Washington, D.C. : Manisses Communications Group (1511 K St., N.W., Suite 314, Washington 20005), [c1987] iv, 67, A1-B4 p Unique Identifier : AIDSLINE CAT/8903592
Washington, DC : Bio-Data Publishers, c1988- v Unique Identifier : AIDSLINE CAT/8902419
Names, address, and telephone numbers of officials in the federal government; independent agencies, federal regions; state, county, and city governments; and international. Geographical arrangement.
A screening program was developed to systematically look for evidence of retroviral involvement in human hematopathologies and neurological disorders. Utilizing nucleic acid hybridization assays, fresh and cultured tissue samples from biopsy and autopsy were screened for DNA sequences complementary to characterized DN
Vaccines 88. New Chemical and Genetic Approaches to Vaccination: Prevention of AIDS and Other Viral, Bacterial, and Parasitic Diseases. Ginsberg H et al, eds. New York, Cold Spring Harbor Laboratory, p. 311-6, 1988.. Unique Identifier : AIDSLINE ICDB/89649774
Guy B; Kieny MP; Lecocq JP; Riviere Y; Montagnier L; Girard M; Transgene, 67082 Strasbourg Cedex, France
The genome of HIV, in addition to gag, pol, and env, codes at least five other proteins. The F (3 orf, orfB) gene encodes a 206-amino acid protein myristilated on its amino-terminal glycine. Biochemical properties of the mammalian and Escherichia coli recombinant F proteins were examined, and results are presented her
Vaccines 88. New Chemical and Genetic Approaches to Vaccination: Prevention of AIDS and Other Viral, Bacterial, and Parasitic Diseases. Ginsberg H et al, eds. New York, Cold Spring Harbor Laboratory, p. 335-9, 1988.. Unique Identifier : AIDSLINE ICDB/89649778
Norrby E; Chiodi F; Biberfeld G; Mufson MA; Parks E; Lerner RA; Dept. of Virology, Karolinska Inst., Stockholm, Sweden
Site-directed serology employing synthetic peptides is one means of improving the possibility of determining type-unique antibodies in a screening assay for HIV-1 or HIV-2. An enzyme-linked immunosorbent assay (ELISA) using such peptides has been developed that is specific for HIV-1. The test, designated the E32/E34 E
Kaposi's Sarcoma: Pathophysiology and Clinical Management. Ziegler JL, Dorfman RF, eds. New York, Marcel Dekker, 266 p., 1988.. Unique Identifier : AIDSLINE ICDB/89650408
Anonymous; No affiliation given
The etiology, pathophysiology, clinical features, and management of Kaposi s sarcoma (KS) are covered in the following chapters: history, epidemiology, and biomedical features of KS; pathology; histogenesis; role of cytomegalovirus in etiology; immunodeficiency; angiogenesis; clini
Kaposi's Sarcoma: Pathophysiology and Clinical Management. Ziegler JL, Dorfman RF, eds. New York, Marcel Dekker, p. 1-22, 1988.. Unique Identifier : AIDSLINE ICDB/89650409
Ziegler JL; Dorfman RF; Veterans Administration Medical Center, San Francisco, CA
The history, epidemiology, biologic features, and pathogenesis of Kaposi s sarcoma (KS) are reviewed and the implications for therapy are discussed. Topics include: classic KS, KS in Africa, KS and immunodeficiency, KS and AIDS, and the possible role of genetic factors, infectious agent(s), systemic influences, reticu
Kaposi's Sarcoma: Pathophysiology and Clinical Management. Ziegler JL, Dorfman RF, eds. New York, Marcel Dekker, p. 71-112, 1988.. Unique Identifier : AIDSLINE ICDB/89650411
Dorfman RF; Wood GS; Beckstead JH; Dept. of Pathology, Stanford Univ. Medical Center, Stanford, CA
Theories of the histogenesis of Kaposi s sarcoma (KS) are discussed based on morphologic observations at the light microscopic and electron microscopic levels, enzyme histochemical studies, immunohistochemical studies, and experimental methods (tissue culture and reproduction of the disease in animal systems). The var
Kaposi's Sarcoma: Pathophysiology and Clinical Management. Ziegler JL, Dorfman RF, eds. New York, Marcel Dekker, p. 113-28, 1988.. Unique Identifier : AIDSLINE ICDB/89650412
Drew WL; Huang ES; Clinical Microbiology and Infectious Diseases, Mount Zion Hosp.; and Medical Center, San Francisco, CA
Evidence linking cytomegalovirus ( CMV ) to the etiology of Kaposi s sarcoma (KS) is reviewed, including the oncogenic potential of human CMV in vitro, epidemiologic evidence (CMV in renal transplant patients, homosexual men, a
Kaposi's Sarcoma: Pathophysiology and Clinical Management. Ziegler JL, Dorfman RF, eds. New York, Marcel Dekker, p. 151-68, 1988.. Unique Identifier : AIDSLINE ICDB/89650414
Ziegler JL; Veterans Administration Medical Center, San Francisco, CA
Evidence supporting a link between angiogenesis and the development of Kaposi s sarcoma (KS) is presented under the following headings: oncogenes, the endothelial cell, angiogenic factors (eg, tumor angiogenesis factor, leukemia growth factor, macrophage growth factor, glial growth factor, and endothelial cell growth
Kaposi's Sarcoma: Pathophysiology and Clinical Management. Ziegler JL, Dorfman RF, eds. New York, Marcel Dekker, p. 169-87, 1988.. Unique Identifier : AIDSLINE ICDB/89650415
Volberding PA; Sch. of Medicine, Univ. of California, San Francisco, CA
The clinical presentation of Kaposi s sarcoma (KS) in patients (pts) with AIDS is reviewed and contrasted with the appearance of this tumor in other situations. In addition, the current status of staging systems for KS are discussed and recommendations are made for improving the staging of KS. Topics include: clinical
Kaposi's Sarcoma: Pathophysiology and Clinical Management. Ziegler JL, Dorfman RF, eds. New York, Marcel Dekker, p. 189-235, 1988.. Unique Identifier : AIDSLINE ICDB/89650416
Wall SD; Dept. of Radiology, Veterans Administration Medical Center, San; Francisco, CA
The utility and application of imaging techniques used in the diagnosis of AIDS-associated Kaposi s sarcoma (KS) in the abdomen, chest, and head are discussed. Angiography, lymphangiography, and plain films of the skeleton, traditionally employed in evaluation of patients (pts) with KS, are not useful in AIDS-associat
Kaposi's Sarcoma: Pathophysiology and Clinical Management. Ziegler JL, Dorfman RF, eds. New York, Marcel Dekker, p. 249-59, 1988.. Unique Identifier : AIDSLINE ICDB/89650418
Volberding PA; Sch. of Medicine, Univ. of California, San Francisco, CA
The background of chemotherapy in non-AIDS-related Kaposi s sarcoma (KS) is summarized, agents that have been used in patients (pts) with AIDS are discussed, and management guidelines are offered. The following therapeutic agents are discussed: vinblastine, vincristine, etoposide (VP-16), alternating vinblastine and v
Dev Med Virol; 4:1-366 1988. Unique Identifier : AIDSLINE ICDB/89649846
Anonymous; No affiliation given
Clinical applications of interferons (IFNs) in infectious and immune diseases, clinical applications of IFNs in cancer, and biological properties of IFNs as shown by experimental systems are reviewed. The following topics are covered: intranasal IFNs for control of respiratory viral infections; IFN therapy of herpes s
Dev Med Virol; 4:62-74 1988. Unique Identifier : AIDSLINE ICDB/89649847
Krown SE; Memorial Sloan-Kettering Cancer Center, 1275 York Ave., New York,; NY 10021
The role of interferons (IFNs) in the treatment of Kaposi s sarcoma (KS) is reviewed and the potential role of IFNs in the treatment of opportunistic infections associated with AIDS is discussed. Results of the author s initial trial, in which 5/12 patients (pts) with AIDS-associated KS responded to daily im doses of
Dev Med Virol; 4:353-63 1988. Unique Identifier : AIDSLINE ICDB/89649867
Feinman R; Vilcek J; Dept. of Microbiology, New York Univ. Medical Center, 550 First; Ave., New York, NY 10016
Cytotoxic/cytostatic and antitumor actions of tumor necrosis factor (TNF), synergistic enhancement of tumor cell cytotoxicity with TNF and interferons (IFNs), and synergistic antitumor actions of TNF and IFNs are reviewed. Although TNF and lymphotoxin (LT) are known to be directly cytostatic or cytotoxic for tumor cel
Inglis AD; Medrano ML; Seton Medical Center, Austin, Texas.
To date in the United States , 41,366 cases of acquired immunodeficiency syndrome (AIDS) have been reported, constituting a major health disaster. As AIDS spreads to the heterosexual population, perinatal hospital areas are seeing increasing numbers of AIDS patients and their families.
Can J Anaesth. 1988 Nov;35(6):655-65. Unique Identifier : AIDSLINE MED/89077679
Browne RA; Chernesky MA; Department of Anaesthesia, Faculty of Health Sciences, McMaster; University, Hamilton, Ontario.
The methods of dealing with various items of anaesthetic equipment in order to assure a fresh supply for each patient have been discussed. These consist of using disposable items, steam sterilization, disinfection by both chemical methods and pasteurization and the use of ethylene oxide sterilization. The use of dispo
Lambertus MW; Mathisen GE; Sepulveda Veterans Administration Medical Center, Los Angeles,; California.
We report a case of aquarium-borne Mycobacterium marinum infection in a patient who presented simultaneously with cryptosporidiosis and the acquired immunodeficiency syndrome.
Veres Z; Neszmelyi A; Szabolcs A; Denes G; Central Research Institute for Chemistry, Hungarian Academy of; Sciences, Budapest.
Some 3 - and/or 5 -substituted pyrimidine nucleosides, as well as anhydropyrimidine nucleosides, which have no flexibility about the N-glycosidic bond were studied as inhibitors of thymidine phosphorylase and uridine phosphorylase. The conformation of some analogs was also investigated in order to obtain information o
Massari V; Brunet JB; Bouvet E; Valleron AJ; Unite de Recherches Biomathematiques et Biostatistiques (URBB); INSERM, Universite Paris 7, France.
A study was conducted by the French Communicable Diseases Network to evaluate the use of HIV-antibody testing by general practitioners. The study was aimed at determining the type of patient being tested and why. Data from two periods, Nov-Dec 86 and March-April 87, were compared. The percentages of subjects spontaneo
Gen Hosp Psychiatry. 1988 Nov;10(6):423-30. Unique Identifier : AIDSLINE MED/89078958
Karlinsky H; Taerk G; Schwartz K; Ennis J; Rodin G; Department of Psychiatry, Toronto General Hospital, University of; Toronto, Ontario, Canada.
The conventional psychiatric opinion that suicide is a manifestation of psychiatric illness may not apply to circumstances in which suicide or the refusal of life-sustaining medical treatment results from the rational decisions of autonomous individuals. As medical technology advances, questions about the prolongation
Guinness LF; Sibandze S; McGrath E; Cornelis AL; Department of Obstetrics and Gynaecology, Mbabane Government; Hospital, Swaziland.
In a survey of 283 deliveries in Swaziland , active syphilis (positive results in the Treponema pallidum haemagglutination assay (TPHA) and the rapid plasma reagin (RPR) test) was found in 37 (13.1%) and possibly active infection (positive TPHA but negative RPR test results) in a
van Griensven GJ; de Vroome EM; Tielman RA; Coutinho RA; Department of Public Health and Environment, Municipal Health; Service, Amsterdam, The Netherlands.
Two hundred and seventy seven homosexual men participating in an AIDS study in Amsterdam, The Netherlands , were interviewed in July to December 1986 regarding their experiences with the use of condoms during anogenital intercourse. It appeared that in many cases the condoms us
Volberding PA; University of California, San Francisco.
Caring for patients with AIDS poses new and serious challenges for the medical care system, particularly the hospital. Stresses associated with the care of AIDS patients are generated by the medical complexities of the disease, by the stigma attached to the disease and the patients affected, and by the often overwhelm
Obata S; Matsuzaki H; Nishimura H; Kawakita M; Takatsuki K; Second Department of Internal Medicine, Kumamoto University; Medical School.
Gastroduodenal endoscopic examinations were performed on 15 patients with adult T-cell leukemia (ATL). Twelve had the disease in acute form, two in chronic form and one patient was in crisis. Eight patients had gastroduodenal lesions, four esophageal candidiasis, three gastric infiltration and two duodenal ATL-cell in
Med Educ. 1988 Sep;22(5):418-25. Unique Identifier : AIDSLINE MED/89082378
Vollmer SA; Wells KB; UCLA School of Medicine.
The authors assessed the expected degree of comfort among first-year students at two California medical schools in taking a sexual history from four types of patients: heterosexual men; heterosexual women; homosexual (men and women combined); and an AIDS patient. Data were from questionnaires administered at two Calif
Med Hypotheses. 1988 Sep;27(1):1-4. Unique Identifier : AIDSLINE MED/89082386
Dominy SS
It is proposed that peptide T, a protein sequence found in the HIV coat, shares homology with the carboxyl-terminal extension of the gamma-3-MSH neuropeptide. Based on this observation, it is hypothesized that the N-terminal gamma-MSH sequence is probably present in the glycoprotein coat. It is concluded that many of
Med Hypotheses. 1988 Sep;27(1):51-4. Unique Identifier : AIDSLINE MED/89082395
Hebert JR; Barone J; Division of Epidemiology, American Health Foundation, New York,; NY 10017.
It is noted that host resistance or susceptibility factors are important in determining the probability of contracting many diseases. Though AIDS has been studied primarily in terms of exposure to disease agents, it is proposed that factors affecting susceptibility or resistance be considered. Because of its effect on
Med Hypotheses. 1988 Sep;27(1):81-2. Unique Identifier : AIDSLINE MED/89082401
Yabrov A; Bureau of Biological Research, Rutgers, State University of New; Jersey, Piscataway 08854.
A new approach for treatment of AIDS is suggested. This is to isolate the patient s blood, to remove anti-T-cell substance from the plasma, and treat the cells with an anti-viral agent. And then return it into the patient.
N Z Med J. 1988 Dec 14;101(859):809-13. Unique Identifier : AIDSLINE MED/89083031
Paul C; Skegg DC; Smeijers J; Spears GF; Department of Preventive and Social Medicine, University of Otago; Medical School, Dunedin.
A survey of contraceptive practice in New Zealand was carried out using a population-based sample of women, aged 25 to 54, selected as control subjects in a national case-control study. The results showed that sterilisation has become the most common means of family limitation.
