Control of gene expression and the replication and pathogenesis of retroviruses. NLM AIDSLINE Important note: Information in this article was accurate in 1988. The state of the art may have changed since the publication date.

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Control of gene expression and the replication and pathogenesis of retroviruses.

Important Adv Oncol. 1986;:159-72. Unique Identifier : AIDSLINE MED/88243222
Haseltine WA; Sodroski J; Rosen CA

Abstract: The replicative pathways, modes of transmission, and pathobiology of retroviruses depend upon an interplay between mechanisms that control host gene expression and the expression of virus gene products. The nonacute transforming viruses that contain only the gag, pol, and env genes are dependent upon host gene trans-acting transcription factors for replication and expression. The host cell trans-acting factors vary according to cell type. For this reason, the tissue tropism and pathogenesis of these viruses depend upon the compatibility of cis-acting viral regulatory elements with the host trans-acting factors. Such interactions play a dominant role in determining tissue-specific tumor induction of murine retroviruses. Recently a group of retroviruses that induce trans-acting regulatory factors has been identified. The group includes etiologic agents of ATLL and AIDS. Compatibility between the virally encoded trans-acting gene regulatory factors and cis-acting regulatory elements of differentiated cells may play the dominant role in determining the tissue specificity and pathogenic effect of these viruses.
Keywords: *Gene Expression Regulation Genes, Viral Human Retroviridae/*GENETICS/PATHOGENICITY *Virus Replication JOURNAL ARTICLE REVIEW REVIEW, ACADEMIC

KWDgeneexpressionregulationgenes,viralhumanretroviridae/KWDgenetics/pathogenicityKWDvirusreplicationjournalarticlereviewreview,academic
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M8890529

Copyright © 1988 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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