No predictive value of GC phenotypes for HIV infection and progression to AIDS. NLM AIDSLINE Important note: Information in this article was accurate in 1989. The state of the art may have changed since the publication date.

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No predictive value of GC phenotypes for HIV infection and progression to AIDS.

Hum Genet. 1988 Oct;80(2):181-2. Unique Identifier : AIDSLINE MED/89006652
Pronk JC; Frants RR; Crusius B; Eriksson AW; de Wolf F; Boucher CA; Bakker M; Goudsmit J; Institute of Human Genetics, Free University Amsterdam, The; Netherlands.

Abstract: The genetic polymorphism of group-specific component (GC) was investigated with isoelectric focusing in 351 homosexual men at risk for HIV infection, 96 male patients with AIDS, and 86 heterosexual controls. No significant differences in GC phenotype distribution were seen between controls and any of the at risk groups or patients, neither between HIV-Ab-positive/Ag-negative and HIV-Ab-positive/Ag-positive homosexual men nor between HIV-Ab-positive/Ag-positive homosexual men and AIDS patients, suggesting that the GC system is not involved in the infective susceptibility or progression of HIV infection to AIDS-related complex and AIDS.
Keywords: Acquired Immunodeficiency Syndrome/*GENETICS Human HIV Seropositivity/*GENETICS Isoelectric Focusing Male Phenotype *Polymorphism (Genetics) Predictive Value of Tests Prognosis Vitamin D-Binding Protein/*GENETICS JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/KWDgeneticshumanhivseropositivity/KWDgeneticsisoelectricfocusingmalephenotypeKWDpolymorphism(genetics)predictivevalueoftestsprognosisvitamind-bindingprotein/KWDgeneticsjournalarticle
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M8910479

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