Lymphadenopathy in HIV (HTLV-III/LAV) infected subjects: the role of virus and follicular dendritic cells. NLM AIDSLINE Important note: Information in this article was accurate in 1989. The state of the art may have changed since the publication date.

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Lymphadenopathy in HIV (HTLV-III/LAV) infected subjects: the role of virus and follicular dendritic cells.

Cancer Detect Prev. 1988;12(1-6):217-24. Unique Identifier : AIDSLINE MED/89028463
Biberfeld P; Porwit A; Biberfeld G; Harper M; Bodner A; Gallo R; Department of Pathology, Karolinska Institute, Stockholm, Sweden.

Abstract: Studies of human immunodeficiency virus (HIV) associated lymphadenopathy by histopathology and immunopathology showed conspicuous changes of follicular B-cell areas from a marked hyperplasia to complete involution. Immunohistochemistry showed a corresponding increase in follicular dendritic reticulum cells (FDRC) followed by progressive destruction of these cells during involution, concomitant with invasion of follicles by T-cells. HIV gag antigens were predominantly associated with FDRC in hyperplastic follicles and diminished during involution. Virus replication was by in situ hybridization seen predominantly in follicles, presumably reflecting productive infection of CD4+ cells and/or FDRC. It is concluded that local effects of the virus play an important role in HIV lymphadenopathy. The marked cytopathogenic effects on FDRC indicate that HIV infection with lymphadenopathy represents not only a disease of CD4+ cells but also of follicular antigen presenting cells (FDRC).
Keywords: AIDS-Related Complex/IMMUNOLOGY/*MICROBIOLOGY/PATHOLOGY Biopsy Cytopathogenic Effect, Viral Human HIV/PHYSIOLOGY HIV Antigens/ANALYSIS Immunohistochemistry Nucleic Acid Hybridization Support, Non-U.S. Gov't Virus Replication JOURNAL ARTICLE

KWDaids-relatedcomplex/immunology/KWDmicrobiology/pathologybiopsycytopathogeniceffect,viralhumanhiv/physiologyhivantigens/analysisimmunohistochemistrynucleicacidhybridizationsupport,non-uKWDsKWDgov'tvirusreplicationjournalarticle
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M8920476

Copyright © 1989 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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