Human T cell leukemia viruses use a receptor determined by human chromosome 17. NLM AIDSLINE Important note: Information in this article was accurate in 1989. The state of the art may have changed since the publication date.

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Human T cell leukemia viruses use a receptor determined by human chromosome 17.

Science. 1988 Dec 16;242(4885):1557-9. Unique Identifier : AIDSLINE MED/89072736
Sommerfelt MA; Williams BP; Clapham PR; Solomon E; Goodfellow PN; Weiss RA; Chester Beatty Laboratories, Institute of Cancer Research,; London, U.K.

Abstract: Human T cell leukemia viruses (HTLV-I and HTLV-II) can infect many cell types in vitro. HTLV-I and HTLV-II use the same cell surface receptor, as shown by interference with syncytium formation and with infection by vesicular stomatitis virus (VSV) pseudotypes bearing the HTLV envelope glycoproteins. Human-mouse somatic cell hybrids were used to determine which human chromosome was required to confer susceptibility to VSV(HTLV) infection. The only human chromosome common to all susceptible cell hybrids was chromosome 17, and the receptor gene was localized to 17cen-qter. Antibodies to surface antigens known to be determined by genes on 17q did not block the HTLV receptor.
Keywords: Animal Cattle Cell Line Chromosome Mapping *Chromosomes, Human, Pair 17 *Genes, Structural Hamsters Human Hybrid Cells/CYTOLOGY/MICROBIOLOGY HTLV-I/*PHYSIOLOGY HTLV-II/*PHYSIOLOGY Mice Rats Receptors, Virus/*GENETICS Support, Non-U.S. Gov't JOURNAL ARTICLE

KWDanimalcattlecelllinechromosomemappingKWDchromosomes,human,pair17KWDgenes,structuralhamstershumanhybridcells/cytology/microbiologyhtlv-i/KWDphysiologyhtlv-ii/KWDphysiologymiceratsreceptors,virus/KWDgeneticssupport,non-uKWDsKWDgov'tjournalarticle
890330
M8930313

Copyright © 1989 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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