Progressive multifocal leukoencephalopathy of the posterior fossa in an AIDS patient: clinical, radiographic and evoked potential findings. NLM AIDSLINE Important note: Information in this article was accurate in 1989. The state of the art may have changed since the publication date.

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Progressive multifocal leukoencephalopathy of the posterior fossa in an AIDS patient: clinical, radiographic and evoked potential findings.

Eur Neurol. 1988;28(5):258-61. Unique Identifier : AIDSLINE MED/89137173
Lipton RB; Krupp L; Horoupian D; Hershkovitz S; Arezzo JC; Kurtzberg D; Department of Neurology, Albert Einstein College of Medicine,; Bronx, N.Y.

Abstract: A 39-year-old intravenous drug user presented with dysarthria and a syndrome of the left cerebellar hemisphere. While in hospital, he developed progressive brainstem findings. Repeated CT scans revealed a lucency in the white matter of the left cerebellar hemisphere. Brainstem auditory and short-latency somatosensory evoked potentials provided evidence of brainstem dysfunction without corresponding lesions on CT. Biopsy of the cerebellum established the diagnosis of progressive multifocal leukoencephalopathy (PML) and the acquired immunodeficiency syndrome (AIDS). Postmortem examination revealed brainstem lesions appropriate to the evoked potential findings and a radiographically inapparent lesion in the right internal capsule. Based on this case and a review of the literature we conclude that: (1) PML occurs with significant prevalence in AIDS patients and may involve the posterior fossa; (2) the diagnosis of posterior fossa PML is suggested by certain clinical and radiographic criteria and may be confirmed by brain biopsy; (3) evoked potentials may be abnormal in PML and can reveal functional abnormalities of white matter without apparent CT abnormalities.
Keywords: Acquired Immunodeficiency Syndrome/*COMPLICATIONS/PHYSIOPATHOLOGY Adult Brain Stem/PATHOLOGY/*PHYSIOPATHOLOGY Case Report Evoked Potentials, Auditory Evoked Potentials, Somatosensory Human Leukoencephalopathy, Progressive Multifocal/*ETIOLOGY/ PHYSIOPATHOLOGY/RADIOGRAPHY Male Tomography, X-Ray Computed JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/KWDcomplications/physiopathologyadultbrainstem/pathology/KWDphysiopathologycasereportevokedpotentials,auditoryevokedpotentials,somatosensoryhumanleukoencephalopathy,progressivemultifocal/KWDetiology/physiopathology/radiographymaletomography,x-raycomputedjournalarticle
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Copyright © 1989 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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