CLINICAL FEATURES AND STAGING OF KAPOSI'S SARCOMA

Important note: Information in this article was accurate in 1989. The state of the art may have changed since the publication date.

CLINICAL FEATURES AND STAGING OF KAPOSI'S SARCOMA

Kaposi's Sarcoma: Pathophysiology and Clinical Management. Ziegler JL, Dorfman RF, eds. New York, Marcel Dekker, p. 169-87, 1988.. Unique Identifier : AIDSLINE ICDB/89650415
Volberding PA; Sch. of Medicine, Univ. of California, San Francisco, CA

Abstract: The clinical presentation of Kaposi's sarcoma (KS) in patients (pts) with AIDS is reviewed and contrasted with the appearance of this tumor in other situations. In addition, the current status of staging systems for KS are discussed and recommendations are made for improving the staging of KS. Topics include: clinical pathological classification, histopathologic variants, clinical features in non-AIDS populations, KS in the iatrogenically immunosuppressed, clinical features of AIDS-related KS, oral KS, lymphatic involvement, visceral involvement, and associated lymphedema. Clinical features characteristic of KS in AIDS are: most common in homosexual AIDS pts; nodular, mixed cell tumors; widely disseminated in all body regions (especially face and oral cavity); visceral spread, common even early in disease course; severe underlying immune deficiency, with death from opportunistic infections; and incomplete and brief response to therapy. The most widely used staging system is the New York University system, which recognizes four stages: Stage I, cutaneous, locally indolent; Stage II, cutaneous, locally aggressive, with or without regional lymph nodes; Stage III, generalized mucocutaneous and/or lymph node involvement; and Stage IV, visceral. Despite its wide use, this staging system, like others, has several limitations; it is recommended that a staging system be developed and validated that separates pts as to tumor burden, systemic signs, and absolute number of T-helper cells. (51 Refs)

Keywords: Acquired Immunodeficiency Syndrome/COMPLICATIONS/PATHOLOGY Human Lymph Nodes/PATHOLOGY Lymphatic Metastasis Mouth Mucosa/PATHOLOGY Mouth Neoplasms/PATHOLOGY Neoplasm Staging Risk Factors Sarcoma, Kaposi's/CLASSIFICATION/*PATHOLOGY Skin/PATHOLOGY Skin Neoplasms/CLASSIFICATION/*PATHOLOGY MONOGRAPH REVIEW, TUTORIAL REVIEW

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M8940675

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