Effects of HIV superinfection on HBV replication in a chronic HBsAg carrier with liver disease. NLM AIDSLINE Important note: Information in this article was accurate in 1989. The state of the art may have changed since the publication date.

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Effects of HIV superinfection on HBV replication in a chronic HBsAg carrier with liver disease.

J Hepatol. 1988 Oct;7(2):164-8. Unique Identifier : AIDSLINE MED/89054766
Pastore G; Santantonio T; Monno L; Milella M; Luchena N; Angarano G; Department of Internal Medicine and Infectious Diseases,; University of Bari, Italy.

Abstract: A case of HIV superinfection observed in an HBsAg/HBeAg-positive male homosexual with chronic persistent hepatitis is described. Soon after the appearance of clinical and serological features of acute HIV infection, a rapid fall to a normal value of ALT was noted with simultaneous recrudescence of HBV replication lasting for several months as detected by an increase of the HBV-DNA concentration in the serum. Our observations suggest that the reduction of hepatocyte necrosis and the increase in HBV replication were a consequence of impaired T cell function during acute HIV infection.
Keywords: Acquired Immunodeficiency Syndrome/*COMPLICATIONS Adult Antibodies, Monoclonal/DIAGNOSTIC USE Candidiasis, Oral/COMPLICATIONS *Carrier State Hepatitis B Surface Antigens/ANALYSIS Hepatitis B Virus/*PHYSIOLOGY Hepatitis, Chronic Active/*COMPLICATIONS Human Male *Superinfection Support, Non-U.S. Gov't *Virus Replication JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/KWDcomplicationsadultantibodies,monoclonal/diagnosticusecandidiasis,oral/complicationsKWDcarrierstatehepatitisbsurfaceantigens/analysishepatitisbvirus/KWDphysiologyhepatitis,chronicactive/KWDcomplicationshumanmaleKWDsuperinfectionsupport,non-uKWDsKWDgov'tKWDvirusreplicationjournalarticle
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M8930470

Copyright © 1989 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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