Charleston, S.C. : The Network, 1988 1 videocassette (57 min., 36 sec.) : sd., col. ; 3/4 in (Administrative grand rounds) Unique Identifier : AIDSLINE AV/8900108A
Bell FE; Buster L; Ziglar D; Lett V; Media Services; Network
(Producer) This program deals with proposed and existing standards of infection control as they relate to hospital and other health care employees. OSHA safety standards, and State and Federal categorization of employees will be explained.
New York, NY : American Foundation for AIDS Research, [1988] vi, 192 p Unique Identifier : AIDSLINE CAT/8901113
Halleron TA; Pisaneschi JI
Contains approximately 1100 educational and informational materials concerning AIDS, AIDS related illnesses, and HIV infection. Intended for all professional personnel and others interested in educational and informational materials. Describes brochures, pamphlets, posters, books, government reports, videotapes, and
London ; New York : Royal Society of Medicine Services, 1988 vii, 120 p. : ill (International congress and symposium series ; no. 135) Unique Identifier : AIDSLINE CAT/8901828
Hodgkin's Disease and Non-Hodgkin's Lymphomas in Adults and Children. Fuller LM et al, eds. New York, Raven, p. 451-78, 1988.. Unique Identifier : AIDSLINE ICDB/89649525
Riggs S; Hagemeister FB; Dept. of Hematology, Univ. of Texas M.D. Anderson Hosp. and Tumor; Inst., Houston, TX 77030
Evidence strongly suggests that persons who are immune deficient have an increased potential for developing both benign and malignant lymphoproliferative disorders. Whether the immune deficiency is congenital, acquired, or iatrogenic seems to be irrelevant. Disease states associated with lymphoma are reviewed, with em
Proceedings of the International Meeting on Recent Progress in Oncology. Volume 2. Latest Developments in Oncology. Di Martino L, ed. Italy, Ettore Gasperini Editore, p. 155-69, 1988.. Unique Identifier : AIDSLINE ICDB/89649605
Nethersell AB; Section of Oncology, Clinical Res. Dept., Wellcome Res.; Laboratories, Beckenham, Kent, UK
This review of interferons (IFNs) in cancer therapy covers the following topics: types and production of IFNs; possible modes of antitumor action, pharmacokinetics and pharmacodynamics, and side effects of alpha-IFNs; and clinical efficacy of alpha-IFNs (hairy cell leukemia, chronic granulocytic leukemia,
Vaccines 88. New Chemical and Genetic Approaches to Vaccination: Prevention of AIDS and Other Viral, Bacterial, and Parasitic Diseases. Ginsberg H et al, eds. New York, Cold Spring Harbor Laboratory, 396 p., 1988.. Unique Identifier : AIDSLINE ICDB/89649755
Anonymous; No affiliation given
This volume includes the papers presented at the annual meeting on Modern Approaches to New Vaccines, held at Cold Spring Harbor, New York, on 9-13 September 1987. Sections cover immunology, parasitology, bacteria and bacterial diseases, virology, and AIDS. Among the specific topics included are: multivalent hepatitis
Vaccines 88. New Chemical and Genetic Approaches to Vaccination: Prevention of AIDS and Other Viral, Bacterial, and Parasitic Diseases. Ginsberg H et al, eds. New York, Cold Spring Harbor Laboratory, p. 167-70, 1988.. Unique Identifier : AIDSLINE ICDB/89649759
Fultz PN; Switzer W; McClure HM; Anderson D; Montagnier L; AIDS Program, Centers for Disease Control, Atlanta, GA 30333
Experiments involving infection of macaques with a simian immunodeficiency virus (SIV) isolate and with HIV-2 are reported, including course of the disease and laboratory and clinical data. SIV/SMM, isolated from sooty mangabey monkeys, was associated with a rapidly fatal disease. HIV-2 infections were established muc
Vaccines 88. New Chemical and Genetic Approaches to Vaccination: Prevention of AIDS and Other Viral, Bacterial, and Parasitic Diseases. Ginsberg H et al, eds. New York, Cold Spring Harbor Laboratory, p. 259-63, 1988.. Unique Identifier : AIDSLINE ICDB/89649766
Cheng-Mayer C; Tateno M; Seto D; Levy JA; Cancer Res. Inst., Dept. of Medicine, Univ. of California Sch. of; Medicine, San Francisco, CA 94143
In an attempt to identify a neurotropic subtype of HIV, the biologic and serologic properties of seven isolates from the CNS of individuals with and without neurologic symptoms were determined and compared to eight isolates from peripheral blood and lymph nodes. Distinct biologic and serologic properties of HIV isolat
Vaccines 88. New Chemical and Genetic Approaches to Vaccination: Prevention of AIDS and Other Viral, Bacterial, and Parasitic Diseases. Ginsberg H et al, eds. New York, Cold Spring Harbor Laboratory, p. 265-9, 1988.. Unique Identifier : AIDSLINE ICDB/89649767
Letvin NL; Kannagi M; Harvard Medical Sch., New England Regional Primate Res. Center,; Southborough, MA 01772
Simian immunodeficiency virus (SIV) is a member of the same family of closely related lentiviruses that includes HIV-1 and HIV-2. All of the viruses of this family share similarities in nucleotide sequence and a tropism for CD4-bearing lymphocytes. The AIDS-like disease induced by SIV in rhesus monkeys was used as a m
Vaccines 88. New Chemical and Genetic Approaches to Vaccination: Prevention of AIDS and Other Viral, Bacterial, and Parasitic Diseases. Ginsberg H et al, eds. New York, Cold Spring Harbor Laboratory, p. 271-6, 1988.. Unique Identifier : AIDSLINE ICDB/89649768
Johnson PR; Purcell RH; Chanock RM; Parks DE; Norrby E; Lerner RA; Lab. of Infectious Diseases, NIAID, NIH, Bethesda, MD 20892
A diagnostic test was developed recently for human AIDS that utilizes synthetic peptides as solid-phase antigens in a site-directed enzyme-linked immunosorbent assay (ELISA). A similar ELISA was developed using a synthetic peptide from an analogous region of the simian immunodeficiency virus (SIV) transmembrane glycop
Vaccines 88. New Chemical and Genetic Approaches to Vaccination: Prevention of AIDS and Other Viral, Bacterial, and Parasitic Diseases. Ginsberg H et al, eds. New York, Cold Spring Harbor Laboratory, p. 277-82, 1988.. Unique Identifier : AIDSLINE ICDB/89649769
Arthur LO; Pyle SW; Bess JW Jr; Gilden RV; Nara PL; Robey WG; Fischinger PJ; Kelliher JC; Program Resources, Inc., NCI-Federick Cancer Res. Facility,; Frederick, MD 21701
The immune responses of chimpanzees immunized with a prototype HIV external glycoprotein vaccine were analyzed. Binding of gp120, the major envelope glycoprotein of HIV, to the CD4 molecules of T4-positive cells is considered an initial step in HIV infection and, as such, an immune response to gp120 may be effective i
Vaccines 88. New Chemical and Genetic Approaches to Vaccination: Prevention of AIDS and Other Viral, Bacterial, and Parasitic Diseases. Ginsberg H et al, eds. New York, Cold Spring Harbor Laboratory, p. 283-90, 1988.. Unique Identifier : AIDSLINE ICDB/89649770
Peterlin BM; Calman AF; Kao SY; Selby MJ; Tong-Starksen SE; Luciw PA; Howard Hughes Medical Inst., Dept. of Medicine, Univ. of; California, San Francisco, CA 94143
The present work demonstrated that T-cell-activation signals increase transcription from the long terminal repeat (LTR) of the San Francisco-2 isolate of HIV, designated here as HIV-1-LTR. It also was determined that the trans-activator (tat) acts as a transcriptional antiterminator that allows transcripts initiating
Vaccines 88. New Chemical and Genetic Approaches to Vaccination: Prevention of AIDS and Other Viral, Bacterial, and Parasitic Diseases. Ginsberg H et al, eds. New York, Cold Spring Harbor Laboratory, p. 291-5, 1988.. Unique Identifier : AIDSLINE ICDB/89649771
Linette G; Pierce P; Wong D; Wagner K; Smith E; Folks T; Hartzman R; Georgetown Univ. Sch. of Medicine, Washington, DC 20007
Cellular immunity to HIV was studied in seropositive individuals in a series of experiments: (1) screening of peripheral blood lymphocytes from HIV-seropositive and control seronegative individuals for in vitro proliferative responses to recall antigens (tetanus toxoid and influenza-A); (2) in vitro responses induced
Vaccines 88. New Chemical and Genetic Approaches to Vaccination: Prevention of AIDS and Other Viral, Bacterial, and Parasitic Diseases. Ginsberg H et al, eds. New York, Cold Spring Harbor Laboratory, p. 303-10, 1988.. Unique Identifier : AIDSLINE ICDB/89649773
Missense mutants were constructed using a subclone of HIV containing the tat- and trs-coding regions; the subclone was then substituted into the parent wild-type vector, HXB2gpt. To generate the mutants, site-directed mutagenesis was targeted to the three major structural motifs of the functional first coding region o
Vaccines 88. New Chemical and Genetic Approaches to Vaccination: Prevention of AIDS and Other Viral, Bacterial, and Parasitic Diseases. Ginsberg H et al, eds. New York, Cold Spring Harbor Laboratory, p. 317-21, 1988.. Unique Identifier : AIDSLINE ICDB/89649775
Smith TF; Marcus M; Myers G; MBCRR, Dana Farber Cancer Inst., Harvard Medical Sch., Boston, MA; 02115
Phylogenetic tree analysis of the known HIV genomes was conducted using a maximum parsimony approach; the envelope-coding sequences of HIV-1 and HIV-2 were used to reconstruct what is believed to be the natural phylogenetic relationship among the HIV-1 and HIV-2 types sampled through 1985. It is evident from this anal
Vaccines 88. New Chemical and Genetic Approaches to Vaccination: Prevention of AIDS and Other Viral, Bacterial, and Parasitic Diseases. Ginsberg H et al, eds. New York, Cold Spring Harbor Laboratory, p. 323-6, 1988.. Unique Identifier : AIDSLINE ICDB/89649776
Lyerly HK; Pratz JE; Tyler DS; Matthews TJ; Langlois AJ; Bolognesi DP; Weinhold KJ; Surgical Virology Lab., Dept. of Surgery, Duke Univ. Medical; Center, Durham, NC 27710
Studies were undertaken to demonstrate HIV-neutralizing capacity in patient (pt) sera and to compare the ability of the serum antibodies to (1) neutralize free virus; (2) inhibit cell fusion between HIV-infected cells and CD4+ cells; and (3) direct antibody-dependent cellular cytotoxicity (ADCC). These functions were
Vaccines 88. New Chemical and Genetic Approaches to Vaccination: Prevention of AIDS and Other Viral, Bacterial, and Parasitic Diseases. Ginsberg H et al, eds. New York, Cold Spring Harbor Laboratory, p. 341-5, 1988.. Unique Identifier : AIDSLINE ICDB/89649779
Gendelman HE; Martin MA; Orenstein J; Phipps T; Meltzer MS; Lab. of Molecular Microbiology, NIAID, NIH, Bethesda, MD 20892
HIV often leads to clinically overt disease following latency periods of months to years. Virus continually replicates in cells of the monocyte/macrophage lineage despite an often vigorous but ineffective host immune response. To study persistent HIV infection in macrophages, a system was developed for long-term maint
Vaccines 88. New Chemical and Genetic Approaches to Vaccination: Prevention of AIDS and Other Viral, Bacterial, and Parasitic Diseases. Ginsberg H et al, eds. New York, Cold Spring Harbor Laboratory, p. 361-4, 1988.. Unique Identifier : AIDSLINE ICDB/89649782
The cellular immune response toward human immunodeficiency virus HIV-1 and its envelope and core proteins was studied in gibbon apes chronically infected with the human T-lymphotropic virus type IIIB (HTLV-IIIB) isolate of this virus. A T-cell proliferative response was observed in infected apes toward whole HTLV-IIIB
Vaccines 88. New Chemical and Genetic Approaches to Vaccination: Prevention of AIDS and Other Viral, Bacterial, and Parasitic Diseases. Ginsberg H et al, eds. New York, Cold Spring Harbor Laboratory, p. 365-71, 1988.. Unique Identifier : AIDSLINE ICDB/89649783
Homsy J; Cheng-Mayer C; Tateno M; Levy JA; Cancer Res. Inst., Sch. of Medicine, Univ. of California, San; Francisco, CA 94143
Twenty HIV isolates were tested in a prototype study for their sensitivity to neutralization by human serum. A neutralization assay measuring the reduction of HIV infectivity in peripheral blood mononuclear cell cultures was used to define the HIV subgroups. Among the 20 HIVs studied, four neutralization-specific grou
AIDS in Children, Adolescents, and Heterosexual Adults: An Interdisciplinary Approach to Prevention. Schinazi RF, Nahmias AJ, eds. New York, Elsevier, 443 p., 1988.. Unique Identifier : AIDSLINE ICDB/89649785
Anonymous; No affiliation given
AIDS in children, adolescents, and heterosexual adults is covered in this volume, which is based on a conference held February 19-21, 1987 in Atlanta, Georgia, under the sponsorship of the International Interdisciplinary AIDS Foundation. Topics include public health challenges; legal, social, and religious issues; eco
AIDS in Children, Adolescents, and Heterosexual Adults: An Interdisciplinary Approach to Prevention. Schinazi RF, Nahmias AJ, eds. New York, Elsevier, p. 117-25, 1988.. Unique Identifier : AIDSLINE ICDB/89649786
Levy JA; Dept. of Medicine and Cancer Res. Inst., Univ. of California Sch.; of Med., San Francisco, CA 94143
HIV is a member of the third subfamily of human retroviruses, the lentivirinae. HIV does not transform cells in culture, does not readily infect fibroblasts, but replicates to a high titer in certain cell types, particularly T helper lymphocytes. The characteristics of HIV and its unique properties that represent a ch
AIDS in Children, Adolescents, and Heterosexual Adults: An Interdisciplinary Approach to Prevention. Schinazi RF, Nahmias AJ, eds. New York, Elsevier, p. 144-9, 1988.. Unique Identifier : AIDSLINE ICDB/89649788
Katz SL; Dept. of Pediatrics, Duke Univ. Medical Center, Durham, NC
There is no accumulated experience with vaccines for human retroviruses. The only animal retrovirus experience is controversial and concerns only feline leukemia virus. The historical background of vaccine development and other aspects of vaccines are discussed in relation to development of a vaccine for HIV. There is
Vaccines 88. New Chemical and Genetic Approaches to Vaccination: Prevention of AIDS and Other Viral, Bacterial, and Parasitic Diseases. Ginsberg H et al, eds. New York, Cold Spring Harbor Laboratory, p. 253-8, 1988.. Unique Identifier : AIDSLINE ICDB/89649765
Putney SD; Rusche JR; Javaherian K; Petro J; Lynn DL; O'Keeffe TJ; Grimaila R; McDanal C; Bolognesi DP; Matthews TJ; et al; Repligen Corp., Cambridge, MA 02139
The synthesis of recombinant HIV proteins and peptides and their ability to elicit and block neutralizing antibodies are described. Immune sera elicited by recombinant proteins gp160 and PB1 were assayed for the ability to block the fusion of HIV-infected cells with uninfected CD4+ lymphocytes. Either anti-gp160 or an
Vaccines 88. New Chemical and Genetic Approaches to Vaccination: Prevention of AIDS and Other Viral, Bacterial, and Parasitic Diseases. Ginsberg H et al, eds. New York, Cold Spring Harbor Laboratory, p. 297-302, 1988.. Unique Identifier : AIDSLINE ICDB/89649772
Payne SL; Ball JM; Issel CJ; Montelaro RC; Rushlow K; Dept. of Biochemistry, Louisiana State Univ., Baton Rouge, LA; 70803
Equine infectious anemia virus (EIAV) is a member of the lentivirus subfamily of retroviruses, which also includes visna virus, caprine arthritis encephalitis virus, and the simian and human immunodeficiency viruses. The extent and nature of env gene variation among four antigenically distinct EIAV isolates were exami
Vaccines 88. New Chemical and Genetic Approaches to Vaccination: Prevention of AIDS and Other Viral, Bacterial, and Parasitic Diseases. Ginsberg H et al, eds. New York, Cold Spring Harbor Laboratory, p. 327-33, 1988.. Unique Identifier : AIDSLINE ICDB/89649777
Gnann JW Jr; Nelson JA; Oldstone MB; McCormick JB; Dept. of Immunology, Res. Inst. of Scripps Clinic, La Jolla, CA; 92037
Synthetic peptides provide the basis for more specific immunodiagnostic assays that are needed to define more accurately the respective roles of HIV-1 and HIV-2 in the AIDS epidemic. Using synthetic peptides representing portions of various proteins encoded by the HIV-1 gag, pol, and env genes, the immunogenic epitope
Vaccines 88. New Chemical and Genetic Approaches to Vaccination: Prevention of AIDS and Other Viral, Bacterial, and Parasitic Diseases. Ginsberg H et al, eds. New York, Cold Spring Harbor Laboratory, p. 347-55, 1988.. Unique Identifier : AIDSLINE ICDB/89649780
Steimer KS; Van Nest GA; Haigwood NL; Tillson EM; George-Nascimento C; Barr PJ; Dina D; Chiron Corp., Emeryville, CA 94608
The strain specificities of affinity-purified human antibodies and animal antisera to a nonglycosylated HIV-SF2 polypeptide representing the gp120 region of the env genes were examined, and efforts were made to identify the target(s) of the HIV-SF2-neutralizing antibodies that do not bind to this antigen. Neutralizing
Vaccines 88. New Chemical and Genetic Approaches to Vaccination: Prevention of AIDS and Other Viral, Bacterial, and Parasitic Diseases. Ginsberg H et al, eds. New York, Cold Spring Harbor Laboratory, p. 357-60, 1988.. Unique Identifier : AIDSLINE ICDB/89649781
A central element in the antimicrobial immune response is the recognition of antigenic epitopes, in association with class II MHC antigens, by helper/inducer T cells; upon subsequent activation, these cells will induce antibody production and activation of T cells. Identification of the specific epitopes in HIV, which
Vaccines 88. New Chemical and Genetic Approaches to Vaccination: Prevention of AIDS and Other Viral, Bacterial, and Parasitic Diseases. Ginsberg H et al, eds. New York, Cold Spring Harbor Laboratory, p. 373-7, 1988.. Unique Identifier : AIDSLINE ICDB/89649784
Lee TH; Chou MJ; Huang JH; Yu XF; Allen J; McLane MF; Marlink R; Essex M; Redfield RR; Burke DS; et al; Dept. of Cancer Biology, Harvard Univ. Sch. of Public Health,; Boston, MA 02115
Several seroepidemiological studies are summarized with regard to response to gp120 antibody in HIV-infected individuals with different clinical manifestations, to determine if naturally produced gp120 antibodies correlated with the outcome of HIV infection. Two types of gp120-binding antibody occur: gp120(NR) and gp1
AIDS in Children, Adolescents, and Heterosexual Adults: An Interdisciplinary Approach to Prevention. Schinazi RF, Nahmias AJ, eds. New York, Elsevier, p. 126-43, 1988.. Unique Identifier : AIDSLINE ICDB/89649787
Schinazi RF; VA Medical Center, Atlanta, GA
The medical, social and economic impact of AIDS and associated diseases caused by HIV and the need to identify chemotherapeutic agents is self-evident. Strategies for prophylactic and therapeutic intervention to prevent, treat and control progression of the disease require understanding of the biologic and molecular p
Head DR; Kjeldsberg CR; Kadin ME; Pick T; Bybee B; Longbotham J; Shumski E; Department of Pathology, University of Utah Medical Center, Salt; Lake City 84132.