Recent Results Cancer Res. 1988;112:84-92. Unique Identifier : AIDSLINE MED/89084093
Christ H; Department of Social Work, Memorial Sloan-Kettering Cancer; Center, New York, NY 10021.
The social, psychological, and ethical challenge of AIDS, specifically AIDS-related cancers, is as complex as the biological and medical. Both the patient and his or her sexual partner experience a number of stresses to which they must adapt. AIDS also poses a challenge to professionals and to the social fabric of cou
Bender BS; Davidson BL; Kline R; Brown C; Quinn TC; Division of Infectious Diseases, University of Florida College of; Medicine, Gainesville.
In studies aimed at defining monocyte and macrophage function in patients with human immunodeficiency virus (HIV) infection, we found impaired in vivo Fc receptor-specific clearance in 20 of 25 patients with acquired immunodeficiency syndrome (AIDS) and in five of 13 patients with AIDS-related illnesses. The in vivo f
Torres-Anjel MJ; Volz D; Torres MJ; Turk M; Tshikuka JG; Department of Veterinary Microbiology, University of Missouri,; Columbia 65211.
Studies of rabies virus in several animal models consistently showed hypothalamic infection, hypophyseal infection, dramatic growth impairment (in the form of failure to thrive), wasting syndrome, and immune depletion. Rabies virus infection was studied through routine monoclonal antinucleocapsid antibody immunofluore
Schweiz Med Wochenschr. 1988 Nov 26;118(47):1762-6. Unique Identifier : AIDSLINE MED/89084548
Hungerbuhler U; Kulstrunk M; Osusky R; Medizinische Universitats-Poliklinik, Departement fur Innere; Medizin, Universitatsspital Basel.
We report on a 33-year-old male Turkish patient with primarily nonsuspect sexual behavior who presented with panuveitis unresponsive to therapy. HIV infection and secondary syphilis was diagnosed. The uveitis was the only manifestation of syphilis. Because of isosporiasis ,
Ross MW; STD Services, South Australian Health Commission, Adelaide.
Knowledge of, and attitudes toward, AIDS were assessed in a random sample of over 2600 individuals aged 16 and over in all states and territories of Australia . Those with lower knowledge of AIDS were more likely to be separated, divorced or widowed, older, and more personally co
Z Gastroenterol. 1988 Jun;26(6):293-6. Unique Identifier : AIDSLINE MED/89085766
Riemann JF; Kohler B; Medizinische Klinik C, Klinikum der Stadt Ludwigshafen am Rhein.
Endoscopy has not remained unaffected by the increasing number of AIDS patients. A survey among German gastroenterologic centers has shown that most endoscopists pay close attention to this problem. It may be true that the safety precautions, considered to be necessary by some if a patient s HIV status is unknown, are
Ann N Y Acad Sci. 1988;540:624-7. Unique Identifier : AIDSLINE MED/89086977
Andersson M; Bergstrom T; Blomstrand C; Hermodsson S; Hakansson C; Lowhagen GB; Department of Neurology, University of Gothenburg, Sahlgren's; Hospital, Sweden.
Ann N Y Acad Sci. 1988;540:628-9. Unique Identifier : AIDSLINE MED/89086978
Lyman WD; Kress Y; Rashbaum WK; Calvelli TA; Steinhauer E; Kashkin JM; Henderson CE; Rubinstein A; Albert Einstein College of Medicine, Bronx, New York 10461.
Ann Neurol. 1988 Dec;24(6):727-31. Unique Identifier : AIDSLINE MED/89087114
Grimaldi LM; Roos RP; Devare SG; Casey JM; Maruo Y; Hamada T; Tashiro K; University of Chicago, Department of Neurology, IL 60637.
Human T-cell lymphotropic virus type I (HTLV-I)-associated myelopathy (HAM) and tropical spastic paraparesis belong to a new group of neurological diseases associated with retroviral infection. An HTLV-I-like virus has recently been implicated in multiple sclerosis as well. We studied paired cerebrospinal fluid and se
Biochem Biophys Res Commun. 1988 Dec 30;157(3):1369-75. Unique Identifier : AIDSLINE MED/89087463
Munch-Petersen B; Institute of Life Sciences & Chemistry, Roskilde University,; Denmark.
Until now, 3 -Azido-3 -deoxythymidine ( AZT ) is the most widely used drug in AIDS therapy, but the positive anti HIV effect of the drug is often accompanied by severe side effects such as bone-marrow suppression. In the present study, the effect of AZT
HTLV-IIIB-infected H9 cells are shown to contain a high level of the natural UAG suppressor glutamine tRNA(UmUG Gln); this tRNA has been demonstrated to be required for the synthesis of Moloney murine leukemia virus (Mo-MuLV)-encoded protease. After cultivation of HTLV-IIIB-infected H9 cells with Avarol at a concentra
AIDS Res Hum Retroviruses. 1988 Aug;4(4):295-304. Unique Identifier : AIDSLINE MED/89087768
Alvord WG; Drummond JE; Arthur LO; Biggar RJ; Goedert JJ; Levine PH; Murphy EL Jr; Weiss SH; Blattner WA; Data Management Services, National Cancer Institute-Frederick; Cancer Research Facility, MD 21701.
Latent structure analysis can be used to determine sensitivity and specificity rates of human immunodeficiency virus antibody assays in the absence of previous clinical or laboratory results. The technique was applied to the analysis of data obtained when a panel of serum samples, collected as part of a large-scale sc
Tajima K; Biological Informatics Section, International Institute for; Advanced Study of Social Information Science, Tokyo, Japan.
This paper describes a multiple alignment method using a workstation and supercomputer. The method is based on the alignment of a set of aligned sequences with the new sequence, and uses a recursive procedure of such alignment. The alignment is executed in a reasonable computation time on diverse levels from a worksta
Weisberg LA; Greenberg J; Stazio A; Department of Neurology and Psychiatry, Tulane Medical Center,; New Orleans, LA 70112.
The clinical and computerized tomographic (CT) findings in 10 patients with cerebral toxoplasmosis are reviewed. All patients with cerebral toxoplasmosis were homosexuals and/or intravenous drug users, and all patients had other manifestations of AIDS. Two presented with focal seizures, 4 presented with focal neurolog
Bottiger B; Ljunggren K; Karlsson A; Krohn K; Fenyo EM; Jondal M; Biberfeld G; Department of Immunology, National Bacteriological Laboratory,; Stockholm, Sweden.
The presence of neutralizing antibodies against human immunodeficiency virus type 1 (HIV-1) was investigated in sera from 73 HIV-1 seropositive subjects at different clinical stages. Virus neutralization was measured as survival of MT-4 cells in a 6-7 day microassay. Sixty-three sera were also tested for antibodies in
Ljunggren K; Broliden PA; Morfeldt-Manson L; Jondal M; Wahren B; Department of Immunology, Karolinska Institute, Stockholm,; Sweden.
The anti-HIV IgG subclass response was analysed in sera from different clinical stages and related to virus specific antibody-dependent cellular cytotoxicity (ADCC). IgG1 was found to be the dominant subclass, present in all sera and with similar mean titres at different stages. The number of anti-HIV IgG3 positive se
Chung Hua Min Kuo Wei Sheng Wu Chi Mien I Hsueh Tsa Chih. 1988 Feb;21(1):50-9. Unique Identifier : AIDSLINE MED/89090637
Wang GR; Department of Internal Medicine, TCollege of Medicine, National; Taiwan University, Taipei, ROC.
A total of 26,210 serum samples from 16 acquired immunodeficiency syndrome (AIDS) risk groups were tested for human immunodeficiency virus (HIV) antibody, using mainly enzyme-linked immunosorbent assay (ELISA) and Western blot. Among 751 homosexuals, 15 were positive (2.0%): 3 were full-blown AIDS patients; 2, AIDS-re
Ebbesen P; Melbye M; Suni J; Krueger GR; Fust G; Nagy K; Horvath A; Ujhelyi E; Briem H; Aiuti F; et al; Danish Cancer Society, Department of Virus and Cancer, Aarhus.
The ECP Working Group on AIDS has evaluated the available data on seropositivity to HIV-1 supplied by research groups in 12 Eastern and Western European countries. The period covered is 1985 and 1986. A significantly elevated incidence of seropositives was observed in both females and males in heterosexual contact wit
Mantovani G; Piso A; Santa Cruz G; Arangino V; Farci G; Leone AL; Orru S; Coiana A; Massidda A; Zucca G; et al; Department of Internal Medicine, University of Cagliari, Italy.
Two familial cases of hairy cell leukaemia are reported: a daughter, 44-years-old, with a very unusual ultrastructural pattern found in hairy cells, the tubuloreticular inclusions, and her mother, 71-years-old, who was affected six years later. Routine laboratory investigations, cytochemical and cytogenetic studies in
Among 9867 sera tested between January and April 1987 by Abbott HTLV-III EIA (cell culture-derived antigen) 155 reacted repeatedly positive. 22% of these could not be confirmed, while 77% could be confirmed by other tests. The results of 2 sera remained equivocal. Subsequently Abbott recombinant HTLV-III EIA was used
Tassoni A; Cavazza S; Toderini G; Hopital Maggiore C.A. Pizzardi, Bologna, Italia.
We examined 42 patients with the acquired immune deficiency syndrome: 11 of these had retinal lesions. In this study we reported five cases; all were examined within several weeks of admission to the Maggiore Hospital, and at various intervals thereafter. Ophthalmic evaluation included determination of visual acuity,
J Med Virol. 1988 Dec;26(4):339-51. Unique Identifier : AIDSLINE MED/89094288
Asher DM; Goudsmit J; Pomeroy KL; Garruto RM; Bakker M; Ono SG; Elliot N; Harris K; Askins H; Eldadah Z; et al; Laboratory of Central Nervous System Studies, National Institute; of Neurological and Communicative Disorders and Stroke, Bethesda,; MD 20892.
Sera collected from 1,102 individuals in 14 populations of the southwestern Pacific between 1956 and 1979 were tested by ELISA for antibodies to human T-cell leukemia virus type I (HTLV-I). Selected sera were also tested by particle agglutination and immunoblotting. Six of the populations had prevalences of antibodies
Chiodi F; Sonnerborg A; Albert J; Gaines H; Norkrans G; Hagberg L; Asjo B; Strannegard O; Fenyo EM; Department of Virology, Karolinska Institute, Stockholm, Sweden.
Isolation of the human immunodeficiency virus (HIV) has been attempted from the cerebrospinal fluid (CSF) of 29 subjects with varying severity of HIV infection. Virus could be isolated from patients in all stages of disease including patients with primary HIV infection and asymptomatic carriers. In the early stages of
Kira J; Minato S; Itoyama Y; Goto I; Kato M; Hasuo K; Department of Neurology, Faculty of Medicine, Kyushu University,; Fukuoka, Japan.
Magnetic resonance imaging (MRI) of the brain and electroencephalography (EEG) were carried out for patients with human T-lymphotropic virus type I (HTLV-I)-associated myelopathy (HAM). Nineteen of 22 patients (86%) had abnormalities on brain MRI and/or EEG. Thirteen patients showed high signal intensity lesions scatt
Minato S; Itoyama Y; Goto I; Yamamoto N; Department of Neurology, Kyushu University, Fukuoka, Japan.
The HTLV-I antigen (Ag) was detected in short-term cultured peripheral blood mononuclear cells (PBMNC) from 44% of patients with HTLV-I-associated myelopathy (HAM), using the indirect immunofluorescence method. The HTLV-I Ag-positive cells accounted for less than 4% of cultured PBMNC in all but one case. The kinetics
Bayik MM; Badur S; Kalayci C; Basaran S; Marmara University, School of Medicine, Istanbul, Turkey.
Acquired immunodeficiency syndrome (AIDS) can be transmitted through heterosexual intercourse and prostitutes may be responsible for this form of transmission. Thirty-four prostitutes were included in this study and their humoral and cellular immunological parameters were compared with control group. Prostitutes were
A 29-year-old woman with HIV-infection developed disseminated abscesses of the skin, identified as an infection with Actinomyces israelii. To our knowledge, actinomycosis associated with HIV-infection (AIDS-related complex) has been reported only once previously.
Our own results in dermatology are highlighted, such as the oral hairy leukoplakia associated with AIDS, treatment with Acyclovir for herpetic infections, laser therapy for angiomas, Lyme disease, x-ray therapy in Kaposi s sarcomas, photosensitivity reactions by treatment with t
Basing on the actual publications, the most important neurological and psychopathological symptoms of HIV-infection are systematically reported. Opportunistic infections are producing important neurological symptoms. A case of Cryptococcus neoformans-Infection of the brain is described.
Adams A; Egan A; Department of Nursing, Montefiore Medical Center, Bronx, NY; 10467.
Concern about the spread of infections in the hospital setting has prompted regulatory agencies to mandate infection control standards. Each hospital department is required to have written policies and procedures which describe measures to prevent and control the spread of nosocomial infections (hospital acquired infe
Vinters HV; Mah V; Mohrmann R; Wiley CA; Department of Pathology (Neuropathology), UCLA Medical Center; 90024-1732.
A young female patient with a long history of intravenous drug abuse died after a fulminant course of aplastic anemia. At postmortem examination, she was found to have multinucleate giant cells and immunocytochemical evidence of human immunodeficiency virus (HIV) infection of the central nervous system. This case rais
Dianzani F; Antonelli G; Capobianchi MR; De Marco F; Institute of Virology, University of Rome, Italy.
Replication kinetics of HIV was studied under single growth cycle conditions by backtitrating infectious virus released or remained cell-associated at each time point. Under these conditions HIV seems to replicate faster than previously estimated. The amount of cell-associated virus always exceeds the one detectable i
Lovati MR; Manzoni C; Mosconi C; Colli S; Sirtori CR; Fumagalli G; Clementi F; Department of Pharmacology, University of Milan, Italy.
The Ivanovas-Sieve (IVA-SIV) rat represents the only available animal model of endogenous hypertriglyceridemia, in the absence of obesity and/or overt diabetes. Since plasma lipids/lipoproteins can modulate platelet reactivity and eicosanoid metabolism, these were examined in two groups of Charles River (CR) and IVA-S
Fling JA; Fischer JR Jr; Boswell RN; Reid MJ; Department of Medicine, Wilford Hall United States Air Force; Medical Center, Lackland Air Force Base, Texas 78236.
Serum immunoglobulins were measured in 107 patients with human immunodeficiency virus seropositivity. Each patient was categorized by the Walter Reed staging classification and serum concentrations of immunoglobulins were compared with patient staging. Serum IgM concentrations were normal in all but nine patients. Ser
Up to 31 December 1987, 1227 cases meeting the World Health Organization Centers for Disease Control (U.S.A.) (WHO/CDC) definition of the acquired immune deficiency syndrome (AIDS) were reported in the U.K., of which 54 were in persons who came to the U.K. for diagnosis and treatment a
Moriyama K; Muranishi H; Nishimura J; Tanaka K; Asayama R; Takita A; Department of Internal Medicine, Hamanomachi General Hospital,; Fukuoka.
We treated two Japanese patients with Pneumocystis carinii pneumonia. Inclusion bodies in both adrenal glands of patient no. 1 indicated a herpesvirus infection. The patient no. 2 recovered from the pneumonia upon sulfametoxazole-trimethoprim medication and high-dose methylprednisolone therapy. In both patients, anti-
Wolff H; Anderson DJ; Department of Obstetrics, Gynecology and Reproductive Biology,; Brigham and Women's Hospital, Harvard Medical School, Boston,; Massachusetts.
In this study we investigated whether elevated levels of the inflammatory mediator granulocyte elastase in seminal plasma were associated with increased numbers of CD4+ T helper/inducer lymphocytes and monocytes/macrophages in semen, the principal host cells of the human immunodeficiency virus (HIV). Semen samples wer
Screening of antibodies to structural and nonstructural gag gene-coded proteins in humans with lymphadenopathy and AIDS was performed by means of radioimmunoprecipitation (RIP) and western blotting. Pr78gag precursor of gag-coded proteins of type-D retrovirus from Hep-2 cells served as an antigen in RIP tests. Total n
Schmid I; Schmid P; Giorgi JV; Department of Microbiology, UCLA School of Medicine 90024.
We describe a simple, reproducible, and generally applicable method to assess the performance of log amplifiers by using a fluorescent sample that provides multiple peaks of different intensities. The channel differences between multiple peaks are used to evaluate the logarithmic behavior of the fluorescence signal am
Int J Epidemiol. 1988 Sep;17(3):625-8. Unique Identifier : AIDSLINE MED/89092610
Ishida T; Yamamoto K; Omoto K; Department of Anthropology, Faculty of Science, University of; Tokyo, Japan.
The prevalence of human T-lymphotropic retrovirus type-1 (HTLV-1) was examined in the Asian Pacific area to search for endemic foci outside Japan . A total of 1323 sera from healthy subjects in the Philippines including Filipino lowlanders, M
A fragment of HTLV-IIIB gag-gene, coding for the first 441 amino acids of the p53 gag-precursor was expressed in the recombinant vaccinia virus, vC5. Two HIV specific proteins were detected by western blot in CV-1 cells infected with vC5. Their relative molecular masses were 50 and 35 Kd, pointing out that the first o
Am J Drug Alcohol Abuse. 1988;14(1):29-39. Unique Identifier : AIDSLINE MED/89103233
Lange WR; Haertzen CA; Hickey JE; Snyder FR; Dax EM; Jaffe JH; Addiction Research Center, National Institute on Drug Abuse,; Baltimore, Maryland 21224.
Nitrite inhalants, as drugs of abuse, have received a new prominence in the literature since their use has been associated with Kaposi s Sarcoma and possibly other manifestations of acquired immunodeficiency syndrome (AIDS). Changes in patterns and prevalence of use have not been investigated since the onset of the AI
Goudsmit J; Ljunggren K; Smit L; Jondal M; Fenyo EM; Jonda M/[corrected to Jondal M]; Virology Department, University of Amsterdam, The Netherlands.
Human antibodies to HIV antigens expressed on the surface of infected cells may inhibit cell fusion with uninfected CD 4-positive cells and mediate killing of the infected cells by effector cells bearing the Fc receptor. Sequential sera from ten HIV-antibody seroconverted men, of which five progressed to ARC or AIDS (
Jackson JB; Balfour HH Jr; Department of Laboratory Medicine and Pathology, University of; Minnesota Medical School, Minneapolis 55455.
Since the discovery of human immunodeficiency virus (HIV) as the causative agent of acquired immunodeficiency syndrome in 1983, there has been a proliferation of diagnostic tests. These assays can be used to detect the presence of HIV antibody, HIV antigen, HIV ribonucleic and deoxyribonucleic acids, and HIV reverse t
Cell. 1988 Dec 23;55(6):1159-69. Unique Identifier : AIDSLINE MED/89077544
Wilson W; Braddock M; Adams SE; Rathjen PD; Kingsman SM; Kingsman AJ; Department of Biochemistry, University of Oxford, England.
The pol gene of the human immunodeficiency virus (HIV-1) is expressed as a gag:pol fusion, arising from a ribosomal frameshift that brings the overlapping, out-of-phase gag and pol genes into translational phase. In this study, we show that HIV frameshifting is mediated by a very short sequence in the viral RNA. We de
Jaffe HW; Lifson AR; AIDS Program, Centers for Disease Control, Atlanta, Georgia.
Transmission of HIV can occur during sexual contact, through parenteral exposure to blood and blood products, and from mother to child during the perinatal period. The possibility that some previously unrecognized route of HIV transmission might exist or could occur in the future can never be entirely excluded. For th
Wofsy CB; Department of Medicine, University of California, San Francisco.
With screening of the blood supply and effective heat and chemical treatment of blood product derivatives, the overwhelming majority of newly acquired adult HIV infections will result from consensual acts, through the exchange of blood or sexual secretions. Societal relaxation about discussion of sex, death, homosexua
Gerberding JL; Department of Medicine, University of California, San Francisco.
The perception that HIV is a highly contagious nosocomial pathogen persists despite a great deal of evidence to the contrary. However, health care workers are at a low but finite risk of occupational infection with the virus, particularly through accidental needle-stick inoculations with infected blood. Universal bloo
Tindall B; Cooper DA; Donovan B; Penny R; Centre for Immunology, St Vincent's Hospital, Sydney, Australia.
The identification of characteristic clinical, serologic, and immunologic responses to primary HIV infection has contributed greatly to our understanding of the natural history of HIV infection. Subjects usually present with a mononucleosis-like illness and during the period of primary infection there is a characteris
Abrams DI; Department of Medicine, University of California, San Francisco.
With the passage of time and the refinement of laboratory techniques, the ability to recognize disease related to human immunodeficiency virus infection has improved. Currently, a number of clinical conditions can be identified as pre-AIDS syndromes. These include the syndrome of persistent generalized lymphadenopathy
Hollander H; Department of Medicine, University of California, San Francisco.
There are few comprehensive guidelines for the evaluation of individuals with known or suspected human immunodeficiency virus (HIV) infection. Despite the availability of high technology diagnostic testing, routine history taking and physical examination play an important role in the estimation of likelihood of prior
Greenspan JS; Greenspan D; Winkler JR; Division of Oral Biology, School of Dentistry, University of; California, San Francisco.
The oral manifestations of HIV infection present as a variety of opportunistic infections, neoplasms, and other lesions. Some of these are common, perhaps the most common, features of HIV disease and are highly predictive of the development of AIDS. Clinicians caring for HIV-infected persons should become familiar wit
Cello JP; University of California, San Francisco.
Gastrointestinal symptoms are pervasive in patients with AIDS. Organ-specific symptoms, particularly dysphagia, postprandial emesis, hematemesis, biliary colic, increasing abdominal girth, and small volume diarrhea, are usually easy to diagnose definitively and may respond to specific therapy. Thorough invasive and no
Hopewell PC; University of California, San Francisco.
Pneumocystis carinii pneumonia occurs at some point in the course of disease in approximately 85 per cent of patients with AIDS. Because of the frequency of P. carinii pneumonia and because it is readily treatable, prompt, accurate, and efficient diagnostic schemes are of extreme importance. The clinical presentation
Masur H; Kovacs JA; Critical Care Medicine Department, National Institutes of Health,; Bethesda, Maryland.
Trimethoprim-sulfamethoxazole and parenteral pentamidine isethionate are effective in 60 to 80 per cent of AIDS patients with pneumocystis pneumonia. Adverse reactions are frequent with both agents, but because the adverse reactions are less severe with trimethoprim-sulfamethoxazole, this agent is the drug of choice f
Israelski DM; Remington JS; Department of Immunology and Infectious Diseases, Palo Alto; Medical Foundation, California.
Toxoplasmic encephalitis has been recognized as a major CNS complication in patients with AIDS and is the most frequent cause of focal intracerebral lesions in these patients. This complication of AIDS is almost always observed in patients who have a chronic (latent) infection with Toxoplasma gondii. Therefore, patien
Minamoto G; Armstrong D; Infectious Disease Service, Memorial Sloan-Kettering Cancer; Center, New York, New York.
Histoplasma capsulatum and Coccidioides immitis are two fungi that are regional in occurrence and cause opportunistic fungal infections in patients with AIDS. Many cases of histoplasmosis have been reported in patients months or years after they have been in an endemic area. These are obviously cases of reactivation o
Grant IH; Armstrong D; Infectious Disease Service, Memorial Sloan-Kettering Cancer; Center, New York, New York.
Cryptococcus neoformans, Histoplasma capsulatum, and Coccidioides immitis are the three fungi that regularly cause disseminated, life-threatening disease in patients with AIDS. Cryptococcosis is the fourth most common opportunistic infection in patients with AIDS and results in meningitis or pneumonia or both, in most
Jacobson MA; Department of Medicine, University of California, San Francisco.
Pulmonary or extrapulmonary tuberculosis occurs in 5 to 35 per cent of AIDS patients, frequently precedes the diagnosis of AIDS, and is increasing in incidence. Clinically, AIDS-associated tuberculosis is similar in presentation to progressive, primary tuberculosis and can be treated effectively with standard antitube
Chaisson RE; University of California, San Francisco.
Bacterial infections occur often in HIV-infected patients. Defects in both cell-mediated and humoral immunity are associated with an increased frequency of infections due to encapsulated and enteric bacteria. Pneumonia caused by Streptococcus pneumoniae, Haemophilus influenzae, and other pathogens may occur early in t
Cryptosporidium and Isospora belli are coccidian protozoan parasites that were long recognized as pathogens of animals. They were brought to the attention of the medical community by the advent of AIDS. These parasites are associated with persistent, devastating enteritis in patients with AIDS and self-limited diarrhe
Mitsuyasu RT; Department of Medicine, UCLA School of Medicine.
Kaposi s sarcoma is the most common malignancy seen in association with AIDS. Although the pathogenesis of AIDS-KS has not been clearly established, the clinical course and prognosis are closely related to the patient s immune status, prior history of opportunistic infection, and hematologic status. Treatment methods
Kaplan LD; University of California, San Francisco.
Patients with HIV infection, like immunosuppressed transplant recipients, are at high risk for the development of non-Hodgkin s lymphoma . These are high-grade lymphomas of B cell origin. Most patients present with advanced extralymphatic disease, and primary lymphoma of the central
Grossman M; University of California, San Francisco.
Eighty per cent of children with AIDS acquire their infection perinatally from infected mothers. Symptoms and signs appear in the first year of life and include failure to thrive, an increased number of bacterial infections, hepatomegaly, splenomegaly, lymphadenopathy, and progressive encephalopathy. Serious and multi
Stark E; Haas J; Malin JP; Brunkhorst U; Neurological Clinic, Hannover Medical School, Federal Republic of; Germany.
Although involvement of the central nervous system represents one of the most common manifestations of the acquired immunodeficiency syndrome (AIDS), a standard diagnostic test for this condition has not yet been established. At necropsy human immunodeficiency virus (HIV) has been demonstrated in brain macrophages in
Molgaard CA; Nakamura C; Hovell M; Elder JP; Division of Epidemiology and Biostatistics, Graduate School of; Public Health, San Diego State University, CA 92182.
Acquired Immunodeficiency Syndrome (AIDS) is characterized by a range of risk factors that determine susceptibility to HIV and the clinical expression of the disease. These include sexual practices, intravenous drug use, and blood exchange. Appropriate preventive measures have been formulated for these risk factors. T
Johnston BL; Poole CL; Zito DR; Normansell DE; Westervelt FB Jr; Farr BM; Department of Internal Medicine, University of Virginia Hospital,; Charlottesville.
In a longitudinal study to determine the seroprevalence of antibody to the human immunodeficiency virus (HIV) and the natural history of a positive enzyme immunoassay (EIA) result we followed a cohort of 98 patients receiving long-term dialysis. Eight patients (8.2%) in the cohort had a positive EIA and a negative Wes
AIDS Res Hum Retroviruses. 1988 Aug;4(4):243-50. Unique Identifier : AIDSLINE MED/89087762
Franchini G; Rusche JR; O'Keeffe TJ; Wong-Staal F; Laboratory of Tumor Cell Biology, National Cancer Institute,; Bethesda, MD 20892.
The HIV-2 genome contains an open reading frame (designated X-orf) that does not have a counterpart in HIV-1. To establish whether X-orf is a gene, we studied its expression in HIV-2-infected individuals and in infected cells in vitro. An HIV-2 proviral DNA fragment containing the X-orf was expressed in E. coli, and t
AIDS Res Hum Retroviruses. 1988 Aug;4(4):305-16. Unique Identifier : AIDSLINE MED/89087769
Makuch RW; Parks WP; Division of Biostatistics, Yale University School of Medicine,; New Haven, CT.
Levels of HIV-1 core polypeptide were assessed in serum and in lymphocyte cultures obtained from ARC and AIDS patients enrolled in a prospectively randomized, placebo-controlled study of zidovudine ( AZT ). Because these data have special features uncha
Mitsuyasu RT; Department of Medicine, UCLA School of Medicine, Los Angeles,; California 90024.
One of the most unusual manifestations of the acquired immunodeficiency syndrome is the cutaneous tumor, Kaposi s sarcoma. This rare and indolent tumor was once thought of as an interesting curiosity in Europe and Africa prior to the recognition of AIDS. Currently, however, this tumor accounts for approximately one qu
Uchiyama T; Department of Internal Medicine, Faculty of Medicine, Kyoto; University, Japan.
Adult T-cell leukemia (ATL) is a leukemia caused by a monoclonal expansion of HTLV-I-infected T-cells expressing a CD4 antigen. The clinical features of ATL include lymphadenopathy, hepatosplenomegaly, frequent skin lesions, hypercalcemia and a rapidly fatal course. The cell surface phenotype, cytogenetics and functio
Crit Care Clin. 1988 Jan;4(1):193-208. Unique Identifier : AIDSLINE MED/89089281
Kaiser LR; Hiatt JR; Division of Cardiothoracic Surgery, Washington University School; of Medicine, St. Louis, Missouri.
