Group specific component (Gc) and HIV diseases. NLM AIDSLINE Important note: Information in this article was accurate in 1989. The state of the art may have changed since the publication date.

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Group specific component (Gc) and HIV diseases.

Dis Markers. 1988 Oct-Dec;6(4):269-74. Unique Identifier : AIDSLINE MED/89169121
Rosberger DF; Werner PA; Steinman R; Stevens CE; Friedman-Kien AE; Rubinstein P; Galbraith RM; Department of Microbiology, Medical University of South Carolina,; Charleston 29425.

Abstract: A previous report suggested a relationship between particular phenotypes of group specific component (Gc), and susceptibility or resistance to HIV infection, whereas other recent investigations failed to corroborate this finding. The present study demonstrated that Gc allele frequencies in white homosexual men corresponded to those expected, regardless of HIV serology and related disease. Assignment of phenotype was not influenced by Gc complexing secondary to tissue damage, or the process of infection per se. However, Gc allele frequencies in black patients with AIDS were significantly different from those in black control subjects, suggesting that the previously observed results might be in part explicable on the basis of gene admixture in ethnically mixed populations.
Keywords: Acquired Immunodeficiency Syndrome/BLOOD/*GENETICS Alleles Caucasoid Race/GENETICS Comparative Study Gene Frequency Genetic Markers/BLOOD Human Male Negroid Race/GENETICS Phenotype Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. Vitamin D-Binding Protein/BLOOD/*GENETICS JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/blood/KWDgeneticsallelescaucasoidrace/geneticscomparativestudygenefrequencygeneticmarkers/bloodhumanmalenegroidrace/geneticsphenotypesupport,non-uKWDsKWDgov'tsupport,uKWDsKWDgov't,pKWDhKWDsKWDvitamind-bindingprotein/blood/KWDgeneticsjournalarticle
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Copyright © 1989 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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