Chicago, Ill. (535 N. Dearborn St., Chicago 60610) : American Medical Association, [c1987] 24, 24, 24 p. : ill Unique Identifier : AIDSLINE CAT/8807611
[Rockville, Md.?] : U.S. Dept. of Health & Human Services, Public Health Service, [1987?] x, 102 p. : ill (DHHS publication ; HRS-D-MC 87-1) Unique Identifier : AIDSLINE CAT/8807775
Silverman BK; Waddell A; Division of Maternal and Child Health; Their Families
Oxford ; Boston : Blackwell Scientific Publications ; Chicago, Ill. : Distributors USA, Year Book Medical Publishers, 1989 xi, 331 p Unique Identifier : AIDSLINE CAT/8807288
Dev Oncol; 52:227-91 1987. Unique Identifier : AIDSLINE ICDB/88645095
Anonymous; No affiliation given
Part V of Brain Oncology. Biology, Diagnosis and Therapy, a book that is based on papers presented at the International Meeting on Brain Oncology, held in Rennes, France , on September 4-5, 1986, consists of articles having the following titles: multicenter epidemiological study o
Ann Intern Med; 107(5):I145-57 1987. Unique Identifier : AIDSLINE ICDB/88645297
Anonymous; No affiliation given
Precautions to be exercised in the prevention of transmission of human immunodeficiency virus (HIV), as excerpted from Morbidity and Mortality Weekly Report (MMWR 36:3S-18S, 1987), are presented under the following headings: universal precautions, precautions for invasive procedures, precautions for dentistry, precaut
Ginn DS; Louis Calder Memorial Library, University of Miami School of; Medicine, Florida 33136.
The dramatic increase in the number of cases and deaths from AIDS since 1981 has been accompanied by an information explosion on the topic. The government, health professionals, service organizations, consumers, and the media are each vital links in both formal and informal AIDS information networks. New information s
Three cases of thrombocytopenia in pregnant women are described. Two of these patients had an AIDS-like illness and the third one had AIDS. This HIV-associated change occurred in 8% of the complications of a consecutive series of 38 pregnant women who were positive for the HIV antibody test in the course of one year.
Friedman SR; Sotheran JL; Abdul-Quader A; Primm BJ; Des Jarlais DC; Kleinman P; Mauge C; Goldsmith DS; el-Sadr W; Maslansky R; Narcotic and Drug Research, Inc., New York, NY 10013.
Social researchers and epidemiologists, as well as their major institutions and the general public, have been slow to address the racial and ethnic aspects of the AIDS epidemic. Whether measured by categories associated with major routes of infection, age level, gender, or by diminished length of survival, blacks and
Postgrad Med J. 1987 Dec;63(746):1103-4. Unique Identifier : AIDSLINE MED/88234286
Connolly GM; Gazzard BG; St. Stephen's Hospital, London, UK.
A 33 year old man with acquired immunodeficiency syndrome developed a toxic megacolon. The patient was admitted with a two month history of diarrhoea. Cryptosporidia were isolated from all stool specimens. Clinically and radiographically he developed toxic dilatation of the colon which responded to conservative manage
De Clercq E; Sakuma T; Baba M; Pauwels R; Balzarini J; Rosenberg I; Holy A; Rega Institute for Medical Research, Katholieke Universiteit; Leuven, Belgium.
Various 3-hydroxy-2-phosphonylmethoxypropyl (HPMP) and 2-phosphonylmethoxyethyl (PME) derivatives of purine [adenine (A), guanine (G), 2,6-diaminopurine (DAP), 2-monoaminopurine (MAP), hypoxanthine (HX)] and pyrimidine [cytosine (C), uracil (U), thymine (T)] have been evaluated for their antiviral properties. PMEDAP,
Am J Physiol Imaging. 1986;1(3):134-41. Unique Identifier : AIDSLINE MED/88240741
Gill PS; Graham RA; Boswell W; Meyer P; Krailo M; Levine AM; Department of Medicine, University of Southern California School; of Medicine, Los Angeles 90033.
Patients with acquired immune deficiency syndrome (AIDS) often have central nervous system mass lesions. Since clinical signs, symptoms, and results of imaging techniques are generally nonspecific, brain biopsy has been considered to be the optimal method for establishing a definitive diagnosis. In an effort to define
Carbone A; Poletti A; Manconi R; Cozzi M; Sulfaro S; Volpe R; Divisione di Anatomia Patologica, Centro di Riferimento; Oncologico, Aviano, Italy.
We used a panel of monoclonal and polyclonal antibodies to analyze frozen and paraffin-embedded lymph node biopsy specimens from 25 intravenous drug abusers (IVDA) with acquired immunodeficiency syndrome (AIDS)-related lymphadenopathy histologically characterized by follicular hyperplasia. Our aim was to obtain diagno
A case of transfusion-related AIDS is described which is believed to be the first published case to occur in New Zealand in a nonhaemophiliac patient. The human immunodeficiency virus (HIV) positive donor was shown to be the source of infection in five further HIV positive reci
Am J Law Med. 1986;12(3-4):381-403. Unique Identifier : AIDSLINE MED/88238573
Grad FP; Legislative Drafting Research Fund, Columbia University School of; Law.
Laws for the protection of public health control either the environment, as in the case of sanitation or air pollution regulations, or human conduct. This Article deals with limitations imposed upon individuals in order to prevent the spread of communicable disease and the harm resulting from mental illness. The restr
Derouin F; Sulcebe G; Ballet JJ; Laboratoire de Parasitologie-Mycologie, Hopital Saint-Louis,; Paris, France.
During the course of T. gondii infection, we have analysed serum IgG and IgA antibodies responses in 50 immunocompetent with acquired infection and 19 immunocompromised patients with evidence of reactivated toxoplasmosis. Using an ELISA, IgG1, IgG2, IgG3 and IgA antibodies were found in sera of all patients, whereas I
Important Adv Oncol. 1986;:159-72. Unique Identifier : AIDSLINE MED/88243222
Haseltine WA; Sodroski J; Rosen CA
The replicative pathways, modes of transmission, and pathobiology of retroviruses depend upon an interplay between mechanisms that control host gene expression and the expression of virus gene products. The nonacute transforming viruses that contain only the gag, pol, and env genes are dependent upon host gene trans-a
Groopman JE; Caiazzo T; Thomas MA; Ferriani RA; Saltzman S; Moon M; Seage G; Horsburgh CR Jr; Mayer K; Department of Medicine, New England Deaconess Hospital/Harvard; Medical School, Boston, MA.