We describe two childhood cases of a T-cell malignancy indistinguishable from nonendemic, idiopathic adult T-cell leukemia/lymphoma. The cases illustrate the heterogeneity of nonendemic, idiopathic ATLL, including the presence of mediastinal masses and more heterogeneous immunologic markers than endemic cases, and rep
Cates W Jr; Division of Sexually Transmitted Diseases, Centers for Disease; Control, Atlanta, Georgia.
During the past 10 years, the field of sexually transmitted diseases has evolved from one emphasizing the traditional venereal diseases of gonorrhea and syphilis, to one concerned with the syndromes associated with Chlamydia trachomatis, herpes simplex virus, and human papillomavirus, and then to one preoccupied with
Wood RW; Collier A; Seattle-King County Department of Public Health, University of; Washington, Harborview Medical Center.
Acquired immunodeficiency syndrome (AIDS) is the lethal end stage of a sexually transmitted disease caused by a virus that is producing the major epidemic of our century. In this article we describe the history and epidemiology of AIDS and the disease states associated with infection with the human immunodeficiency vi
Rompalo AM; Quinn TC; Academic Department of Genito-Urinary Medicine, Middlesex; Hospital Medical School, London, England.
Intestinal infections represent a major health problem in homosexual men. The spectrum of potential pathogens includes classic sexually transmitted pathogens, enteric bacterial and protozoan pathogens, and a wide range of opportunistic infections seen in patients with human immunodeficiency virus (HIV) infections. Dia
Vogt MW; Hirsch MS; Infectious Disease Unit, Massachusetts General Hospital, Harvard; Medical School, Boston.
Effective antiviral drugs are urgently needed to treat individuals who are infected with the human immunodeficiency virus (HIV). Several compounds, such as nucleoside analogs ( AZT , ddCyd), phosphonoformate, and HPA-23 inhibit reverse transcriptase. Th
McKinlay MA; Otto MJ; Virology Section, Sterling-Winthrop Research Institute,; Rensselaer, New York.
As can be seen from the preceding brief discussion, the prospects for new antiviral agents for the treatment of viral diseases ranging in severity from the common cold to AIDS appear promising. The latest advances in technologies such as crystallography, genetic engineering, and monoclonal antibodies are all being app
Levine PH; Blattner WA; Division of Cancer Etiology, National Cancer Institute, Bethesda,; Maryland.
Considerable progress is being made in the understanding of at least two diseases associated with HTLV-I, ATLL and TSP. While laboratory methodology has not yet permitted comparable advances in identifying diseases associated with HTLV-II, if any, it is likely that a greater understanding of this and other retroviruse
Grierson HL; Purtilo DT; Eppley Institute for Research in Cancer and Allied Diseases.
At the present time there is no effective therapy for the HIV infection itself, nor for the opportunistic infections, malignancies, immune perturbations, and other manifestations of AIDS. However, as a result of knowledge gained regarding the modes of transmission of HIV, public health officials have made recommendati
Inaki S; Okamura H; Chikamori Y; Department of Otolaryngology, School of Medicine, Ehime, Japan.
A case of adult T-cell leukemia/lymphoma (ATLL) occurred in a 60-year-old woman who had a disturbance of right eye movement and visual acuity. She was born and lived in southwest Japan , an endemic area of ATLL. Rhinoscopic and roentgenologic examinations revealed a mass in the ethmo
Myrmel H; Haukenes G; Department of Microbiology and Immunology, Gade Institute,; University of Bergen, Norway.
A consistently positive ELISA reaction and a band in the gp41-region of the HIV-1 western blot were found in repeated serum samples from a healthy pregnant woman. The band was more clearly defined than the HIV gp41 band. Additional ELISA testing and repeated western blot analyses using different test kit batches confi
Braathen LR; Department of Dermatology, National Hospital, Oslo, Norway.
Langerhans cells are situated in epidermis of the skin and in all mucous membranes including oral, vaginal and cervical epithelium. Dendritic Langerhans-like cells are also present in lymphatics and draining lymph nodes. They are macrophage-like cells and play a major role in immunoregulation in these epithelia by pre
Fleming AF; Department of Tropical Medicine and Infectious Diseases,; Liverpool School of Tropical Medicine, UK.
The first generation of serological tests for anti-HIV-1 gave so many false positives with African sera that it was wrongly postulated that the virus was endemic in Africa. As there is no simian or other virus sufficiently closely related to HIV-1 as to suggest a recent common ancestor, the evolution of HIV-1 is obscu
Alfonso PG; Sanudo EF; Carretero JM; Galindo RC; Altozano JG; Gomez LP; Manga GP; Servicios de Oncologia, Hospital General Gregorio Maranon; Madrid, Spain.
Eight patients with Hodgkin s disease who were seropositive to human immunodeficiency virus (HIV), 6 of them being heroin addicts and one a homosexual, were studied. Histological examination showed 4 cases of lymphocytic depletion, 2 cases of mixed cellularity, 1 nodular sclerosis, and one not classifiable. There were
Cancer. 1988 Dec 15;62(12):2614-7. Unique Identifier : AIDSLINE MED/89051729
Taguchi H; Daibata M; Kitagawa T; Kubonishi I; Asai M; Sagara Y; Enzan H; Hara H; Miyoshi I; Department of Medicine, Kochi Medical School, Japan.
Generalized lymphadenopathy due to metastases of keratinizing squamous cell carcinoma developed in a 68-year-old woman who was a carrier of human T-cell leukemia Type I (HTLV-I). On her 74th hospital day, she died of massive metastases of the superficial and deep-seated lymph nodes, thyroid, lungs, pleura, liver, sple
Wasser LS; Shaw GW; Talavera W; Department of Medicine, Beth Israel Medical Center, New York, New; York 10011.
Although many of the pulmonary manifestations of tuberculosis in the acquired immunodeficiency syndrome (AIDS) are well known, endobronchial involvement has not been previously described. We report the clinical, roentgenographic, and bronchoscopic features of three patients with endobronchial tuberculosis and AIDS. Al
Ariza A; Kim JH; Section of Neuropathology, Yale University School of Medicine,; New Haven, CT 06510.
A case of Kaposi s sarcoma of the dura mater diagnosed by biopsy at craniotomy for subdural hematoma in an acquired immune deficiency syndrome (AIDS) patient is presented. This occurrence expands the scope of AIDS surgical neuropathology and alerts pathologists to the possibility of what could eventually be a more fre
Int J Cancer. 1988 Dec 15;42(6):829-31. Unique Identifier : AIDSLINE MED/89053519
Tachibana N; Okayama A; Ishizaki J; Yokota T; Shishime E; Murai K; Shioiri S; Tsuda K; Essex M; Mueller N; Second Department of Medicine, Miyazaki Medical School, Japan.
Although it is thought that infection with human T-lymphotropic virus type I (HTLV-I) is immunosuppressive, this has not been clearly demonstrated among healthy carriers, and there are no data concerning delayed-type hypersensitivity (DTH). To evaluate this hypothesis, DTH to purified protein derivative (PPD) of tuber
Int J Cancer. 1988 Dec 15;42(6):857-62. Unique Identifier : AIDSLINE MED/89053525
Schupbach J; Baumgartner A; Tomasik Z; Swiss National Center for Retroviruses, Institute of Immunology; and Virology, University of Zurich.
Sera from various Swiss population groups were tested for antibodies against the human T-cell leukemia virus type I (HTLV-I). Particle agglutination and ELISA were performed for screening; Western blot was done for confirmation. True-positive sera were found at a prevalence of 0.12% in a cohort of 846 individuals at r
Pastore G; Santantonio T; Monno L; Milella M; Luchena N; Angarano G; Department of Internal Medicine and Infectious Diseases,; University of Bari, Italy.
A case of HIV superinfection observed in an HBsAg/HBeAg-positive male homosexual with chronic persistent hepatitis is described. Soon after the appearance of clinical and serological features of acute HIV infection, a rapid fall to a normal value of ALT was noted with simultaneous recrudescence of HBV replication last
Buti M; Mas A; Sanchez-Tapias JM; Esteban R; Bruguera M; Allende H; Costa J; Guardia J; Rodes J; Liver Unit, Hospital Clinic, Universidad de Barcelona, Spain.
In recent years chronic infection by the hepatitis delta virus (HDV) has become an important cause of chronic liver disease among drug addicts. To evaluate the influence of addiction to i.v. drugs on the course of this disease we have analyzed the clinical, histopathological, virological and evolutive features in 18 a
Roman GC; Roman LN; Department of Neurology, Texas Tech University Health Sciences,; Center School of Medicine, Lubbock 79430.
Tropical spastic paraparesis (TSP) is a chronic and slowly progressive endemic myelopathy occurring in geographical isolates in the Caribbean, South India , South Africa , the Seychelles , and
Shibasaki H; Endo C; Kuroda Y; Kakigi R; Oda K; Komine S; Department of Internal Medicine, Saga Medical School, Japan.
Clinical and electrophysiological findings in 16 consecutive cases of HTLV-I associated myelopathy are reported. Symmetric spastic paraparesis associated with only mild hyperreflexia in the arms, clinical and electrophysiological evidence of moderate posterior column involvement at the thoracic level, urinary frequenc
Assogba U; Rey MA; Ancelle RM; Rottembourg J; Gluckman JC; Service de Nephrologie, Hopital de la Pitie, Paris.
A prospective multicenter study was undertaken between february 1985 and august 1986 in 4 haemodialysis centers in the Paris area ( France ) in order to assess the prevalence of HIV1 infection and the risk of transmission of the virus within the centers. Every four months a follow-up
Schietinger H; McCarthy P; Gillen M; Hammrich H; California Nurses Association, AIDS Education and Training, San; Francisco.
The AIDS epidemic is increasing the demand on all levels of health care staff to provide care compassionately and safely to people with AIDS and HIV infection. Only appropriate, ongoing education of all health care workers will maintain an effective health care system as the number of cases rises. However, the fear en
Proc Natl Acad Sci U S A. 1988 Dec;85(23):9224-8. Unique Identifier : AIDSLINE MED/89057908
Sadaie MR; Rappaport J; Benter T; Josephs SF; Willis R; Wong-Staal F; Laboratory of Tumor Cell Biology, National Cancer Institute,; Bethesda, MD 20892.
Single nucleotide alterations were introduced into an infectious clone of human immunodeficiency virus type 1 to create a series of missense mutants in the tat coding region. Although mutations in a proline-rich region and a basic lysine-arginine-rich region resulted in wild-type phenotypes, five of six mutations in a
Proc Natl Acad Sci U S A. 1988 Dec;85(23):9234-7. Unique Identifier : AIDSLINE MED/89057910
Karpas A; Hill F; Youle M; Cullen V; Gray J; Byron N; Hayhoe F; Tenant-Flowers M; Howard L; Gilgen D; et al; Department of Hematological Medicine, Cambridge University; Clinical School, United Kingdom.
Infection with the human immunodeficiency virus type 1 (HIV-1) is usually followed by a vigorous immune response that temporarily protects against disease progression. After a variable asymptomatic period, acquired immunodeficiency syndrome (AIDS)-related complex (ARC) and AIDS develop in most infected individuals. We
Proc Natl Acad Sci U S A. 1988 Dec;85(23):9283-6. Unique Identifier : AIDSLINE MED/89057920
Pal R; Gallo RC; Sarngadharan MG; Department of Cell Biology, Bionetics Research, Inc., Rockville,; MD 20850.
The synthesis and processing of structural proteins of human immunodeficiency virus type 1 (HIV-1) were studied in infected cells treated with monensin and cerulenin. In MOLT-3 cells chronically infected with HTLV-IIIB, monensin inhibited the proteolytic cleavage of the env-coded polyprotein gp160 to gp120, leading to
Uldry PA; Regli F; Centre Hospitalier Universitaire Vaudois, Lausanne, Suisse.
Cranial neuropathies were present in 5 patients with positive serology for the human immunodeficiency virus. Two patients presented with abnormalities of ocular movements (3rd, 4th), two with an isolated unilateral facial nerve palsy and one with a lesion of the accessory nerve. Neurological symptoms and signs are pre
Giesecke J; Scalia-Tomba G; Furucrona A; Department of Infectious Diseases, Karolinska Institute, Danderyd; Hospital, Sweden.
The probability of acquiring an HIV infection through different types of risk behaviour is not well known. For prognoses on the future spread of the infection some knowledge of these probabilities is of vital importance. While they may be difficult to ascertain directly, comparison with better known diseases that are
Perkins HA; Samson S; Busch MP; Irwin Memorial Blood Bank, San Francisco, California 94118.
Review of the dates of prior blood donation by persons later reported to have AIDS demonstrated that most of them had ceased donating blood in 1983. The results indicate that self-exclusion policies were effective.
Am J Ophthalmol. 1988 Dec 15;106(6):653-67. Unique Identifier : AIDSLINE MED/89060399
Holland GN; Engstrom RE Jr; Glasgow BJ; Berger BB; Daniels SA; Sidikaro Y; Harmon JA; Fischer DH; Boyer DS; Rao NA; et al; AIDS Unit, UCLA Uveitis Center, Jules Stein Eye Institute; 90024-1771.
In seven of eight cases of presumed ocular toxoplasmosis in patients with AIDS, the diagnosis was supported by a reduction or resolution of intraocular inflammation and healing of necrotic retinal lesions after initiation of antiparasitic drug therapy including one or more of the following medications: pyrimethamine,
Am J Ophthalmol. 1988 Dec 15;106(6):740-1. Unique Identifier : AIDSLINE MED/89060414
Rehder JR; Burnier MB Jr; Pavesio CE; Kim MK; Rigueiro M; Petrilli AM; Belfort R Jr; Department of Ophthalmology, Escola Paulista de Medicina, Sao; Paulo, Brazil.
Yajko DM; Kirihara J; Sanders C; Nassos P; Hadley WK; Department of Laboratory Medicine, University of California, San; Francisco General Hospital Medical Center 94110.
Pairs of 11 antimicrobial agents were tested in vitro for their ability to act synergistically against three strains of Mycobacterium avium complex isolated from patients with acquired immune deficiency syndrome. From the combinations tested, four drugs (ethambutol, rifampin, ciprofloxacin, and erythromycin) were sele
Ninane J; Grymonprez A; Burtonboy G; Francois A; Cornu G; Department of Paediatric Haematology and Oncology, Cliniques; Universitaires Saint-Luc, Brussels, Belgium.
A boy, born to a mother with AIDS related complex, was immunised with BCG on the 10th day of life. At the age of 4 months he presented with a local enlarged lymph node, fever, hypotonia, and diarrhoea. Mycobacterium bovis, BCG strain, was grown from the lymph node and cerebrospinal fluid; this proved dissemination.
Raviglione MC; Battan R; Taranta A; Department of Medicine, Cabrini Medical Center, New York, NY; 10003.
To study the outcome of cardiopulmonary resuscitation (CPR) in patients with acquired immunodeficiency syndrome (AIDS), data on CPR in hospitalized patients were collected prospectively during a one-year study period. Of 43 consecutive patients with AIDS who underwent CPR, 23% were revived in the initial attempt, wher
Younger DS; Chou S; Hays AP; Lange DJ; Emerson R; Brin M; Thompson H Jr; Rowland LP; Department of Neurology, Columbia Presbyterian Medical Center,; New York 10032-3784.
Adults with slowly progressive noninherited gait disorders may show no abnormalities on examination other than signs implicating the corticospinal tracts. That is the syndrome of primary lateral sclerosis (PLS), a clinical diagnosis that has been avoided because it is a diagnosis of exclusion, proven only at autopsy.
AIDS Res Hum Retroviruses. 1988 Oct;4(5):343-50. Unique Identifier : AIDSLINE MED/89062030
Robert-Guroff M; Goedert JJ; Naugle CJ; Jennings AM; Blattner WA; Gallo RC; Laboratory of Tumor Cell Biology, National Cancer Institute,; Bethesda, MD 20892.
Serum samples collected prospectively between 1982 and 1987 from a cohort of homosexual men were analyzed for HIV-1 neutralizing antibodies. Seven seroconverters who became infected between 1982 and 1984 and 12 seroprevalents who were already seropositive in 1982 remained free of AIDS. During the 6 year period, 1 sero
AIDS Res Hum Retroviruses. 1988 Oct;4(5):351-8. Unique Identifier : AIDSLINE MED/89062031
Chiodi F; Albert J; Olausson E; Norkrans G; Hagberg L; Sonnerborg A; Asjo B; Fenyo EM; Department of Virology, Karolinska Institute, Stockholm, Sweden.
Isolation of the human immunodeficiency virus (HIV) has been attempted from the cerebrospinal fluid (CSF) of 63 subjects at different stages of HIV infection, including asymptomatic carriers and patients with or without neurologic or psychiatric complications. In addition blood was collected from 40 of these subjects
Chirgwin K; Rao TK; Landesman SH; Friedman EA; Department of Medicine, SUNY-HSC, Brooklyn.
A preliminary study of 86 patients undergoing maintenance hemodialysis in an urban unit serving a large number of intravenous drug addicts revealed that the HIV seroprevalence rate was 27% (27 of 70 screened). Twenty-three of 26 (89%) positive patients were intravenous addicts, and the remaining four included Haitian
Huang CM; Ruddel M; Elin RJ; Clinical Pathology Department, Warren Grant Magnuson Clinical; Center, Bethesda, MD 20892.
We determined the enzyme activities of glucose-6-phosphate isomerase, alanine aminotransferase, aspartate aminotransferase, and lactate dehydrogenase in serum from 23 normal controls, 27 anti-HIV seropositive individuals confirmed by Western blot, and 53 patients with acquired immunodeficiency syndrome (AIDS). There i
Boucher CA; de Gans J; van Oers R; Danner S; Goudsmit J; Human Retrovirus Laboratory, Academic Medical Center, Amsterdam,; The Netherlands.
A 58-year-old patient suffering from Guillain-Barre syndrome was successfully treated with plasma exchange therapy. Two- and half year later she developed AIDS. The only risk factor of this patient was plasmapheresis and it appeared, retrospectively, that one of the plasma donor samples contained antibodies to HIV. Kn
Int J Immunopharmacol. 1988;10(6):695-707. Unique Identifier : AIDSLINE MED/89066056
Zhang HX; Sozzani S; D'Alessandro F; Luini W; Vecchi A; Spreafico F; Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
The in vitro effects of suramin, a compound recently tested in AIDS treatment, were investigated on human and murine NK and monocyte macrophage cytotoxicity and monocyte migratory ability. In a short-term, TNF-dependent assay, pre-exposure (4-18 h) to 100-400 micrograms/ml suramin was associated with a markedly increa
Tanabe A; Nakashima H; Yoshida O; Yamamoto N; Tenmyo O; Oki T; Department of Virology and Parasitology, Yamaguchi University; School of Medicine, Japan.
Swanson SK; Mento SJ; Weeks-Levy C; Brock BD; Kowal KJ; Wallace RE; Ritchey MB; Cano FR; Lederle Laboratories Division, American Cyanamid Company, Pearl; River, New York 10965.
A cell line used in the production of biologicals should be free of infectious agents, and described with respect to cytogenetic characteristics and tumorigenicity . Vero, a continuous cell line derived from a normal African green monkey kidney, was examined for the presence of retroviruses and for tumorigenic potent
Crofts N; Maskill W; Gust ID; National HIV Reference Laboratory, Fairfield Hospital, Victoria,; Australia.
Diagnostic tests are usually evaluated in terms of simple qualitative measures of sensitivity and specificity. When comparing different quantitative assays such as ELISAs, it is often more useful to deal with actual values (sample optical density/cut-off optical density ratio (OD ratio] rather than the qualitative rel
Maskill WJ; Crofts N; Waldman E; Healey DS; Howard TS; Silvester C; Gust ID; National HIV Reference Laboratory, Fairfield Hospital, Victoria,; Australia.
Two competitive anti-HIV ELISA screening assays (Behring and Wellcozyme) and two second generation assays using antigens generated by recombinant DNA technology (Abbott) and synthetic peptides (Biochrom) were evaluated against common panels of anti-HIV positive sera and sera known or thought likely to give false posit
A subacute encephalitis is increasingly recognized to be the most frequent cerebral manifestation of human immunodeficiency virus (HIV) infection. Contradictory reports are given in the literature concerning its clinical course. In the present study, a group of 19 patients with subacute encephalitis was followed for a
Biniek R; Gesemann H; Scheiermann M; Brockmeyer NH; Lehmann HJ; Department of Neurology, RWTH Aachen, F.R.G.
The relative concentrations of human immunodeficiency virus (HIV) antibodies in relation to equal IgG contents of 46 serum cerebrospinal fluid (CSF) samples from 32 patients were determined by serial dilution in an anti-HIV enzyme-linked immunosorbent assay (ELISA). The ratio of CSF and the serum HIV antibody concentr
Skotzek B; Sander T; Zimmermann J; Kolmel HW; Department of Neurology, Universitatsklinikum Rudolf-Virchow,; Freie Universitat Berlin, F.R.G.
Matched samples of serum and cerebrospinal fluid (CSF) from 15 human immunodeficiency virus (HIV)-infected patients were examined after isoelectric focusing. The appearance of oligoclonal bands only in the CSF could indicate the primary HIV infection of CNS in early stages of the disease. Later, the increasing number
Riedel RR; Clarenbach P; Bulau P; Helmstedter C; Brackmann HH; Niese D; Norra C; Department of Neurology, University Clinic, Bonn, F.R.G.
Human immunodeficiency virus (HIV)-seropositive patients show involvement of the central and/or peripheral nervous system. We present here the results of electroencephalographic (EEG) findings in stage WR 1-5 HIV-seropositive hemophiliacs from a total of 184 who attended our clinic prior to October 1987.
Scheppler JA; Mawle AC; McDougal JS; Division of Host Factors, Centers for Disease Control, Atlanta,; GA 30333.
The T cell line, CEM-E5, acutely and chronically infected with HIV-1, was used as a target cell in a standard 51Cr release HIV-1-specific antibody-dependent cellular cytotoxicity (ADCC) assay. CEM-E5, acutely infected with HIV-1, showed peak sensitivity to lysis in an HIV-1 specific ADCC assay on day 9 after infection
Abbott MA; Poiesz BJ; Byrne BC; Kwok S; Sninsky JJ; Ehrlich GD; Department of Medicine, SUNY Health Science Center 13210.
We evaluated various detection methods to identify amplified human retroviral sequences after Thermus aquaticus-directed polymerase chain reaction (PCR). A combination of hybridization formats and direct incorporation assays provided the most information. This multiphasic approach enabled us to detect specific human T
Kwok S; Kellogg D; Ehrlich G; Poiesz B; Bhagavati S; Sninsky JJ; Department of Infectious Diseases, Cetus Corporation, Emeryville,; California 94608.
DNA from peripheral blood mononuclear cells of individuals with chronic progressive myelopathy (CPM) were extensively analyzed for the presence of human T cell leukemia virus (HTLV) type I-like sequences by using the polymerase chain reaction. The DNA samples were amplified with oligonucleotides from three separate re
Agius G; Biggar RJ; Alexander SS; Waters DJ; Drummond JE; Murphy EL; Weiss SH; Levine PH; Blattner WA; Viral Epidemiology Section, National Cancer Institute, Bethesda,; Maryland 20892.
Detection of human T lymphotropic virus type I (HTLV-I) antibody was assessed on 368 sera from subjects with different clinical features and from different parts of the world. Enzyme-linked immunosorbent assay (ELISA) and radioimmunoassay for purified p24 antibodies (p24-RIA) used as screening tests agreed in 88.7% of
Rajaratnam K; Desai S; Mpilo Central Hospital, Bulawayo, Zimbabwe.
The most common tracheal neoplasms are epidermoid carcinomas, papillomas and cylindromas. Kaposi s sarcoma, confined primarily to the trachea, is one of the rarest tumours. The clinical and histological picture of a case of Kaposi s sarcoma of the trachea in a young, pregnant woman, presenting with severe airway obstr
Seto A; Kawanishi M; Matsuda S; Ogawa K; Department of Microbiology, Shiga University of Medical Science,; Otsu, Japan.
Six HTLV-I-transformed T cell lines were prepared from PBL of three rabbits each of B/J and Chbb:HM strains, and were inoculated into newborn rabbits of these two strains, and of their F1 hybrid. None of three B/J cell lines induced anti-HTLV-I antibody response in newborn B/J rabbits, whereas all three Chbb:HM cell l
Mayo Clin Proc. 1988 Dec;63(12):1251-5. Unique Identifier : AIDSLINE MED/89069708
Gracey DR; Division of Thoracic Diseases, Mayo Clinic, Rochester, MN 55905.
Tuberculosis remains a major public health problem throughout the world. Although the disease was previously well controlled in the United States , several factors now present a potential for the reemergence of tuberculosis as a significant public health concern. Physicians who will be
Med Hypotheses. 1988 Oct;27(2):147-8. Unique Identifier : AIDSLINE MED/89070347
Shoemaker JP; Department of Biological Sciences, Ashland Community College,; University of Kentucky 41101.
The role of retroviruses as causal agents in animal and human neoplasms is reviewed. Based on previous studies done on retrovirus caused mouse mammary adenocarcinoma, it is suggested that a treatment regimen with 6-propylthiouracil, chloroquine phosphate and 5-fluorouracil (which resulted in 77% and 65% complete mouse
Nature. 1988 Dec 8;336(6199):575-7. Unique Identifier : AIDSLINE MED/89070676
Auger I; Thomas P; De Gruttola V; Morse D; Moore D; Williams R; Truman B; Lawrence CE; Wadsworth Center for Laboratories and Research, New York State; Department of Health, Albany 12201.
A recent seroprevalence study of newborns indicates that one in 62 children born in New York City has antibodies to the human immunodeficiency virus (HIV). The distribution of incubation periods for paediatric patients is needed to estimate future AIDS case loads from these seroprevalence data. Current estimates of in
Gray F; Gherardi R; Keohane C; Favolini M; Sobel A; Poirier J; Departement de Pathologie (Neuropathologie), Hopital Henri; Mondor, Creteil, France.
The central nervous system was examined in 40 AIDS patients who died between August 1982 and 1987. The cases included two children born to intravenous drug abusers and 38 male adults. The brains of eight patients who had no clinical or radiological evidence of central nervous system involvement showed non-specific cha
Vinters HV; Guerra WF; Eppolito L; Keith PE 3d; Department of Pathology, UCLA Medical Center 90024-1732.
A patient with AIDS-related complex (ARC) presented with a fulminant neurologic syndrome suggestive of ascending myelopathy, and died approximately 48 h after admission to hospital. At necropsy, there was evidence of a severe necrotizing vasculitis affecting the nervous system most severely, with multifocal haemorrhag
Boccellari A; Dilley JW; Shore MD; Department of Psychiatry, San Francisco General Hospital,; University of California 94110.
The AIDS Dementia Complex (ADC) frequently occurs in individuals with Acquired Immunodeficiency Syndrome (AIDS). We report on a clinical series of 33 patients with either AIDS or AIDS-Related Complex (ARC), who were referred for neuropsychological evaluation. This clinical series supports the developing understanding
Postgrad Med J. 1988 May;64(751):405-6. Unique Identifier : AIDSLINE MED/89071617
Ediger SK; Isley WL; Department of Medicine, University of Missouri-Kansas City School; of Medicine 64108.
Rifampicin, an antituberculous drug, causes increased hepatic metabolism of steroid hormones. We report the case of a patient with the acquired immunodeficiency syndrome treated with rifampicin who had a normal screening test for adrenal insufficiency, yet had clinical evidence of adrenal failure. Diagnostic testing
Proc Natl Acad Sci U S A. 1988 Dec;85(24):9406-10. Unique Identifier : AIDSLINE MED/89071707
Gaynor RB; Kuwabara MD; Wu FK; Garcia JA; Harrich D; Briskin M; Wall R; Sigman DS; Department of Medicine, School of Medicine, University of; California, Los Angeles 90024.
The enhancer element of the human immunodeficiency virus type I (HIV-I) long terminal repeat (LTR) contains two copies of nearly identical sequences AGGGACTTTCC (3G sequence) and GGGGACTTTCC (4G sequence) that are important in transcriptional regulation. A single copy of the 4G sequence is found in the NF-kappa B site
Proc Natl Acad Sci U S A. 1988 Dec;85(24):9763-7. Unique Identifier : AIDSLINE MED/89071776
Karpatkin S; Nardi M; Lennette ET; Byrne B; Poiesz B; New York University Medical School, NY 10016.
Patients with human immunodeficiency virus type 1 (HIV-1) infection develop an immunologic thrombocytopenic purpura associated with markedly elevated platelet IgG, IgM, and C3C4 as well as serum immune complexes determined by the polyethylene glycol (PEG) method. Analysis of their serum PEG-precipitable immune complex
Dobloug JH; Gerner NW; Hurlen B; Bruun JN; Skaug K; Department of Infectious Diseases, Ullevaal Hospital, Oslo,; Norway.
The risk for dental hygienists to contract HIV and hepatitis B infection at work was studied in an international cohort of 167 dental hygienists from 13 countries. A significant proportion of the hygienists had taken care of HIV-positive patients or patients known to be at risk for contracting HIV infection. None of t
14 of 18 HIV-positive blood donors clearly belonged to high-risk groups. Disturbingly, 12 of these 18 persons donated during the 2-month period following the announcement of systematic testing in blood banks and two nationwide AIDS educational programmes. Such programmes may prompt exposed subjects to donate in order
Science. 1988 Dec 16;242(4885):1554-7. Unique Identifier : AIDSLINE MED/89072735
Somasundaran M; Robinson HL; Department of Pathology, University of Massachusetts Medical; Center, Worcester 01655.
The expression of a laboratory strain of HIV-1 (HTLV-IIIB) has been studied in mitogen-stimulated peripheral blood lymphocytes (PBLs) and in two lymphoid cell lines (CEM cells and C8166 cells). HIV-expressing cells contained from 300,000 to 2,500,000 copies of viral RNA per cell. Near-synchronous expression of an acti
Science. 1988 Dec 16;242(4885):1557-9. Unique Identifier : AIDSLINE MED/89072736
Sommerfelt MA; Williams BP; Clapham PR; Solomon E; Goodfellow PN; Weiss RA; Chester Beatty Laboratories, Institute of Cancer Research,; London, U.K.
Human T cell leukemia viruses (HTLV-I and HTLV-II) can infect many cell types in vitro. HTLV-I and HTLV-II use the same cell surface receptor, as shown by interference with syncytium formation and with infection by vesicular stomatitis virus (VSV) pseudotypes bearing the HTLV envelope glycoproteins. Human-mouse somati
Science. 1988 Dec 23;242(4886):1665-70. Unique Identifier : AIDSLINE MED/89072752
Leonard JM; Abramczuk JW; Pezen DS; Rutledge R; Belcher JH; Hakim F; Shearer G; Lamperth L; Travis W; Fredrickson T; et al; Laboratory of Molecular Microbiology, National Institute of; Allergy and Infectious Diseases, Bethesda, MD 20892.
Transgenic mice containing intact copies of the human immunodeficiency virus (HIV) proviral DNA were constructed. Founder animals were not viremic for HIV and remained healthy during a 9-month observation period. After being mated with nontransgenic animals, one founder mouse (No. 13) gave rise to F1 progeny that deve
Science. 1988 Dec 23;242(4886):1684-6. Unique Identifier : AIDSLINE MED/89072755
Namikawa R; Kaneshima H; Lieberman M; Weissman IL; McCune JM; Department of Pathology, Stanford University School of Medicine,; CA 94305.
SCID-hu mice with human fetal thymic or lymph node implants were inoculated with the cloned human immunodeficiency virus-1 isolate, HIV-1JR-CSF. In a time- and dose-dependent fashion, viral replication spread within the human lymphoid organs. Combination immunohistochemistry and in situ hybridization revealed only vir
South Med J. 1988 Dec;81(12):1496-8. Unique Identifier : AIDSLINE MED/89072852
Prichard JG; Nelson MJ; Burns L; Kaplowitz HJ; Caillouet BL; Sanchez MA; Institute for Immunological Disorders, University of Texas Health; Science Center, Houston.
We assessed infectious complications of long-term percutaneous central venous catheterization in patients with acquired immunodeficiency syndrome (AIDS). We evaluated 98 consecutive patients, accounting for 6,298 catheter days. Catheter-associated bacteremia occurred in 3% of patients, a rate of 0.128%/patient-cathete
Burger RA; Gerharz CD; Jansen N; Engelmann U; Department of Urology, University Hospital, Mainz, FRG.
A comparative study was undertaken to investigate the Nd:YAG and CO2 laser systems for laser-assisted vasovasostomies (LAVs). In 32 rats 64 vasovasostomies were performed, either conventionally sutured (CSV) or laser-welded (LAV-CO2 and LAV-Nd:YAG). Postoperative investigations included patency tests, gross examinatio
Wien Med Wochenschr. 1988 Oct 31;138(19-20):477-9. Unique Identifier : AIDSLINE MED/89073819
Chin J; Luger A; Department Surveillance, Forecasting and Impact Assessment, World; Health Organization Headquarters, Genf, Schweiz.
An analysis of the distribution of HIV-infections in different countries permits to distinguish 3 different patterns. Type 1 occurs in North America, Western Europe, parts of South America, Australia and New Zealand . Type 2 is found in Af
Histological and electron-microscopic studies were conducted into biopsy material from cases of what is called the classical type of idiopathic Kaposi s sarcoma without acquired immunodeficiency syndrome. Ultrastructural analysis was conducted, with the view to characterizing a possible progenitor cell from which the
Tovo PA; Gabiano C; Favro-Paris S; Palomba E; Gajno G; Department of Paediatrics, University of Turin, Italy.
An 18-month-old girl with AIDS related complex following congenital HIV infection suffered since the first days of life from severe neurological disturbances. The extensive congenital brain atrophy and the diffuse intracranial calcification which were found were strongly reminiscent of intrauterine infection. Since th
Am J Pathol. 1988 Dec;133(3):498-506. Unique Identifier : AIDSLINE MED/89074712
Baroni CD; Pezzella F; Pezzella M; Macchi B; Vitolo D; Uccini S; Ruco LP; Second Chair of Pathological Anatomy, University La Sapienza,; Rome, Italy.
Monoclonal antibodies (MAb) anti-HIV core and envelope proteins and in situ hybridization, using cDNA HIV probe, were employed to determine which lymph node cells in LAS patients express viral antigens and viral nucleic acids. The results have been correlated with the histologic phases of LAS and with the germinal cen
Rubinstein I; Colapinto N; Rotstein LE; Brown IG; Hoffstein V; Department of Medicine, St. Michael's Hospital, Toronto, Canada.
Overweight patients with obstructive sleep apnea (OSA) are improved by weight reduction, although the underlying mechanisms are not clear. We tested the hypothesis that improvement in OSA after weight loss is associated with improvement in pharyngeal function. Consequently, we measured pharyngeal area at functional re
Agostini C; Poletti V; Zambello R; Trentin L; Siviero F; Spiga L; Gritti F; Semenzato G; Department of Clinical Medicine, First Medical Clinic, Padua,; Italy.
The lungs of patients with acquired immunodeficiency syndrome (AIDS) are frequently affected by opportunistic and nonopportunistic infections and pulmonary localizations of Kaposi s sarcoma. The aim of this study was to verify whether, in patients with human immunodeficiency virus (HIV) infections, immunologic pulmona
The authors present a series of 51 cases of buccopharyngeal Kaposi s sarcoma observed in patients with AIDS. The diagnosis of Kaposi s sarcoma is generally obvious due to its appearance, its constantly violaceous colour and its site, especially palatine and velar. When Kaposi s sarcoma is the first manifestation of th
Kohan D; Rothstein SG; Cohen NL; Department of Otolaryngology, New York University Medical Center,; NY 10016.
A 5-year retrospective study evaluating otologic disease in patients with acquired immunodeficiency syndrome (AIDS) was conducted at the New York University Medical Center-Bellevue Hospital Center. Twenty-six patients with documented otologic disease who met the Centers for Disease Control criteria for AIDS were ident
We observed 276 HIV-infected patients to determine the frequency, degree, and clinical presentation of the lymphocytic alveolitis in different stages of HIV disease, and also to identify the lymphocyte subsets involved. In 154 patients with proved lung infections or tumors (group A), bronchoalveolar lavage fluid showe
Bibler MR; Chou TC; Toltzis RJ; Wade PA; Department of Internal Medicine, University of Cincinnati College; of Medicine 45267-0535.
Although pentamidine isethionate is effective in the treatment of Pneumocystis carinii pneumonia, it frequently causes serious adverse reactions. We report a case of reversible pentamidine-induced cardiotoxicity, characterized electrocardiographically by prolongation of the QT interval, T-wave inversion, and electrica
Costa DC; Ell PJ; Burns A; Philpot M; Levy R; Institute of Nuclear Medicine, University College, Middlesex; School of Medicine, London U.K.
We present preliminary data on the utility of functional brain imaging with [99mTc]-d,l-HM-PAO and single photon emission computed tomography (SPECT) in the study of patients with dementia of the Alzheimer type (DAT), HIV-related dementia syndrome, and the on-off syndrome of Parkin
Furio MM; Weidle PJ; Wordell CJ; Liu HH; Department of Pharmacy, Thomas Jefferson University Hospital,; Philadelphia, PA 19107.
We reviewed the records of 49 patients who had 55 episodes of Pneumocystis carinii pneumonia (PCP) from January 1984 to January 1987. Thirty-three patients had acquired immunodeficiency syndrome (AIDS), with the risk groups being homosexual/bisexual practices (26), hemophilia (6), and blood transfusion (1). Fourteen p
Proc Natl Acad Sci U S A. 1988 Dec;85(23):9214-8. Unique Identifier : AIDSLINE MED/89057906
Carini C; Margolick J; Yodoi J; Ishizaka K; Subdepartment of Immunology, School of Medicine, Johns Hopkins; University, Baltimore, MD.
Peripheral blood mononuclear cells of 10 out of 26 patients with human immunodeficiency virus type 1 (HIV-1) released IgE-binding factors, as determined by two independent assays. The formation of the factors by the mononuclear cells was enhanced by incubation of the cells with homologous IgE. In the presence of IgE,
Proc Natl Acad Sci U S A. 1988 Dec;85(23):9229-33. Unique Identifier : AIDSLINE MED/89057909
Karpas A; Fleet GW; Dwek RA; Petursson S; Namgoong SK; Ramsden NG; Jacob GS; Rademacher TW; Clinical School, Department of Hematological Medicine, University; of Cambridge, United Kingdom.
Recent data suggest that aminosugar derivatives which inhibit glycoprotein processing have potential anti-human immunodeficiency virus (HIV) activity. These inhibitory effects may be due to disruption of cell fusion and subsequent cell-cell transmission of the acquired immunodeficiency syndrome (AIDS) virus. Free viru
Proc Natl Acad Sci U S A. 1988 Dec;85(23):9248-52. Unique Identifier : AIDSLINE MED/89057913
Montefiori DC; Robinson WE Jr; Mitchell WM; Department of Pathology, Vanderbilt University, School of; Medicine, Nashville, TN 37232.
Human immunodeficiency virus type 1 (HIV-1), the retrovirus responsible for acquired immunodeficiency syndrome (AIDS), contains two heavily glycosylated envelope proteins, gp120 and gp41, which mediate attachment of virions to glycosylated cell surface receptor molecules (CD4 antigens) and appear to be responsible for
Raviglione MC; Dinan WA; Pablos-Mendez A; Palagiano A; Sabatini MT; Department of Medicine, Cabrini Medical Center, New York, NY; 10003.
The combination of pyrimethamine and sulfadoxine (Fansidar) has been reported to cause severe skin reactions including erythema multiforme, Stevens-Johnson syndrome, and toxic epidermal necrolysis. Recently, this drug combination has been used for prophylaxis of Pneumocystis carinii pneumonia in patients with the acqu
AIDS Res Hum Retroviruses. 1988 Oct;4(5):319-29. Unique Identifier : AIDSLINE MED/89062028
Kalyanaraman VS; Pal R; Gallo RC; Sarngadharan MG; Department of Cell Biology, Bionetics Research, Inc. Rockville,; MD 20850.
A clone of the HUT78 cell line, chronically infected with the HIV-1 isolate HTLV-III451, has been demonstrated to secrete unprocessed HIV-1 envelope precursor protein gp160 as well as mature gp120. Further, when grown in serum-free defined medium these cells released approximately five times the amount of virus compar
Fuchs D; Banekovich M; Hausen A; Hutterer J; Reibnegger G; Werner ER; Gschnait FD; Dierich MP; Wachter H; Institute of Medical Chemistry and Biochemistry, University of; Innsbruck, Austria.
We measured neopterin, a biochemical indicator for the activation of cell-mediated immune reactions, in urines from 105 individuals at risk of infection with human immunodeficiency virus-1 (HIV-1), 83 of whom were seropositive for antibody to HIV-1. We compared absolute numbers of T-cell subsets (CD4+ helper/inducer T
Dianzani U; Pileri A; Bianchi A; Camponi A; Tamponi G; Massaia M; Department of Medicine and Experimental Oncology, University of; Turin, Italy.
Subset distribution, ecto-5 nucleotidase (5 NT) activity, and the generation of allospecific cytotoxic T lymphocytes (CTL) were investigated in peripheral blood T lymphocytes from 39 hemophilia A patients divided into three groups: group A and group B (HIV-patients with CD4:CD8 ratio less than 1 and greater than 1 res
Locksley RM; Crowe S; Sadick MD; Heinzel FP; Gardner KD Jr; McGrath MS; Mills J; Department of Medicine, University of California San Francisco; Medical Center 94143.
Infection of monocyte-macrophages with human immunodeficiency virus may be central to the pathogenesis of the acquired immunodeficiency syndrome. The ability of infected macrophages to prime T cells through IL-1 production was investigated in vitro. Purified human monocytes maintained in suspension culture were infect
Liu MA; Liu T; Endocrine Unit, Massachusetts General Hospital, Boston.
We have previously demonstrated that recombinant soluble CD4 protein (rsT4) blocks both HIV-1 infection of CD4 bearing lymphocytes and syncytium formation in vitro. (Recombinant soluble CD4 is designated by rsT4). Hence, we suggested the use of rsT4 in therapy for AIDS or the prevention of HIV-1 infection in individua
J Immunol. 1988 Dec 15;141(12):4181-6. Unique Identifier : AIDSLINE MED/89067489
Schnittman SM; Lane HC; Roth J; Burrows A; Folks TM; Kehrl JH; Koenig S; Berman P; Fauci AS; Laboratory of Immunoregulation, National Institute of Allergy and; Infectious Diseases, Bethesda, MD 20892.
There is evidence that the initial interaction between HIV-1 and the host that is essential for infection is the specific binding of the viral envelope glycoprotein, gp120, to the CD4 molecule found on certain T cells and monocytes. Most individuals infected with HIV develop antibodies against the gp120 protein. Altho
Salmon P; Olivier R; Riviere Y; Brisson E; Gluckman JC; Kieny MP; Montagnier L; Klatzmann D; Laboratoire de Biologie et Genetique des Deficits; Immunitaires, Faculte de Medecine Pitie-Salpetriere, Paris,; France.
Using mAbs and genomic probe to the CD4 molecule, the HIV receptor, we demonstrated that HIV replication induces the disappearance of its functional receptor from the cell surface by two distinct mechanisms. First, after being expressed onto the cell surface, HIV envelope gp110 will complex CD4, efficiently masking th
Chieco-Bianchi L; Saggioro D; Del Mistro A; Montaldo A; Majone F; Levis AG; Institute of Oncology, University of Padova, Italy.
Experiments were carried out to investigate whether the human T-lymphotropic virus type I (HTLV-I), alone or in combination with a chemical mutagen such as mitomycin C (MMC), has the capacity to damage host chromosomes. Cord-blood T lymphocytes (CBL) were infected by co-cultivation with lethally irradiated HTLV-I-prod
Wien Med Wochenschr. 1988 Oct 31;138(19-20):480-2. Unique Identifier : AIDSLINE MED/89073820
Kunz C; Institut fur Virologie, Universitat Wien.
AIDS is a notifiable disease in Austria . In 1983, the first 6 cases were recorded. Thereafter, the numbers doubled approximately each year, reaching 182 on May 30, 1988. On the same date, a total of 2433 persons were found to be infected. The highest rates of AIDS patients and ser
Adv Exp Med Biol. 1988;239:217-21. Unique Identifier : AIDSLINE MED/89074382
Lee JC; Badger AM; Johnson WJ; Department of Immunology & Antiinfective Therapy, Smith Kline &; French Laboratories, Philadelphia, PA 19101.
A HTLV-1 transformed T cell line has been demonstrated to constitutively produce and secrete a lymphokine with macrophage activating properties. This lymphokine was biologically and biochemically distinct from interferon gamma, the interleukins, the colony stimulating factors and lymphotoxin. In vitro treatment of hum
Am J Pathol. 1988 Dec;133(3):648-59. Unique Identifier : AIDSLINE MED/89074729
Goldstein J; Braverman M; Salafia C; Buckley P; Ben-Gurion University of the Negev, Faculty of the Health; Sciences, Beer-Sheba, Israel.
The antigenic phenotype of human villous stromal macrophages (M phi s) from first and third trimester placentas was analyzed using a large number of monoclonal antibodies (MAbs) to monocyte (Mo)/M phi-associated cell membrane determinants. The purpose of this study was to investigate M phi phenotypic heterogeneity to
Salim YS; Faber V; Wiik A; Andersen PL; Hoier-Madsen M; Mouritsen S; Department of Infectious Diseases, University of Copenhagen,; Denmark.
Patients suffering from AIDS tend to have symptoms that resemble those encountered in adrenocortical insufficiency. Serum sodium concentrations and blood pressure values were monitored and found to be subnormal, despite the fact that renin activity and aldosterone levels were either normal or elevated. We report the p
Rabson AB; Koenig S; Daugherty DF; Gendelman HE; Laboratory of Molecular Microbiology, National Institute of; Allergy and Infectious Disease, Bethesda, MD 20892.
Molecular studies of the pathogenesis of human immunodeficiency virus (HIV) infections have proceeded rapidly following the molecular cloning and nucleotide sequence analysis of the HIV genome. Correlation of biochemical and functional studies of HIV-infected cells with the HIV nucleotide sequence has allowed the iden
Retroviruses code for a virus-specific protease which is essential for polyprotein processing and viral infectivity. The human immune deficiency virus-1 protease is an aspartic protease of 9 kDa which was synthesized by recombinant DNA technology and arises by autocatalytic processing from a polyprotein precursor whic
Donovan RM; Cohen SH; Peterson WR; Bolton V; Jordan GW; Carlson JR; Vanden Brink KM; Goldstein E; Bush C; Department of Internal Medicine, University of California, Davis; 95616.
Rapid and sensitive nonradioactive methods to detect human immunodeficiency virus (HIV)-infected cells are needed in clinical medicine. We developed an in situ hybridization test using 2-acetylaminofluorene (AAF)-labeled HIV DNA as a hybridization probe. Hybridized probe was detected using rabbit anti-AAF antibody, fo
Ammann AJ; Genetech, Inc., South San Francisco, CA 94080.
Pediatric acquired immunodeficiency syndrome (PAIDS) results from infection with human immunodeficiency virus (HIV). The majority of infants with AIDS are infected in utero. In most instances, mothers are infected from intravenous drug abuse or bisexual partners. Infected individuals, both mothers and infants, may be
Grady C; Allergy and Infectious Diseases Nursing Service, National; Institutes of Health, Bethesda, Maryland.
HIV infection is a global problem, with the largest number of cases occurring in the United States . HIV affects men, women, and children with varying frequency in different parts of the world. The spectrum of HIV infection and its consequences is broad. HIV, a retrovirus, is responsibl
Hendricksen C; Department of Infectious Diseases, Johns Hopkins Hospital,; Baltimore, Maryland.
Because of the increasing number of AIDS cases diagnosed every day, the need for an effective antiviral therapy is evident. As AIDS patients become more numerous, nurses will discover that they need to know more about antiviral therapy for AIDS. The work that is being done in the AIDS Clinical Trials Unit exemplifies
Rosenthal Y; Haneiwich S; National Institutes of Health, Bethesda, Maryland.
This chapter has provided an overview of the nursing process from the initial assessment to discharge planning in the care of the adult AIDS patient. The psychosocial aspects have not been addressed since they are discussed in the article by Govoni. The emotional support required by the patient may be as great as the
Ward-Wimmer D; Children's Hospital National Medical Center, Washington, DC.
Infection with HIV is producing a new population of chronically and terminally ill children. This chapter deals with issues to help in the understanding of both the physical realities and the experience of families who live in the shadow of AIDS.
Bennett J; Gay Men's Health Crisis, New York, New York.
Responding to AIDS as a chronic, multisystem disease means emphasizing quality of life as the chief goal throughout its course. By mobilizing and supporting the strengths of the individual and his/her social network, the homecare nurse allows the person with AIDS or ARC to focus his/her energy on being well, not the d
Govoni LA; National Institutes of Health, Bethesda, Maryland.
The psychosocial issues of homosexual men with AIDS and their significant others pose a profound nursing care challenge. The nurse s knowledge and sensitivity to these issues is necessary to meet the challenge of this patient group. Unique aspects of AIDS such as youth, stigma, contagiousness and sexual transmission,
Henderson DJ; United States Food and Drug Administration, Bethesda, Maryland.
The risk for occupational transmission of HIV-1 in the health setting is extremely small. Current data from a number of prospective studies of health care workers sustaining adverse exposure to blood or other body fluids from patients infected with HIV-1 demonstrate that the rate for transmission of infection followin
Reisman EC; Seafarers' Addiction Rehabilitation Center, Valley Lee, Maryland.
Nurses are morally obligated to give quality nursing care to all HIV-infected individuals that respects their dignity as individuals without regard to their differences in values and lifestyle, the nature of their illness, or their own contribution to infection. This obligation is defended by the principle of benefice
McMahon KM; Division of Nursing, Memorial Sloan-Kettering Cancer Center, New; York, New York.
Historically, registered professional nurses have responded to the health care needs of the community in a variety of roles. Practitioner, educator, administrator, consultant, or researcher--health promotion and prevention have served as an integral part of nursing practice. With the emergence this decade of HIV infec
Bolle JL; National Cancer Institute, Bethesda, Maryland.
AIDS, with the number of cases and death toll increasing every day, puts caregivers at great risk for burnout. In order to prevent the detrimental consequences of burnout and to meet the challenge of this catastrophic illness, strategies need to be implemented. This overview not only explores the sources of stress rel
Nunez EA; INSERM U 224, Faculte et Hopital X.-Bichat, Paris, France.
The overall data presented in this review show that cortisol and free fatty acids, in particular long-chain polyunsaturated fatty acids, each have immunoinhibitory properties on lymphoblastic transformation of certain T lymphocytes. This effect is enhanced when the two factors are associated. These data could explain
Westhoff-Bleck M; Galanski M; Abt. Diagnostische Radiologie I, Med. Hochschule Hannover.
In patients suffering from an immunosuppressive state pneumonia is a common manifestation of infection. In these patients the radiological appearance of pneumonia is influenced by the still existing immunocompetent reaction and not by the germ itself. Basic defense mechanisms in known underlying disease, clinical cond
Galanski M; Westhoff-Bleck M; Abt. Diagnostische Radiologie I, Med. Hochschule Hannover.
Advances in the area of tumour therapy and transplantation medicine as well as increasing numbers of immunodeficiency syndromes have resulted into growing importance of opportunistic infections. The radiological diagnosis and differential diagnosis become more difficult due to the broad spectrum of possible pathogenic
Sekiguchi S; Ikeda H; Kato T; Maeda R; Fukai K; Hokkaido Red Cross Blood Center, Sapporo, Japan.
An automated pretransfusion testing system was applied to HIV antibody screening by a gelatin particle agglutination (HIV-PA) test. The test conditions for the test, such as diluent, plate shape, and incubation time, were applicable not only for the HIV-PA test but also for other routine tests, including those for hep
The respective roles of high pressure and high tidal volume to promote high airway pressure pulmonary edema are unclear. Positive end-expiratory pressure (PEEP) was shown to reduce lung water content in this type of edema, but its possible effects on cellular lesions were not documented. We compared the consequences o
Moskovitz BL; Clinical Research Division, Rhone-Poulenc Pharmaceuticals,; Princeton, New Jersey 08543.
An open-label, multicenter clinical trial assessed the tolerance of HPA-23 (ammonium-21-tungsto-9-antimoniate) in patients with acquired immune deficiency syndrome. Sixty-nine patients were sequentially assigned to receive 0.25, 0.5, 1.0, or 2.0 mg of HPA-23 per kg intravenously 5 days per week for 8 weeks. HPA-23 was
Afessa B; Green WR; Williams WA; Hagler NG; Gumbs RV; Hackney RL; Frederick WR; Department of Medicine, Howard University Medical School,; Washington, DC 20060.
A case of generalized Pneumocystis carinii infection presented as hilar and mediastinal lymphadenopathy and was complicated by spontaneous pneumothorax. Extrapulmonary P carinii infection in patients with acquired immunodeficiency syndrome is rare, and pneumothorax is even rarer. The purpose of this report is to call
Kennedy RC; Chanh TC; Allan JS; Dreesman GR; Eichberg JW; Cauda R; Kanda P; Department of Virology and Immunology, Southwest Foundation for; Biomedical Research, San Antonio, Texas 78284.
Fischer PA; Enzensberger W; Zentrum der Neurologie und Neurochirurgie, Johann Wolfgang; Goethe-Universitat Frankfurt, F.R.G.
The neurologic sequelae of human immunodeficiency virus (HIV) infection may be divided into primary (= HIV-induced) and secondary (= opportunistic infections and malignancies) manifestations. Our experience with 215 HIV-infected patients indicates that major clinical symptoms are due to a few, albeit important, neurol
Rayfield M; De Cock K; Heyward W; Goldstein L; Krebs J; Kwok S; Lee S; McCormick J; Moreau JM; Odehouri K; et al; AIDS Program, Centers for Disease Control, Atlanta, Georgia; 30333.
Sera from persons seroreactive to both human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2), by whole-virus (VEIA) enzyme immunoassays (EIAs) for each virus, were selected from a seroprevalence study of 944 persons in Abidjan, Cote d Ivoire , West Africa, in 1987. The
Ellis M; Gupta S; Galant S; Hakim S; VandeVen C; Toy C; Cairo MS; Department of Medicine, School of Medicine, University of; California, Irvine.
We measured the neutrophil function of 6 patients with AIDS and Kaposi s sarcoma (KS); 22 patients with AIDS-related complex (ARC); and 28 healthy, heterosexual controls. Neutrophils from patients with ARC showed significantly less chemotaxis (P less than or equal to .025) than did those from patients with AIDS and KS
Lifson AR; Rutherford GW; Jaffe HW; San Francisco Department of Public Health, California 94103.
Although much is known about the natural history of HIV infection, many issues remain unresolved and require additional study. At least four major questions require further investigation. (1) Current data suggest that most HIV-infected persons will eventually develop AIDS. The proportion of all infected persons who wi
Defalque D; Menu Y; Matheron S; Girard PM; Nahum H; Service de Radiologie, Hopital Beaujon, Clichy.
AIDS-related Kaposi sarcoma is most often multicentric and extensive. Hepatic involvement is unusual and asymptomatic. An anicteric cholestasis may exist. Ultrasonography shows a pedicular echogenic infiltration and a heterogeneous parenchyma with small hyperechoic nodules. On CT, these hypodense lesions are related t
N Engl J Med. 1988 Dec 15;319(24):1573-8. Unique Identifier : AIDSLINE MED/89070614
Schmitt FA; Bigley JW; McKinnis R; Logue PE; Evans RW; Drucker JL; Department of Neurology, University of Kentucky Medical Center,; Lexington 40536-0084.
Two hundred eighty-one patients with the acquired immunodeficiency syndrome (AIDS) or advanced AIDS-related complex were enrolled in a double-blind, placebo-controlled trial of the efficacy and safety of orally administered zidovudine (azidothymidine or A
Gonzales MF; Davis RL; Department of Pathology (Neuropathology Unit), University of; California, San Francisco 94143-0506.
The nervous system is involved in the acquired immunodeficiency syndrome (AIDS) by infections and infestations, by neoplasms, and by several diseases of uncertain pathogenesis. The most common pathological abnormalities are the changes associated with the HIV agent itself, the HIV subacute encephalitis ; the most spe
Ficarra G; Berson AM; Silverman S Jr; Quivey JM; Lozada-Nur F; Sooy DD; Migliorati CA; Division of Oral Medicine, University of California, San; Francisco.
Since our first description and profile of patients with Kaposi s sarcoma (KS) in 1984, the relative rate of KS in patients with the acquired immunodeficiency syndrome has dropped from 34% to 20%. However, the absolute number is increasing. The pathogenesis of KS is still obscure, and its interaction with the human im
Darbas H; Pelous C; Jean A; Boyer G; Jean-Pierre H; Donadio D; Navarro M; Laboratoire de Bacteriologie-Virologie-Serologie, Montpellier,; France.
We report a case of C. jejuni chronic diarrhea in a homosexual man with AIDS. The antibiotic susceptibility of the bacteria was about normal for the species. Investigating specific immunity, we observed the presence of anti-C. jejuni IgG and the absence of anti-C. jejuni IgA. These findings concord with the hypothesis
Cooper ER; Pelton SI; LeMay M; Division of Infectious Diseases, Boston University School of; Medicine, Massachusetts.
Cases of AIDS in children have been described since 1982. Diagnosis is more complex in children than in adults owing to the more varied clinical presentations and the difficulty in interpretation of laboratory tests. Our current understanding of HIV infection in children is reviewed, as well as the controversies regar
Chasnoff IJ; Northwestern University Medical School, Chicago, Illinois.
With the increasing incidence of substance abuse in the United States , there has been a concomitant increase in the number of women becoming pregnant while using substances of abuse. The infant delivered to a drug-addicted woman is at risk for problems of growth and development as well
Proc Natl Acad Sci U S A. 1988 Dec;85(24):9733-7. Unique Identifier : AIDSLINE MED/89071770
Wano Y; Feinberg M; Hosking JB; Bogerd H; Greene WC; Howard Hughes Medical Institute, Duke University Medical Center,; Durham, NC 27710.
Stable expression of the 40-kDa transactivator protein (Tax) from the type I human T-cell leukemia virus (HTLV-I) in Jurkat T cells leads to the activation and sustained expression of certain cellular genes that are transiently induced during normal T-cell growth. Cellular genes induced by Tax include those encoding t
Recent discoveries in the field of virus receptors have revolutionized our concepts of viral pathogenesis. The lysis of cells resulting from virus infection or immune recognition of infected cells is seen as merely one facet of a spectrum of pathogenic mechanisms which may be subtle and complex. This is particularly r
South Med J. 1988 Dec;81(12):1493-5. Unique Identifier : AIDSLINE MED/89072851
Hilton CW; Harrington PT; Prasad C; Svec F; Section of Endocrinology, Louisiana State University Medical; Center, New Orleans 70112.
Patients with the acquired immunodeficiency syndrome (AIDS) often have signs and symptoms suggestive of adrenal insufficiency. Reports in the literature suggest that adrenal insufficiency may be relatively common in patients with AIDS based on the finding of destructive adrenal lesions in a large number of the patient
Rubin RH; Tolkoff-Rubin NE; Dialysis-Transplant Unit, Massachusetts General Hospital, Boston; 02114.
The risk of opportunistic infection in the renal transplant patient is due to an interaction between two major factors: the epidemiologic exposures (particularly within the hospital environment) and the net state of immunosuppression. The net state of immunosuppression is determined by the nature, dose, and duration o
Nyunoya H; Akagi T; Ogura T; Maeda S; Shimotohno K; Virology Division, National Cancer Center Research Institute,; Tokyo, Japan.
Human T-cell leukemia virus type I (HTLV-I) encodes a trans-activator protein p40x which positively regulates transcription of the viral RNA as well as interleukin-2 and its receptor genes. We placed a cDNA coding for p40x in baculovirus Bombyx mori nuclear polyhedrosis virus (BmNPV) expression vectors. Infection of B
Hizi A; Hughes SH; Sackler School of Medicine, Tel Aviv University, Ramat Aviv,; Israel.
We have constructed expression plasmids containing the genes for the MuLV and the HIV integration proteins. When introduced into Escherichia coli, these plasmids cause the production of proteins of the expected molecular weight (43K for MuLV, 31K for HIV). The wild-type MuLV coding region induces the synthesis of larg
The new, revised CDC case definition of AIDS (1) specifies precisely, which laboratory results and which diseases may indicate HIV-infection. The indicator diseases are divided into those with HIV-positive and HIV-not positive laboratory findings. The latter group is subdivided into diseases diagnosed definitely and d
In this study the structures of the AIDS-virus are presented, furthermore the cross-reactivity of HIV-1 and HIV-2 is described as well as the known genes of both viruses. The mechanism of cell infection, its kinetics and the special role of activated T-cells and macrophages in this process are outlined. This interrela
Wien Med Wochenschr. 1988 Oct 31;138(19-20):492-9. Unique Identifier : AIDSLINE MED/89073823
Gschnait F; Schmidt BL; Dermatologischen Abteilung, Krankenhauses der Stadt Wien-Lainz.
AIDS serology is of worldwide importance for the diagnosis of HIV-infection and AIDS, for conducting epidemiological studies, for the control of blood donations and blood products and for the determination of infectivity and prognosis in AIDS patients. In future serological methods may be of importance for the managem
Wien Med Wochenschr. 1988 Oct 31;138(19-20):500-3. Unique Identifier : AIDSLINE MED/89073824
Konrad K; I. Universitats-Hautklinik Wien.
An increasing number of skin and mucous membrane biopsies from AIDS patients is submitted for histopathologic examination. The dermatopathologist must be aware about the wide spectrum of AIDS-associated non-specific cutaneous manifestations, of cutaneous infections and of skin neoplasms. The histological criteria esse
The vast number of symptoms, diseases and findings, which can be observed in the course of HIV-infection, required an arrangement in a systematic order. The classification system for adults of the Centers for Disease Control (CDC) distinguishes between 4 groups and some subgroups. Group I includes acute infection, gro
Wien Med Wochenschr. 1988 Oct 31;138(19-20):508-10, 514-6. Unique Identifier : AIDSLINE MED/89073826
Civatte J; Janier M; Clinique des Maladies Cutanees, Hopital Saint-Louis, Paris.
In HIV-infections, skin manifestations are manifold and are conditioned mainly by the immunodeficiency. Kaposi s sarcoma, oral hairy leucoplakia and candidiasis of the esophagus are of diagnostic significance as same as a severe course of opportunistic infections e.g. herpes simplex, herpes zooster, cryptococcosis, de
Wien Med Wochenschr. 1988 Oct 31;138(19-20):517-20. Unique Identifier : AIDSLINE MED/89073827
Zielinski C; II. Medizinischen Universitatsklinik-Wien.
The acquired immune deficiency syndrome (AIDS) is characterized by a multitude of clinical complications consisting of mainly opportunistic infections and malignancies. Particularly often encountered and life-threatening conditions are therefore due to infections of the respiratory tract (pneumonias caused by pneumocy
1% of registered AIDS cases are children, 80% have been perinatally infected. Special diagnostic criteria have to be applied for infants. Intrauterine infection can produce a specific malformation syndrome. Chronic pulmonary illness can be caused by pulmonary lymphoid hyperplasia and-less frequently-by Pneumocystis ca
Wien Med Wochenschr. 1988 Oct 31;138(19-20):531-4. Unique Identifier : AIDSLINE MED/89073830
Mose JR; Hygiene-Institut, Universitat Graz.
Following an explanation of the most important routes of infection, there are general recommendations for protection against HIV-infection. Part 2 discusses AIDS risks and prophylaxis in the hospitals and in the offices of physicians. This discussion includes both, general aspects and specific medical questions. Both
The development of an AIDS vaccine represents a major challenge for medical research. Efforts are undertaken for the production of appropriate immunogens in sufficient quantity and purity, especially by the use of recombinant DNA technology. Unfortunately, all immunization experiments using chimpanzees were negative s
Am J Pathol. 1988 Dec;133(3):516-24. Unique Identifier : AIDSLINE MED/89074714
Schuurman HJ; Krone WJ; Broekhuizen R; Goudsmit J; Department of Internal Medicine, University Hospital, Utrecht,; The Netherlands.
The presence of proteins (p17 and p24 core proteins, gp41 envelope protein) and mRNA (gag/pol and env gene segments) of human immunodeficiency virus type-1 (HIV-1) was analyzed on frozen tissue sections of lymph nodes from HIV-1 infected individuals. Thirty-one lymph nodes were categorized in the stages of follicle hy
Central Nervous System (CNS) involvement, whether primary by the Human Immunodeficiency Virus--HIV--itself, or secondary (toxoplasmosis or lymphoma) is remarkably frequent in AIDS, in 40 to 70% of cases, depending upon the author. In order to study the natural history of this illness, a cohort of 25 asymptomatic serop
Miller EJ; Lee CA; Karayiannis P; Hamilton-Dutoit SJ; Dick R; Thomas HC; Kernoff PB; Academic Department of Haematology, Royal Free Hospital School of; Medicine, London.
Liver biopsy specimens previously taken from 16 haemophilic patients with chronic non-A, non-B hepatitis were reviewed. The degree of fibrosis correlated with serum procollagen III peptide (sPIIIP) concentrations, measured both at the time of biopsy and 4.25 years later. Two patients with extremely high sPIIIP concent
Chiodi F; Norkrans G; Hagberg L; Sonnerborg A; Gaines H; Froland S; Fenyo EM; Norrby E; Vandvik B; Department of Virology, Karolinska Institute, Stockholm, Sweden.
Sera and CSF from 29 patients in early and late stages of HIV infection were analysed for intrathecal antibody production. Elevated CSF-IgG indices indicating intrathecal IgG synthesis were demonstrated in 9 patients while 4 of 18 patients tested had oligoclonal IgG bands in the CSF. Analysis of HIV-specific antibodie
Parquet A; Boneu B; Bosser C; Cazenave JP; Dirat G; Gazengel G; Grunebaum L; Sultan Y; Verroust F; Wiesel ML; Centre Regional de Transfusion Sanguine, Lille, France.
The efficiency of heat treatment procedures of factor VIII and factor IX concentrates, prepared from voluntary, non-paid donors by three French Blood Transfusion Centres, on the inactivation of HIV and non-A, non-B hepatitis (NANB) viruses was assessed. Some 43 patients (26 haemophilia A, 17 haemophilia B) were follow
Mattsson L; Aberg B; Weiland O; Sellman M; Davilen J; Department of Infectious Diseases, Karolinska Institute,; Roslagstull Hospital, Stockholm, Sweden.
In 1979 the incidence of non-A, non-B (NANB) posttransfusion hepatitis (PTH) in Stockholm was 19%. After the discovery of HIV the Swedish Board of Health put forward new regulations for blood donations and since 1985 has enforced testing for HIV on all blood units. To find out if these measures have had any impact on
Scharff O; Foder B; Thastrup O; Hofmann B; Moller J; Ryder LP; Jacobsen KD; Langhoff E; Dickmeiss E; Christensen SB; et al; Department of Clinical Physiology and Nuclear Medicine,; University Hospital, Copenhagen, Denmark.
The tumor-promoting sesquiterpene lactone, thapsigargin, induced a dose-dependent increase of the cytoplasmic Ca2+ concentration ([ Ca2+]i) in human lymphocytes from a resting level between 100 and 150 nM up to about 1 microM. Half-maximum response was found at about 1 nM of thapsigargin, full response at 100 nM. The
Furlini G; Re MC; Bandini G; Albertazzi L; La Placa M; Institute of Microbiology, University of Bologna, St. Orsola; Hospital, Italy.
An antibody response to human immunodeficiency virus (HIV) is described in a young woman with T-lymphoblastic leukemia, who received a bone marrow transplant from a donor retrospectively found to be HIV positive.
Kashiwagi S; Hayashi J; Ikematsu H; Noguchi A; Ikeda K; Kishida K; Shirakawa M; Takenaka A; Mori R; First Department of Internal Medicine, Faculty of Medicine,; Kyushu University, Fukuoka.
To determine when the hemophiliacs in Fukuoka prefecture, Japan , first became positive for antibodies, we tested human immunodeficiency virus (HIV) antibodies on serum samples obtained from 1976-1987 stored at -30 C. Fifteen out of 64 hemophilia A patients (23.4%), five out of 11 he
Hewlett D Jr; Duncanson FP; Jagadha V; Lieberman J; Lenox TH; Wormser GP; Department of Medicine, Our Lady of Mercy Medical Center, Bronx,; NY 10466.
Generalized lymphadenopathy in intravenous drug abusers (IVDAs) at risk for AIDS has not been well studied. We have retrospectively analyzed the results of lymph node biopsies obtained from 27 patients referred to the Infectious Diseases Service for evaluation of generalized lymphadenopathy and suspected AIDS during a
De Raeve L; Song M; Van Maldergem L; Department of Dermatology, Hopital Saint-Pierre, Free University; of Brussels, Belgium.
A maculopapular rash is reported in a girl with AIDS and Pneumocystis carinii pneumonia treated with co-trimoxazole. AIDS patients seem to be at increased risk of adverse drug reactions.
Immunol Lett. 1988 Sep;19(1):7-13. Unique Identifier : AIDSLINE MED/89053439
Cianciolo GJ; Bogerd H; Snyderman R; Department of Medicine, Duke University Medical Center, Durham,; North Carolina 27710.
Immunosuppression frequently accompanies infections with the human retroviruses HTLV-1 and HIV. Previous studies have shown that UV-inactivated and detergent-disrupted preparations of either virus can produce immune dysfunction in vitro although the active component of such preparations has not yet been identified. We
Ramirez G; Wiener D; Murtha DG; Brueggemeyer CD; Rowlands DT Jr; Department of Internal Medicine, James A. Haley VA Hospital,; Tampa, Florida.
A study of peripheral blood mononuclear cell phenotyping and HIV testing was performed in 39 chronic hemodialysis patients. The following abnormalities were found in comparison to a control population: 1) a lower percentage of lymphocytes in the white blood cell differential count, 2) a lower percentage of total T cel
JAMA. 1988 Dec 23-30;260(24):3635-7. Unique Identifier : AIDSLINE MED/89056004
Odaka N; Eldred L; Cohn S; Munoz A; Fields HA; Fox R; Solomon R; Kaslow R; Polk BF; Johns Hopkins University School of Hygiene and Public Health,; Baltimore, Md 21205.
A randomized, double-blind clinical trial of plasma-derived and DNA recombinant hepatitis B virus vaccines was conducted in 186 homosexual men. Nine months after the immunization series (three doses) began, the seroconversion rate in the plasma vaccine group was 88% (68/77); this was significantly higher than the 74%
Am J Cardiol. 1988 Dec 1;62(17):1311-3. Unique Identifier : AIDSLINE MED/89060121
Monsuez JJ; Kinney EL; Vittecoq D; Kitzis M; Rozenbaum W; d'Agay MF; Wolff M; Marche C; Janier M; Gorin I; et al; Department of Hematology, Hopital Saint-Louis, Paris, France.
Sienko DG; Anda RF; McGee HB; Weber JA; Remington PL; Hall WN; Gunn RA; Division of Disease Surveillance, Michigan Department of Public; Health, Lansing 48909.
To assess the implementation of hepatitis B virus (HBV) vaccination programs for hospital workers, we mailed questionnaires to all 229 licensed Michigan hospitals. The response rate was 96% (221/229); of these, 68% (150/221) had vaccination programs. Although multiple hospital characteristics were associated with the
Miedema F; Petit AJ; Terpstra FG; Schattenkerk JK; de Wolf F; Al BJ; Roos M; Lange JM; Danner SA; Goudsmit J; et al; Central Laboratory of the Netherlands Red Cross Blood Transfusion; Service, University of Amsterdam, The Netherlands.
To investigate the effect of persistent HIV infection on the immune system, we studied leukocyte functions in 14 asymptomatic homosexual men (CDC group II/III) who were at least two years seropositive, but who still had normal numbers of circulating CD4+ T cells. Compared with age-matched heterosexual men and HIV-nega
Dalh Christensen L; Svenson M; Nygaard P; Andersen V; Faber V; Department of Infectious Deseases, Rigshospitalet, Copenhagen,; Denmark.
The levels of purine enzyme activities were studied in 10 patients with acquired immunodeficiency syndrome (AIDS) or AIDS related complex (ARC) and in 6 healthy individuals with antibodies against human immunodeficiency virus (HIV). All AIDS/ARC patients studied had ecto-5 nucleotidase (ecto-5 NUC) activity in B lymph
Hartelius H; Gaub J; Ingemann Jensen L; Jensen J; Faber V; Department of Diagnostic Radiology, Rigshospitalet, University of; Copenhagen, Denmark.
Computed tomography of the chest was performed on 42 occasions as part of the diagnostic work-up in 26 homosexual men with, or suspected of the acquired immunodeficiency syndrome (AIDS). In 17 cases both the chest radiographs and the lung scans were abnormal, and bronchoscopy and/or lung biopsy established an etiologi
Johnson M; Caiazzo T; Molina JM; Donahue R; Groopman J; Department of Medicine, New England Deaconess Hospital, Harvard; Medical School, Boston, Mass. 02215.
