[THE LANGERHANS CELL] NLM AIDSLINE Important note: Information in this article was accurate in 1989. The state of the art may have changed since the publication date.

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[THE LANGERHANS CELL]

Colloq INSERM; 172:1-492 1988. Unique Identifier : AIDSLINE ICDB/89657989
Anonymous; No affiliation given

Abstract: The Langerhans cells are immunocompetent dendritic cells in the epidermis and the stratified epithelia. Proceedings of the Second Workshop on Langerhans Cells, held in Lyon, France, April 21-22, 1988, are presented. Recent developments in the following areas are discussed: origin and differentiation, surface antigens and cytoplasmic markers, immunopharmacology, in vitro antigen presentation, and Langerhans cells in cutaneous pathology. These cells represent a subpopulation of the mononuclear phagocyte system and play a great role in the induction of an immune response. They are able to catch exogenous antigens and present them to helper T lymphocytes, thus inducing T-cell proliferation. Langerhans cells also play a central role in presenting information to the lymphoid system about foreign antigens entering the body through the epithelia. In human pathology, Langerhans cells are involved in graft rejection, antitumoral inflammatory reactions, and in contact dermatitis as hypersensitivity reactions. Langerhans cells also express the membrane CD4 receptor for HIV and could be a potential virus reservoir.
Keywords: Acquired Immunodeficiency Syndrome/IMMUNOLOGY Animal Antigen-Presenting Cells/*IMMUNOLOGY Human HIV/IMMUNOLOGY Langerhans Cells/*IMMUNOLOGY Lymphocyte Transformation Neoplasms/IMMUNOLOGY T-Lymphocytes/*IMMUNOLOGY MONOGRAPHKWDacquiredimmunodeficiencysyndrome/immunologyanimalantigen-presentingcells/KWDimmunologyhumanhiv/immunologylangerhanscells/KWDimmunologylymphocytetransformationneoplasms/immunologyt-lymphocytes/KWDimmunologymonograph
891230
M89C0820

Copyright © 1989 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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