;26(7):380-7. Unique Identifier : AIDSLINE MED/89131116
Hess G; Weber C; Rossol S; Voth R; Drees N; Meyer zum Buschenfelde KH; I. Medizinische Klinik, Johannes-Gutenberg-Universitat Mainz.
The HBsAg carrier state may present as chronic active hepatitis which may proceed to cirrhosis of the liver and to primary liver cell carcinoma. The large scale production of interferons made these substances available for long-term treatment. A deficiency in interferon production in chronic type B hepatitis presented
Michaud PA; Stutz T; Samuel M; Service de la sante publique et de la planification sanitaire,; Lausanne.
In the first section of the article, the authors consider the epidemiological data available in Switzerland mid-june 1988, concerning persons between 15 to 24, either already suffering from AIDS or HIV-positive. These data are compared with those from Europe and the
The incidence of AIDS cases in intravenous drug abusers is growing faster than in other risk groups, in Switzerland as well as in Europe in general. By end of May 1988, 27% of all AIDS cases registered nationally were injecting drugs. The prevalence of HIV antibodies is known
Samuel MC; Engel RR; Swiss Federal Office of Public Health, Bern.
This report is a brief summary of important points concerning AIDS and homosexual men. We present the current overall figures of the cumulative AIDS incidence for Switzerland , the United States and the world and similar figures for homosexual m
Routes of transmission of HIV which play an important role in the population are known. Sexual transmission, infection through needle sharing by i.v. drug addicts, accidental blood contacts and transmission from the infected pregnant mother to her child are seen. The number of new infections depends on the number of a
Bondolfi A; Institut fur Sozialethik der Universitat Zurich.
Ethical implications are inherent to any information policy in conjunction with AIDS. It is difficult, in this context, to differentiate clearly between bio-medical recommendations and suggestions directly oriented to sexual behaviour. In the strict context of prevention policy, the author attempts to demonstrate how
Lehmann P; Hausser D; Dubois-Arber F; Gutzwiller F; Institut universitaire de medecine sociale et preventive,; Lausanne.
Since 1985 the Swiss Federal Office of Public Health and the Swiss AIDS Foundation are promoting AIDS prevention campaigns. A multimedia information campaign with the main slogan STOP-AIDS began in Feb. 1987 and is still under way. Multiplying effects are stimulated. An evaluation program is following continuously the
170 trade school students (main inquiry 142) between 18 and 21 in eight cantons were questioned via group discussions and questionnaire on their attitude to the STOP AIDS campaign, to the messages put across by the campaign and to the use of condoms. About half the trade school students recognise the personal appeal.
232 sera and 40 cerebrospinal fluid samples of altogether 125 patients in stages III or IV of a HIV-infection were tested for circulating antigen of Toxoplasma gondii by means of a three-layer enzyme-linked immunosorbent assay. Circulating antigen was detected in 32 sera of 20 patients (= 16% of all persons investigat
Ann Med Interne (Paris). 1988;139(6):403-4. Unique Identifier : AIDSLINE MED/89133289
Grateau G; Soffer M; Fritz P; Bonnin A; Sereni D; Cremer GA; Departement de Medecine Interne, Hopital Cochin, Paris.
Fever of undetermined origin in a young white heroin addict with a positive HIV (human immunodeficiency virus), serology was secondary to a staphylococcal perinephric abscess. Ultrasound examination and tomodensitometry allowed the diagnostic. Percutaneous drainage led to complete recovery. Interventional radiology as
Arch Sex Behav. 1988 Dec;17(6):481-97. Unique Identifier : AIDSLINE MED/89133785
Siegel K; Bauman LJ; Christ GH; Krown S; Memorial Sloan-Kettering Cancer Center, New York, New York.
In the absence of a vaccine or effective treatment for AIDS, health education remains the most effective strategy for stemming the spread of the epidemic. Among homosexual and bisexual men, who continue to account for the majority of AIDS cases, sexual practices have been identified as the principal risk factor. Conse
Kaplan LD; Hopewell PC; Jaffe H; Goodman PC; Bottles K; Volberding PA; Medical Service, San Francisco General Hospital Medical Center,; California.
To determine the distinguishing features of pulmonary Kaposi s sarcoma (KS) in patients with the acquired immunodeficiency syndrome (AIDS), we compared three groups of patients, 16 with endobronchial KS, 15 with endobronchial KS and an opportunistic lung infection, and 40 with Pneumocystis carinii pneumonia (PCP) with
Yuille MA; Hugunin M; John P; Peer L; Sacks LV; Poiesz BJ; Tomar RH; Silverstone AE; Department of Microbiology and Immunology, State University of; New York Health Science Center, Syracuse 13210.
In order to improve understanding of how HIV-1 infection down-modulates cell surface membrane expression of CD4, we have measured several parameters of CD4 expression in the human tumor T-cell lines CEM and MOLT-4 at different times after infection. Three independent HIV-1 isolates were used including one that encodes
Ada GL; Department of Immunology and Infectious Diseases, Johns Hopkins; School of Hygiene and Public Health, Baltimore, MD 21205.
This article initially discusses the types of responses elicited by infectious agents, such as viruses and the role of each response in preventing, limiting, and clearing the infection. An important response is the generation of immunological memory, in both the B and T cell compartments. Generally, attenuated viral v
Terwilliger E; Proulx J; Sodroski J; Haseltine WA; Laboratory of Biochemical Pharmacology, Dana-Farber Cancer; Institute, Boston, Massachusetts.
The products of the env gene of HIV-1 play critical roles in determining the host range of the virus and it cytopathicity, as well as forming an important focus of an infected individual s immune response to the virus. We describe the isolation and characterization of separate HeLa cell lines expressing the env gene p
Lauritzen E; Pluskal M; AIDS Laboratory, Statens Seruminstitut, Copenhagen, Denmark.
Immobilon-P Transfer Membrane (IM), a hydrophobic membrane, has been tested as a substrate for immunoblotting (Western blotting) in a routine serological assay for human immunodeficiency virus (HIV). Comparison of IM to nitrocellulose (NC) has shown the following advantages: (a) better retention of total HIV antigens,
Walmsley S; Salit IE; Brunton J; Department of Medicine, Toronto General Hospital, Ontario,; Canada.
Twenty-one episodes of Pneumocystis carinii pneumonia (PCP) and the acquired immune deficiency syndrome (AIDS) were treated with corticosteroids in the form of intravenous methylprednisolone or oral prednisone. A standard dose of 80 mg/day x 5 days was given for 15 episodes, whereas 6 patients received variable doses
Ann Ophthalmol. 1988 Dec;20(12):480-2. Unique Identifier : AIDSLINE MED/89116787
Seiff SR; Margolis T; Graham SH; O'Donnell JJ; Department of Ophthalmology, San Francisco General Hospital,; California.
Patients who are homosexual, intravenous drug abusers, or have received multiple blood transfusions are at greater risk to contract the immunosuppressive disorders of acquired immunodeficiency syndrome (AIDS) and AIDS-related complex (ARC). These persons also have a greater chance of developing serious neurologic comp
AIDS Res Hum Retroviruses. 1988 Dec;4(6):487-92. Unique Identifier : AIDSLINE MED/89118018
Zweig M; Bladen SV; Dubois GC; Samuel KP; Showalter SD; Papas TS; Program Resources, Inc., National Cancer Institute-Frederick; Cancer Research Facility, MD.
We have compared the antigenic qualities of human immunodeficiency virus type 1 (HIV-1) gp41 glycoprotein with a synthetic oligopeptide (peptide R21S) and a bacterially synthesized protein (protein 566), which are homologous with the N-terminal region of gp41, in enzyme-linked immunosorbent assays (ELISA) for detectin
An accurate, fast and simple method is presented for synthesis of a gene, or any DNA fragment with a defined sequence. The method is based on the observation that large (approx. 100 bp long) inserts can be cloned into a plasmid using a technique of oligodeoxynucleotide (oligo)-directed double-strand (ds) break repair.
Matutes E; Brito-Babapulle V; Worner I; Sainati L; Foroni L; Catovsky D; MRC Leukaemia Unit, Royal Postgraduate Medical School, London,; UK.
Mature (post-thymic) T-cell malignancies comprise a heterogeneous group of diseases with distinct clinical, morphological and immunophenotypic features. As some of these features overlap in the various disorders, it is essential to use a number of diagnostic criteria to define the clinicopathological entities, namely:
Bygbjerg IC; Lund JT; Hording M; Department of Infectious Diseases, Rigshospitalet, Copenhagen,; Denmark.
12 AIDS/ARC patients with or suspected of Pneumocystis carinii pneumonia were treated with co-trimoxazole and received supplementary folic or folinic acid to avoid peripheral blood cytopenia. Most patients developed decreased numbers of neutrophils and hemoglobin while receiving co-trimoxazole. Supplementary folate/fo
Provinciali L; Laurenzi MA; Vesprini L; Giovagnoli AR; Bartocci C; Montroni M; Bagnarelli P; Clementi M; Varaldo PE; Institute of Microbiology, University of Ancona, Italy.
Serum and CSF from 32 patients with idiopathic ALS, 30 age-matched controls and 30 MS patients were investigated regarding immunoglobulin concentration and virus-specific antibodies, the lymphocytes in the peripheral blood and lymphocyte subsets were also investigated. ALS patients results were compared with findings
Hyder JW; MacKeigan JM; Ferguson Clinic, Grand Rapids, Michigan 49503.
The immunocompromised host is becoming increasingly ubiquitous in the authors patient population. There are growing numbers of long-term transplant recipients, and combination chemotherapy is producing many long-term survivors. Of greatest concern is that the number of patients with human immunodeficiency virus (HIV)
Gene. 1988 Oct 30;70(2):415-7. Unique Identifier : AIDSLINE MED/89108027
Bukrinsky MI; Barsov EV; Shilov AA; D.I. Ivanovski Institute of Virology, Academy of Medical Sciences; of the USSR, Moscow.
A new expression vector (pBB1) has been constructed for the regulated expression of genes in Escherichia coli. Based on the pUC plasmids, the pBB1 carries lacIts allele of the lac repressor gene. This makes it possible to control expression of cloned genes by shifting the temperature from 30 degrees C to 42 degrees C.
Copeland TD; Oroszlan S; Laboratory of Molecular Virology and Carcinogenesis,; NCI-Frederick Cancer Research Facility, MD 21701.
The genetic locus and primary structure of the human immunodeficiency virus (HIV) protease was determined by comparing the data of protein analyses with the published data of the gene analysis. The complete sequence of HIV-1 and HIV-2 protease was synthesized by solid-phase peptide synthesis. The synthetic protease wa
Selected findings from the Multicenter AIDS Cohort Study (MACS) of homosexual/bisexual men are reviewed. High risk sexual behaviors, the use of drugs/alcohol, condom use, and behavior change are addressed in a public health context. The potential significance of education/behavior modification programs as strategies f
Levy RM; Bredesen DE; Department of Neurological Surgery, School of Medicine University; of California, San Francisco 94143.
Nearly 40% of AIDS patients develop neurological complications during the course of their illness, and about 10% experience neurological symptoms as the initial manifestations of AIDS. The most common neurological complication (14% of AIDS patients) is human immunodeficiency virus (HIV) encephalopathy, but opportunist
Haseltine WA; Dana-Farber Cancer Institute, Boston, MA 02115.
Some of the major features of the acquired immune deficiency syndrome may be understood in terms of the characteristics of the virus. Life-long infection is a consequence of the life cycle of retroviruses, the formation of stably integrated viral genetic information into host-cell DNA. The silent infection, controlled
Oberg B; Department of Virology, Karolinska Institute, Stockholm, Sweden.
The complicated machinery used by HIV for multiplication offers several targets for therapy and the viral enzymes appear to be particularly appropriate targets. For the HIV reverse transcriptase, this has been demonstrated by the clinical effect of zidovudine, but less toxic drugs are needed. The HIV protease is anoth
Ishizaki J; Okayama A; Tachibana N; Yokota T; Shishime E; Tsuda K; Mueller N; Second Department of Medicine, Miyazaki Medical School, Japan.
Higher positivity rates for prevalence of anti-HTLV-I antibody have been reported for the gelatin particle agglutination (PA) assay when compared to that of the indirect immunofluorescence assay using acetone-fixed HTLV-I producing cells (IF-FA). To evaluate the discrepancy between these two screening methods, PA-posi
Manns M; Meyer zum Buschenfelde KH; Arnold W; Medizinische Klinik und Poliklinik,; Johannes-Gutenberg-Universitat Mainz.
Various types of virus induced and non-virus induced chronic active hepatitis (CAH) as well as chronic non-suppurative destructive cholangitis (PBC) and primary sclerosing cholangitis have to be distinguished. Classical autoimmune type lupoid CAH is characterized by antinuclear antibodies (ANA), liver membrane antibod
Lupo G; Spadaro F; Portera M; Torregrossa MV; Russo Alesi D; Vitale F; Romano N; Istituto di Igiene G. D'Alessandro, Universita degli Studi,; Palermo, Italy.
21 HIV strains were isolated from peripheral mononuclear cells of 31 adult and pediatric patients with AIDS or ARC and 10 apparently healthy HIV seropositive individuals. Viral isolation rate was correlated to the clinical status of patients, being very high in patients with AIDS or ARC, and lower in apparently health
Rev Mal Respir. 1988;5(6):551-64. Unique Identifier : AIDSLINE MED/89113935
de Wit S; Van Laethem Y; Clumeck N; Clinique des Maladies Infectieuses, Hopital Universitaire; Saint-Pierre, Bruxelles, Belgique.
After reviewing the immunological anomalies provoked by the human immuno-deficiency virus (HIV) as well as their implications in pulmonary pathology, the authors enumerate the diagnostic and therapeutic methods currently available in the treatment of patients suffering from AIDS and pulmonary diseases. The clinical fe
Said JW; Department of Pathology, Cedars Sinai Medical Center, Los; Angeles, CA 90048.
Lymphoid proliferations in the acquired immunodeficiency syndrome reflect the profound immunologic imbalances induced by the lymphotropic human immunodeficiency virus, and comprise a range of lymphoproliferative disorders from benign lymphadenopathy to malignant lymphoma. Persistent generalized lymphadenopathy (PGL) i
Schweiz Med Wochenschr. 1988 Dec 10;118(49):1838-43. Unique Identifier : AIDSLINE MED/89114338
Fernex M; Recherche clinique, F. Hoffmann-La Roche & Cie SA, Bale.
Some 200 cases of malaria are officially reported yearly in Switzerland . It is estimated that 2000-8000 Swiss travellers are infected by the anopheles mosquito annually, with 90% protected by chemoprophylaxis. An attack of malaria appears to have a better prognosis when the sy
Ivannikova TA; Selimova LM; Korolev MB; Tashenova AA; Zhdanov VM
A comparative evaluation of the effectiveness of detection of human immunodeficiency virus (HIV) in persistently infected culture of T-lymphocytes by means of different morphological and immunomorphological methods: fluorescent antibody method (FAM), immune electron microscopy (IEM), negative staining, and ultrathin s
Ann Otolaryngol Chir Cervicofac. 1988;105(7):543-7. Unique Identifier : AIDSLINE MED/89116796
Pulik M; Lida H; Blanchereau C; Unite d'Hematologie, Centre Hospitalier Victor Dupouy,; Argenteuil.
HIV virus infection is frequently accompanied by polyclonal or monoclonal lymphoid proliferations. The authors report the first case of a tumour of the cavum in a Haitian subject with HIV infection. This large tumour was associated with parotid swelling and a buccal and ocular sicca syndrome. Histological examination
AIDS Res Hum Retroviruses. 1988 Dec;4(6):419-31. Unique Identifier : AIDSLINE MED/89118011
DuBois GC; Samuel KP; Hanson CA; Zweig M; Showalter SD; Papas TS; National Cancer Institute, Frederick Cancer Research Facility, MD; 21701-1013.
The pJL6 expression vector and its derivatives, pJLA16 and pANH-1, have been used for the synthesis and high-level expression in Escherichia coli of restriction enzyme fragments derived from the envelope and 3 -orf genes of the BH10 and BH8 clones, respectively, of the human immunodeficiency virus (HIV-1). These bacte
Pennell JP; Bourgoignie JJ; Health and Human Values Program, University of Miami School of; Medicine, FL 33101.
Should AIDS patients be dialyzed? For asymptomatic HIV carriers and patients with ARC developing renal failure, dialysis is medically beneficial and may delay death from uremia for months or even years. In contrast, dialysis will not prevent a rapid death from AIDS, per se, and thus may be futile. While there may be c
Battjes RJ; Leukefeld CG; Pickens RW; Haverkos HW; National Institute on Drug Abuse, Rockville, Maryland.
Intravenous drug abusers constitute 25 per cent of the cases of the acquired immunodeficiency syndrome (AIDS) in adults in the United States of America and 21 per cent of such cases in Europe. The potential for the rapid spread of the human immunodeficiency virus (HIV) among intravenou
Belec PL; Gresenguet G; Georges-Courbot MC; Villon A; Martin MH; Georges AJ; Institut Pasteur de Bangui, Republique centrafricaine.
A study of several sexually transmitted diseases (STD) (HIV1, HIV2, hepatitis B and syphilis) was performed among high school students and hospitalized patients in Bozoum, a rural town in the Central African Republic (CAR). The rate of injection for each disease (HB
The epidermis possesses everything required for initiation of an immune response. It harbors antigen-presenting Langerhans cells, it produces immune modulatory cytokines, and (so far shown only in the murine system) it contains a distinct T cell population. Both upregulating and downregulating signals, leading to eith
Duggan MJ; Weisenburger DD; Sun NC; Purtilo DT; Department of Pathology and Microbiology, University of Nebraska; Medical Center, Omaha.
We have summarized the findings in selected congenital and acquired immunodeficiency disorders that frequently display blood and bone marrow abnormalities. Many other immunodeficiency syndromes were not discussed, as bone marrow abnormalities are infrequently seen in them. Examination of the bone marrow is not usually
Kageyama S; Yamada O; Mohammad SS; Hama S; Hattori N; Asanaka M; Nakayama E; Matsumoto T; Higuchi F; Kawatani T; et al; Department of Virology, Tottori University School of Medicine,; Yonago, Japan.
The measurement of HIV antigen levels in sera or plasma of HIV-infected individuals is critical for determining the existence of antigen or infectious virus before seroconversion and for prognosis. Pretreatment of sera or plasma of HIV carriers by heating at 70 degrees C for 10 min at an acidic pH enabled us to estima
Ruiz-Arguelles A; Ponce-de-Leon S; Presno-Bernal M; Ponce-de-Leon A; Ortiz-Lopez R; Rojas G; Department of Immunology, Laboratorios Clinicos de Puebla,; Mexico.
Antigenaemia due to human immunodeficiency virus (HIV) is thought to be significant either before the appearance of a specific antibody response, or after its decline during terminal stages. In order to increase the rate of detection of HIV antigen carriers, regardless of the stage or despite the presence of specific
Bagasra O; Freund M; Weidmann J; Harley G; Department of Microbiology, UMDNJ-SOM, Camden 08103.
Transmission of human immunodeficiency virus (HIV) in semen by sexual intercourse is believed to be a major etiological factor in the spread of the disease. In order to explore the role of sperm in this transmission, cell-free HIV-1(IIIB) was coincubated with human sperm for 5 h. After incubation, unattached HIV-1 was
Hay JW; Osmond DH; Jacobson MA; Hoover Institution, Stanford University, CA 94305.
We projected the direct medical costs of acquired immune deficiency syndrome (AIDS) and AIDS-related complex (ARC) for the United States during the period 1987-1991, by applying current epidemiologic projections to state-of-the-art medical decision algorithms for diagnosis and treatmen
Med Trop (Mars). 1988 Oct-Dec;48(4):413-6. Unique Identifier : AIDSLINE MED/89126900
Dechazal L; Goussard B; Salaun JJ; Bernard J; Zagury D; Medecin Chef de l'A.M.T. Francaise, Kinshasa, Zaire.
Serum HIV antibodies has been investigated in different subpopulation from four different regions in Zaire by Elisa (Elavia Pasteur) and Western Blot. Seropositive prevalence differed from 2.4% (rural population) to 12.5% (urban population) according to the regions. When the group
As the numbers of children suffering from AIDS are slowly increasing in West Germany it is essential for pediatricians to be aware of events leading to clinically overt disease. This review summarizes events involved in viral attachment to CD4-bearing cells, intracellular replicat
Donati D; Gastaldi L; Department of Nephrology, General Hospital Varese, Italy.
Uremic patients are at high risk of hepatitis B virus (HBV) infection and, despite the availability and efficacy of hepatitis B vaccine, a high rate of non responders has been reported. Forty uremic patients undergoing maintenance hemodialysis who failed to produce any measurable anti-HBs antibody response after 4 adm
Mann DL; LeSane F; Boumpas D; Dean M; Blattner WA; Biochemical Epidemiology Section, National Cancer Institute,; Bethesda, MD 20892.
We have captured the immunoglobulin genes of CLL cells by fusing the peripheral blood lymphocytes from CLL cells with the B lymphoblastoid line. The hybridoma cell line established from the fusion of CLL cell from two patients who were HTLV-I seropositive produced antibody directed against HTLV-I proteins. The antibod
Piot P; Laga M; Institute of Tropical Medicine, Antwerp.
Female prostitutes are at increased risk for sexually transmitted diseases and HIV infection. However, the prevalence rate of HIV infection among prostitutes varies geographically, with the highest rates occurring in Africa and in areas with large numbers of HIV infected intravenous drug users (IVDU). In Europe the mo
Ann Biol Clin (Paris). 1988;46(9):725-9. Unique Identifier : AIDSLINE MED/89133153
Bonnici JF; Teyssou R; Morvan J; Carteron B; Fleury HJ; du Pasquier P; Laboratoire de Virologie, Hopital Pellegrin, Bordeaux.
The authors have carried out, on 150 sera of patients seropositive for the human immunodeficiency virus type I (HIV I) and 11 cerebrospinal fluid of which 5 were patient infected by the HIV I, a comparative study of two commercial tests for the detection of HIV I antigen (Diagnostic Pasteur and Abbott laboratories). A
Bouza E; Martin-Scapa C; Bernaldo de Quiros JC; Martinez-Hernandez D; Menarguez J; Gomez-Rodrigo J; Cosin J; Sagues-Cifuentes MJ; Servicio de Microbiologia Clinica, Hospital General Gregorio; Maranon, Madrid, Spain.
A total of 67 cases of tuberculosis was diagnosed in the first 100 cases of AIDS, diagnosed according to the former CDC criteria, at a hospital in Madrid, Spain . This is the highest known prevalence of tuberculosis in AIDS patients both within and outside Spain. The clinical manifes
Parks WP; Parks ES; Fischl MA; Leuther MD; Allain JP; Nusinoff-Lehrman S; Barry DW; Makuch RW; Department of Pediatrics, University of Miami School of Medicine,; FL 33136.
Two independent measures of human immunodeficiency virus type 1 (HIV-1) infection, virus isolation, and serum levels of p24 antigen were evaluated in a double-blind randomized clinical trial of the safety and efficacy of a nucleoside analogue, 3 -azido-3 -deoxythymidine (
Thiriart C; Goudsmit J; Schellekens P; Barin F; Zagury D; De Wilde M; Bruck C; Molecular and Cellular Biology Department, Smith Kline-RIT,; Rixensart, Belgium.
A direct enzyme immunoassay (EIA) using the recombinant soluble form of CD4 (sCD4) produced in rodent cells as antigen was applied to detect antibodies to CD4 in sera from HIV-1- and HIV-2-infected patients. High titers of antibodies to sCD4 were found in sera from 12.6% of the HIV-1-infected persons included in this
Chams V; Jouault T; Fenouillet E; Gluckman JC; Klatzmann D; Laboratoire de Biologie et Genetique, Groupe Hospitalier; Pitie-Salpetriere, Paris, France.
The use of purified recombinant soluble CD4 (sT4) allowed the detection of high titers of anti-CD4 immunoglobulins in the sera of three out of 33 HIV-infected patients. Binding of these antibodies to sT4 was first detected by enzyme-linked immunosorbent assay (ELISA), and their reactivity in the assay was blocked in a
Brewer TF; Vlahov D; Taylor E; Hall D; Munoz A; Polk BF; Department of Health Policy and Management, Johns Hopkins; University, Baltimore, Maryland 21205.
To assess the incidence of infection with HIV-1 in the Maryland state prison system, inmates with excess sera stored from specified intake periods between April and June 1985 and 1986 were approached in May 1987 to volunteer for venipuncture. Of the 2286 inmates for whom intake specimens were stored, 1038 (45.4%) no l
Johnson AM; Parry JV; Best SJ; Smith AM; de Silva M; Mortimer PP; Academic Department of Genito-Urinary Medicine, University; College, Middlesex School of Medicine, London.
Saliva specimens were tested for HIV antibody (anti-HIV) by an immunoglobulin G (IgG) antibody capture radioimmunoassay (GACRIA) and three sensitive commercial assays. In tests on 460 seronegative subjects and 196 seropositive subjects GACRIA was 99.8% specific and 100% sensitive. The Wellcome HIV monoclonal and Abbot
Wolk J; Wodak A; Morlet A; Guinan JJ; Wilson E; Gold J; Cooper DA; Albion Street (AIDS) Centre, Surry Hills, Australia.
The contents of needles and syringes returned by intravenous drug users to two Sydney needle and syringe exchange centres were analysed for HIV antibodies by the enzyme-linked immunosorbent assay (ELISA). Reactive and borderline samples were further tested by the Western blot method. Basic demographic and needle shari
Griffin GE; Miller A; Batman P; Forster SM; Pinching AJ; Harris JR; Mathan MM; Department of Communicable Diseases, St George's Hospital Medical; School, London, UK.
Jejunal biopsies from 11 HIV-infected male homosexuals, without secondary enteropathogen infection, were examined at ultrastructural and light microscope level. Subjects were clinically categorized into four groups: asymptomatic (3), AIDS-related complex (4), persistent generalized lymphadenopathy (1), and AIDS (3). A
Ishikawa K; Tsujimoto H; Nakai M; Mingle JA; Osei-Kwasi M; Aggrey SE; Nettey VB; Afoakwa SN; Fukasawa M; Kodama T; et al; Department of Animal Pathology, Tokyo University, Japan.
This report describes the isolation and characterization of a retrovirus of the HIV-2 group from a Ghanaian AIDS patient which has different restriction patterns from previously reported HIV-2 viruses. The virus was morphologically very similar to HIV-1 and HIV-2, and had Mg2+-dependent reverse transcriptase. Like pre
Brook MG; Gor D; Forster SM; Harris W; Jeffries DJ; Thomas HC; Department of Infectious Diseases, Royal Free Hospital, London,; UK.
Five HIV p24 antigen (p24Ag)-positive patients received alpha interferon during trials of therapy for hepatitis B. Four of these showed marked falls in p24Ag during treatment. One of the two patients who became p24Ag-negative [corrected] developed anti-p24 antibodies (anti-p24). Five out of nine p24Ag-negative HIV-ant
BMJ. 1988 Nov 26;297(6660):1363-8. Unique Identifier : AIDSLINE MED/89118572
Gaines H; von Sydow M; Pehrson PO; Lundbegh P; Department of Infectious Disease, Roslagstull Hospital,; Karolinska Institute, Stockholm, Sweden.
The clinical symptoms and signs were assessed in 20 consecutive patients developing infection with the human immunodeficiency virus (HIV). All were male homosexuals and all presented with a glandular-fever-like illness. Changes in laboratory values were compared with findings in 40 HIV negative male homosexual control
Naik SP; Samsonoff WA; Ruck RE; Wadsworth Center for Laboratories and Research, New York State; Department of Health, Albany 12201-0509.
The multiple-drug-resistance property of Mycobacterium avium complex (MAC) is mainly attributed to a cell envelope permeability barrier. MAC treated with subinhibitory levels of dimethyl sulfoxide (DMSO) and ethylenediaminetetraacetic acid (disodium salt) (EDTA) did not have altered minimum inhibitory concentration (M
Lindhardt BO; Pedersen C; Ulrich K; Kusk P; Laboratory of Tumor Virology, Fibiger Institute, Copenhagen,; Denmark.
The native major core protein p24 of the human immunodeficiency virus (HIV) was immunoaffinity purified by a monoclonal antibody and used to develop an indirect enzyme-linked immunosorbent assay (inELISA) for detecting p24 antibodies in human sera. Its ability to detect p24 antibodies was compared to that of the immun
Sei Y; Tsang PH; Roboz JP; Sarin PS; Wallace JI; Bekesi JG; Department of Neoplastic Diseases, Mount Sinai School of; Medicine, New York, New York 10029.
A double-blind longitudinal study for the presence of human immunodeficiency virus type 1 (HIV-1) neutralizing antibodies (NAb) in the sera of 36 patients with acquired immune deficiency syndrome (AIDS), 149 prodromal homosexual subjects, and 33 heterosexual subjects has been carried out. All AIDS patients and 68% of
Braun DP; Kessler H; Falk L; Paul D; Harris JE; Blaauw B; Landay A; Department of Internal Medicine, Rush-Presbyterian-St. Luke's; Medical Center, Chicago, Illinois 60612.
Various aspects of monocyte-associated function were evaluated in the peripheral blood mononuclear cells of male homosexuals who were infected with the human immunodeficiency disease virus (HIV). The functional assessments included indomethacin-sensitive regulation of blastogenesis and lymphokine-activated killer (LAK
Int J Lepr Other Mycobact Dis. 1988 Dec;56(4):546-51. Unique Identifier : AIDSLINE MED/89124565
ShivRaj L; Patil SA; Girdhar A; Sengupta U; Desikan KV; Srinivasan H; Central JALMA Institute for Leprosy (ICMR), Taj Ganj, Agra,; India.
Sera from 478 persons (348 leprosy patients, 33 tuberculosis patients, 29 healthy contacts of leprosy patients, 38 normal healthy Indians, and 30 normal healthy Europeans) were screened for anti-HIV-1 IgG antibodies by ELISA. None was positive. In addition, 132 samples (from 43 leprosy patients, 21 tuberculosis patien
Reddy MM; Sorrell SJ; Lange M; Grieco MH; R. A. Cooke Institute of Allergy, St. Luke's-Roosevelt Hospital; Center, New York, NY 10019.
Tumor necrosis factor (TNF) and HIV P24 antigen levels were determined in the serum of intravenous drug abusers (IVDAs), homosexuals, and patients with lymphadenopathy or acquired immune deficiency syndrome (AIDS). The mean TNF level in the serum of normal controls was 12 +/- 5 compared to 112 +/- 25 pg/ml in the seru
Imbasciati E; De Cristofaro V; Sama F; Pagliari B; Baretta A; Servizio di Nefrologia, Ospedale di Sondrio, Italy.
We describe the clinical course of a 39-year-old man who developed AIDS during maintenance haemodialysis. The infection had been transmitted by cadaveric kidney transplantation from a donor with a history of i.v. drug abuse. Fever, splenomegaly, hypergammaglobulinaemia and thrombocytopenia were the first signs, and ap
Wong VK; Ross LA; Division of Infectious Diseases, Children's Hospital of Los; Angeles, California.
Branhamella catarrhalis was isolated in blood culture from a 6-month-old infant with AIDS. The child had a nasopharyngeal infection with respiratory syncytial virus and pneumonitis with Pneumocystis carinii. Commensal organisms such as B. catarrhalis may be potential pathogens in infants with AIDS.
Hodges LC; Poteet GW; School of Nursing, East Carolina University, Greenville, NC; 27858-4353.
Publication in professional journals has become an expectation not only of neuroscience nurse educators but practitioners as well. Through publication, the neuroscience nurse demonstrates commitment to the profession and specialty area by sharing clinical insights and knowledge with colleagues practicing in the field.
Parenti DM; Simon GL; Scheib RG; Meyer WA 3d; Sztein MB; Paxton H; DiGioia RA; Schulof RS; Division of Infectious Diseases, George Washington University; Medical Center, Washington, DC 20037.
Ten homosexual men received oral lithium carbonate at doses that maintained their serum lithium concentrations between 0.5 and 1.5 mEq/L. Prior to treatment all patients had HIV isolated from PHA-activated peripheral blood lymphocytes (PBLs) using a quantitative antigen-capture enzyme-linked immunosorbent assay (ELISA
Studies were carried out on the effectiveness of ribamidil, sodium phosphonoformate, cortisone, and deksazon as inhibitors of human immunodeficiency virus (HIV) reproduction which was tested by immunofluorescence. The drugs were screened in H9/IIIB culture permissively infected with HIV virus, and in H9 culture subseq
Hagler DN; Deepe GS; Pogue CL; Walzer PD; Cincinnati VA Medical Center, University of Cincinnati College of; Medicine, OH 45220.
Proliferative responses by human peripheral blood mononuclear cells and rat spleen cells were measured to Pneumocystis carinii in a blastogenic assay using organisms obtained from rat lungs and propagated in tissue culture as the antigen. Responses occurred only in subjects with known prior exposure to P. carinii and
Katz JD; Nishanian P; Mitsuyasu R; Bonavida B; Department of Microbiology & Immunology, UCLA School of Medicine; 90024.
The acquired immunodeficiency syndrome (AIDS) is defined in clinical terms by the development of Kaposi s sarcoma and/or severe opportunistic infections in persons without predisposing conditions. A hallmark of the syndrome has been a decrease in the number of CD4+ T helper cells. The reduction in the frequency of the
Ziegler-Heitbrock HW; Stachel D; Schlunk T; Gurtler L; Schramm W; Froschl M; Bogner JR; Riethmuller G; Institute for Immunology, University of Munich, F.R.G.
In a selected group of human immunodeficiency virus (HIV)-infected patients we confirm the expansion of a CD8+ T-lymphocyte subset, i.e., the CD8+/Leu7+ cells, which account for 30% of the lymphocytes, compared to 3% in the control donors. In addition, a CD8+ T-lymphocyte subset that coexpresses class II (DR) antigens
Carbohydr Res. 1988 Dec 1;183(2):261-75. Unique Identifier : AIDSLINE MED/89106164
Agyei-Aye K; Baker DC; Department of Chemistry, University of Alabama, Tuscaloosa; 35487-0336.
A series of 1-(3-alkyl-2,3-dideoxy-alpha,beta-D-erythro-pentofuranosyl)thymin- es (3 -alkyl-3 -deoxythymidines) has been prepared from 5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-D-glycero-pent-2- enono-1,4-lactone ((S)-5-[(tert-butyldiphenylsilyl)oxymethyl]-2(5H)- furanone) by Michael addition of the appropriate organo
Fuchs D; Hausen A; Reibnegger G; Werner ER; von Dittrich P; Wachter H; Institute of Medical Chemistry and Biochemistry, University of; Innsbruck, Austria.
We studied 20 patients on long-term hemodialysis. Concentrations of neopterin and creatinine were quantified in serum and in exchange buffers before, during and after treatment sessions. Neopterin is a low molecular weight product released by human macrophages upon stimulation with interferon gamma. It permits the qua
Farrar WL; Harel-Bellan A; Ferris DK; Biochemical and Molecular Neuroimmunology, National Cancer; Institute, Frederick, Maryland.
The CD4 surface determinant, previously associated as a phenotypic marker for helper/inducer subsets of T lymphocytes, has now been critically identified as the binding/entry protein for human immunodeficiency viruses (HIV). The human CD4 molecule is readily detectable on monocytes, T lymphocytes, and brain tissues. S
Taylor DL; Taylor-Robinson D; Jeffries DJ; Tyms AS; Department of Medical Microbiology, St Mary's Hospital Medical; School, Paddington, London.
Thirty-seven isolates of cytomegalovirus ( CMV ) were obtained from a group of 20 promiscuous homosexual men, either suffering from the acquired immunodeficiency syndrome (AIDS) at the time of CMV isolation, or who developed AI
Gene. 1988 Nov 15;71(1):207-10. Unique Identifier : AIDSLINE MED/89108041
Schweinfest CW; Jorcyk CL; Fujiwara S; Papas TS; Laboratory of Molecular Oncology, National Cancer Institute,; Frederick, MD 21701-1013.
We describe a construct, pHS/Cla, containing the Drosophila melanogaster hsp70 promoter which serves as an inducible expression vector in mammalian cells. The construct was made in the plasmid pAT153, a derivative of pBR322. In transient transfections of human H9 T-cells, the transactivator of transcription protein of
Ugawa Y; Kohara N; Shimpo T; Mannen T; Department of Neurology, School of Medicine, University of Tokyo,; Japan.
Central motor and sensory conduction was studied by percutaneous electrical stimulation of brain and spinal cord and by somatosensory evoked potential techniques respectively, in patients with adrenoleukomyeloneuropathy, cerebrotendinous xanthomatosis, human T-cell lymphotropic virus-1-associated myelopathy and tabes
Schweiz Med Wochenschr. 1988 Dec 10;118(49):1830-7. Unique Identifier : AIDSLINE MED/89114337
Hirschel B; Division des maladies infectieuses, Hopital cantonal; universitaire, Geneve.
Acyclovir ( Zovirax ) and zidovudine (Retrovir) dominate antiviral therapy. They interfere with the multiplication of herpes viruses (acyclovir) and HIV (zidovudine) by incorporation into nascent DNA chains and interruption of the further li
Furukawa Y; Nakamura H; Sakamoto S; Miura Y; Department of Medicine, Jichi Medical School, Tochigi-ken, Japan.
A 39-year-old woman was admitted to the hospital because of epigastric pain and diagnosed as having gastritis. After 3 months, she developed generalized lymphadenopathy, and a biopsy revealed diffuse proliferation of CD4 positive lymphoid cells. She was positive for human T-cell leukemia virus type-I antibody and the
The human spumaretrovirus (HSRV) isolated from a nasopharynx carcinoma patient 17 years ago has a RNA genome 11 kb in size. It encodes besides the gag, pol, and env genes several novel genes (S1 and bel 1, 2, and 3) that are comparable to the regulatory genes R, X, tat, art, and 3 -orf of the human (HIVs) and simian i
Robbins KC; King CR; Giese NA; Leal F; Igarashi H; Aaronson SA; Laboratory of Cellular and Molecular Biology, National Cancer; Institute, Bethesda, Maryland 20892.
Chirmule N; Kalyanaraman V; Oyaizu N; Pahwa S; Department of Pediatrics, North Shore University Hospital,; Cornell University Medical College, Manhasset, NY 11030.
Infection with the human immunodeficiency virus (HIV-1) leads to a wide range of immunological abnormalities. We have shown that native envelope glycoproteins (gp120) of HIV-1 inhibit antigen-specific and anti-CD3 induced lymphoproliferation of normal lymphocytes. We have demonstrated that gp120 binds to CD4 positive
Dayton AI; Terwilliger EF; Potz J; Kowalski M; Sodroski JG; Haseltine WA; Department of Pathology, Harvard Medical School, Dana-Farber; Cancer Institute, Boston, MA 02115.
Expression of high levels of the structural proteins of the human immunodeficiency virus type 1 (HIV-1) requires the presence of two regulatory genes, the trans-activator (tat), and the regulator of virion protein expression (rev. previously called art or trs). The experiments described here show that expression of vi
Klatt EC; Department of Pathology, University of Southern California School; of Medicine, Los Angeles.
The clinical and autopsy findings documented in 216 patients with the acquired immune deficiency syndrome (AIDS) are summarized. The respiratory system was most often involved with opportunistic infections and neoplasms diagnostic of AIDS, accounting for one-fourth of all such occurrences. Respiratory failure was the
Med Trop (Mars). 1988 Oct-Dec;48(4):375-9. Unique Identifier : AIDSLINE MED/89126894
Ouattara SA; Diallo D; Meite M; Aron Y; Akran V; Gody M; Schmidt D; Tolstuchow N; De-The G; Institut Pasteur de Cote d'Ivoire, Faculte de Pharmacie,; l'Universite d'Abidjan.
A study of antibodies to HIV1 and HIV2 has been performed among selected groups in Ivory Coast from January to December 1987. In total, 2,578 serum samples were examined. A seropositivity to HIV1 and/or HIV2 was observed in 32 (2.4%) of 1.334 healthy subjects of the general po
The effect of different dosages of ganciclovir on proved cytomegalovirus chorioretinitis was tested in a randomized trial on 11 homosexual men with AIDS. The effect of 5 mg/kg/day was as good as 10 mg/kg/day. The lower dosage had less toxicity.
Petitjean J; Khayat MC; Laforet F; Quibriac M; Freymuth F; Khayat A; Evrard C; Thomas M; Laboratoire de virologie, CHU de Caen.
The incidence of post-transfusion viral contamination after cardiac surgery is variable but not negligible. The serological and clinical features of such contamination were determined in a series of 100 consecutive patients seen between June, 1983 and January, 1984. The ELISA technique was used for hepatitis A and B v
Parisi G; Dipartimento di Fisica, Universita di Roma Tor Vergata.
In this note, we first review some of the immunopathogenic mechanisms of HIV infection and discuss the possible role of the idiotypic network in producing immunodeficiency; we then propose that the interaction of HIV with the nervous system is such as to generate signals which are misinterpreted by the nervous system:
Evans R; Shanson DC; Department of Clinical Microbiology, St Stephen's Hospital,; London.
