ONCOGENES IN PEDIATRIC TUMORS

Important note: Information in this article was accurate in 1989. The state of the art may have changed since the publication date.

ONCOGENES IN PEDIATRIC TUMORS

Ettore Majorana Int Life Sci Ser; 4:1-265 1988. Unique Identifier : AIDSLINE ICDB/89657792
Anonymous; No affiliation given

Abstract: This volume contains the proceedings of a course held in 1986 at the International School of Medical Sciences, Ettore Majorana Centre for Scientific Culture, Erice (Trapani), Sicily, Italy. The emphasis is on the role of oncogenes in pediatric tumors and the techniques applied in these studies. The following topics are considered: the molecular approach to pediatric tumors; detection of N-myc oncogene mRNA in human neuroblastoma by in situ hybridization; genetic epidemiology of neuroblastoma and retinoblastoma and cellular oncogenes; Ha-ras proto-oncogene haplotypes and cancer risk; the use of Southern blot hybridization for the dissection of human leukocyte group A gene polymorphism and for analysis of class I and II genes in malignant melanoma; biological and molecular mechanisms of human T-lymphotropic virus (HTLV)-III superinfection of clones transformed by HTLV-I; transmission of HTLV-III infection in children; oncogenes in the immortalization and activation of macrophages; relationships between the expression of some proto-oncogenes in primary human neoplasia and cell cycle progression; drugs used in cancer therapy to induce cell differentiation of K562 in vitro and to change the transferrin receptor membrane expression and c-myc oncogene expression; biochemical characterization of DBL oncogene and its product; molecular analysis of the genes coding for hemopexin and ferritin; and analysis of oncogene translocation by in situ hybridization on chromosome preparations.

Keywords: Animal Child Cloning, Molecular *Gene Expression Regulation Human Neoplasms/*GENETICS *Oncogenes Proto-Oncogenes Translocation (Genetics) MONOGRAPH
891230
M89C0821

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