Suppression of tuberculin skin reaction in healthy HTLV-I carriers from Japan. NLM AIDSLINE Important note: Information in this article was accurate in 1989. The state of the art may have changed since the publication date.

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Suppression of tuberculin skin reaction in healthy HTLV-I carriers from Japan.

Int J Cancer. 1988 Dec 15;42(6):829-31. Unique Identifier : AIDSLINE MED/89053519
Tachibana N; Okayama A; Ishizaki J; Yokota T; Shishime E; Murai K; Shioiri S; Tsuda K; Essex M; Mueller N; Second Department of Medicine, Miyazaki Medical School, Japan.

Abstract: Although it is thought that infection with human T-lymphotropic virus type I (HTLV-I) is immunosuppressive, this has not been clearly demonstrated among healthy carriers, and there are no data concerning delayed-type hypersensitivity (DTH). To evaluate this hypothesis, DTH to purified protein derivative (PPD) of tuberculin was measured in 126 healthy adults from an endemic area for HTLV-I infection in southern Japan. Among the 39 HTLV-I carriers, only 15% had detectable induration following PPD exposure, compared to 46% of the 87 non-carriers. In addition, the size of erythema among those carriers with a positive reaction was about 70% of that among non-carriers. Overall, there was a significantly inverse association between the degree of DTH response and prevalence of antibody. In relation to subjects with strong to moderate reaction, those with negative or indefinite reaction were 6 times more likely to be a carrier. This association was much stronger among subjects aged 60 years or older than among younger persons. These findings indicate that there is subclinical immunosuppression among HTLV-I carriers, which increases with age.
Keywords: Adult Age Factors Aged Carrier State/*IMMUNOLOGY Female Human Hypersensitivity, Delayed HTLV-I Infections/*IMMUNOLOGY *Immune Tolerance Male Middle Age Tuberculin Test JOURNAL ARTICLE

KWDadultagefactorsagedcarrierstate/KWDimmunologyfemalehumanhypersensitivity,delayedhtlv-iinfections/KWDimmunologyKWDimmunetolerancemalemiddleagetuberculintestjournalarticle
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Copyright © 1989 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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