San Francisco, Calif. : The Foundation, c1987 1 videocassette (15 min., 30 sec.) : sd., col. ; 1/2 in Unique Identifier : AIDSLINE AV/8801252A
Campbell J
(Producer) Provides the viewer with graphic and verbal descriptions of the common routes of AIDS transmission, and ways to prevent exposure to the virus. The video also illustrates the virus effect the immune system. People who have tested positive discuss their reactions.
San Francisco, Calif. : J. Wagner, c1987 1 videocassette (28 min.) : sd., col. ; 1/2 in Unique Identifier : AIDSLINE AV/8801278A
Maier C
(Producer) This video documents the goals and findings of California-based research projects studing women and children with AIDS, ARC, or at high risk. A short presentation by US Surgeon General Koop is included. Topics covered include antibody testing, drug use, donor insemination, heterosexual and mother-child t
Atlanta, Ga. : Dept. of Health and Human Services, Public Health Service, Centers for Disease Control, [1986] 50 p. : ill Unique Identifier : AIDSLINE CAT/8812749
Classification of Diseases for North America Hyattsville, Md. : Dept. of Health and Human Services, Public Health Service, National Center for Health Statistics ; Washington, D.C. : For sale by the Supt. of Docs., U.S. G.P.O., [1986] 19 p. : chiefly tables Unique Identifier : AIDSLINE CAT/8813526
within Hospitals within Hospitals Infection Policy Chicago, Ill. : American Hospital Association, c1988 vi, 50 p Unique Identifier : AIDSLINE CAT/8812613
AIDS. The Acquired Immune Deficiency Syndrome. Second Edition. Boston, MTP Press Limited, 188 p., 1987.. Unique Identifier : AIDSLINE ICDB/89648584
Daniels VG; No affiliation given
With the number of people affected with AIDS increasing at an alarming rate--by December 1986 there were almost 30,000 cases in the United States and over 600 cases in the United Kingdom--the epidemic remains a phenomenon of unusual importance and an intense research effort is in progr
This study investigated the frequency of heterosexual transmission of HIV, and the factors that influence this transmission. First, related data were examined in a critical review of the literature and scientific evidence that bears upon these issues. The conclusion of this review was that a widespread heterosexual ep
Natural cell-mediated cytotoxicity (CYT) was determined using whole blood samples from patients (pts) with the acquired immunodeficiency syndrome (AIDS) and AIDS-related complexes (ARC) and correlated to the proportion and absolute number of natural killer (NK) cells as determined by monoclonal antibodies Leu 11 or NK
This study examines psychosocial variables in the process of AIDS in order to describe the experience of AIDS patients (pts) and analyze differences in state anxiety, trait anxiety, and life events 2 yr before diagnosis in cancer pts and AIDS pts. The sample was composed of 30 AIDS pts and 21 cancer pts. AIDS pts were
AIDS and the Nervous System. Rosenblum ML et al, eds. New York, Raven Press, 410 p., 1988.. Unique Identifier : AIDSLINE ICDB/89648459
Anonymous; No affiliation given
This volume describes the effects of HIV on the nervous system with the primary goal of providing rational approaches to the evaluation, diagnosis, treatment, and counseling of patients (pts) with neurological manifestations of AIDS. In addition, the findings and direction of research relevant to AIDS and the nervous
AIDS and the Nervous System. Rosenblum ML et al, eds. New York, Raven Press, p. 1-12, 1988.. Unique Identifier : AIDSLINE ICDB/89648460
Rosenblum ML; Levy RM; Bredesen DE; Dept. of Neurosurgery, Box 0112, Room M-786, Univ. of California; Sch. of Medicine, San Francisco, CA 94143
The neurological manifestations of AIDS are being observed with an increasing frequency that parallels the increasing number of AIDS cases. Neurological syndromes occur in patients (pts) with AIDS, pts with AIDS-related complex (ARC), and in HIV-seropositive pts without other symptoms. Certain diseases associated with
AIDS and the Nervous System. Rosenblum ML et al, eds. New York, Raven Press, p. 65-78, 1988.. Unique Identifier : AIDSLINE ICDB/89648463
Miller RG; Kiprov DD; Parry G; Bredesen DE; Dept. of Clinical Neurology and Neuromuscular Res., Children's; Hosp., 3700 California Street, Room OP613, San Francisco, CA; 94118
Patients (pts) with AIDS or AIDS-related complex (ARC) are susceptible to a wide variety of peripheral nervous system (PNS) complications, including cranial neuropathies. In about one-third of the pts, these complications are caused by secondary pathogens, such as varicella zoster virus or other herpes viruses. Nearly
AIDS and the Nervous System. Rosenblum ML et al, eds. New York, Raven Press, p. 79-101, 1988.. Unique Identifier : AIDSLINE ICDB/89648464
Epstein LG; Sharer LR; Dept. of Neurosciences, Univ. of Medicine and Dentistry of New; Jersey, Medical Sciences Building, Room H506, 100 Bergen St.,; Newark, NJ 07103
Progressive encephalopathy is a common and devastating complication of HIV infection in children. Although it occurs most often in children who have already been diagnosed as having AIDS, progressive encephalopathy may be the first manifestation of HIV infection. The incubation period between exposure to the virus and
AIDS and the Nervous System. Rosenblum ML et al, eds. New York, Raven Press, p. 103-20, 1988.. Unique Identifier : AIDSLINE ICDB/89648465
Holland GN; Kreiger AE; Dept. of Ophthalmology, Jules Stein Eye Inst., Univ. of; California, Los Angeles Sch. of Medicine, 800 Westwood Plaza,; Suite 3-229, Los Angeles, CA 90024
Ophthalmic diseases, including opportunistic infections, vascular disease and neoplasms, are common in patients (pts) with AIDS. Several clinical and autopsy series have shown that 40% to 94% of these pts have clinically apparent ocular or neuroophthalmic disorders. The ocular disorders associated with AIDS fall into
AIDS and the Nervous System. Rosenblum ML et al, eds. New York, Raven Press, p. 121-53, 1988.. Unique Identifier : AIDSLINE ICDB/89648466
De La Paz R; Enzmann D; Dept. of Neuroradiology, Room S070, Stanford Univ. Medical Sch.,; Stanford, CA 94305
Magnetic resonance imaging (MRI) and computerized tomography (CT) scanning are essential in the evaluation of AIDS patients (pts) with neurological symptoms. MRI is the more sensitive of the two techniques, but has poor tissue specificity. A specific etiological diagnosis may not be possible with either technique. Con
AIDS and the Nervous System. Rosenblum ML et al, eds. New York, Raven Press, p. 155-81, 1988.. Unique Identifier : AIDSLINE ICDB/89648467
Nielsen SL; Davis RL; Diagnostic Pathology Medical Group, Dept. of Pathology, Sch. of; Medicine, Univ. of California at Davis, Sacramento, CA
Pathologic changes in the CNS are found in 70-80% of patients (pts) with AIDS who are examined at autopsy. These changes are primarily associated with opportunistic infections and neoplasms. Frequently, multiple, coexisting processes are found in the same pt. The gross and microscopic neuropathology of AIDS is describ
AIDS and the Nervous System. Rosenblum ML et al, eds. New York, Raven Press, p. 183-201, 1988.. Unique Identifier : AIDSLINE ICDB/89648468
McArthur JC; Johnson RT; Dept. of Neurology, The Johns Hopkins Sch. of Medicine, 600 North; Wolfe St., Meyer 6-109, Baltimore, MD 21205
It is clear that HIV has neurotropic properties. Invasion of the nervous system may occur at an early stage of infection with the virus. HIV and the lentivirus family are described and the possible pathogenetic mechanisms of the neurological diseases that may involve direct infection of neural tissues by HIV in patien
AIDS and the Nervous System. Rosenblum ML et al, eds. New York, Raven Press, p. 203-19, 1988.. Unique Identifier : AIDSLINE ICDB/89648469
Price RW; Sidtis JJ; Navia BA; Pumarola-Sune T; Ornitz DB; Dept. of Neurology, Memorial Sloan-Kettering Cancer Inst., New; York, NY 10021
Patients with AIDS are susceptible to a variety of opportunistic infections and neoplasms of the CNS. These patients may also develop a subacute or, more commonly, a chronic progressive CNS disorder characterized by cognitive, motor, and behavioral dysfunction. This disorder, AIDS deme
AIDS and the Nervous System. Rosenblum ML et al, eds. New York, Raven Press, p. 221-61, 1988.. Unique Identifier : AIDSLINE ICDB/89648470
Dix RD; Bredesen DE; Dept. of Ophthalmology, Univ. of Miami Sch. of Medicine, P.O. Box; 016880, Miami, FL 33101
Clinicians now face a growing population of immunodeficient adults who frequently suffer from neurological disorders of viral origin. New patterns of disease have emerged. The clinical course of many viral infections has been profoundly altered, and viruses not commonly associated with neurological disease in the past
AIDS and the Nervous System. Rosenblum ML et al, eds. New York, Raven Press, p. 263-83, 1988.. Unique Identifier : AIDSLINE ICDB/89648471
Pons VG; Jacobs RA; Hollander H; Dept. of Medicine, Div. of Infectious Diseases, Univ. of; California Sch. of Medicine, San Francisco, CA 94143
Infections of the CNS in patients (pts) with AIDS has emerged as one of the most profound problems ever to challenge the medical professions. It is estimated that 15-30% of AIDS pts with abnormal neurological signs or symptoms will have CNS toxoplasmosis, up to 12% will have cryptococcal meningitis, and another 5-10%
AIDS and the Nervous System. Rosenblum ML et al, eds. New York, Raven Press, p. 285-300, 1988.. Unique Identifier : AIDSLINE ICDB/89648472
So YT; Choucair A; Davis RL; Wara WM; Ziegler JL; Sheline GE; Beckstead JH; Dept. of Neurology, Box 0114, Room M-794, Univ. of California; Sch. of Medicine, San Francisco, CA 94143
The relationship between immune disorders and the development of neoplasms, particularly malignancies involving the hematologic and lymphoreticular systems, has been well established. AIDS-associated neoplasms affect the nervous system in varying degrees. Neurological involvement by these tumors is described, includin
AIDS and the Nervous System. Rosenblum ML et al, eds. New York, Raven Press, p. 315-25, 1988.. Unique Identifier : AIDSLINE ICDB/89648473
Ochitill HN; Dilley JW; Dept. of Psychiatry, San Francisco General Hosp., 1001 Potrero; Avenue, San Francisco, CA 94110
Neuropsychiatric dysfunction may precede, accompany, or follow the diagnosis of AIDS. Therefore, it is critical to understand the extent of neuropsychiatric disorder not only among AIDS patients (pts), but also among other groups that lie along the spectrum of AIDS illness. Neuropsychiatric aspects of AIDS are discuss
AIDS and the Nervous System. Rosenblum ML et al, eds. New York, Raven Press, p. 327-45, 1988.. Unique Identifier : AIDSLINE ICDB/89648474
Levy JA; Dept. of Medicine, Cancer Res. Inst., Box 0128, Room M-1282,; Univ. of California Sch. of Medicine, San Francisco, CA 94143
HIV, by its cytopathic effect, morphology, and replication to high titers in T-helper cells, is part of a subfamily of retroviruses known as lentiviruses. The biology of HIV is discussed with emphasis on its role in neurological disease. Topics include the discovery of HIV, evidence for the association of HIV with AID
The neurological syndromes in patients (pts) with AIDS and AIDS-related complex and those with antibodies to HIV are determined at least in part by the degree of immune impairment resulting from HIV infection. Neuroimmunology of HIV infection is discussed, including general immunology, immunology of the CNS, immunolog
AIDS and the Nervous System. Rosenblum ML et al, eds. New York, Raven Press, p. 377-87, 1988.. Unique Identifier : AIDSLINE ICDB/89648476
Bredesen DE; Dept. of Neurology, Box 0114, Room M-794, Univ. of California; Sch. of Medicine, San Francisco, CA 94143
Patients (pts) infected with HIV have a wide spectrum of immunologic background in which neurologic disease often occurs. Therefore, the evaluation of neurologic dysfunction in this group of pts has offered a new angle from which to view neurologic disease in pts without HIV infection. This chapter considers the impli
AIDS and the Nervous System. Rosenblum ML et al, eds. New York, Raven Press, p. 389-95, 1988.. Unique Identifier : AIDSLINE ICDB/89648477
Rosenblum ML; Bredesen DE; Levy RM; Dept. of Neurosurgery, Box 0112, Room M-786, Univ. of California; Sch. of Medicine, San Francisco, CA 94143
Methods of evaluating and treating patients (pts) with AIDS who develop neurologic problems have been in a continuous state of evolution. As new diseases are diagnosed and new treatments are made available, algorithms for clinical decision making are bound to change. Management of pts with neurological complications r
Karpatkin S; New York University School of Medicine, NY 10016.
HIV-seropositive homosexuals, narcotic addicts and hemophiliacs develop a new syndrome of immunologic thrombocytopenic purpura (ITP) which is clinically indistinguishable from classic autoimmune thrombocytopenic purpura (ATP) with respect to increased megakaryocytes in the bone marrow, peripheral destruction of antibo
Bone Marrow Transplant. 1987 Jun;2(1):27-32. Unique Identifier : AIDSLINE MED/89001392
Chan KW; Fryer CJ; Denegri JF; Buskard NA; Phillips GL; Leukemia and Bone Marrow Transplantation Program of British; Columbia, Vancouver General Hospital, Vancouver, Canada.
Six patients with advanced leukemia and one with severe combined immunodeficiency syndrome received allogeneic bone marrow transplantation (BMT) from HLA haploidentical donors who were compatible for one or two loci on the non-shared chromosome. Methotrexate was used for prophylaxis against acute graft-versus-host dis
Visceral leishmaniasis is infrequently reported in immunocompromised hosts; hence, the clinical manifestations and outcome of the disease in these patients are unknown. In a series of 10 patients with visceral leishmaniasis complicating renal transplantation (three), hematologic neoplasms (two), systemic lupus erythem
Tryptophan and kynurenine were measured retrospectively in sera of 11 male patients with advanced human immunodeficiency virus (HIV) infection (Walter Reed stages 4 and 6). Tryptophan levels are significantly reduced to less than 50% in patients with HIV infection and kynurenine levels significantly elevated when comp
Finfer MD; Schinella RA; Rothstein SG; Persky MS; Department of Pathology, New York University Medical Center, NY; 10016.
Twenty-three patients at risk for the acquired immunodeficiency syndrome presented with cystic lesions of the parotid gland. Fourteen patients had unilateral parotid cysts and nine had bilateral enlargement. Ten patients were positive for antibodies to the human immunodeficiency virus (HIV), three were negative for an
Kwok S; Ehrlich G; Poiesz B; Kalish R; Sninsky JJ; Cetus Corporation, Department of Diagnostic Research, Emeryville,; CA 94608.
Human T-cell lymphotropic virus type I (HTLV-I) and human T-cell lymphotropic virus type II (HTLV-II) have been associated with adult T-cell leukemia/lymphoma (ATL) and a rare T-cell variant of hairy cell leukemia, respectively. Direct detection of viral nucleic acid in peripheral blood lymphocytes (PBLs) and infected
Buhrich N; Cooper DA; Freed E; Department of Psychiatry, St Vincent's Hospital, Sydney, New; South Wales, Australia.
Patients with acquired immunodeficiency syndrome (AIDS), who present with or develop psychotic symptoms, almost invariably have evidence of cognitive impairment. Three psychotic patients, one with AIDS, and two with AIDS-related complex (ARC), who showed no evidence of cognitive impairment, are reported. It is suggest
Schmidt U; Miller D; Department of Psychiatry, Middlesex Hospital, London.
HIV disease often leads to neuropsychiatric disturbance, either through direct infection of the brain by the virus or through CNS disease secondary to immunodeficiency. Neuropsychiatric complications of AIDS and AIDS-related disorders may present clinically as acute or chronic organic mental syndromes, or may mimic fu
Huang CM; Ruddel M; Elin RJ; Clinical Pathology Department, Warren Grant Magnuson Clinical; Center, National Institutes of Health, Bethesda, MD 20892.
Nutritional status may be an important factor in the prognosis of morbidity and mortality. We assessed the nutritional status of individuals seropositive for human immunodeficiency virus (HIV) (as confirmed by Western blot) and of patients with AIDS, by determining the concentration in serum of total protein, albumin,
Allwright SJ; Chapman PR; Antico VF; Gruenewald SM; Department of Nuclear Medicine and Ultrasound, Westmead Hospital,; Australia.
Gallium imaging is increasingly being used for the early detection of complications in patients with AIDS. A 26-year-old homosexual man who was HIV antibody positive underwent gallium imaging for investigation of possible Pneumocystis carinii pneumonia. Widespread cutaneous focal uptake was seen, which was subsequentl
Environ Res. 1988 Oct;47(1):1-33. Unique Identifier : AIDSLINE MED/89004990
Wallace R; Department of Epidemiology and Social Medicine, Albert Einstein; College of Medicine, New York, NY.
Techniques adapted from population and community ecology, quantitative geography, and epidemiology are applied to ecosystem and environmental index data on the Bronx in an attempt to understand the origins and potential impacts of rampant spread of human immunodeficiency virus (HIV) and its sequelae of acquired immuno
Hoshi H; Jinnouchi S; Harada K; Watanabe K; Department of Radiology, Miyazaki Medical College, Japan.
Gallium scintigraphy was evaluated in 25 patients with adult T-cell leukemia lymphoma (ATLL). Anterior and posterior images were obtained at 72 h after administration of 3 mCi 67Ga-citrate using a gamma camera (Maxi-Camera 400 T, General Electric Co.) with a medium energy standard parallel hole collimator. Abnormally
FEBS Lett. 1988 Sep 12;237(1-2):128-32. Unique Identifier : AIDSLINE MED/89005611
Fleet GW; Karpas A; Dwek RA; Fellows LE; Tyms AS; Petursson S; Namgoong SK; Ramsden NG; Smith PW; Son JC; et al; Dyson Perrins Laboratory, Department of Organic Chemistry,; University of Oxford, England.
The plant alkaloids castanospermine, dihydroxymethyldihydroxypyrrolidine and deoxynojirimycin have recently been shown to have potential anti-HIV activity [(1987) Proc. Natl. Acad. Sci. USA 84, 8120-8124; (1987) Nature 330, 74-77; (1987) Lancet i, 1025-1026]. They are thought to act by inhibiting alpha-glucosidase I,
Right-sided staphylococcal endocarditis has been described in drug-addict, but not in association with an Acquired Immunodeficiency Syndrome. A case of a 26 years old drug-addict woman with AIDS related complex is reported. Antibiotic therapy, produced a favourable evolution on the illness. This case support the usefu
Frager DH; Wolf EL; Competiello LS; Frager JD; Klein RS; Beneventano TC; Department of Radiology, Montefiore Medical Center--Albert; Einstein College of Medicine, Bronx, New York 10467.
Two patients with Acquired Immunodeficiency Syndrome (AIDS) and infectious esophagitis developed squamous cell carcinoma of the esophagus. The clinical, radiographic, and endoscopic presentations in both cases were atypical. One patient developed a focal flat lesion that imitated segmental esophagitis, and the other p
Gen Hosp Psychiatry. 1988 Sep;10(5):309-16. Unique Identifier : AIDSLINE MED/89006184
James ME; Department of Psychiatry, Emory University School of Medicine,; Grady Memorial Hospital, Atlanta, GA 30335.
The diagnosis of HIV infection is uniquely traumatic to the pregnant patient. Her adjustment is complicated by concerns for her fetus and by coexisting psychiatric disorders. The 15 obstetric patients described demonstrated significant comorbidity, including psychoactive substance abuse or dependence, adjustment and m
Huang TE; Chou SM; Department of Pathology (Neuropathology), Cleveland Clinic; Foundation, OH 44106.
Brain specimens from five immunocompromised patients with CNS toxoplasmosis were studied with immunostaining for toxoplasma antigens and electron microscopy. The tachyzoites or toxoplasma antigens were predominantly localized in walls of hypertrophic, often thrombosed, arteries and adjacent brain tissue at the hyperem
Pronk JC; Frants RR; Crusius B; Eriksson AW; de Wolf F; Boucher CA; Bakker M; Goudsmit J; Institute of Human Genetics, Free University Amsterdam, The; Netherlands.
The genetic polymorphism of group-specific component (GC) was investigated with isoelectric focusing in 351 homosexual men at risk for HIV infection, 96 male patients with AIDS, and 86 heterosexual controls. No significant differences in GC phenotype distribution were seen between controls and any of the at risk group
Terry PM; Page ML; Goldmeier D; Praed Street Clinic, St Mary's Hospital, London.
To assess the value of serological tests in diagnosing and monitoring the response to treatment of syphilis in patients infected with the human immunodeficiency virus (HIV), case notes of eight homosexual men with a history of treated syphilis, positive reactions to serological tests for syphilis, and documented subse
Petersen CS; Sondergaard J; Wantzin GL; Department of Dermatovenereology, Bispebjerg Hospital,; Copenhagen, Denmark.
Testing for antibodies against human immunodeficiency virus (HIV) was introduced in 1984 in this major sexually transmitted disease (STD) clinic in Copenhagen, which is attended by about 10,000 new patients each year. From 1984 to 1987 the proportion of patients examined for antibodies to HIV rose from 6% to 32%. The
Kitchen VS; Cook T; Doble A; Harris JR; Department of Genitourinary Medicine, St Mary's Hospital, London.
A case of granulomatous penile ulceration associated with generalised lymphadenopathy in a homosexual man aged 43 is presented. His serum gave positive results to tests for syphilis, but was negative for antibody to human immunodeficiency virus (HIV). His condition responded briskly to treatment with procaine penicill
Picherack FG; College of Nurses of Ontario, Canada.
The rapidly increasing prevalence of AIDS related mortality and morbidity demands aggressive epidemiologic intervention by the medical and public health systems. Traditional disease prevention strategies alone, will not however, successfully resolve the community health problem of AIDS, particularly in the absence of
Kolbe L; Jones J; Nelson G; Daily L; Duncan C; Kann L; Lawrence A; Broyles B; Poehler D; Division of Health Education, United States Centers for Disease; Control, Atlanta, Georgia.
The ultimate goal of CDC s School Health Education to Prevent the Spread of AIDS programme is to reduce the incidence of HIV infection among school-aged youth. Working objectives that integrate programme research and development activities are listed in the opposite Table. In 1982 it was estimated that of the 4.6 bill
This article is based on information provided by participants at an International Consultation on Public Education and AIDS Prevention, 18-20 October 1987. The meeting was convened by the Federal Centre for Health Education, in collaboration with the World Health Organization , in Colog
Even if we do not have enough distance to comparatively evaluate the preventive actions against AIDS implemented in North America, a few remarks about the respective activities of governments and private sector can be made: Up to 1986, governments have had problems with targeting information campaigns as they were mai
de Neergaard L; National Board of Health, Copenhagen, Denmark.
Educational programmes for adolescents in school cannot be viewed independently, as they will be influenced by other informational activities. It is therefore important to plan the school activities as a part of a much broader community outreach programme. This article however focuses on the programme for adolescent s
Compared with US and European countries, AIDS prevention in Africa has two specificities: there are no peculiar risk groups and the HIV is transmitted mainly through heterosexual relations. In Congo, the prevention strategy aims at the followings: information and in-service training for health workers; medical and psy
Mann J; Global Programme on AIDS, World Health Organization, Geneva,; Switzerland.
A global problem--a global response. AIDS has become a great and powerful symbol for a world threatened by its divisions, East and West, North and South. In a deep and remarkable way, the child with AIDS is the world s child; the man or the woman dying of AIDS has become the world s image of our own mortality; AIDS is
Lin RY; Wildfeuer O; Franklin MM; Candido K; Department of Medicine, Metropolitan Hospital, NYMC, New York.
The levels of C4 and C3 were measured and related to other immunological and clinical parameters in 44 patients with the human immunodeficiency virus (HIV) infection. Circulating immune complexes (C1q-CIC) as measured by an enzyme-linked immunosorbent assay employing monoclonal antibody with specificity for bound Clq,
Ozanne G; Fauvel M; Laboratoire de sante publique du Quebec, Canada.
Anti-human immunodeficiency virus enzyme-linked immunosorbent assay kits marketed by Electro-Nucleonics Inc. (ENI), Genetic Systems Corp. (GSC), Organon Teknika Inc. (OTI), Ortho Diagnostic Systems Inc. (ODSI), and Wellcome Diagnostics (WD) were evaluated by using 289 randomly selected serum samples from a high-risk p
Andersson MA; Bergstrom TB; Blomstrand C; Hermodsson SH; Hakansson C; Lowhagen GB; Department of Neurology, University of Gothenburg, Sahlgren's; Hospital, Sweden.
Cerebrospinal fluid from 34 human immunodeficiency virus (HIV-1) seropositive patients, only four of whom had HIV-related neurological symptoms, was examined by cytology, protein quantification, isoelectric focusing and specific serological tests. CSF lymphocytosis and evidence of intrathecal IgG production, found in
Hara Y; Takahashi M; Ueno S; Yoshikawa H; Yorifuji S; Tarui S; Second Department of Internal Medicine, Osaka University Medical; School, Japan.
We report the demonstration by magnetic resonance (MR) imaging of brain involvement in two of four subjects with human T-cell lymphotropic virus type I (HTLV-I) associated myelopathy. The four cases had slowly progressive spastic paraparesis, urinary incontinence, and positive HTLV-I antibodies in serum or CSF or both
These recommendations update information on the vaccine and antiviral agent available for controlling influenza during the 1988-89 influenza season (superseding MMWR 1987;36:373-380,385-387). Changes include statements about 1) updating of the influenza strains in the trivalent vaccine for 1988-89, 2) increased emphas
Hoff R; Weiblin B; Schwerzler M; Deutch G; Shea B; State Laboratory Institute, Center for Disease Control,; Massachusetts Department of Public Health, Boston.
Hannon WH; Lewis DS; Powell MK; Division of Environmental Health Laboratory Sciences, Centers for; Disease Control, US Department of Health and Human Services,; Atlanta, Georgia.
Lucas C; Nelson C; Peterson ML; Frie S; Vetterlein D; Gregory T; Chen AB; Department of Medicinal and Analytical Chemistry, Genentech,; Inc., South San Francisco, CA 94080.
Two immunoassays have been developed for the quantitation of part-per-million levels of contaminants likely to co-purify with monoclonal antibodies produced in tissue culture and purified by protein A affinity chromatography. These contaminants are bovine IgG originating from the fetal bovine serum used in cell cultur
Novick DM; Farci P; Croxson TS; Taylor MB; Schneebaum CW; Lai ME; Bach N; Senie RT; Gelb AM; Kreek MJ; Department of Medicine, Beth Israel Medical Center, New York, New; York 10003.
We studied unselected, hepatitis B surface antigen (HBsAg)-positive parenteral drug abusers for antibody to hepatitis D virus (anti-HD) and antibody to human immunodeficiency virus (HIV). The prevalences of anti-HD and antibody to HIV were 67% and 58%, respectively, and there was no association between positivity for
J Med Virol. 1988 Jul;25(3):281-8. Unique Identifier : AIDSLINE MED/89010711
Chrystie IL; Almeida JD; Department of Virology, United Medical and Dental Schools of; Guy's Hospital, London, England.
We have examined preparations of human immunodeficiency virus 1 (HIV-1) and HIV-2 by negative staining electron microscopy. HIV-2 cultures contained large numbers of 130-200 nm particles containing a 130-nm-long by 30-70 nm-wide core. This core is probably of conical or pear-shaped morphology. Some particles exhibited
Przedborski S; Liesnard C; Voordecker P; Gerard JM; Taelman H; Sprecher S; Goldman M; Hildebrand J; Service de Neurologie, Hopital Erasme, Brussels, Belgium.
Five patients infected with immunodeficiency virus who were suffering from chronic polyradiculoneuropathy were investigated during evolution of the disease. Four of them were immunodeficient. The prominent neurological feature was distal and symmetrical weakness of the legs. After 5 months only one patient had improve
J Med Chem. 1988 Oct;31(10):2040-8. Unique Identifier : AIDSLINE MED/89011811
Herdewijn P; Balzarini J; Baba M; Pauwels R; Van Aerschot A; Janssen G; De Clercq E; Rega Institute for Medical Research, Katholieke Universiteit; Leuven, Belgium.
A series of base-modified pyrimidine 3 -azido-2 ,3 -dideoxynucleosides and 3 -substituted purine and pyrimidine 2 ,3 -dideoxynucleosides have been synthesized and evaluated for their inhibitory activity against human immunodeficiency virus (HIV) replication in MT-4 cells. The following pyrimidine derivatives emerged a
Tsujimoto H; Cooper RW; Kodama T; Fukasawa M; Miura T; Ohta Y; Ishikawa K; Nakai M; Frost E; Roelants GE; et al; Department of Animal Pathology, University of Tokyo, Japan.
Two isolates of simian retrovirus related to the human immunodeficiency virus (HIV) were obtained from apparently healthy mandrills, Papio (Mandrillus) sphinx, in western equatorial Africa. This virus, designated SIVMND (simian immunodeficiency virus from mandrills), appeared morphologically similar to HIV by electron
Sakai K; Dewhurst S; Ma XY; Volsky DJ; Molecular Virology Laboratory, St. Luke's/Roosevelt Hospital; Center, Columbia, New York, New York.
A cytopathic human immunodeficiency virus type 1 (HIV-1) isolate containing multiple virus genotypes was molecularly cloned, and the biological activity of six randomly selected clones was assessed by transfection into human lymphoid or glial cell lines. Five infectious clones of HIV-1, termed N1T-A through -E, were i
Daniel MD; Li Y; Naidu YM; Durda PJ; Schmidt DK; Troup CD; Silva DP; MacKey JJ; Kestler HW 3d; Sehgal PK; et al; New England Regional Primate Research Center, Harvard Medical; School, Southborough, Massachusetts 01772.
Simian immunodeficiency virus (SIV) was isolated from the total peripheral blood mononuclear cell population and the monocyte-macrophage adherent cell population of three seropositive green monkeys originating from Kenya . SIV from these African green monkeys (SIVagm) was isolated an
Flomenberg PR; Chen M; Horwitz MS; Department of Cell Biology, Albert Einstein College of Medicine,; Bronx, New York 10461.
The early transcription region 3 (E3) of group B adenovirus type 35 (Ad35), a serotype isolated primarily from patients with acquired immunodeficiency syndrome and other immunodeficiency disorders, has been partially sequenced. We had previously identified an Ad35 29-kilodalton (kDa) early glycoprotein which, analogou
Klin Wochenschr. 1988 Aug 1;66(15):682-5. Unique Identifier : AIDSLINE MED/89012814
Serke M; Huhn D; Dienemann D; Eichenlaub D; Sterke S; Stein H; Klinikum Rudolf Virchow der Freien Universitat Berlin.
The clinical and laboratory records of 13 patients with HIV-related lymphomas diagnosed between 1983 and 1987 are reviewed. 8 cases were classified as high-grade Non-Hodgkin-lymphomas (NHL), 4 as low-grade NHL (including 2 plasmocytomas), and one as Hodgkin s disease (HD). 11 of the 12 NHL were of the B-cell lineage.
Wishnow KI; Johnson DE; Department of Urology, University of Texas M.D. Anderson Hospital; and Tumor Institute, Houston 77030.
An unusual presentation of acquired immunodeficiency syndrome (AIDS)--a case of Kaposi s sarcoma involving the glans penis and fossa navicularis--was treated palliatively with neodymium:YAG (Nd:YAG) laser photoablation. A single outpatient treatment removed the two lesions and restored the patient s ability to void no
Med J Aust. 1988 Oct 3;149(7):362-5. Unique Identifier : AIDSLINE MED/89014091
Ross MW; South Australian Health Commission, Adelaide.
A random, stratified sample of 2601 adult Australians from all states and territories was interviewed about knowledge of the acquired immunodeficiency syndrome (AIDS). After the interview, an anonymous questionnaire on the prevalence of practices that are associated with risk of human immunodeficiency virus (HIV) infe
Med J Aust. 1988 Oct 3;149(7):365-8. Unique Identifier : AIDSLINE MED/89014092
Frazer IH; McCamish M; Hay I; North P; Lions Human Immunology Laboratories, University of Queensland,; Department of Medicine, Princess Alexandra Hospital,; Woolloongabba.
A survey was undertaken of homosexual and bisexual men in Brisbane to establish whether knowledge of their human immunodeficiency virus (HIV)-antibody status had influenced any sexual behaviour that was likely to spread HIV type 1 (HIV-1). Of the 318 respondents, 123 respondents knew their HIV serological status, and
Med Microbiol Immunol (Berl). 1988;177(5):235-44. Unique Identifier : AIDSLINE MED/89014155
Tochikura TS; Nakashima H; Ohashi Y; Yamamoto N; Department of Virology and Parasitology, Yamaguchi University; School of Medicine, Japan.
An extract of culture medium of Lentinus edodes mycelia (LEM) was prepared. This was further fractionated by 50% ethanol precipitation and both the resulting product, E-P-LEM, and LEM were studied to evaluate their effect on the activity of human immunodeficiency virus (HIV) in vitro. The experiments were performed us
Recombinant adenoviruses were constructed that contained either the HBsAg coding sequence or the HIV envelope protein coding sequence. The recombinant adenoviruses can replicate normally in cultured human cells. Cells infected with the adenovirus-HBV recombinant secreted HBsAg into the tissue culture medium. This HBsA
De Mercato R; Siciliano V; Formisano S; Belmonte D; Noce S; Rovito G; Ciampi R; Perna V; Fratellanza G; Universita degli Studi di Napoli, II Facolta di Medicina.
An epidemiological study into the prevalence and incidence of anti-H.I.V. antibody seropositivity in closed communities produced preliminary data on 746 subjects, the majority of whom admitted potentially dangerous behaviour. These results demonstrated that residence in a closed community in which one can limit the us
Cimino T; Neirotti S; U.S.S.L. n. 4 - Presidio Ospedaliero Amedeo di Savoia, Torino.
Having examined the literature on the subject, the risk of medical assistants contracting HIV infection accidentally while working in wards where seropositive patients are systematically or occasionally admitted for this viral infection is discussed.
Denson SE; Hoots WK; Pickering LK; Bracey AW; Reves RR; Gresik MV; Werch JS; Department of Pediatrics, University of Texas Medical School,; Houston 77030.
Van Doorne H; Wieringa NF; Bosch EH; De Meijer R; Department of Pharmacy, State University of Groningen, The; Netherlands.
In Third World countries chloroquine phosphate syrup is frequently prepared with chloroform as a preservative. Because of the toxic side effects of chloroform the suitability of a number of possible alternatives were investigated. If the chloroquine phosphate syrup is prepared as such, the combination of sorbic acid (
Proc Natl Acad Sci U S A. 1988 Oct;85(19):7079-83. Unique Identifier : AIDSLINE MED/89017141
Agrawal S; Goodchild J; Civeira MP; Thornton AH; Sarin PS; Zamecnik PC; Worcester Foundation for Experimental Biology, Shrewsbury, MA; 01545.
Modified oligodeoxynucleotides complementary to RNA of human immunodeficiency virus 1 (HIV-1) were tested for their ability to inhibit virally induced syncytium formation and expression of viral p24 protein. The modifications of oligomers include replacement of backbone phosphodiester groups with phosphorothioates and
Proc Natl Acad Sci U S A. 1988 Oct;85(19):7124-8. Unique Identifier : AIDSLINE MED/89017150
Seiki M; Inoue J; Hidaka M; Yoshida M; Department of Viral Oncology, Cancer Institute, Tokyo, Japan.
The pX sequence of human T-cell leukemia virus type I codes for two nuclear proteins, p40tax and p27rex, and a cytoplasmic protein, p21x-III.p40tax activates transcription from the long terminal repeat (LTR), whereas p27rex modulates posttranscriptional processing to accumulate gag and env mRNAs that retain intron seq
Proc Natl Acad Sci U S A. 1988 Oct;85(20):7448-51. Unique Identifier : AIDSLINE MED/89017214
Sarin PS; Agrawal S; Civeira MP; Goodchild J; Ikeuchi T; Zamecnik PC; Laboratory of Tumor Cell Biology, National Cancer Institute,; Bethesda, MD 20892.
Antisense oligodeoxynucleotides containing internucleoside methylphosphonate linkages were examined for their ability to inhibit human immunodeficiency virus (HIV)-induced syncytium formation and virus expression. HIV inhibitory activity was found to be dependent on both chain length and the number of phosphonate resi
Olsen WL; Longo FM; Mills CM; Norman D; Department of Radiology, University of California, San Francisco.
A review of the magnetic resonance (MR) images of 365 patients with acquired immunodeficiency syndrome (AIDS) revealed that 112 (31%) had signal abnormalities confined to the white matter. Four patterns were observed: (a) diffuse: widespread involvement of a large area; (b) patchy: localized involvement with ill-defin
During a period of 16 months 26 fluid specimens obtained by broncho-alveolar lavage (BAL) in 24 immunocompromised patients were examined. This material included 13 HIV positive patients and 11 patients presenting malignant hemopathies (MH), of whom 7 had had a blood marrow transplantation. The BAL fluid was divided in
Loewy EH; University of Illinois College of Medicine, Peoria 61656.
This paper examines ethical behavior in the face of the threat posed by the AIDS epidemic from the vantage point of: (1) different ways of looking at communal structure; (2) notions of justice and of rights which develop from different ways of looking at community; and (3) views of the natural lottery and of self-
Toxicol Lett. 1988 Oct;43(1-3):67-83. Unique Identifier : AIDSLINE MED/89020157
Menzel DB; Duke University Medical Center, Department of Pharmacology,; Durham, NC 27710.
A general method is presented for the use of mathematical modeling in the design, execution, and interpretation of toxicology experiments. To illustrate the use of mathematical modeling toxicology, a case study is presented of how a dosimetry model for inhaled nickel was developed for use in cancer risk estimation. A
Poutiainen E; Iivanainen M; Elovaara I; Valle SL; Lahdevirta J; Department of Neurology, University Central Hospital, Helsinki,; Finland.
Neuropsychological examination was performed on 13 patients and 10 matched controls to assess the brain involvement of patients with human immunodeficiency virus (HIV) infection. HIV-infected patients showed a significant decline in visuomotor, visuoconstructive and practical abilities as well as in motor-free visuosp
Michaels J; Price RW; Rosenblum MK; Department of Neurology, Memorial Sloan-Kettering Cancer Center,; New York, NY 10021.
The autopsied brains of three homosexual men with acquired immune deficiency syndrome (AIDS), progressive encephalopathy and widespread multinucleated giant cell encephalitis were investigated by lectin and immunohistochemical methods to ascertain the cellular distribution of a human immunodeficiency virus (HIV) core
Am Heart J. 1988 Oct;116(4):1105-7. Unique Identifier : AIDSLINE MED/89022745
Steigman CK; Anderson DW; Macher AM; Sennesh JD; Virmani R; Department of Cardiovascular Pathology, Armed Forces Institute of; Pathology, Washington, DC 20306-6000.
Am J Med. 1988 Oct;85(4):472-6. Unique Identifier : AIDSLINE MED/89023162
Kim HC; Raska K 3d; Clemow L; Eisele J; Matts L; Saidi P; Raska K Jr; Department of Medicine, University of Medicine and Dentistry, New; Jersey-Robert Wood Johnson Medical School, New Brunswick; 08903-0019.
PURPOSE: Because of past multiple exposures to contaminated coagulation factor concentrates, the prevalence of human immunodeficiency virus (HIV) infection among adult hemophilic men in the United States is reported to range from 75 to 90 percent. The risk of HIV transmission through a
Minkoff HL; Landesman SH; Department of Obstetrics and Gynecology, State University of New; York, Brooklyn.
Infections with human immunodeficiency virus are becoming increasingly common among women of reproductive age. The consequences of these infections on maternal and child health are substantial. Evidence has been published that suggests that testing only those women recognized as being at risk through physician-elicite
Am J Ophthalmol. 1988 Oct 15;106(4):437-42. Unique Identifier : AIDSLINE MED/89023407
Hamed LM; Schatz NJ; Galetta SL; Department of Ophthalmology, Bascom Palmer Eye Institute,; University of Miami School of Medicine 33101.
Ocular motility manifestations of focal brainstem dysfunction were the initial clinical features in three patients with human immunodeficiency virus (HIV) infection. These included conjugate gaze palsy with ipsilateral facial paresis, bilateral abducens palsy and a gaze paresis, and homolateral internuclear ophthalmop
Am J Public Health. 1988 Nov;78(11):1468-71. Unique Identifier : AIDSLINE MED/89023689
Gregorio DI; Linden JV; Department of Community Medicine and Health Care, School of; Medicine, University of Connecticut Health Center, Farmington; 06032.
Using data from various sources--we estimate that 14 to 19 per cent of American males 17-75 have personal histories that place them at high risk of transmitting the HIV infection while an additional 2 per cent of adult females may be similarly affected. Because roughly one fourth of either group may already be unsuite
Am J Public Health. 1988 Nov;78(11):1472-4. Unique Identifier : AIDSLINE MED/89023690
Winkelstein W Jr; Wiley JA; Padian NS; Samuel M; Shiboski S; Ascher MS; Levy JA; School of Public Health, University of California, Berkeley; 94720.
The incidence of infection by the human immunodeficiency virus (HIV) has been monitored since 1984 in an area probability sample of homosexual/bisexual men drawn from a six-kilometer square area of San Francisco where the epidemic of acquired immunodeficiency syndrome (AIDS) has been most severe. Annualized HIV seroco
Am J Surg. 1988 Oct;156(4):297-300. Unique Identifier : AIDSLINE MED/89023737
Shaha A; Thelmo W; Jaffe BM; Department of Surgery, State University of New York Health; Science Center, Brooklyn.
This report describes a series of 15 patients who presented with masses in the tail of the parotid gland which proved at biopsy to be benign hyperplastic lymphadenopathy similar to lymphoepithelial hyperplasia. There were 11 male and 4 female patients. All had a history of intravenous drug use. Ten patients complained
Ann Allergy. 1988 Oct;61(4):269-72. Unique Identifier : AIDSLINE MED/89024090
Lin RY; Smith JK Jr; Department of Medicine, Metropolitan Hospital, NYMC, NY.
A 39-year-old black male who is an intravenous drug abuser developed certain clinical manifestations that were consistent with the hyper-IgE syndrome. These included an extremely elevated IgE (greater than 2000 IU/mL), extensive eczematoid dermatitis, and recurrent soft tissue infections. He had no history of atopic d
Gan To Kagaku Ryoho. 1988 Oct;15(10):3007-11. Unique Identifier : AIDSLINE MED/89024714
Kohda K; Nakazawa O; Arai R; Takahashi H; Kure T; Terada S; Muramatsu H; Watanabe N; Niitsu Y; Department of Internal Medicine, Asahikawa Red Cross Hospital.
A 37-year-old man was admitted because of general malaise, slight fever, pain in the knee joint and lower extremities, polydypsia, polyuria and skin lesion in September, 1985. The white blood cell count was 16,920/cmm with 41% of abnormal lymphoid cells with convoluted nuclei, which were compatible with adult T-cell l
Gould E; Porto R; Albores-Saavedra J; Ibe MJ; Department of Pathology, University of Miami/Jackson Memorial; Hospital, FL.
The lymph nodes from 50 axillary node dissections were evaluated by light microscopy and immunohistochemistry for the presence of dermatopathic lymphadenitis-like histologic features. On the basis of hematoxylin-eosin-stained sections alone, a histologic continuum was observed ranging from minimal paracortical changes
Davis JM; Chadburn A; Mouradian JA; Department of Surgery, Cornell University Medical College, New; York, NY 10021.
Twenty-one male homosexuals were followed up by repeated lymph node biopsy for a mean (+/- SEM) follow-up of 99 +/- 18 weeks. Four histologic patterns were seen on biopsy: explosive follicular hyperplasia (EFH), follicular involution (FI), a mixed pattern of EFH with FI in the same node, and lymphocyte depletion. Pati
The authors analyse the literature data and propose original assumptions on the role of deranged cellular alterations and persistent carriage of viruses in secondary immunodeficiencies. These are suggested to promote the onset of tumor or tumor-like growth by means of compensatory mechanisms of proliferation enhanced
Baba M; Schols D; Pauwels R; Balzarini J; De Clercq E; Rega Institute for Medical Research, Katholieke Universiteit,; Leuven, Belgium.
Fuchsin acid, an anionic dye, is a selective inhibitor of human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2) in vitro. Its 50% effective dose for inhibition of HIV-1-induced cytopathogenicity in MT-4 cells and HIV-1 antigen expression in HUT-78 cells is 42 and 16 microM, respectively. These values are comp
Dzik JM; Bretner M; Kulikowski T; Ciesla J; Ciesla JM; Rode W; Shugar D; Nencki Institute of Experimental Biology, Academy of Sciences,; Warszawa, Poland.
A study has been made of the interaction of 3 -azido-3 -deoxythymidine 5 -phosphate (AZTMP) and 3 -azido-2 ,3 -dideoxy-uridine 5 -phosphate (AZdUMP) with thymidylate synthase. With the enzyme from L1210 cells and the tapeworm Hymenolepis diminuta, AZTMP was a weak inhibitor competitive with respect to dUMP (Ki = 6.3 m
Biochem Pharmacol. 1988 Oct 1;37(19):3543-8. Unique Identifier : AIDSLINE MED/89025938
Chu CK; Schinazi RF; Arnold BH; Cannon DL; Doboszewski B; Bhadti VB; Gu ZP; Department of Medicinal Chemistry and Pharmacognosy, College of; Pharmacy, University of Georgia, Athens 30602.
Bindokas VP; Gauger JR; Greenberg B; Department of Biological Sciences, University of Illinois at; Chicago.
Mechanisms to explain disturbance of honey bee colonies under a 765-kV, 60-Hz transmission line [electric (E) field = 7 kV/m] fall into two categories: direct bee perception of enhanced in-hive E fields, and perception of shock from induced currents. The same adverse biological effects previously observed in honey bee
Bindokas VP; Gauger JR; Greenberg B; Department of Biological Sciences, University of Illinois,; Chicago.
This work explores mechanisms for disturbance of honey bee colonies under a 765 kV, 60-Hz transmission line [electric (E) field = 7 kV/m] observed in previous studies. Proposed mechanisms fell into two categories: direct bee perception of enhanced in-hive E fields and perception of shock from induced currents. The adv
Uchiyama T; Kamio M; Kodaka T; Tamori S; Fukuhara S; Amakawa R; Uchino H; Araki K; First Department of Internal Medicine, Faculty of Medicine, Kyoto; University, Japan.
The proliferative response of fresh peripheral blood leukemic cells from eight adult T cell leukemia (ATL) patients to interleukin-4 (IL-4) was studied to determine the possibility that the IL-4-mediated T-cell growth pathway is involved in the cell growth of leukemic cells in ATL. Resting lymphocytes from ten normal
Lion T; Razvi N; Golomb HM; Brownstein RH; Joint Section of Hematology/Oncology, University of Chicago; Medical Center.
HTLV-II has been found in some cases of the rare T-cell form of hairy-cell leukemia (HCL) and in a leukopenic chronic T-cell leukemia mimicking HCL. We asked whether the virus is implicated in the more frequent B-cell form of HCL. DNA extracted from the mononuclear cells derived from spleen (eight cases) or peripheral
Cancer. 1988 Oct 15;62(8):1527-30. Unique Identifier : AIDSLINE MED/89002611
Vukelja SJ; Weiss RB; Perry DJ; Longo DL; Section of Medical Oncology, Walter Reed Army Medical Center,; Washington, DC 20307.
Eosinophilia is associated with a number of disorders including malignancies. A patient is described who had eosinophilia associated with adult T-cell leukemia/lymphoma (ATL) induced by human T-lymphotropic virus type I (HTLV-I). Both tissue and peripheral blood eosinophilia and high titers of HTLV-I antibody were pre
Andrieu JM; Eme D; Venet A; Audroin C; Tourani JM; Stern M; Israel-Biet D; Beldjord K; Driss F; Even P; Laennec HIV Study Group, Hopital Laennec, Paris, France.
Serum HIV (P24) antigen (Ag) measured by an antigen capture ELISA (Abbott) and anti-P24-antibodies (Abs) measured by a competitive ELISA (Abbott) and by Western Blot (Dupont de Nemours) analysis were correlated with lymphocyte subsets (CD4 and CD8) in 174 HIV seropositive patients without AIDS (non-AIDS) and 26 with A
Johnson MA; Ahluwalia G; Connelly MC; Cooney DA; Broder S; Johns DG; Fridland A; Division of Biochemical and Clinical Pharmacology, St. Jude; Children's Research Hospital, Memphis, Tennessee 38101.
The pathways of 2 ,3 -dideoxyadenosine (ddAdo) metabolism, a selective inhibitor of the replication of human immunodeficiency virus, were investigated with use of the human T-lymphoid cell line CCRF-CEM which is deficient in either deoxycytidine kinase or adenosine kinase activity, or both. At an extracellular concent
Francis ND; Clark DM; Boylston AW; Pathology Department, St Mary's Hospital Medical School, London.
The use of a new monoclonal antibody, BF1, which reacts in routinely fixed tissues, directed against the beta chain of the T cell antigen receptor was assessed to determine its reactivity in a variety of normal tissues as well as in a number of B and T cell tumours and other lymphoid disorders. It reacted with all fiv
J Immunol. 1988 Oct 1;141(7):2467-73. Unique Identifier : AIDSLINE MED/89009759
Lusso P; Markham PD; Ranki A; Earl P; Moss B; Dorner F; Gallo RC; Krohn KJ; Laboratory of Tumor Cell Biology, National Cancer Institute,; Bethesda, MD 20892.
The specific cellular immune response toward envelope and core proteins of human immunodeficiency virus-1 (HIV-1) was investigated in gibbon apes chronically infected with the HTLV-IIIB isolate. After in vitro stimulation of PBMC from infected and control animals with HIV-1 Ag, DNA synthesis, IL-2R expression and IL-2
J Immunol. 1988 Oct 15;141(8):2607-11. Unique Identifier : AIDSLINE MED/89009784
Tagliabue A; Nencioni L; Mantovani A; Lazzarin A; Villa L; Romano M; Rossini S; Foppa CU; Fanetti G; Masello LC; et al; Sclavo Research Center, Siena, Italy.
Circulating PBMC of healthy subjects possess an in vitro natural antibacterial (NA) against enteropathogenic bacteria, including Salmonella species. The effector cell of NA activity is a CD: 4+, 8-, Leu-8/TQ-1+ T lymphocyte acting against bacteria via cytophylic IgA in a mechanism similar to antibody-dependent cellula
Wenger JD; Whalen CC; Lederman MM; Spech TJ; Carey JT; Tomford JW; Landefeld CS; Department of Medicine, University Hospitals of Cleveland, OH; 44106.
To identify prognostic factors in acquired immunodeficiency syndrome (AIDS), the authors studied an inception cohort of 45 patients in a non-endemic area (Group I). The probability of survival was 67% six months after the diagnosis of AIDS and 32% at 12 months. As shown by multivariate Cox regression analysis, surviva
Mervis RJ; Ahmad N; Lillehoj EP; Raum MG; Salazar FH; Chan HW; Venkatesan S; Laboratory of Molecular Microbiology, National Institute of; Allergy and Infectious Diseases, Bethesda, Maryland 20892.
Seven human immunodeficiency virus gag polypeptides were identified in the purified virus and in infected CD4+ lymphocytes by peptide mapping and limited amino acid sequencing of immune-purified proteins. Two gag polyproteins of 55,000 (p55) and 41,000 (p41) daltons were rapidly labeled and readily processed into the
N Engl J Med. 1988 Oct 27;319(17):1123-7. Unique Identifier : AIDSLINE MED/89014631
N'Galy B; Ryder RW; Bila K; Mwandagalirwa K; Colebunders RL; Francis H; Mann JM; Quinn TC; Project SIDA, Department of Public Health, Kinshasa, Zaire.
To define the prevalence and course of human immunodeficiency virus (HIV) infection, we examined prospectively a cohort of 2002 adult hospital workers in Kinshasa, Zaire . From 1984 to 1986 the prevalence of HIV infection increased from 6.4 percent to 8.7 percent. Over the two year
Nature. 1988 Oct 20;335(6192):738-40. Unique Identifier : AIDSLINE MED/89014746
Rimsky L; Hauber J; Dukovich M; Malim MH; Langlois A; Cullen BR; Greene WC; Howard Hughes Medical Institute, Department of Medicine, Duke; University Medical Center, Durham, North Carolina 27710.
Two evolutionarily distinct families of human retroviruses, the human immunodeficiency viruses (HIV) and the human T-cell leukaemia viruses (HTLV), have been defined (reviewed in ref. 1). Although these virus groups share tropism for human CD4+ T cells, they differ markedly in primary sequence, genetic organization an
Nucl Med Commun. 1988 Jul;9(7):513-6. Unique Identifier : AIDSLINE MED/89015504
Sabbatani S; Monti C; Turba E; Raise G; Division of Infectious Disease, Major Hospital, Bologna, Italy.
Problems in the investigation of pulmonary interstitial pneumocystis carinii in AIDS patients in the early phase with 67Ga, high-resolution CT scan and chest X-ray are discussed, and a clinical study of 12 individuals is presented. The combination of the three examinations is useful in reducing false negative cases. T
Jason JM; Stehr-Green J; Holman RC; Evatt BL; Division of Host Factors, Centers for Disease Control, Atlanta,; GA 30333.
The following groups were compared: (1) children less than 18 years old who have hemophilia-associated acquired immunodeficiency syndrome (AIDS) with other children with AIDS and with adults who have hemophilia-associated AIDS and (2) asymptomatic HIV-infected hemophilic children with asymptomatic HIV-infected hemophi
Science. 1988 Oct 21;242(4877):426-30. Unique Identifier : AIDSLINE MED/89019375
Nakamura S; Salahuddin SZ; Biberfeld P; Ensoli B; Markham PD; Wong-Staal F; Gallo RC; Laboratory of Tumor Cell Biology, National Cancer Institute,; Bethesda, MD 20892.
Studies of the biology and pathogenesis of Kaposi s sarcoma (KS) have been hampered by the inability to maintain long-term cultures of KS cells in vitro. In this study AIDS-KS-derived cells with characteristic spindle-like morphology were cultured with a growth factor (or factors) released by CD4+ T lymphocytes infect
Levine PH; Jaffe ES; Manns A; Murphy EL; Clark J; Blattner WA; Environmental Epidemiology Branch, National Cancer Institute,; Bethesda, Maryland 20892.
Ninety-six patients with the diagnosis of adult T-cell leukemia/lymphoma (ATLL) were identified in countries outside Japan and the Caribbean Basin. Seventy-four of these patients were initially diagnosed in the United States ; 25 of 52 patients whose
Voelkerding KV; Sandhaus LM; Belov L; Frenkel L; Ettinger LJ; Raska K Jr; Department of Pathology, University of Medicine and Dentistry of; New Jersey, Piscataway.
An infant with congenital human immunodeficiency virus (HIV) infection had immune thrombocytopenic purpura (ITP) develop at four months of age. A bone marrow aspirate had normal results in morphologic characteristics and cellularity. Flow cytometry analysis of the marrow cells showed that the predominant cell in the l
Ann N Y Acad Sci. 1988;532:207-13. Unique Identifier : AIDSLINE MED/89024305
Bernstein DC; Shearer GM; Immunology Branch, National Cancer Institute, Bethesda, Maryland; 20892.
Cytotoxic T lymphocyte (CTL) responses to HLA alloantigens are unexpectedly weak compared to the CTL response to influenza virus. Allogeneic CTL activity was increased dramatically by removal of a Leu M3+ cell with adherence properties. The Leu M3+-enriched population was capable of suppressing the allogeneic-CTL resp
Chaisson RE; Leuther MD; Allain JP; Nusinoff-Lehrman S; Boone GS; Feigal D; Volberding P; Medical Service, San Francisco General Hospital.
We assessed the effect of antiviral therapy on serum human immunodeficiency virus core antigen (HIV-Ag) levels in patients enrolled in the phase II trial on zidovudine for acquired immunodeficiency syndrome (AIDS) and AIDS-related complex. Human immunodeficiency virus core antigen was detected in 45% of subjects at en
Hamamoto Y; Hirashima S; Natori S; Yamamoto N; Kobayashi N; Department of Virology and Parasitology, Yamaguchi University; School of Medicine, Japan.
We have examined the expression of a novel transcription factor SII in HIV-infected cells. Concomitant with the increasing expression of HIV-1 mRNA, the viability of HIV infected cells dropped and the expression of beta-actin gene also diminished. Concurrently, the expression of SII mRNA was stabilized or augmented. T
N Engl J Med. 1988 Oct 27;319(17):1118-23. Unique Identifier : AIDSLINE MED/89014630
Marcus R; Hospital Infections Program, Centers for Disease Control,; Atlanta, GA 30333.
Since 1983, we have conducted national surveillance of health care workers exposed to blood or body fluids from persons infected with the human immunodeficiency virus (HIV), to assess the risk of HIV transmission by such exposures. As of July 31, 1988, 1201 health care workers with blood exposures had been examined, i
Sehgal S; Arora SK; Rajwanshi A; Deodhar SD; Department of Immunopathology, Postgraduate Institute of Medical; Education and Research, Chandigarh, India.
Sera from 3500 individuals including patients of non-Hodgkin s lymphoma , patients with sexually transmitted diseases, leprosy, jail inmates, healthy laboratory workers and patients on hemodialysis were screened for antibodies against human immunodeficiency virus (HIV) as a sero sur
Glasscock ME 3d; Jackson CG; Knox GW; Otology Group, Vanderbilt University School of Medicine,; Nashville, TN 37203.
Materials commonly employed in the preparation of otologic homografts such as ethanol and formaldehyde are effective in vitro in inactivating human immunodeficiency virus (HIV). However, to our knowledge, the complete permeation of homograft materials with preservative has not been demonstrated. Ethanol and formaldehy
McAllister RH; Harrison MJ; Johnson M; Middlesex Hospital Medical School, London.
Neurological manifestations are common in HIV-infected individuals. Autopsy data suggest that the brain may be affected in as many as 80 per cent of cases. While opportunistic infections represent a major cause of neurological morbidity and mortality, there is growing evidence that HIV is itself neurotropic and can di
Cancer Res. 1988 Nov 1;48(21):6081-9. Unique Identifier : AIDSLINE MED/89002784
Butler LD; Browne CP; Layman NK; Riedl P; Tang J; Marder P; DeLong D; Manetta J; Bobbitt L; Strnad J; et al; Department of Immunology Research, Lilly Research Laboratories,; Indianapolis, Indiana 46285.
We have examined the ability of in vivo treatment of mice with recombinant interleukin 2 (rIL-2) to affect natural immunity measured against tumor (YAC-1) or virally infected (herpes simplex type 1) target cells. rIL-2 treatment leads to significant increases in natural killer/lymphocyte-activated killer (NK/LAK) func
Cell. 1988 Oct 21;55(2):197-209. Unique Identifier : AIDSLINE MED/89003058
Siomi H; Shida H; Nam SH; Nosaka T; Maki M; Hatanaka M; Institute for Virus Research Kyoto University, Japan.
The posttranscriptional regulator (p27x-III) of human T cell leukemia virus type I (HTLV-I) is located predominantly in the cell nucleolus. A highly basic amino-terminal sequence (NH2-Met-Pro-Lys-Thr-Arg-Arg-Arg-Pro-Arg-Arg-Ser-Gln-Arg-Lys-Arg-- Pro-Pro -Thr- Pro) in this protein, when fused to the amino termini of be
Maggiolo F; Bianchi W; Ohnmeiss H; Bayer Italia S.p.A., Medical Department, Milan, Italy.
Infective complications not only remain the major factor in preventing a large proportion of cancer patients from achieving a complete remission, but also greatly influence the outcome of immunosuppressed transplant recipients and are a prominent problem in subjects affected by AIDS. We report the results of 73 patien
Penneys NS; Department of Dermatology, University of Miami School of; Medicine, Florida.
Dermatologists function as consultants in the management of AIDS. They are consulted for care of cutaneous complications such as superficial infections (viral, dermatophyte, deep fungal, and bacterial). The management of these problems is similar to that in individuals with intact immune systems; however, these proces
Glaser AM; Chen DC; Siegel ME; Department of Radiology, University of Southern California, Los; Angeles County Medical Center 90033.
Although Ga-67 has been used extensively in imaging many different conditions, much is yet unknown about the mechanisms by which gallium concentrates preferentially in tissues such as the liver. This paper reports three patients with markedly diminished hepatic uptake of gallium. The cases are examined in light of pub
Scalfano FP Jr; Prichard JG; Lamki N; Athey PA; Graves RC; Department of Radiology, Baylor College of Medicine, Houston,; Texas 77030.
Cryptococcosis is a recognized opportunistic pathogen in the acquired immune deficiency syndrome. Although central nervous system infection and disseminated cryptococcosis is common in acquired immune deficiency syndrome, localized infection is rare. We present a case of massive retroperitoneal and mesenteric adenopat
Retroviruses code for a specific protease which is essential for polyprotein precursor processing and viral infectivity. The HIV-specific protease has been predicted to be an aspartic protease which is located at the amino terminus of the pol gene. We have prepared several constructs for bacterial expression of the pr
Geogr Med Suppl. 1988;1:11-8. Unique Identifier : AIDSLINE MED/89006226
Arbesser C; Sixl W; Institute of Hygiene, University of Graz, Austria.
In the spring of 1986, 3.473 human blood samples were serologically screened for HIV-antibodies. The methods used were ELISA (enzyme-linked immunosorbent assay), immunoblotting (Western Blot) and the indirect immunofluorescence assay (IFA). The blood samples were collected from males and females of all age groups in:
Sng EH; Tan BB; Chik HL; Department of Pathology, Singapore.
A comparative evaluation of a new serological test for human immunodeficiency virus (HIV) was carried out. The test used the agglutination of gelatin particles coated with HIV antigen. It was found to be more sensitive than current enzyme linked immunosorbent assays (ELISAs) and more specific than the western blot tes
Sievert W; Merrell RC; University of Texas Health Science Center, Department of Surgery,; Houston.
Opportunistic infection and neoplasia involving the gastrointestinal tract are common in AIDS patients. Life-threatening complications of this involvement may occur, requiring urgent diagnosis and therapy. We review the clinical presentation and approaches to management of AIDS-related gastrointestinal emergencies.
Janoff EN; Smith PD; Department of Medicine, Veterans Administration Medical Center,; Minneapolis, Minnesota.
Gastrointestinal illnesses are among the most common and debilitating complication of infections with HIV, affecting 50 per cent to almost 100 per cent of AIDS patients in developed and developing countries, respectively. A number of factors including relevant modes of transmission, the environment, and immunosuppress
Friedman SL; University of California, San Francisco.
There is an increased frequency of Kaposi s sarcoma and non-Hodgkin s lymphomas in patients with AIDS. These opportunistic malignancies establish the diagnosis of AIDS in an HIV-positive patient and are associated with a high likelihood of gastrointestinal and hepatobiliary involvement. Kaposi s sarcoma is a multicent
Rodgers VD; Kagnoff MF; University of California, San Diego.
Significant abnormalities in the distribution of lymphocyte subsets have been noted in the intestinal mucosa of ARC and AIDS patients. Abnormalities are most striking among the CD4 helper-inducer T-cell subset and likely reflects the direct effects of HIV infection of those cells. A deficiency in CD4-positive T cells
Raufmann JP; Straus EW; Department of Medicine, SUNY-Health Science Center, Brooklyn.
Gastroenterologists are frequently asked to perform endoscopy on patients with AIDS. A survey of university-based endoscopy units in the United States indicates that at the majority of these centers, endoscopic personnel are concerned about the risk of contracting AIDS and that these c
Jeffrey RB Jr; Department of Radiology, San Francisco General Hospital,; California.
Radiologic imaging with computed tomography (CT) and ultrasound (US), when combined with guided fine-needle aspiration biopsy (FNAB) can diagnose a broad spectrum of gastrointestinal, visceral, and nodal abnormalities in AIDS.
Wall SD; Department of Radiology, VA Medical Center (Fort Miley), San; Francisco, California.
Barium radiography of the gastrointestinal tract in patients with AIDS can assist in the evaluation of numerous problems including dysphagia, odynophagia, diarrhea, abdominal pain, symptoms of intermittent obstruction, and/or gastrointestinal bleeding. It can localize disease, evaluate complications, guide endoscopic
Greenspan D; Greenspan JS; University of California, San Francisco School of Dentistry.
Patients with HIV infection and AIDS frequently experience one or more oral lesions at some time during the course of their disease. Recognition and management of these oral manifestations is an important component of AIDS care.
Macho JR; University of California, School of Medicine, San Francisco.
The acquired immunodeficiency syndrome is associated with opportunistic infections and unusual malignancies that may affect the gastrointestinal tract. The number of patients affected by this condition is large and will continue to increase. The manifestations of the disease may mimic acute surgical conditions. In add
Greene JB; New York University School of Medicine, New York.
The loss of body weight is a common finding in the setting of AIDS or ARC. Weight loss usually heralds the appearance of an AIDS-associated infectious disease or neoplasm. Multiple mechanisms for catabolism exist, including decreased caloric intake, excessive caloric loss, and increased metabolic caloric consumption.
Smith PD; Janoff EN; Cellular Immunology Section, National Institute of Dental; Research, Bethesda, Maryland.
Gastrointestinal symptoms, particularly diarrhea, are common in patients with AIDS. Recent evidence indicates that enteric pathogens can be identified in most of these cases. Appreciating the clinical features caused by protozoal, fungal, bacterial, and viral pathogens will assist the clinician in effectively evaluati
Raufman JP; Department of Medicine, State University of New York-Health; Science Center, Brooklyn.
Odynophagia and dysphagia are common symptoms of treatable disorders of the esophagus in patients with AIDS. Esophageal candidiasis is the most frequent cause of these symptoms. In patients with AIDS or AIDS-related complex, thrush in combination with odynophagia or dysphagia a
Schneiderman DJ; University of Arizona School of Medicine, Tucson.
Liver disease, although usually asymptomatic, is a frequent accompaniment of AIDS. Hepatomegaly and macrosteatosis are prevalent but non-specific findings. Evidence of remote hepatitis B virus infection is extremely common; however, the HBsAg carrier state, chronic active hepatitis, or cirrhosis occur no more frequent
Barone JE; Wolkomir AF; Muakkassa FF; Fares LG 2d; Robert Wood Johnson Medical School, New Jersey.
The diagnosis and treatment of abdominal pain and anorectal disease in AIDS patients are discussed. Emphasis is placed on the practical aspects of patient care.
Cello JP; Wilcox CM; Department of Medicine, University of California, San Francisco; General Hospital.
Hemodynamically significant gastrointestinal tract hemorrhage is infrequently seen among patients with AIDS. During a 35-month period, we evaluated 37 AIDS patients with substantial gastrointestinal tract bleeding: 13 patients had upper gastrointestinal disease; 24 patients had colorectal disease. AIDS-associated lesi
Gallo D; Hoffman MN; Cossen CK; Diggs JL; Hurst JW; Penning LM; Viral and Rickettsial Disease Laboratory, State of California; Department of Health Services, Berkeley 94704.
A total of 3,349 serum samples were screened by the immunofluorescence (IF) method for antibody to human T-cell leukemia virus type I (HTLV-I). Only 9 of 2,409 specimens from selected individuals, blood bank donors, patients with encephalitis-meningitis, and human immunodeficiency virus antibody-positive homosexual or
Penneys NS; Bernstein H; Leonardi C; Department of Dermatology, University of Miami School of; Medicine, FL.
By the use of polyclonal antibody to type IV collagen that binds to epitope(s) retained in routinely processed tissues, we have confirmed the presence of early Kaposi s sarcoma in skin lesions that were not diagnostic on histologic examination. This reagent is of considerable use, particularly in cases of rapidly deve
Krigel RL; Slywotzky CM; Lonberg M; Green MD; Andes WA; Kempf R; Gupta S; Grace W; Spiegel RJ; Muggia FM; et al; Rita and Stanley H. Kaplan Cancer Center, New York, New York.
A prospective clinical trial of concomitant interferon-alpha 2b and etoposide was conducted in 24 previously untreated patients with epidemic Kaposi s sarcoma. Eight of 21 evaluable patients (38%) achieved either a complete response (1 patient) or a partial response (7 patients). None of the responders had a prior his
Since the inception of sexology as an academic discipline a century ago, the boundary between sexology, the science, and sexosophy, the philosophy of sex, has been poorly demarcated, especially with respect to the principles of sex-reform movements. Several early 20th centruy sexologists overtly espoused the principle
Krausslich HG; Schneider H; Zybarth G; Carter CA; Wimmer E; Department of Microbiology, State University of New York, Stony; Brook 11794-8621.
We expressed the gag and proteinase regions of human immunodeficiency virus (HIV) type 1 by transcription and translation in vitro. A synthetic RNA spanning the gag and pro domains gave primarily the unprocessed capsid precursor pr53. Efficient cleavage of this precursor was observed when the gag and pro domains were
Kawatani T; Hattori N; Kurimura T; Department of Virology, Tottori University School of Medicine.
Two T-cell lines, TALL-1 and CCRF-CEM, were infected with human immunodeficiency virus (HIV), strain LAV, to explore the time course of the appearance of various virus specific antigens, and to establish an antibody assay system by indirect immunofluorescence (IF). These cells were infected with LAV at two different i
Med J Aust. 1988 Aug 15;149(4):198-202. Unique Identifier : AIDSLINE MED/89014070
Waters BG; Ziegler JB; Hampson R; McPherson AH; Prince of Wales Hospital, Randwick, NSW.
This article reviews the available medical literature on the psychosocial and neuropsychiatric implications of childhood infection by the human immunodeficiency virus. This information is supplemented by discussion of cases from our clinical experience. It is clear that different psychosocial issues are confronted by
On the basis of personal experience, the microbiological, epidemiological, clinical and therapeutic features of Pneumocystis carinii pneumonia are analysed.
Ghiringhelli P; Ghiringhelli L; Ospedale Provinciale di Gallarate Divisione di Medicina 1.
The diseases responsible for lymphadenopathies with autoimmune features were examined. Such features play a major role in a vast number of clinical conditions whose aetiology is for the most part unknown but which present several clinical, histological and laboratory aspects in common. The most significant of these co
Postgrad Med J. 1988 Mar;64(749):180-7. Unique Identifier : AIDSLINE MED/89016922
Kennedy PG; Glasgow University Department of Neurology, Southern General; Hospital, UK.
The protean neurological manifestations of human immunodeficiency virus (HIV) infection are reviewed. Both the central nervous system and peripheral nervous system may be affected and many of the complications may occur in individuals with acquired immunodeficiency syndrome (AIDS)-related complex, or who are seroposit
Proc Natl Acad Sci U S A. 1988 Oct;85(19):7129-33. Unique Identifier : AIDSLINE MED/89017151
Nutt RF; Brady SF; Darke PL; Ciccarone TM; Colton CD; Nutt EM; Rodkey JA; Bennett CD; Waxman LH; Sigal IS; et al; Department of Medicinal Chemistry, Merck Sharp & Dohme Research; Laboratories, West Point, PA 19486.
Retroviral proteins, including those from the human immunodeficiency virus (HIV), are synthesized as polyprotein precursors that require proteolytic cleavage to yield the mature viral proteins. A 99-residue polypeptide, encoded by the 5 end of the pol gene, has been proposed as the processing protease of HIV. The che
Groopman JE; Division of Hematology/Oncology, New England Deaconess Hospital,; Boston, MA 02215.
Research in recombinant DNA technology has led to the characterization of colony-stimulating factors (CSFs) as a family of glycoprotein hormones that are thought to regulate blood cell proliferation and differentiation. CSFs also have been studied for their potential use in treating various hematologic, infectious, an
South Med J. 1988 Oct;81(10):1282-5. Unique Identifier : AIDSLINE MED/89019521
Sharp SC; Vanderbilt University School of Medicine, Nashville, Tenn.
