IMMUNOBIOLOGY OF HODGKIN'S DISEASE AND NON-HODGKIN'S LYMPHOMA NLM AIDSLINE Important note: Information in this article was accurate in 1989. The state of the art may have changed since the publication date.

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IMMUNOBIOLOGY OF HODGKIN'S DISEASE AND NON-HODGKIN'S LYMPHOMA

Hodgkin's Disease and Non-Hodgkin's Lymphomas in Adults and Children. Fuller LM et al, eds. New York, Raven, p. 47-88, 1988.. Unique Identifier : AIDSLINE ICDB/89649505
Ford RJ Jr; Mehta SR; Sharma S; Dept. of Pathology, Univ. of Texas M.D. Anderson Hosp. and Tumor; Inst., Houston, TX 77030

Abstract: The immunobiology of Hodgkin's disease (HD) and non-Hodgkin's lymphoma (NHL) is reviewed; and the normal human T-cell, B-cell, and monocyte/macrophage systems are described. Topics include morphology and immunopathologic description of HD (nature of the malignant cell, T-cell regulation in HD), morphologic and immunopathologic analyses of cell types in NHL (conventional immunologic markers, monoclonal antibodies for immunophenotyping NHL, control of cell proliferation in neoplastic human lymphoid cells, in vitro cultivation of NHL cells and other neoplastic lymphoid cells, and role of growth factors in neoplastic lymphoid cell growth), the role of oncogenic viruses in human lymphoid neoplasia (Epstein-Barr virus, human retroviruses), and molecular biology of human lymphoid neoplasms (Ig and T-cell receptor gene rearrangements, expression of oncogenes in human lymphoid neoplasms, and proto-oncogenes and human lymphoid neoplasms). Monoclonal antibody techniques currently form the basis for identifying these neoplastic lesions in conjunction with classic histopathologic descriptive morphology. Molecular biology and the application of its techniques for solving fundamental biologic questions, in concert with the continued contributions of immunopathology and molecular virology, appear to hold the key to an in-depth understanding of lymphoid neoplasia. This, in turn, should lead to new and more efficient therapeutic strategies, perhaps through biologic response modification. (161 Refs)
Keywords: B-Lymphocytes/IMMUNOLOGY Cell Transformation, Viral Hodgkin's Disease/GENETICS/*IMMUNOLOGY/PATHOLOGY Human HTLV-BLV Viruses/GENETICS Immune Tolerance Lymph Nodes/PATHOLOGY Lymphoma, Non-Hodgkin's/GENETICS/*IMMUNOLOGY/PATHOLOGY Macrophages/IMMUNOLOGY Monocytes/IMMUNOLOGY Oncogenes T-Lymphocytes/IMMUNOLOGY Tumor Cells, Cultured/IMMUNOLOGY MONOGRAPH REVIEW, ACADEMIC REVIEW

KWDb-lymphocytes/immunologycelltransformation,viralhodgkin'sdisease/genetics/KWDimmunology/pathologyhumanhtlv-blvviruses/geneticsimmunetolerancelymphnodes/pathologylymphoma,non-hodgkin's/genetics/KWDimmunology/pathologymacrophages/immunologymonocytes/immunologyoncogenest-lymphocytes/immunologytumorcells,cultured/immunologymonographreview,academicreview
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Copyright © 1989 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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