Between 1982 and July 1987, more than 1200 patients attending St Stephen s Hospital were found to be HIV antibody positive. Four hundred were inpatients and most of the outpatients attended the sexually transmitted disease clinic. Two hundred and twenty-one patients had AIDS, 480 HIV-related disorders and 500 were asy
Bottiger B; Palme IB; da Costa JL; Dias LF; Biberfeld G; Department of Immunology, National Bacteriological Laboratory,; Stockholm, Sweden.
A seroepidemiological study of human immune deficiency virus type 1 (HIV-1) and HIV-2/human T-lymphotropic virus type IV (HIV-2/HTLV-IV) infections was performed in Angola in October 1986. Until then five cases of acquired immune deficiency syndrome (AIDS) had been registered in An
We performed a randomized, double-blind, placebo-controlled trial to assess the tolerance and efficacy of recombinant human interferon alpha 2a (Roferon A) in patients with acquired immunodeficiency syndrome (AIDS) without Kaposi s sarcoma. A total of 67 patients were enrolled in five medical centers from October 1983
Detels R; English PA; Giorgi JV; Visscher BR; Fahey JL; Taylor JM; Dudley JP; Nishanian P; Munoz A; Phair JP; et al; Multicenter AIDS Cohort Study, National Institute of Allergy and; Infectious Disease, Bethesda, Maryland.
Successive interval slopes of CD4+ cells each constructed from levels at three consecutive 6 month visits were compared over 3 years of follow-up among 565 persistently HIV-1 antibody-positive, 326 persistently antibody-negative, and 51 seroconverting homosexual men who had at least 500 CD4+ cells/mm3 at baseline and
Munoz A; Carey V; Saah AJ; Phair JP; Kingsley LA; Fahey JL; Ginzburg HM; Polk BF; Department of Epidemiology, Johns Hopkins School of Public; Health, Baltimore, MD 21205.
Longitudinal data on four visits scheduled at 6 month intervals were available on a cohort of 1,827 homosexual men who were human immunodeficiency virus (HIV) seropositive at entry. To identify predictors of the rate of decline of CD4 T-lymphocytes, we used an autoregressive model that relates CD4 counts to predictor
From 1985 to 1987 101 patients infected with the human immunodeficiency virus (HIV) were seen at our outpatient clinic and prospectively analyzed in a cohort study. We evaluated the follow-up in 41 patients of CDC classes II and III with regard to the number of T-helper lymphocytes (T4) and clinical progression. The p
Immunohistochemistry is finding an ever increasing application for electron microscopic diagnosis of human viral diseases. Certain progress has been made in the use of peroxidase-DAB/OsO4 as an electron-dense marker, and colloid gold. The paper discusses immunohistochemistry application for electron microscopic detect
The serological study of 20 sera, showing atypical reaction with HIV-1 in the immunoblotting assay, for the presence of HIV-2 infection revealed some cases of this infection among Africans who had arrived to the USSR from Western Africa (5 cases) and Burundi (1 case); besides, in
AIDS Res Hum Retroviruses. 1988 Dec;4(6):433-40. Unique Identifier : AIDSLINE MED/89118012
De Wolf F; Roos M; Lange JM; Houweling JT; Coutinho RA; van der Noordaa J; Schellekens PT; Goudsmit J; Department of Virology, University of Amsterdam.
Changes in CD4+ cell numbers were studied in relation to the presence of HIV-1 antigen (HIV-1-Ag) in serum from homosexual men followed prospectively. During 30 months of follow-up the mean CD4+ cell number (x 10(9) per liter) was stable in 134 at entry HIV-1 antibody (HIV-1-Ab) seropositives, who remained HIV-1-Ag ne
De Clercq E; Rega Institute for Medical Research, Katholieke Universiteit; Leuven, Belgium.
Several steps in the replicative cycle of human immunodeficiency virus (HIV) could be envisaged as targets for anti-AIDS drugs. The anionic compound PMEA [9-(2-phosphonyl-methoxyethyl)adenine], the 2 3 -dideoxynucleoside analogues D4T (2 ,3-deidehydro-2 ,3 -dideoxythymidine), AzddUrd 3 -azido-2 ,3 -dideoxyuridine), Fd
Michel F; Hoffenbach A; Langlade-Demoyen P; Guy B; Girard M; Lecocq JP; Wain-Hobson S; Kieny MP; Plata F; Laboratoire de Biologie et d'Immunologie Moleculaires des; Retrovirus, Institut Pasteur, Paris, France.
Infection by the human immunodeficiency virus (HIV) induces T cell immunity in humans, chimpanzees and macaques. The protective value of this immune response is not clear. We have consequently developed a murine experimental system to study HIV-specific CD4 and CD8 T lymphocyte immunity in vitro and in vivo. BALB/c, D
The new D-mannose-specific lectin from Gerardia savaglia is shown to prevent infection of H9 cells with human immunodeficiency virus type 1 (HIV-1; strain HTLV-IIIB). At a concentration of 0.2 microM, complete protection was achieved. Even at a 50-fold higher concentration, this lectin is not toxic for the cells. More
Can Nurse. 1989 Jan;85(1):34-7. Unique Identifier : AIDSLINE MED/89106104
Laurin JC
Prevention, why resist it? Based on a 1988 speech the author gave to infection control professionals in Montreal, this article draws a parallel between individuals resistance to change and their reaction to infection control programs. Gladly, many of the same well-honed techniques that help change along can be applie
Viscidi RP; O'Meara C; Farzadegan H; Yolken R; Department of Medicine, Johns Hopkins University School of; Medicine, Baltimore, Maryland 21205.
In this report we describe a novel, nonisotopic hybridization assay for the measurement of viral RNA in biological samples. The assay involved a solution-phase reaction between a biotinylated DNA probe and RNA target sequences. Labeled hybrids were detected in an immunoreaction by using a solid-phase anti-biotin antib
Vasudevachari MB; Uffelman KW; Mast TC; Dewar RL; Natarajan V; Lane HC; Salzman NP; Division of Molecular Virology and Immunology, Georgetown; University School of Medicine, Washington, D.C. 20007.
A passive hemagglutination test (PHA) was developed for detecting antibodies to human immunodeficiency virus type 1 (HIV-1) utilizing sheep erythrocytes cross-linked with purified envelope glycoprotein (gp160) of HIV-1. In an analysis of 216 human serum samples, 100% correlation was observed in 86 reactive and 124 non
Rappocciolo G; Toso JF; Torpey DJ 3d; Gupta P; Rinaldo CR Jr; Department of Infectious Diseases and Microbiology, Graduate; School of Public Health, University of Pittsburgh, Pennsylvania; 15261.
Mononuclear leukocytes from human immunodeficiency virus (HIV)-seronegative and -seropositive homosexual men lysed HIV-infected U937 cells to a significantly greater degree than uninfected U937 cells. Depletion of cell subsets with monoclonal antibodies and complement indicated that the effector cells were primarily o
Gallo D; Kimpton JS; Johnson PJ; Viral and Rickettsial Disease Laboratory, State of California; Department of Health Services, Berkeley 94704.
The peripheral blood lymphocytes from 48 heparinized blood specimens from human immunodeficiency virus (HIV) antibody-positive individuals were divided into two aliquots. One aliquot was reconstituted in one of the following five media. Medium 1 consisted of tryptose broth with 0.5% gelatin; medium 2 consisted of RPMI
Hogan D; Card RT; Ghadially R; McSheffrey JB; Lane P; Department of Medicine, University of Saskatchewan, Saskatoon,; Canada.
A recent report documents three homosexual men with porphyria cutanea tarda associated with acquired immune deficiency syndrome (AIDS). We report two brothers with hemophilia and human immunodeficiency virus (HIV) exposure who developed porphyria cutanea tarda. These brothers are heterosexual, have familial porphyria
Kaplan MH; Sadick NS; Wieder J; Farber BF; Neidt GW; Department of Medicine, Cornell University Medical College, North; Shore University Hospital, Manhasset, NY 11030.
Four patients with psoriasis complicating human immunodeficiency virus (HIV) infection showed marked improvement in their psoriasis after being treated with oral zidovudine. The antipsoriatic effect persisted in two patients in spite of worsening helper T cell depletion. The antipsoriatic effect appeared to be dose-de
Jin ZW; Cleveland RP; Kaufman DB; Department of Pediatrics and Human Development, Michigan State; University, East Lansing 48824.
Nineteen patients with hemophilia, five of whom were classified as untreated, were immunologically evaluated by the measurement of cell surface markers, natural killer cell activity, mitogenic responses, polyclonal immunoglobulin production, and serologic evidence of human immunodeficiency virus infection. No correlat
A battery of once-obscure drugs is buying time for AIDS patients. Expect toxicity when you administer them, and know the interventions that can keep the patient s discomfort at a minimum.
Am J Hematol. 1989 Feb;30(2):68-76. Unique Identifier : AIDSLINE MED/89116145
Lawrence DN; Jason JM; Holman RC; Heine P; Evatt BL; Division of Host Factors, Centers for Disease Control, Atlanta,; GA.
We assessed the risk of human immunodeficiency virus (HIV) transmission from heterosexual seropositive hemophilic men to their female sex partners through an HIV serosurvey and questionnaire study conducted during 1984-1987. Five percent of 21 female partners of asymptomatic men and 11% of 35 partners of HIV-symptomat
The presence of HIV gag and env proteins (HIV Ag) and virus replicating cells was studied by immunohistochemistry and in situ hybridization, respectively, in brain specimens from five HIV infected patients. HIV antigens were detected in 3 of 5 brains in micronodular areas characterized by increased cellularity and the
Josefsen D; Myrmel H; Department of Microbiology and Immunology, Gade Institute,; Haukeland Hospital, Bergen, Norway.
A new test for rapid detection of HIV antibodies (HIVCHEK) was evaluated. A total of 107 sera were examined. Of these, 60 were from healthy blood donors and the rest from a serum panel containing HIV positives and samples with false positive reactions in ELISA and unspecific bands in the western blot (WB). There was c
Can Nurse. 1989 Feb;85(2):35-7. Unique Identifier : AIDSLINE MED/89119410
Pelletier PG
An alternative approach to AIDS in Zambia . Zambians have lived with what we now call AIDS for 20 years. Today, an estimated eight percent of newborns are infected with the virus. Yet dealing with AIDS in this traditional society is an onerous task. While the country s 10,000 nurses
Soni A; Agarwal A; Chander P; Yoo J; Singal D; Salomon N; Robinson B; Treser G; Department of Internal Medicine, New York Medical College,; Lincoln Medical Center, Bronx 10451.
The existence of an HIV-related nephropathy as a distinct disease entity is controversial. We observed a high incidence of renal disease in our AIDS patients. Of 182 patients, 59 patients (32.4%) were found to have heavy proteinuria (greater than 2 g/24 h). Of these, 24 patients had slow progression of renal insuffici
Crit Care Med. 1989 Feb;17(2):113-7. Unique Identifier : AIDSLINE MED/89120146
Rogers PL; Lane HC; Henderson DK; Parrillo J; Masur H; Critical Care Medicine Department, National Institute of Allergy; and Infectious Disease, Bethesda, MD.
As the number of cases of AIDS increases, it is important to determine whether ICUs can be productively and safely used for this patient population. From July 1981 to March 1987, 216 patients were admitted to the medical ICU: 166 (77%) were admitted for procedures and 50 (23%) were admitted for life-sustaining support
This study examined the effect that knowledge of a student having AIDS (Acquired Immune Deficiency Syndrome) would have on regular-education teacher judgment regarding special education placement. Regular-education, third-grade teachers in Indiana were sent one of two psychological reports. The reports were identical
Hosp Community Psychiatry. 1989 Feb;40(2):153-7. Unique Identifier : AIDSLINE MED/89121918
Cournos F; Empfield M; Horwath E; Kramer M; Washington Heights Community Service, New York State Psychiatric; Institute, New York 10032.
Patients with AIDS and related illnesses are entering state mental hospitals in increasing numbers. State hospitals in New York City generally did not plan for patients infected with human immunodeficiency virus (HIV) until the first patient appeared; however, over the past five years, approaches to managing these pat
Hosp Community Psychiatry. 1989 Feb;40(2):158-61. Unique Identifier : AIDSLINE MED/89121919
Perry S; Consultation-Liaison Service, New York Hospital-Cornell Medical; Center, New York 10021.
The American Psychiatric Association has adopted a policy stating that psychiatrists may warn third parties who are placed at risk by the behavior of a patient infected with human immunodeficiency virus (HIV). The author argues that although the policy appears reasonable and has well-established precedent, the public
Hosp Community Psychiatry. 1989 Feb;40(2):162-4. Unique Identifier : AIDSLINE MED/89121920
Zonana H; Yale University School of Medicine, New Haven, Connecticut 06519.
The author argues that the American Psychiatric Association s AIDS policy on confidentiality and disclosure provides reasonable guidelines for psychiatrists struggling to balance their obligation to maintain the confidentiality of individual patients infected with human immunodeficiency virus (HIV) with their obligati
Dominey A; Rosen T; Tschen J; Veterans Administration Medical Center, Houston, TX 77211.
We describe a papulonodular variant of demodicidosis seen in two patients with acquired immunodeficiency syndrome and its successful treatment with 1% gamma benzene hexachloride and 1% permethrin cream rinse. Alterations in T cell function may allow otherwise commensal organisms to proliferate to the point of causing
Ghadially R; Sibbald RG; Walter JB; Haberman HF; Department of Dermatology, University of Toronto, Ontario,; Canada.
