Neurological features in AIDS patients: studies on cerebrospinal fluid. NLM AIDSLINE Important note: Information in this article was accurate in 1989. The state of the art may have changed since the publication date.

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Neurological features in AIDS patients: studies on cerebrospinal fluid.

Ital J Neurol Sci. 1988 Dec;9(6):567-72. Unique Identifier : AIDSLINE MED/89138982
Ortona L; Tamburrini E; Antinori A; Ventura G; Istituto di Clinica delle Malattie Infettive, Universita; Cattolica del Sacro Cuore, Roma.

Abstract: The relationship between cerebrospinal fluid (CSF) markers of HIV infection and the spectrum of neurological manifestations were studied in 15 AIDS patients (13 with and 2 without confirmed neurological disorders). We demonstrated the presence of intrathecally synthesized anti-HIV antibodies. Antibodies to HIV envelope proteins were present in all patients but those to HIV core proteins in 9/13 cases only. HIV antigen and HIV p24 antigen were present in 6/14 and 4/12 cases respectively. HIV was not isolated from 6 samples of CSF. We have demonstrated that CSF markers of HIV infection were present in all AIDS patients, with or without neurological manifestations. Moreover HIV p24 antigen seems to be a very reliable marker of HIV infection.
Keywords: Acquired Immunodeficiency Syndrome/*CEREBROSPINAL FLUID/ COMPLICATIONS/IMMUNOLOGY Adult Aged Brain Diseases/CEREBROSPINAL FLUID/*ETIOLOGY/IMMUNOLOGY Female Human HIV Antibodies/*CEREBROSPINAL FLUID HIV Antigens/*CEREBROSPINAL FLUID Male Middle Age JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/KWDcerebrospinalfluid/complications/immunologyadultagedbraindiseases/cerebrospinalfluid/KWDetiology/immunologyfemalehumanhivantibodies/KWDcerebrospinalfluidhivantigens/KWDcerebrospinalfluidmalemiddleagejournalarticle
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M8960583

Copyright © 1989 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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