NEOPLASMS OF THE CENTRAL NERVOUS SYSTEM IN ACQUIRED IMMUNODEFICIENCY SYNDROME NLM AIDSLINE Important note: Information in this article was accurate in 1989. The state of the art may have changed since the publication date.

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NEOPLASMS OF THE CENTRAL NERVOUS SYSTEM IN ACQUIRED IMMUNODEFICIENCY SYNDROME

AIDS and the Nervous System. Rosenblum ML et al, eds. New York, Raven Press, p. 285-300, 1988.. Unique Identifier : AIDSLINE ICDB/89648472
So YT; Choucair A; Davis RL; Wara WM; Ziegler JL; Sheline GE; Beckstead JH; Dept. of Neurology, Box 0114, Room M-794, Univ. of California; Sch. of Medicine, San Francisco, CA 94143

Abstract: The relationship between immune disorders and the development of neoplasms, particularly malignancies involving the hematologic and lymphoreticular systems, has been well established. AIDS-associated neoplasms affect the nervous system in varying degrees. Neurological involvement by these tumors is described, including pathology, neurological presentation, investigations and diagnosis, and treatment. Non-Hodgkin's lymphoma (primary CNS lymphoma and systemic lymphoma) and Kaposi's sarcoma are described. The current theory of oncogenesis in AIDS is speculative. The breakdown of immune regulation in an immunocompromised host may allow lymphoproliferative disorders, such as lymphomas, to evolve from dysregulated immunocytes. Similarly, uncontrolled endothelial proliferation may lead to the formation of Kaposi's sarcoma. With its blood-brain barrier and its lack of lymphatic drainage, the CNS may be relatively protected from normal immune surveillance and regulatory controls. Thus, in a setting of defective immune regulation and antigenic stimulation from infectious agents, the brain may provide a permissive sanctuary for monoclonal or polyclonal lymphocytic proliferation, which could lead to a malignant transformation. (70 Refs)
Keywords: Acquired Immunodeficiency Syndrome/*COMPLICATIONS/PATHOLOGY Brain/PATHOLOGY Brain Neoplasms/*ETIOLOGY/PATHOLOGY/SECONDARY Human Lymphoma, Non-Hodgkin's/ETIOLOGY/PATHOLOGY Sarcoma, Kaposi's/ETIOLOGY/PATHOLOGY MONOGRAPH REVIEW, TUTORIAL REVIEW

KWDacquiredimmunodeficiencysyndrome/KWDcomplications/pathologybrain/pathologybrainneoplasms/KWDetiology/pathology/secondaryhumanlymphoma,non-hodgkin's/etiology/pathologysarcoma,kaposi's/etiology/pathologymonographreview,tutorialreview
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Copyright © 1989 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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