We have attempted to give a broad overview of issues of importance to the surgeon that may arise in the management of the immunocompromised patient. These include airway obstruction, diffuse and focal pulmonary lesions, vascular access problems, gastrointestinal bleeding, perforation, obstruction, and soft tissue infe
Macher AM; De Vinatea ML; Tuur SM; Angritt P; Collaborative Center for the Investigation of AIDS, Armed Forces; Institute of Pathology, Washington, DC.
Profoundly immunoincompetent, patients with AIDS are vulnerable to myriad opportunistic bacterial, viral, protozoal, and fungal pathogens. Opportunistic infections in patients with AIDS are often severe, persistent, and relapsing despite appropriate therapy. Some infections are virtually untreatable. This article desc
Histoplasmosis is a fungus disease of nearly worldwide distribution. Because of its wide distribution and tendency to be endemic near large cities, it is the most common systemic mycosis in the United States , with an estimated 500,000 new infections per year. Although millions of perso
JAMA. 1988 Dec 16;260(23):3481-3. Unique Identifier : AIDSLINE MED/89095087
Gerbert B; Maguire B; Badner V; Altman D; Stone G; Department of Dental Public Health and Hygiene, University of; California, San Francisco 94143-0754.
Over a period of 14 months (from October 1985 to December 1986) 152 potential cornea donors were evaluated for human immunodeficiency virus (HIV) and hepatitis B surface (HBs) antigen. In three clinically normal donors (two deaths due to natural causes, one as a result of an automobile accident), HIV seroconversion wa
el-Farrash MA; Badr MF; Hawas SA; el-Nashar NM; Imai J; Komoda H; Hinuma Y; Institute for Virus Research, Kyoto University.
Sera from 3,158 individuals living in northern Egypt were tested for the presence of antibodies against human T-lymphotropic virus type I (HTLV-I) by the newly developed particle agglutination (PA) test. Ten sera gave a positive reaction in the PA test. Eight of these sera were exam
Med Hypotheses. 1988 Nov;27(3):163-5. Unique Identifier : AIDSLINE MED/89096588
Yatvin MB; University of Wisconsin Medical School, Madison 53706.
Altering the biophysical characteristics of cell membranes by diet and membrane perturbing agents markedly influences thermosensitivity of cells. Likewise, manipulation of viral envelopes either by altering their lipid composition by diet or by the use of agents that perturb the lipid envelope influence infectivity of
The growing pandemia of AIDS, which resulted in about 40,000 AIDS patients and about 3 million infected persons by the end of 1986, demands for the urgent creation of methods for diagnosis, prevention and treatment of the disease. The present paper analyzes the main aspects of AIDS immunobiology, i. e. the molecular g
Buus DR; Pflugfelder SC; Schachter J; Miller D; Forster RK; Department of Ophthalmology, University of Miami School of; Medicine, Bascom Palmer Eye Institute, FL 33101.
The authors have recently treated a case of Parinaud s oculoglandular syndrome due to Chlamydia trachomatis serotype L2, a causative agent of lymphogranuloma venereum (LGV). The ocular manifestations included a mixed papillary-follicular conjunctivitis with fleshy superior limbal lesions in both eyes. A superior margi
Bekerman C; Bitran J; Department of Radiology, Michael Reese Hospital and Medical; Center, Chicago, IL 60616.
This review, examines the indications for and limitations of gallium-67 (67Ga) scanning in the evaluation of patients infected with human immunodeficiency virus (HIV). The imaging protocol, as well as the normal biodistribution of 67Ga and its normal variants are discussed. The diagnostic significance of the different
Bertram JH; Snyder HW Jr; Gill PS; Shulman I; Henry DH; Jenkins D; Kiprov DD; University of Southern California, Los Angeles.
Nine homosexual patients with immune thrombocytopenia were treated with autologous plasma that had been perfused over silica-immobilized Staphylococcus aureus protein A (SpA). Pretreatment platelet counts ranged from 10,000 to 98,000 cells/mm3 (mean: 54,000 cells/mm3). Six patients responded to therapy. Platelets incr
BMJ. 1988 Nov 5;297(6657):1178. Unique Identifier : AIDSLINE MED/89077053
Evengard B; von Sydow M; Ehrnst A; Pehrson PO; Lundbergh P; Linder E; Department of Parasitology, National Bacteriological Laboratory,; Stockholm, Sweden.
C R Acad Sci III. 1988;307(6):311-6. Unique Identifier : AIDSLINE MED/89077261
Bonnerot C; Savatier N; Nicolas JF; Unite de Biologie moleculaire du Developpement, C.N.R.S., U.A.; n. 1148, Institut Pasteur, Paris.
For a few of retroviruses, the level of synthesis of viral proteins is greatly increased in the presence of a transactivator gene which is encoded by the virus. For instance, for HIV, TAT acts on target sequences present in the viral long terminal repeat (LTR). HIV-1 recombinant retrovirus (RRV), where the gag, pol an
Green TL; Meyer JR; Daniels TE; Greenspan JS; de Souza Y; Kramer RH; Department of Stomatology, School of Dentistry, University of; California, San Francisco 94143-0424.
Early-stage lesions of Kaposi s sarcoma (KS) are composed of single-layered, highly flattened cells lining collagen bundles, whereas late-stage lesions contain densely packed, spindle-shaped cells. We examined the progression of KS lesions in oral mucosa and lymph nodes from patients with AIDS, using antibodies specif
Ups J Med Sci. 1988;93(2):189-92. Unique Identifier : AIDSLINE MED/89085443
Hogman CF; Blood Center, University Hospital, Uppsala, Sweden.
Although the scientific activity within blood preservation, plasma fractionation and treatment of coagulation disorders had been quite active in Sweden before 1978, the national coordination and self support with plasma products was insufficient. A programme for research and develo
AIDS Res Hum Retroviruses. 1988 Aug;4(4):251-8. Unique Identifier : AIDSLINE MED/89087763
Franchini G; Kanki PJ; Bosch ML; Fargnoli K; Wong-Staal F; Laboratory of Tumor Cell Biology, National Cancer Institute,; Bethesda, MD 20892.
Genetic comparison of SIVmac to the human retroviruses generally associated with AIDS revealed a closer relationship to HIV-2 than to HIV-1. A common feature differentiating SIV and HIV-2 from HIV-1 is the size of the transmembrane portion of the envelope, which is smaller (gp32) in SIVmac and HIV-2 than in HIV-1 (gp4
AIDS Res Hum Retroviruses. 1988 Aug;4(4):287-94. Unique Identifier : AIDSLINE MED/89087767
Yamada O; Hattori N; Kurimura T; Kita M; Kishida T; Department of Virology, Tottori University School of Medicine,; Yonago, Japan.
The effect of human natural interferons (IFN) alpha, beta, and gamma on the replication of human immunodeficiency virus (HIV) strain LAV in T cell lines TALL-1 and CCRF-CEM and peripheral blood lymphocytes (PBL) was studied. The growth of TALL-1 was moderately sensitive to these IFN, whereas that of CCRF-CEM was resis
Cancer Metastasis Rev. 1988 Dec;7(4):311-20. Unique Identifier : AIDSLINE MED/89090007
Hinrichs SH; Vogel J; Rhim MJ; Jay G; Laboratory of Molecular Virology, National Cancer Institute,; Bethesda, Maryland 20892.
The purpose of transgenic technology is to introduce a gene into the germline of an animal in order to investigate its proper expression in the appropriate cell types and its effect on cellular functions. This technology has been used to explore a wide variety of genetic and biological issues including stage- and tiss
Benjamin AE; University of California, San Francisco.
The driving concern of policy thinking in regard to both the elderly and AIDS patients has been cost containment. It has been presumed that the best way to cut costs, as well as to serve the medical and emotional needs of AIDS patients, is to limit hospital and nursing home stays and expand the role of community-based
Lin RY; Nygren EJ; Valinsky JE; Ralph HE; Metropolitan Hospital, New York.
Thirty-six intravenous drug users were studied for peripheral blood mononuclear cell (PBMC) immunophenotypes and human immunodeficiency virus (HIV) serological profiles. This population has a high risk for developing HIV infection. Half (18/36) were HIV antibody (Ab) negative (-) and half were positive (+). Total T ly
Levy JA; Department of Medicine, University of California, San Francisco.
HIV is a lentivirus that infects many tissues of the body, including the cells of the brain, the hematopoietic system, and the bowel epithelium. Its spread is mediated by virus-infected cells. Control of HIV depends on a strong host immune response against virus-infected cells, either through suppression of virus rele
Martini E; Muller JY; Gastal C; Doinel C; Meyohas MC; Roquin H; Frottier J; Salmon C; Laboratorie de Cytometrie en flux, Institut national de; transfusion sanguine, Paris.
Circadian variations in the number of circulating lymphocytes and their subpopulations have been observed in healthy subjects. These cyclic changes are characterized by a trough at 8:00 a.m. and a peak at midnight. Using multiple peripheral blood samplings, we were able to confirm that this cycle applied to CD4 T-cell
Presse Med. 1988 Nov 26;17(42):2240-2. Unique Identifier : AIDSLINE MED/89083834
Liotet S; Meyohas MC; Batellier L; Chaumeil C; Sainte Laudy J; Fribourg Blanc A; Frottier J; Centre hospitalier national d'Ophtalmologie des Quinze-Vingts,; Paris.
Serum histamine levels are significantly lowered in patients with human immunodeficiency virus (HIV) infection. Treatment with zidovudine has no effect on histaminaemia, but HIV-positive patients with thrombocytopenic purpura who underwent splenectomy are known to have had a rise in serum histamine levels after the op
AIDS Res Hum Retroviruses. 1988 Aug;4(4):269-78. Unique Identifier : AIDSLINE MED/89087765
Creemers PC; O'Shaughnessy M; Boyko WJ; Vancouver Lymphadenopathy-AIDS Study Group, St. Paul's Hospital,; B.C., Canada.
To investigate if serial measurement of T helper (CD4) lymphocyte number in peripheral blood is of prognostic value, we determined lymphocyte function in asymptomatic and symptomatic HIV antibody positive and negative homosexual males and related the results to absolute number of CD4 lymphocytes in peripheral blood. L
Weiner B; Perry RP; Magnusson J; Department of Psychology, University of California, Los Angeles; 90024.
In two experiments, we examined the perceived controllability and stability of the causes of 10 stigmas. Guided by attribution theory, we also ascertained the affective reactions of pity and anger, helping judgments, and the efficacy of five intervention techniques. In the first study we found that physically based st
Cell. 1988 Dec 23;55(6):1179-88. Unique Identifier : AIDSLINE MED/89077546
Green M; Loewenstein PM; Institute for Molecular Virology, St. Louis University School of; Medicine, Missouri 63110.
HIV-1 encodes a potent trans-activator protein, tat, which is essential for viral gene expression. To study tat domains that function in trans-activation, we chemically synthesized the 86 amino acid tat protein (tat-86) and tat mutant peptides. Remarkably, tat-86 is rapidly taken up by cells, and produces a massive an
Cell. 1988 Dec 23;55(6):1189-93. Unique Identifier : AIDSLINE MED/89077547
Frankel AD; Pabo CO; Department of Molecular Biology and Genetics, Johns Hopkins; University School of Medicine, Baltimore, Maryland 21205.
While developing an assay to measure the activity of the tat protein from human immunodeficiency virus 1 (HIV-1), we discovered that the purified protein could be taken up by cells growing in tissue culture and subsequently trans-activate the viral promoter. Trans-activation is dramatically increased by a variety of l
Price RW; Brew B; Cornell University Medical College, New York, New York.
The approach to neurologic diagnosis and management of HIV-infected and AIDS patients follows that used in general neurologic practice but takes into account the altered probabilities of differential diagnosis in this group of patients. Clinical and neurodiagnostic evaluations, when pursued with a background understan
Drew WL; Buhles W; Erlich KS; Laboratory Medicine, University of California, San Francisco.
Herpes viruses (HSV, CMV , VZ) are very frequent in AIDS patients and often exist in a chronic or progressive form. Clinically evident CMV retinitis occurs in approximately 10 per cent of AIDS patients but can be effectively treated with a new nucleoside analogue
J Med Virol. 1988 Nov;26(3):271-7. Unique Identifier : AIDSLINE MED/89080551
Eversole LR; Stone CE; Beckman AM; Department of Oral Diagnostic Sciences, University of Florida; College of Dentistry, Gainesville.
Oral hairy leukoplakia (OHL) is a white lesion of the oral mucosa, usually located on the lateral tongue among human immunodeficiency virus (HIV) positive acquired immunodeficiency syndrome (AIDS)-risk patients. The lesion has been reported to be associated with Epstein-Barr virus (EBV) and human papillomavirus (HPV).
Med Hypotheses. 1988 Sep;27(1):55-7. Unique Identifier : AIDSLINE MED/89082396
Topping RJ; Jones MM; Department of Chemistry, Vanderbilt University, Nashville,; Tennessee 37235.
While the commercially available sodium diethyldithiocarbamate (DEDTC) has been used by several groups in the treatment of AIDS patients, chemical evidence suggests that other dithiocarbamates which are more stable at pH 7.4 might prove to be quite superior for this purpose. Of these other compounds, sodium pyrrolidin
Med Hypotheses. 1988 Sep;27(1):83-4. Unique Identifier : AIDSLINE MED/89082402
Salomon JC; C.N.N.R.S., Villejuif, France.
HIV may induce subclinical neuroendocrine dysfunctions in some seropositive patients and these dysfunctions may be one of the co-factors that determine the pathogenesis of AIDS.
Park RE; Haseltine WA; Rosen CA; Department of Pathology, Dana-Farber Cancer Institute, Harvard; Medical School, Boston, Massachusetts 02115.
Human T-cell Leukemia Virus (HTLV-I) gene expression is regulated by both constitutive and inducible enhancer elements. The viral components required for inducible enhancer function include the cis-acting 21 bp motifs present three times within the U3 region of the LTR and the trans-acting 40 kD tax protein encoded by
Ferreiro J; Vinters HV; Department of Pathology, UCLA Medical Center.
The pituitary gland was examined at autopsy in 88 patients who died with acquired immune deficiency syndrome (AIDS) or AIDS-related complex (ARC). Pathologic findings included focal to widespread necrosis and/or fibrosis of the anterior pituitary gland in 10 cases, evidence of cytomega
S Afr Med J. 1988 Dec 17;74(12):610-4. Unique Identifier : AIDSLINE MED/89084733
Becker WB; Engelbrecht S; Becker ML; Piek C; Robson BA; Wood L; Jacobs P; Department of Medical Virology, University of Stellenbosch; Parowvallei, CP.
A new human helper (CD4) T-lymphotropic herpesvirus (HTLHV) was first isolated in February 1985 from the cultured peripheral blood lymphocytes (PBL) of a patient with the acquired immunodeficiency syndrome, and subsequently from the PBL of 1 patient with hairy cell leukaemia and 2 patients with lymphoproliferative dis
Ann Neurol. 1988 Dec;24(6):713-7. Unique Identifier : AIDSLINE MED/89087112
Mah V; Vartavarian LM; Akers MA; Vinters HV; Department of Pathology, UCLA Medical Center 90024-1732.
The purpose of this study was to assess systematically morphology of peripheral nerves from patients with human immunodeficiency virus infection (acquired immunodeficiency syndrome [AIDS] and AIDS-related complex) examined at autopsy. Sural nerve specimens were taken from 25 patients (mean age 44 years) and evaluated
Biomed Environ Mass Spectrom. 1988 Nov;17(5):399-404. Unique Identifier : AIDSLINE MED/89088637
Rubio FR; Crews T; Garland WA; Fukuda EK; Department of Drug Metabolism, Hoffmann-La Roche Inc, Nutley, New; Jersey 07110.
A gas chromatographic/mass spectrometric procedure has been developed for the quantification in plasma of dideoxycytidine (DDC), a candidate anti-AIDS drug. The assay uses an extraction with ethyl acetate containing 10% methanol followed by three derivatization steps: (i) reaction with t-butyl dimethyl chlorosilane to
CLAO J. 1988 Jul-Sep;14(3):165-8. Unique Identifier : AIDSLINE MED/89090117
Pepose JS; Department of Ophthalmology, Washington University School of; Medicine, St. Louis, MO 63110.
Current FDA standards for contact lens disinfecting systems require that viricidal activity be demonstrated against just one strain of herpes simplex virus, type 1. Small and nonenveloped viruses (e.g., adenoviruses) may be more resistant to disinfection than herpes simplex virus (HSV
Kinney JS; Kumar ML; Department of Pediatrics, Johns Hopkins School of Medicine,; Baltimore, Maryland.
Physicians faced with a newborn infant with signs and symptoms of perinatal infection must consider a multitude of diseases, and may need to embark on a complex differential diagnosis. As stated by Alford in 1967, neonatal diagnoses of infections acquired in utero, natally and postnatally, are inherently difficult. Tw
Ueta Y; Tada J; Hashimoto T; Tsuji S; Murai Y; Department of Neurology, School of Medicine, University of; Occupational and Environmental Health, Kitakyushu, Japan.
A 42-year-old woman with progressive myelopathy and mononeuritis multiplex is reported. The neurological examination on admission revealed hyperreflexia of the four extremities with pathological reflexes and moderate muscle weakness of the lower extremities with spasticity. Sensory disturbance was distributed on the a
Vet Pathol. 1988 Nov;25(6):456-67. Unique Identifier : AIDSLINE MED/89101458
Baskin GB; Murphey-Corb M; Watson EA; Martin LN; Delta Regional Primate Research Center, Tulane University,; Covington, LA.
Lesions induced in rhesus monkeys by different isolates of simian immunodeficiency virus (SIV)/Delta were studied at necropsy. Four groups of monkeys were inoculated with SIV/Delta isolated from other experimentally infected rhesus monkeys, while one group was inoculated with SIV/Delta from an asymptomatic mangabey mo
Minagawa H; Sakuma S; Mohri S; Mori R; Watanabe T; Department of Virology, School of Medicine, Kyushu University,; Fukuoka, Japan.
Herpes simplex virus type 1 (HSV-1) infection in mutant mice with severe combined immunodeficiency (SCID mice), i.e., mice in which the differentiation of both T and B lymphocytes is severely impaired, was studied. All control (infected and not treated with antibodies or with immune spleen cells) SCID mice were dead b
Hierholzer JC; Adrian T; Anderson LJ; Wigand R; Gold JW; Respiratory and Enteric Viruses Branch, Centers for Disease; Control, Atlanta, Georgia.
We carried out detailed antigenic and restriction enzyme (RE) analyses on the subgenus B and D adenovirus isolates from 48 AIDS patients. These isolates were unusual both in the diversity of serotypes and in the number of intermediate strains identified. All unusual isolates were strain-purified and tested by serum ne
Chang KS; Wang LC; Gao CL; Alexander S; Ting RC; Bodner A; Log T; Kuo AF; Strickland P; Laboratory of Cellular Oncology, National Cancer Institute,; Bethesda, MD 20892.
Serum samples collected from four groups of individuals in the Washington, D.C. area were examined for the presence of IgG and IgM classes of antibody reacting against HTLV-I and HIV-1. These four groups were: (1) healthy adults with negative premarital VDRL test for syphilis (n = 113), (2) miscellaneous common diseas
Lesbordes JL; Martin PM; Ravisse P; Georges-Courbot MC; Georges AJ; Centre National Hospitalier et Universitaire, Bangui (Republique; Centrafricaine).
From 1983 to 1987, 45 Kaposi s sarcomas (KS) were diagnosed at the University Hospital in Bangui; 37 cases were easily classified as either endemic or AIDS-related KS on clinical grounds and HIV serology. Moreover, probably due to the stage at which patients consulted and lesions were sampled, noticeable histopatholog
Thomson BJ; Dalgleish AG; National Institute for Medical Research, London, UK.
After many unsuccessful years of searching, the first pathogenic human retrovirus, the human T-cell leukaemia lymphoma virus (HTLV-I), was reported as recently as 1980 and since that time has been causally linked to the adult T-cell leukaemia lymphoma syndrome. A second HTLV (HTLV-II) isolated shortly afterwards is le
Bottiger B; Blomback M; Berntorp E; Egberg N; Nilsson IM; Schulman S; Stigendal L; Biberfeld G; Department of Immunology, National Bacteriological Laboratory,; Stockholm, Sweden.
389 Swedish patients with haemophilia A, B or von Willebrand s disease were examined for HIV-1 antibodies. T-cell subsets were measured in 260 of them. HIV-1 antibodies were found in 98 of these patients. Of the 199 patients with severe or moderate haemophilia A, 44% were seropositive. They had seroconverted between 1
Kashiwagi S; Ikematsu H; Hayashi J; Kajiyama W; Nomura H; Noguchi A; Tani S; Goto M; First Department of Internal Medicine, Faculty of Medicine,; Kyushu University, Fukuoka.
A total of 2,283 serum samples were collected from healthy subjects in three islands of the Yaeyama district of Okinawa, Japan . These sera were tested for the presence of hepatitis B surface antigen (HBsAg), for antibody to hepatitis B core antigen (anti-HBc), and for antibody to ad
Jeanmonod R; Harding T; Institut universitaire de medecine legale, Geneve.
Over the past twenty years, the proportion of drug dependent inmates has risen dramatically in the prisons of Western Europe. In the Geneva romand prison, where about 30% of entries present problems of opiate abuse and dependence, treatment of withdrawal symptoms with decreasing doses of methadone over a period of 5-1
Can Med Assoc J. 1989 Jan 1;140(1):64A-64D. Unique Identifier : AIDSLINE MED/89077338
The following general principles serve as guidelines for various bodies, health care professionals and the general public. Specific aspects of infection with human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS) that relate to physicians ethical responsibilities as well as society s moral o
Reddy MM; Grieco MH; Allergy and Cellular Immunology Laboratory, R. A. Cooke Institute; of Allergy, St. Luke's-Roosevelt Hospital Center, New York, New; York.
Ezekowitz RA; Kuhlman M; Groopman JE; Byrn RA; Division of Hematology/Oncology, Harvard Medical School, Boston,; Massachusetts.
In vitro infection by the human immunodeficiency virus (HIV) of CD4+ H9 lymphoblasts is inhibited by a mannose-binding protein (MBP) purified from human serum. In addition, MBP is able to selectively bind to HIV-infected H9 cells and HIV-infected cells from the monocyte cell line U937. These results indicate MBP most
J Med Chem. 1989 Jan;32(1):73-6. Unique Identifier : AIDSLINE MED/89081341
Scheiner P; Geer A; Bucknor AM; Imbach JL; Schinazi RF; York College, City University of New York, Jamaica 11451.
An acyclic derivative of 3 -azido-3 -deoxythymidine, (R,S)-1-[1-(2-hydroxyethoxy)-3-azidopropyl]thymine (2), has been synthesized by a path involving Michael-type addition. Related thymidine analogues lacking the C(3 )-C(4 ) bond were similarly obtained. The method provides a versatile new route to nucleoside analogue
J Med Chem. 1989 Jan;32(1):76-9. Unique Identifier : AIDSLINE MED/89081342
Abushanab E; Sarma MS; Department of Medicinal Chemistry, University of Rhode Island,; Kingston 02118.
1 ,2 -seco-2 ,3 -Dideoxycytidine (12), -guanosine (14), adenosine (16), and -inosine (18) were prepared from (R)-benzylglycidol as potential anti-HIV agents. When compared to ddAdo in protecting ATH8 cells, they were found to be inactive.
JAMA. 1989 Jan 20;261(3):393-7. Unique Identifier : AIDSLINE MED/89081430
Braun MM; Truman BI; Maguire B; DiFerdinando GT Jr; Wormser G; Broaddus R; Morse DL; Bureau of Communicable Disease Control, New York State Department; of Health, Albany, NY 12237.
The incidence of tuberculosis (TB) among inmates of the New York State prison system increased from 15.4 per 100,000 in 1976 through 1978 to 105.5 per 100,000 in 1986. Matching of TB and acquired immunodeficiency syndrome registries indicated that the majority (56%) of inmates with TB reported in 1985 and 1986 had acq
JAMA. 1989 Jan 20;261(3):411-3. Unique Identifier : AIDSLINE MED/89081434
Schlech WF 3d; Lee SH; Cook J; Rozee KR; MacIntosh N; Department of Medicine, Faculty of Medicine, Dalhousie; University, Halifax, Nova Scotia.
Two newborns of mothers carrying hepatitis B and at high risk for human immunodeficiency virus (HIV) infection developed HIV-positive test results by enzyme-linked immunosorbent assay and Western blot tests after birth. Both had been administered hepatitis B immune globulin within 48 hours of birth. Serological tests
JAMA. 1989 Jan 27;261(4):561-5. Unique Identifier : AIDSLINE MED/89081459
Chaisson RE; Bacchetti P; Osmond D; Brodie B; Sande MA; Moss AR; Medical Service, San Francisco General Hospital.
We assessed risk factors for human immunodeficiency virus (HIV) infection in 633 heterosexual intravenous drug users. The HIV seroprevalence was 26% in blacks, 10% in Hispanics, and 6% in whites. Intravenous cocaine use significantly increased the risk of HIV infection, with a seroprevalence of 35% in daily cocaine us
Edwards VM; Mosley JW; Department of Medicine, University of Southern California, Los; Angeles 90032.
The protein (Western) immunoblot assay (IB) for antibodies to human immunodeficiency virus, like other laboratory procedures, sometimes gives variable results. In the Transfusion Safety Study, indistinguishable aliquots of four quality control (QC) samples have been routinely submitted for IB with each group of patien
Am J Med. 1989 Jan;86(1):27-31. Unique Identifier : AIDSLINE MED/89086460
Grunfeld C; Kotler DP; Hamadeh R; Tierney A; Wang J; Pierson RN; Metabolism Section, Veterans Administration Medical Center, San; Francisco, California 94121.
PURPOSE: A relationship between the induction of hypertriglyceridemia by cytokines and the cachexia seen in chronic infection has been proposed by other investigators. Since patients with the acquired immunodeficiency syndrome (AIDS) often experience progressive tissue wasting, we decided to examine serum lipid levels
Am J Med. 1989 Jan;86(1):71-6. Unique Identifier : AIDSLINE MED/89086468
Bermudez MA; Grant KM; Rodvien R; Mendes F; Department of Pathology, Pacific Presbyterian Medical Center, San; Francisco, California 94115.
PURPOSE: An increased risk of malignancies, including Kaposi s sarcoma and non-Hodgkin s lymphoma , is found in patients infected with the human immunodeficiency virus type 1 (HIV-1). Treatment of such patients may be complicated by their underlying immunodeficiency, especially when
Duncan WC; Kelsey-Seybold Clinic, Baylor College of Medicine, Houston.
The case presented here involves a 32-year-old homosexual man with human immunodeficiency virus seropositivity and secondary syphilis. Because of possible penicillin allergy, he was initially treated with erythromycin base by mouth. During four weeks of therapy, his cutaneous lesions worsened as did his systemic sympt
Adams JS; Fernandez M; Gacad MA; Gill PS; Endres DB; Rasheed S; Singer FR; Department of Medicine, University of Southern California School; of Medicine, Los Angeles.
Fifteen patients with lymphoma and hypercalcemia (greater than or equal to 11.0 mg/dL) were identified by screening the serum chemistry profile obtained from patients upon admission to the Los Angeles County/USC Medical Center. Seven of the 15 (47%) possessed a frankly elevated serum concentration of 1,25-dihydroxyvit
Cancer. 1989 Jan 15;63(2):289-94. Unique Identifier : AIDSLINE MED/89089529
Shimamoto Y; Ono K; Sano M; Matsuzaki M; Suga K; Sueoka E; Tokioka T; Yamaguchi M; Suzuki H; Sato H; et al; Department of Internal Medicine, Saga Medical School, Japan.
Prognostic factors affecting the survival of adult T-cell leukemia (ATL) patients were analyzed in three groups: total cases, leukemia type cases, and lymphoma type cases. Factors found to be important overall, i.e. for total cases, were leukocyte count, ATL cell ratio in the peripheral blood, serum calcium levels and
Cancer Res. 1989 Jan 15;49(2):466-70. Unique Identifier : AIDSLINE MED/89089595
Bernstein L; Levin D; Menck H; Ross RK; Department of Preventive Medicine, University of Southern; California School of Medicine, Los Angeles 90033.
Data from the population-based cancer registry for Los Angeles County, an area with high risk of AIDS, were used to evaluate secular trends of Kaposi s sarcoma (KS), non-Hodgkin s lymphoma , and other possibly AIDS-related cancers in men aged 18 to 54. Marital status was used as a s
Mitra G; Dobkin MB; Wong MF; Mozen MM; Biological Research and Development, Cutter Biological, Miles; Inc., Berkeley, Calif.
Concern for virus transmission from intravenous biological products, derived from natural and biotechnological sources, has prompted us to investigate various methods for virus inactivation while preserving the biological activity of the therapeutic entity. This concern is currently acute regarding the presence of HIV
Thompson GB; Pemberton JH; Morris S; Bustamante MA; Delong B; Carpenter HA; Wright AJ; Department of Surgery, Mayo Medical School, Rochester, Minnesota.
In the United States , visceral Kaposi s sarcoma most commonly occurs in association with the acquired immune deficiency syndrome (AIDS). The authors report a unique case of primary colonic Kaposi s sarcoma in a young heterosexual HIV-negative man with chronic ulcerative colitis.
Rey MA; Krust B; Laurent AG; Montagnier L; Hovanessian AG; Unite d'Oncologie Virale (Unite Associee CNRS 1157), Institut; Pasteur, Paris, France.
Four glycoproteins with apparent molecular weights of 300,000, 140,000, 125,000, and 36,000 (gp300, gp140, gp125, and gp36) were detectable in human immunodeficiency virus type 2 (HIV-2)-infected cells. gp125 and gp36 are the external and transmembrane components, respectively, of the envelope glycoproteins of HIV-2 m
Horvat RT; Wood C; Balachandran N; Department of Microbiology, University of Kansas, Lawrence 66045.
Patients with acquired immunodeficiency syndrome (AIDS) are often infected with a number of other heterologous viruses in addition to the initial human immunodeficiency virus (HIV) infection, and these agents could act as potential reactivating agents of latent HIV. A new antigenically distinct herpesvirus, designated
JAMA. 1989 Feb 3;261(5):725-7. Unique Identifier : AIDSLINE MED/89095115
Jason J; Lui KJ; Ragni MV; Hessol NA; Darrow WW; Division of Host Factors, Centers for Disease Control, Atlanta,; GA 30333.
The latency period and/or incidence of the acquired immunodeficiency syndrome (AIDS) may differ in persons infected with the human immunodeficiency virus by different routes or having different cofactors. We compared 79 hemophilic men in Pennsylvania and 117 homosexual and bisexual men in California, all having known
Schiff M; Katz A; Farber B; Kaplan M; Department of Medicine, North Shore University Hospital,; Manhasset, N.Y. 11030.
We identified 13 patients who contracted acquired immunodeficiency syndrome or human immunodeficiency virus-related disease after a cardiothoracic operation. The operations were performed between January 1981 and November 1984, and the diagnosis of human immunodeficiency virus-related disease was established from 26 t
Sperling RS; Sacks HS; Mayer L; Joyner M; Berkowitz RL; Department of Obstetrics, Gynecology, and Reproductive Science,; Mount Sinai Medical Center, New York, New York.
The potential spread of the human immunodeficiency virus (HIV) to childbearing women in areas of high acquired immunodeficiency syndrome (AIDS) endemicity is a major public health concern. As a private institution providing obstetric care to such a population of women, we undertook an anonymous HIV cord blood serosurv
Shibahara S; Mukai S; Morisawa H; Nakashima H; Kobayashi S; Yamamoto N; Central Research Laboratories, Ajinomoto Co., Inc., Kawasaki,; Japan.
Several synthetic 2 -O-methyl-RNA oligomers and their derivatives have been evaluated for inhibitory effect against HIV-induced cytopathic effect and expression of the virus specific antigen in cultured MT-4 cells. In this study, oligo(2 -O-methyl)ribonucleoside phosphorothioates showed a potent inhibitory activity wi
Proc Natl Acad Sci U S A. 1989 Jan;86(1):332-6. Unique Identifier : AIDSLINE MED/89098910
Balzarini J; Naesens L; Herdewijn P; Rosenberg I; Holy A; Pauwels R; Baba M; Johns DG; De Clercq E; Rega Institute for Medical Research, Katholieke Universiteit; Leuven, Belgium.
9-(2-Phosphonylmethoxyethyl)adenine (PMEA) is a potent and selective inhibitor of the replication of human immunodeficiency virus (HIV) in vitro in human T-lymphocyte MT-4, H9, and ATH8 cells. PMEA also inhibits Moloney murine sarcoma virus (Mo-MSV)-induced transformation of murine C3H embryo fibroblasts. Moreover, PM
Science. 1989 Jan 20;243(4889):338-48. Unique Identifier : AIDSLINE MED/89100277
Fay RE; Turner CF; Klassen AD; Gagnon JH; Committee on AIDS Research, National Academy of Sciences,; Washington, DC 20418.
The prevalence and patterns of same-gender sexual contact among men are key components of models of the spread of HIV infection and AIDS in the U.S. population. Previous estimates by Kinsey et al. from data collected between 1938 and 1948 have been widely criticized for inadequacies of sample design. New lower-bound e
Science. 1989 Jan 20;243(4889):378-81. Unique Identifier : AIDSLINE MED/89100284
Allen JM; Seed B; Department of Molecular Biology, Massachusetts General Hospital,; Boston 02114.
Human and murine mononuclear phagocytes express a high-affinity receptor for immunoglobulin G that plays a central role in macrophage antibody-dependent cellular cytotoxicity and clearance of immune complexes. The receptor (FcRI) may also be involved in CD4-independent infection of human macrophages by human immunodef
Tidsskr Nor Laegeforen. 1989 Jan 10;109(1):66-7. Unique Identifier : AIDSLINE MED/89100968
Fossum S; Skogstad M
Heterosexual dissemination of HIV is increasing in Norway . Women are apparently more exposed than men. 70% of Norwegian HIV-cases attributed to domestic heterosexual transmission are women. The two groups of sexual partners that most frequently infect Norwegian women with HIV are d
Wiltbank TB; McCarroll DR; Wartick MG; Department of Pathology, University of Illinois College of; Medicine, Peoria.
Since the institution of routine testing for antibodies to Human Immunodeficiency Virus (HIV) using the enzyme-linked immunosorbent assay (ELISA), the specificity and sensitivity of this assay system has received significant scrutiny. During previous use of this methodology, we have quantified rates of false biologica
Dummer JS; Erb S; Breinig MK; Ho M; Rinaldo CR Jr; Gupta P; Ragni MV; Tzakis A; Makowka L; Van Thiel D; et al; Department of Medicine, University of Pittsburgh School of; Medicine, Pennsylvania.
We performed a retrospective serologic survey of 583 organ donors and 1043 transplant recipients for antibodies to human immunodeficiency virus type 1 (HIV-1). Two (0.34%) of the 583 donors and 18 (1.7%) of the 1043 recipients had HIV-1 antibodies by enzyme immunoassay and by Western blot. Two of 5 seropositive recipi
Horsburgh CR Jr; Selik RM; AIDS Program, Centers for Disease Control, Atlanta, Georgia; 30333.
We analyzed cases of disseminated nontuberculous mycobacterial infection (DNTM) in patients with AIDS reported to the Centers for Disease Control. Between 1981 and 1987, 2,269 cases were reported. In 96% of cases, infection was caused by M. avium complex (MAC). The number of cases has risen steadily since 1981, but th
Biochem Biophys Res Commun. 1989 Jan 16;158(1):307-12. Unique Identifier : AIDSLINE MED/89105078
Ito M; Baba M; Sato A; Hirabayashi K; Tanabe F; Shigeta S; De Clercq E; Department of Bacteriology, Fukushima Medical College, Japan.
The effect of tumor necrosis factor (TNF) on the replication of human immunodeficiency virus type 1 (HIV-1) was investigated in several T4 lymphocyte cell lines. TNF markedly enhanced the cytopathogenicity of HIV-1, virion-associated reverse transcriptase (RT) activity in the cell culture supernatant, and viral antige
O'Brien RF; Quinn JL; Miyahara BT; Lepoff RB; Cohn DL; Department of Medicine, (Pulmonary and Infectious Disease; Divisions), Denver General Hospital, University of Colorado; Health Sciences Center.
Examination of induced sputum from AIDS patients has been reported to provide the noninvasive diagnosis of PCP in 10 to 76 percent of cases. Since previous studies were done in centers with a high incidence of AIDS, we asked whether this test could be implemented successfully in a center with a lower incidence of AIDS
Lucey DR; Dorsky DI; Nicholson-Weller A; Weller PF; Department of Medicine, Harvard Medical School, Boston,; Massachusetts.
The CD4 glycoprotein, expressed on leukocytes belonging to subsets of T lymphocytes and to cells of monocyte/macrophage lineage, participates in the functioning of T cells and serves as a receptor for HIV-1 and HIV-2. Human eosinophils, a class of granulocytic leukocytes, have been found to express CD4. With anti-CD4
Am J Med. 1989 Jan;86(1):11-4. Unique Identifier : AIDSLINE MED/89086442
Schlamm HT; Yancovitz SR; Department of Medicine, Beth Israel Medical Center, New York, New; York.
PURPOSE: Since the acquired immunodeficiency syndrome (AIDS) was first described in 1981, we have observed an increasing number of cases of Haemophilus influenzae pneumonia, particularly in young adult patients. To confirm this observation, we systematically identified and reviewed all cases of H. influenzae pneumonia
Tschachler E; Robert-Guroff M; Gallo RC; Reitz MS Jr; Laboratory of Tumor Cell Biology, National Cancer Institute,; Bethesda, MD 20892.
We have studied the pattern of expression of the lymphokines tumor necrosis factor (TNF alpha) and lymphotoxin (TNF beta) in T-cell lines established by transformation with human T-lymphotropic virus, type I (HTLV-I), the etiologic agent of adult T-cell leukemia (ATL). We report here that nine of nine HTLV-I-infected
Cancer. 1989 Jan 1;63(1):158-63. Unique Identifier : AIDSLINE MED/89089494
Armitage JO; Greer JP; Levine AM; Weisenburger DD; Formenti SC; Bast M; Conley S; Pierson J; Linder J; Cousar JB; et al; Department of Medicine, University of Nebraska Medical Center,; Omaha 68105.
Peripheral T-cell lymphoma is the most common type of T-cell lymphoma seen in adults in the United States . Clinical data were reviewed from 134 cases of peripheral T-cell lymphoma diagnosed in three centers. The median age of the patients was 57 years (range, 4-97 years), 59% were male
Hahn T; Schattner A; Handzel ZT; Levin S; Bentwich Z; Department of Pediatric Research, Kaplan Hospital, Rehovot,; Israel.
In an attempt to assess the role of immune cytotoxic activity in the sequence of events leading to the acquired immunodeficiency syndrome (AIDS), natural cytotoxic activity was studied in 17 asymptomatic homosexual males, seropositive for anti-human immunodeficiency virus (HIV) antibodies, as compared to 16 of their s
J Immunol. 1989 Jan 15;142(2):531-6. Unique Identifier : AIDSLINE MED/89093936
Nakajima K; Martinez-Maza O; Hirano T; Breen EC; Nishanian PG; Salazar-Gonzalez JF; Fahey JL; Kishimoto T; Institute for Molecular and Cellular Biology, Osaka University,; Japan.
Polyclonal B cell activation is commonly observed in AIDS and in infection with HIV. The effect of HIV on the induction of B cell stimulatory factor 2 (BSF-2) production was examined, since BSF-2 plays an essential role in the differentiation of activated B cells to Ig-secreting cells. Increased BSF-2 mRNA levels and
Anand R; Thayer R; Srinivasan A; Nayyar S; Gardner M; Luciw P; Dandekar S; Biochemical Genetics Branch, National Institute of Mental Health,; Washington, D.C. 20032.
HIV-1BR was isolated from the autopsied brain tissue of a 57-year-old man who died of progressive dementing illness. This virus was shown to be HIV-1 by hybridization to HIV-specific DNA probes. The expression of viral proteins as tested by radioimmunoprecipitation assay revealed the presence of HIV-1-specific protein
Chaisson RE; Slutkin G; Department of Medicine, Johns Hopkins University School of; Medicine, Baltimore, Maryland.
Progressive human immunodeficiency virus infection eventually leads to activation and dissemination of a wide variety of microorganisms normally held in check by the cellular immune system. Mycobacterium tuberculosis is one of these pathogens, and the disease caused by it has become a common presenting infection in th
Nakamura T; Tsujihata M; Shirabe S; Matsuo H; Ueki Y; Nagataki S; First Department of Internal Medicine, Nagasaki, University; School of Medicine, Japan.
We have established an interleukin 2-dependent, OKT4-positive T-cell line, named HCT-1, from cells in the cerebrospinal fluid obtained from a patient with human T-cell lymphotropic virus type I (HTLV-1)-associated myelopathy. Antigens for HTLV-I were detected in HCT-1 cells by indirect immunofluorescence and Western b
Can Med Assoc J. 1989 Jan 15;140(2):137-42. Unique Identifier : AIDSLINE MED/89089468
Klingemann HG; Cancer Control Agency of British Columbia, Vancouver General; Hospital, BC.
The differentiation and maturation of hematopoietic progenitor cells are regulated by certain growth factors. Several of these glycoproteins have been characterized, and their amino acid sequences have been delineated. Modern DNA technology provides sufficient quantities of these hormones for testing in clinical trial
Aiuti F; Sirianni MC; Mezzaroma I; D'Offizi GP; Pesce AM; Papetti C; Ensoli F; Luzi G; Department of Allergy and Clinical Immunology, University of Rome; La Sapienza, Italy.
A combined treatment of plasma or plasma derivatives by beta-propiolactone (beta-PL)/UV irradiation is in use at Biotest for the preparation of the virus-safe, stabilized serum (Biseko) and coagulation factor concentrates. The efficacy of this sterilization procedure has been demonstrated for HAV (greater than 8.2 log
Holmes VF; Fernandez F; Levy JK; Department of Psychiatry and Behavioral Science, State University; of New York, Stony Brook 11794-8101.
Methylphenidate or dextroamphetamine was used to treat 17 of 32 patients with AIDS-related complex who were referred for neuropsychiatric evaluation of symptoms representative of cognitive and/or affective dysfunction. All 17 patients were found to have some degree of cognitive impairment. Psychiatric diagnoses includ
Poon T; Matoso I; Tchertkoff V; Weitzner I Jr; Gade M; Department of Pathology, New York Medical College, Metropolitan; Medical Centers, NY.
Computed tomographic study of six cases with primary cerebral non-Hodgkin lymphoma are reviewed. Three had a history of intravenous drug abuse and were diagnosed as having acquired immunodeficiency syndrome (AIDS). All cases presented with space occupying lesions in the frontal lobe with the exception of Case 4. Compu
van der Laan RT; Verbeeten B Jr; Smits NJ; Lubbers MJ; Department of Diagnostic Radiology, University of Amsterdam, The; Netherlands.
