Isolation of HIV in a seronegative demented patient without symptoms of immune deficiency. NLM AIDSLINE Important note: Information in this article was accurate in 1989. The state of the art may have changed since the publication date.

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Isolation of HIV in a seronegative demented patient without symptoms of immune deficiency.

Cancer Detect Prev. 1988;12(1-6):257-65. Unique Identifier : AIDSLINE MED/89028470
Boussin F; Dormont D; Spire B; Fleury H; Rey F; Bequet D; Goasguen J; Brunet P; Centre de Recherches du Service de Sante des Armees, Clamart,; France.

Abstract: A 60-year-old male patient, originating from West Africa, developed acute and regressive neurologic symptoms associated with aphasia, apraxia, acalculia, behavioral impairments, and an epileptic phase. Eighteen months after the onset of the disease, the patient was almost normal. All along the clinical course, biological abnormality patterns were minor. We noted only a mild neutropenia in the blood. We also observed a weak lymphocytosis and elevated protein content in the cerebrospinal fluid. Electroencephalogram examination revealed slow waves which disappeared after remission. A weak ventricular dilatation was detected on CT scan. Neither vascular, nor tumoral, nor a classical infectious origin could be identified. While the patient was seronegative to HIV, a HIV-like virus was isolated twice from his peripheral blood lymphocytes during the disease. Eighteen months later, the patient remained seronegative. He developed neither AIDS nor immunodeficiency. The subtype of HIV has been isolated and characterized, and its neurotropism is being investigated.
Keywords: Antibodies, Monoclonal Case Report Electroencephalography Epilepsy/COMPLICATIONS/MICROBIOLOGY Human HIV/*ISOLATION & PURIF *HIV Seropositivity Immunologic Deficiency Syndromes/DIAGNOSIS/*MICROBIOLOGY Male Middle Age Neutropenia/COMPLICATIONS JOURNAL ARTICLE

KWDantibodies,monoclonalcasereportelectroencephalographyepilepsy/complications/microbiologyhumanhiv/KWDisolation&purifKWDhivseropositivityimmunologicdeficiencysyndromes/diagnosis/KWDmicrobiologymalemiddleageneutropenia/complicationsjournalarticle
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M8920472

Copyright © 1989 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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