Important note: Information in this article was accurate in 1989. The state of the art may have changed since the publication date.
THE CLINICAL AND PATHOLOGIC SPECTRUM OF PERIPHERAL T CELL LYMPHOMAS
Hodgkin's Disease and Non-Hodgkin's Lymphomas in Adults and Children. Fuller LM et al, eds. New York, Raven, p. 381-401, 1988.. Unique Identifier : AIDSLINE ICDB/89649521 Riggs SA; Hagemeister FB; Dept. of Hematology, Univ. of Texas M.D. Anderson Hosp. and Tumor; Inst., Houston, TX 77030
Abstract:
The various types of T-cell malignancies are reviewed and distinguished from one another, with an emphasis on clinical features and the treatment of patients with peripheral T-cell lymphoma, including adult T-cell leukemia-lymphoma. Variously described pathologic entities, probably variants of peripheral T-cell lymphoma, are discussed in relation to differential diagnosis of peripheral T-cell lymphoma. Diagnosis of peripheral T-cell lymphoma also is discussed as it relates to the Working Formulation, a classification that does not recognize any clinical differences between B-cell and T-cell lymphomas. Disease entities discussed are lymphoblastic lymphoma, mycosis fungoides and the Sezary syndrome, T-gamma lymphoproliferative disease, T-cell chronic lymphocytic leukemia, and peripheral T-cell lymphoma. The Working Formulation uses the Lukes-Collins terminology, which describes the appearance of tumor cells based on size and presence or absence of a cleaved nucleus, to classify lymphomas as diffuse small cleaved cell lymphoma, diffuse mixed cell lymphoma, diffuse large cell lymphoma, or immunoblastic sarcoma. The most important aspect of managing peripheral T-cell lymphoma is the establishment of the correct diagnosis. Besides correctly classifying the lymphoma within the confines of the Working Formulation, the pathologist should note that the diagnosis is compatible with peripheral T-cell lymphoma when epithelioid histiocytes are present and there is no evidence of a follicular component. Marker studies are essential when the lymphoma has a diffuse morphologic pattern to rule out B-cell lymphoma, even when the morphologic appearance suggests a T-cell lymphoma. (115 Refs)
Keywords: Diagnosis, Differential DNA, Neoplasm/GENETICS Granuloma, Lethal Midline/PATHOLOGY Human Immunoblastic Lymphadenopathy/PATHOLOGY Leukemia-Lymphoma, T-Cell, Acute, HTLV-I-Associated/PATHOLOGY Leukemia, Lymphocytic, Chronic/PATHOLOGY Lymph Nodes/PATHOLOGY Lymphoma, Non-Hodgkin's/GENETICS/*PATHOLOGY Lymphomatoid Granulomatosis/PATHOLOGY Lymphoproliferative Disorders/PATHOLOGY Mycosis Fungoides/PATHOLOGY Sezary Syndrome/PATHOLOGY Skin Neoplasms/PATHOLOGY T-Lymphocytes/PATHOLOGY MONOGRAPH REVIEW REVIEW, TUTORIAL
AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.
Important note: Information in this article was accurate in 1989. The state of the art may have changed since the publication date.