We present four cases of granuloma annulare occurring in patients with human immunodeficiency virus (HIV) infection. These patients had either an extensive localized form or generalized granuloma annulare. The patient with generalized granuloma annulare was clinically reminiscent of the previously described papular er
Up to 31 March 1988, 1429 cases meeting the World Health Organization /Centers for Disease Control (U.S.A.) definition of the acquired immune deficiency syndrome (AIDS) were reported in the U.K. of which 59 were in visitors and 1370 in U.K. residents. In the same period there were 8459
Williams I; Gabriel G; Cohen H; Williams P; Tedder RS; Machin S; Weller IV; Academic Department of Genitourinary Medicine, University College; and Middlesex School of Medicine, London, U.K.
Cowan FM; Jones G; Bingham J; Flegg PJ; MacCallum LR; Whitelaw J; Hargreave D; Gray JA; Welsby PD; Brettle RP; Department of Infectious Diseases, City Hospital, Edinburgh, U.K.
The use of zidovudine in drug misusers, especially current drug misusers, has not been extensively studied. Since periods of abstinence may be interspersed with drug misuse, it is necessary to establish the safety of zidovudine in injection drug misuse-related human immunodeficiency virus (HIV) infection under a varie
Fox CH; Kotler D; Tierney A; Wilson CS; Fauci AS; Laboratory of Immunoregulation, National Institute of Allergy and; Infectious Diseases, Bethesda, Maryland 20892.
Thirty formaldehyde-fixed, paraffin-embedded endoscopic biopsy specimens from the colon and rectum of 25 patients with acquired immunodeficiency syndrome were examined using a [35S]HIV-RNA in situ hybridization procedure. Nine of the specimens contained cells that bound significant amounts of probe. Cells were conside
Rutherford GW; Schwarcz SK; Lemp GF; Barnhart JL; Rauch KJ; Warner WL; Piland TH; Werdegar D; AIDS Office, San Francisco Department of Public Health,; California 94103.
Weinke T; Rogler G; Sixt C; de Matos-Marques B; Pohle HD; Staib F; Seibold M; Universitatsklinikum Rudolf Virchow, II. Medizinische Klinik,; Berlin.
The clinical course and response to therapy of seven patients with cryptococcosis and AIDS were reviewed. One patient was still in the primary stage of cryptococcosis in AIDS, i.e. the stage that is characterized by the sole cultural detection of Cryptococcus neoformans in the respiratory tract. The other six patients
Mathews WC; Linn LS; Robert Wood Johnson Clinical Scholars Program, UCLA School of; Medicine.
To assess attitudes toward educational programs about AIDS, 540 patients and 36 of their medical providers in primary care clinics were systematically sampled to ascertain what age groups should be exposed to a pamphlet entitled Am I at Risk for AIDS?, as well as what was acceptable content for posters and pamphlets p
Clavel F; Hoggan MD; Willey RL; Strebel K; Martin MA; Repaske R; Laboratory of Molecular Microbiology, National Institute of; Allergy and Infectious Diseases, Bethesda, Maryland 20892.
We investigated genetic recombination of the human immunodeficiency virus (HIV) in a tissue culture system. A clonal cell line expressing a single integrated HIV provirus with a termination codon affecting pol gene expression was transfected with different defective mutants derived from an infectious molecular clone o
JAMA. 1989 Feb 17;261(7):1008-12. Unique Identifier : AIDSLINE MED/89125784
Des Jarlais DC; Friedman SR; Novick DM; Sotheran JL; Thomas P; Yancovitz SR; Mildvan D; Weber J; Kreek MJ; Maslansky R; New York State Division of Substance Abuse Services, NY 10013.
Intravenous drug users are the second largest group to develop the acquired immunodeficiency syndrome, and they are the primary source for heterosexual and perinatal transmission in the United States and Europe. Understanding long-term trends in the spread of human immunodeficiency vir
JAMA. 1989 Mar 3;261(9):1289-94. Unique Identifier : AIDSLINE MED/89125855
Selwyn PA; Schoenbaum EE; Davenny K; Robertson VJ; Feingold AR; Shulman JF; Mayers MM; Klein RS; Friedland GH; Rogers MF; Department of Epidemiology and Social Medicine, Montefiore; Medical Center, Bronx, NY 10467-2490.
To determine the effects of human immunodeficiency virus (HIV) infection on pregnancy outcomes, we prospectively studied female intravenous drug users in a methadone program in New York City. Of 191 women with HIV status known prior to pregnancy, 17 (24%) of 70 seropositives and 26 (22%) of 121 seronegatives became pr
N Engl J Med. 1989 Mar 2;320(9):545-50. Unique Identifier : AIDSLINE MED/89127440
Selwyn PA; Hartel D; Lewis VA; Schoenbaum EE; Vermund SH; Klein RS; Walker AT; Friedland GH; Department of Epidemiology and Social Medicine, Montefiore; Medical Center-Albert Einstein College of Medicine, New York; 10467.
To determine the risk of active tuberculosis associated with human immunodeficiency virus (HIV) infection, we prospectively studied 520 intravenous drug users enrolled in a methadone-maintenance program. Tuberculin skin testing and testing for HIV antibody were performed in all subjects. Forty-nine of 217 HIV-seroposi
Uematsu T; Hanada S; Saito T; Otsuka M; Komidori K; Osaki K; Uemura S; Ueda H; Harada R; Hashimoto S; Second Department of Internal Medicine, Faculty of Medicine,; Kagoshima University, Japan.
We report 2 cases of adult T cell leukemia (ATL) from hemodialysis (HD) patients with chronic renal failure (CRF) in the Kagoshima district, an endemic area of human T cell leukemia virus type I(HTLV-I) in Japan . The positivity of antibodies to ATL-associated antigen(anti-ATLA) in H
Rhyner K; Egli F; Niemoller M; Wieczorek A; Greminger P; Vetter W; Departement fur Innere Medizin, Universitatsspital Zurich,; Schweiz.
The accurate radioimmunological measurement of serum erythropoietin (EPO) levels has only been possible since the development of highly specific antibodies directed against recombinant human EPO. In the present study, we determined the serum EPO levels in 100 healthy volunteers and in over 300 patients with anemias an
Dickson DW; Belman AL; Kim TS; Horoupian DS; Rubinstein A; Department of Pathology (Neuropathology), Albert Einstein College; of Medicine, Bronx, NY 10461.
We examined the spinal cords from 15 consecutive autopsies of infants and children with AIDS using a battery of histochemical and immunocytochemical stains, and in four cases, electron microscopy. Corticospinal tract (CST) signs were a notable clinical finding in 14; however, the age of onset, rate of progression, sev
Lenhardt TM; Wiley CA; Laboratory Department, Naval Hospital, San Diego, La Jolla, CA.
The pathogenesis of CNS damage by human immunodeficiency virus infection is unclear. Because there is little detectable virus within the CNS, we evaluated the role of the humoral immune system in mediating CNS tissue destruction. The paucity and nonspecific nature of immunoglobulin deposition rules against significant
Mazzarello MG; U.S.S.L. n. 74, Ospedale Sant'Antonio, Ovada, Alessandria.
AIDS (acquired immune deficiency syndrome) is a disease of major medical, epidemiological, psychological and social importance. Its aetiological agent is one of the retroviruses that attacks the individual s immune system and destroys its ability to combat other diseases. The available virological data make it clear t
LaRaja RD; Rothenberg RE; Odom JW; Mueller SC; Department of Surgery, Cabrini Medical Center, New York, N.Y.; 10003.
This communication concerns the incidence of intra-abdominal surgery in 904 patients with acquired immunodeficiency syndrome who were admitted to the Cabrini Medical Center during a 3-year period from January 1985 to January 1988. It was found that 36, or 4.2%, of the patients underwent surgery, including 12 cholecyst
Lelie PN; van der Poel CL; Reesink HW; Huisman HG; Boucher CA; Goudsmit J; Central Laboratory of the Netherlands Red Cross Blood Transfusion; Service, Red Cross Bloodbank, Amsterdam.
Jacobson MA; Isenberg WM; Department of Medicine, University of California, San Francisco.
Mycobacterium kansasii is a rare cause of disseminated mycobacterial infection in patients with the acquired immune deficiency syndrome (AIDS). It occurs as the index AIDS diagnosis in only 0.2% of AIDS cases. Previously reported cases of AIDS-associated M. kansasii infection have manifested as diffuse interstitial pn
Am J Gastroenterol. 1989 Feb;84(2):143-6. Unique Identifier : AIDSLINE MED/89132496
Porro GB; Parente F; Cernuschi M; Department of Infectious Diseases, L. Sacco Hospital, Milan,; Italy.
Oral and esophageal candidiasis represents a common infection in patients with acquired immune deficiency syndrome (AIDS). Because the relationship between the infection in both sites is not well known, we submitted to routine upper digestive endoscopy 57 patients with AIDS. Furthermore, we evaluated the diagnostic ac
Am J Gastroenterol. 1989 Feb;84(2):195-7. Unique Identifier : AIDSLINE MED/89132509
Ozick L; Chander P; Agarwal A; Soni A; Department of Medicine, New York Medical College, Lincoln; Hospital, Bronx.
Tubuloreticular inclusions (TRI) are known to be associated with viral infections and are considered highly specific of the acquired immune deficiency syndrome (AIDS) in the appropriate clinical setting. We describe a homosexual man without any evidence of AIDS who presented with diarrhea. A search for the usual patho
Am J Epidemiol. 1989 Mar;129(3):596-603. Unique Identifier : AIDSLINE MED/89132539
van Griensven GJ; de Vroome EM; Tielman RA; Goudsmit J; de Wolf F; van der Noordaa J; Coutinho RA; Municipal Health Service, Dept. of Public Health and Environment,; Amsterdam, The Netherlands.
For the study of the impact of human immunodeficiency virus (HIV) antibody testing on high-risk sexual behavior with nonsteady and steady sexual partners, 307 homosexual men (118 seronegative, 75 seropositive, and 114 untested) were interviewed at three consecutive six-month intervals between July 1985 and December 19
Ann Intern Med. 1989 Mar 1;110(5):365-8. Unique Identifier : AIDSLINE MED/89133267
Oksenhendler E; Bierling P; Ferchal F; Clauvel JP; Seligmann M; Hopital Saint-Louis, Paris, France.
STUDY OBJECTIVE: To determine whether zidovudine is effective in increasing the platelet count in patients with thrombocytopenic purpura related to human immunodeficiency virus (HIV) infection. DESIGN: Nonrandomized controlled trial with two consecutive regimens. SETTING: Immunopathology and hematology clinics at two
Scaravilli F; Daniel SE; Harcourt-Webster N; Guiloff RJ; Department of Neuropathology, National Hospital, Queen Square,; London, England.
We describe the clinical and postmortem findings in a 57-year-old man with human immunodeficiency virus who presented with neurologic symptoms attributed to stroke. In addition to multiple foci of ischemic necrosis, pathologic examination of the brain showed chronic basal meningitis and vasculitis. No microorganisms w
Goethe KE; Mitchell JE; Marshall DW; Brey RL; Cahill WT; Leger GD; Hoy LJ; Boswell RN; Department of Psychology, Wilford Hall US Air Force Medical; Center, Lackland Air Force Base, Tex. 78236-5300.
Although individuals with acquired immunodeficiency syndrome (AIDS) are often impaired on a variety of neuropsychological tasks, questions remain as to when neuropsychological decline can be reliably detected during the course of human immunodeficiency virus (HIV) infection. Detailed neuropsychological testing was acc
Biochem Biophys Res Commun. 1989 Jan 31;158(2):413-22. Unique Identifier : AIDSLINE MED/89134240
Balzarini J; Cools M; De Clercq E; Rega Institute for Medical Research, Katholieke Universiteit; Leuven, Belgium.
There is a close linear correlation between the log partition coefficient (Pa) of a series of 2 -deoxyriboside (dR), 2 ,3 -didehydro-3 -dideoxyriboside (ddeR), 2 ,3 -dideoxyriboside (ddR), 3 -fluoro-2 ,3 -dideoxyriboside (FddR) and 3 -azido-2 ,3 -dideoxyriboside (AzddR) derivatives of uracil, cytosine, thymine, guanin
Merrill JE; Kagan JM; Schmid I; Strom SR; Quan SG; Chen IS; Department of Neurology, UCLA School of Medicine 90024.
Cerebrospinal fluid (CSF) lymphocytes from patients with multiple sclerosis (MS) were transformed with human T cell leukemia/lymphoma virus (HTLV I and HTLV II) and the resulting cell lines characterized by cell surface phenotyping and functional assessment. The lines were predominantly of the CD4 helper/induce phenot
Overby KJ; Lo B; Litt IF; Department of Pediatrics, Stanford University School of Medicine,; California.
The knowledge and concerns regarding acquired immunodeficiency syndrome (AIDS) and their relationship to certain behaviors among adolescents with hemophilia, a pediatric risk group with human immunodeficiency virus (HIV) antibody positivity rate as high as 70% to 90%, are described. Information was obtained from 26 pa
Am J Med. 1989 Feb;86(2):237-40. Unique Identifier : AIDSLINE MED/89116260
Murphy PM; Fox C; Travis W; Koenig S; Fauci AS; Laboratory of Clinical Investigation, National Institute of; Allergy and Infectious Diseases, Bethesda, Maryland 20892.
Indian J Med Res. 1989 Jan;89:1-3. Unique Identifier : AIDSLINE MED/89122164
John TJ; Babu PG; Pulimood BR; Jayakumari H
HIV infection was found among voluntary blood donors at the Christian Medical College Hospital, Vellore (south India ), the prevalence rate of infection among these donors being 1.63 per 1000. Based on these findings, the authors recommend that appropriate steps be taken immediately
J Immunol. 1989 Feb 15;142(4):1166-76. Unique Identifier : AIDSLINE MED/89124356
Schrier RD; Gnann JW Jr; Landes R; Lockshin C; Richman D; McCutchan A; Kennedy C; Oldstone MB; Nelson JA; Department of Immunology, Research Institute of Scripps Clinic,; La Jolla, CA 92037.
Because T cell responses are critical for defense against viral infections, a series of synthetic peptides derived from the predicted sequence for HIV-1 proteins gp41, pg120, gag, and viral polymerase were used to test the T cell proliferative response of HIV-1 seropositive individuals. Of HIV-1-infected donors from v
Jones P; Newcastle Haemophilia Centre, Royal Victoria Infirmary, U.K.
Zidovudine was first prescribed for patients from the anti-human immunodeficiency virus (HIV) positive cohort of haemophiliacs in Newcastle in May 1987. Prior to this therapy, seven patients had died of acquired immune deficiency syndrome, and episodes of serious opportunistic infection were common. To date, 22 patien
Hadzopoulou-Cladaras M; Felber BK; Cladaras C; Athanassopoulos A; Tse A; Pavlakis GN; BRI-Basic Research Program, National Cancer Institute, Frederick,; Maryland 21701-1013.
The study of expression of several human immunodeficiency virus type 1 proviral mutants in human cells in the presence or absence of rev (trs/art) protein reveals that rev increases the levels of unspliced and env mRNA and the accumulated structural viral proteins. rev protein produced from appropriate expression vect
Cann AJ; Rosenblatt JD; Wachsman W; Chen IS; Jonsson Comprehensive Cancer Center, Los Angeles, California.
The tax gene of the human T-cell leukemia virus types I and II (HTLV-I and HTLV-II) is essential for viral replication and acts by increasing the level of RNA transcription. The tax genes of HTLV-I and HTLV-II encode proteins of 40 and 37 kilodaltons, respectively. By in vitro mutagenesis of the tax gene, we have inve
JAMA. 1989 Mar 3;261(9):1306-9. Unique Identifier : AIDSLINE MED/89125858
Koonin LM; Ellerbrock TV; Atrash HK; Rogers MF; Smith JC; Hogue CJ; Harris MA; Chavkin W; Parker AL; Halpin GJ; Division of Reproductive Health, Center for Chronic Disease; Prevention and Health Promotion, Atlanta, GA 30333.
From 1981 to 1988, eighty percent of all women with the acquired immunodeficiency syndrome (AIDS) reported to the Centers for Disease Control were of reproductive age. Six pregnancy-associated deaths due to AIDS in this country have been reported in the medical literature. We identified 20 unpublished cases of women w
Lang JM; Coumaros G; Levy S; Falkenrodt A; Steckmeyer M; Partisani M; Aleksijevic A; Lehr L; Koehl C; Service d'Onco-Hematologie, Hopital de Hautepierre, Strasbourg,; France.
Serum levels of soluble interleukin-2 receptors (sIL-2R) were measured in 105 HIV-seropositive individuals simultaneously with T cell subsets and activated T cells (CD3+ and HLA-DR+). Significantly elevated levels of serum sIL-2R were found (564 +/- 259 U/ml versus 258 +/- 87 U/ml in 70 controls, p less than 0.001), a
Fineman DS; Palestro CJ; Kim CK; Needle LB; Vallabhajosula S; Solomon RW; Goldsmith SJ; Department of Nuclear Medicine, Mount Sinai Medical Center, New; York, NY 10029.
Thirty-six patients with acquired immunodeficiency syndrome (AIDS), who were febrile but without localizing signs, underwent indium-111 leukocyte scintigraphy 24 hours after injection of labeled white blood cells (WBCs) and were restudied 48 hours after injection of gallium-67 citrate. Fifty-six abnormalities were ide
Am J Gastroenterol. 1989 Feb;84(2):207-9. Unique Identifier : AIDSLINE MED/89132518
Romeu J; Clotet B; Tural C; Carles J; Foz M; Department of Internal Medicine, Universitat Autonoma de; Barcelona, Hospital de Badalona Germans Trias i Pujol, Spain.
Fogorv Sz. 1989 Jan;82(1):19-22. Unique Identifier : AIDSLINE MED/89107616
Bori Z; Ferenczi I; Lajta B
The endangerment caused by the blood contents of spray formed in the course of oonserving and prosthetical work of dentists performed by dental drill was examined. It was found that the protective mask in case of grinding and drilling the front teeth becomes always while in case of treating the molars less frequently
Shen RN; Hornback NB; Lu L; Chen LT; Brahmi Z; Broxmeyer HE; Department of Radiation Oncology, Indiana University School of; Medicine, Indianapolis 46223.
Immunosuppression characterizes many human diseases including leukemia and AIDS. Friend virus (FV)-induced murine leukemia is a useful model for studying both malignancy and immunosuppression. In a previous series of experiments, we have demonstrated that untreated FV-infected mice died within 40 days post-infection,
Winton GB; Department of Medicine, Walter Reed Army Medical Center,; Washington, DC 20307-5001.
During pregnancy, immunologic, endocrine, metabolic, and vascular changes occur that make the pregnant woman susceptible to aggravation of certain skin diseases. These diseases can be organized into five broad categories: infections, diseases of altered immunity, metabolic diseases, connective tissue disorders, and mi
Hannon WH; Lewis DS; Jones WK; Powell MK; Division of Environmental Health Laboratory Sciences, Centers for; Disease Control, Atlanta, GA 30333.
Epidemiologic projects have been implemented for using dried-blood spot (DBS) specimens routinely collected on filter paper from neonates as a seroepidemiologic resource to monitor seroprevalence of human immunodeficiency virus (HIV) among childbearing women. To ensure the quality of the data base produced from the na
Leport C; Rousseau F; Perronne C; Salmon D; Joerg A; Vilde JL; Department of Infectious and Tropical Diseases, Claude Bernard; Hospital, Paris, France.
Bacterial prostatitis was diagnosed in 17 of 209 human immunodeficiency virus-infected men hospitalized from October 1985 to October 1987. A history of urogenital disease was found in 13 of 17 patients. Clinical signs of prostatitis were present in 16 of 17 patients, including fever in 13, urinary symptoms in 11 and t
Orv Hetil. 1989 Jan 8;130(2):67-70. Unique Identifier : AIDSLINE MED/89112737
Ujhelyi E; Gal G; Mako J; Fust G; Buki B; Nagy K; Ferenc DT; Dietrich MP; Hengster P; Mayer V; et al
The sera of 173 haemodialysis patients treated in two dialysis centers in Hungary were tested for the presence of HIV (HTLV III/LAV) antibodies. Four different commercial enzyme immunoassay (EIA) kits and two types (CEM/LAV, and H9/
STUDY OBJECTIVE: To define the pharmacokinetics of zidovudine (azidothymidine) in children with human immunodeficiency virus infection. DESIGN: Plasma, urine, and cerebrospinal fluid were obtained following a single 80 mg/m2 body surface dose infused over 1 hour (n = 9), and during a continuous infusion of 0.5 (n = 3)
AORN J. 1989 Jan;49(1):276-83. Unique Identifier : AIDSLINE MED/89117128
Trotti JC; McCarthy RT; Brooke Army Medical Center, San Antonio, Tex.
The area of research and prevention of occupational health hazards that affect operating room nurses has not been formalized. There are many devices and substances that present actual and potential dangers to OR nurses. Historically, more attention has been paid to the effect of these substances and equipment on the p
Rico MJ; Hall RP 3d; Department of Medicine, Duke University Medical Center, Durham,; NC 27710.
Antibodies specific for determinants within the variable region of an antibody molecule are known as anti-idiotypic antibodies. Anti-idiotypic antibodies specific for determinants within the antigen binding site of the antibody may mimic the original antigen and are said to bear an internal image of the antigen. These
Chonmaitree T; Baldwin CD; Lucia HL; Department of Pediatrics, University of Texas Medical Branch,; Galveston 77550.
A number of viruses cause acute central nervous system disease. The two major clinical presentations are aseptic meningitis and the less common meningoencephalitis. Clinical virology laboratories are now more widely available than a decade ago; they can be operated on a modest scale and can be tailored to the needs of
Hosp Community Psychiatry. 1989 Feb;40(2):146-53. Unique Identifier : AIDSLINE MED/89121917
Fernandez F; Holmes VF; Levy JK; Ruiz P; Baylor College of Medicine, Houston, Texas.
Acquired immune deficiency syndrome (AIDS) and related disorders are increasingly and unsettlingly prevalent. The authors describe neuropsychiatric, psychosocial, and ethical-legal problems associated with HIV infections that are commonly encountered in a consultation-liaison psychiatry setting. Because of HIV s poten
McKeever BM; Navia MA; Fitzgerald PM; Springer JP; Leu CT; Heimbach JC; Herbert WK; Sigal IS; Darke PL; Department of Biophysical Chemistry, Merck Sharp and Dohme; Research Laboratories, Rahway, New Jersey 07065.
The aspartylprotease of the human immunodeficiency virus HIV-1 (NY5) has been crystallized in a form suitable for x-ray diffraction analysis. The crystals are tetragonal bipyramids and produce an x-ray diffraction pattern that exhibits the symmetry associated with space group P4(1)2(1)2 (or its enantiomorph, P4(3)2(1)
Darke PL; Leu CT; Davis LJ; Heimbach JC; Diehl RE; Hill WS; Dixon RA; Sigal IS; Department of Molecular Biology, Merck, Sharp and Dohme Research; Laboratories, West Point, Pennsylvania 19486.
The protease of human immunodeficiency virus has been expressed in Escherichia coli and purified to apparent homogeneity. Immunoreactivity toward anti-protease peptide sera copurified with an activity that cleaved the structural polyprotein gag p55 and the peptide corresponding to the sequence gag 128-135. The enzyme
Horn R; Laszlo A; Robson HG; Department of Clinical Microbiology, Royal Victoria Hospital,; Montreal, Quebec, Canada.
We describe a simple technique for recovery of Mycobacterium avium-M. intracellulare from blood culture specimens by using the BACTEC 460, a system used for routine blood cultures in many hospital laboratories. A total of 26 of 215 blood specimens (12%) from 11 of 48 patients (23%) with acquired immunodeficiency syndr
Simor AE; Poon R; Borczyk A; Department of Microbiology, Mount Sinai Hospital, Toronto,; Ontario, Canada.
Shigella sp. is known to be an important cause of diarrhea in homosexual men, although chronic infection is infrequently recognized. We describe recurrent and relapsing symptomatic infection due to Shigella flexneri in a human immunodeficiency virus-infected homosexual man subsequently developed acquired immunodeficie
Yeo JM; Wellcome Research Laboratories, Beckenham, U.K.
The first placebo-controlled trial of zidovudine in the management of HIV infection involved patients with the acquired immune deficiency syndrome (AIDS) following their first episode of Pneumocystis carinii pneumonia and patients with severe AIDS-related complex (ARC). Zidovudine was shown to increase survival, and t
Merigan TC; Department of Medicine, Stanford University School of Medicine,; California 94305.
This presentation summarizes the US national cooperative trials for AIDS treatment and some specific efforts in the treatment of viral infections. The underlying principles behind clinical efforts in the control of the human immunodeficiency virus are described to date. In addition, concerns are voiced regarding the o
Silvestris F; Gernone A; Frassanito MA; Dammacco F; Istituto di Patologia Medica, University of Bari School of; Medicine, Italy.
The immunologic effects of a year-long therapeutic trial with the synthetic thymic hormone thymopentin were investigated in 29 patients with human immunodeficiency virus--induced lymphadenopathy syndrome. Peripheral T4 and T8 lymphocyte subsets and in vitro immunoglobulin synthesis with pokeweed mitogen (PWM) were mon
Boers M; Peeters AJ; van Berkel M; de Graaf P; van der Meer JW
This report describes the fatal outcome of an infection with Shigella flexneri in a 39-yr-old man with the acquired immunodeficiency syndrome (AIDS). The pertinent literature is reviewed.
Proc Natl Acad Sci U S A. 1989 Feb;86(3):755-64. Unique Identifier : AIDSLINE MED/89128857
Duesberg PH; Department of Molecular Biology, University of California,; Berkeley 94720.
AIDS is an acquired immunodeficiency syndrome defined by a severe depletion of T cells and over 20 conventional degenerative and neoplastic diseases. In the U.S. and Europe, AIDS correlates to 95% with risk factors, such as about 8 years of promiscuous male homosexuality, intravenous drug use, or hemophilia. Since AID
Proc Natl Acad Sci U S A. 1989 Feb;86(3):807-11. Unique Identifier : AIDSLINE MED/89128866
Krausslich HG; Ingraham RH; Skoog MT; Wimmer E; Pallai PV; Carter CA; Department of Microbiology, State University of New York, Stony; Brook 11794.
Retroviral capsid proteins and replication enzymes are synthesized as polyproteins that are proteolytically processed to the mature products by a virus-encoded proteinase. We have purified the proteinase of human immunodeficiency virus (HIV), expressed in Escherichia coli, to approximately 90% purity. The purified enz
Sligh JM; Roodman ST; Tsai CC; Department of Pathology, St. Louis University School of Medicine,; Missouri 63104.
A flow cytometric immunofluorescence assay (FIFA) was developed to detect antibodies to human immunodeficiency virus (HIV) using live cell indirect immunofluorescence and analysis by flow cytometry. A panel of 107 sera, previously tested for anti-HIV antibody with the Abbott Enzyme-Linked Immunosorbent Assay test and
Acquired immunodeficiency syndrome (AIDS) is a multisystem disorder characterized by defects in the immune system that result in opportunistic infections and neoplasms. While endocrine dysfunction has not been a prominent clinical feature of AIDS, all endocrine glands may be affected by the opportunistic infections an
Reddy MM; Lange M; Grieco MH; R. A. Cooke Institute of Allergy, St. Luke's-Roosevelt Hospital; Center, New York, New York 10019.
