PHYLOGENETIC ANALYSIS OF HIV-1 AND HIV-2 NLM AIDSLINE Important note: Information in this article was accurate in 1989. The state of the art may have changed since the publication date.

Click here to return to AIDSLINE main menu
DonateNow
Print this Article


PHYLOGENETIC ANALYSIS OF HIV-1 AND HIV-2

Vaccines 88. New Chemical and Genetic Approaches to Vaccination: Prevention of AIDS and Other Viral, Bacterial, and Parasitic Diseases. Ginsberg H et al, eds. New York, Cold Spring Harbor Laboratory, p. 317-21, 1988.. Unique Identifier : AIDSLINE ICDB/89649775
Smith TF; Marcus M; Myers G; MBCRR, Dana Farber Cancer Inst., Harvard Medical Sch., Boston, MA; 02115

Abstract: Phylogenetic tree analysis of the known HIV genomes was conducted using a maximum parsimony approach; the envelope-coding sequences of HIV-1 and HIV-2 were used to reconstruct what is believed to be the natural phylogenetic relationship among the HIV-1 and HIV-2 types sampled through 1985. It is evident from this analysis that AIDS virus diversification has come forward rather rapidly and that the HIV-1 and HIV-2 types may have diverged as recently as 50 or so years ago. An approximate mutation rate of 1%/yr and nucleotide differences between the two types of 40-60% were estimated. Insofar as the present calibrated tree is reliable, it appears that the viral diversification began to manifest itself in step with the rise of epidemics in Africa and North America. The possibility that the variation of the virus may be driven by the pandemic, and that the mutational rate may be a function of the growth rate of infectivity, is disturbing. Whether this is actually occurring, and whether an unprecedented ecological breakthrough has occurred recently, probably cannot be known for several years. The potential for variation may be great, even under the most favorable terms of constant mutation rate and a modest degree of recombination. (3 Refs)
Keywords: Base Sequence Genes, Viral Genetic Code Human HIV-1/*GENETICS HIV-2/*GENETICS Molecular Sequence Data Mutation *Phylogeny *Polymorphism (Genetics) Viral Envelope Proteins/GENETICS MEETING PAPER

KWDbasesequencegenes,viralgeneticcodehumanhiv-1/KWDgeneticshiv-2/KWDgeneticsmolecularsequencedatamutationKWDphylogenyKWDpolymorphism(genetics)viralenvelopeproteins/geneticsmeetingpaper
890330
M8930537

Copyright © 1989 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Boehringer Ingelheim, Bridgestone/Firestone Charitable Trust, Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1989. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1989. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .