Predominance of the IgG1 subclass in the hypergammaglobulinemia observed in pre-AIDS and AIDS. NLM AIDSLINE Important note: Information in this article was accurate in 1989. The state of the art may have changed since the publication date.

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Predominance of the IgG1 subclass in the hypergammaglobulinemia observed in pre-AIDS and AIDS.

Cancer Detect Prev. 1988;12(1-6):211-6. Unique Identifier : AIDSLINE MED/89028462
Kekow J; Hobusch G; Gross WL; Department of Internal Medicine, Christian Albrecht University,; Kiel, Federal Republic of Germany.

Abstract: In addition to the well-known T-cell dysfunctions in AIDS, hypergammaglobulinemia, mostly IgG, and autoimmune phenomena indicate that B cells are also involved. Reports of HIV-infected and activated B cells suggest T cell-independent B-cell abnormalities. In order to assess the IgG subclasses involved in hypergammaglobulinemia, we examined all four IgG subclasses in sera and in vitro with an enzyme-linked immunosorbent assay (ELISA). The in vitro studies included 7-day cultures of mononuclear cells and highly purified B cells stimulated with a T cell-independent polyclonal B-cell activator (Klebsiella pneumoniae, KlebsM). Cultures were done with cells from seven patients with AIDS, seven patients with persistent generalized lymph node enlargement and HIV antibodies, and normal controls. In vivo, hypergammaglobulinemia was found to be restricted to the IgG1 subclass. In vitro, high spontaneous levels of IgG were not elevated significantly under stimulatory conditions, as demonstrated by the measurement of all four IgG subclasses in the culture supernatants. In vitro, hypergammaglobulinemia also resulted from IgG1. These results indicate that there are B-cell abnormalities in pre-AIDS and AIDS, in that the B-cell preactivation in vivo resulting in hypergammaglobulinemia is restricted to IgG1.
Keywords: Acquired Immunodeficiency Syndrome/COMPLICATIONS/*IMMUNOLOGY AIDS-Related Complex/COMPLICATIONS/*IMMUNOLOGY Enzyme-Linked Immunosorbent Assay Homosexuality Human Hypergammaglobulinemia/COMPLICATIONS/*IMMUNOLOGY IgG/*ANALYSIS Male Support, Non-U.S. Gov't JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/complications/KWDimmunologyaids-relatedcomplex/complications/KWDimmunologyenzyme-linkedimmunosorbentassayhomosexualityhumanhypergammaglobulinemia/complications/KWDimmunologyigg/KWDanalysismalesupport,non-uKWDsKWDgov'tjournalarticle
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Copyright © 1989 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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