SPECIFIC T-CELL RESPONSE TOWARD VIRAL ANTIGENS IN GIBBON APES (HYLOBATES LAR) INFECTED WITH HUMAN IMMUNODEFICIENCY VIRUS

Important note: Information in this article was accurate in 1989. The state of the art may have changed since the publication date.

SPECIFIC T-CELL RESPONSE TOWARD VIRAL ANTIGENS IN GIBBON APES (HYLOBATES LAR) INFECTED WITH HUMAN IMMUNODEFICIENCY VIRUS

Vaccines 88. New Chemical and Genetic Approaches to Vaccination: Prevention of AIDS and Other Viral, Bacterial, and Parasitic Diseases. Ginsberg H et al, eds. New York, Cold Spring Harbor Laboratory, p. 361-4, 1988.. Unique Identifier : AIDSLINE ICDB/89649782
Lusso P; Ranki A; Gallo RC; Krohn KJ; Markham PD; Kueberuwa SS; Lab. of Tumor Cell Biology, NCI, Bethesda, MD 20892

Abstract: The cellular immune response toward human immunodeficiency virus HIV-1 and its envelope and core proteins was studied in gibbon apes chronically infected with the human T-lymphotropic virus type IIIB (HTLV-IIIB) isolate of this virus. A T-cell proliferative response was observed in infected apes toward whole HTLV-IIIB virus and toward divergent isolates showing wide sequence variability, especially in the envelope glycoprotein gp120 (ie, HTLV-IIIRF and HTLV-IIIMN). A proliferative response also was induced by purified HTLV-IIIB native core protein p24 and envelope glycoprotein gp120 and by a synthetic peptide, p7, representing a highly conserved region of gp120. No response was observed by cells from infected control animals. After specific antigen stimulation, T cells from infected gibbon apes also secreted interleukin-2. Cells from infected animals displayed a selective cytotoxic activity against autologous cells expressing HIV-1 envelope or gag proteins. Consistent T-cell responses to HIV-1 antigens were demonstrated in gibbon apes, who, 10 mo after iv HIV-1 inoculation, had not developed typical hematological and clinical signs. It was noted that virus recovery from peripheral blood was more regular and rapid in two gibbon apes who generally displayed lower in vitro T-cell responses. HIV-infected humans seldom display a cellular response toward soluble HIV antigens, suggesting a possible explanation for the different natural histories of the infection in gibbon apes and in humans. (5 Refs)

Keywords: Acquired Immunodeficiency Syndrome/IMMUNOLOGY/*VETERINARY Animal Cytotoxicity, Immunologic Disease Models, Animal Hylobates/*IMMUNOLOGY HIV Antibodies/BIOSYNTHESIS HIV-1/*IMMUNOLOGY Interleukin-2/BIOSYNTHESIS Retroviridae Proteins/*IMMUNOLOGY T-Lymphocytes/*IMMUNOLOGY MEETING PAPER

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