SIMIAN MODELS FOR AIDS: SIV/SMM AND HIV-2 INFECTION OF MACAQUES NLM AIDSLINE Important note: Information in this article was accurate in 1989. The state of the art may have changed since the publication date.

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SIMIAN MODELS FOR AIDS: SIV/SMM AND HIV-2 INFECTION OF MACAQUES

Vaccines 88. New Chemical and Genetic Approaches to Vaccination: Prevention of AIDS and Other Viral, Bacterial, and Parasitic Diseases. Ginsberg H et al, eds. New York, Cold Spring Harbor Laboratory, p. 167-70, 1988.. Unique Identifier : AIDSLINE ICDB/89649759
Fultz PN; Switzer W; McClure HM; Anderson D; Montagnier L; AIDS Program, Centers for Disease Control, Atlanta, GA 30333

Abstract: Experiments involving infection of macaques with a simian immunodeficiency virus (SIV) isolate and with HIV-2 are reported, including course of the disease and laboratory and clinical data. SIV/SMM, isolated from sooty mangabey monkeys, was associated with a rapidly fatal disease. HIV-2 infections were established much less frequently than SIV/SMM infections, but continued serial passage in macaques may enhance infectivity of HIV-2EHO, which appears to be the most infectious for macaques of four strains tested. Infection of macaques with SIV appears to be an ideal model system for testing the efficacy of therapeutic drugs and prototype vaccines against T-lymphotropic lentiviruses. SIV possesses the same complex regulatory genes as HIV and causes a disease with symptoms typical of acquired immune deficiency syndrome. (8 Refs)
Keywords: Acquired Immunodeficiency Syndrome/IMMUNOLOGY/PREVENTION & CONTROL/*VETERINARY Animal Antibodies, Viral/ANALYSIS Disease Models, Animal HIV Antibodies/IMMUNOLOGY HIV Seropositivity/IMMUNOLOGY HIV-2/*IMMUNOLOGY Macaca/*IMMUNOLOGY Monkey Diseases/*IMMUNOLOGY Retroviridae Infections/IMMUNOLOGY/PREVENTION & CONTROL/ *VETERINARY SIV/*IMMUNOLOGY Vaccines, Synthetic/ADMINISTRATION & DOSAGE/*IMMUNOLOGY MEETING PAPER

KWDacquiredimmunodeficiencysyndrome/immunology/prevention&control/KWDveterinaryanimalantibodies,viral/analysisdiseasemodels,animalhivantibodies/immunologyhivseropositivity/immunologyhiv-2/KWDimmunologymacaca/KWDimmunologymonkeydiseases/KWDimmunologyretroviridaeinfections/immunology/prevention&control/KWDveterinarysiv/KWDimmunologyvaccines,synthetic/administration&dosage/KWDimmunologymeetingpaper
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M8930545

Copyright © 1989 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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