[S.l.] : H. Schietinger, M. Hicks, c1984 1 videocassette (30 min.) : sd., col. ; 1/2 in Unique Identifier : AIDSLINE AV/8900058A
Schietinger H; Reynolds B
(Producer) This videotape is designed as a teaching tool for health care providers who will be working with people with AIDS in the home. It discusses the psychosocial impact of AIDS on the patient, the range of social responses, the common physical problems caused by AIDS-related infections and malignancies, the hom
[Columbus, Ohio] : Center for Continuing Medical Education, the Ohio State University College of Medicine, [1987] 30 slides : col. with b&w + 1 sound cassette (60 min. : 1 7/8 ips) + 1 guide (OMEN ; 1987, no. 29) Unique Identifier : AIDSLINE AV/8900036A
Program Ottawa : AIDS Education and Awareness Program of the Canadian Public Health Association, 1987-1991 4 v. : ports Unique Identifier : AIDSLINE CAT/8900817
Monthly. Includes references to literature on phage, animal, or plant viruses, as well as molecular, in vitro, immunological, clinical, epidemiological and other aspects of AIDS. Topical arrangement. Author, subject indexes.
New York : Hemisphere Pub. Corp., c1989 xxix, 583 p. : ill (Series in death education, aging, and health care) Unique Identifier : AIDSLINE CAT/8900072
Control of protein synthesis in eukaryotic cells was studied by using two models: the c-myc oncogene and the translational transactivation of the human immunodeficiency virus (HIV) mRNAs. These two models are examples of control of expression of specific genes at the translation level. It was shown that the presence o
AIDS and the Nervous System. Rosenblum ML et al, eds. New York, Raven Press, p. 13-27, 1988.. Unique Identifier : AIDSLINE ICDB/89648461
Levy RM; Janssen RS; Bush TJ; Rosenblum ML; Dept. of Neurosurgery, Northwestern Univ. Medical Sch., 707; Fairbanks Court, Suite 811, Chicago, IL 60611
Three approaches were used to better characterize the epidemiology of CNS complications of AIDS in the United States : (1) evaluation of Centers for Disease Control (CDC) data on specific CNS diseases in terms of geographic region, risk group, T-cell ratio, serological evidence of infec
AIDS and the Nervous System. Rosenblum ML et al, eds. New York, Raven Press, p. 29-63, 1988.. Unique Identifier : AIDSLINE ICDB/89648462
Levy RM; Bredesen DE; Dept. of Neurosurgery, Northwestern Univ. Medical Sch., 707; Fairbanks Court, Suite 811, Chicago, IL 60611
About 10% of all patients (pts) with AIDS first present with a neurological complaint that leads to a diagnosis of AIDS. Nearly 40% of all AIDS pts develop neurological symptoms during their lifetimes, and neuropathological abnormalities are found at autopsy in 75% of AIDS pts. CNS diseases associated with AIDS are di
Skin Cancer. Recognition and Management. Schwartz RA, ed. New York, Springer, p. 80-98, 1988.. Unique Identifier : AIDSLINE ICDB/89649378
Schwartz RA; UMDNJ-New Jersey Medical Sch., Newark, NJ
Kaposi s sarcoma (KS) is reviewed, with emphasis on cutaneous manifestations of the disease. Topics include: incidence and epidemiology of traditional KS; KS in immunosuppressed non-AIDS patients (pts); KS in AIDS; etiology; cell of origin; clinical spectrum (cutaneous manifestations, possible cutaneous markers, and
Skin Cancer. Recognition and Management. Schwartz RA, ed. New York, Springer, p. 194-225, 1988.. Unique Identifier : AIDSLINE ICDB/89649384
Schwartz RA; UMDNJ-New Jersey Medical Sch., Newark, NJ
The skin may display a number of reaction patterns and lesions that are important to recognize, as they may reflect on internal cancer. Some skin processes or diseases linked with internal cancers may be either unassociated when age-matched controls are used or are only associated fortuitously. Syndromes of special in
Hodgkin's Disease and Non-Hodgkin's Lymphomas in Adults and Children. Fuller LM et al, eds. New York, Raven, p. 47-88, 1988.. Unique Identifier : AIDSLINE ICDB/89649505
Ford RJ Jr; Mehta SR; Sharma S; Dept. of Pathology, Univ. of Texas M.D. Anderson Hosp. and Tumor; Inst., Houston, TX 77030
The immunobiology of Hodgkin s disease (HD) and non-Hodgkin s lymphoma (NHL) is reviewed; and the normal human T-cell, B-cell, and monocyte/macrophage systems are described. Topics include morphology and immunopathologic description of HD (nature of the malignant cell, T-cell regul
Hodgkin's Disease and Non-Hodgkin's Lymphomas in Adults and Children. Fuller LM et al, eds. New York, Raven, p. 346-64, 1988.. Unique Identifier : AIDSLINE ICDB/89649519
Velasquez WS; Fuller LM; Jagannath S; Dept. of Hematology, Univ. of Texas M.D. Anderson Hosp. and Tumor; Inst., Houston, TX 77030
Approx 60% of patients (pts) with diffuse large cell lymphoma (DLCL) present with Stage III or Stage IV disease. This group constitutes the largest and most important cohort of pts with intermediate- or high-grade aggressive lymphomas. Stage III or IV DLCL has become a rather frequent diagnosis in pts with acquired im
Hodgkin's Disease and Non-Hodgkin's Lymphomas in Adults and Children. Fuller LM et al, eds. New York, Raven, p. 381-401, 1988.. Unique Identifier : AIDSLINE ICDB/89649521
Riggs SA; Hagemeister FB; Dept. of Hematology, Univ. of Texas M.D. Anderson Hosp. and Tumor; Inst., Houston, TX 77030
The various types of T-cell malignancies are reviewed and distinguished from one another, with an emphasis on clinical features and the treatment of patients with peripheral T-cell lymphoma, including adult T-cell leukemia-lymphoma. Variously described pathologic entities, probably variants of peripheral T-cell lympho
Clark JW; Longo DL; Biological Response Modifiers Program, Div. of Cancer Treatment,; NCI, Frederick Cancer Res. Facility, Frederick, MD
Until recently, alpha interferons (IFNs) have been the primary IFNs used in clinical trials. The most gratifying results with such IFNs have been obtained in hairy cell leukemia, but sufficient levels of activity have been observed against other malignancies to warrant further pursuit of the role of IFNs in anticancer
Wiernik PH; Albert Einstein Cancer Center and Montefiore Medical Center, New; York, NY
Long-term observations of Hodgkin s disease (HD) patients (pts) who had advanced disease and who were treated with the MOPP (nitrogen mustard, vincristine, procarbazine, and prednisone) combination chemotherapy (CT) regimen at the NCI demonstrated that the majority of the pts were cured by such treatment. These findin
Am Fam Physician. 1987 Jun;35(6):153-9. Unique Identifier : AIDSLINE MED/89047066
Frierson RL; Lippmann SB; University of Louisville School of Medicine, Kentucky.
Psychologic issues for physicians treating AIDS include feelings of helplessness, discomfort with alternative lifestyles, fear of contagion and grief. Physician reactions may include unnecessarily heroic medical interventions, avoidance of the patients families, injudicious use of narcotics, unwillingness to involve
Am J Dermatopathol. 1987 Apr;9(2):85-9. Unique Identifier : AIDSLINE MED/89048107
Strutton G; Weedon D; Department of Pathology, Royal Brisbane Hospital, Australia.
Acro-angiodermatitis, usually related to venous insufficiency of the lower limbs, may simulate some of the features of Kaposi s sarcoma, both to the clinician and the dermatopathologist. With the increasing incidence of Kaposi s sarcoma related to the acquired immune deficiency syndrome (AIDS), there is a greater awar
Rivano MT; Falini B; Stein H; Canino S; Ciani C; Gerdes J; Ribacchi R; Gobbi M; Pileri S; Istituto di Anatomia e Istologia Patologica, Universita di; Bologna, Italy.
Eight examples of histiocytic necrotizing lymphadenitis without granulocytic infiltration (Kikuchi s lymphadenitis) are described. They occurred in young or middle-aged women who usually complained of latero-cervical lymphadenopathy. Serology revealed significant titres for Epstein-Barr virus and Yersinia enterocoliti
Brandtzaeg P; Institute of Pathology, University of Oslo, Rikshospitalet, Oslo,; Norway.
Monoclonal antibodies (MoAbs) to monocytes/macrophages usually detect surface membrane antigens that are reactive only on cryostat sections of unfixed tissue. Such sections do not afford structural preservation conducive to satisfactory morphological characterization of various cell types. Moreover, in pathology labor
Sekiguchi S; Ito K; Kobayashi M; Ototake N; Kosuda M; Kwon KW; Ikeda H; Research Division, Hokkaido Red Cross Blood Center, Sapporo,; Japan.
One of our major aims was to find ways to utilize outdated or virus-contaminated blood. Pyridoxylated hemoglobin (PLP-Hb), a possible substitute for red cells as an artificial oxygen carrier was prepared from outdated human blood. By conjugation with polyethylene glycol (PEG), the biological half life was increased ab
Crit Care Clin. 1988 Oct;4(4):831-44. Unique Identifier : AIDSLINE MED/89027797
Wilkinson JD; Greenwald BM; Cornell University, New York.
Increasing numbers of infants and children with AIDS are being admitted to the PICU, especially in certain geographic areas. Clear diagnostic criteria are available to aid in the diagnosis. As many as 50 per cent of these patients may be first diagnosed with AIDS during their PICU stay. Most patients are admitted beca
Cancer Detect Prev. 1988;12(1-6):205-10. Unique Identifier : AIDSLINE MED/89028461
Hamilton MS; Becker J; Hamilton BL; Department of Biological Structure, University of Washington,; Seattle.
It has been postulated that an acquired immunodeficiency syndrome develops in neonates as the result of a maternally induced graft-vs-host disease (GVHD) that develops when sufficient numbers of maternal lymphocytes are transferred to the fetus across the placental barrier. The present study was done to determine whet
Cancer Detect Prev. 1988;12(1-6):211-6. Unique Identifier : AIDSLINE MED/89028462
Kekow J; Hobusch G; Gross WL; Department of Internal Medicine, Christian Albrecht University,; Kiel, Federal Republic of Germany.
In addition to the well-known T-cell dysfunctions in AIDS, hypergammaglobulinemia, mostly IgG, and autoimmune phenomena indicate that B cells are also involved. Reports of HIV-infected and activated B cells suggest T cell-independent B-cell abnormalities. In order to assess the IgG subclasses involved in hypergammaglo
Cancer Detect Prev. 1988;12(1-6):217-24. Unique Identifier : AIDSLINE MED/89028463
Biberfeld P; Porwit A; Biberfeld G; Harper M; Bodner A; Gallo R; Department of Pathology, Karolinska Institute, Stockholm, Sweden.
Studies of human immunodeficiency virus (HIV) associated lymphadenopathy by histopathology and immunopathology showed conspicuous changes of follicular B-cell areas from a marked hyperplasia to complete involution. Immunohistochemistry showed a corresponding increase in follicular dendritic reticulum cells (FDRC) foll
Cancer Detect Prev. 1988;12(1-6):237-41. Unique Identifier : AIDSLINE MED/89028467
Monfardini S; Tirelli U; Vaccher E; Ambrosini A; Andriani A; Silvestroni IB; Broccia G; Chisesi T; Fassio F; Deliliers GL; et al; Gruppo Italiano Cooperativo AIDS & Tumori (GICAT), Aviano, Italy.
For the first time the presence of a consistent number of malignant lymphomas among persons at high risk for AIDS has been documented in Italy . The majority of our cases started to occur in 1983, in line with the trend for a 2-year delay in the spread of the epidemic of AIDS in Euro
Cancer Detect Prev. 1988;12(1-6):243-8. Unique Identifier : AIDSLINE MED/89028468
Keyserlingk H; Ludwig WD; Seibt H; Ruhl H; Hoffken G; Department of Hematology and Oncology, University Medical Center; Steglitz, Free University of Berlin, West Berlin, Federal; Republic of Germany.
Hodgkin s disease (HD) has been reported in association with the acquired immunodeficiency syndrome (AIDS) only occasionally, and these patients seemed to have aggressive unusual HD. We report an additional case of HD in a 50-year-old homosexual man with a marked change of his clinical course after the development of
Cancer Detect Prev. 1988;12(1-6):249-55. Unique Identifier : AIDSLINE MED/89028469
Chavanet PY; Giroud M; Lancon JP; Borsotti JP; Waldner-Combernoux AC; Pillon D; Maringe E; Caillot D; Portier H; Department of Infectious and Tropical Diseases, University; Hospital of Dijon, France.
An electrophysiological study on peripheral nerves conduction was performed on HIV-seropositive patients without neurological signs on clinical examination. Eight of the 28 patients (28%) had an infraclinical neuropathy, which was myelinic or axonal and rather distal than proximal. The mechanism of these involvements
Cancer Detect Prev. 1988;12(1-6):257-65. Unique Identifier : AIDSLINE MED/89028470
Boussin F; Dormont D; Spire B; Fleury H; Rey F; Bequet D; Goasguen J; Brunet P; Centre de Recherches du Service de Sante des Armees, Clamart,; France.
A 60-year-old male patient, originating from West Africa, developed acute and regressive neurologic symptoms associated with aphasia, apraxia, acalculia, behavioral impairments, and an epileptic phase. Eighteen months after the onset of the disease, the patient was almost normal. All along the clinical course, biologi
Cancer Detect Prev. 1988;12(1-6):267-72. Unique Identifier : AIDSLINE MED/89028471
Tirelli U; Vaccher E; Zagonel V; Rezza G; Palmieri G; Pizzoccaro G; Parrinello AE; Carbone A; Monfardini S; Gruppo Italiano Cooperativo AIDS & Tumori (GICAT), Aviano, Italy.
Since 1981 there has been a constant rise in the incidence of squamous cell carcinoma of the oral cavity and the anorectum among homosexual men in the United States . In addition, lung cancer, testicular cancer, chronic lymphocytic leukemia, malignant melanoma, basal cell carcinoma, cer
Cancer Detect Prev. 1988;12(1-6):273-6. Unique Identifier : AIDSLINE MED/89028472
Rogna S; Puppo F; Stagnaro R; Panunzio V; Torresin A; Pierri I; Indiveri F; Cattedra di Patologia Medica RR, ISMI, University of Genova,; Italy.
AIDS patients often develop a conspicuous although functionally ineffective hypergammaglobulinaemia. We have treated four patients affected by AIDS or AIDS-related complex (ARC) with repeated courses of plasmaexchange coupled with immunoglobulin infusions. The schedule of each course was as follows: one plasmapheresis
Cancer Detect Prev. 1988;12(1-6):31-7. Unique Identifier : AIDSLINE MED/89028478
Olsen RG; Lewis MG; Bauer RM; Tarr MJ; Mathes LE; Lafrado LJ; Blakeslee JR Jr; Department of Veterinary Pathobiology, College of Veterinary; Medicine, Ohio State University, Columbus 43210.
The Human T-lymphotropic virus type I (HTLV-I) infected cell line MT-2 was studied to obtain HTLV-I or related proteins for the purpose of producing an effective vaccine for HTLV-I infection. The cells were characterized as to HTLV-I antigen expression during the cell cycle and antigens released into the culture fluid
EMBO J. 1988 Oct;7(10):3143-7. Unique Identifier : AIDSLINE MED/89030610
Garcia JA; Harrich D; Pearson L; Mitsuyasu R; Gaynor RB; Department of Medicine, UCLA School of Medicine 90024.
The transcriptional regulation of the human immunodeficiency virus (HIV) type I involves the interaction of both viral and cellular proteins. The viral protein tat is important in increasing the amount of viral steady-state mRNA and may also play a role in regulating the translational efficiency of viral mRNA. To iden
EMBO J. 1988 Sep;7(9):2831-7. Unique Identifier : AIDSLINE MED/89030649
Parkin NT; Cohen EA; Darveau A; Rosen C; Haseltine W; Sonenberg N; Department of Biochemistry, McGill University, Montreal, Quebec,; Canada.
The first 111 nt from the 5 end of human immunodeficiency virus type 1 (HIV-1) mRNAs are shown to have a strong inhibitory effect on the translation of mRNA in in vitro translation extracts as well as in Xenopus oocytes. Mutations in the sequence of the 5 untranslated region (UTR) designed to disrupt predicted secon
Eur Heart J. 1988 Aug;9(8):887-92. Unique Identifier : AIDSLINE MED/89030766
Corallo S; Mutinelli MR; Moroni M; Lazzarin A; Celano V; Repossini A; Baroldi G; Division of Cardiology, University Hospital L. Sacco, Milan,; Italy.
Few data are available about cardiac involvement in AIDS. We examined 102 consecutive patients with AIDS diagnosed clinically and serologically (Walter Reed Stage 5 and 6), by means of TM and cross-sectional echocardiography with the aim of detecting cardiac abnormalities. None of the patients had overt clinical signs
Mandelli C; Cesana M; Ferroni P; Lorini GP; Aimo GP; Tagger A; Bianchi PA; Conte D; Patologia Medica III, Istituto di Scienze Mediche, Milano, Italy.
Of 242 north Italian heroin addicts, 24 (9.9%) were HBsAg positive. HBeAg was positive in two of them (8.3%), anti-HBe in 16 (66.6%) and anti-HDV in 21 (87.5%). Of the 218 HBsAg negative, 182 (83.5%) had anti-HBc, 72 (33.0%) anti-HBe and 97 (44.5%) anti-HBs. One-hundred-eighty-five drug addicts were anti-HIV positive
Salmaso S; Amendola G; Martorelli S; Gnesivo C; Laboratorio di Epidemiologia e Biostatistica, Istituto Superiore; di Sanita, Rome, Italy.
A survey was carried out on all cases of pulmonary and extrapulmonary tuberculosis reported in the Latium region of Italy during 1986, in order to characterize them from bacteriological and epidemiological points of view. A total of 497 TB notifications were investigated; reliable m
Kornstein MJ; Parker GA; Mills AS; Department of Pathology, Medical College of Virginia, Virginia; Commonwealth University, Richmond 23298-0662.
We report a case of a benign lymphoepithelial lesion of the parotid gland in a patient with progressive generalized lymphadenopathy (PGL) related to human immunodeficiency virus. Serologic studies and immunoperoxidase studies for lymphocyte subsets, which have not previously been reported in this lesion, suggest invol
Int J Cancer. 1988 Nov 15;42(5):687-9. Unique Identifier : AIDSLINE MED/89032680
Delaporte E; Dupont A; Peeters M; Josse R; Merlin M; Schrijvers D; Hamono B; Bedjabaga L; Cheringou H; Boyer F; et al; International Centre for Medical Research of Franceville, Gabon.
In 1986 a survey to determine the distribution of HTLV-I infection was conducted in Gabon in a representative sample of adults and children. Five samples were taken in adults and 2 samples in children living in urban and rural areas. Samples were taken by the cluster sampling techni
Rappersberger K; Gartner S; Schenk P; Stingl G; Groh V; Tschachler E; Mann DL; Wolff K; Konrad K; Popovic M; Department of Dermatology I, University of Vienna Medical School,; Austria.
Human epidermal Langerhans cells (LC) are HLA-DR+/DQ+, CD1+, CD4+ dendritic antigen-presenting leukocytes. Based on the observation that in certain human immunodeficiency virus type 1 (HIV-1) infected individuals, LC are the only epidermal cells to react with monoclonal antibodies against HIV-1 isolate termed human T
Cooper JS; Division of Radiation Oncology, NYU Medical Center, N.Y. 10016.
Between 1972 and 1985, 82 Classic Kaposi s Sarcomas were treated by radiotherapy in the Division of Radiation Oncology at NYU Medical Center. Doses ranged from 650 cGy in 1 fraction to 3,500 cGy in 10 fractions, reflecting the judgement of the responsible physician. A correlation was observed between the treatment giv
Spiramycin, 3 g daily, was used to treat immunocompromised patients with chronic diarrhoea due to Cryptosporidium. Most patients treated had acquired immune deficiency syndrome. Among 37 patients evaluated, 28 had a favourable response, defined as a reduction in the daily number of bowel movements to less than 50% of
Akeson AL; Wiginton DA; Dusing MR; States JC; Hutton JJ; Children's Hospital Research Foundation, Cincinnati, Ohio.
Adenosine deaminase (ADA) deficiency in humans is one cause of severe combined immunodeficiency disease. Single base mutations affecting the ADA protein have been identified for both alleles of the ADA-deficient cell line GM2606 and for one allele of the ADA-deficient cell line GM2825A. One allele of GM2606 has a muta
Buchbinder A; Josephs SF; Ablashi D; Salahuddin SZ; Klotman ME; Manak M; Krueger GR; Wong-Staal F; Gallo RC; Laboratory of Tumor Cell Biology, National Cancer Institute,; Bethesda, Maryland 20892.
Polymerase chain reaction amplification (PCR) is a recently described technique that allows for the amplification of a given sequence of DNA. It can be used to reliably amplify sequences of up to 3 kb within hours. The amplified sequence can then be recognized by hybridization with a specific probe after transfer onto
Jackson S; Tarkowski A; Collins JE; Dawson LM; Schrohenloher RE; Kotler DP; Koopman WJ; Department of Microbiology, University of Alabama, Birmingham; 35294.
The sera of 34 acquired immune deficiency syndrome (AIDS) patients and 20 healthy male homosexuals were examined for the presence of elevated levels of IgA and IgM rheumatoid factor (RF) and compared with results obtained with sera from 23 healthy laboratory volunteers. IgA RF levels were elevated (greater than 3 stan
Dechamps C; Peigue-Lafeuille HH; Laveran H; Beytout J; Roger H; Beytout D; Service de Bacteriologie-Virologie, Faculte de Medicine,; Clermont-Ferrand, France.
Echovirus types 4 and 33 and coxsackievirus type B1 were recovered from vesicular lesions in four adults. Patient 1 had cutaneous localized vesicles, patient 2 had a recurrent cutaneous vesicle, and patients 3 and 4 had mucosal vesicles. Three of the patients were suspected of having herpesvirus lesions. One of the pa
Dryden MS; Shanson DC; St Stephen's Hospital, London, U.K.
Diarrhoea is common in patients infected with the human immunodeficiency virus (HIV). We sought the cause of diarrhoea in all HIV antibody-positive patients with diarrhoea who presented at St Stephen s Hospital, London over a period of 15 months. Altogether, 441 specimens from 179 patients were examined. Infective cau
Janoff EN; Douglas JM Jr; Gabriel M; Blaser MJ; Davidson AJ; Cohn DL; Judson FN; Infectious Disease Section, Veterans Administration Medical; Center, Minneapolis, Minnesota 55417.
We characterized the effect of infection with human immunodeficiency virus type 1 (HIV) on levels of total immunoglobulins and pneumococcal vaccine-specific immunoglobulins in 28 heterosexual and 25 homosexual men seronegative for HIV; 27 asymptomatic, seropositive homosexual men; and 21 patients with AIDS. Total seru
Lange WR; Moore JD; Cibull ML; Brutsche RL; Addiction Research Center, National Institute on Drug Abuse,; Baltimore, MD 21224.
Fulminant hepatitis B virus (HBV) infection is often attributable to co-infection with the delta agent. However, delta produces a variable pattern of illness in HBsAg-positive addicts. It is often not detectable in fulminant cases of hepatitis B, and other cofactors have been conjectured regarding the pathogenesis of
Geelen JL; Minnaar RP; Boom R; van der Noordaa J; Goudsmit J; Department of Virology, University of Amsterdam, The Netherlands.
Rat cell lines were established in which the bacterial chloramphenicol acetyltransferase (CAT) gene under control of the human immunodeficiency virus (HIV) long terminal repeat (LTR) was stably integrated. The cell lines showed a repressed phenotype for CAT expression, but could be induced for it by inhibition of prot
J Med Virol. 1988 Sep;26(1):99-109. Unique Identifier : AIDSLINE MED/89036187
Barrett JC; Division of Medical Statistics and Epidemiology, London School of; Hygiene and Tropical Medicine, England.
The spread of human immunodeficiency virus (HIV) by heterosexual intercourse, during the first 2 years following the introduction of the virus among a sexually active and unprotected group of men and women, is modelled by Monte Carlo simulation. A beta distribution of the infectee s risks of infection per infected par
J Med Virol. 1988 Oct;26(2):145-52. Unique Identifier : AIDSLINE MED/89036192
Hirschman SZ; Zucker ML; Department of Medicine, Mount Sinai School of Medicine, City; University of New York, New York 10029.
Sixty-eight of 73 patients with human immunodeficiency virus (HIV) infection were positive when tested for the presence of hepatitis B virus (HBV)-related DNA sequences in peripheral blood mononuclear cells (PBMCs) by the dot blot method. Twenty-two of the positive DNAs were examined by Southern hybridization and all
J Med Ethics. 1988 Sep;14(3):154-60. Unique Identifier : AIDSLINE MED/89037099
Murphy TF; Center for Educational Development, University of Illinois,; Chicago.
There are religious and philosophical versions of the thesis that AIDS is a punishment for homosexual behaviour. It is argued here that the religious version is seriously incomplete. Because of this incompleteness and because of the indeterminacies that ordinarily attend religious argumentation, it is concluded that t
Shida H; Hinuma Y; Hatanaka M; Morita M; Kidokoro M; Suzuki K; Maruyama T; Takahashi-Nishimaki F; Sugimoto M; Kitamura R; et al; Institute for Virus Research, Kyoto University, Japan.
We constructed recombinant vaccinia viruses (RVVs) that expressed human T-cell leukemia virus type I (HTLV-I) envelope glycoproteins by using attenuated vaccinia viruses (VVs) which have much lower neurovirulence than the WR strain that is extensively used as a vector. The RVV produced from the LC16mO strain, one of t
JAMA. 1988 Nov 18;260(19):2879-82. Unique Identifier : AIDSLINE MED/89037510
Pahwa S; Biron K; Lim W; Swenson P; Kaplan MH; Sadick N; Pahwa R; Department of Pediatrics, North Shore University Hospital,; Manhasset, NY 11030.
Acyclovir has become the treatment of choice for varicella-zoster virus (VZV) infections in immunocompromised individuals. This article describes a 4-year-old girl congenitally infected with human immunodeficiency virus who developed a continuous cutaneous infection with VZV tha
Ortiz C; Meneses R; Jaffe D; Fernandez JA; Perez G; Bourgoignie JJ; Department of Medicine, University of Miami School of Medicine,; Florida.
Fifty-one adults with HIV infection, including 20 chronic hemodialysis patients with superimposed HIV infection and 31 patients with HIV-associated nephropathy requiring chronic maintenance hemodialysis were followed to evaluate survival on outpatient dialysis in relation to the clinical stage of the HIV infection. Re
Black JL; Jones LH; Dept. of Pediatrics, University of California, San Diego; 92103-9981.
Acquired Immunodeficiency Syndrome (AIDS) challenges schools as the frontline defense against this epidemic. School personnel should become knowledgeable about human immunodeficiency virus (HIV) infection and get involved in presenting quality HIV/AIDS education programs. This paper provides an epidemiological update
Several documents have been published offering guidelines for implementing AIDS education. These documents generally cite the need for AIDS education, and identify issues and concerns inherent in planning AIDS education. Though such guidelines are beneficial in establishing the legitimate need for AIDS education, the
Sanford JC; Department of Horticultural Sciences, Cornell University, Geneva,; NY 14456.
The principle of pathogen-derived resistance (the PDR principle) has been put forward as a broadly-applicable conceptual tool for use in designing genes which will confer resistance to pathogens. This paper reveals an example of how the PDR principle may be applied in the field of human medicine. Specifically it is sh
Between 1983 and 1987, 19 patients presenting with encephalic involvement of AIDS had an EEG recording during the early neurological examination. In 8 patients, EEGs were repeated 1 to 11 times during the course of the disease. All recordings were abnormal. A good EEG correlation existed with clinical, virological and
Neurosci Lett. 1988 Sep 23;92(1):34-9. Unique Identifier : AIDSLINE MED/89040677
Hirayama M; Miyadai T; Yokochi T; Sato K; Kubota T; Iida M; Fujiki N; Second Department of Internal Medicine, Fukui Medical School,; Japan.
To clarify the pathogenesis of human T-lymphotropic virus type I (HTLV-I)-associated myelopathy (HAM), we examined whether HTLV-I infects normal human glial cells in vitro with induction of the major histocompatibility complex (HMC) class II antigen by immunofluorescence method. It was found that about 10% of astrocyt
Burns ER; Krieger BZ; Bernstein L; Rubinstein A; Department of Laboratory Medicine, Albert Einstein College of; Medicine, Bronx, New York 10461.
The mechanism underlying the prolonged activated partial thromboplastin time (APTT) seen in some pediatric patients with acquired immunodeficiency syndrome (AIDS) and opportunistic infections was studied. A circulating inhibitor of coagulation was demonstrated in three patients. The inhibitor appears to be an immunogl
Ellaurie M; Burns ER; Bernstein LJ; Shah K; Rubinstein A; Department of Pediatrics, Albert Einstein College of Medicine,; Bronx, New York 10461.
Thrombocytopenia occurs in 13% of children with symptomatic human immunodeficiency virus (HIV) infection. The clinical and laboratory course of 19 children infected with HIV with thrombocytopenia is described. Bone marrow aspirates showed normal to increased numbers of megakaryocytes. Levels of antiplatelet antibodies
Pathol Res Pract. 1988 Aug;183(4):425-33. Unique Identifier : AIDSLINE MED/89041732
Falk S; Muller H; Stutte HJ; Senckenbergisches Zentrum der Pathologie, Klinikum der J.W.; Goethe-Universitat Frankfurt, West Germany.
72 spleens from AIDS patients were studied by histologic and immunohistochemical methods. Apart from the opportunistic infections and malignancies typically occurring in AIDS patients (malignant lymphomas, Kaposi s sarcoma, mycobacterial infections, cryptococcosis, cytomegalovirus
Proc Natl Acad Sci U S A. 1988 Nov;85(21):8286-90. Unique Identifier : AIDSLINE MED/89042170
Seto E; Yen TS; Peterlin BM; Ou JH; Department of Pathology, Howard Hughes Medical Institute, School; of Medicine, University of California, San Francisco 94143-0506.
Human immunodeficiency virus 1 has been implicated as the main etiologic agent of the acquired immunodeficiency syndrome. However, other infectious agents may accelerate the progression of this disease. In particular, hepatitis B virus has been suggested as one such cofactor. Therefore, we have investigated the effect
Flandre P; Valleron AJ; URBB, INSERM U 263, Universite de Paris.
This paper presents an evaluation of the demographic impact of mortality by AIDS in the next future years, in France . Future cases are predicted by using a regression technique based on an exponential model. Three demographic indicators are computed: Years of Potential Life Lost (Y
Pollak M; Rozenbaum W; Viallefont A; Gharakhanian S; Aime F; CNRS-EHESS, Paris, France.
A questionnaire survey of 103 patients of the Paris Pitie-Salpetriere Hospital measures the changes in family life, work relations and in sexual behaviour occurring after an HIV infection diagnosis. Most patients choose to keep their diagnosis secret, an attitude that places them into a double bind situation. This sil
Schweiz Med Wochenschr. 1988 Nov 12;118(45):1641-4. Unique Identifier : AIDSLINE MED/89043877
Perrin LH; Zubler R; Hirschel B; Martin JL; Salomon D; Saurat JH; Fryc O; Departement de medecine interne, Hopital cantonal; universitaire, Geneve.
The medical history and laboratory data of two persons who have been in contact with HIV-I positive carrier individuals are reported. The serologic data of successive serum samples collected from these persons were first negative, then positive (including antibodies directed against Gag and Env gene products), and fin
Scott Med J. 1988 Aug;33(4):294-5. Unique Identifier : AIDSLINE MED/89043909
Joshi UY; Cameron SO; Sommerville JM; Sommerville RG; Department of Genito-Urinary Medicine, Glasgow Royal Infirmary.
Between 1 March 1985 and 28 February 1987, 1659 patients attending Glasgow Genito-Urinary Medicine (GUM) Clinics were tested for antibodies to human immunodeficiency virus (HIV). Forty (2.4%) were positive. Thirty-seven of these were homosexual (36/37) or bisexual (1/37) males. The overall prevalence of antibodies to
Science. 1988 Nov 11;242(4880):916-9. Unique Identifier : AIDSLINE MED/89043968
Stoneburner RL; Des Jarlais DC; Benezra D; Gorelkin L; Sotheran JL; Friedman SR; Schultz S; Marmor M; Mildvan D; Maslansky R; AIDS Research Unit, New York City Department of Health, NY 10013.
Increasing mortality in intravenous (IV) drug users not reported to surveillance as acquired immunodeficiency syndrome (AIDS) has occurred in New York City coincident with the AIDS epidemic. From 1981 to 1986, narcotics-related deaths increased on average 32% per year from 492 in 1981 to 1996 in 1986. This increase in
South Med J. 1988 Nov;81(11):1439-41. Unique Identifier : AIDSLINE MED/89044145
Baber WW; Carter CF; Department of Radiology, Louisiana State University Medical; Center, New Orleans.
We have reported the case of a child with AIDS manifested by an acute episode of stridor associated with candidal esophagitis. Stridor is uncommon in candidal esophagitis, and we believe this is the first report of it as a presenting symptom in childhood AIDS.
Weinberg JJ; Cohen P; Malhotra R; Department of Medicine, Kings County Hospital, SUNY Health; Science Center at Brooklyn.
Extrapulmonary tuberculosis has been noted to occur frequently in patients with the Acquired Immunodeficiency Syndrome (AIDS). Tuberculous liver abscesses are rare. The following case report describes a patient with Human Immunodeficiency Virus (HIV) antibody who exemplifies this unusual manifestation of mycobacterial
Mizusawa H; Hirano A; Llena JF; Shintaku M; Department of Pathology, Montefiore Medical Center, Bronx, NY; 10467.
Cerebrovascular lesions were seen in 28 of 83 cases (34%) of acquired immune deficiency syndrome (AIDS). Cerebral hemorrhage was noted in 4 cases, cerebral infarct in 23 cases and both in 1 case. Cerebral hemorrhage was in various locations such as intraparenchymal, subarachnoid space, subdural space and epidural spac
Am J Gastroenterol. 1988 Nov;83(11):1304-5. Unique Identifier : AIDSLINE MED/89047332
Hofstetter SR; Stollman N; Department of Surgery, New York University School of Medicine,; New York.
Visceral Kaposi s sarcoma is a common manifestation of the acquired immune deficiency syndrome (AIDS). Most lesions are clinically silent, detected only by radiographic or endoscopic studies. We report the first instance of AIDS-related jejunal Kaposi s sarcoma presenting with small intestinal obstruction due to intus
Am J Epidemiol. 1988 Nov;128(5):1153-61. Unique Identifier : AIDSLINE MED/89047357
Tsugane S; Watanabe S; Sugimura H; Otsu T; Tobinai K; Shimoyama M; Nanri S; Ishii H; Epidemiology Division, National Cancer Center Research Institute,; Tokyo, Japan.
Serologic tests for human T lymphotropic virus type I (HTLV-I) and hepatitis B virus infections were conducted in 1986 in two Japanese immigrant colonies located in Santa Cruz, Bolivia . A total of 322 adults (283 Japanese and 39 Bolivians) over age 35 years and 305 children (166 J
Am J Public Health. 1988 Dec;78(12):1535-8. Unique Identifier : AIDSLINE MED/89047960
Schechter MT; Craib KJ; Willoughby B; Douglas B; McLeod WA; Maynard M; Constance P; O'Shaughnessy M; Vancouver Lymphadenopathy-AIDS Study Group, St. Paul's Hospital,; British Columbia, Canada.
To measure the magnitude of risk reduction within a cohort of homosexual men, questionnaire responses in April 1984-March 1985 were compared to those in October 1986-September 1987. A total of 361 subjects were eligible (231 seronegative, 130 seropositive). The annual number of sex partners declined significantly from
Am J Public Health. 1988 Dec;78(12):1539-45. Unique Identifier : AIDSLINE MED/89047961
Selik RM; Castro KG; Pappaioanou M; AIDS Program, Centers for Disease Control, Atlanta, GA 30333.
We analyzed the variation in the risk of AIDS in US Blacks, Hispanics, and other racial/ethnic groups relative to that in Whites (non-Hispanic) by geographic area and mode of acquiring HIV infection, based on data reported between June 1, 1981 and January 18, 1988 to the Centers for Disease Control and 1980 US census
Am J Public Health. 1988 Dec;78(12):1575-7. Unique Identifier : AIDSLINE MED/89047968
van Griensven GJ; de Vroome EM; Tielman RA; Goudsmit J; van der Noordaa J; de Wolf F; Coutinho RA; Department of Public Health and Environment, Municipal Health; Service of Amsterdam, The Netherlands.
Between October 1984 and May 1986, 746 homosexual men, living in and around Amsterdam, The Netherlands , were surveyed at three consecutive six months periods regarding their sexual behavior. At the start of the study all subjects, of whom 234 (31 per cent) were HIV-Ab seroposi
Am J Trop Med Hyg. 1988 Oct;39(4):398-405. Unique Identifier : AIDSLINE MED/89048058
Reeves WC; Cuevas M; Arosemena JR; De Lao SL; Gomez B; Ulloa E; Quiroz E; Canton-Dutary A; Reyes R; Saenz R; et al; Gorgas Memorial Laboratory, Santo Tomas Hospital, Republic of; Panama.
Thirty-one documented acquired immune deficiency syndrome (AIDS) cases occurred in Panama during 1984-1987. Twenty-three (74%) patients were homosexual males and all but 2 patients recognized prior to June 1987 have died. To identify risk factors for human immunodeficiency virus infection, 287 male homosexual resident
Ann Intern Med. 1988 Nov 1;109(9):718-21. Unique Identifier : AIDSLINE MED/89048703
STUDY OBJECTIVE: To determine the effect of zidovudine on platelet counts in patients with human immunodeficiency virus (HIV)-associated thrombocytopenia. DESIGN: The study was prospective, controlled, and blinded. Each patient received active drug and placebo. Platelet counts were compared before and after receiving
Sommadossi JP; Carlisle R; Schinazi RF; Zhou Z; Department of Pharmacology, University of Alabama, Birmingham; 35294.
We evaluated the effects of natural purine and pyrimidine nucleosides on protection from or reversal of 3 -azido-3 -deoxythymidine ( AZT ) cytotoxicity in human bone marrow progenitor cells by using clonogenic assays. The selectivity of the protection o
Dannemann BR; Israelski DM; Remington JS; Department of Immunology and Infectious Diseases, Research; Institute, Palo Alto, CA 94301.
At present, therapy for toxoplasmic encephalitis (TE) is the combination of pyrimethamine with sulfadiazine or trisulfapyrimidines. Unfortunately, due to adverse reactions to sulfonamides, many patients with acquired immunodeficiency syndrome (AIDS) are unable to receive a complete course of therapy. The promising res
Kessler HA; Benson CA; Urbanski P; Department of Medicine, Rush-Presbyterian-St Luke's Medical; Center, Chicago, IL 60612.
We describe two patients with human immunodeficiency virus infection and oral hairy leukoplakia whose tongue lesions resolved on oral zidovudine therapy. During therapy, each patient had a measurable reduction in human immunodeficiency virus antigen corresponding with clinical regression of oral lesions. The clinical
Wilkes MS; Jacobs TA; Milberg J; Stoneburner R; Office of AIDS Research, New York City Department of Health.
The autopsy rate was examined for patients dying of acquired immunodeficiency syndrome (AIDS) in New York City from 1982 through 1986 to determine if individuals dying of AIDS had autopsy rates that differed from the general population. Using data from death certificates, verified by hospital records, autopsy rates fo
Ioachim HL; Ryan JR; Blaugrund SM; Department of Pathology, Lenox Hill Hospital, New York, NY 10021.
Normally, lymph nodes are intimately associated with the salivary glands, particularly the parotid gland. Several lymph nodes are embedded in the parotid gland, other lymph nodes are adjacent to the submaxillary gland, and ectopic salivary gland acini and ducts are commonly present in cervical lymph nodes. These saliv
Tschirhart D; Klatt EC; Department of Pathology, Los Angeles County-University of; Southern California Medical Center.
Fourteen cases of toxoplasmosis in subjects at autopsy with acquired immunodeficiency syndrome are reviewed. Death was related to toxoplasmosis in four cases: in three from central nervous system complications and in one case from myocarditis. In six cases the infection was identified outside of the central nervous sy
Giangaspero F; Foschini MP; Institute of Anatomic Pathology, University of Bologna, Italy.
We report a case of a 25-year-old woman affected by the acquired immunodeficiency syndrome in whom the neuropathologic examination disclosed the presence of diffuse axonal swellings in the brain stem and in selected areas of cerebral hemispheres. These lesions, although microscopically similar to those previously desc
Piehl MR; Kaplan RL; Haber MH; Department of Pathology, Rush-Presbyterian-St Luke's Medical; Center, Chicago, IL 60612-3864.
We describe a case of disseminated penicilliosis in a patient with the acquired immunodeficiency syndrome. Penicillium marneffei was cultured from the blood, bone marrow, sputum, stool, and skin; the yeast forms were demonstrated in skin and bone marrow biopsy specimens. To our knowledge, this is the first reported ca
Biochem Pharmacol. 1988 Oct 15;37(20):3947-52. Unique Identifier : AIDSLINE MED/89050265
Schroder HC; Sarin PS; Rottmann M; Wenger R; Maidhof A; Renneisen K; Muller WE; Institut fur Physiologische Chemie, Johannes; Gutenberg-Universitat, Mainz, Federal Republic of Germany.
Human immunodeficiency virus type 1 (HIV-1) gene expression is modulated by some virus-encoded proteins, possibly acting at multiple levels of control, which are also known to be involved in the regulation of gene expression in uninfected cells (transcriptional, post-transcriptional, nucleocytoplasmic transport, and t
Cancer Detect Prev. 1988;12(1-6):231-6. Unique Identifier : AIDSLINE MED/89028466
Kekow J; Kern P; Rautmann A; Gross WL; Department of Internal Medicine, Christian Albrecht University,; Kiel, Federal Republic of Germany.
In AIDS elevated serum Ig levels and autoimmune phenomena indicate that B cells are also involved. The human immunodeficiency virus (HIV) can be cultivated in B cells, and HIV can stimulate B cells. In order to characterize the B-cell dysfunction and conditions for modulating it, functional studies with highly purifie
Cancer Detect Prev. 1988;12(1-6):277-82. Unique Identifier : AIDSLINE MED/89028473
Fuchs DN; Hausen A; Hengster P; Reibnegger GJ; Unterweger B; Werner ER; Hinterhuber H; Dierich MP; Wachter H; Institute for Medical Chemistry and Biochemistry, University of; Innsbruck, Austria.
In a longitudinal study, we examined 183 parenteral drug addicts who were imprisoned in Innsbruck, Austria , from March 1985 to March 1987. Thirty-seven percent of the patients had anti-HIV-antibodies. A 2-year follow-up of 43 seropositive patients revealed some evidence that urina
Carme B; M'Pele P; Mbitsi A; Kissila AM; Aya GM; Mouanga-Yidika G; Mboussa J; Itoua-Ngaporo A; Hopital universitaire de Brazzaville, RP du Congo.
To determine the frequency of opportunistic parasitic and mycotic diseases in adult AIDS patients in the Congo, a study was conducted at l Hopital Universitaire de Brazzaville in 1986 and 1987. Diagnosis of AIDS was made using the WHO clinical definition for Africa (Bangui, 1985) and HIV seropositivity Pasteur Elisa t
Ascher MS; Sheppard HW; Viral and Rickettsial Disease Laboratory, California Department; of Health Services, Berkeley 94704.
Epidemiological evidence has implicated the human immunodeficiency virus (HIV) as the etiological agent of the acquired immunodeficiency syndrome (AIDS) (Barre-Sinoussi et al., 1983; Sarngadharan et al., 1984; Kitchen et al., 1984; Levy et al., 1984). Primary infection with HIV is accompanied by an acute flu-like illn
Kagawa FT; Kirsch CM; Yenokida GG; Levine ML; Division of Pulmonary Medicine, Santa Clara Valley Medical; Center, San Jose, CA 95128.
We investigated whether serum lactate dehydrogenase activity (LD) is significantly elevated in patients with acquired immunodeficiency syndrome (AIDS) and Pneumocystis carinii pneumonia (PCP) when compared to patients with non-Pneumocystis pneumonia. We measured LD (U/L), blood total lymphocyte count (1,000/cu mm), an
O'Donnell CR; Bader MB; Zibrak JD; Jensen WA; Rose RM; Department of Medicine, New England Deaconess Hospital, Boston; 02159.
Pulmonary function test results of individuals with the acquired immunodeficiency syndrome (AIDS) were analyzed to determine the prevalence of abnormally low forced expiratory flow rates and bronchial hyperreactivity. Of 99 individuals with AIDS, a total of 44 (44 percent) had either low forced expiratory flow rates o
Charron M; Ackerman ES; Kolodny GM; Rosenthall L; Beth Israel Hospital, Department of Nuclear Medicine, Harvard; Medical School, Boston, MA 02215.
It is generally accepted that the lung uptake of 67Ga in patients with pneumocystis carinii pneumonia (PCP) is diffuse and bilateral. Three cases of focal lung uptake of 67Ga in AIDS patients with PCP but without other opportunistic infection are described. While focal lung uptake is characteristic of opportunistic in
Santelli G; Melillo G; Marfella A; Napolitano M; D'Alessio V; Satriano RA; Beth-Giraldo E; Giraldo G; Perna M; Castello G; Sezione di Farmaco e Chemioterapia Sperimentale, Istituto; Nazionale dei Tumori, Napoli, Italy.
We studied neopterin excretion levels and immunological features of 20 patients affected by Kaposi s sarcoma (KS), compared to 30 normal controls. Eighteen patients had the classic form of Kaposi s sarcoma (CKS), while two patients were anti-human immunodeficiency virus (HIV) seropositive and affected by the epidemic
Immunol Lett. 1988 Aug;18(4):247-53. Unique Identifier : AIDSLINE MED/89032450
Maeda M; Noma T; Hama K; Honjo T; Chest Disease Research Institute, Faculty of Medicine, Kyoto; University, Japan.
Interleukin 4 (IL-4) is a multi-functional biological regulator molecule. We developed a simple assay system for human IL-4, using a IL-2-dependent T cell line designated Sez 627 cell line. Sez 627 cells were found to respond only to human IL-4 and human IL-2, but not to other available lymphokines. In combination wit
Shoji S; Tashiro A; Kubota Y; Department of Biochemistry, Faculty of Pharmaceutical Sciences,; Kumamoto University.
N-Myristoyl (N-Myr-) glycinal (aminoacetoaldehyde, GO) diethylacetal (A), which is abbreviated as N-Myr-GOA, and other N-Myr-compounds (N-Myr-Gly-GOA, N-Myr-Gly-Gly-GOA, and N-Myr-Gly-Gly-Gly-GOA) were newly synthesized and then employed for NH2-terminal antimyristoylation of structure proteins in the human T-cell leu
Nishimura M; Adachi A; Maeda M; Akiguchi I; Fujita M; Kameyama M; Ishimoto A; Department of Neurology, Faculty of Medicine, Kyoto University,; Japan.
T cell lines were established from the cerebrospinal fluid (CSF) lymphocytes of three patients with human T lymphotropic virus type I (HTLV-I)-associated myelopathy (HAM). To elucidate the possible changes of the provirus nucleotide sequences integrated in HAM-derived T cell line cells, DNA from these cells was digest
Margolick JB; McArthur JC; Scott ER; McArthur JH; Cohn S; Farzadegan H; Polk BF; Department of Environmental Health Sciences, Johns Hopkins; Medical Institutions, Baltimore, MD 21205.
Two-color flow cytometry was used to analyze T cell subsets (total (CD3), helper-inducer (CD4), and suppressor-cytotoxic (CD8] in paired specimens of cerebrospinal fluid (CSF) and peripheral blood of 66 homosexual men, including 62 with antibodies to human immunodeficiency virus, type 1 (HIV-1). With the exception of
Jeang KT; Boros I; Brady J; Radonovich M; Khoury G; Laboratory of Molecular Virology, National Cancer Institute,; Bethesda, Maryland 20892.
Transcriptional activation of the human T-cell leukemia virus type I (HTLV-I) long terminal repeat (LTR) by viral protein p40x requires a 21-base-pair (bp) sequence which is repeated three times within the LTR. This sequence contains a core octanucleotide (TGACGTCT) which has been attributed to be a cyclic-AMP (cAMP)-
JAMA. 1988 Nov 25;260(20):3009-15. Unique Identifier : AIDSLINE MED/89037529
Creagh-Kirk T; Doi P; Andrews E; Nusinoff-Lehrman S; Tilson H; Hoth D; Barry DW; Burroughs Wellcome Co. Research Triangle Park, NC 27709.
Through a compassionate plea program (Treatment Investigational New Drug), 4805 patients with acquired immunodeficiency syndrome who previously had experienced Pneumocystis carinii pneumonia (PCP) received zidovudine (Retrovir, formerly azidothymidine). Overall survival at 44 weeks after initiation of therapy was 73%
Thromb Haemost. 1988 Aug 30;60(1):97-101. Unique Identifier : AIDSLINE MED/89044716
Williams MD; al-Rubei K; Hill FG; Department of Haematology, Children's Hospital, Birmingham, UK.
Fifty-seven haemophilic boys have been studied prospectively determining T lymphocyte subsets and haematological parameters over a period of 26 months. Clinical follow up of these patients has continued for a further 41 months. At the beginning of the study 21 boys were HIV antibody seropositive and seroconversion was
Tateno M; Levy JA; Department of Medicine, University of California, School of; Medicine, San Francisco 94143.
Using the MT-4 plaque assay, differences in the plaque-forming ability among various isolates of the human immunodeficiency virus (HIV) were observed. Kinetic studies showed that these differences reflected the enhanced ability of individual HIV to replicate rapidly in T cells and cause cytopathic changes. The plaque-
Lee VW; Rosen MP; Baum A; Cohen SE; Cooley TP; Liebman HA; Department of Radiology, Boston City Hospital, Boston University; School of Medicine, MA 02118.
No simple, noninvasive method is available for evaluating extracutaneous Kaposi sarcoma in AIDS patients or for following the tumor s response to treatment. We report our preliminary experience with thallium-201 scintigraphy in nine AIDS patients with proved Kaposi sarcoma. Eight of the nine had abnormal uptake of the
Am J Gastroenterol. 1988 Nov;83(11):1306-8. Unique Identifier : AIDSLINE MED/89047333
Van Calck M; Motte S; Rickaert F; Serruys E; Adler M; Wybran J; Medico-Surgical Department of Gastroenterology, Hopital Erasme,; Universite Libre de Bruxelles, Belgium.
We report the case of an African patient with acquired immune deficiency syndrome (AIDS) who had a chronic cryptococcal rectal abscess with anal fistula and a disseminated neurologic and bony fungal disease, associated with pulmonary infiltration due to Pneumocystis carinii. The anal lesion was surgically excised beca
Mills J; Leoung G; Medina I; Hopewell PC; Hughes WT; Wofsy C; Medical Service, San Francisco General Hospital Center Medical; Center, California.
All patients with the acquired immunodeficiency syndrome treated for their first episode of Pneumocystis carinii pneumonia at San Francisco General Hospital between 1 April 1985 and 15 July 1985 were evaluated for their response to treatment with dapsone (100 mg/day) by mouth for 21 days. Of 44 patients evaluated, 18
Rousselet MC; Audouin J; Le Tourneau A; Bouchard I; Espinoza P; Kazatchkine M; Diebold J; Service Central J. Delarue d'Anatomie et de Cytologie; Pathologiques, Hotel-Dieu, Paris, France.
Some cases of idiopathic thrombocytopenic purpura (ITP) may be related to the prodromal phase of the acquired immunodeficiency syndrome (AIDS). The morphologic features of six spleens removed in this context were studied. In the white pulp, lymphoid follicular hyperplasia was constant but hardly distinguishable from t
Berkman SA; Department of Medicine, UCLA School of Medicine 90024.
Numerous infectious diseases are transmissible by blood, with AIDS and hepatitis being the predominant concerns today. Less in the limelight, but nonetheless blood transmissible, are cytomegalovirus infection, malaria, babesiosis, and hepatitis B. A major controversy with respect t
Crit Care Clin. 1988 Oct;4(4):711-33. Unique Identifier : AIDSLINE MED/89027791
Hauser GJ; Holbrook PR; Department of Critical Care Medicine, Children's Hospital; National Medical Center, Washington, D.C.
Factors contributing to the high prevalence of immunodeficiency in the PICU population include conditions that lead to frequent requirement of intensive care, suppression of immunity secondary to an acute insult, and iatrogenic measures. The immunodeficiency observed in the critically ill correlates well with their su
Weisberg LA; Garcia C; Stazio A; Department of Neurology and Psychiatry, Tulane Medical School,; New Orleans, LA 70112.
The involvement of the CNS in patients with AIDS is frequent such that 80 percent of patients have evidence of CNS disease at autopsy. The clinical manifestations are quite varied. These disorders may be divided into two groups: (1) direct effect of the human immunodeficiency virus (HIV) on the nervous system, for exa
Cancer Detect Prev. 1988;12(1-6):169-74. Unique Identifier : AIDSLINE MED/89028457
Biggar RJ; Environmental Epidemiology Branch, National Cancer Institute,; Bethesda, MD 20892.
AIDS has emerged as one of the foremost infectious disease epidemics of the twentieth century. This review summarizes the magnitude of the AIDS problem and the frequency of infection with the causative agent, the human immunodeficiency virus (HIV). The natural history of HIV infection suggests that a high proportion o
Cancer Detect Prev. 1988;12(1-6):175-80. Unique Identifier : AIDSLINE MED/89028458
Gluckman JC; Klatzmann D; Laboratoire de Biologie et Genetique des Deficits; Immunitaires, UFR Pitie-Salpetriere, Paris, France.
AIDS is primarily a disease of the CD4-expressing helper-inducer T lymphocytes and is caused by human immunodeficiency virus (HIV), a retrovirus of the lentivirus subgroup. The interaction of HIV envelope glycoprotein (gp 110) with the CD4 molecule itself accounts for the virus selective tropism and for its pathogenic
Cancer Detect Prev. 1988;12(1-6):195-203. Unique Identifier : AIDSLINE MED/89028460
Pekovic DD; Gornitsky M; Garzon S; Strykowski H; Adamkiewicz VW; Zwadlo G; Ajdukovic D; AIDS Research Center, Soficorp Scientific, Montreal, Canada.
HIV antigens were identified in PBL obtained from HIV-positive patients, using IF and IEM. Studies of the phenotype of HIV-containing lymphocytes showed that OKT4+ cells were the principal target of the virus. Approximately 5% of infected cells were multinucleated. Almost all infected and about 30% of uninfected PBL d
Warren RQ; Johnson EA; Donnelly RP; Lavia MF; Tsang KY; Department of Microbiology and Immunology, Medical University of; South Carolina, Charleston 29425.
The presence and specificity of anti-lymphocyte antibodies (ALA) was investigated in sera from male homosexuals with AIDS-Related Complex (ARC) as well as healthy homosexuals. Individuals in the healthy homosexual group had no detectable antibodies to human immunodeficiency virus (HIV). Antibodies reactive with normal
Markowski MA; Coard JG; Griffith B; Mayo DR; Virology Laboratory, State Department of Health Services,; Hartford, CT 06144.
One hundred and thirty-five sera were tested for the presence of antibody to human immunodeficiency virus (HIV) by enzyme immunoassay (EIA) with the Abbott Diagnostics HTLV-III test before and after heating at 56 degrees C for 10 min. Only one serum specimen was repeatedly reactive after heating when compared with the
Muller F; Gromm M; Muller KH; Medizinaluntersuchungsanstalt, Hygienisches Institut Hamburg.
Two techniques for detection of anti-HIV-1 antibodies were comparatively investigated. It is shown that the particle agglutination (PA) is at least equivalent to the enzyme immunoassay (EIA) as far as sensitivity is concerned. A ten-fold increased sensitivity of PA was found when compared with Western Blot results. Fu
Haffar OK; Dowbenko DJ; Berman PW; Department of Molecular Biology, Genentech, Inc., South San; Francisco, California 94080.
The orientation in cellular membranes of the 856 amino acid envelope glycoprotein precursor, gp160, of human immunodeficiency virus type 1 was investigated in vitro. Variants of the env gene were transcribed using the bacteriophage SP6 promoter, translated using a rabbit reticulocyte lysate, and translocated into cani
Ruane PJ; Walker LJ; George WL; Medical Services, West Los Angeles Veterans Administration; Medical Center, California 90073.
We report a case of fungemia and disseminated disease caused by a urease-negative strain of Cryptococcus neoformans in a patient with the acquired immune deficiency syndrome. Except for failure to hydrolyze urea, the microbiological characteristics of the isolate were typical of C. neoformans. Laboratory specialists s
Hoy JF; Lewis DE; Miller GG; Program in Infectious Diseases and Clinical Microbiology,; University of Texas Medical School, Houston.
We performed a prospective study of 50 subjects at high risk for human immunodeficiency virus (HIV) infection to determine if assays of antigen-specific T cell function provide an earlier indication of future progression to AIDS or a better assessment of immune function than do current methods of evaluation. We measur
J Med Virol. 1988 Sep;26(1):23-32. Unique Identifier : AIDSLINE MED/89036177
Ehrnst A; Sonnerborg A; Bergdahl S; Strannegard O; Central Microbiological Laboratory, Stockholm County Council,; Sweden.
Attempts to isolate human immunodeficiency virus (HIV) from blood plasma using inoculation of pellets from ultracentrifuged samples into cultures of peripheral blood mononuclear cells (PBMC) resulted in a high overall recovery rate (75%) of the virus from 76 patients in various stages of HIV infection. The recovery ra
J Med Virol. 1988 Sep;26(1):41-8. Unique Identifier : AIDSLINE MED/89036179
Kovamees J; Sheshberadaran H; Chiodi F; Schwartz S; Orvell C; Fenyo EM; Norrby E; Department of Virology, Karolinska Institute, Stockholm, Sweden.
Sera from 31 human immunodeficiency virus (HIV)-infected patients, representing different clinical stages of HIV infection, were assayed for antibodies against measles and mumps viruses by various serological tests and compared to 23 healthy controls. Sera from four patients (two primary, one asymptomatic, and one acq
Catalan J; Oxford University Department of Psychiatry, Warneford Hospital.
HIV infection in general and AIDS in particular, present a major challenge for the health services worldwide. The possibility of central nervous system effects of HIV infection has been known for some time, and information is now accumulating about the range of psychiatric disorders associated with it. This paper cons
JAMA. 1988 Dec 9;260(22):3286-9. Unique Identifier : AIDSLINE MED/89037596
Widy-Wirski R; Berkley S; Downing R; Okware S; Recine U; Mugerwa R; Lwegaba A; Sempala S; AIDS Control Programme, Ministry of Health and World Health; Organization, Entebbe, Uganda.
Infections with human immunodeficiency virus are common in areas of the world where laboratory testing and sophisticated diagnostic facilities are unavailable. A World Health Organization clinical case definition for acquired immunodeficiency syndrome was developed in 1985 for use in s
Medicine (Baltimore). 1988 Nov;67(6):401-22. Unique Identifier : AIDSLINE MED/89039241
Ratner L; Poiesz BJ; Division of Hematology and Oncology, Washington University, St.; Louis, Missouri 63110.
Human T lymphotropic virus type 1 (HTLV-I) is a retrovirus which is prevalent in southern Japan , the Caribbean Basin, and Africa. Recent seroprevalence studies in the United States suggest that there are about 50,000 infected individuals. The identif
Stadler R; Bratzke B; Mayer da Silva A; Orfanos CE; Universitats-Hautklinik und Poliklinik, Klinikum Steglitz der; Freien Universitat Berlin.
Since 1980, disseminated Kaposi s sarcoma has been occurring in new epidemic proportions with a rapid clinical course in risk populations. Sixteen cases were under therapy and close surveillance from 1982 to 1986. Eight are still under therapy. In disseminated Kaposi s sarcoma with acquired immune deficiency syndrome
Yap PL; Williams PE; Edinburgh Blood Transfusion Service, UK.
Patients with the acquired immunodeficiency syndrome (AIDS) suffer from a deficiency of cellular immunity. However, some HIV-infected children and adults suffer from recurrent upper respiratory tract infections suggestive of a failure to synthesise specific antibodies, despite the hypergammaglobulinaemia that is prese
Jackson S; Department of Microbiology, University of Alabama, Birmingham; 35294.
IgA nephropathy (IgAN) is characterized by mesangial co-deposition of IgA and C3. Elevated levels of circulating immune complexes containing these components in significant numbers of patients have been found in several studies; IgAN is therefore assumed by many investigators to be an immune complex-mediated disease.
Ann Intern Med. 1988 Dec 1;109(11):855-62. Unique Identifier : AIDSLINE MED/89048676
Lukehart SA; Hook EW 3d; Baker-Zander SA; Collier AC; Critchlow CW; Handsfield HH; University of Washington, Seattle.
STUDY OBJECTIVES: To determine the prevalence of Treponema pallidum in cerebrospinal fluid (CSF) of patients with syphilis, to determine the effect of concurrent HIV infection on central nervous system involvement by T. pallidum, and to examine the efficacy of conventional therapy for asymptomatic neurologic involveme
Ann N Y Acad Sci. 1988;538:60-8. Unique Identifier : AIDSLINE MED/89048777
Van Baelen H; Allewaert K; Bouillon R; Laboratory for Experimental Medicine and Endocrinology, Onderwijs; en Navorsing, Campus Gasthuisberg, Leuven, Belgium.
Santucci M; Pimpinelli N; Moretti S; Giannotti B; Istituto di Anatomia e Istologia Patologica, Universita degli; Studi di Firenze, Italy.
The evolutionary modifications of the clinical, histomorphologic, and immunopathologic features of both classic and immunodeficiency (ID)-associated Kaposi s sarcoma (KS) were investigated in relation to the immune status of the patients. The histologic picture was similar in the classic and ID-associated forms of the
Blumenfeld W; Kovacs JA; Department of Laboratory Medicine, Veterans Administration; Medical Center, San Francisco.
We evaluated the utility of a monoclonal antibody that recognizes Pneumocystis carinii as a diagnostic tool in specimens of bronchoalveolar lavage fluid and sputum from patients in whom a diagnosis of P carinii pneumonia was being considered. In addition to routine processing for diagnosis by morphologic recognition o
Mann JM; Nzilambi N; Piot P; Bosenge N; Kalala M; Francis H; Colebunders RC; Azila PK; Curran JW; Quinn TC; AIDS Program, Centers for Disease Control, Atlanta, Georgia.
In Africa, female prostitutes represent a high risk group for HIV infection. In Kinshasa, Zaire , 101 (27%) out of 377 prostitutes were seropositive to HIV by ELISA and Western blot determination. Seropositivity was significantly associated with the number of lifetime partners with
Hudson CP; Hennis AJ; Kataaha P; Lloyd G; Moore AT; Sutehall GM; Whetstone R; Wreghitt T; Karpas A; School of Clinical Medicine, University of Cambridge.
Before commencing rational control programmes for AIDS in Africa it is desirable to determine the relative importance of heterosexual and various non-sexual modes of transmission. We investigated this by comparing the seroepidemiologies of AIDS, hepatitis B and syphilis at two rural hospitals in southwest
Selwyn PA; Feingold AR; Hartel D; Schoenbaum EE; Alderman MH; Klein RS; Friedland GH; Department of Epidemiology and Social Medicine, Montefiore; Medical Center, Bronx, New York 10467.
Although patients with AIDS have been noted to be at risk for bacterial pneumonia as well as opportunistic infections, little is known about the risk of bacterial pneumonia in HIV-infected populations without AIDS. To determine the incidence of bacterial pneumonia in a well defined population of intravenous drug users
Jendis JB; Tomasik Z; Hunziker U; Nadal D; Seger R; Wetzel JC; Kind C; Schupbach J; Swiss National Center for Retroviruses, University of Zurich,; Switzerland.
Children born to HIV-infected women in Switzerland were tested every 3 months for HIV-reactive serum immunoglobulin (Ig) G, IgM and IgA antibodies by Western blot, viral antigen, virus replicating in T-lymphocyte cultures, and immunologic and clinical parameters. At birth, 27%
Bredberg-Raden U; Kiango J; Mhalu F; Biberfeld G; Department of Immunology, National Bacteriological Laboratory,; Stockholm, Sweden.
Sera from 622 blood donors collected in 1986 and 1987 in Tanzania were screened for antibodies to HIV-1 by seven different commercial enzyme-linked immunosorbent assay (ELISA) kits. All ELISA-positive sera were tested by Western blot analysis and many of them also by radioimmunop
Tenner-Racz K; Racz P; Schmidt H; Dietrich M; Kern P; Louie A; Gartner S; Popovic M; Department of Haematology, Allgemeines Krankenhaus St George,; Hamburg, Federal Republic of Germany.
To investigate the role of the lymphatic vessels and the sinus systems of the lymph node in the spread of HIV-1, we evaluated 15 lymph nodes from patients with persistent generalized lymphadenopathy (PGL). Fifteen lymph nodes taken from patients with follicular hyperplasia not related to HIV-1 infection served as cont
Klasse PJ; Berntorp E; Hansson BG; Department of Medical Microbiology, University of Lund, Malmo,; Sweden.
The immunoglobulin (lg) G subclass response against HIV was investigated in sera from 13 haemophiliacs and 21 non-haemophiliacs. Monoclonal antibodies specific for the human lgG subclasses were used in an enzyme immunoblot assay, which was evaluated densitometrically. Seven of the haemophiliacs had detectable lgG4 ant
Dawson S; Evans BA; Lawrence AG; Department of Genitourinary Medicine, West London, Hospital, UK.
Benign tertiary (gummatous) syphilis has virtually disappeared [1]. Two homosexual men with gummata have presented to genitourinary medicine clinics in west London in recent months. They both had antibodies to HIV. It is possible that otherwise adequately treated syphilis has progressed to the tertiary stage as a cons
Cancer Detect Prev. 1988;12(1-6):537-52. Unique Identifier : AIDSLINE MED/89028503
Hadden JW; Program of Immunopharmacology, University of South Florida; Medical College, Tampa 33612.
Interleukin-2 ( IL-2 ) is a chemically defined lymphokine (LK) available as mixed human (LK) preparations, as partially purified lymphoblastoid IL-2, or as recombinant human IL-2. Each has different actions dependent on companion LKs showing synergistic interaction (e.g.
Ukkonen P; Korpela J; Suni J; Hedman K; Department of Virology, University of Helsinki, Finland.
Since the human immunodeficiency virus (HIV) may be transmitted accidentally to laboratory personnel analyzing patient sera, the efficiency of a non-ionic detergent, Triton X-100, in inactivation of HIV in human serum as a safety measure was studied. Semliki Forest virus, an enveloped toga virus, was used as a model v
Leon P; Lopez JA; Contreras G; Echevarria JM; Centro Nacional de Microbiologia, Virologia e Inmunologia; Sanitarias, Madrid, Spain.
In a study to determine the incidence of infection with hepatitis delta virus (HDV) in high-risk groups in Spain , tests to detect serological markers of infection with hepatitis B virus (HBV) and total antibodies against HDV (anti-HDV) were performed in serum samples from 451 unsele
Up to 30% of patients with acquired immunodeficiency syndrome (AIDS) suffer from Kaposi s sarcoma (AIDS-KS). The histogenesis and neoplastic nature of this tumor is still controversial. We have established cell cultures of KS biopsies from 7 patients with AIDS. All donors were seropositive for the human immunodeficien
McHugh TM; Stites DP; Busch MP; Krowka JF; Stricker RB; Hollander H; Department of Laboratory Medicine, University of California, San; Francisco 94143.
Weisser J; Padiatrische/neuropadiatrische Abteilung, Rehabilitationsklinik; fur Kinder und Jugendliche, Neckargemund.
Short presentation of the common procedures to avoid transmission of human-immunodeficiency-virus (HIV) by hemoderivates especially clotting-factor-preparations. The stepwise seroconversion (ELISA, IFT, Western-blot) of HIV is shown in a 7 5/12 ys old boy with hemophilia A after administration of a dry-heated factor V
Schutt KH; Arndt-Hanser A; Transfusionszentrale der Universitatskliniken Mainz.
The risk of transmitting infectious agents through homologous blood transfusions can t be completely eliminated. According to our present knowledge, the posttransfusion-hepatitis (PTH) type B has been overestimated till the end of the seventies. Concerning PTH type Non A Non B special serological diagnostic techniques
N Z Med J. 1988 Oct 26;101(856 Pt 2):709-11. Unique Identifier : AIDSLINE MED/89040770
Ellis-Pegler RB; Auckland Hospital.
Predicting the behaviour of infectious disease is particularly difficult because it is inextricably linked with microbial mutation and the potentially rapid expression of that change. Nevertheless, the dominant issue in infectious disease in New Zealand into the 1990s, and perh
Thromb Haemost. 1988 Jun 16;59(3):396-9. Unique Identifier : AIDSLINE MED/89044657
Wolfs TF; Breederveld C; Krone WJ; v.d. Hoek L; Bakker M; Smit L; Goudsmit J; Department of Virology, Academic Medical Centre of the University; of Amsterdam, The Netherlands.
A national multicentre study was performed to investigate the effects of donorselection and the use of heat-treated plasma products on seroconversion to HIV in 157 Dutch haemophiliacs. All patients included in the study were seronegative for HIV antibodies in 1983. Thirteen percent (20/157) seroconverted between 1983
Trans R Soc Trop Med Hyg. 1988;82(2):262. Unique Identifier : AIDSLINE MED/89045069
de Lima e Costa MF; Proietti FA; Paulino UH; Antunes CM; Guimaraes MD; Rocha RS; Katz N; Grupo Interdepartamental de Pesquisas em Epidemiologia,; Universidade Federal de Minas Gerais, Belo Horizonte, M.G.,; Brazil.
Am J Hematol. 1988 Oct;29(2):94-105. Unique Identifier : AIDSLINE MED/89047381
Perkocha LA; Rodgers GM; Department of Laboratory Medicine, San Francisco General; Hospital.
Hematologic abnormalities are common in patients with HIV infection. This review will focus on HIV-associated cytopenias and coagulation abnormalities. Their occurrence, laboratory evaluation, and clinical significance and the mechanisms underlying their development are discussed. Therapeutic modalities are presented,
Clarkson AB Jr; Williams DE; Rosenberg C; Department of Medical and Molecular Parasitology, New York; University Medical Center, New York 10016.
Pneumocystis carinii pneumonia is often the terminal event for patients with the acquired immunodeficiency syndrome. Eflornithine (DL-alpha-difluoromethylornithine [DFMO]; Ornidyl; Merrell Dow Research Institute, Cincinnati, Ohio) has been used successfully against this protozoan disease in limited clinical trials, al
del Rio C; Guarner J; Honig EG; Slade BA; Department of Medicine, Emory University School of Medicine,; Atlanta, GA.
To examine the role of sputum examination in the diagnosis of Pneumocystis carinii pneumonia in patients with the acquired immunodeficiency syndrome (AIDS), we conducted a prospective study of 30 patients with AIDS or suspected AIDS. Sputum was obtained just prior to bronchoscopy by spontaneous cough (20 patients) or
JAMA. 1988 Nov 11;260(18):2694-7. Unique Identifier : AIDSLINE MED/89037481
Kaplan JE; Spira TJ; Fishbein DB; Bozeman LH; Pinsky PF; Schonberger LB; Division of Viral Diseases, Centers for Disease Control, Atlanta,; GA 30333.
Seventy-five homosexual men with generalized lymphadenopathy for at least three months (lymphadenopathy syndrome [LAS]), subsequently shown to be seropositive for antibody against human immunodeficiency virus, were enrolled in a prospective study in Atlanta in 1982 and 1983. As of Nov 30, 1987, twenty-two (29%) of the
JAMA. 1988 Nov 25;260(20):3045-8. Unique Identifier : AIDSLINE MED/89037536
Pottage JC Jr; Benson CA; Spear JB; Landay AL; Kessler HA; Department of Internal Medicine, Rush-Presbyterian-St Luke's; Medical Center, Chicago, IL 60612.
Human immunodeficiency virus (HIV)-related thrombocytopenia has been well described and requires therapy in about one half of the patients. Conventional modes of therapy with prednisone, danazol, immunoglobulin, and/or splenectomy have not been uniformly successful. We have administered zidovudine to three patients wi
Shirono K; Hattori T; Matsuoka M; Matsushita S; Asou N; Takatsuki K; Second Department of Internal Medicine, Kumamoto University; Medical School, Japan.
Surface phenotypes and genotypes of six T cell lines established from four patients with adult T cell leukemia (ATL) were compared with those of fresh ATL cells. The surface antigen densities of CD3 and T cell receptor (TCR) complex examined by OKT3 and WT-31 mAbs on fresh ATL cells were low. But three IL-2-dependent
Murrah VA; Scholtes GA; Department of Oral Diagnosis and Radiology, University of; Minnesota School of Dentistry, Minneapolis.
Two hundred six dental patients were tested between 1985 and 1987 for antibodies to human immunodeficiency virus (HIV) when a review of their medical histories revealed a high risk for infection. Serologic results are correlated with soft tissue and osseous findings recorded during routine head and neck and radiograph
Ann Intern Med. 1988 Dec 1;109(11):874-9. Unique Identifier : AIDSLINE MED/89048679
Ognibene FP; Masur H; Rogers P; Travis WD; Suffredini AF; Feuerstein I; Gill VJ; Baird BF; Carrasquillo JA; Parrillo JE; et al; Clinical Center, National Institutes of Health, Bethesda,; Maryland.
STUDY OBJECTIVE: To assess how often Pneumocystis carinii organisms, P. carinii pneumonia, or other pulmonary pathologic processes were present in persons infected with human immunodeficiency virus (HIV) without pulmonary symptoms or previous history of P. carinii, and with a normal chest roentgenogram. DESIGN: Serial
Waldmann TA; Goldman CK; Bongiovanni KF; Sharrow SO; Davey MP; Cease KB; Greenberg SJ; Longo DL; Metabolism Branch, National Cancer Institute, Bethesda, MD 20892.
Human T-cell lymphotropic virus I (HTLV-I)-induced adult T-cell leukemia (ATL) cells constitutively express interleukin-2 ( IL-2 ) receptors identified by the anti-Tac monoclonal antibody (MoAb), whereas normal resting cells do not. This observation provided the scientif
Estep TN; Bechtel MK; Miller TJ; Bagdasarian A; Travenol Laboratories, Inc., Round Lake, Illinois 60073.
To determine the feasibility of heat treating hemoglobin solutions to inactivate viruses, we performed experiments on the thermal stability of this protein and found that the structure and function of deoxyhemoglobin are well preserved during incubation at 60 degrees C for 10 hours at a pH of 7.5. Model viruses and th
FEBS Lett. 1988 Oct 24;239(1):88-92. Unique Identifier : AIDSLINE MED/89031225
Sinangil F; Loyter A; Volsky DJ; Molecular Virology Laboratory, St. Luke's/Roosevelt Hospital; Center and Columbia University, New York, NY 10019.
Human immunodeficiency virus (HIV) was purified by sucrose gradient centrifugation and labeled with octadecylrhodamine B-chloride (R-18) under conditions resulting in 90% quenching of the fluorescence label. Incubation of R-18-labeled HIV (R-18/HIV) with CD4-positive CEM and HUT-102 cells, but not with CD4-negative ML
FASEB J. 1988 Nov;2(14):2970-81. Unique Identifier : AIDSLINE MED/89031730
Johnson RT; McArthur JC; Narayan O; Department of Neurology, Johns Hopkins Medical Institutions,; Baltimore, Maryland 21205.
A variety of diseases of the central and peripheral nervous systems evolves during the course of human immunodeficiency virus (HIV) infections. Most are not related to documented opportunistic infections and may be the direct result of HIV infections, as large proportions of healthy and ill HIV-infected persons show e
Uhnoo I; Dharakul T; Riepenhoff-Talty M; Ogra PL; Department of Pediatrics, State University of New York, Buffalo.
Rotaviruses are important pathogens causing severe diarrhoea in human infants and young animals. Available information on the pathogenic mechanisms of and the immune response to rotaviruses is reviewed here. Studies in our laboratory using the suckling mouse model have focused on elucidating the nature of interaction
Howell RE; Albelda SM; Daise ML; Levine EM; Department of Medicine, University of Pennsylvania, Philadelphia.
We used radioligand binding methods to characterize beta-adrenergic receptors on endothelial cells cultured from adult human iliac vein (HIVE) and bovine fetal aorta (BFAE). For comparison, we also studied the well-characterized C6 glioma cell line (C6). Both human and bovine endothelial cells showed specific saturabl
Krueger GR; Koch B; Ramon A; Ablashi DV; Salahuddin SZ; Josephs SF; Streicher HZ; Gallo RC; Habermann U; Immunopathology Section, University of Cologne, F.R.G.
Detailed serologic screening showed an antibody prevalence to HBLV (HHV-6) in the general population of 26% if very strict criteria for antibody positivity were applied. Lower and borderline antibody titers yet may be found in up to 63% of the population. Only 17% of these persons have clinical symptoms; in the majori
500 sera representing healthy blood donors and a random representation of the U.S. population collected 10 years ago were screened by ELISA for antibody reactivity with purified, disrupted HBLV virions. In each group, the ELISA results were normally distributed with no evidence of bimodality. All sera were subsequentl
Pagano JS; Kenney S; Markovitz D; Kamine J; Department of Medicine, University of North Carolina, Chapel Hill; 27599.
There is accumulating evidence for interaction of Epstein-Barr virus (EBV) and human immunodeficiency virus (HIV): EBV and HIV may coinfect B-lymphocytes; the prevalence of active EBV is increased in active homosexuals; and EBV-related B-cell lymphomas occur frequently in AIDS patients. We have shown that cord-blood B
Viza D; Vich JM; Minarro A; Ablashi DV; Salahuddin SZ; Laboratoire d'Immunobiologie, Faculte de Medecine, Paris,; France.
Nineteen Macaca fascicularis monkeys were injected with SIV. They were subsequently divided into 5 groups. Four groups of 4 animals were injected with dialysable extracts (DLE) from a lymphoblastoid cell line which had been previously induced with DLE obtained either from the total lymphocyte population, or from the C
Ablashi DV; Josephs SF; Buchbinder A; Hellman K; Nakamura S; Llana T; Lusso P; Kaplan M; Dahlberg J; Memon S; et al; Laboratory of Cellular and Molecular Biology, National Cancer; Institute, Bethesda, MD.
Human B-lymphotropic virus (HBLV), also known as human herpesvirus-6 (HHV-6) was first isolated in 1986 from AIDS patients and patients with other lymphoproliferative disorders. HBLV is distinct from known human herpesviruses, biologically, immunologically and by molecular analysis. HBLV can infect and replicate in fr
J Immunol. 1988 Nov 15;141(10):3611-6. Unique Identifier : AIDSLINE MED/89035489
Pitha PM; Biegel D; Yetter RA; Morse HC 3d; Johns Hopkins University Oncology Center, Baltimore, MD 21205.
Mice infected with LP-BM5 murine leukemia viruses (MuLV) develop a syndrome with many features in common with AIDS including lymphadenopathy and profound immunodeficiency associated with enhanced susceptibility to infection and terminal B cell lymphomas. To evaluate cellular defects that may predispose infected mice t
J Immunol. 1988 Dec 1;141(11):3715-7. Unique Identifier : AIDSLINE MED/89035502
Diamond DC; Sleckman BP; Gregory T; Lasky LA; Greenstein JL; Burakoff SJ; Division of Pediatric Oncology, Dana-Farber Cancer Institute,; Boston, MA 02115.
The CD4 molecule is functionally involved in the class II MHC-restricted T cell response to Ag. CD4 is also the receptor for HIV-1, the major etiologic agent of AIDS. We have assessed whether the interaction of the HIV-1 envelope protein with the CD4 molecule might interfere with the normal function of CD4, thereby co
Martin LS; Spira TJ; Orloff SL; Holman RC; Division of Host Factors, Centers for Disease Control, Atlanta,; Georgia 30333.
We evaluated the ability of normal human peripheral blood monocytes and polymorphonuclear leucocytes (PMNL) isolated from patients with acquired immunodeficiency syndrome (AIDS) or AIDS-related conditions (ARC) to migrate toward a chemoattractant. Migration in blind-well chambers was compared to that under agarose. Ch
Ohta M; Nyunoya H; Tanaka H; Okamoto T; Akagi T; Shimotohno K; Virology Division, National Cancer Center Research Institute,; Tokyo, Japan.
The X gene products of the human T-cell leukemia viruses type I and II are thought to be involved not only in viral replication but also in mediating the expression of certain cellular genes. These X gene products are known to be translated from doubly spliced viral mRNA, while viral structural proteins, such as the g
Viglianti GA; Mullins JI; Department of Cancer Biology, Harvard School of Public Health,; Boston, Massachusetts 02115.
Simian immunodeficiency virus from rhesus macaques (SIVmac), like human immunodeficiency virus type 1 (HIV-1), encodes a transactivator (tat) which stimulates long terminal repeat (LTR)-directed gene expression. We performed cotransfection assays of SIVmac and HIV-1 tat constructs with LTR-CAT reporter plasmids. The p
Naidu YM; Kestler HW 3d; Li Y; Butler CV; Silva DP; Schmidt DK; Troup CD; Sehgal PK; Sonigo P; Daniel MD; et al; New England Regional Primate Research Center, Harvard Medical; School, Southborough, Massachusetts 01772.
Infection of macaque monkeys with simian immunodeficiency virus (SIV) is probably the best animal model currently available for studying acquired immunodeficiency syndrome. In this report, we describe three infectious molecular clones of SIVmac and one of human immunodeficiency virus type 2 (HIV-2) and their use in th
Hauber J; Bouvier M; Malim MH; Cullen BR; Howard Hughes Medical Institute, Duke University Medical Center,; Durham, North Carolina 27710.
Replication of human immunodeficiency virus type 1 requires the functional expression in trans of the virally encoded rev gene product (previously called art/trs). Here we demonstrate that this protein can be metabolically labeled with 32Pi. The phosphate receptor in the rev protein is shown to be exclusively serine.
Montanari M; Divisione Malattie Infettive, Ospedale di Circolo e Fondazione E.; e S. Macchi, Varese.
The clinical aspects of gastrointestinal pathologies in 21 AIDS patients are examined. The study confirms the frequency of gastroenteric alterations in AIDS.
Proc Natl Acad Sci U S A. 1988 Nov;85(21):8291-5. Unique Identifier : AIDSLINE MED/89042171
Jeang KT; Shank PR; Kumar A; Laboratory of Molecular Virology, National Cancer Institute,; Bethesda, MD 20892.
The genomes of human retroviruses [human immunodeficiency virus type 1 (HIV-1) and human T-cell leukemia virus (HTLV-I)] encode positive trans-activator proteins, named tat. In the presence of tat, the transcriptional activity of the homologous HIV-1 or HTLV-I long terminal repeat (LTR) promoter is markedly increased.
Proc Natl Acad Sci U S A. 1988 Nov;85(22):8526-30. Unique Identifier : AIDSLINE MED/89042214
Fujii M; Sassone-Corsi P; Verma IM; Molecular Biology and Virology Laboratory, Salk Institute, San; Diego, CA 92138.
To understand the mechanisms of oncogenesis by human T-cell leukemia virus type I, we have investigated the ability of the tax1, protein to modulate transcription of protooncogenes. By using a transient cotransfection assay, we report that the protooncogene fos promoter is transactivated by tax1 in a variety of cell t
Rook AH; Department of Dermatology, Hospital of the University of; Pennsylvania, Philadelphia 19104.
Infection of the normal host with human cytomegalovirus (HCMV) is followed by both humoral and cellular immune responses against this herpesvirus. The importance of cell-mediated immunity against HCMV is exemplified by the occurrence of severe and prolonged HCMV infections in indiv
Buhles WC Jr; Mastre BJ; Tinker AJ; Strand V; Koretz SH; Institute of Clinical Medicine, Syntex Research, Palo Alto,; California 94303.
A total of 314 immunocompromised patients with serious cytomegalovirus ( CMV ) infection treated with ganciclovir administered intravenously were studied. Rates of favorable clinical response among evaluatable patients were 91
Palestine AG; Laboratory of Immunology, National Eye Institute, Bethesda,; Maryland 20892.
Cytomegalovirus ( CMV ) retinitis is a sight-threatening opportunistic infection of the retina that occurs in immunosuppressed individuals. The diagnosis is based primarily on the clinical ophthalmic examination, with laboratory confirmation of systemic CMV infect
Mills J; Jacobson MA; O'Donnell JJ; Cederberg D; Holland GN; San Francisco General Hospital, California 94110.
Retinitis is the commonest clinical manifestation of cytomegalovirus ( CMV ) infection in patients with AIDS. Untreated patients generally experience progressive involvement of the retina, which may result in blindness. Attempt
Dieterich DT; Chachoua A; Lafleur F; Worrell C; Kaplan Cancer Center, New York University Medical Center, New; York 10016.
Ganciclovir (DHPG) treatment of 69 AIDS patients with gastrointestinal infection due to cytomegalovirus ( CMV ) was studied. Sites of infection included the colon (46 patients, 67%), esophagus and stomach (15 patients, 22%), re
Crumpacker C; Marlowe S; Zhang JL; Abrams S; Watkins P; Department of Medicine, Beth Israel Hospital, Boston,; Massachusetts 02215.
In a multicenter uncontrolled trial of ganciclovir therapy for well-documented cytomegalovirus ( CMV ) pneumonia in 21 patients following bone marrow transplantation, eight (38%) of 21 survived for more than 90 days. Two additi
Winston DJ; Ho WG; Bartoni K; Holland GN; Mitsuyasu RT; Gale RP; Busuttil RW; Champlin RE; Department of Medicine, UCLA Medical Center 90024.
The efficacy and safety of ganciclovir were evaluated for the treatment of 39 life-threatening or sight-threatening cytomegalovirus ( CMV ) infections in recipients of bone marrow transplants (15 patients), recipients of liver
Science. 1988 Nov 25;242(4882):1166-8. Unique Identifier : AIDSLINE MED/89043987
Till MA; Ghetie V; Gregory T; Patzer EJ; Porter JP; Uhr JW; Capon DJ; Vitetta ES; Department of Microbiology, University of Texas Southwestern; Medical Center, Dallas 75235.
The gp120 envelope glycoprotein of the human immunodeficiency virus (HIV), which is expressed on the surface of many HIV-infected cells, binds to the cell surface molecule CD4. Soluble derivatives of recombinant CD4 (rCD4) that bind gp120 with high affinity are attractive vehicles for targeting a cytotoxic reagent to
South Med J. 1988 Nov;81(11):1392-5. Unique Identifier : AIDSLINE MED/89044136
Gould E; Kory WP; Raskin JB; Ibe MJ; Redlhammer DE; Department of Pathology, University of Miami School of Medicine,; Fla. 33101.
We reviewed 20 esophageal biopsy specimens from 180 adult patients with the acquired immunodeficiency syndrome (AIDS). Ten (50%) showed superficial Candida infection, and four revealed esophagitis due to cytomegalovirus . Candida was never invasive, even though it was associated wit
Vet Microbiol. 1988 Jul;17(3):197-218. Unique Identifier : AIDSLINE MED/89045580
Burny A; Cleuter Y; Kettmann R; Mammerickx M; Marbaix G; Portetelle D; van den Broeke A; Willems L; Thomas R; Faculty of Agronomy, Gembloux, Belgium.
Bovine leukaemia virus (BLV) is the etiological agent of chronic lymphatic leukaemia/lymphoma in cows, sheep and goats. Infection without neoplastic transformation was also obtained in pigs, rhesus monkeys, chimpanzees, rabbits and observed in capybaras and water-buffaloes. Structurally and functionally, BLV is a rela
Vet Microbiol. 1988 Jul;17(3):287-96. Unique Identifier : AIDSLINE MED/89045584
Ogilvie GK; Tompkins MB; Tompkins WA; College of Veterinary Medicine, University of Illinois, Urbana.
Cats exposed to the feline leukemia virus (FeLV) may mount an effective immune response and eliminate the virus, develop a non-viremic, latent infection or become persistently infected and shed the virus. Persistently infected cats commonly die of secondary opportunistic infections that result from FeLV-induced immuno
Kingsman SM; Kingsman AJ; Department of Biochemistry, Oxford, UK.
Recombinant DNA technology can be used to produce individual proteins from infectious organisms and these have the potential to be used as subunit vaccines. In many cases however these proteins display a low immunogenicity. One reason for this might be the poor presentation of the antigen to the cells of the immune sy
Dahlberg JE; Laboratory of Cellular and Molecular Biology, National Cancer; Institute, Bethesda, Maryland 20892.
This introductory chapter has presented an overview of how retroviruses replicate and how they are classified within the family Retroviridae. The genomic structure of retroviruses, so reminiscent of bacterial transposons and other similar genetic elements, and reverse transcriptase, which leads to the reverse flow of
Burny A; Cleuter Y; Kettmann R; Mammerickx M; Marbaix G; Portetelle D; Van den Broeke A; Willems L; Thomas R; Faculty of Agronomy, Gembloux, Belgium.
Bovine leukemia virus is the etiological agent of a chronic lymphatic leukemia/lymphoma in cows, sheep, and goats. Infection without neoplastic transformation also was obtained in pigs, rhesus monkeys, chimpanzees, and rabbits, and was observed in capybaras and water buffaloes. Structurally and functionally, BLV is a
Pauwels R; Balzarini J; Schols D; Baba M; Desmyter J; Rosenberg I; Holy A; De Clercq E; Rega Institute for Medical Research, Katholieke Universiteit; Leuven, Belgium.
A study of the structure-activity relationship of a series of newly synthesized phosphonylmethoxyalkyl purine and pyrimidine derivatives revealed that several adenine derivatives substituted at the N9 position by a 2-phosphonylmethoxyethyl (PME) group inhibited human immunodeficiency virus (HIV)-induced cytopathogenic
Rhodes RH; Ward JM; Walker DL; Ross AA; Department of Pathology, Los Angeles County-University of; Southern California Medical Center 90033-1084.
Antigens of human polyomaviruses, the etiologic agents of progressive multifocal leukoencephalopathy (PML), and of human immunodeficiency virus were localized in paraffin sections from brains of six patients who died with the acquired immunodeficiency syndrome. Immunostaining revealed polyomaviral antigens in oligoden
Biochem Biophys Res Commun. 1988 Oct 31;156(2):1046-53. Unique Identifier : AIDSLINE MED/89050080
Vince R; Hua M; Brownell J; Daluge S; Lee FC; Shannon WM; Lavelle GC; Qualls J; Weislow OS; Kiser R; et al; Department of Medicinal Chemistry, College of Pharmacy,; University of Minnesota, Minneapolis 55455.
Carbocyclic 2 ,3 -didehydro-2 ,3 -dideoxyguanosine (Carbovir: NSC 614846), a novel nucleoside analog, emerged as a potent and selective anti-HIV agent from a large screening program conducted by the National Cancer Institute and its contractors. Its hydrolytic stability and its ability to inhibit the infectivity and r
Courouce AM; Institut National de Transfusion Sanguine, Paris, France.
A seroepidemiological surveillance study to investigate the spread of HIV-2 infection in France was organized in the last semester of 1987 on 100 114 blood donors and 10 004 selected people. Sera were simultaneously tested for antibodies to HIV-1 and to HIV-2 by enzyme-linked immun
Lefrere JJ; Courouce AM; Lucotte G; Boitard C; Kaplan C; Nicolas JC; Bricout F; Lambin P; Doinel C; Muller JY; et al; Institut National de Transfusion Sanguine, Paris, France.
Systematic screening of blood donations by enzyme-linked immunosorbent assay (ELISA) for HIV antibodies carries a false-positive rate: the sera involved react in Western blot to core antigens (p24 or p17) but reactivity to envelope is absent. We studied 22 subjects with persistent and isolated anti-core reactivities;
Ballet JJ; Couderc LJ; Rabian-Herzog C; Duval-Roy C; Janier M; Danon F; Clauvel JP; Seligmann M; Laboratoire d'Immunologie et d'Immunopathologie et, INSERM U108,; Hopital Saint-Louis, Paris, France.
T-cell mediated and humoral responses directed to microbial antigens were investigated, at the time of the initial visit, in a group of 139 patients with HIV-1-related persistent generalized lymphadenopathy (PGL) enrolled in a longitudinal study. In vivo and in vitro cell-mediated responses to tuberculin were lower in
Sjamsoedin-Visser LJ; Heijnen CJ; Zegers BJ; Stoop JW; Van Creveld Kliniek, Medisch Centrum Berg en Bosch, Bilthoven,; The Netherlands.
In human immune deficiency virus (HIV)-seropositive hemophilia patients, a low number of CD4 + lymphocytes is found, as well as a low CD4+/CD8+ ratio. In previous studies, it has been shown that antigen-specific T-helper cell (CD4+) function was present and no excessive antigen-specific T-suppressor cell (CD8+) functi
Allason-Jones E; Mindel A; Sargeaunt P; Katz D; Academic Department of Genito-Urinary Medicine, University; College, London.
Among homosexual men the prevalence of infection with Entamoeba histolytica is high. To determine the clinical importance of this infection 55 homosexual men carrying the parasite were investigated in detail. No clinical, serological, or histological evidence of invasive amoebiasis was found in any of them. The patien
James SP; Mucosal Immunity Section, National Institute of Allergy and; Infectious Diseases, Bethesda, Maryland.
A patient with an 18-yr history of Crohn s disease of the colon became infected with the human immunodeficiency virus. The patient had a complete remission of gastrointestinal symptoms in association with progressive immunodeficiency. This finding suggests that CD4 T cells and an intact immune response play a central
Schols D; Pauwels R; Vanlangendonck F; Balzarini J; De Clercq E; Rega Institute for Medical Research, University of Leuven,; Belgium.
Infection of human T4 lymphocyte MT-4 cells with human immunodeficiency virus (HIV) results in cell death 4-5 days after infection. We have now developed a highly sensitive and rapid procedure for estimating the cytopathic effect of HIV in MT-4 cells. This method is based on fluorometric as well as flow cytometric eva
Mizumoto K; Sugawara I; Ito W; Kodama T; Hayami M; Mori S; Division of Biochemical Genetics, Meiji Institute of Health; Science, Kanagawa, Japan.
We reported previously that homopolysaccharides with sulfate groups revealed immunomodulating activities--lymphocyte mitogens. We further investigated the role of homopolysaccharides in a different system--cultivation of Molt-4. clone no.8 with supernatant from human T cell lymphotropic virus type III (HTLV-III)-infec
Lancet. 1988 Nov 5;2(8619):1039-43. Unique Identifier : AIDSLINE MED/89038749
271 children born to HIV-infected mothers in 8 European centres are being followed up from birth in a multicentre, collaborative study. By June, 1988, 45% had been followed for over 1 year: 10 had developed AIDS or AIDS-related complex, all by the age of 9 months, of whom 5 had died. 22 other children had symptoms or
Lancet. 1988 Nov 5;2(8619):1043-6. Unique Identifier : AIDSLINE MED/89038750
486 children born to HIV-positive mothers, 57 children infected by blood products, and 1 child for whom the personal history was not available were studied. Perinatal infection had a more varied clinical picture and a worse outcome compared with infection acquired later in childhood. Severe secondary infections, neuro
Lancet. 1988 Nov 5;2(8619):1049-51. Unique Identifier : AIDSLINE MED/89038752
Smith DE; McLuckie A; Wyatt J; Gazzard B; Department of Medicine and Anaesthesiology, St Stephens Hospital,; London.
To find out whether Pneumocystis carinii pneumonia (PCP) can be detected while still in an early phase by the degree of exercise-induced oxygen desaturation, arterial oxygen saturation was measured by continuous pulse oximetry in patients positive for antibody to the human immunodeficiency virus and clinically suspect
Lancet. 1988 Nov 12;2(8620):1104-7. Unique Identifier : AIDSLINE MED/89038799
Decoster A; Darcy F; Caron A; Capron A; Laboratoire St Camille du Centre Hospitalier Feron-Vrau, St; Antoine, France.
Specific IgA antibodies against P30, a major surface protein of Toxoplasma gondii were sought in 198 serum samples (from 133 patients) by means of a double-sandwich enzyme-linked immunosorbent assay. These antibodies were detected in all cases of acute toxoplasmosis but in no cases of chronic toxoplasmosis nor in sero
Lancet. 1988 Nov 12;2(8620):1109-13. Unique Identifier : AIDSLINE MED/89038801
Matsuo H; Nakamura T; Tsujihata M; Kinoshita I; Satoh A; Tomita I; Shirabe S; Shibayama K; Nagataki S; First Department of Internal Medicine, Nagasaki University School; of Medicine, Japan.
In 11 of 18 patients with human T-lymphotropic virus type-I (HTLV-I) associated myelopathy (HAM) gait, sensory, and/or sphincter disturbance improved with plasmapheresis (4 to 6 sessions in 2 weeks), and the effects were maintained for 2 to 4 weeks. Plasmapheresis lowered the titre of HTLV-I antibody in serum but not
Epstein LG; Boucher CA; Morrison SH; Connor EM; Oleske JM; Lange JM; van der Noordaa J; Bakker M; Dekker J; Scherpbier H; et al; Virology Department, Academic Medical Center, Amsterdam, The; Netherlands.
In a longitudinal study, human immunodeficiency virus type 1 (HIV-1) antigen (HIV-Ag) was measured in serum specimens from 54 children with HIV-1 infection followed for a median duration of 17 months. The persistent detection of free HIV-Ag in a group of 25 children was associated with clinical deterioration in 22 (88
Wong JT; Department of Biochemistry, University of Toronto, Canada.
Covalent modification of hemoglobin and dextran-hemoglobin by reductive alkylation under aerobic conditions with periodated inositol tetrakisphosphate brought about a rightshifting of their oxygen dissociation curves. The rightshifted dextran-hemoglobin conjugate provided adequate oxygen delivery in macaques exchange-
Cancer Detect Prev. 1988;12(1-6):181-94. Unique Identifier : AIDSLINE MED/89028459
Dormont D; Yeramian P; Lambert P; Spire B; Daveloose D; Barre-Sinoussi FC; Chermann JC; Division de Radiobiologie et Radioprotection, Centre de; Recherches du Service de Sante des Armees, Clamart, France.
HPA23 is an antimonio-tungstate that exhibits numerous antiviral activities both in vivo and in vitro. It has been described as a competitive inhibitor of human immunodeficiency virus (HIV) reverse transcriptase (RT). Patients treated with daily injections of HPA23 show an inhibition of HIV RT activity in cell culture
Pauwels R; Balzarini J; Baba M; Snoeck R; Schols D; Herdewijn P; Desmyter J; De Clercq E; Department of Human Biology, Rega Institute for Medical Research,; Katholieke Universiteit Leuven, Belgium.
A rapid, sensitive and automated assay procedure was developed for the in vitro evaluation of anti-HIV agents. An HTLV-I transformed T4-cell line, MT-4, which was previously shown by Koyanagi et al. (1985) to be highly susceptible to, and permissive for, HIV infection, served as the target cell line. Inhibition of the
Burger H; Paul D; Siegal FP; Wendel I; Neff S; Eilbott D; Gehan K; Grimson R; Weiser B; Department of Medicine, State University of New York, Stony Brook; 11794.
We compared the Abbott enzyme immunoassay for human immunodeficiency virus (HIV) antigen with the reverse transcriptase assay (RTA) as a means of monitoring HIV infection during an antiviral trial. The Abbott enzyme immunoassay detected HIV earlier than RTA whether or not the patients were antigenemic and appears to b
Bagasra O; Lischner HW; Department of Microbiology, University of Medicine and Dentistry; of New Jersey-School of Osteopathic Medicine, Camden 08103-1505.
An enzyme immunoassay (EIA) for serum antibodies to human immunodeficiency virus type 1 (HIV-1), based on the synthetic pentadecapeptide SGKLICT-TAVPWNAS, a segment of the transmembrane glycoprotein (gp41) of the virus, was developed and tested for sensitivity and specificity. Sera of 152 individuals at various stages
Dowbenko D; Nakamura G; Fennie C; Shimasaki C; Riddle L; Harris R; Gregory T; Lasky L; Department of Molecular Immunology, Genentech, Inc., South San; Francisco, California 94080.
A soluble form of recombinant gp120 of human immunodeficiency virus type 1 was used as an immunogen for production of murine monoclonal antibodies. These monoclonal antibodies were characterized for their ability to block the interaction between gp120 and the acquired immunodeficiency syndrome virus receptor, CD4. Thr
Kodama T; Ohta Y; Masuda T; Ishikawa K; Tsujimoto H; Isahakia M; Hayami M; Department of Animal Pathology, University of Tokyo, Japan.
Mouse monoclonal antibodies were produced against simian immunodeficiency virus (SIV) from the African green monkey (SIVAGM). The antibodies reacted with the transmembrane protein of all five SIVAGM isolates but not with those of SIVs from the rhesus macaque and mandrill or of human immunodeficiency virus type 1 or ty
Galegov GA; Korneeva MN; Nosik DN; Kilesso TIu; Kraevskii AA
Action of three nucleoside analogues with azido-group on AIDS virus (human immunodeficiency virus--HIV) reproduction was studied in two cell species. Among these compounds there were 3 -azido-3 -deoxythymidine (Az-T), 3 -azido-3 -deoxyarabinothymidine (Az-AT) and 3 -azido-2 ,3 -dideoxy-5-methylcytidine (Az-dCMe). All
Price DB; Inglese CM; Jacobs J; Haller JO; Kramer J; Hotson GC; Loh JP; Schlusselberg D; Menez-Bautista R; Rose AL; et al; Department of Radiology, State University of New York Health; Science Center, Brooklyn.
A group of 23 pediatric patients seropositive for HIV antibody were studied by computed tomography and evaluated neurodevelopmentally. Significant neurodevelopmental delays were found in over 95% of the patients studied. CT findings in six patients were normal and thirteen of 23 (57%) had prominence of the CSF spaces.
Proc Natl Acad Sci U S A. 1988 Nov;85(21):7957-61. Unique Identifier : AIDSLINE MED/89042105
Michel ML; Mancini M; Sobczak E; Favier V; Guetard D; Bahraoui EM; Tiollais P; Unite de Recombinaison et Expression Genetique, Institut; National de la Sante et de la Recherche Medicale Unite 163,; Paris, France.
Fragments of the human immunodeficiency virus (HIV) envelope coding region have been fused with the hepatitis B virus envelope middle protein. In this system, HIV antigenic determinants are exposed at the surface of a highly antigenic structure, the hepatitis B surface antigen particle. Immunization of rabbits with th
Proc Natl Acad Sci U S A. 1988 Nov;85(22):8638-42. Unique Identifier : AIDSLINE MED/89042236
Koenig S; Earl P; Powell D; Pantaleo G; Merli S; Moss B; Fauci AS; Laboratory of Immunoregulation, National Institute of Allergy and; Infectious Diseases, Bethesda, MD 20892.
Freshly separated unfractionated peripheral blood mononuclear cells (PBMC) and cloned cell lines from a healthy human immunodeficiency virus 1 (HIV-1)-seropositive individual were examined for cytotoxic responses to HIV proteins expressed by recombinant vaccinia viruses. It was found that freshly isolated PBMC recogni
Schweiz Med Wochenschr. 1988 Nov 12;118(45):1651-6. Unique Identifier : AIDSLINE MED/89043879
Adam H; Flepp M; Schuler G; Egli F; Greminger P; Luthy R; Rhyner K; Departement fur Innere, Kantonalzurcherisches Krebsregister,; Universitatsspital Zurich.
Eleven patients with non-Hodgkin s lymphoma and three patients with Hodgkin s disease were observed among 876 anti-HIV-positive subjects attending the AIDS clinic at the University Hospital, Zurich, Switzerland . Compared to the general popu
Science. 1988 Nov 11;242(4880):919-22. Unique Identifier : AIDSLINE MED/89043969
Folks TM; Kessler SW; Orenstein JM; Justement JS; Jaffe ES; Fauci AS; Laboratory of Immunoregulation, National Institutes of Health,; Bethesda, MD 20892.
Myeloid progenitor cells were highly purified from normal human bone marrow by positive immunoselection with high-affinity monoclonal antibodies linked to magnetic beads and were successfully infected in vitro with the human immunodeficiency virus type 1 (HIV-1). From 99 to 100 percent pure bone marrow cells expressin
Science. 1988 Nov 25;242(4882):1168-71. Unique Identifier : AIDSLINE MED/89043988
Preston BD; Poiesz BJ; Loeb LA; Department of Pathology, University of Washington, Seattle 98195.
The human immunodeficiency virus type 1 (HIV-1) shows extensive genetic variation and undergoes rapid evolution. The fidelity of purified HIV-1 reverse transcriptase was measured during DNA polymerization in vitro by means of three different assays. Reverse transcriptase from HIV-1 introduced base-substitution errors
Science. 1988 Nov 25;242(4882):1171-3. Unique Identifier : AIDSLINE MED/89043989
Roberts JD; Bebenek K; Kunkel TA; Laboratory of Molecular Genetics, National Institute of; Environmental Health Sciences, Research Triangle Park, NC 27709.
A study was conducted to determine the fidelity of DNA synthesis catalyzed in vitro by the reverse transcriptase from a human immunodeficiency virus type 1 (HIV-1). Like other retroviral reverse transcriptases, the HIV-1 enzyme does not correct errors by exonucleolytic proofreading. Measurements with M13mp2-based fide
Hakansson C; Faergemann J; Lowhagen GB; Department of Dermatology, University of Goteborg, Sahlgrens'; Hospital, Sweden.
Pityrosporum ovale has been implicated in the pathogenesis of seborrheic dermatitis, a dermatosis occurring with high prevalence in symptomatic HIV-infected individuals. Quantitative cultures for P. ovale were taken in 12 HIV-seropositive patients and in 12 HIV-seronegative controls. Sera were analysed for antibodies
Sindrup JH; Weismann K; Sand Petersen C; Rindum J; Pedersen C; Mathiesen L; Worm AM; Kroon S; Sondergaard J; Lange Wantzin G; Department of Dermato-venerology, Bispebjerg Hospital, University; of Copenhagen, Denmark.
During a 6-month-period, 150 patients infected with Human Immunodeficiency Virus (HIV) were repeatedly examined by dermatologists and dentists for lesions of skin and oral mucosa. The most frequently encountered diseases were: oral hairy leukoplakia (21%), dermatophytosis (including tinea unguium/tinea pedis et inguin
Hodinka RL; Gilligan PH; Smiley ML; Clinical Microbiology-Immunology Laboratories, North Carolina; Memorial Hospital, Chapel Hill 27514.
The survival of human immunodeficiency virus (HIV) in three blood culture systems was examined. Cells of a continuous T-cell line (CEM) infected with HIV were inoculated into either Columbia or Middlebrook 7H12 broths, or a combination of an Isolator tube/Middlebrook broth. Virus viability studies were done by removin
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