We have studied the in vitro effects of nucleoside inhibitors of reverse transcriptase on bone marrow myeloid and erythroid progenitor development. Both 3 -azido-3 -deoxythymidine ( AZT ) and 2 ,3 -dideoxycytidine (DDC) potently inhibited in vitro haema
Linde A; Hammarstrom L; Smith CI; Department of Virology, National Bacteriological Laboratory,; Stockholm, Sweden.
Immunoglobulin G subclass titers to three herpesviruses (herpes simplex; HSV; cytomegalovirus , CMV ; varicella zoster virus, VZV) were examined in patients with common variable immunodeficiency (CVI) before and after immunoglo
Jones KA; Luciw PA; Duchange N; Molecular Biology and Virology Laboratory, Salk Institute, La; Jolla, California 92037.
Promoter-proximal downstream regions of the human immunodeficiency viruses (HIV-1 and HIV-2) mediate the action of the viral transcription activator protein, Tat. We demonstrate here that the downstream domain of each virus interacts with two RNA polymerase II transcription factors. One of these, CTF/NF I, is a multif
Niedobitek G; Finn T; Herbst H; Gerdes J; Grillner L; Landqvist M; Wirgart BZ; Stein H; Department of Pathology, Freie Universitat Berlin, Federal; Republic of Germany.
In situ hybridisation, immunohistochemistry, and morphological analysis for the detection of cytomegalovirus ( CMV ) were compared in routinely processed tissue sections from a patient with acquired immune deficiency syndrome (
Valk PE; Budinger TF; Levin VA; Silver P; Gutin PH; Doyle WK; Donner Laboratory, University of California, Berkeley.
Positron emission tomography (PET) with rubidium-82 (82Rb) and fluorine-18-fluorodeoxyglucose (18F-FDG) was used to diagnose active tumor recurrence and to differentiate this from radiation injury after interstitial irradiation of malignant gliomas. Patients were studied when they presented with radiological or clinic
Spinner A; Sutjipto S; California Primate Research Center, University of California,; Davis 95616.
Simian Acquired Immunodeficiency Syndrome (SAIDS) is an important disease in captive primates in the United States associated with an unusually high mortality rate. Isolation of a type D retrovirus as the cause of SAIDS was rapidly followed by the development of an enzyme linked immuno
Opportunistic pneumonias are a life-threatening complication in patients with AIDS. Early diagnosis and therapy is necessary to improve prognosis. This study was designed to assess the value of 67Ga scintigraphy in the primary detection and follow-up of these special pneumonias. 67Ga scintigraphy was performed in 40 p
McArthur JH; Palenicek JG; Bowersox LL; Department of Epidemiology, Johns Hopkins University, Baltimore,; Maryland.
In conclusion, there are a number of neurological manifestations of HIV infection, affecting both the central and peripheral nervous systems. Involvement of the CNS may occur very early in the course of infection and manifest itself as an acute aseptic meningitis. HIV encephalopathy is currently the most commonly diag
Proc Natl Acad Sci U S A. 1988 Dec;85(23):8825-9. Unique Identifier : AIDSLINE MED/89057831
Lenardo MJ; Kuang A; Gifford A; Baltimore D; Whitehead Institute for Biomedical Research, Cambridge, MA 02142.
The activity of the enhancer for the kappa immunoglobulin light chain gene critically depends on the presence in the nucleus of the NF-kappa B protein. We purified NF-kappa B over 50,000-fold and identified two protein species, 42 and 44 kDa, that could be eluted and renatured from a sodium dodecyl sulfate/polyacrylam
Hofmann B; Nielsen PB; Odum N; Gerstoft J; Platz P; Ryder LP; Poulsen AG; Mathiesen L; Dickmeiss E; Norrild B; et al; Department of Clinical Immunology, State University Hospital,; Copenhagen, Denmark.
The titers of IgG and IgA to Pneumocystis carinii in 36 AIDS patients did not differ significantly from those in 31 controls. Only 2/15 patients (13%) with P. carinii pneumonia (PCP) had titers of IgM antibodies greater than or equal to 5, which is significantly less frequent than in 32 controls (62%) and in 21 AIDS p
Gotzsche PC; Bygbjerg IC; Olesen B; Moller LH; Salim YS; Faber V; Department of Infectious Diseases, Rigshospitalet, Copenhagen,; Denmark.
To examine the therapeutic consequences of diagnostic tests for AIDS-related infections, case records from 33 deceased AIDS patients were reviewed; 23 were autopsied. Determination of serum antibody titres was not important. In particular, there was no relation between titres and isolation of
Ann Intern Med. 1988 Dec 15;109(12):963-9. Unique Identifier : AIDSLINE MED/89060797
Bloom JN; Palestine AG; National Eye Institute, Bethesda, Maryland.
Immunosuppressed patients are at risk for developing cytomegalovirus retinitis. This disorder is the most common cause of vision loss in patients with the acquired immunodeficiency syndrome (AIDS). Cytomegalovirus retinitis is probably the result of hematogenous spread of the virus
Narasimhan S; Lee JW; Cheung RK; Gelfand EW; Schachter H; Division of Biochemistry Research, Hospital for Sick Children,; Toronto, Ont., Canada.
beta-1,4-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase III (GlcNAc-T III) catalyzes the incorporation of a bisecting N-acetylglucosamine (GlcNAc) residue in beta 1-4 linkage to the beta-linked mannose of the core of asparagine linked-protein bound oligosaccharides (N-glycans). The activity of GlcNAc-T
AIDS Res Hum Retroviruses. 1988 Oct;4(5):331-42. Unique Identifier : AIDSLINE MED/89062029
Durda PJ; Leece B; Jenoski A; Rabin H; Fisher A; Wong-Staal F; E.I. duPont de Nemours & Co., Medical Products Department, N.; Billerica, MA 01862.
We have used short synthetic peptides, 12 and 13 amino acids in length, conjugated to carrier proteins to develop monoclonal antibodies (MAb) to the envelope glycoprotein of 120 (kD) (gp120) and the 3 open reading frame protein (3-orf) of the human immunodeficiency virus type 1 (HIV-1). The peptides employed were cho
AIDS Res Hum Retroviruses. 1988 Oct;4(5):369-79. Unique Identifier : AIDSLINE MED/89062033
Moore JP; Jarrett RF; MRC AIDS Research Laboratory, University of Glasgow, Scotland.
We have used a panel of polyclonal and monoclonal antibodies against gp120 and gp160, the envelope glycoproteins of human immunodeficiency virus type 1, to create rapid, simple, and sensitive twin-site sandwich ELISA specific for gp120 and gp160 or for gp160 alone. These assays can detect 500 COS cells in a population
AIDS Res Hum Retroviruses. 1988 Oct;4(5):381-91. Unique Identifier : AIDSLINE MED/89062034
Lubon H; Ghazal P; Nelson JA; Hennighausen L; Laboratory of Biochemistry and Metabolism, National Institutes of; Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892.
The binding of nuclear proteins and the functional activity of the HIV-LTR enhancer repeats in different cell lines (Jurkat, CEM, H9, U937, Raji, B cells, T47D, HeLa, 293, and HepG2 cells) was investigated in vitro. Five distinct complexes formed with the enhancer repeat have been identified by an electrophoretic mobi
Dtsch Med Wochenschr. 1988 Dec 9;113(49):1920-2. Unique Identifier : AIDSLINE MED/89064540
Just G; Simader R; Helm EB; Stille W; Falk S; Stutte HJ; Hubner K; Zentrum der Inneren Medizin, Universitat Frankfurt/Main.
A 32-year-old homosexual with AIDS, who until 1985 was a frequent traveller to South America and mediterranean countries, had recurrent bouts of fever, splenomegaly, arthralgias as well as granulocytopenia and anaemia. Liver and bone-marrow punctures were performed to exclude malignant lymphoma and (or) a mycobacteria
Walker CM; Steimer KS; Rosenthal KL; Levy JA; Cancer Research Institute, University of California, School of; Medicine, San Francisco 94143.
Two T helper cell clones recognizing the gp 120 envelope protein of HIV were generated from the peripheral blood of a healthy seropositive individual. These cells were type specific as they proliferated and produced IL 2 when stimulated by an epitope in the amino-terminal half of gp 120 of HIVSF2, but not by a similar
Shibata D; Martin WJ; Appleman MD; Causey DM; Leedom JM; Arnheim N; Department of Pathology, Los Angeles County-University of; Southern California Medical Center 90033.
Detection of cytomegalovirus ( CMV ) DNA can be facilitated by the polymerase chain reaction (PCR), an in vitro gene amplification technique. Twenty-eight CMV tissue culture isolates were examined by amplification of two separa
Zhang JY; Martin LN; Watson EA; Montelaro RC; West M; Epstein L; Murphey-Corb M; Delta Regional Primate Research Center, Tulane University,; Covington, Louisiana 70433.
Infection of the rhesus macaque (Macaca mulatta) with simian immunodeficiency virus (SIV) induces a disease similar to AIDS. We compared SIV-specific antibody and antigenemia with the progression of disease in monkeys experimentally infected with SIV/Delta isolates that varied in pathogenicity. Western blot, immunopre
One of the unique features of retroviruses is their ability to integrate their genetic information in the genomes of their host cells, including the germ line, and to persist there as so-called proviruses. Proviruses which are contained in the germ line of a given species and are inherited from generation to generatio
Yamamoto JK; Pedersen NC; Ho EW; Okuda T; Theilen GH; Department of Medicine, School of Veterinary Medicine, University; of California, Davis.
A feline T-lymphotrophic lentvirus (FTLV) has recently been isolated from a domestic cat free of feline leukemia virus (FeLV). This virus is distinct from FeLV (an oncornavirus), although they share a common denominator, namely, the ability to cause immunosuppression and induce lymphadenopathy and anemia. Their differ
Tremblay M; Fitz-Gibbon L; Wainberg MA; Lady Davis Institute for Medical Research, Sir Mortimer B.; Davis-Jewish General Hospital, Montreal, Quebec, Canada.
Over a period of six months, we have followed a total of six different EBV-transformed B cell lines, each of which has been infected by the human immunodeficiency virus (HIV-1). The results indicate that all of these lines were initially able to produce progeny HIV-1, but that over time three of them ceased to produce
Bentwich Z; Burstein R; Berner Y; Gotlieb-Stematsky T; Vonsover A; Handzel Z; R. Ben-Ari Institute of Clinical Immunology, Kaplan Medical; Center, Rehovot, Israel.
Israel is still a low incidence country for AIDS and thus the temporal relationships between various cofactors and HIV infection can be more easily determined. We have studied a cohort of 243 asymptomatic male homosexuals (MHS) during the last 4 years. At the beginning of the study
Presse Med. 1988 Nov 12;17(40):2129-33. Unique Identifier : AIDSLINE MED/89071649
Henin D; Hauw JJ; Laboratoire de Neuropathologie R. Escourolle, Hopital de la; Salpetriere, Paris.
The nervous system may be affected at any stage in the course of HIV-1 infection. Acute or subacute inflammatory demyelinating polyradiculoneuropathies occur often early and improve spontaneously. Distal symmetrical axonal, predominantly sensory, painful polyneuropathies occur in the late stages of the disease. Microv
Proc Natl Acad Sci U S A. 1988 Dec;85(24):9580-4. Unique Identifier : AIDSLINE MED/89071740
Willey RL; Bonifacino JS; Potts BJ; Martin MA; Klausner RD; Laboratory of Molecular Microbiology, National Institute of; Allergy and Infectious Diseases, Bethesda, MD 20892.
The synthesis and processing of the human immunodeficiency virus 1 (HIV-1) envelope precursor glycoprotein gp 160 was studied in an infected CD4+ lymphocytic cell line. Surprisingly, only a small percentage (5-15%) of gp160 is cleaved to produce the mature gp120 component. Intracellular sorting results in the transfer
Proc Natl Acad Sci U S A. 1988 Dec;85(24):9753-7. Unique Identifier : AIDSLINE MED/89071774
Arya SK; Gallo RC; Laboratory of Tumor Cell Biology, National Cancer Institute,; Bethesda, MD 20892.
The long terminal repeats (LTRs) of the human immunodeficiency virus type 2 (HIV-2) and a related simian immunodeficiency virus (SIVmac) contain cis-acting positive regulatory elements upstream and the major transactivator gene (tat) response element and a possible negative regulatory element downstream of the transcr
Wien Med Wochenschr. 1988 Oct 31;138(19-20):524-30. Unique Identifier : AIDSLINE MED/89073829
Wolff K; Stingl G; I. Universitats-Hautklinik Wien.
Therapeutic strategies in the management of AIDS should aim at an inhibition of the replication and spread of HIV; the reconstitution of immune functions; an effective chemotherapy of opportunistic infections and tumors; and the prevention of new opportunistic infections. At present, these goals can be only partially
Lancet. 1988 Nov 26;2(8622):1214-7. Unique Identifier : AIDSLINE MED/89056429
de Wit R; Schattenkerk JK; Boucher CA; Bakker PJ; Veenhof KH; Danner SA; Department of Medicine, Academic Medical Centre, Amsterdam, The; Netherlands.
The effectiveness and antiretroviral activities of interferon-alpha in AIDS-related Kaposi s sarcoma was assessed in a non-randomised, phase-II clinical trial. 28 patients were treated with high-dose (27-36 MU) human recombinant interferon-alpha 2a subcutaneously every day for 8 weeks. In patients with stable disease
Lancet. 1988 Nov 26;2(8622):1218-22. Unique Identifier : AIDSLINE MED/89056430
Lane HC; Kovacs JA; Feinberg J; Herpin B; Davey V; Walker R; Deyton L; Metcalf JA; Baseler M; Salzman N; et al; Laboratory of Immunoregulation and Treatment Branch, National; Institute of Allergy and Infectious Diseases, Bethesda, Maryland.
21 patients with AIDS and Kaposi s sarcoma were enrolled in an open therapeutic trial to determine the in vivo anti-retroviral activity of recombinant interferon-alpha (IFN-alpha). 8 (38%) showed a complete or partial anti-tumour response. The mean pretreatment CD4 count for the responders was 399 cells/microliter vs
Lancet. 1988 Dec 3;2(8623):1283-6. Unique Identifier : AIDSLINE MED/89056485
O'Doherty MJ; Thomas S; Page C; Barlow D; Bradbeer C; Nunan TO; Bateman NT; Department of Nuclear Medicine, St. Thomas' Hospital, London.
The study compared the pulmonary deposition of nebulised pentamidine when inhaled by way of different nebuliser systems by nine human-immunodeficiency-virus-positive patients with a history of previous Pneumocystis carinii pneumonia. Pentamidine, 50 mg or 300 mg, mixed with technetium-99m-labelled human serum albumin
Lancet. 1988 Dec 3;2(8623):1297-302. Unique Identifier : AIDSLINE MED/89056493
Dournon E; Matheron S; Rozenbaum W; Gharakhanian S; Michon C; Girard PM; Perronne C; Salmon D; De Truchis P; Leport C; et al; Claude Bernard Hospital, Paris, France.
Zidovudine ( AZT ) is of some benefit for selected patients with AIDS-related complex (ARC) or AIDS treated for up to 24 weeks. The activity and toxicity of oral AZT, 200 mg 4-hourly when possible, was evaluated in 365 consecutive patients with ARC (80)
Gan To Kagaku Ryoho. 1988 Dec;15(12):3169-88. Unique Identifier : AIDSLINE MED/89061095
Shimoyama M; Hematology-Oncology and Clinical Cancer Chemotherapy Division,; National Cancer Center Hospital.
Great progress has been made in clinical research on non-Hodgkin s lymphoma during the last 15 years. Surface marker and DNA analyses of immunoglobulin and T-cell receptor genes are essential for new classification of the disease according to the cellular origin of tumor cells. Thi
Goto T; Harada S; Yamamoto N; Nakai M; Department of Microbiology, Osaka Medical College, Japan.
The ultrastructural features of early events in human immunodeficiency virus (HIV) infection of HTLV-I-carrying MT-2 lymphocytes were investigated by electron microscopy. Within 10 min after virus inoculation at 37 degrees C, the virus entered the cell in two ways; (1) the virus attached to the lymphocyte membrane and
Wainberg MA; Dascal A; Blain N; Fitz-Gibbon L; Boulerice F; Numazaki K; Tremblay M; Lady Davis Institute for Medical Research, Sir Mortimer B. Davis,; Jewis General Hospital, Montreal, Quebec, Canada.
The effect of cyclosporine A (CyA) on the ability of the human immunodeficiency virus type 1 (HIV-1) to infect the H-9 T-cell leukemic line, as well as interleukin-2 ( IL-2 )-grown human peripheral blood-derived lymphocytes, has been studied. Pretreatment of H-9 cells an
Lancet. 1988 Dec 17;2(8625):1389-91. Unique Identifier : AIDSLINE MED/89069975
Evans LA; Moreau J; Odehouri K; Seto D; Thomson-Honnebier G; Legg H; Barboza A; Cheng-Mayer C; Levy JA; Department of Medicine, University of California School of; Medicine, San Francisco 94143.
Two distinct human immunodeficiency viruses, HIV-1SF480 and HIV-2UC2 were isolated simultaneously from the blood of an Ivory Coast patient with AIDS. The HIV subtypes were segregated by their differential ability to infect established human cell lines and by the cell surface e
Lancet. 1988 Dec 17;2(8625):1414-5. Unique Identifier : AIDSLINE MED/89069985
Kesten S; Rebuck AS; Division of Respiratory Medicine, Toronto Western Hospital,; Canada.
10 cm H2O of nasal continuous positive airway pressure (CPAP) was applied in nine subjects with Pneumocystis carinii pneumonia and the acquired immunodeficiency syndrome, all of whom had presented with bilateral pulmonary infiltrates and hypoxaemia. The procedure was tolerated well by eight patients and none of the ni
Wien Med Wochenschr. 1988 Oct 31;138(19-20):487-92. Unique Identifier : AIDSLINE MED/89073822
Stingl G; Abteilung fur Immunbiologie der Haut, I.; Universitats-Hautklinik Wien.
Although, in the course of HIV-1-infection, the functional capacities of virtually all immune cells are greatly impaired, only CD4+ cells (antigen-presenting cells, helper T cells) are directly infected by the virus. CD4+ T cells are involved, to a greater or lesser degree, in the induction of virtually all immunologi
Cancer Res. 1989 Jan 1;49(1):226-8. Unique Identifier : AIDSLINE MED/89063231
Tokudome S; Tokunaga O; Shimamoto Y; Miyamoto Y; Sumida I; Kikuchi M; Takeshita M; Ikeda T; Fujiwara K; Yoshihara M; et al; Department of Community Health Science, Saga Medical School,; Japan.
Using a population-based cancer registry, we tabulated 69 definite adult T-cell leukemia/lymphoma cases (36 males and 33 females) and 2.20 expected cases (0.95 for males and 1.25 for females) diagnosed from 1981 to 1983 in Saga, Japan . The number of human T-lymphotropic virus type I
Bohnlein S; Hauber J; Cullen BR; Howard Hughes Medical Institute, Duke University Medical Center,; Durham, North Carolina 27710.
Retrovirus mRNAs are normally polyadenylated within the proviral 3 long terminal repeat (LTR). The site of retrovirus transcript polyadenylation is flanked 3 by an LTR-specific sequence termed the U5 region, but the role of U5 in the determination of polyadenylation efficiency has not been addressed. We have used si
JAMA. 1989 Jan 13;261(2):258-62. Unique Identifier : AIDSLINE MED/89069010
Curtis JL; Crummey FC; Baker SN; Foster RE; Khanyile CS; Wilkins R; Department of Psychiatry and Substance Abuse Services, Harlem; Hospital Center, New York, NY 10037.
At least one third of patients enrolled in a methadone maintenance treatment program are willing to comply voluntarily with screening for and counseling about human immunodeficiency virus (HIV). A questionnaire about knowledge, attitudes, and behavior concerning acquired immunodeficiency syndrome was answered anonymou
Oldham SA; Castillo M; Jacobson FL; Mones JM; Saldana MJ; Department of Diagnostic Radiology, University of Miami School of; Medicine, Jackson Memorial Medical Center, FL 33136.
The authors reviewed chest radiographs of 16 patients with biopsy-proved lymphocytic interstitial pneumonia (LIP) who also had acquired immunodeficiency syndrome (AIDS) or AIDS-related complex (ARC). Radiographs revealed fine reticular or reticulonodular infiltrates in the pulmonary interstitium in five patients, coar
Patterson RB; Kempczinski RF; Department of Surgery, University of Cincinnati Medical Center,; Ohio 45267-0558.
Although the risk of infection with hepatitis or HIV remains low, and the effectiveness of steps to reduce even this small risk is difficult to assess, the sequelae of the infection with either virus are often devastating. We described herein the use of a sterile Petri dish to inspect vascular anastomoses during arter
Am J Public Health. 1989 Jan;79(1):81-2. Unique Identifier : AIDSLINE MED/89074960
Mascola L; Lieb L; Iwakoshi KA; McAllister D; Siminowski T; Giles M; Run G; Fannin SL; Strantz IH; Los Angeles County Department of Health Service.
To estimate the seroprevalence and investigate risk behaviors for HIV (human immunodeficiency virus) infection in intravenous drug users in Los Angeles County, a stratified, random sample of 790 clients, enrolled in either methadone maintenance or detoxification programs, were studied. Thirteen study participants (1.8
Bhalla K; Birkhofer M; Grant S; Graham G; Department of Medicine, Columbia University, College of; Physicians and Surgeons, New York, New York.
Administration of 3 -azido-3 -deoxythymidine ( AZT ) to patients with acquired immunodeficiency syndrome (AIDS) causes significant anemia and neutropenia. The bone marrow cytotoxicity of AZT has been attributed to deoxyribonucleotide pool perturbations
Loeb DD; Hutchison CA 3d; Edgell MH; Farmerie WG; Swanstrom R; Department of Microbiology and Immunology, University of North; Carolina, Chapel Hill 27599.
Processing of the retroviral gag and pol gene products is mediated by a viral protease. Bacterial expression systems have been developed which permit genetic analysis of the human immunodeficiency virus type 1 protease as measured by cleavage of the pol protein precursor. Deletion analysis of the pol reading frame loc
Payami H; Department of Medical Genetics, Oregon Health Sciences; University, Portland 97201.
The traditional method for calculating risk in prospective and retrospective studies is based on the assumption that the study population is homogeneous. Risk is therefore estimated as an overall average for the entire population, when in fact some individuals may be at high risk and others at little or no risk. This
Ruben S; Perkins A; Purcell R; Joung K; Sia R; Burghoff R; Haseltine WA; Rosen CA; Department of Molecular Oncology, Roche Institute of Molecular; Biology, Nutley, New Jersey.
Site-directed mutagenesis was used to identify functional domains present within the human immunodeficiency virus (HIV) tat protein. Transient cotransfection experiments showed that derivatives of tat protein with amino acid substitutions either at the amino-terminal end or at cysteine residue 22, 37, 27, or 25 were n
Dewar RL; Natarajan V; Vasudevachari MB; Salzman NP; Division of Molecular Virology and Immunology, Georgetown; University School of Medicine, Washington, D.C. 20007.
A recombinant adenovirus was constructed by inserting the human immunodeficiency virus type 1 (HIV-1) envelope gene downstream from the early region 3 (E3) promoter of adenovirus type 5 (Ad5), replacing the coding sequences of E3. The recombinant virus replicated as efficiently as the parent virus in all cell lines te
Poss ML; Mullins JI; Hoover EA; Department of Pathology, Colorado State University, Fort Collins; 80523.
The envelope glycoprotein (gp70) of a molecularly cloned, replication-defective feline leukemia virus (FeLV-FAIDS clone 61C) carries determinants for induction of fatal immunodeficiency disease, whereas the gp70 of its companion replication-competent, probably parent virus (clone 61E) does not. Immunoprecipitation ana
Hinnant K; Schwartz A; Rotterdam H; Rudski C; Department of Pathology, New York University Medical Center, NY.
We report two cases of acalculous cholecystitis due to infection with cytomegalovirus ( CMV ) and cryptosporidium. Both involved homosexual men who presented with right upper quadrant pain and elevations of serum alkaline phosp
Am J Cardiol. 1989 Jan 1;63(1):86-9. Unique Identifier : AIDSLINE MED/89074604
Levy WS; Simon GL; Rios JC; Ross AM; Department of Medicine, George Washington University, Washington,; DC 20037.
The prevalence of cardiac abnormalities in the spectrum of human immunodeficiency virus (HIV) infection is unknown. Sixty consecutive HIV-infected patients were studied using echocardiograms, electrocardiograms (50 patients) and ambulatory electrocardiographic monitoring (43 patients). Group A (25 patients) were serop
EMBO J. 1988 Aug;7(8):2547-53. Unique Identifier : AIDSLINE MED/89052670
Le Grice SF; Mills J; Mous J; Central Research Units, F. Hoffmann-La Roche & Co. Ltd., Basel,; Switzerland.
Replacement of the putative active site Asp residue of cloned HIV-1 protease with Ala yields a molecule incapable of autocatalytic processing. Similarly, protease/reverse transcriptase and protease/reverse transcriptase/endonuclease polyproteins containing the same mutation accumulate as enzymatically inert polyprotei
The sequences of a set of 63 peptides of demonstrated T immunogenicity have been analyzed and compared with two different randomly generated sets of sequences. This study indicates a statistically significant tendency of T immunogenic peptides to be constituted of clusters of rare tetrapeptides, as evaluated from the
Nature. 1988 Dec 1;336(6198):484-7. Unique Identifier : AIDSLINE MED/89057146
Nixon DF; Townsend AR; Elvin JG; Rizza CR; Gallwey J; McMichael AJ; Institute of Molecular Medicine, John Radcliffe Hospital, Oxford,; UK.
Current candidate vaccines fail to protect primates against challenge with human immunodeficiency virus (HIV) in the presence of antibody responses; this underlines the importance of studying cell-mediated immunity to HIV and identifying specific epitopes that stimulate cytotoxic T lymphocytes (CTL). Using a recombina
Proc Natl Acad Sci U S A. 1988 Dec;85(23):9273-7. Unique Identifier : AIDSLINE MED/89057918
Mizukami T; Fuerst TR; Berger EA; Moss B; Laboratory of Viral Diseases, National Institutes of Health,; Bethesda, MD 20892.
The binding region for human immunodeficiency virus (HIV) and epitopes for a panel of HIV-blocking anti-CD4 monoclonal antibodies of the CD4 molecule were defined by using in vitro site-directed mutagenesis. Codons for two amino acid residues (Ser-Arg) were inserted at selected positions within the region encoding the
AIDS Res Hum Retroviruses. 1988 Oct;4(5):359-68. Unique Identifier : AIDSLINE MED/89062032
Tsai CC; Follis KE; Benveniste RE; Regional Primate Research Center, University of Washington,; Seattle 98195.
The simian acquired immunodeficiency syndrome (SAIDS) in macaques at the Washington Regional Primate Research Center is associated with a type D retrovirus known as SAIDS-D/WA. We tested the ability of 3 -azido-3 -deoxythymidine ( AZT ), 2 ,3 -dideoxycy
AIDS Res Hum Retroviruses. 1988 Oct;4(5):393-8. Unique Identifier : AIDSLINE MED/89062035
Lori F; Scovassi AI; Zella D; Achilli G; Cattaneo E; Casoli C; Bertazzoni U; Instituto di Genetica Biochimica ed Evoluzionistica del CNR,; Pavia, Italy.
The reverse transcriptase of HIV-1 (AIDS virus) is characterized by the presence of two highly immunogenic proteins of 66 and 51 kD known to be enzymatically active as a complex p66/51. Using an activity gel procedure that allows identification of catalytic polypeptides in situ after PAGE in denaturing conditions, we
Lazar AP; Lazar P; Department of Dermatology, Northwestern University Medical; School, Chicago, Illinois.
We report a case of hyperpigmentation due to bleomycin treatment in a patient with acquired immune deficiency syndrome (AIDS). Although this type of hyperpigmentation has been previously seen in patients with cancer who are receiving bleomycin, this is, to our knowledge, the first reported case of bleomycin-induced hy
In spite of much ongoing experimentation, the consensus view is that a vaccine will be difficult to achieve. New strategies of chemo- and immunotherapy may bear more rapid results.
Papsidero LD; Sheu M; Ruscetti FW; Cellular Products, Inc., Buffalo, New York 14202.
Monoclonal antibodies (MAbs) to human immunodeficiency virus type 1 were produced. Two antibodies reacted with the 17-kilodalton core protein (p17) of the virus and with its polyprotein precursor. To various degrees, each MAb neutralized infection by the cell-free virus. With a series of sequential overlapping hexapep
Schweiz Med Wochenschr. 1988 Oct 22;118(42):1546-50. Unique Identifier : AIDSLINE MED/89072666
Guetty-Torello M; Beris P; Exquis B; Departement de medecine, Hopital cantonal universitaire de; Geneve.
Severe thrombocytopenia has been diagnosed in HIV seropositive patients independently of the clinical stage of disease. In view of its immunologic origin, attempts have been made to treat this condition with drugs which have proved effective in the treatment of autoimmune thrombocytopenia, though with little or no ben
In: Monagle, John F.; Thomasma, David C., eds. Medical Ethics: A Guide for Health Professionals. Rockville, Md.: Aspen Publishers, 1988 :443-459. Unique Identifier : AIDSLINE KIE/26544
New York Supplement, 2d Series. 1986 Feb 11 (date of decision);502:325-342. Unique Identifier : AIDSLINE KIE/26586
Two local school boards and a concerned parent brought an action before the New York Supreme Court for an order prohibiting New York City education and health officials from admitting an unidentified child with AIDS to any public school within the city attended by students without AIDS. The Court held that the defend
In: Callahan, Daniel; Dunstan, G.R., eds. Biomedical Ethics: An Anglo-American Dialogue. New York: New York Academy of Sciences, 1988 :154-156. (Annals of the New York Academy of Sciences; v. 530) Unique Identifier : AIDSLINE KIE/26766
In: Callahan, Daniel; Dunstan, G.R., eds. Biomedical Ethics: An Anglo-American Dialogue. New York: New York Academy of Sciences, 1988 :157-158. (Annals of the New York Academy of Sciences; v. 530) Unique Identifier : AIDSLINE KIE/26767
In: Callahan, Daniel; Dunstan, G.R., eds. Biomedical Ethics: An Anglo-American Dialogue. New York: New York Academy of Sciences, 1988 :159-162. (Annals of the New York Academy of Sciences; v. 530) Unique Identifier : AIDSLINE KIE/26768
In: Callahan, Daniel; Dunstan, G.R., eds. Biomedical Ethics: An Anglo-American Dialogue. New York: New York Academy of Sciences, 1988 :167-171. (Annals of the New York Academy of Sciences; v. 530) Unique Identifier : AIDSLINE KIE/26770
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