PERIPHERAL NERVOUS SYSTEM DYSFUNCTION IN ACQUIRED IMMUNODEFICIENCY SYNDROME

Important note: Information in this article was accurate in 1989. The state of the art may have changed since the publication date.

PERIPHERAL NERVOUS SYSTEM DYSFUNCTION IN ACQUIRED IMMUNODEFICIENCY SYNDROME

AIDS and the Nervous System. Rosenblum ML et al, eds. New York, Raven Press, p. 65-78, 1988.. Unique Identifier : AIDSLINE ICDB/89648463
Miller RG; Kiprov DD; Parry G; Bredesen DE; Dept. of Clinical Neurology and Neuromuscular Res., Children's; Hosp., 3700 California Street, Room OP613, San Francisco, CA; 94118

Abstract: Patients (pts) with AIDS or AIDS-related complex (ARC) are susceptible to a wide variety of peripheral nervous system (PNS) complications, including cranial neuropathies. In about one-third of the pts, these complications are caused by secondary pathogens, such as varicella zoster virus or other herpes viruses. Nearly all of the remaining pts have an immune-mediated peripheral neuropathy manifested by one of three clinical syndromes: distal symmetric peripheral neuropathy (DSPN), chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), or mononeuropathy multiplex (MM). Symptoms of peripheral neuropathy, abnormal physical findings, including case reports of DSPN, CIDP and MM, electrophysiological studies, laboratory features, immunological aspects, natural history, and treatment of PNS lesions are discussed, along with differential diagnosis and etiology of cranial neuropathies. Dysfunction of the PNS has been reported in 9-16% of pts with AIDS. Pts with ARC and persons who are apparently healthy but have serological evidence of infection with HIV may also have dysfunction. The incidence in these latter two groups appears to be lower than in AIDS pts. The severity of symptoms varies greatly and the reported incidence is likely to be an underestimation. (24 Refs)

Keywords: Acquired Immunodeficiency Syndrome/COMPLICATIONS/*PHYSIOPATHOLOGY Adult AIDS-Related Complex/PHYSIOPATHOLOGY Case Report Cranial Nerve Diseases/ETIOLOGY/PHYSIOPATHOLOGY Cranial Nerves/PHYSIOPATHOLOGY Human Male Motor Neurons/PHYSIOLOGY Opportunistic Infections/ETIOLOGY/PHYSIOPATHOLOGY Peripheral Nerves/PHYSIOPATHOLOGY Peripheral Nervous System Diseases/ETIOLOGY/*PHYSIOPATHOLOGY Polyradiculoneuritis/ETIOLOGY/PHYSIOPATHOLOGY MONOGRAPH REVIEW, TUTORIAL REVIEW

890130
M8910545

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Boehringer Ingelheim, Bridgestone/Firestone Charitable Trust, Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1989. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1989. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .