Important note: Information in this article was accurate in 1989. The state of the art may have changed since the publication date.
ACID-LABILE HUMAN INTERFERON ALPHA
The Interferon System. A Current Review to 1987. Baron S et al, eds. The University of Texas Medical Branch Series in Biomedical Science, Austin, TX, University of Texas Press, p. 31-40, 1987.. Unique Identifier : AIDSLINE ICDB/89650479 Chadha KC; Ikossi MG; Roswell Park Memorial Inst., Buffalo, NY 14263
Abstract:
Of all types of interferons (IFNs) described to date, the acid-labile IFN-alpha has been the most prominently associated with disorders presumed to be the result of immune disregulation; thus, acid-labile IFN-alpha has been detected in sera of patients who have systemic lupus erythematosus, rheumatoid arthritis, Down's syndrome, AIDS, or Kaposi's sarcoma (in homosexual men). Available evidence indicates that this IFN probably represents a normal physiologic component of the IFN system. The authors describe their own studies on acid-labile IFN produced by normal leukocytes and by subset polymorphonuclear (PMN) cells in response to Sendai virus, using the abbreviation HuIFN-alpha to refer to IFN produced by leukocytes according to Cantell's procedure and containing only acid-stable alpha IFNs, and the abbreviation HuIFN-alpha(l) to refer to IFN produced by leukocytes or PMN cells according to the procedure of Chadha and Sulkowski and containing both acid-labile and acid-stable alpha IFNs. Results of the studies are presented under the following section headings: alpha IFN synthesis by peripheral blood leukocytes, synthesis of HuIFN-alpha(l) by PMN cells, physicochemical and biological properties of HuIFN-alpha(l), association of HLA-B35 phenotype with HuIFN-alpha(l) synthesis, and heterogeneity of acid-labile IFNs. The authors conclude that acid-labile IFN is alpha type as determined by its antigenicity and cross-species antiviral activity. From the very limited studies carried out so far, it seemed that the HuIFN-alpha(l) is more potent than the HuIFN-alpha in its antiviral and antiproliferative activities. The HuIFN-alpha(l) is heterogeneous and there seems to be some relationship between HLA-B35 antigen and the ability of WBC to preferentially synthesize this type of IFN. To better understand the role of HuIFN-alpha(l) in immune disregulation, it is considered to be important to elucidate the nature of control of its production, its effect on cellular and humoral immunity, and its modulating effect on other biological responses. (22 Refs)
Keywords: Animal Antiviral Agents Cell Division/DRUG EFFECTS Cells, Cultured Human Hydrogen-Ion Concentration HLA-B Antigens/GENETICS Interferon Inducers Interferon Type I/ANALYSIS/*BIOSYNTHESIS/PHARMACOLOGY Leukocytes/*METABOLISM/MICROBIOLOGY Mice Neutrophils/METABOLISM/MICROBIOLOGY Parainfluenza Virus Type 1 Phenotype MONOGRAPH REVIEW REVIEW, TUTORIAL
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Important note: Information in this article was accurate in 1989. The state of the art may have changed since the publication date.
