DISTINGUISHING FEATURES OF NEUROTROPIC HUMAN IMMUNODEFICIENCY VIRUSES NLM AIDSLINE Important note: Information in this article was accurate in 1989. The state of the art may have changed since the publication date.

Click here to return to AIDSLINE main menu
DonateNow
Print this Article


DISTINGUISHING FEATURES OF NEUROTROPIC HUMAN IMMUNODEFICIENCY VIRUSES

Vaccines 88. New Chemical and Genetic Approaches to Vaccination: Prevention of AIDS and Other Viral, Bacterial, and Parasitic Diseases. Ginsberg H et al, eds. New York, Cold Spring Harbor Laboratory, p. 259-63, 1988.. Unique Identifier : AIDSLINE ICDB/89649766
Cheng-Mayer C; Tateno M; Seto D; Levy JA; Cancer Res. Inst., Dept. of Medicine, Univ. of California Sch. of; Medicine, San Francisco, CA 94143

Abstract: In an attempt to identify a neurotropic subtype of HIV, the biologic and serologic properties of seven isolates from the CNS of individuals with and without neurologic symptoms were determined and compared to eight isolates from peripheral blood and lymph nodes. Distinct biologic and serologic properties of HIV isolates from the brain are described, and paired CNS and lymphocyte isolates are compared. HIV isolates from the brain can be distinguished from peripheral blood isolates by their (1) inability to infect established human T-cell lines, (2) relative sensitivity to serum neutralization, and (3) efficient replication in primary macrophages. The results support the hypothesis that HIV infection of the brain results from virus transport to this tissue by peripheral monocytes. Whether a specific cell type in the brain (glial or neurons) is particularly sensitive to HIV infection requires further investigation. In individuals with neurologic disorders, the presence of HIV variants with different biologic properties is likely. The present data suggest that isolates from the CNS in these individuals will be particularly tropic for macrophages and replicate less well in established human T-cell lines. (9 Refs)
Keywords: Acquired Immunodeficiency Syndrome/*IMMUNOLOGY Brain/IMMUNOLOGY Brain Diseases/*IMMUNOLOGY Cell Line Cytopathogenic Effect, Viral Human HIV/*IMMUNOLOGY/PHYSIOLOGY/PATHOGENICITY HIV Antibodies/CEREBROSPINAL FLUID *Neutralization Tests Plaque Assay Spinal Cord/IMMUNOLOGY Virus Replication MEETING PAPER

KWDacquiredimmunodeficiencysyndrome/KWDimmunologybrain/immunologybraindiseases/KWDimmunologycelllinecytopathogeniceffect,viralhumanhiv/KWDimmunology/physiology/pathogenicityhivantibodies/cerebrospinalfluidKWDneutralizationtestsplaqueassayspinalcord/immunologyvirusreplicationmeetingpaper
890330
M8930544

Copyright © 1989 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Boehringer Ingelheim, Bridgestone/Firestone Charitable Trust, Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1989. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1989. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .