Maternally induced graft-vs-host disease to minor antigens as a possible etiology of an acquired immunodeficiency syndrome in mice. NLM AIDSLINE Important note: Information in this article was accurate in 1989. The state of the art may have changed since the publication date.

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Maternally induced graft-vs-host disease to minor antigens as a possible etiology of an acquired immunodeficiency syndrome in mice.

Cancer Detect Prev. 1988;12(1-6):205-10. Unique Identifier : AIDSLINE MED/89028461
Hamilton MS; Becker J; Hamilton BL; Department of Biological Structure, University of Washington,; Seattle.

Abstract: It has been postulated that an acquired immunodeficiency syndrome develops in neonates as the result of a maternally induced graft-vs-host disease (GVHD) that develops when sufficient numbers of maternal lymphocytes are transferred to the fetus across the placental barrier. The present study was done to determine whether major histocompatibility complex (MHC) antigens or non-MHC minor histocompatibility antigens (MiHA) were involved. Female C57BL/6 mice were bred to males of eight selected strains such that maternal-fetal disparity existed at MHC antigens and/or minor histocompatibility antigens. Offspring were tested for immune function at 6-7 weeks of age using a Jerne plaque assay to measure the humoral response to that T dependent antigen sheep red blood cells (SRBC). None of the offspring developed clinical signs of GVHD, but 3 of 124 mice tested made no immune response to SRBC. Immunodeficiency was associated with maternal-fetal disparity only at a small number of MiHA and not at the MHC. We postulate that immunodeficiency in this model is mediated by a subclinical maternally induced GVHD to paternally derived MiHA of the fetus.
Keywords: Acquired Immunodeficiency Syndrome/*ETIOLOGY Animal Female Graft vs Host Disease/*IMMUNOLOGY *Immunity, Maternally-Acquired *Major Histocompatibility Complex Male Maternal-Fetal Exchange Mice Mice, Inbred C57BL *Minor Histocompatibility Loci Pregnancy Support, Non-U.S. Gov't Support, U.S. Gov't, Non-P.H.S. Support, U.S. Gov't, P.H.S. JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/KWDetiologyanimalfemalegraftvshostdisease/KWDimmunologyKWDimmunity,maternally-acquiredKWDmajorhistocompatibilitycomplexmalematernal-fetalexchangemicemice,inbredc57blKWDminorhistocompatibilitylocipregnancysupport,non-uKWDsKWDgov'tsupport,uKWDsKWDgov't,non-pKWDhKWDsKWDsupport,uKWDsKWDgov't,pKWDhKWDsKWDjournalarticle
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Copyright © 1989 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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