Soluble CD8 levels in sera were quantitated in asymptomatic intravenous drug abusers, homosexuals, and patients with lymphadenopathy or acquired immunodeficiency syndrome. Soluble CD8 levels were elevated in human immunodeficiency virus-seronegative intravenous drug abusers and homosexuals, probably reflecting infecti
Zidovudine was used in an open uncontrolled study for treatment of 145 human immunodeficiency virus (HIV) patients, 102 with acquired immune deficiency syndrome (AIDS) and 43 with symptomatic HIV disease (acquired immune deficiency syndrome related-complex, ARC). The mean period of follow-up was 6 +/- 2.5 months. The
Lange JM; de Wolf F; Mulder JW; Coutinho RA; van der Noordaa J; Goudsmit J; Department of Virology, University of Amsterdam, The Netherlands.
Eighteen asymptomatic men with persistent human immunodeficiency virus type I (HIV-I) p24 antigenaemia were treated with zidovudine 250-500 mg (+/- acyclovir 800 mg) 6-hourly for 4-12 weeks, and subsequently with zidovudine 500 mg (+/- acyclovir 1600 mg) 12-hourly for 36 weeks.
Mace K; Duc Dodon M; Gazzolo L; Laboratoire d'Immuno-Virologie Moleculaire et Cellulaire, UMR; 0005 du CNRS, Faculte de Medecine Alexis Carrel, Lyon, France.
A comparative study of the replication kinetics of human immunodeficiency virus type 1 (HIV-1) was performed in the promonocytic U937 cells and in the T lymphoblastoid H9 cells. If a productive HIV-1 infection of both cell types could be established, the time which elapses before most of the cells could express viral
Am J Hematol. 1989 Mar;30(3):128-39. Unique Identifier : AIDSLINE MED/89132547
Ehrlich GD; Davey FR; Kirshner JJ; Sninsky JJ; Kwok S; Slamon DJ; Kalish R; Poiesz BJ; Department of Medicine, State University of New York Health; Science Center, Syracuse 13210.
HTLV-I is associated with adult T-cell leukemia/lymphoma (ATL) characterized by monoclonal expansions of CD4+ T-lymphocytes. In this report we describe a histologically benign, polyclonal HTLV-I infection in a patient exhibiting both an absolute CD4+ and CD8+ lymphocytosis. Three T-cell lines containing integrated HTL
J Immunol. 1989 Feb 1;142(3):773-80. Unique Identifier : AIDSLINE MED/89110048
Gowda SD; Stein BS; Mohagheghpour N; Benike CJ; Engleman EG; Department of Pathology, Stanford University School of Medicine,; CA 94305.
The relationship of T cell activation to HIV entry and generation of viral DNA intermediates was studied in freshly isolated CD4+ T lymphocytes. Unstimulated cells exposed to infectious virus for up to 48 h did not synthesize any detectable unintegrated HIV DNA duplex forms or integrated genomic provirus. However, act
Pinching AJ; Helbert M; Peddle B; Robinson D; Janes K; Gor D; Jeffries DJ; Stoneham C; Mitchell D; Kocsis AE; et al; Department of Immunology and Medicine, St Mary's Hospital and; Medical School, London, U.K.
We have treated 113 patients with zidovudine since its licensure, 80 with acquired immunodeficiency syndrome and 33 with acquired immunodeficiency syndrome-related complex. This paper reports on the efficacy and toxicity observed in these patients. Improved well-being, reduced frequency and severity of opportunist inf
Cell. 1989 Jan 27;56(2):303-12. Unique Identifier : AIDSLINE MED/89106222
Edery I; Petryshyn R; Sonenberg N; Department of Biochemistry, McGill University, Montreal, Quebec,; Canada.
All mRNAs of human immunodeficiency virus 1 (HIV-1) contain in their 5 untranslated region a sequence termed TAR that responds to trans-activation by the tat (trans-activating) protein. This RNA sequence assumes a stable secondary structure, and its cap structure is relatively inaccessible. Here we report that these
J Med Chem. 1989 Feb;32(2):461-6. Unique Identifier : AIDSLINE MED/89110935
Mansuri MM; Starrett JE Jr; Ghazzouli I; Hitchcock MJ; Sterzycki RZ; Brankovan V; Lin TS; August EM; Prusoff WH; Sommadossi JP; et al; Bristol-Myers Pharmaceutical Research and Development Division,; Wallingford, Connecticut 06492-7660.
The nucleoside analogue 1-(2,3-dideoxy-beta-D-glycero-pent-2-enofuranosyl)thymine ( d4T , 1) was prepared by ring opening of the 3 ,5 -anhydro compound 5. This method has been refined such that it can be used to prepare d4T on a large scale. The triphos
Ann Intern Med. 1989 Feb 15;110(4):297-303. Unique Identifier : AIDSLINE MED/89116733
Weisbart RH; Gasson JC; Golde DW; Department of Medicine, UCLA School of Medicine.
Colony-stimulating factors are growth factors responsible for the proliferation and the maturation of bone marrow stem cells to fully differentiated granulocytes and monocytes. In addition to their effects on hematopoiesis, some colony-stimulating factors prime mature cells for enhanced chemotaxis, phagocytosis, and k
Rostad SW; Olson K; McDougall J; Shaw CM; Alvord EC Jr; Department of Pathology, University of Washington School of; Medicine, Seattle 98195.
We report a patient with pathologic evidence of anterograde spread of varicella zoster virus (VZV) through the visual system. A 29-year-old homosexual man developed the acquired immunodeficiency syndrome (AIDS) 2 months before the onset of left herpes zoster ophthalmicus. During the next 11 months, the zoster infectio
Brack-Werner R; Barton DE; Werner T; Foellmer BE; Leib-Mosch C; Francke U; Erfle V; Hehlmann R; Abt. fur Molekulare Zellpathologie, Gesellschaft fur; Strahlen-und Umweltforschung, Neuherberg, Federal Republic of; Germany.
A new family of human endogenous retroviral sequences was recently discovered by way of its relationship to the simian sarcoma-associated virus (SSAV). One molecular clone, termed S71, contains sequences related to the genes coding for the group-specific antigens (gag) and polymerase (pol) proteins of SSAV. At the 3
Maekawa T; Itoh F; Okamoto T; Kurimoto M; Imamoto F; Ishii S; Tsukuba Life Science Center, Institute of Physical and Chemical; Research (RIKEN), Ibaraki, Japan.
The enhancer-binding factor of human immunodeficiency virus (HIV)-1 was purified from human B cells by sequence-specific duplex oligonucleotide affinity chromatography. Gel retardation assay and footprint analysis showed that the purified factor bound specifically to the HIV-1 enhancer sequence, and protected both dir
Ng VL; York M; Hadley WK; Department of Laboratory Medicine, University of California, San; Francisco.
We isolated Bordetella pertussis from three patients with acquired immunodeficiency syndrome who underwent diagnostic bronchoscopy for evaluation of respiratory symptoms. The B. pertussis isolates were recovered from medium (charcoal-yeast extract agar) formulated to enhance recovery of Legionella spp., and one of the
J Immunol. 1989 Feb 15;142(4):1177-82. Unique Identifier : AIDSLINE MED/89124357
Tyler DS; Nastala CL; Stanley SD; Matthews TJ; Lyerly HK; Bolognesi DP; Weinhold KJ; Department of Surgery, Duke University Medical Center, Durham, NC; 27710.
Fresh circulating PBMC from HIV-1 seropositive individuals have been found to mediate specific, non-MHC restricted lysis of targets expressing the major envelope glycoprotein of HIV-1, gp120, in 6-h 51Cr release assays. This gp120 specific cell-mediated cytotoxicity (CMC) is broadly reactive against target cells infec
Ong EL; Ellis ME; Tweedle DE; Ferguson G; Haboubi NY; Knox WF; Monsall Hospital, Regional Department of Infectious Diseases and; Tropical Medicine, Manchester, U.K.
Cytomegalovirus ( CMV ) is an important cause of acalculous gangrenous cholecystitis in immunocompromised persons. We report a case of acalculous acute cholecystitis and active colitis associated with CMV in a patient suffering from the acquired immune deficiency
Rahman MA; Kingsley LA; Breinig MK; Ho M; Armstrong JA; Atchison RW; Lyter DW; Rinaldo CR Jr; Department of Epidemiology, University of Pittsburgh, Graduate; School of Public Health, Pennsylvania 15261.
We investigated the association between human immunodeficiency virus (HIV) and Epstein-Barr virus (EBV) infections in 593 homosexual men. The status of EBV infection in this group was evaluated based on serological evidence of EBV-specific antibody responses. The geometric mean titers (GMT) of antibody to EBV capsid a
Peterson PK; Gekker G; Brummitt C; Pentel P; Bullock M; Simpson M; Hitt J; Sharp B; Department of Medicine, Hennepin County Medical Center,; Minneapolis, Minnesota 55415.
Recent studies have shown that in vitro exposure of peripheral blood mononuclear cells (PBMC) to morphine results in suppressed respiratory-burst activity of monocytes and impaired interferon-gamma (IFN-gamma) production by lymphocytes. To investigate the potential in vivo effect of an opiate on these cell functions,
Hauber J; Malim MH; Cullen BR; Howard Hughes Medical Institute, Duke University Medical Center,; Durham, North Carolina 27710.
The tat trans-activators encoded by the known strains of primate immunodeficiency virus share a conserved, highly basic protein domain. Mutagenesis of this sequence in the tat gene of human immunodeficiency virus type 1 is shown here to reduce, but not eliminate, the trans-activation of human immunodeficiency virus ty
Hartley JW; Fredrickson TN; Yetter RA; Makino M; Morse HC 3d; Laboratory of Immunopathology, National Institute of Allergy and; Infectious Diseases, Bethesda, Maryland 20892.
C57BL mice (Fv-1b) develop a severe immunodeficiency disease following inoculation as adults with LP-BM5 murine leukemia virus (MuLV), a derivative of Duplan-Laterjet virus which contains B-tropic ecotropic and mink cell focus-inducing MuLVs and a putative defective genome which may be the proximal cause of disease. T
Life Sci. 1989;44(3):iii-xv. Unique Identifier : AIDSLINE MED/89126797
Watson RR; Department of Family and Community Medicine, Arizona Health; Sciences Center, University of Arizona, Tucson 85724.
The mouse has been suggested as a host for comparative studies of several aspects of Human Acquired Immune Deficiency Syndrome (AIDS). Models include studies where part or all of the genome of Human Immunodeficiency Virus (HIV) has been incorporated into murine DNA in living mice. However, the most promising opportuni
Nature. 1989 Feb 9;337(6207):525-31. Unique Identifier : AIDSLINE MED/89127515
Capon DJ; Chamow SM; Mordenti J; Marsters SA; Gregory T; Mitsuya H; Byrn RA; Lucas C; Wurm FM; Groopman JE; et al; Department of Molecular Biology, Genentech, Inc., South San; Francisco, California 94080.
A newly-constructed antibody-like molecule containing the gp120-binding domain of the receptor for human immunodeficiency virus blocks HIV-1 infection of T cells and monocytes. Its long plasma half-life, other antibody-like properties, and potential to block all HIV isolates, make it a good candidate for therapeutic u
Nature. 1989 Feb 9;337(6207):576-9. Unique Identifier : AIDSLINE MED/89127525
Miller M; Jaskolski M; Rao JK; Leis J; Wlodawer A; Crystallography Laboratory, NCI-Frederick Cancer Research; Facility, Maryland 21701.
Retroviral gag, pol and env gene products are translated as precursor polyproteins, which are cleaved by virus-encoded proteases to produce the mature proteins found in virions. On the basis of the conserved Asp-Thr/Ser-Gly sequence at the putative protease active sites, and other biochemical evidence, retroviral prot
Clark L; Hay RT; Department of Biochemistry and Microbiology, University of St; Andrews, Fife, UK.
Short DNA sequence motifs have been identified in viral and cellular enhancers which represent the binding sites for a variety of trans- acting factors. One such HeLa cell factor, EBP1, has been purified and shown to bind to sequences in the SV40 enhancer. The PRDII element in the human beta-interferon gene regulatory
Proc Natl Acad Sci U S A. 1989 Feb;86(3):821-4. Unique Identifier : AIDSLINE MED/89128869
Gentz R; Chen CH; Rosen CA; Department of Molecular Oncology, Roche Research Center, Nutley,; NJ 07110.
Expression of the human immunodeficiency virus tat-encoded protein (Tat) is required for virus replication. A genetic approach was used to facilitate the purification of biologically active Tat. A recombinant Tat protein containing a stretch of six histidine residues and a protease cleavage site was engineered and pur
Kramer EL; Sanger JH; Garay SM; Grossman RJ; Tiu S; Banner H; Division of Nuclear Medicine, NYU Medical Center, NY 10016.
Consecutive gallium-67 scans (n = 237) of 180 human immunodeficiency virus-seropositive patients with suspected pulmonary infections were evaluated for intensity and pattern of gallium distribution. Scan findings were correlated with the history, chest radiographic findings, and clinicopathologic diagnoses. Pneumocyst
Schmader KE; van der Horst CM; Klotman ME; Department of Medicine, Duke University Medical Center, Durham,; North Carolina 27710.
The ability of the Epstein-Barr virus (EBV) to cause latent lifelong infection in the host and its capabilities of transformation may have important implications for the elderly host. Reports in the literature and hospital records were reviewed to determine the activity of EBV in the elderly. Seroepidemiologic surveys
Henry MJ; Stanley MW; Cruikshank S; Carson L; Department of Pathology, Hennepin County Medical Center,; Minneapolis, MN 55415.
Human papillomavirus infection plays an important causal role in cervical intraepithelial neoplasia and carcinoma. The rate of infection with human papillomavirus as well as the incidence of cervical intraepithelial neoplasia and carcinoma are increased in immunosuppressed patients. We report a possible association be
Am J Pathol. 1989 Feb;134(2):373-83. Unique Identifier : AIDSLINE MED/89132749
Ringler DJ; Wyand MS; Walsh DG; MacKey JJ; Chalifoux LV; Popovic M; Minassian AA; Sehgal PK; Daniel MD; Desrosiers RC; et al; Harvard Medical School, New England Regional Primate Research; Center, Southborough, MA 01772.
Simian immunodeficiency virus (SIV) is a lentivirus with genetic relatedness to the human immunodeficiency viruses (HIV-1 and HIV-2). It induces a fatal syndrome in rhesus monkeys that closely parallels the clinical course of AIDS in humans. The authors used double-labeling immunohistochemical procedures on rhesus lym
Am J Pathol. 1989 Feb;134(2):385-93. Unique Identifier : AIDSLINE MED/89132750
Wyand MS; Ringler DJ; Naidu YM; Mattmuller M; Chalifoux LV; Sehgal PK; Daniel MD; Desrosiers RC; King NW; Harvard Medical School, New England Regional Primate Research; Center, Southborough, MA 01772.
Lymph nodes and spleens were collected at autopsy and by biopsy from 29 rhesus monkeys infected with simian immunodeficiency virus (SIV). Lymph nodes were classified morphologically into stages of follicular hyperplasia, follicular involution, follicular depletion with normal or expanded paracortices, follicular and p
Fowler CB; Reed KD; Brannon RB; Department of Oral Pathology, Wilford Hall, Lackland AFB, TX; 78236-5300.
Hairy leukoplakia (HL) is an Epstein-Barr virus-associated lesion of the oral mucosa that occurs in persons infected with human immunodeficiency virus. Ultrastructural studies have demonstrated herpes-type virions in 63-100% of cases of HL. In this investigation, incisional biopsy specimens from 52 consecutive patient
Lunardi-Iskandar Y; Nugeyre MT; Georgoulias V; Barre-Sinoussi F; Jasmin C; Chermann JC; Unite d'Oncogenese Appliquee (Institut Nationale de la Sante; et de la Recherche Medicale), Hopital Paul Brousse, Villejuif,; France.
HIV-1 infection in vitro of normal bone marrow mononuclear cells (BMMC) depleted of mature T cells was studied. BMMC depleted of either CD3, CD2, or both could replicate HIV-1 irrespective of the presence of macrophages/monocytes. Infected bone marrow cells were shown to differentiate during the culture into CD3+, CD4
J Immunol. 1989 Feb 1;142(3):971-8. Unique Identifier : AIDSLINE MED/89110079
Palker TJ; Tanner ME; Scearce RM; Streilein RD; Clark ME; Haynes BF; Department of Medicine, Duke University Medical Center, Durham,; NC 27710.
Antigenic sites on human T cell leukemia virus type I (HTLV-I) gp46 and gp21 envelope glycoproteins that are immunogenic in man were studied with envelope gene (env)-encoded synthetic peptides and a mAb to HTLV-I gp46 envelope glycoprotein. Antibodies in 78% of sera from HTLV-I seropositive subjects reacted with synth
Lancet. 1989 Feb 11;1(8633):309-11. Unique Identifier : AIDSLINE MED/89126668
Lantos PL; McLaughlin JE; Schoitz CL; Berry CL; Tighe JR; Department of Neuropathology, Institute of Psychiatry, London.
The brains of 26 patients infected with the human immunodeficiency virus (HIV) were examined post mortem. All patients were men, aged 20-67 years (mean 38.8). 13 (50%) were homosexual, 3 (12%) were bisexual, 8 (31%) were haemophiliac, 1 was both an intravenous drug addict and homosexual, and 1 denied belonging to any
Marcusson JA; Wetterberg L; Department of Dermatology, Huddinge Hospital, Sweden.
The following is a description of the improvement of a HIV-negative patient with psoriasis and monoarthritis who received treatment with Peptide-T, a synthetic octapeptide that shares a segment of the envelope glycoprotein (gp 120) of the human immunodeficiency virus.
Kusk P; Ulrich K; Zeuthen J; Pallesen G; Laboratory of Tumor Virology, Fibiger Institute, Danish Cancer; Society, Copenhagen.
Eight different monoclonal antibodies (MAbs) were raised against a lysate of the HTLV-IIIb isolate of human immunodeficiency virus (HIV). All eight MAbs recognized the major core protein p24 as well as the gag precursors p39 and p55. Three different epitopes were defined by the eight MAbs when an antigen-catching ELIS
AIDS Res Hum Retroviruses. 1988 Dec;4(6):409-17. Unique Identifier : AIDSLINE MED/89118010
Koito A; Hattori T; Matsushita S; Maeda Y; Nozaki C; Sagawa K; Takatsuki K; Second Department of Internal Medicine, Kumamoto University; Medical School, Japan.
A murine monoclonal antibody (MoAb), VAK 4, has been known to specifically react with a major core protein (p24) as well as with its precursor (p55-57) and intermediate precursor (p40) of human immunodeficiency virus strain IIIB (HTLV-IIIB). Radioimmunoprecipitation assays revealed that VAK 4 MoAb precipitated a major
AIDS Res Hum Retroviruses. 1988 Dec;4(6):441-8. Unique Identifier : AIDSLINE MED/89118013
Schwartz O; Henin Y; Marechal V; Montagnier L; Unite d'Oncologie Virale, Institut Pasteur, Paris, France.
We report here the use of a simple, rapid, reproducible, and quantitative assay to detect the putative activity of anti-HIV agents. It can be employed with different T cell cultures, such as peripheral blood lymphocytes or CEM-C113 cells, a sensitive clone of CEM cells. It can be used alone as a rapid screening test i
Gene. 1988 Aug 15;68(1):35-42. Unique Identifier : AIDSLINE MED/89121492
Leuthardt A; Le Grice SF; Central Research Units, F. Hoffmann-La Roche & Co. Ltd., Basel,; Switzerland.
Elimination of the protease domain from the polymerase open reading frame (pol) of the human immunodeficiency virus type 1 (HIV-1) leads, in Escherichia coli, to synthesis and accumulation of a non-processed 98-kDa reverse transcriptase/endonuclease (RT/ENDO) polyprotein. A partially purified preparation of this rever
Bost KL; Hahn BH; Saag MS; Shaw GM; Weigent DA; Blalock JE; Department of Physiology and Biophysics, UAB 35294.
Studies are presented here which demonstrate that antibodies reacting with human interleukin-2 ( IL-2 ) are present in the sera of patients infected with the human immunodeficiency virus (HIV). It is likely that these antibodies are present due to a homology between the
Stuart JD; Kenney JG; Lettieri J; Spotnitz W; Baker J; Department of Plastic Surgery, University of Virginia,; Charlottesville.
Early tangential excision and immediate grafting of the burn-injured patient has been shown to be effective. Along with the use of this technique, however, comes the potential for significant blood loss, prolonged operative time, and partial loss of graft due to underlying hematoma formation. Based on experience using
A novel immunoassay technique using synthetic lipopeptide (Pam3Cys-Ser) linked to immunodominant peptide domains of HIV-1 and HIV-2 envelope proteins as an antigen adsorbent has been developed. Attachment of peptides to microtiter plates can be considerably improved with this method by employing the hydrophobic proper
Kiernan RE; McPhee DA; Doherty RR; NHMRC Special Unit for AIDS Virology, Macfarlane Burnet Centre; for Medical Research, Fairfield Hospital, Victoria, Australia.
This report describes a modified plaque forming assay which has been used for quantitation of infectious human immunodeficiency virus (HIV) in cell culture supernatant fluid. The number of infectious units determined by the plaque assay correlates closely with the 50% infectious dose determined by a conventional assay
J Immunol. 1989 Feb 15;142(4):1144-9. Unique Identifier : AIDSLINE MED/89124353
Klinman DM; Morse HC 3d; Infectious Diseases Branch, National Institute of Neurological; and Communicative Disorders and Stroke, Bethesda, MD 20892.
A syndrome characterized by lymphadenopathy, hypergammaglobulinemia, and immunodeficiency develops in C57BL/6 mice inoculated with LP-BM5 murine leukemia viruses. By studying the number and antigenic specificity of B cells activated in the course of this disease, we found that a series of reproducible changes in the h
Jeffries DJ; Department of Virology, St Mary's Hospital Medical School,; Paddington, London, U.K.
The development of potent anti-retroviral drugs is central to the control of human immunodeficiency virus (HIV) infection and the prevention of disease. Despite the benefit (albeit limited) shown by the early trials of zidovudine in patients with acquired immune deficiency syndrome (AIDS), there is general agreement t
Borzy MS; Connell RS; Kiessling AA; Department of Pediatrics, Doernbecher Memorial Hospital for; Children, Portland, Oregon.
Human immunodeficiency virus (HIV) was detected by assay of reverse transcriptase activity in a virus pellet obtained by differential sucrose density centrifugation of cell-free semen from three patients with the acquired immune deficiency syndrome (AIDS), one individual with AIDS-related complex (ARC), and in an asym
A monoclonal antibody recognizing an antigenic determinant on the env transmembrane protein, gp32 of simian immunodeficiency virus SIVMAC has been developed and designated SF8/5E11. The reactivity of this antibody was found to be type specific, since it did not cross-react with either SIVSMM or SIVMNe transmembrane pr
Gowda SD; Stein BS; Steimer KS; Engleman EG; Department of Pathology, Stanford University School of Medicine,; California 94305.
Human cells infected with a recombinant vaccinia virus containing human immunodeficiency virus type 1 gag-pol genes produced large amounts of human immunodeficiency virus gag proteins beginning at 1 h and peaking at 48 h postinfection. We show that these polyproteins are processed accurately into mature forms and that
Rousou J; Levitsky S; Gonzalez-Lavin L; Cosgrove D; Magilligan D; Weldon C; Hiebert C; Hess P; Joyce L; Bergsland J; et al; University of Illinois, Department of Surgery, Chicago 60680.
A multicenter study was conducted to test the efficacy and safety of fibrin sealant as a topical hemostatic agent in patients undergoing either reoperative cardiac surgery (redo) or emergency resternotomy. A total of 333 patients from 11 centers in the United States were included in th
Yokoyama S; University of Illinois, Urbana-Champaign 61820.
Molecular evolution and phylogeny of different human immunodeficiency virus type 1 (HIV1) strains, of a type 2 (HIV2) strain, and of two simian immunodeficiency viruses (SIVAGM and SIVMAC) have been studied by comparing the nucleotide sequences of the two regions of their pol genes which encode the reverse transcripta
Tersmette M; van Dongen JJ; Clapham PR; de Goede RE; Wolvers-Tettero IL; Geurts van Kessel A; Huisman JG; Weiss RA; Miedema F; Central Laboratory of the Netherlands Red Cross Blood Transfusion; Service, Amsterdam, The Netherlands.
Human immunodeficiency virus (HIV) infection was studied by means of CD4-expressing human-murine T-cell hybrids, containing a variable amount of human chromosomes. Fusion of the HPRT- murine cell line BW5147 with human T-cell acute lymphoblastic leukemia or normal human blood cells resulted in a panel of human-murine
Doi S; Nasu K; Arita Y; Tanabe S; Matsuyama F; Kamesaki H; Fukuhara S; Nishikori M; Miwa H; Kita K; et al; First Department of Internal Medicine, Kyoto University, Japan.
The authors immunohistochemically analyzed the phenotype of 40 cases of peripheral T-cell lymphoma, including 12 adult T-cell leukemia/lymphoma (ATL) cases. Molecular genetic analysis of the T-cell receptor beta-chain and immunoglobulin heavy chain genes were also applied to cases of angioimmunoblastic lymphadenopathy
Am J Public Health. 1989 Mar;79(3):287-90. Unique Identifier : AIDSLINE MED/89132886
Worden JK; Flynn BS; Merrill DG; Waller JA; Haugh LD; Office of Health Promotion Research, University of Vermont,; Burlington 05405.
A community education program was designed to train the individual drinker to self-regulate his or her blood-alcohol concentration (BAC) below a level of impairment (.05 g/dl or 11 mmol/L). Drink calculators (cardboard wheels and wallet cards) were disseminated to customers of bars and licensed beverage outlets; barte
Ann Intern Med. 1989 Mar 1;110(5):373-85. Unique Identifier : AIDSLINE MED/89133269
Fauci AS; Gallo RC; Koenig S; Salk J; Purcell RH; National Institute of Allergy and Infectious Diseases, National; Institutes of Health, Bethesda, MD 20892.
The development of a safe and effective vaccine for infection with human immunodeficiency virus (HIV) is complicated by several unique scientific, logistic, and ethical issues. These issues include a lack of understanding of protective immunity to HIV and disease development, the absence of an adequate and convenient
South Western Reporter, 2d Series. 1988 Feb 11 (date of decision);745:557-563. Unique Identifier : AIDSLINE KIE/26992
A court order directing a blood center to make available to the plaintiff in a wrongful death action certain documents identifying blood donors was upheld by the Court of Appeals of Texas. The court reasoned that the blood center could not assert a privacy interest equal to the plaintiff s right to discover the ident
New York Supplement, 2d Series. 1988 Jun 16 (date of decision);531:456-464. Unique Identifier : AIDSLINE KIE/27125
The Supreme Court of New York held that a regulation that prohibited requiring or considering body fluid tests for evidence of the human immunodeficiency syndrome (HIV) in the application for health insurance or the risk management determinations of insurability is not authorized by a consumer protection statute or by
South Western Reporter, 2d Series. 1987 Apr 9 (date of decision);734:675-685. Unique Identifier : AIDSLINE KIE/27134
A Texas Court of Appeals held that a discovery order requiring a hospital to produce the names of the donors of blood transfused to a patient who contracted AIDS did not violate the blood donors rights of privacy. The court reasoned that in balancing the interest served by the state action with the donors interest
Federal Supplement. 1988 Mar 29 (date of decision);686:243-251. Unique Identifier : AIDSLINE KIE/27093
Ruling that an involuntary intrusion into the body by the state for purposes of withdrawing blood constitutes a search and seizure under the Fourth Amendment, the United States District Court for Nebraska held that the policy adopted by a multiple-county health services agency which re
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