Important note: Information in this article was accurate in 1989. The state of the art may have changed since the publication date.
VACCINES 88. NEW CHEMICAL AND GENETIC APPROACHES TO VACCINATION: PREVENTION OF AIDS AND OTHER VIRAL, BACTERIAL, AND PARASITIC DISEASES
Vaccines 88. New Chemical and Genetic Approaches to Vaccination: Prevention of AIDS and Other Viral, Bacterial, and Parasitic Diseases. Ginsberg H et al, eds. New York, Cold Spring Harbor Laboratory, 396 p., 1988.. Unique Identifier : AIDSLINE ICDB/89649755 Anonymous; No affiliation given
Abstract:
This volume includes the papers presented at the annual meeting on Modern Approaches to New Vaccines, held at Cold Spring Harbor, New York, on 9-13 September 1987. Sections cover immunology, parasitology, bacteria and bacterial diseases, virology, and AIDS. Among the specific topics included are: multivalent hepatitis-B synthetic vaccine; induction of antitumor immunity by immunization with vaccinia virus; recombinant vaccinia virus expressing the human melanoma-associated antigen p97; chimeric proteins based on hepatitis-B core antigen forming highly immunogenic particles; simian models for AIDS (simian immunodeficiency virus (SIV) and HIV-2 infection of macaques); attenuation of live recombinant vaccinia virus vectors by expression of human interleukin (IL)-2; virus epitopes that induce cytotoxic T lymphocytes recognized as short peptides and selected by class I major histocompatibility complex molecules; antigen-presenting cells controlling T-cell responsiveness to Friend murine leukemia virus envelope antigen; IL-2 as an adjuvant to vaccination; mapping of the principal HIV-neutralizing epitope; distinguishing features of neurotropic HIVs; functional role of CD8+ lymphocytes in SIV infection of rhesus monkeys; site-directed enzyme-linked immunosorbent assay; preparation and evaluation of a HIV gp120 prototype vaccine; transcriptional regulation of HIV type 1; HIV-specific T-cell immunity in seropositive, asymptomatic individuals; envelope gene variation in equine infectious anemia virus; functional analysis of the tat and trs genes of HIV by site-directed mutagenesis; functional analogies with cellular oncogene products; phylogenetic analysis of HIV-1 and HIV-2; synthetic peptide reagents distinguishing among infections caused by HIV strains; type-specific site-directed HIV serology; in vitro infection of macrophages by HIV; recombinant env and gag polypeptides characterizing HIV-1-neutralizing antibodies; identification of T-cell-specific epitopes in HIV; specific T-cell response toward viral antigens in gibbon apes infected with HIV; identification of HIV antigenic subtypes with relevance to AIDS vaccines; and an association between antibody to envelope glycoprotein gp120 and the outcome of HIV infection.
Keywords: Acquired Immunodeficiency Syndrome/*PREVENTION & CONTROL Animal Bacterial Infections/*PREVENTION & CONTROL Human Parasitic Diseases/*PREVENTION & CONTROL *Vaccination Vaccines/*ADMINISTRATION & DOSAGE Virus Diseases/*PREVENTION & CONTROL MONOGRAPH
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Important note: Information in this article was accurate in 1989. The state of the art may have changed since the publication date.