Medicine s triumph over contagious disease through improved techniques of prevention and treatment in the decades before the appearance of the acquired immunodeficiency syndrome (AIDS) left physicians with little impetus to explore their feelings regarding the acceptance of personal risk in the course of patient care.
Zhdanov VM; Karamov EV; Arakelov SA; Rudneva IA; Ketiladze ES
An enzyme immune diagnosticum for the detection of the antigen and antibody to human immunodeficiency virus (HIV) has been developed at D. I. Ivanovskii Institute of Virology of the USSR AMS. The method is based on the principle of competitive analysis using an antiviral conjugate which allows the sera to be tested wi
Zaides VM; Berezin VE; Bubnov VV; Kliushnik SIu; Korobov LI
Among 1002 foreign students examined in Odessa 11 subjects with antibody to HIV, i.e. infected with HIV, were detected. A complete agreement of the results of the enzyme immunoassay and immune blotting test was observed. The reasons of this are discussed. A specific regional distribution of seropositive subjects by th
Kuller LH; Department of Epidemiology, Graduate School of Public Health,; University of Pittsburgh, Pennsylvania 15261.
Prevention of transmission of HIV infection is the most important public health concern of the AIDS epidemic. To date, unfortunately, we have failed to contain the epidemic. The increasingly rapid spread of HIV into the IV drug-abusing population and subsequent heterosexual transmission represent a further failure of
The discovery of the Human Immunodeficiency Virus (HIV), the characterization of its molecular biology and the development of serologic methods for detecting antibodies have led to a better understanding of HIV-associated clinical syndromes. Recently, the Centre of Disease Control has proposed a classification of HIV-
Robinson RG; Department of Family Practice, Self Memorial Hospital, Greenwood,; SC.
Infectious mononucleosis, a systemic illness caused by the Epstein-Barr virus, is seen frequently by primary care physicians. Mononucleosis affects several organ systems, and, within the abdomen, there can be splenic involvement, hepatitis, mesenteric lymphadenopathy, hyperplasia of gut-associated lymphoid tissue, pan
Am Fam Physician. 1988 Oct;38(4):205-13. Unique Identifier : AIDSLINE MED/89022717
Hamrick RM 3d; Yeager H Jr; Georgetown University Medical Center, Washington, D.C.
Tuberculosis cases are increasing in the United States , partly because of the emergence of AIDS and the rise in the homeless population. Faster culture methods usually allow identification within two weeks. Research is being done on serologic and recombinant nucleic acid methods of det
Am J Ophthalmol. 1988 Oct 15;106(4):463-6. Unique Identifier : AIDSLINE MED/89023411
Goode SM; Hertzmark E; Steinert RF; Department of Ophthalmology, Harvard Medical School, Boston.
Using a simple mathematical model, we calculated the risk for a patient undergoing penetrating keratoplasty to receive a cornea from a human immunodeficiency virus-infected donor despite negative results on serologic testing of donor serum. This error in serologic testing occurred when false-negative results were obta
AIDS will become a bigger and bigger problem in future, especially for medical staff who will be increasingly in contact with infected patients. The epidemiology of HIV infection (blood, vaginal secretion, sperm) and the threat of this infection require particularly strict observance of hygienic measures. Unqualified
Lucente FE; Meiteles LZ; Pincus RL; Department of Otolaryngology, New York Eye and Ear Infirmary, New; York Medical College, New York.
Among the more common manifestations of acquired immunodeficiency syndrome (AIDS) are tumors and infections that occur in regions treated by the bronchoesophagologist. In reviewing our institutional experience in the diagnosis and treatment of 396 patients with AIDS in 1987, we have noted that 226 (57%) had some form
Gan To Kagaku Ryoho. 1988 Oct;15(10):2975-81. Unique Identifier : AIDSLINE MED/89024708
Ichimaru M; Kamihira S; Moriuchi Y; Kuraishi Y; Usui N; Toki H; Okabe K; Niho Y; Shibuya T; Umei T; et al; Dept. of Hematology, Nagasaki University, School of Medicine.
The phase II trial of natural interferon-alpha (HLBI) in treatment of adult T-cell leukemia was carried out as a cooperative study. Of the 24 cases which could be evaluated, 3 cases in crisis type and 5 cases in chronic type with lymphadenopathy and/or skin infiltration achieved PR, giving a response rate of 33.3%. Th
Biochem Biophys Res Commun. 1988 Oct 14;156(1):297-303. Unique Identifier : AIDSLINE MED/89025858
Darke PL; Nutt RF; Brady SF; Garsky VM; Ciccarone TM; Leu CT; Lumma PK; Freidinger RM; Veber DF; Sigal IS; Department of Molecular Biology, Merck Sharp and Dohme Research; Laboratories, West Point, Pennsylvania 19486.
The mature proteins of retroviruses originate as a result of proteolytic cleavages of polyprotein precursors. Retroviruses encode proteases responsible for several of these processing events, making them potential antiviral drug targets. A 99-amino acid HIV-1 protease, produced by chemical synthesis or by expression i
Bonneux L; Van der Stuyft P; Taelman H; Cornet P; Goilav C; van der Groen G; Piot P; Department of Microbiology, Institute of Tropical Medicine,; Antwerp, Belgium.
The pattern of cases of AIDS in Belgium suggests that Europeans infected with human immunodeficiency virus (HIV) acquired the infection in Africa. The prevalence of infection was assessed in Belgian advisers and European expatriates and risk factors for infection defined in a case
Hoffner SE; Department of Bacteriology, National Bacteriological Laboratory,; Stockholm, Sweden.
A reconsideration of the laboratory methods used for primary isolation of mycobacteria other than Mycobacterium tuberculosis is needed due to the increasingly recognized importance of such mycobacterial infections in immunocompromised patients. One example of this is the severe opportunistic infections caused by Mycob
Hickey MS; Weaver KE; University of California, San Francisco.
Investigators are now predicting that 75 to 80 per cent of the 1.5 to 2.0 million HIV-positive patients in the United States will develop AIDS. The majority of AIDS patients will experience progressive weight loss and malnutrition prior to their death. Because nutritional therapy has c
Takeuchi T; Kubonishi I; Takahashi K; Ohtsuki Y; Taguchi H; Miyoshi I; Department of Medicine, Kochi Medical School, Nankoku.
A novel monoclonal antibody, designated D-213, was generated to human myeloid cell line PL-21. D-213 defined a 47-kD antigen which was specifically expressed in normal and leukemic cells of the myeloid lineage and in T-cell lines carrying human T-cell leukemia virus type I. This antibody was also reactive with adult T
Akagi T; Yoshino T; Motoi M; Takata H; Yano S; Miyoshi I; Oka T; Ohtsuki Y; Department of Pathology, Okayama University Medical School.
A human anaplastic gastric cancer cell line, HGC-27, showed marked degeneration with formation of multinucleated syncytia and cell detachment of nearly all cells which began 24 hr after and reached a maximum 2 to 3 days after co-cultivation with X-irradiated MT-2 cells, HTLV-I producing human cord leukocytes. Less sev
Sano H; Sato S; Shima J; Tada T; Fujiwara H; Hamaoka T; Department of Oncogenesis, Osaka University Medical School.
C3H/He mice hyperimmune against syngeneic MH134 hepatoma were prepared by intradermal (id) inoculation of viable tumor cells followed by surgical resection of the tumor and by repeated id challenges with viable tumor cells. Winn assays performed utilizing spleen cells from these mice have revealed that both Lyt-2+ and
Caruso A; Terlenghi L; Scalzini A; Verardi R; Foresti I; Pollara P; Bonfanti C; Ravizzola G; Manca N; Turano A; Institute of Microbiology, University of Brescia, Italy.
A stable hybridoma cell line secreting specific antibodies against human interferon-gamma (IFN-gamma) and designated IGMB-14 has been established. It belongs to the IgG1, kappa subclass and it reacts in Western blot with the 28 kDa and 56 kDa polypeptides present in two different affinity purified IFN-gamma preparatio
2 cases of disorders of craniofacial nerves resulting from progressive multifocal leucoencephalopathy are described. Clinical symptoms occurred as facial paralysis, hypaesthesia, hemianopsia and deafness. In both patients, the impairment of the central nervous system (CNS) preceded indicative AIDS symptoms. Both patie
J Med Virol. 1988 Jul;25(3):317-27. Unique Identifier : AIDSLINE MED/89010715
Williams MD; Boxall EH; Hill FG; Haematology Department, Birmingham Children's Hospital, England.
Eleven of 27 haemophilic boys who received a common batch of Factor VIII concentrate subsequently developed acute hepatitis B; although 9 were considered not to have been previously exposed to the virus, 2 other boys had been considered immune to hepatitis B. The amount of concentrate received by each child, together
Poletti A; Manconi R; Volpe R; Carbone A; Division of Pathology, Cancer Centre, Aviano, Italy.
Salivary gland lymph node involvement is rare in patients at risk for AIDS. Intraparotid and perisubmaxillary gland lymph node biopsies from 2 intravenous drug abusers serologically positive for human immunodeficiency virus (HIV) affected by persistent generalized lymphadenopathy (PGL) were also analyzed immunohistolo
JAMA. 1988 Oct 21;260(15):2236-9. Unique Identifier : AIDSLINE MED/89012354
Jackson JB; Sannerud KJ; Hopsicker JS; Kwok SY; Edson JR; Balfour HH Jr; Department of Laboratory Medicine and Pathology, University of; Minnesota, Minneapolis 55455.
Cultures of peripheral blood mononuclear cells for human immunodeficiency virus type 1 (HIV-1) and assays for the p24 antigen were performed for a group of 75 unselected hemophiliacs to determine whether patients positive for HIV-1 antibody are actively infected rather than immunized by viral proteins in non-heat-trea
NIDA Res Monogr. 1988;83:1-14. Unique Identifier : AIDSLINE MED/89014681
Newell GR; Spitz MR; Wilson MB; Department of Cancer Prevention and Control, University of Texas,; M.D. Anderson Hospital, Houston 77030.
There are important reasons for considering nitrite inhalation as a factor in the development of AIDS-related KS in young male homosexuals. These are (1) the pharmacologic properties of amyl, butyl, and isobutyl nitrites, which are toxic; (2) the mutagenic, teratogenic, and carcinogenic products resulting from metabol
Rowley AH; Shulman ST; Preble OT; Poiesz BJ; Ehrlich GD; Sullivan JR; Department of Pediatrics, Northwestern University Medical School,; Children's Memorial Hospital, Chicago, IL 60614.
Wien Klin Wochenschr. 1988 Aug 5;100(15):505-9. Unique Identifier : AIDSLINE MED/89021049
Fuchs D; Hausen A; Reibnegger G; Werner ER; Vinazzer H; Dierich MP; Wachter H; Institute of Medical Chemistry and Biochemistry, University of; Innsbruck.
Various immunological parameters were investigated in 12 children suffering from severe haemophilia A or B receiving substitution therapy over a follow-up period of 3 1/2 years. At the beginning of the study, the therapy was changed to heat-treated concentrates of factors VIII or IX. Antibodies to HIV were found in 9
Ann Neurol. 1988 Aug;24(2):277-9. Unique Identifier : AIDSLINE MED/89024535
Grimaldi LM; Castagna A; Lazzarin A; Pristera R; Bianchi G; Moroni M; Roos RP; Department of Neurology, University of Chicago, IL 60637.
Serum and cerebrospinal fluid (CSF) samples from asymptomatic patients seropositive for human immunodeficiency virus (HIV) showed frequent evidence of intrathecal IgG synthesis and oligoclonal IgG bands, with different isoelectric focusing patterns in serum and CSF; 2 of 7 had a CSF pleocytosis. The results suggest fr
Dalmasso AP; Department of Laboratory Medicine and Pathology, University of; Minnesota, Minneapolis.
Complement is a humoral effector system composed of 21 plasma proteins that was identified initially because of its cytolytic effects. In addition to cytolysis, complement has a number of different functions related to inflammatory and other host defense processes. The description of the reaction mechanism includes: (
Kai C; Okada N; Okada H; Department of Microbiology, Fukuoka University School of; Medicine.
MT-2 cells, which produce human T-cell lymphotropic virus type I (HTLV-I), are known to have a complement receptor. We have established that the complement receptor is CR2 which binds C3d on immune complexes but not CR1. CR2 was also detected on ATL-3I cells but no complement receptor was detected on ATL-1K cells whic
Lau AS; Read SE; Williams BR; Division of Infectious Diseases, Hospital for Sick Children,; Toronto, Ontario, Canada.
Interferons (IFN) elicit antiviral and antineoplastic activities by binding to specific receptors on the cell surface. In evaluating the role of IFN as therapeutic agents in AIDS, we investigated the expression of IFN alpha and gamma receptors on peripheral blood mononuclear cells (PBM) from patients with AIDS, ARC, a
Alessi E; Cusini M; Zerboni R; First Clinic of Dermatology, University of Milan, Italy.
The mucocutaneous manifestations observed in 516 patients infected with human immunodeficiency virus attending an outpatient clinic for acquired immunodeficiency syndrome in Milan, Italy , from July 1985 to March 1987 are listed, and the clinicopathologic aspects of these disorders a
Berger RS; Stoner MF; Hobbs ER; Hayes TJ; Boswell RN; Department of Dermatology, Wilford Hall U.S. Air Force Medical; Center, Lackland Air Force Base, Texas 78236-5300.
After demonstrating antibodies to the human immunodeficiency virus (HIV), two hundred patients were interviewed and given a complete cutaneous and mucous membrane examination. By means of the Walter Reed Staging Classification System for HIV infection, 155 patients were classified as having Walter Reed stage 1A-2A (WR
Of the 1124 human immunodeficiency virus (HIV)-infected patients studied, one or more cutaneous lesions were found in 113 (98.3%) of the 115 patients with acquired immunodeficiency syndrome (AIDS) and in 541 (53.6%) of 1009 patients with AIDS-related complex (ARC). Kaposi s sarcoma, multidermatomal, necrotic herpes zo
Lazzarin A; Negri C; Tambussi G; Saracco A; Galli M; Crocchiolo P; Irato L; Castagna A; Moroni M; Clinic of Infectious Diseases, University of Milan, Italy.