Recently, considerable concern has been raised regarding the possibility that antibody-based screening tests for the human immunodeficiency virus (HIV) may fail to detect certain high-risk individuals for prolonged periods of time. It has been proposed that testing for HIV-related antigen may be a necessary procedure
Can Med Assoc J. 1988 Jun 1;138(11):1013-5. Unique Identifier : AIDSLINE MED/88223051
Pollard DR; Gill P; Day A; Bureau of Microbiology, Department of National Health and; Welfare, Ottawa, Tunney's Pasture, Ont.
We wished to compare the frequency of group-specific (Gc) phenotypes in the general population with that in people with human immunodeficiency virus (HIV) infection to find out whether the Gc protein is a marker for susceptibility to HIV infection. We determined the phenotype frequency in 1083 randomly selected serum
Dean NC; Golden JA; Evans LA; Warnock ML; Addison TE; Hopewell PC; Levy JA; Medical Service, San Francisco General Hospital Medical Center.
We cultured bronchoalveolar lavage fluid for the human immunodeficiency virus (HIV) from 23 consecutive patients with acquired immunodeficiency syndrome (AIDS) and pulmonary symptoms. We also included a nonconsecutive AIDS patient with recent worsening of respiratory symptoms who had had lymphocytic interstitial pneum
Dtsch Med Wochenschr. 1988 May 20;113(20):815-8. Unique Identifier : AIDSLINE MED/88224666
Spehn J; Jenzevski H; Pulz M; Emskotter T; Medizinische Kernklinik und Poliklinik, Institut fur; Medizinische Mikrobiologie und Immunologie, Universitat Hamburg.
Ten years after treatment of secondary syphilis a 44-year-old otherwise asymptomatic HIV-infected patient developed acute meningovascular syphilis with multifocal manifestations and neurological deficit. Whether it was a reactivation or new infection could not be established. High-dosage intravenous penicillin treatme
Diederich N; Ackermann R; Jurgens R; Ortseifen M; Thun F; Schneider M; Vukadinovic I; Universitats-Nervenklinik Koln, Schwerpunkt Neurologie, FRG.
We report on 79 patients of different stages of human immune deficiency virus (HIV) infection according to the Walter-Reed staging classification (WR). Comparing the HIV antibody content per weight IgG in serum and cerebrospinal fluid (CSF), 54 patients (68%) showed higher antibody activity in CSF than in serum, indic
Meiselman MS; Miller-Catchpole R; Christ M; Randall E; Department of Medicine, Evanston Hospital, Illinois.
Campylobacter pylori has been associated with gastritis, duodenitis, and duodenal ulceration in the immunocompetent individual. It has been described within the superficial mucus layer, in interepithelial junctions, and occasionally in the microcanaliculi of epithelial cells, but never in the lamina propria. We descri
Phillips M; Cummins LM; Division of Clinical Pharmacology, Chicago Medical School,; Illinois 60064.
Recent studies have demonstrated that commercial preparations of hepatitis B immune globulin often contain antibody to the human immunodeficiency virus. The presence of this antibody has aroused concerns that treatment with hepatitis B immune globulin might passively induce human immunodeficiency virus antibody seropo
O'Hara CJ; Groopman JE; Federman M; Department of Pathology, England Deaconess Hospital, Harvard; Medical School, Boston, MA 02215.
Viral particles have been demonstrated by electron microscopy in lymph nodes from patients with acquired immune deficiency syndrome AIDS-related persistent generalized lymphadenopathy (PGL) syndrome. Immunohistochemical and in situ hybridization studies have identified these viruses as the human immunodeficiency virus
Green MS; Karsenty E; Slater PE; Medical Corps, Israel Defense Forces, Jerusalem.
The effect of the AIDS pandemic on the sexual behavior of the general population has not been clearly established. Since trends in the incidence of other sexually transmitted diseases may be a good marker of such behavioral changes, gonorrhea incidence in the civilian and military populations in
Lepage P; Van de Perre P; Department of Pediatrics, Centre Hospitalier de Kigali, Rwanda.
We reviewed the published data on the possible impact of medical injections and blood transfusions on the spread of human immunodeficiency virus (HIV) in Africa. We also compared these results to our experience in Rwanda , central Africa. The importance of medical injections in the
Nature. 1988 Jun 2;333(6172):457-61. Unique Identifier : AIDSLINE GENBANK/X07805
Fukasawa M; Miura T; Hasegawa A; Morikawa S; Tsujimoto H; Miki K; Kitamura T; Hayami M; Department of Animal Pathology, University of Tokyo, Japan.
Some wild African green monkeys are known to be naturally infected with a retrovirus related to human immunodeficiency virus (HIV) without having any apparent symptoms of an AIDS-like disease. This simian immunodeficiency virus, designated SIVAGM, may be helpful in clarifying the evolution and pathogenicity of HIV. So
Nature. 1988 Jun 9;333(6173):511-2. Unique Identifier : AIDSLINE MED/88232928
Layne SP; Marr TG; Colgate SA; Hyman JM; Stanley EA; Theoretical Division, Los Alamos National Laboratory, New Mexico; 87545.
Researchers and public health officials involved in surveying and forecasting the course of the HIV epidemic require complete and unfiltered information from many sources. Governments should respond by establishing national HIV databases.
Nature. 1988 Jun 9;333(6173):513. Unique Identifier : AIDSLINE MED/88232929
Prince AM; Moor-Jankowski J; Eichberg JW; Schellekens H; Mauler RF; Girard M; Goodall J; Lindsley F. Kimball Research Institute, New York Blood Center,; New York 10021.
Pressure is mounting to relax the regulations on importation of chimpanzees for research. Such a policy is unnecessary and would deepen the plight of an already endangered species.
Nature. 1988 Jun 9;333(6173):514-9. Unique Identifier : AIDSLINE MED/88232930
Anderson RM; May RM; Department of Pure and Applied Biology, Imperial College, London; University, UK.
Epidemiological data on the main determinants of the transmission potential of HIV-1 in specific at risk groups in slowly accumulating, but many uncertainties remain.
A standardized examination, including EEG, was performed in 54 cases of HIV infection. The EEGs were analyzed and compared to 30 EEGs of HIV-negative test persons. The visual analyses with respect to basic activity, dysrhythmias, general slowing, foci and alteration of vigilance were performed without any information
612526 blood donations collected by the Central Laboratory of the Swiss Red Cross Blood Transfusion Service between July 1985 and June 1987 were routinely tested for antibodies to HIV.96 donations (82 men, 14 women were anti-HIV positive (0.157%, 1 of 6369 donations). The prevalence of anti-HIV positive donations was
Science. 1988 Jun 10;240(4858):1525-9. Unique Identifier : AIDSLINE MED/88235945
Kong LI; Lee SW; Kappes JC; Parkin JS; Decker D; Hoxie JA; Hahn BH; Shaw GM; Department of Internal Medicine, University of Alabama,; Birmingham 35294.
Clinical and seroepidemiological studies in West Africa indicate that human immunodeficiency virus type 2 (HIV-2) is widespread and associated with immunodeficiency states of variable degree. In this study, an isolate of HIV-2 from a patient in Senegal was molecularly cloned and c
Brennan JE; Severns ML; Kline LM; Epley KM; American Red Cross Product Development Laboratory, Rockville, Md.
A general-purpose laboratory robot was configured to prepare blood samples for the HBsAg and anti-HIV tests. Several issues were studied in order to eliminate problems and optimize the system. These included pipetting accuracy, intersample carryover, reagent interference, splashing and aerosol generation and user-rela
Whyte GS; Canterbury Regional Blood Transfusion Service, New Zealand.
All 367 recipients and 1,385 donations transfused over a 40-day period were traced and compared by sex, age and discharge diagnosis with the 5,955 concurrent discharges from all general and obstetric hospitals in the area. 6% of discharged patients had been transfused. 21% of transfused patients were dead within 1 yea
Gibbels E; Diederich N; Universitats-Nervenklinik, Koln, Federal Republic of Germany.
This is obviously the first report on a case with a spontaneous sensu strictu relapsing variant of human immunodeficiency virus (HIV)-related polyneuropathy. Its manifestation preceded LAS. Intrathecal HIV-antibodies developed between the most severe third and fourth episode. Analysis of sural nerve biopsy was consist
Am J Med. 1988 Jun;84(6):1076-80. Unique Identifier : AIDSLINE MED/88238612
Cohen PR; Beltrani VP; Grossman ME; Department of Dermatology, College of Physicians and Surgeons of; Columbia University, New York, New York 10032.
Herpes zoster virus infections occur in persons with decreased cellular immunity. A 45-year-old man is described who presented with disseminated herpes zoster as the initial manifestation of his human immunodeficiency virus infection. Disseminated herpes zoster virus infections have been reported in human immunodefici
Frangou-Lazaridis M; Clinton M; Goodall GJ; Horecker BL; Department of Biochemistry, Cornell University Medical College,; New York, New York 10021.
A rat spleen cDNA library was screened for clones carrying the cDNAs for prothymosin alpha and parathymosin. Sequence analysis of a clone carrying the entire coding region for prothymosin alpha confirmed and completed the amino acid sequence for this polypeptide and established the number of amino acid residues as 111
Gastric anisakiasis was an incidental finding on gastroscopy of a 48-year-old man known to have AIDS. At that time the patient had been symptom-free, the test having been performed to check on an ulcerative Candida oesophagitis. The Anisakis larva was extracted through the gastroscope and there has been no recurrence.
Int J Health Serv. 1988;18(2):343-56. Unique Identifier : AIDSLINE MED/88243363
Alvarez Lajonchere C; Department of Health Policy and Management, Johns Hopkins; University, school of Hygiene and Public Health, Baltimore, MD; 21205.
This article is an interview with Dr. Celestino Alvarez Lajonchere, Director of the National Institute of Sex Education in Havana, Cuba . The topics of discussion include reproductive rights issues, contraception, and abortion law; sex education in Cuba, homosexuality, and national po
Albini A; Mitchell CD; Thompson EW; Seeman R; Martin GR; Wittek AE; Quinnan GV; Laboratory for Developmental Biology and Anomalies, National; Institute of Dental Research, Bethesda, MD 20892.
Kaposi s sarcoma (KS) is a relatively low grade neoplasm, classically occurring in the skin of elderly men. A more virulent and invasive form of Kaposi s sarcoma has been described in patients with acquired immune deficiency syndrome (AIDS). The origin and identification of the tumor cells in these lesions is controve
Rompalo AM; Roberts P; Johnson K; Stamm WE; Department of Medicine, Harborview Medical Center, University of; Washington School of Medicine, Seattle 98014.
An effective empirical treatment regimen would provide a more rapid and less expensive approach to the management of homosexual men with acute proctitis. We conducted a randomized trial in 129 homosexual men who presented with acute proctitis, comparing treatment with an empirical regimen (4.8 million U of aqueous pen
Med J Aust. 1988 Jun 20;148(12):609, 612, 614-5. Unique Identifier : AIDSLINE MED/88246275
Plant AJ; Christopher PJ; Richards GA; Thomas M; Fox DG; Institute of Public Health Biosciences, Macquarie Hospital, North; Ryde, NSW.
In the United States there has been an increase in mycobacterial infections that is attributable to the acquired immunodeficiency syndrome (AIDS). Since 1983, when the first case of AIDS was reported in Australia , there have been 523 patients (to
Burton ZF; Killeen M; Sopta M; Ortolan LG; Greenblatt J; Banting and Best Department of Medical Research, University of; Toronto, Ontario, Canada.
We have previously shown by affinity chromatography that RAP30 and RAP74 are the mammalian proteins that have the highest affinity for RNA polymerase II. Here we show that RAP30 binds to RAP74 and that the RAP30-RAP74 complex (RAP30/74) is required for accurate initiation by RNA polymerase II. RAP30/74 is required for
Schlapfer TE; Fisch HU; Psychiatrische Poliklinik der Universitat, Bern.
Cerebral infection with human immunodeficiency virus can result in the development of symptoms covering a wide spectrum of psychiatric disorders and including adjustment disorders, affective disorders, delirium and dementia . The rapid and insidious nature of the disease requires an
Am J Forensic Med Pathol. 1988 Jun;9(2):141-8. Unique Identifier : AIDSLINE MED/88250195
Klatt EC; Noguchi TT; Department of Pathology, Los Angeles County-University of; Southern California Medical Center 90033.
The current worldwide epidemic of AIDS will have profound consequences not only for the delivery of health care, but also for forensic pathologists and investigators. AIDS continues to spread in definable risk groups, and deaths within some of these groups may fall under the jurisdiction of the medical examiner. We ou
Ann Emerg Med. 1988 Jul;17(7):700-3. Unique Identifier : AIDSLINE MED/88250663
Baker JL; Department of Emergency Medicine, Johns Hopkins University School; of Medicine, Baltimore, Maryland.
The risk to health care providers of acquiring human immunodeficiency virus (HIV) infection through occupational exposure is very low, but the consequences of becoming infected are obviously severe. The magnitude of this risk has been debated extensively in the medical literature, but the majority of these discussions
Gaut P; Wong PK; Meyer RD; Department of Medicine, Cedars-Sinai Medical Center, UCLA School; of Medicine, 90048.
Pyomyositis is an acute bacterial infection of skeletal muscle. It is a common disease in the tropics; fewer than 50 cases of pyomyositis have been reported in the continental United States . Most patients are healthy males, although the disease has been reported in diabetics and in the
Israelski DM; Skowron G; Leventhal JP; Long I; Blankenship CF; Barrio GW; Prince JB; Araujo FG; Remington JS; Department of Immunology and Infectious Diseases, Research; Institute, Palo Alto Medical Foundation, CA 94301.
Toxoplasma gondii was identified in a stained slide preparation of, and isolated from, peritoneal fluid specimens obtained from a patient with the acquired immunodeficiency syndrome (AIDS). At the time of admission to the hospital, the patient s serologic tests were positive for Toxoplasma. Toxoplasma was isolated fro
Smith FB; Rajdeo H; Panesar N; Bhuta K; Stahl R; Department of Pathology, Westchester County Medical Center,; Valhalla, NY.
Fifteen partial parotid salivary gland resection specimens interpreted as benign lymphoepithelial lesion (BLL) were accessioned by our surgical pathology service between January 1983 and December 1986. Twelve of the specimens were removed from 11 prison inmates referred to our hospital, a patient subgroup constituting
Biochem Biophys Res Commun. 1988 Jun 16;153(2):888-96. Unique Identifier : AIDSLINE MED/88251432
Folkers K; Langsjoen P; Nara Y; Muratsu K; Komorowski J; Richardson PC; Smith TH; Institute for Biomedical Research, University of Texas, Austin; 78712.
AIDS patients (2 groups) had a blood deficiency (p less than 0.001) of coenzyme Q10 vs. 2 control groups. AIDS patients had a greater deficiency (p less than 0.01) than ARC patients. ARC patients had a deficiency (p less than 0.05) vs. control. HIV-infected patients had a deficiency (p less than 0.05) vs. control. The
Papadopoulos NM; Costello R; Ceroni M; Moutsopoulos HM; Clinical Chemistry Service, Clinical Center, NINCDS, Bethesda, MD; 20892.
Zone electrophoresis on agarose gel was performed on serum samples from HIV-antibody carriers and negative controls. Nitrocellulose strips precoated with an HIV preparation were then placed on top of the gels and developed by an immunoblotting procedure. A positive reaction was demonstrated between the HIV antigens an
Murray RJ; Becker P; Furth P; Criner GJ; Department of Medicine, University of Maryland School of; Medicine, Baltimore 21201.
We describe a patient who presented with cryptococcosis and the adult respiratory distress syndrome (ARDS) as the initial manifestation of the acquired immunodeficiency syndrome. This patient represents the first reported recovery from ARDS secondary to widespread cryptococcosis. He is currently doing well as an outpa
Muller F; Muller KH; Department of Medical Microbiology, Institute of Hygiene,; Hamburg.
Serum samples from 247 patients with positive HIV-1 IgG serology were investigated for specific IgM antibodies. We found that 109 also reacted positively with a least one antigen in an HIV-1 IgM Western Blot and only 31 in an HIV-1 IgM enzyme-linked immunosorbent assay (ELISA). It was shown that in some of the persons
Shepp DH; Chakrabarti S; Moss B; Quinnan GV Jr; Division of Virology, Center for Drugs and Biologics, Food and; Drug Administration, Bethesda, Maryland.
Muller F; Moskophidis M; Schmitz H; Hygienisches Institut, Hamburg, Federal Republic of Germany.
Intrathecal synthesis of immunoglobulin G (IgG) specific to Treponema pallidum, ssp. pallidum, or to the human immunodeficiency virus 1 (HIV-1) was investigated in patients with contemporary treponemal and HIV-1 infections. Using a T. pallidum and an HIV-1 IgG enzyme-linked immunosorbent assay, specific antibody units
Pyle SW; Dubois GC; Robey WG; Bess JW Jr; Fischinger PJ; Arthur LO; Program Resources, Inc., Frederick, Maryland 21701.
External envelope glycoprotein from cell membranes and culture media of H9 cells infected with human immunodeficiency virus type 1 (HIV-1) isolate HTLV-IIIRF was isolated by immunoaffinity chromatography and compared with similar materials isolated from another variant, HTLV-IIIB. Envelope glycoprotein from IIIB and I
N Engl J Med. 1988 Jun 23;318(25):1645-50. Unique Identifier : AIDSLINE MED/88232828
Kelen GD; Fritz S; Qaqish B; Brookmeyer R; Baker JL; Kline RL; Cuddy RM; Goessel TK; Floccare D; Williams KA; et al; Division of Emergency Medicine, Johns Hopkins University School; of Medicine, Baltimore, MD.
To determine the extent of unrecognized human immunodeficiency virus (HIV) infection, we examined blood samples drawn from patients presenting to an inner-city emergency department. We found 119 of 2302 consecutive adult patients (5.2 percent) to be seropositive for HIV. Although 27 patients presented with known sympt
Fiala M; Cone LA; Cohen N; Patel D; Williams K; Casareale D; Shapshak P; Tourtelotte W; Department of Medicine, Eisenhower Medical Center, Rancho Mirage,; California 92270.
Fourteen patients with AIDS were treated for 23 neurologic complications: four episodes of acute meningoencephalitis; eight episodes of subacute encephalopathy; two cases of progressive multifocal leukoencephalopathy; and nine cases of polyneuropathy. Nine patients were treated with 9-(1,3-dihydroxy-2-propoxymethyl)gu
Science. 1988 Jun 3;240(4857):1333-5. Unique Identifier : AIDSLINE MED/88235915
Lui KJ; Darrow WW; Rutherford GW 3d; Division of Injury Epidemiology and Control, Centers for Disease; Control, Atlanta, GA 30333.