Solitary splenic abscess is a rare entity and difficult to diagnose. Late recognition results in a high mortality. Recently percutaneous drainage has proved to be beneficial. The CT and ultrasound findings of two patients with splenic abscesses are reported. In one patient the solitary splenic abscess was drained perc
Nord Med. 1989;104(1):16-7. Unique Identifier : AIDSLINE MED/89098290
Austgulen R
Hematologic growth factors are now assessible in recombinant forms, and thus available in amounts making cliical use possible. Erythropoietin, which induces differentiation and proliferation of the red blood cells, is produced by recombinant techniques. Clinical trials have shown the effectiveness of erythropoietin in
Science. 1989 Jan 13;243(4888):223-6. Unique Identifier : AIDSLINE MED/89100264
Ensoli B; Nakamura S; Salahuddin SZ; Biberfeld P; Larsson L; Beaver B; Wong-Staal F; Gallo RC; Laboratory of Tumor Cell Biology, National Cancer Institute,; Bethesda, MD 20892.
When grown in vitro, cells from Kaposi s sarcoma lesions of AIDS patients (AIDS-KS cells) constitutively release several growth promoting activities. When inoculated into nude mice, the AIDS-KS cells induce a KS-like lesion of mouse origin. Here it is shown that the AIDS-KS cells express messenger RNA for a complex mi
To prevent the transmission of human T-lymphotropic virus, type 1 (HTLV-1) during blood transfusion, a program was implemented to screen donors for antibodies to the virus, using a newly developed, passive agglutination (PA) method. During the period April 1986 to March 1987, 675 recipients of donor blood in whom the
Thorn RM; Braman V; Stella M; Yi A; Cambridge BioScience Corporation, Worcester, MA 01605.
Three FDA licensed HIV-1 viral lysate and two nonlicensed recombinant antigen assays were used to evaluate six serially diluted plasma samples and 2 highly characterized seroconversion series. The sensitivity as measured by serial dilution did not necessarily correlate with the sensit
Chiavetta JA; Nusbacher J; Wall A; Toronto Centre, Canadian Red Cross Blood Transfusion Service,; Ontario.
Donor behavior in completing a pre-donation confidential self-exclusion form, which identified blood donors at high-risk of AIDS exposure, was evaluated. The form was completed by all donors during a 12 month period beginning in September, 1985. 188,824 units of blood were collected from 123,608 donors. On the first d
Toba H; Crawford JT; Ellner JJ; Department of Medicine, Case Western Reserve University,; Cleveland, Ohio.
Mycobacterium avium is a frequent opportunistic pathogen in the acquired immunodeficiency syndrome (AIDS). We compared 12 strains of M. avium in an in vitro model of pathogenicity. Peripheral blood-derived monocytes from healthy individuals were infected with M. avium in vitro. Bacterial uptake and intracellular repli
Agostini C; Semenzato G; Vinante F; Sinicco A; Trentin L; Zambello R; Zuppini B; Zanotti R; Siviero F; Veneri D; et al; Department of Clinical Medicine, Padua University, Italy.
In this study we investigated the serological levels of the soluble form of the CD8 molecule (s-CD8) in 97 human immunodeficiency virus (HIV) seropositive patients. The control groups included 20 normal heterosexual subjects and 19 healthy seronegative subjects belonging to risk groups for AIDS. Our results show that
Schreiber AB; Hrinda ME; Newman J; Tarr GC; D'Alisa R; Curry WM; Rorer Biotechnology Inc., King of Prussia, Pa.
The transmittance of pathogenic viruses by the widespread administration of protein fractions such as F VIII prepared on a large scale from pooled human plasma has been of growing concern. We have now demonstrated that significant amounts of pathogenic viruses including LAV/HTLVIII may be removed by a new large scale
J Immunol. 1989 Jan 15;142(2):500-8. Unique Identifier : AIDSLINE MED/89093931
Faltynek CR; Finch LR; Miller P; Overton WR; Biological Carcinogenesis Development Program, National Cancer; Institute, Frederick, MD 21701.
The human cell surface protein CD4 is not only an important accessory molecule in the activation of MHC class-II-restricted T cells, but has also been implicated to be a receptor for the human immunodeficiency virus HIV-I on lymphoid and monocytic cells. We have found that a 24-h treatment of the promonocytic leukemia
Proc Natl Acad Sci U S A. 1989 Jan;86(2):675-9. Unique Identifier : AIDSLINE MED/89098993
McElrath MJ; Pruett JE; Cohn ZA; Laboratory of Cellular Physiology and Immunology, Rockefeller; University, New York, NY 10021.
We examined human immunodeficiency virus (HIV) production in cultured mononuclear cells from 36 seropositive homosexual males. Production was detected by using an HIV p24 antigen ELISA assay in blood mononuclear cells in 54% of asymptomatic, 71% of acquired immunodeficiency syndrome (AIDS)-related complex, and 100% of
McArthur JC; Sipos E; Cornblath DR; Welch D; Chupp M; Griffin DE; Johnson RT; Department of Neurology, Johns Hopkins University School of; Medicine, Baltimore, MD.
Using immunocytochemical methods, CSF lymphocyte subpopulations were examined in different neurologic disorders associated with human immunodeficiency virus (HIV) infection. CSF pleocytosis was observed in asymptomatic neurologically normal subjects, in patients with aseptic meningitis, and those with inflammatory dem
Am J Med. 1989 Jan;86(1):65-70. Unique Identifier : AIDSLINE MED/89086467
deShazo RD; Chadha N; Morgan JE; Shorty VJ; Rangan SR; Kalyanaraman VS; Hyslop N; Chapman Y; O'Dea S; Tulane/Louisiana State University AIDS Clinical Trials Group, New; Orleans.
PURPOSE: Although clusters of individuals infected with the human T-cell lymphotrophic virus type I (HTLV-I) have been identified in the United States , no systematic evaluation of the immunologic status of these persons has been reported. We therefore studied a group of 11 HTLV-I-infec
Am Heart J. 1989 Jan;117(1):140-4. Unique Identifier : AIDSLINE MED/89103098
Stewart JM; Kaul A; Gromisch DS; Reyes E; Woolf PK; Gowitz MH; Department of Pediatrics, New York Medical College, Valhalla; 10595.
Eight children with human immunodeficiency virus (HIV) infection had symptomatic cardiac dysfunction. The median age was 1.4 years (range 0.2 to 7.9 years). All had hepatosplenomegaly, fever, pneumonia with tachypnea, and tachycardia ascribed to infection and anemia. An S3 gallop was present in six of eight. All had n
J Immunol. 1989 Jan 1;142(1):274-82. Unique Identifier : AIDSLINE GENBANK/M23442
Arai N; Nomura D; Villaret D; DeWaal Malefijt R; Seiki M; Yoshida M; Minoshima S; Fukuyama R; Maekawa M; Kudoh J; et al; Department of Molecular Biology, DNAX Research Institute, Palo; Alto, CA 94304-1104.
We have isolated a chromosomal DNA segment of the human IL-4 gene based on homology with a human IL-4 cDNA sequence and determined its complete nucleotide sequence. The human IL-4 gene, which occurs as a single copy in the haploid genome, is mapped on chromosome 5. It is composed of four exons and three introns and is
Jabs DA; Enger C; Bartlett JG; Wilmer Ophthalmological Institute, Department of Ophthalmology,; Johns Hopkins University School of Medicine, Baltimore, MD 21205.
In a series of 157 patients with acquired immunodeficiency syndrome (AIDS), 46 (29%) developed cytomegalovirus ( CMV ) retinitis. In five patients, CMV retinitis was the initial AIDS-defining opportunistic infection (11% of pat
Brouillette DE; Alexander J; Yoo YK; Chien MC; Tarter RE; Gavaler J; Van Thiel DH; University of Pittsburgh, School of Medicine, Pennsylvania.
Individuals undergoing hepatic and renal transplants are susceptible to infections of the gastrointestinal tract, particularly the esophagus. The most common responsible agents are Candida and herpes simplex virus (HSV) with cytomegalovirus (
Int J Cancer. 1989 Jan 15;43(1):72-9. Unique Identifier : AIDSLINE MED/89092485
Henderson EE; Franks C; Fronko G; Department of Microbiology and Immunology, Temple University; School of Medicine, Philadelphia, PA 19140.
When treated with chemical carcinogens, peripheral blood lymphocytes (PBLs) from normal adults or patients with acquired immunodeficiency syndrome (AIDS) were more readily transformed than non-treated PBLs into immortalized lymphoblastoid cell lines (LCLs) by the Epstein-Barr virus (EBV, FF41-1). Chemical carcinogens
J Immunol. 1989 Jan 15;142(2):702-7. Unique Identifier : AIDSLINE MED/89093961
Tong-Starkesen SE; Luciw PA; Peterlin BM; Howard Hughes Medical Institute, Department of Medicine, San; Francisco, CA 94143.
The state of T cell activation and proliferation controls HIV-1 replication and gene expression. Previously, we demonstrated that the administration of PHA and PMA to the human T cell line Jurkat activates the HIV-1 enhancer, which is composed of two nuclear factor kappa B (NF kappa B) binding sites. Here, we show tha
Gius D; Laimins LA; Department of Molecular Genetics and Cell Biology, University of; Chicago, Illinois 60637.
Several viral trans-activators and a tumor promoter were examined for the ability to activate human papillomavirus type 18 (HPV-18) gene expression. A plasmid containing the HPV-18 noncoding region placed upstream of the chloramphenicol acetyltransferase reporter gene was cotransfected with different herpes simplex vi
Koup RA; Sullivan JL; Levine PH; Brewster F; Mahr A; Mazzara G; McKenzie S; Panicali D; Department of Pediatrics and Medicine, University of; Massachusetts Medical School, Worcester 01655.
Antibody-dependent cell-mediated cytotoxicity (ADCC) specific for human immunodeficiency virus (HIV) has been described for HIV-infected individuals. To determine the antigenic specificity of this immune response and to define its relationship to the disease state, an ADCC assay was developed using Epstein-Barr virus-
Fennie C; Lasky LA; Department of Molecular Immunology, Genentech, Inc., South San; Francisco, California 94080.
The intracellular folding of the human immunodeficiency virus type 1 gp120 has been assessed by analyzing the ability of the glycoprotein to bind to the viral receptor CD4. Pulse-chase experiments revealed that the glycoprotein was initially produced in a conformation that was unable to bind to CD4 and that the protei
Owens RJ; Compans RW; Department of Microbiology, University of Alabama, Birmingham; 35294.
Polarized epithelial cells exhibit apical (lumenal) and basolateral (serosal) membrane domains that are separated by circumferential tight junctions. In such cells, enveloped viruses that mature by budding at cell surfaces are released at particular membrane domains. We have used a vaccinia virus recombinant to invest
JAMA. 1989 Feb 3;261(5):719-24. Unique Identifier : AIDSLINE MED/89095114
Kaplan LD; Abrams DI; Feigal E; McGrath M; Kahn J; Neville P; Ziegler J; Volberding PA; Department of Medicine, San Francisco General Hospital, CA 94110.
The characteristics of acquired immunodeficiency syndrome-associated non-Hodgkin s lymphoma in 84 patients diagnosed and treated at San Francisco General Hospital are presented herein. While the majority were high-grade B-cell lymphomas, one cutaneous T-cell and one peripheral T-ce
N Engl J Med. 1989 Feb 2;320(5):289-93. Unique Identifier : AIDSLINE MED/89097151
Erice A; Chou S; Biron KK; Stanat SC; Balfour HH Jr; Jordan MC; Department of Laboratory Medicine and Pathology, University of; Minnesota Health Sciences Center, Minneapolis.
N Engl J Med. 1989 Feb 2;320(5):293-6. Unique Identifier : AIDSLINE MED/89097152
Erlich KS; Mills J; Chatis P; Mertz GJ; Busch DF; Follansbee SE; Grant RM; Crumpacker CS; Department of Medicine, University of California, San Francisco.
Nature. 1989 Jan 19;337(6204):267-70. Unique Identifier : AIDSLINE MED/89097275
Watanabe M; Reimann KA; DeLong PA; Liu T; Fisher RA; Letvin NL; Harvard Medical School, New England Regional Primate Research; Center, Southborough, Massachusetts 01772.
The CD4 molecule is a high-affinity cell-surface receptor for the human immunodeficiency virus (HIV-1) and a soluble truncated form of CD4 produced by recombinant DNA technology is a potent inhibitor of HIV-1 replication and HIV-1-induced cell fusion in vitro. Rhesus monkeys infected with the simian immunodeficiency v
Nature. 1989 Jan 26;337(6205):368-70. Unique Identifier : AIDSLINE MED/89097308
Clapham PR; Weber JN; Whitby D; McIntosh K; Dalgleish AG; Maddon PJ; Deen KC; Sweet RW; Weiss RA; Chester Beatty Laboratories, Institute of Cancer Research,; London, UK.
The CD4 antigen has been subverted as a receptor by the human and simian immunodeficiency viruses (HIV-1, HIV-2 and SIV). Several groups have reported that recombinant, soluble forms of the CD4 molecule (sCD4) block the infection of T lymphocytes by HIV-1, as CD4 binds the HIV envelope glycoprotein, gp120, with high a
Proc Natl Acad Sci U S A. 1989 Jan;86(2):414-8. Unique Identifier : AIDSLINE GENBANK/M23048
Davis JL; Clements JE; Department of Neurology, Johns Hopkins University School of; Medicine, Baltimore, MD 21205.
The unique pathogenesis of lentiviral infections in humans and ruminant animals may be explained, in part, by the complex mechanisms regulating transcription and translation of their viral genes. This report demonstrates that a visna virus-encoded protein transactivates viral gene expression. A 1.4-kilobase cDNA clone
Proc Natl Acad Sci U S A. 1989 Jan;86(2):621-5. Unique Identifier : AIDSLINE MED/89098982
Wahl LM; Corcoran ML; Pyle SW; Arthur LO; Harel-Bellan A; Farrar WL; Cellular Immunology Section, National Institute of Dental; Research, Bethesda, MD 20892.
