Inhibition of HIV replication by amino-sugar derivatives. NLM AIDSLINE Important note: Information in this article was accurate in 1989. The state of the art may have changed since the publication date.

Click here to return to AIDSLINE main menu
DonateNow
Print this Article


Inhibition of HIV replication by amino-sugar derivatives.

FEBS Lett. 1988 Sep 12;237(1-2):128-32. Unique Identifier : AIDSLINE MED/89005611
Fleet GW; Karpas A; Dwek RA; Fellows LE; Tyms AS; Petursson S; Namgoong SK; Ramsden NG; Smith PW; Son JC; et al; Dyson Perrins Laboratory, Department of Organic Chemistry,; University of Oxford, England.

Abstract: The plant alkaloids castanospermine, dihydroxymethyldihydroxypyrrolidine and deoxynojirimycin have recently been shown to have potential anti-HIV activity [(1987) Proc. Natl. Acad. Sci. USA 84, 8120-8124; (1987) Nature 330, 74-77; (1987) Lancet i, 1025-1026]. They are thought to act by inhibiting alpha-glucosidase I, an enzyme involved in the processing of N-linked oligosaccharides on glycoproteins. We report here the relative efficacy of a spectrum of amino-sugar derivatives as inhibition of HIV cytopathicity. Several alpha-glucosidase inhibitors and alpha-fucosidase inhibitors were found to be active at concentrations which were non-cytotoxic.
Keywords: Amino Sugars/*PHARMACOLOGY Cell Line Comparative Study DNA Replication/DRUG EFFECTS Human HIV/*DRUG EFFECTS HIV-1/DRUG EFFECTS/GENETICS HIV-2/DRUG EFFECTS/GENETICS Molecular Structure Structure-Activity Relationship Support, Non-U.S. Gov't Virus Replication/DRUG EFFECTS JOURNAL ARTICLE

KWDaminosugars/KWDpharmacologycelllinecomparativestudydnareplication/drugeffectshumanhiv/KWDdrugeffectshiv-1/drugeffects/geneticshiv-2/drugeffects/geneticsmolecularstructurestructure-activityrelationshipsupport,non-uKWDsKWDgov'tvirusreplication/drugeffectsjournalarticle
890130
M8910487

Copyright © 1989 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Boehringer Ingelheim, Bridgestone/Firestone Charitable Trust, Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1989. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1989. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .