Antibodies to HTLV-1 in saliva of seropositive individuals from Japan. NLM AIDSLINE Important note: Information in this article was accurate in 1989. The state of the art may have changed since the publication date.

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Antibodies to HTLV-1 in saliva of seropositive individuals from Japan.

Viral Immunol. 1987-88;1(4):241-6. Unique Identifier : AIDSLINE MED/89374566
Archibald D; Essex M; McLane MF; Sauk J; Tachibana N; Mueller N; Department of Oral Pathology, Dental School, University of; Maryland, Baltimore.

Abstract: Secretory antibodies protect mucosal surfaces against transmission of many viruses. Human T-lymphotropic Virus, Type I (HTLV-I) is transmitted via blood products and via sexual contact across mucosal surfaces. We investigated the presence of HTLV-I-specific antibodies in whole saliva samples from 10 seronegative and 28 seropositive volunteers from a hospital in southern Japan. Antibodies directed to HTLV-I antigens were found in the salivas from 22 of 28 (79%) of the seropositive subjects. None of the seronegative individuals showed evidence of salivary antibodies. Antibodies directed to the envelope antigens of the virus were found in 21 of 22 positive saliva samples. Secretory antibodies may be important in preventing mucosal transmission.
Keywords: Adolescence Adult Aged Chromatography, Affinity Comparative Study Enzyme-Linked Immunosorbent Assay Female Human HIV Seropositivity/*IMMUNOLOGY HTLV-I Antibodies/*ANALYSIS HTLV-I Antigens/IMMUNOLOGY Japan Male Middle Age Saliva/*ANALYSIS/IMMUNOLOGY Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. Viral Envelope Proteins/*IMMUNOLOGY JOURNAL ARTICLEKWDadolescenceadultagedchromatography,affinitycomparativestudyenzyme-linkedimmunosorbentassayfemalehumanhivseropositivity/KWDimmunologyhtlv-iantibodies/KWDanalysishtlv-iantigens/immunologyjapanmalemiddleagesaliva/KWDanalysis/immunologysupport,non-uKWDsKWDgov'tsupport,uKWDsKWDgov't,pKWDhKWDsKWDviralenvelopeproteins/KWDimmunologyjournalarticle
891230
M89C0809

Copyright © 1989 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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