HIV selectively infects T helper lymphocytes, which play an essential role in cell-mediated immunity mechanisms. Impairment of these mechanisms can be evaluated, other than by clinical parameters, by testing lymphocytic subsets and cutaneous delayed type hypersensitivity. All these indices are used in the Walter Reed
Med Hypotheses. 1988 Aug;26(4):229-30. Unique Identifier : AIDSLINE MED/89014025
Vaddadi KS; Das UN; Department of Psychiatry, Crawley Hospital, Crawley, Sussex, U.K.
Prostaglandins and or its precursors are present in certain body fluids. It has been suggested that critical concentrations of PGE are essential for the HIV to penetrate a lymphocyte. Certain clinical implications of this hypothesis have been discussed.
Buffet C; Gagnepain A; Hagege H; Balian P; Espinoza P; Service des Maladies du foie et de l'appareil digestif, Hopital; de Bicetre, Le Kremlin Bicetre.
Infections with the B, D, A, NANB viruses and with the human immunodeficiency virus (HIV) are very common among drug addicts, some of whom may harbour several of these pathogens. The serum of 90 per cent of drug addicts contains one of the HBV markers, and 20 per cent of them carry an anti-D antibody which is more oft
Science. 1988 Oct 28;242(4878):580-3. Unique Identifier : AIDSLINE MED/89019397
Takeda A; Tuazon CU; Ennis FA; Department of Medicine, University of Massachusetts Medical; School, Worcester 01655.
Monocytes and macrophages, which may play a central role in the pathogenesis of infection with human immunodeficiency virus type 1 (HIV-1), express the CD4 molecule and Fc receptors (FcR) for immunoglobulin G (IgG). To explore the possibility that FcR mediate HIV-1 infection of monocytes, studies were conducted with t
Cuneo A; Lanza F; Spanedda R; Tomasi P; Ferrari L; Castoldi GL; Chair of Hematology, University of Ferrara, Italy.
Three patients affected by T helper chronic lymphocytic leukemia were treated with low dose interferon alpha-2b (3 MU/m2 3 times weekly). The disease presented different pathologic expressions with diffuse skin lesions in one patient, a mild clinical course and a prolymphocytic variant with aggressive features, respec
Ganser A; Carlo-Stella C; Bartram CR; Boehm T; Heil G; Henglein B; Muller H; Raghavachar A; von Briesen H; Griesinger F; et al; Department of Hematology, University of Frankfurt, FRG.
To analyze the pathogenesis of B-cell lymphomas in patients with acquired immunodeficiency syndrome (AIDS), we studied two cell lines, Es I and Es III, established from one such lymphoma for the presence of sequences of the Epstein-Barr virus (EBV) and the human immunodeficiency virus [HIV; lymphadenopathy-associated
Wexner SD; Smithy WB; Trillo C; Hopkins BS; Dailey TH; Division of Colon and Rectal Surgery, Roosevelt Hospital, New; York, New York.
The charts of all patients with the acquired immune deficiency syndrome (AIDS) who underwent emergency intra-abdominal surgery between January 1981 and July 1987 were reviewed. Eleven AIDS patients underwent 13 emergency laparotomies. Seven of these patients (64 percent) had cytomegalo
Dtsch Med Wochenschr. 1988 Oct 14;113(41):1588-93. Unique Identifier : AIDSLINE MED/89004600
Heise W; Mostertz P; Arasteh K; Skorde J; L'age M; II. Innere Abteilung (Infektiologie und Gastroenterologie),; Auguste-Viktoria-Krankenhaus, Berlin-Schoneberg.
Among 200 hospitalized patients treated for HIV infections there were 98 with gastrointestinal symptoms, independent of the stage of the disease. Only 22 had abnormal stool findings. But histological examination and culture of endoscopically obtained biopsies revealed opportunistic infection in 62, of whom 28 had a
Eur Respir J. 1988 Jun;1(6):553-7. Unique Identifier : AIDSLINE MED/89005587
Chanez P; Aubas P; Segondy M; Barneon G; Cluzel M; Maria Y; Mandin J; Michel FB; Godard P; Service des Maladies Respiratoires, Hopital de l'Aiguelongue,; Montpellier, France.
Pneumonopathic conditions in the immunocompromised host (IH) are frequent and often serious. Rapid diagnosis is essential and is made possible by bronchoalveolar lavage (BAL). Sixty-two pneumonopathic episodes in 53 immunocompromised patients were examined by BAL, for viral cytopathogenic effects (CPE) in isolated cel
Itin P; Rufli T; Rudlinger R; Cathomas G; Huser B; Podvinec M; Gudat F; Department of Dermatology, University of Basel, Switzerland.
We report the case of a 58-year-old renal transplant patient who developed oral hairy leukoplakia. Examination for HIV-1 and HIV-2 infection was negative. Biopsy of the lateral tongue showed ballooned prickle cells and electron microscopy revealed herpes-type viruses. In situ hybridization and examinations with the So
Fujisawa J; Seiki M; Toita M; Miyatake S; Arai K; Yoshida M; Department of Viral Oncology, Cancer Institute, Tokyo, Japan.
A transcriptional trans-activator p40tax of HTLV-1 was reported to activate HTLV-1 enhancer, but not SV40 or Rous sarcoma virus enhancer. However, in certain cell lines, we found that SV40 enhancer was activated by p40tax. These cell lines were mostly T cells, where the SV40 enhancer showed only low activity without p
Giam CZ; Boros I; Department of Biochemistry, University of Nebraska Medical; Center, College of Medicine, Omaha.
The viral-specific protease of human immunodeficiency virus (HIV) has been expressed as a lacZ-protease fusion protein. This fusion protein contains protease cleavage sites at the gag/protease and protease/reverse transcriptase junctions and undergoes autoprocessing in vivo when expressed in Escherichia coli. The puri
Hierholzer JC; Wigand R; Anderson LJ; Adrian T; Gold JW; Respiratory and Enteric Viruses Branch, Centers for Disease; Control, Atlanta, Georgia 30333.
We analyzed 67 adenovirus isolates from 48 patients with AIDS. The isolates included 5 of subgenus A (all Ad31), 23 of subgenus B, 4 of subgenus C (all Ad5), and 35 of subgenus D. The subgenus A and C strains were from liver, lung, blood, urine, and stool and were unremarkable in their antigenic characteristics. The s
Perno CF; Yarchoan R; Cooney DA; Hartman NR; Gartner S; Popovic M; Hao Z; Gerrard TL; Wilson YA; Johns DG; et al; Clinical Oncology Program, National Cancer Institute, Bethesda,; Maryland 20892.
Because of the probable role of HIV-infected monocyte/macrophages in the pathogenesis and progression of AIDS, it is essential that antiretroviral therapy address viral replication in cells of this lineage. Several dideoxynucleosides have been shown to have potent in vitro and, in the case of 3 -azido-2 ,3 -dideoxythy
J Med Virol. 1988 Jul;25(3):339-49. Unique Identifier : AIDSLINE MED/89010717
Jacobson MA; O'Donnell JJ; Brodie HR; Wofsy C; Mills J; Department of Medicine, University of California San Francisco.
We report the first randomized prospective comparative study of long-term maintenance ganciclovir (9-[2-hydroxy-1-(hydroxymethyl)ethoxymethyl]guanine, BW759U, DHPG) therapy for cytomegalovirus retinitis in patients with the acquired immunodeficiency syndrome (AIDS). Eleven retiniti
Gimble JM; Duh E; Ostrove JM; Gendelman HE; Max EE; Rabson AB; Laboratory of Immunogenetics, National Institute of Allergy and; Infectious Diseases, Bethesda, Maryland 20892.
It has been previously shown that herpes simplex virus type 1 (HSV-1) infection of HeLa cells results in augmentation of gene expression directed by the human immunodeficiency virus (HIV) long terminal repeat (LTR). This effect is presumably mediated by protein interactions with the LTR. We have used two different ass
Skinner MA; Langlois AJ; McDanal CB; McDougal JS; Bolognesi DP; Matthews TJ; Department of Surgery, Duke University Medical Center, Durham,; North Carolina 27710.
Animals immunized with the human immunodeficiency virus type 1 gp160 glycoprotein or certain recombinant envelope components develop potent virus-neutralizing activity. This activity is principally due to antibodies directed toward a hypervariable region of gp120 between cysteine residues 302 and 337 and is virus isol
Koka P; Yunis J; Passarelli AL; Dubey DP; Faller DV; Ynis EJ; Division of Pediatric Oncology, Dana-Farber Cancer Institute,; Massachusetts 02115.
The tat gene of the human immunodeficiency virus, tat-III, when introduced into T-lymphoblastoid Jurkat cells by a Moloney retroviral recombinant DNA vector expressed high levels of the functional tat protein as measured by the chloramphenicol acetyltransferase assay. Immunofluorescence analysis with CD4-specific mono
Med J Aust. 1988 Oct 3;149(7):368-73. Unique Identifier : AIDSLINE MED/89014093
Whyte BM; Cooper DA; NHMRC Special Unit in AIDS Epidemiology and Clinical Research,; University of New South Wales.
In 1982, one year after the first cases of the acquired immunodeficiency syndrome (AIDS) were reported, a case definition of AIDS was produced by the Centers for Disease Control, Atlanta, Georgia, USA. This definition was implemented world-wide, and it allowed the standardization of the reporting of cases. The identif
Nussenblatt R; National Eye Institute, Bethesda, Md.
The acquired immunodeficiency syndrome (AIDS) affects the ocular structures in several ways. Kaposi s sarcoma has been observed on the bulbar conjunctiva of the globe. Retinal complications, however, are of major concern. Cotton-wool spots are commonly seen in AIDS patients and are usually of no consequence, except th
Miller RG; Parry GJ; Pfaeffl W; Lang W; Lippert R; Kiprov D; Department of Neurology, Children's Hospital, San Francisco, CA; 94119.
Peripheral neuropathy is increasingly recognized as a complication of the Acquired Immune Deficiency Syndrome (AIDS) and AIDS-related complex (ARC), but the varied clinical features have been incompletely described. Thirty homosexual men with peripheral neuropathy wer
Nature. 1988 Oct 13;335(6191):606-11. Unique Identifier : AIDSLINE MED/89014720
Vogel J; Hinrichs SH; Reynolds RK; Luciw PA; Jay G; Laboratory of Molecular Virology, National Cancer Institute,; Bethesda, Maryland 20892.
When the human immunodeficiency virus transactivating gene under the control of the viral regulatory region is introduced into the germline of mice, skin lesions are induced that resemble Kaposi s sarcoma seen in AIDS. Our findings indicate that HIV could play a direct part in causing cancer.
Nature. 1988 Oct 13;335(6191):639-42. Unique Identifier : AIDSLINE MED/89014725
Brenneman DE; Westbrook GL; Fitzgerald SP; Ennist DL; Elkins KL; Ruff MR; Pert CB; Laboratory of Developmental Neurobiology, National Institute of; Child Health and Human Development, Bethesda, Maryland 20892.
The clinical manifestations of AIDS (acquired immune deficiency syndrome) often include neuropsychiatric and neurological deficits, including early memory loss and progressive dementia . HIV (human immunodeficiency virus), the aetiological agent of AIDS, is probably carried by infec
Ussery FM 3d; Gibson SR; Conklin RH; Piot DF; Stool EW; Conklin AJ; Special Diseases Service, Park Plaza Hospital, Houston, TX.
Ganciclovir (BW B759U, DHPG, dihydroxy propoxymethyl guanine) was injected directly into the vitreous in 14 eyes of 11 patients with severe acquired immune deficiency syndrome (AIDS)-associated cytomegalovirus ( CMV ) retinitis
Egberink H; Ederveen J; Koolen M; Lutz H; Horzinek MC; Afdeling Virologie, Vakgroep Infectieziekten en Immunologie,; Faculteit Diergeneeskunde, Rijks-universiteit Utrecht.
A new retrovirus was recently discovered in cats affected with an immunodeficiency syndrome (AIDS). The virus shows morphological and biological similarities with the human immunodeficiency virus (HIV), which causes AIDS in human individuals. As the T-lymphocyte is the primary target of the virus, it is termed Feline
Tijdschr Diergeneeskd. 1988 Oct 1;113(19):1063-4. Unique Identifier : AIDSLINE MED/89020035
Weijer K; van Herwijnen R; Siebelink K; UytdeHaag F; Osterhaus A; Nederlands Kanker Instuut, Amsterdam.
The prevalence in the Netherlands and the Free Republic of Germany (FRG) of the newly discovered retrovirus of cats, which causes an immunodeficiency syndrome in this species and is termed feline T-lymphotropic lentivirus (FTLV), was estim
Wiley CA; Grafe M; Kennedy C; Nelson JA; Department of Pathology, University of California, San Diego,; School of Medicine, La Jolla 92093.
Of the 93 acquired immune deficiency syndrome (AIDS) patients autopsied between 1983 and 1986, 27 had evidence of viral encephalitis of which 3 had progressive multifocal leukoencephalopathy (PML), confirmed by electron microscopy. Using in situ hybridization with biotinylated JC virus probes, paraffin sections from t
Am J Med. 1988 Oct;85(4):477-80. Unique Identifier : AIDSLINE MED/89023163
Stern JJ; Hartman BJ; Sharkey P; Rowland V; Squires KE; Murray HW; Graybill JR; Division of Infectious Diseases, Cornell University Medical; College, New York, New York.
PURPOSE: Cryptococcus neoformans causes infections in up to 10 percent of patients with the acquired immunodeficiency syndrome (AIDS). Nearly 50 percent of AIDS patients with previously treated cryptococcal meningitis will experience a relapse within six months. To reduce the likelihood of relapse, a maintenance regim
Am J Med. 1988 Oct;85(4):481-9. Unique Identifier : AIDSLINE MED/89023164
Sugar AM; Saunders C; Evans Memorial Department of Clinical Research, Boston University; Medical Center, Massachusetts.
PURPOSE: Because of the increasing numbers of patients with acquired immunodeficiency syndrome (AIDS) who will require treatment for cryptococcosis and because of the problems associated with long-term administration of intravenous amphotericin B, an alternative therapeutic approach in the form of an efficacious and e
Am J Pathol. 1988 Oct;133(1):73-81. Unique Identifier : AIDSLINE MED/89023471
Wiley CA; Nelson JA; Department of Pathology, University of California, San Diego.
Approximately half of patients with advanced acquired immune deficiency syndrome (AIDS) develop a subcortical dementia . The brains of all autopsies on AIDS patients performed at UCSD between 1982 and 1986 (N = 93) were studied. Neuropathologic changes consistent with a viral enceph
Lange DJ; Britton CB; Younger DS; Hays AP; Department of Neurology, College of Physicians and Surgeons,; Columbia University, New York, NY.
We studied 14 patients with neuromuscular disorders and concomitant infection with human immunodeficiency virus to define clinical syndromes and prognosis. Eight patients had painful sensorimotor peripheral neuropathy ; two, chronic inflammatory demyelinating polyneuro
Jacobson MA; Mills J; Rush J; O'Donnell JJ; Miller RG; Greco C; Gonzales MF; Department of Medicine, University of California, San Francisco.
We report the first published case (to our knowledge) of histopathologically documented acquired immunodeficiency syndrome-related cytomegalovirus ( CMV ) myelitis in which antiviral drug therapy was administered. Despite sensi
Biochem J. 1988 Sep 1;254(2):599-603. Unique Identifier : AIDSLINE MED/89025735
Mizuochi T; Spellman MW; Larkin M; Solomon J; Basa LJ; Feizi T; Section of Glycoconjugate Research, Medical Research Council; Clinical Research Centre, Harrow, Middx., U.K.
The present paper describes the structures of the N-linked oligosaccharides of the human-immunodeficiency-virus (HIV) envelope glycoprotein gp120 (cloned from the HTLV-III B isolate and expressed as a secreted fusion protein after transfection of Chinese-hamster ovary cells), which is known to bind with high affinity
Sugano T; Masuho Y; Matsumoto Y; Lake D; Gschwind C; Petersen EA; Hersh EM; Teijin Institute for Biomedical Research, Tokyo, Japan.
We have established a program to make human monoclonal antibodies to the human immunodeficiency virus (HIV). Lymphocytes of lymph nodes from patients with the acquired immunodeficiency syndrome (AIDS) related complex (ARC) spontaneously produced antibodies to HIV in vitro and their antibody production was suppressed b
Malkovsky M; Philpott K; Dalgleish AG; Mellor AL; Patterson S; Webster AD; Edwards AJ; Maddon PJ; MRC Clinical Research Centre, Harrow, Middlesex, GB.
The T4 molecule (CD4) is an important component of the human immunodeficiency virus (HIV) receptor. As yet, no other component has been demonstrated. We report here that two cell lines, a B lymphoblastoid cell line (Gupta) and a glial cell line (HEB) derived from human embryonal brain tissue, are productively infectab
Rousell RH; Cutter Biological, Miles Inc., Berkeley, CA 94701.
Although rare, side-effects have been associated with the administration of iv immune globulins (IVIG). While the clinical presentation may be similar, several different mechanisms account for these adverse reactions. There are those effects in the hypogammaglobulinaemic patient which are probably due to antigen-antib
Yap PL; Williams PE; Edinburgh and South East Scotland Blood Transfusion Service.
The main immunological abnormality described in patients with the acquired immunodeficiency syndrome (AIDS) is the deficiency in cellular immunity. However, there is increasing evidence of a deficiency of specific antibody synthesis in both symptomatic human immunodeficiency virus (HIV)-infected children and in some H
Williams PE; Hague RA; Yap PL; Mok J; Brettle RP; Coutts NA; Eden OB; Watson JG; Blood Transfusion Centre, Royal Infirmary, Edinburgh, UK.
Five human immunodeficiency virus (HIV) antibody positive children developed recurrent infections requiring multiple hospital admissions. These comprised mainly upper respiratory tract infections, otitis media, pneumonia and diarrhoea, and there was failure to thrive despite adequate antibiotic therapy. They were comm
J Med Virol. 1988 Aug;25(4):371-85. Unique Identifier : AIDSLINE MED/89010720
Buimovici-Klein E; Lange M; Ong KR; Grieco MH; Cooper LZ; Department of Pediatrics, St. Luke's-Roosevelt Hospital Center,; New York, NY 10019.
Virus shedding was detected in 77% of homosexual subjects and in only 6% of heterosexual controls. The overall virus isolation rate in homosexual subjects was not significantly different among HIV-seropositive (79%) and HIV-seronegative (74%) individuals. In about 20% of homosexual subjects, virus shedding from multip
Lancet. 1988 Oct 8;2(8615):814-6. Unique Identifier : AIDSLINE MED/89013402
32 patients with coagulation factor deficiencies and likely to be susceptible to non-A, non-B hepatitis (NANBH) virus infection were treated with a total of 20 batches of a factor VIII concentrate and 10 batches of a factor IX concentrate, both heated at 80 degrees C for 72 h in the freeze-dried state. Serial measurem
Lancet. 1988 Oct 15;2(8616):887-90. Unique Identifier : AIDSLINE MED/89013463
Ngugi EN; Plummer FA; Simonsen JN; Cameron DW; Bosire M; Waiyaki P; Ronald AR; Ndinya-Achola JO; Centre for Microbiology Research, Kenya Medical Research; Institute, Nairobi.
Condom use was assessed after a programme of education about the acquired immunodeficiency syndrome and a condom distribution programme in a well-characterised prostitute population in Nairobi. Women received their education at group meetings (barazas) and at individual counselling sessions during which they were give
Lancet. 1988 Oct 22;2(8617):927-30. Unique Identifier : AIDSLINE MED/89013518
Tedder RS; O'Connor T; Hughes A; N'jie H; Corrah T; Whittle H; Department of Medical Microbiology, University College and; Middlesex School of Medicine, London.
Serological identification of infection with human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2) by western blot alone may not be sufficient to diagnose dual infection. Extensive cross-reactions (eg, to envelope glycoprotein antibody) are seen on heterologous western blots. The use of other techniques, in thi
Lancet. 1988 Oct 22;2(8617):947-9. Unique Identifier : AIDSLINE MED/89013527
Ohi G; Terao H; Hasegawa T; Hirano W; Kai I; Kobayashi Y; Inaba Y; Muramatsu Y; Miyama T; Ashizawa M; et al; Department of Environmental and Community Medicine, Teikyo; University School of Medicine, Tokyo, Japan.
Passing of the AIDS Prevention Bill, which demands the notification of human immunodeficiency virus (HIV) carriers, seems imminent in Japan . Its effect on people s willingness to be tested for the HIV antibody was assessed among heterosexual subjects (students, office workers) and g
Ann Neurol. 1988 Aug;24(2):275-7. Unique Identifier : AIDSLINE MED/89024534
Said G; Goulon-Goeau C; Lacroix C; Feve A; Descamps H; Fouchard M; Service de Neurologie, Hopital de Bicetre (Universite Paris; XI), France.
In a patient with tropical spastic paraparesis associated with a positive titer for human T-lymphotropic virus type I, electrophysiological study detected a mixed, axonal and demyelinating, multifocal neuropathy. Perineural and perivascular infiltrates, moderate axon loss, wallerian degeneration, and demyelinating les
Ann Neurol. 1988 Aug;24(2):280-2. Unique Identifier : AIDSLINE MED/89024536
Mori M; Kinoshita K; Ban N; Yamada Y; Shiku H; Division of Internal Medicine, Nagasaki-Chuo National Hospital,; Japan.
Human T-lymphotropic virus type I (HTLV-I)--associated myelopathy (HAM) has been shown to be closely related to HTLV-I infection. However, the mechanism by which this disease occurs after infection with HTLV-I is still obscure. We found that HAM patients have unusually high proportions of CD4+ HLA-DR+ cells, CD8+HLA-D
Diven DG; Newton RC; Ramsey KM; Department of Dermatology, University of Texas Medical Branch,; Galveston.
Three patients with acquired immunodeficiency syndrome noted changing cutaneous reactions to mosquito bites one to three months after starting zidovudine therapy. Enhanced T-cell function is one possibility for the heightened response to mosquito bites in these patients.
Vazquez-Iglesias JL; Yanez J; Durana J; Arnal F; Gastroenterology Unit, Hospital Juan Canalejo, La Coruna, Spain.
We report the case of a 24-year-old woman who presented with diarrhea, weight loss and abdominal lymph node enlargement. A diagnosis of infection by Mycobacterium avium intracellulare with a clinical picture similar to Whipple s disease was established. The endoscopic study of the duodenum revealed multiple yellow nod
FEBS Lett. 1988 Oct 10;238(2):257-61. Unique Identifier : AIDSLINE MED/89005695
Sakai K; Ma XY; Volsky DJ; Molecular Virology Laboratory, St. Luke's/Roosevelt Hospital; Center, College of Physicians & Surgeons, Columbia University,; New York, NY 10019.
Single genotypic variants of HIV-I, contained in a parental cytopathic HIV-I isolate, were isolated by molecular cloning and propagated in susceptible cells. Two such HIV-I clones, designated N1T-E and N1T-A, exhibited similar restriction endonuclease maps but strikingly different biological activities. Infection of T
Majumdar C; Abbotts J; Broder S; Wilson SH; Laboratory of Biochemistry, National Cancer Institute, Bethesda,; Maryland 20892.
A study of steady-state kinetics of polymerization by purified human immunodeficiency virus DNA polymerase (reverse transcriptase) has been conducted. DNA synthesis was examined using a system of poly(rA) as template, oligo(dT) as primer, and dTTP as nucleotide substrate. The substrate initial velocity patterns point
Langlade-Demoyen P; Michel F; Hoffenbach A; Vilmer E; Dadaglio G; Garicia-Pons F; Mayaud C; Autran B; Wain-Hobson S; Plata F; Laboratoire de Biologie et d'Immunologie Moleculaires des; Retrovirus, Institut Pasteur, Paris, France.
The CTL response to HIV was analyzed in humans and in mice. By using a novel and strictly autologous lymphocyte culture system, human CTL lines were established with PBL from seropositive asymptomatic donors and from patients suffering from AIDS or presenting AIDS-related complex. CTL from HLA-A2 donors recognize and
Yoshimura N; Nakamura H; Honjo S; Akiyama N; Hayami M; Department of Animal Pathology, Tokyo University, Japan.
The cell-mediated killer activity in cynomolgus monkeys, which were infected 2.5 yr previously with HTLV-1, was examined. With HTLV-1-infected autologous lymphoid cells as targets, HTLV-1-specific killer cells were not detected among PBL cells of infected monkeys, but in monkeys in which specific memory cells were fou
Hockley DJ; Wood RD; Jacobs JP; Garrett AJ; Electron Microscopy and Photography Section, National Institute; for Biological Standards and Control, Potters Bar, Hertfordshire,; U.K.
Two cell lines of human T lymphocytes (H9 and CEM) chronically infected with isolates of human or simian immunodeficiency viruses were examined by electron microscopy. Scanning electron microscopy of H9 cells showed characteristic morphological changes in the cells after infection with human T cell lymphotropic virus
Whealy ME; Baumeister K; Robbins AK; Enquist LW; Central Research and Development Department, E.I. du Pont de; Nemours & Co., Inc., Wilmington, Delaware 19898.
We describe experiments using the swine herpesvirus, pseudorabies virus (PRV), as a vector for expression of hybrid membrane protein genes. In particular, we present the construction and analysis of three infectious PRV mutants expressing chimeric viral membrane proteins composed of portions of the PRV envelope glycop
Fenyo EM; Morfeldt-Manson L; Chiodi F; Lind B; von Gegerfelt A; Albert J; Olausson E; Asjo B; Department of Virology, Karolinska Institutet, Stockholm, Sweden.
According to their capacity to replicate in vitro, human immunodeficiency virus (HIV) isolates can be divided into two major groups, rapid/high and slow/low. Rapid/high viruses can easily be transmitted to a variety of cell lines of T-lymphoid (CEM, H9, and Jurkat) and monocytoid (U937) origin. In contrast, slow/low v
Hao Z; Cooney DA; Hartman NR; Perno CF; Fridland A; DeVico AL; Sarngadharan MG; Broder S; Johns DG; Developmental Therapeutics Program, National Cancer Institute,; Bethesda, Maryland 20892.
Mitsuya and Broder [Proc. Natl. Acad. Sci. USA 83:1911-1915 (1986)] demonstrated that every purine (adenosine, guanosine, and inosine) and pyrimidine (cytidine and thymidine) nucleoside containing the 2 ,3 -dideoxyribose configuration, when evaluated against human immunodeficiency virus (HIV) in vitro, significantly s
Science. 1988 Oct 21;242(4877):430-3. Unique Identifier : AIDSLINE MED/89019376
Salahuddin SZ; Nakamura S; Biberfeld P; Kaplan MH; Markham PD; Larsson L; Gallo RC; Laboratory of Tumor Cell Biology, National Cancer Institute,; Bethesda, MD 20892.
Cells derived from lung biopsies and pleural effusions from AIDS patients with Kaposi s sarcoma (KS) of the lungs were established in long-term culture with the aid of conditioned medium from HTLV-II-transformed T cells (HTLV-II CM). These AIDS-KS cells were similar to the so-called spindle cells in KS lesions and had
Flexner C; Broyles SS; Earl P; Chakrabarti S; Moss B; Laboratory of Viral Diseases, National Institute of Allergy and; Infectious Diseases, Bethesda, Maryland 20892.
Recombinant vaccinia viruses containing either the entire gag/pol gene or the reverse transcriptase (RT) domain of the human immunodeficiency virus (HIV) were constructed. In mammalian cells infected with the recombinant vaccinia virus containing the gag/pol gene, major and minor polypeptides of 55 and 41 kDa were mad
World Health Stat Q. 1988;41(2):82-102. Unique Identifier : AIDSLINE MED/89021088
Causse G; Meheus A; Service des infections bacteriennes et veneriennes Division; des maladies transmissibles, Organisation mondiale de la Sante,; Geneve.
From the moment WHO was established in 1948, the control of venereal diseases was felt to deserve highest priority, together with activities to control malaria and tuberculosis. International action was needed in view of the high morbidity and mortality from venereal diseases, their serious human and social consequenc
Am J Vet Res. 1988 Aug;49(8):1246-58. Unique Identifier : AIDSLINE MED/89024155
Yamamoto JK; Sparger E; Ho EW; Andersen PR; O'Connor TP; Mandell CP; Lowenstine L; Munn R; Pedersen NC; Department of Medicine, School of Veterinary Medicine, University; of California, Davis 95616.
Feline immunodeficiency virus (FIV; formerly, feline T-lymphotropic lentivirus) is a typical lentivirus resembling human and simian immunodeficiency viruses in morphologic features, protein structure, and reverse transcriptase enzyme. It is antigenically dissimilar, however. The virus is tropic for primary and permane
Kaltoft K; Bisballe S; Rasmussen HF; Thestrup-Pedersen K; Boehncke WH; Volker H; Sterry W; Department of Dermatology, University of Aarhus, Denmark.
Se-Ax is a continuous mature T-cell line that we have established from a patient with Sezary s syndrome. An important finding was that the Se-Ax cell line required human serum for initial growth. Here we show that transfer of the permanent cell line to a medium deficient of human serum induces production of C-type ret
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