This study reports on the direct effect of the envelope glycoprotein (gp120) of the human immunodeficiency virus type 1 (HIV-1) on human monocyte function. Addition of preparations of purified gp120 from the HIV-1 to human monocytes resulted in the production of interleukin 1 (IL-1) and arachidonic acid metabolites fr
Science. 1989 Jan 27;243(4890):529-33. Unique Identifier : AIDSLINE GENBANK/M22461
Reddy EP; Sandberg-Wollheim M; Mettus RV; Ray PE; DeFreitas E; Koprowski H; Wistar Institute of Anatomy and Biology, Philadelphia, PA 19104.
Techniques of gene amplification, molecular cloning, and sequence analysis were used to test for the presence of sequences related to human T-lymphotropic virus type I (HTLV-I) in peripheral blood mononuclear cells of six patients with multiple sclerosis (MS) and 20 normal individuals. HTLV-I sequences were detected i
Ann Intern Med. 1989 Feb 1;110(3):189-94. Unique Identifier : AIDSLINE MED/89104120
Merigan TC; Skowron G; Bozzette SA; Richman D; Uttamchandani R; Fischl M; Schooley R; Hirsch M; Soo W; Pettinelli C; et al; Stanford University School of Medicine, California.
STUDY OBJECTIVE: To determine the safety and efficacy of dideoxycytidine in patients with the acquired immunodeficiency syndrome (AIDS) or advanced AIDS-related complex. DESIGN: A partially randomized phase I and II outpatient, dose-ranging study. SETTING: Four university medical centers involving government-supported
Ann Intern Med. 1989 Feb 1;110(3):239-41. Unique Identifier : AIDSLINE MED/89104127
Lee JW; Fox EP; Rodgers-Johnson P; Gibbs CJ Jr; DeFreitas E; Manns A; Blattner W; Cotelingam J; Piccardo P; Mora C; et al; National Cancer Institute, Bethesda, Maryland.
Lancet. 1989 Jan 14;1(8629):65-8. Unique Identifier : AIDSLINE MED/89082168
Hampson SJ; Portaels F; Thompson J; Green EP; Moss MT; Hermon-Taylor J; McFadden JJ; Department of Surgery, St George's Hospital Medical School,; London.
Strains of the Mycobacterium avium intracellulare complex (MAIC) have become important colonisers of patients with acquired immunodeficiency syndrome (AIDS). Restriction fragment length polymorphisms were used to study the DNA from 88 MAIC isolates, including 51 derived from 47 AIDS patients. MAIC isolates from 33 of
Can Med Assoc J. 1989 Jan 15;140(2):125-8. Unique Identifier : AIDSLINE MED/89089466
Neumann PW; O'Shaughnessy MV; Lepine D; D'Souza I; Major C; McLaughlin B; Bureau of Laboratories Services, Federal Centre for AIDS, Ottawa,; Ont.
Until recently the geographic distribution of infection due to human immunodeficiency virus type 2 (HIV-2) had excluded North America. We report the first two cases of such infection in Canada . Both people came from endemic areas of western Africa and were asymptomatic. The results
Romagnani S; Del Prete G; Maggi E; Parronchi P; Tiri A; Macchia D; Giudizi MG; Almerigogna F; Ricci M; Allergology and Clinical Immunology, University of Florence,; Firenze, Italy.
Studies of human IgE synthesis are summarized and provide further insight into the cellular and molecular mechanisms involved in IgE regulation, as well as in the alterations responsible for IgE disregulation in some pathological conditions. These include the demonstration that IL-4 is the essential factor for the ind
Rosenberg ZF; Fauci AS; National Institute of Allergy and Infectious Diseases, Bethesda,; Maryland 20892.
The acquired immunodeficiency syndrome (AIDS) follows infection with the human immunodeficiency virus (HIV) after a long and variable period of time. Although HIV can be rapidly cytopathic in vitro for T4 cells, during early in vivo infection, T4 cell numbers are normal and few infected T4 cells can be found. There is
Galli M; Lazzarin A; Saracco A; Balotta C; Castagna A; Negri C; Ridolfo AL; Uberti-Foppa C; Corbellino M; Moroni M; Clinic of Infectious Disease, University of Milan, Italy.
Intravenous drug users (IVDUs) account for more than 64% of the total AIDS cases in Italy . The IVDUs seropositivity rate is greater than 70% in Milan and greater than 50% in the main cities of Italy. The first evidence of seropositivity in this population dates back to 1979. In a c
FASEB J. 1989 Jan;3(1):22-30. Unique Identifier : AIDSLINE MED/89091855
Edelman AS; Zolla-Pazner S; Laboratory Service, New York Veterans Administration Medical; Center, New York 10010.
Acquired immune deficiency syndrome (AIDS) is a disease caused by the human immunodeficiency virus (HIV) in which cellular immune functions are severely impaired. Acute infection and subsequent destruction of helper T cells, although occurring readily in cell cultures, do not appear to be the only mechanisms mediating
Tanese N; Prasad VR; Goff SP; Department of Biochemistry and Molecular Biophysics, Columbia; University, College of Physicians and Surgeons, New York, NY; 10032.
A collection of variant plasmids that express the human immunodeficiency virus (HIV) reverse transcriptase as trpE fusion proteins were generated and scored for their ability to produce stable, active proteins. Trimming portions of the viral pol gene resulted in dramatic increases in yield over earlier constructs; the
FEBS Lett. 1988 Dec 19;242(1):9-21. Unique Identifier : AIDSLINE MED/89078628
Zvelebil MJ; Sternberg MJ; Cookson J; Coates AR; Department of Crystallography, Birkbeck College, London, England.
An important consideration in the design of vaccines to prevent HIV-1 infection effective against different strains is the amino acid sequence conservation of antigenic determinants. Even one amino acid change can destroy the antigenicity of a site for the antibody or T-cell receptor. The comparisons of predicted T- a
The first phase in the history of the chemotherapy of infection by HIV has been completed. An effective compound, AZT , has been identified that prolongs life and reduces morbidity. The next phase will be to determine the most effective and least toxic
Kulaga H; Folks T; Rutledge R; Truckenmiller ME; Gugel E; Kindt TJ; Laboratory of Immunogenetics, National Institute of Allergy and; Infectious Disease, Bethesda, Maryland 20892.
Injection of rabbits with a human T cell line infected with HIV-1 caused seroconversion within 6 wk, and HIV-1 could be isolated from PBL cultures of infected rabbits. Identity of the isolated virus with HIV-1 was shown by analysis of products amplified by the polymerase chain reaction. HIV-1 infection was seen in rab
J Med Virol. 1988 Nov;26(3):261-70. Unique Identifier : AIDSLINE MED/89080550
Krone WJ; Debouck C; Epstein LG; Heutink P; Meloen R; Goudsmit J; Virology Department, University of Amsterdam, The Netherlands.
The tat regulatory protein of HIV-1 was expressed as a fusion protein in E. coli and used as antigen to detect antibodies against HIV-tat (anti-tat) in the serum of HIV-1 infected children and adults. HIV-1-infected children showed a higher frequency (55%) of anti-tat than HIV-1-infected adults (36%). Anti-tat were pr
Chang RS; Tabba HD; He YS; Smith KM; Department of Medical Microbiology and Immunology, University of; California, Davis 95616.
Dextran sulfate (DS) is a potent inhibitor of the growth of human immunodeficiency virus type 1 (HIV-1) in the H9 cell. Its minimal inhibitory concentration is about 1 microgram/ml. Its therapeutic index is greater than or equal to 200 which is higher than that of 38 for zidovudine. At the ID100 range, DS blocks the s
Groopman JE; Department of Medicine, New England Deaconess Hospital, Boston,; MA 02215.
The colony-stimulating factors (CSFs) are polypeptide hormones that regulate myeloid proliferation and differentiation. Granulocyte-macrophage CSF (GM-CSF) has been used in leukopenic acquired immunodeficiency syndrome (AIDS) patients, myelodysplastic syndrome patients, and cancer patients after intensive chemotherapy
Figlin RA; Department of Medicine, UCLA School of Medicine 90024.
In the past decade, interferon, the first of a new class of biologic response modifiers, has undergone extensive Phase I and II clinical evaluation in a broad spectrum of cancers, including hematologic malignancies, lymphomas, and solid tumors. Interferon has been found to have important clinical activity in hairy-cel
Am J Epidemiol. 1989 Jan;129(1):138-45. Unique Identifier : AIDSLINE MED/89086381
Dusheiko GM; Brink BA; Conradie JD; Marimuthu T; Sher R; Academic Department of Medicine, Royal Free Hospital, Hampstead,; London, United Kingdom.
Although hepatitis B infection is endemic in southern Africa, a changing epidemiology of the disease has recently been documented in the region. The authors surveyed migrant southern African male mineworkers during 1986 to establish the prevalence of chronic hepatitis B and D (delta) infection in their areas of origin
Recombination between HIV DNAs was analyzed using DNA transfection in cell cultures and the optimal conditions for efficient recombination were determined. Recombinant plasmid DNA substrates were constructed from HIV proviral DNAs and the success of recombination was measured by the production of viable hybrid virus.
Biochem Pharmacol. 1989 Jan 1;38(1):109-19. Unique Identifier : AIDSLINE MED/89087496
Bazin H; Chattopadhyaya J; Datema R; Ericson AC; Gilljam G; Johansson NG; Hansen J; Koshida R; Moelling K; Oberg B; et al; Department of Bioorganic Chemistry, University of Uppsala,; Sweden.
Some 3 -blocked pyrimidine analogs were synthesized and tested as inhibitors of replication of human immunodeficiency virus (HIV) and Moloney-murine leukemia virus (MuLV). The analogs were of 3 kinds: (1) analogs of 3 -azido-3 -deoxythymidine ( AZT ) in
AIDS Res Hum Retroviruses. 1988 Aug;4(4):259-67. Unique Identifier : AIDSLINE MED/89087764
Ahearne PM; Matthews TJ; Lyerly HK; White GC; Bolognesi DP; Weinhold KJ; Department of Surgery, Duke University Medical Center, Durham, NC; 27710.
In efforts to identify B cell and T cell epitopes of HIV-1 structural components, serum as well as lymphocytes from HIV-1-seropositive individuals were reacted with several recombinant and native peptides representing defined viral gag and env determinants. Several areas of discordance between humoral and cellular rea
Watari K; Asano S; Shirafuji N; Kodo H; Ozawa K; Takaku F; Kamachi S; Department of Hematology-Oncology, Institute of Medical Science,; University of Tokyo, Japan.
In order to better understand the patho-physiologic role of granulocyte colony-stimulating factor (G-CSF), we estimated its serum levels in healthy persons and patients with various disorders, using a newly developed enzyme immunoassay (Motojima et al). In 49 of 56 normal healthy persons (88%), the levels were beneath
Avendano C; Rausell E; Perez-Aguilar D; Isorna S; Department of Morphology, Faculty of Medicine, Autonoma; University, Madrid, Spain.
The association (intrahemispheric) cortico-cortical afferent connections of area 5 were studied in the cat by means of retrograde tracing techniques involving horseradish peroxidase (HRP) free or wheat germ agglutinin-conjugated (WGA-HRP) or fluorochrome injections. Single or multiple injections were placed in differe
J Immunol. 1989 Jan 15;142(2):431-8. Unique Identifier : AIDSLINE MED/89093923
Clouse KA; Powell D; Washington I; Poli G; Strebel K; Farrar W; Barstad P; Kovacs J; Fauci AS; Folks TM; Georgetown University, Department of Microbiology, Washington,; D.C. 20007.
A T cell clone (ACH-2) derived from T cells infected with HIV-1 was found to produce HIV-1 in response to stimulation with a monokine-enriched supernatant prepared by culturing human monocyte/macrophages with bacterial LPS (LPS-MO SN). Monokine induction of ACH-2 cells resulted in augmented virus production reflected
J Immunol. 1989 Jan 15;142(2):452-62. Unique Identifier : AIDSLINE MED/89093926
Hoffenbach A; Langlade-Demoyen P; Dadaglio G; Vilmer E; Michel F; Mayaud C; Autran B; Plata F; Laboratoire de Biologie et d'Immunologie Moleculaires des; Retrovirus, Institut Pasteur, Paris, France.
CTL specific for the HIV belong to the CD8 subset of T lymphocytes, and their activity is restricted by class I HLA transplantation Ag. In this report, HIV-specific CTL and their precursor cells were quantified by limiting dilution analysis. CTL were recovered from the lungs, lymph nodes, and blood of asymptomatic ser
A double staining technique for simultaneously determinating cell surface phenotype and the degree of cell activation is described. As an activation marker, the tetrazolium dye MTT has been used. Cells were incubated for 30 min with MTT. Activated cells yielded a granular staining pattern. Upon termination of the reac
Dopel SH; Porstmann T; Grunow R; Jungbauer A; Von Baehr R; Department of Medicine (Charite), Humboldt University Berlin,; G.D.R.
The ELISA is the established screening technique for the detection of antibodies directed against HIV. The first generation assays, mostly based on the sandwich principle, employed purified virus from cell culture and gave both false-positive and false-negative results. Sandwich-type assays preferentially detect IgG a
von Ruden T; Gilboa E; Institute of Genetics, Johannes Gutenberg University of Mainz,; Federal Republic of Germany.
The human T-cell leukemia virus type I is associated with adult T-cell leukemia-lymphoma in humans, a disease which is induced by a malignant transformation of T lymphocytes. Retrovirus vectors carrying human T-cell leukemia virus type I-derived sequences in reversed transcriptional orientation were used to express an
Nature. 1989 Jan 26;337(6205):370-3. Unique Identifier : AIDSLINE MED/89097309
Lusso P; Ensoli B; Markham PD; Ablashi DV; Salahuddin SZ; Tschachler E; Wong-Staal F; Gallo RC; Laboratory of Tumor Cell Biology, National Cancer Institute,; Bethesda, Maryland 20892.
Although infection by HIV-1 has been implicated as the primary cause of AIDS and related disorders, cofactorial mechanisms may be involved in the pathogenesis of the disease. For example, several viruses commonly detected in AIDS patients and capable of transactivating the long terminal repeat of HIV-1, such as herpes
Ann Intern Med. 1989 Feb 1;110(3):183-8. Unique Identifier : AIDSLINE MED/89104119
Abrams DI; Kuno S; Wong R; Jeffords K; Nash M; Molaghan JB; Gorter R; Ueno R; University of California, San Francisco.
STUDY OBJECTIVE: To evaluate the tolerance and safety of oral dextran sulfate (UA001), a potent in-vitro inhibitor of human immunodeficiency virus (HIV) in patients with the acquired immunodeficiency syndrome (AIDS) and AIDS-related complex. DESIGN: Unblinded, dose-escalation 8-week trial. SETTING: An AIDS outpatient
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