IMMUNODEFICIENCY STATES: A PREDISPOSITION TO LYMPHOMA NLM AIDSLINE Important note: Information in this article was accurate in 1989. The state of the art may have changed since the publication date.

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IMMUNODEFICIENCY STATES: A PREDISPOSITION TO LYMPHOMA

Hodgkin's Disease and Non-Hodgkin's Lymphomas in Adults and Children. Fuller LM et al, eds. New York, Raven, p. 451-78, 1988.. Unique Identifier : AIDSLINE ICDB/89649525
Riggs S; Hagemeister FB; Dept. of Hematology, Univ. of Texas M.D. Anderson Hosp. and Tumor; Inst., Houston, TX 77030

Abstract: Evidence strongly suggests that persons who are immune deficient have an increased potential for developing both benign and malignant lymphoproliferative disorders. Whether the immune deficiency is congenital, acquired, or iatrogenic seems to be irrelevant. Disease states associated with lymphoma are reviewed, with emphasis on lymphoma in AIDS and AIDS-related complex, its manifestations, pathogenesis, clinical features, and management. Hereditary, environmental, and drug-related factors discussed include social class and familial clustering, industrial and agricultural chemicals, therapeutic and recreational drugs, human T-cell leukemia virus-I- and Epstein-Barr virus-endemic areas, and ionizing radiation. Prior lymphoproliferative or autoimmune diseases associated with an increased incidence of subsequent lymphoma include immunoblastic lymphadenopathy, rheumatoid arthritis, lupus erythematosus, chronic intestinal disorders (eg, celiac sprue), autoimmune hemolytic anemia or thrombocytopenia, and infectious mononucleosis. Congenital immunodeficiency syndromes, such as Wiscott-Aldrich, ataxia telangiectasia, combined immunodeficiency syndromes, and X-linked lymphoproliferative syndrome, are also associated with an increased risk of malignancy. The incidence of intermediate- to high-grade non-Hodgkin's lymphomas has increased in homosexual AIDS patients (pts), and the incidence of CNS involvement is striking. The authors recommend immediate biopsy of any enlarged nodes in immunosuppressed pts with lymphadenopathy. Pts found to have lymphoma should undergo immune, infectious disease, tumor-genetic, and staging evaluations, including CT scans of the brain. (159 Refs)
Keywords: Acquired Immunodeficiency Syndrome/IMMUNOLOGY Autoimmune Diseases/IMMUNOLOGY AIDS-Related Complex/IMMUNOLOGY Disease Susceptibility Hodgkin's Disease/ETIOLOGY/*IMMUNOLOGY/THERAPY Homosexuality Human Immune Tolerance Immunity, Cellular Infectious Mononucleosis/IMMUNOLOGY Intestinal Diseases/IMMUNOLOGY Lymphoma, Non-Hodgkin's/ETIOLOGY/*IMMUNOLOGY/THERAPY Risk Factors MONOGRAPH REVIEW, ACADEMIC REVIEW

KWDacquiredimmunodeficiencysyndrome/immunologyautoimmunediseases/immunologyaids-relatedcomplex/immunologydiseasesusceptibilityhodgkin'sdisease/etiology/KWDimmunology/therapyhomosexualityhumanimmunetoleranceimmunity,cellularinfectiousmononucleosis/immunologyintestinaldiseases/immunologylymphoma,non-hodgkin's/etiology/KWDimmunology/therapyriskfactorsmonographreview,academicreview
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Copyright © 1989 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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