Lack of evidence of prolonged human immunodeficiency virus infection before antibody seroconversion. NLM AIDSLINE Important note: Information in this article was accurate in 1988. The state of the art may have changed since the publication date.

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Lack of evidence of prolonged human immunodeficiency virus infection before antibody seroconversion.

Blood. 1988 Jun;71(6):1752-4. Unique Identifier : AIDSLINE MED/88222417
Groopman JE; Caiazzo T; Thomas MA; Ferriani RA; Saltzman S; Moon M; Seage G; Horsburgh CR Jr; Mayer K; Department of Medicine, New England Deaconess Hospital/Harvard; Medical School, Boston, MA.

Abstract: Recently, considerable concern has been raised regarding the possibility that antibody-based screening tests for the human immunodeficiency virus (HIV) may fail to detect certain high-risk individuals for prolonged periods of time. It has been proposed that testing for HIV-related antigen may be a necessary procedure to detect such individuals. To address this issue, we longitudinally studied two groups of homosexual men: direct sexual partners of acquired immunodeficiency syndrome (AIDS) or AIDS-related complex (ARC) patients and individuals who ultimately sero-converted. There was no evidence of prolonged infection with HIV in the absence of detectable antibody in these two groups. It appears at this time that, even among subjects at very high risk for HIV infection, currently available antibody-based assays are sufficient to identify infected individuals.
Keywords: Acquired Immunodeficiency Syndrome/*IMMUNOLOGY Antibodies, Viral/ANALYSIS HIV Seropositivity/*IMMUNOLOGY Support, Non-U.S. Gov't Support, U.S. Gov't, Non-P.H.S. Support, U.S. Gov't, P.H.S. Time Factors Viral Core Proteins/IMMUNOLOGY Viral Envelope Proteins/IMMUNOLOGY JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/KWDimmunologyantibodies,viral/analysishivseropositivity/KWDimmunologysupport,non-uKWDsKWDgov'tsupport,uKWDsKWDgov't,non-pKWDhKWDsKWDsupport,uKWDsKWDgov't,pKWDhKWDsKWDtimefactorsviralcoreproteins/immunologyviralenvelopeproteins/immunologyjournalarticle
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M8890523

Copyright © 1988 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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