DNA probe reactivity of Mycobacterium avium complex isolates from patients without AIDS. NLM AIDSLINE Important note: Information in this article was accurate in 1989. The state of the art may have changed since the publication date.

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DNA probe reactivity of Mycobacterium avium complex isolates from patients without AIDS.

Diagn Microbiol Infect Dis. 1988 Nov;11(3):125-8. Unique Identifier : AIDSLINE MED/89231028
Drake TA; Herron RM Jr; Hindler JA; Berlin OG; Bruckner DA; Department of Pathology, UCLA School of Medicine 90024-1732.

Abstract: Mycobacterium avium complex isolates from 27 patients without AIDS and from 76 patients with AIDS were analyzed with the Gen-Probe Rapid Diagnostic System for Mycobacterium avium complex, and a retrospective chart review was performed to determine clinical significance of the isolates. While 87% of isolates from AIDS patients reacted only with the M. avium probe, only 37% from non-AIDS patients were M. avium probe positive (p less than 0.001). This pattern among non-AIDS patients was also observed among the 13 patients from whom isolates were considered to be clinically significant. Reactivity to both probes occurred with three isolates, two from non-AIDS patients that were not clinically significant and one from an AIDS patient. Results of further testing suggested that these represented dual infection with two coexisting strains. Awareness of the differences in DNA probe reactivity between isolates from AIDS and non-AIDS patients may influence testing strategies in the clinical laboratory.
Keywords: Acquired Immunodeficiency Syndrome/*COMPLICATIONS Cerebrospinal Fluid/MICROBIOLOGY Comparative Study *DNA Probes Human Lymph Nodes/MICROBIOLOGY Mycobacterium avium Complex/GENETICS/*ISOLATION & PURIF Mycobacterium avium-intracellulare Infection/COMPLICATIONS/ *MICROBIOLOGY Respiratory System/MICROBIOLOGY Retrospective Studies JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/KWDcomplicationscerebrospinalfluid/microbiologycomparativestudyKWDdnaprobeshumanlymphnodes/microbiologymycobacteriumaviumcomplex/genetics/KWDisolation&purifmycobacteriumavium-intracellulareinfection/complications/KWDmicrobiologyrespiratorysystem/microbiologyretrospectivestudiesjournalarticle
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M8980760

Copyright © 1989 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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