Because of the difficulty in identifying the date of exposure to type 1 of the human immunodeficiency virus (HIV-1) infection in persons other than transfusion recipients, studies of the incubation periods for acquired immunodeficiency syndrome (AIDS) have been limited. When data from a cohort of 84 homosexual and bis
Ann Neurol. 1988 Mar;23(3):308-10. Unique Identifier : AIDSLINE MED/88239506
Hormigo A; Bravo-Marques JM; Souza-Ramalho P; Pimentel J; Teixeira C; Martins R; Department of Neurology, Instituto Portugues de Oncologia,; Lisbon, Portugal.
A 35-year-old woman developed longstanding uveitis and later a uveomeningoencephalitis of unknown origin and died of toxoplasmal brain abscesses. The presence of immunological impairment, human immunodeficiency virus type 2 (HIV-2) seropositivity, and multinucleated cells in the brain led us to suspect neurotropic pro
Wescott WB; Correll RW; Dental Service, VA Medical Center, San Francisco 94121.
A patient with bilateral hairy leukoplakia and candidiasis of the tongue was diagnosed and described. Lesions of the tongue that should be considered in the differential diagnosis include: idiopathic clinical leukoplakia, tobacco-induced leukoplakia, frictional keratosis, edema, lichen planus, galvanic lesions, geogra
Fox PC; Wolff A; Yeh CK; Atkinson JC; Baum BJ; Clinical Investigations and Patient Care Branch, National; Institute of Dental Research, Bethesda, MD 20892.
Biochem Biophys Res Commun. 1988 Jun 16;153(2):825-31. Unique Identifier : AIDSLINE MED/88251423
Matthes E; Lehmann C; Scholz D; Rosenthal HA; Langen P; Central Institute of Molecular Biology, Academy of Sciences, GDR,; Berlin-Buch.
3 -fluorothymidine (FddThd) is well phosphorylated to the 5 -triphosphate in various relevant cell-lines. This results in fairly stable levels of this compound without accumulation of the 5 -monophosphate to the extent described for 3 -azidothymidine (AzT). The di- and triphosphate of FddThd seems unable to influence
Palmisano L; Chisesi T; Galli M; Gritti FM; Ielasi G; Lazzarin A; Mezzaroma I; Moroni M; Raise E; Vaglia A; et al; Industria Farmaceutica Serono, Rome, Italy.
Thirty-four patients with AIDS-related complex (ARC) were treated for 6 months with thymostimulin, a thymic hormone. Clinical and immunological findings after a 1-year follow-up were compared with those in 24 age- and sex-matched controls receiving no immunotherapy. Statistical evaluation after 6 and 12 months showed
Hubbard RL; Marsden ME; Cavanaugh E; Rachal JV; Ginzburg HM; Center for Social Research and Policy Analysis, Research Triangle; Institute, Research Triangle Park, North Carolina 27709.
Drug-abuse treatment may have important direct and indirect effects on restricting the spread of infection with human immunodeficiency virus by decreasing the prevalence of intravenous drug use and by decreasing regular drug use that impairs the immune system. Drug-abuse treatment results in substantial declines in th
Konig R; Ashwell G; Hanover JA; Laboratory of Biochemistry and Metabolism, National Institute of; Diabetes, Digestive and Kidney Diseases, Bethesda, Maryland; 20892.
The T-cell surface glycoprotein CD4 plays an important role in mediating cellular immunity and serves as the receptor for human immunodeficiency virus. We have examined the glycosylation of CD4 and asked whether carbohydrate addition is essential for proper expression of the glycoprotein on the cell membrane. Under co
Waskin H; Stehr-Green JK; Helmick CG; Sattler FR; Division of Parasitic Diseases, Centers for Disease Control,; Atlanta.
In 1984, three patients died of severe hypoglycemia after receiving pentamidine isethionate to treat Pneumocystis pneumonia. These deaths occurred on days 8, 12, and 19 of treatment, respectively. To assess risk factors associated with pentamidine treatment and hypoglycemia, we reviewed records of patients treated wit
Am J Public Health. 1988 Jul;78(7):801-5. Unique Identifier : AIDSLINE MED/88250481
Valdiserri RO; Lyter D; Leviton LC; Callahan CM; Kingsley LA; Rinaldo CR; Falk Clinic Laboratories, University of Pittsburgh, PA 15213.
Nine hundred fifty-five of 1,384 (69 per cent) gay and bisexual men enrolled in a prospective study of the natural history of human immunodeficiency virus (HIV) infection who reported engaging in anal intercourse in the past six months were surveyed about condom use practices for both insertive (IAI) and receptive ana
Can Med Assoc J. 1988 Jun 1;138(11):1005-11. Unique Identifier : AIDSLINE MED/88223050
Danielson KJ; Stewart DE; Lippert GP; Department of Psychiatry, University of Toronto, Ont.
Unproven and disproven remedies continue to abound for illnesses for which conventional treatment is only partially effective. This is particularly true with cancer, for which up to 50% of patients may be receiving unorthodox therapy. This article examines unconventional cancer remedies, their adverse effects, their c
Jeffrey RB Jr; Goodman PC; Olsen WL; Wall SD; University of California, San Francisco.
The acquired immunodeficiency syndrome (AIDS) is an increasingly important disease that has become a social phenomenon. Although our therapeutic options for treating AIDS patients are limited at present, radiologic investigation is often of crucial importance in determining the extent and stage of opportunistic infect
Robinson WE Jr; Mitchell WM; Chambers WH; Schuffman SS; Montefiori DC; Oeltmann TN; Department of Pathology, Vanderbilt University, Nashville, TN.
Cytolytic activity of human mononuclear peripheral blood leukocytes from healthy donors, cultured in interleukin-2 conditioned medium, was abrogated by in vitro infection with the lymphadenopathy associated virus (LAV) isolate of the human immunodeficiency virus (HIV). Although viral antigens are not expressed in cult
Morfeldt-Manson J; Julander I; von Stedingk LV; Wasserman J; Nilsson B; Department of Infectious Diseases, Roslagstull Hospital,; Karolinska Institute, Stockholm.
For evaluation of its prognostic value, the level of serum beta-2-microglobulin was determined in early serum samples from 88 patients with persistent generalized lymphadenopathy in a prospective longitudinal study. Patients with serum beta-2-microglobulin greater than 2.6 mg/l were found to have a significantly highe
Ostrow D; Grant I; Atkinson H; Institute for Social Research, University of Michigan, Ann Arbor; 48109.
The studies reviewed here and ongoing work indicate a primary role for psychiatry in treating patients with the acquired immunodeficiency syndrome (AIDS) and human immunodeficiency virus (HIV) infection. Those patients often have neuropsychiatric disorders concurrent with the complications of physical disease. It is i
Saxon A; Campen V; Department of Medicine, UCLA School of Medicine, Los Angeles, CA; 90024-1680.
In this article I have addressed many of the AIDS issues of concern to immunologists and allergists, both as citizens, physicians, and as specialists. HIV infection (AIDS) is going to be with us for some time to come. However, I think some solace can be gained from the fact that the human race has faced many such cont
Hopewell PC; Medical Service, San Francisco General Hospital, California; 94110.
Pneumocystis carinii pneumonia occurs at some point in the course of illness in approximately 85% of patients with AIDS. Because of the frequency of P. carinii pneumonia and because it is readily treatable, prompt, accurate, and efficient diagnostic schemes are extremely important. The clinical presentation is general
Hochberg FH; Miller DC; Department of Neurology, Massachusetts General Hospital, Boston.
Primary lymphoma of the central nervous system (CNS), including reticulum cell sarcoma, microglioma, and histiocytic lymphoma, represents less than 1% of all primary brain tumors. In the last 10 years, this tumor has tripled in frequency in the nonimmunosuppressed population. By 1991, the tumor will be the most common
Zuckier LS; Ongseng F; Goldfarb CR; Department of Radiology, Albert Einstein College of Medicine,; Bronx, New York.
Lymphocytic interstitial pneumonitis (LIP) is currently recognized as a frequent pediatric manifestation of the acquired immunodeficiency syndrome (AIDS). We report the gallium scan findings in a 3-yr-old girl with this disorder and review its clinical, radiologic, and pathologic features. LIP must be a prime consider
Med Cutan Ibero Lat Am. 1988;16(1):61-5. Unique Identifier : AIDSLINE MED/88231927
Diaz-Perez JL; Gardeazabal J; Zubizarreta J; Goday J; Servicio de Dermatologia, Hospital de Cruces, Baracaldo, Bilbao.
A patient with a acquired immunodeficiency syndrome (AIDS) and Kaposi s angiosarcoma developed bowenoid papulosis of the genitalia (BP). The clinical and histopathological criteria were both characteristic of BP. With vinblastine treatment a moderate improvement of Kaposi s lesions was observed, but no significant cha
Nature. 1988 Jun 9;333(6173):519-22. Unique Identifier : AIDSLINE MED/88232931
Levy JA; Department of Medicine, University of California School of; Medicine, San Francisco 94143-0128.
A number of problems still surround infection by the human immunodeficiency virus and the pathogenesis of AIDS. Solutions to the problems would provide valuable information for the development of antiviral therapy and a vaccine.
Weissman I; Department of Pathology, Stanford University School of Medicine,; California 94305.
AIDS, presumably caused by the human retrovirus, human immunodeficiency virus (HIV), is a disease with multiple pathologies, most of which are the consequence of a profound immunodeficiency. The first two sections of this review focus primarily on the normal development and function of the cells of the immune system a
Henry K; Sullivan C; Crossley K; Department of Internal Medicine, St. Paul-Ramsey Medical Center,; Minnesota 55101.
Nasal septal abscess is a potentially serious infection about which there has been little information in the infectious disease literature. A patient with acquired immunodeficiency syndrome who developed a nasal septal abscess was studied, and the literature about this infection was reviewed.
Science. 1988 Jun 10;240(4858):1427-35. Unique Identifier : AIDSLINE MED/88235933
Varmus H; Department of Microbiology and Immunology, School of Medicine,; University of California, San Francisco 94143.
First brought to scientific attention as infectious cancer-causing agents nearly 80 years ago, retroviruses are popular in contemporary biology for many reasons. (i) The virus life cycle includes several events--in particular, reverse transcription of the viral RNA genome into DNA, orderly integration of viral DNA int
Lelie PN; Reesink HW; Huisman H; Central Laboratory Netherlands Red Cross Blood Transfusion; Service.
The second-generation enzyme immunoassays (EIAs) for antibodies against human immunodeficiency virus (HIV) from three manufacturers (Abbott, Organon, Wellcome) and three anti-HIV confirmatory tests, i.e. Western Blot (WB, Biotech, Dupont), radioimmunoprecipitation assay (RIPA, CLB) and a competitive immunoassay (CIA,
Autio-Harmainen H; Karttunen T; Apaja-Sarkkinen M; Dammert K; Risteli L; Department of Pathology, University of Oulu, Finland.
Immunohistochemical staining was used to demonstrate basement membrane (BM) laminin and type IV collagen in eight cases of Kaposi s sarcoma (KS). These KS were not associated with AIDS and represented different histological stages of the disease: patch (three cases), plaque (one case), and nodule (four cases). Nine ca
Brettler DB; Forsberg AD; Levine PH; Andrews CA; Baker S; Sullivan JL; New England Area Comprehensive Hemophilia Center, Worcester, MA; 01605.
Virus isolation studies and human immunodeficiency virus (HIV) antibody testing were performed on 87 household contacts of 68 HIV antibody-positive hemophilic patients to determine the extent that HIV could be transmitted through heterosexual or through nonsexual, but intimate contact. Human immunodeficiency virus ser
Gray F; Gherardi R; Scaravilli F; Department de Pathologie (Neuropathologie), Hopital Henri; Mondor, Creteil, France.
The nervous system has been involved in the majority (at least 75%), of cases of acquired immune deficiency syndrome (AIDS) examined postmortem, but the pathogenetic mechanisms involved are not well understood. The predominant pathological process is opportunistic infection secondary to the decrease of T-helper (T4) c
Feinkind L; Minkoff HL; Department of Obstetrics and Gynecology, State University of New; York, Brooklyn.
Human immunodeficiency virus is becoming increasingly common among childbearing women. Through federally recommended testing programs, obstetricians will soon be identifying pregnant women in their practices who are HIV infected. Hence obstetricians must be prepared to face the social, ethical, and medical dilemmas br
Ibanez OM; Mouton D; Oliveira SL; Ribeiro Filho OG; Piatti RM; Sant'Anna OA; Massa S; Biozzi G; Siqueira M; Secao de Immunologia, Instituto Biologico, Sao Paulo, Brazil.
Among the differences observed between the various high (H) and low (L) antibody responder lines of mice resulting from distinct bidirectional selective breedings, one of the most puzzling is the variation in the multispecific effect, i.e., in the modification of antibody responses to antigens unrelated to those used
Adams SE; Johnson ID; Braddock M; Kingsman AJ; Kingsman SM; Edwards RM; Department of Molecular Biology, British Bio-technology Ltd,; Cowley, Oxford, UK.
The synthesis of a gene for the HIV TAT protein is described using a novel approach that capitalises on the ability to synthesise oligonucleotides of greater than 100 bp in length. It involves the synthesis of large oligomers covering one strand of the desired gene in its entirety and the use of small complementary br
Sze G; Zimmerman RD; Department of Radiology, New York Hospital-Cornell Medical; Center, New York.
The MR features of inflammatory lesions of the central nervous system are reviewed in this article, and the sensitivity and specificity of MR and CT in the detection of these lesions are compared. The advent of CT dramatically improved the morbidity and mortality of inflammatory disease by facilitating earlier and mor
Ohno T; Kanoh T; Suzuki T; Masuda T; Kuribayashi K; Araya S; Arai H; Uchino H; Department of Internal Medicine, Faculty of Medicine, Kyoto; University.
A variety of phenotypic abnormalities of peripheral blood lymphocytes from 8 HIV-carriers (HIVC), 6 patients with common variable immunodeficiency disease (CVID), and 13 patients with selective immunoglobulin deficiency (SIgD) were compared using two-color flow cytometry. There was a close resemblance in phenotypic ab
Tzipori S; Department of Microbiology, Royal Children's Hospital, Melbourne,; Australia.
In this review I have examined the vast literature which has accumulated on Cryptosporidium, particularly in the past 3 years, in an attempt to highlight areas in which progress has been made in relation to the organism and the disease, and to indicate areas in which knowledge is still lacking. Since 1982, a global ef
A patient with hemophilia A and transfusion-associated end-stage chronic liver disease underwent orthotopic liver transplantation. He had no requirement for exogenous factor VIII replacement during the 27 mo he survived. Although his hemophilia was cured, he had antibodies to the human immunodeficiency virus; ultimate
Siegman-Igra Y; Maayan S; Pitlik SD; Costin C; Swartz T; Michaeli D; Infectious Diseases Unit, Ichilov Hospital, Tel Aviv Medical; Center, Israel.
Between mid-1982 and 1 January 1988, 35 cases of AIDS among permanent residents of Israel were reported to the Israel Ministry of Health. In contrast to the experience in the United States and Europe, the semiannual incidence rates of AIDS are low a
JAMA. 1988 Jun 24;259(24):3563-6. Unique Identifier : AIDSLINE MED/88230810
Wykoff RF; Heath CW Jr; Hollis SL; Leonard ST; Quiller CB; Jones JL; Artzrouni M; Parker RL; Department of Health and Environmental Control, Greenwood.
This report describes a contact investigation conducted in rural South Carolina to identify, counsel, and educate persons infected with or exposed to the human immunodeficiency virus (HIV). Starting with one HIV antibody-positive man and his 19 sex contacts, we identified 83 sex contacts of HIV antibody-positive men.
Nature. 1988 Jun 9;333(6173):573-5. Unique Identifier : AIDSLINE MED/88232939
Smith TF; Srinivasan A; Schochetman G; Marcus M; Myers G; MBCRR Dana-Farber Cancer Institute, Harvard University, Boston,; Massachusetts 02115.
Knowledge of the phylogenetic history of the human immunodeficiency viruses (HIV-1 and HIV-2) is important for our understanding of the epidemiology of AIDS, the disease caused by these viruses. Reconstruction of the evolutionary tree is hampered, however, by two problems. One is the high variation in nucleotide seque
Fischer GW; Department of Pediatrics, Uniformed Services University of the; Health Sciences, F. Edward Hebert School of Medicine, Bethesda,; Maryland.
Immunoglobulin plays a critical role in the immune response to many pediatric illnesses. We have just begun to explore the potential uses of IVIG in the prevention and treatment of pediatric diseases. The ability to give large amounts of antibody quickly and with repeated doses will allow physicians to achieve and mai
Excler JL; Standaert B; Ngendandumwe E; Piot P; Centre Hospitalier Universitaire de Kamenge, Bujumbura, Burundi.
HIV infection was present in 18 out of 40 (45%) consecutive malnourished children aged 2 to 29 months in pediatric wards of Bujumbura, Burundi . No difference was observed within and between the seropositive and seronegative groups for sex and anthropometric measures. HIV seroposit
Proc Natl Acad Sci U S A. 1988 Jun;85(11):3995-9. Unique Identifier : AIDSLINE MED/88234545
Borrebaeck CA; Danielsson L; Moller SA; Department of Biotechnology, University of Lund, Sweden.
A general procedure is described for the production of human monoclonal antibodies from peripheral blood lymphocytes immunized in vitro against T-cell-dependent antigens. These lymphocytes immunized in culture were used to produce human-human or human-mouse hybridomas secreting monoclonal antibodies specific for digox
Public Health Rep. 1988 May-Jun;103(3):213-20. Unique Identifier : AIDSLINE MED/88234860
Dondero TJ Jr; Pappaioanou M; Curran JW; AIDS Program, Centers for Disease Control (CDC), Atlanta, GA; 30333.
A comprehensive, multifaceted approach to HIV surveillance is needed to provide the information necessary for public health management and policy. Because HIV infection is not readily or uniformly ascertained, survey methods and sentinel surveillance approaches must be used. At least some of the surveys must be blinde
Public Health Rep. 1988 May-Jun;103(3):221-3. Unique Identifier : AIDSLINE MED/88234861
Samuels ME; Mann J; Koop CE; Public Health Service, Rockville, MD 20857.
The World Health Organization (WHO) estimates that the world total of AIDS cases will reach 300,000 by the end of 1988 and 500,000 to 3 million over the next 5 years. AIDS is of special concern to developing countries with their limited, stressed health care systems and the other serio
Public Health Rep. 1988 May-Jun;103(3):224-9. Unique Identifier : AIDSLINE MED/88234862
Broder S; Fauci AS; Clinical Oncology Program, National Cancer Institute, Bethesda,; MD 20892.
The discovery of effective therapies for HIV requires a fundamental knowledge of retroviral infections. Research by the Public Health Service and collaborating organizations on oncogenic viruses, including retroviruses, has provided much of the basic understanding of retroviruses in general and anti-retroviral therape
Public Health Rep. 1988 May-Jun;103(3):230-6. Unique Identifier : AIDSLINE MED/88234863
Fauci AS; Fischinger PJ; National Institute of Allergy and Infectious Diseases, Bethesda,; MD 20892.
The development of a safe and effective vaccine against infection by the human immunodeficiency virus (HIV) is of paramount importance to the prevention of AIDS worldwide. Although a great deal has been learned about HIV in a few short years, the development of an AIDS vaccine has proved to be extremely difficult. The
Public Health Rep. 1988 May-Jun;103(3):236-41. Unique Identifier : AIDSLINE MED/88234864
Petricciani JC; Epstein JS; FDA Center for Drugs and Biologics, Bethesda, MD 20892.
Present safeguards for the blood supply consist of three tiers of protection: donor deferral based on a donor s history of risk factors, confidential exclusion of blood units from donors with self-admitted risk factors, and testing of the blood itself. Before the discovery of the AIDS virus in 1983 and 1984, there was
Public Health Rep. 1988 May-Jun;103(3):242-5. Unique Identifier : AIDSLINE MED/88234865
Young FE; Office of Public Affairs, Rockville, MD 20857.
The Food and Drug Administration has instituted several pro-active measures to expedite the review of treatments, diagnostics, and vaccines for AIDS and related conditions. In particular, the agency has established a special designation--1-AA--for a potential AIDS product which gives top priority to its review. This s
Public Health Rep. 1988 May-Jun;103(3):261-6. Unique Identifier : AIDSLINE MED/88234868
Schuster CR; National Institute on Drug Abuse, Rockville, MD 20857.
Research programs of the National Institute on Drug Abuse take a broad approach to investigating the problems of intervention in intravenous drug use and its relation to the AIDS epidemic. Current prevention strategies are directed to reducing the rates of infection and the progression among the infected to clinical s
Public Health Rep. 1988 May-Jun;103(3):267-72. Unique Identifier : AIDSLINE MED/88234869
Richland JH; Personal Health Research, Public Health Foundation, Washington,; DC 20005.
State health agencies have assumed a leadership role in responding to the major public health issues raised by the AIDS epidemic. Directors of State health agencies (State health officers) have asserted their influence at the national level as well as at the State level. The Association of State and Territorial Health
Public Health Rep. 1988 May-Jun;103(3):273-7. Unique Identifier : AIDSLINE MED/88234870
McCarthy C; American Hospital Association, Chicago, IL 60611.
The American Hospital Association (AHA) has taken a leadership role in assisting health care providers in dealing effectively with the challenges of AIDS. Early work focused on preventing infection in the health care setting with the use of the Centers for Disease Control s recommended precautions concerning blood and
Public Health Rep. 1988 May-Jun;103(3):278-81. Unique Identifier : AIDSLINE MED/88234871
Spero JR; University of Cincinnati School of Nursing.
Nursing students, as future health care providers, need comprehensive instruction about AIDS--the many manifestations of both the disease itself and the pandemic. As health educators and practitioners, nurses play a major role in safeguarding the health care setting and the community by their efforts in preventing tra
Public Health Rep. 1988 May-Jun;103(3):282-8. Unique Identifier : AIDSLINE MED/88234872
Hotchkiss WS; American Medical Association, Chicago, IL 60610.
Since the identification of acquired immunodeficiency syndrome (AIDS) in 1981 as a distinct disease entity, the number of AIDS cases has steadily increased in the United States and throughout the world. Although the primary etiologic agent of AIDS, human immunodeficiency virus (HIV), h
Public Health Rep. 1988 May-Jun;103(3):289-92. Unique Identifier : AIDSLINE MED/88234873
Weiss R; Thier SO; Institute of Medicine, Washington, DC 20418.
In 1985 the Institute of Medicine, National Academy of Sciences devoted its annual meeting to an exploration of acquired immunodeficiency syndrome (AIDS). The questions raised at the meeting propelled the IOM/NAS to initiate an assessment of the dimensions of the AIDS epidemic and to propose an appropriate national re
Public Health Rep. 1988 May-Jun;103(3):293-8. Unique Identifier : AIDSLINE MED/88234874
Sundwall DN; Bailey D; Health Resources and Services Administration, Rockville, MD; 20857.
The Health Resources and Services Administration (HRSA), one of the seven agencies of the Public Health Service, is working to meet some of the resource and patient service needs engendered by the epidemic of acquired immune deficiency syndrome (AIDS). Those actions derived from, and support the continuation, expansio
Public Health Rep. 1988 May-Jun;103(3):299-304. Unique Identifier : AIDSLINE MED/88234875
Kawata PA; Andriote JM; National AIDS Network, Washington, DC 20005.
Because of the variety of needs engendered by AIDS, a broadbased response to the epidemic is warranted. The traditional medical model, with its emphasis on inpatient hospital care, is expensive and fails to address other needs of people with AIDS (PWAs). This paper outlines an alternative model: the community-based re
Public Health Rep. 1988 May-Jun;103(3):305-8. Unique Identifier : AIDSLINE MED/88234876
Roper WL; Winkenwerder W; Health Care Financing Administration, Washington, DC 20201.
An estimated 40 percent of the nation s 55,000 persons with acquired immunodeficiency syndrome (AIDS) have received care under the Medicaid Program, which is administered by the Health Care Financing Administration (HCFA) and funded jointly by the Federal Government and the States. In fiscal year 1988, Medicaid will s
Abramson JS; Mills EL; Department of Pediatrics, Bowman Gray School of Medicine,; Winston-Salem, North Carolina 27103.
A large body of evidence has accumulated indicating that viruses can predispose animal and human hosts to secondary local and systemic bacterial and fungal disease. The mechanism by which viruses cause these superinfections involves both a direct effect of viruses on the tissues at the site of infection and alteration
Rudy T; Opelz G; Gerlach R; Daniel V; Schimpf K; Department of Transplantation Immunology, University of; Heidelberg, FRG.
65 patients belonging to known acquired-immune-deficiency-syndrome (AIDS) risk groups were tested for mitogen responsiveness to pokeweed mitogen, concanavalin A and phytohemagglutinin, percentages of peripheral blood CD4, CD8 and Leu7 lymphocyte subsets, serum neopterin levels, and gamma-interferon (gamma-IFN) concent
De Wit S; Taelman H; Van de Perre P; Rouvroy D; Clumeck N; Division of Infectious Diseases, St. Pierre University Hospital,; Brussels, Belgium.
During a two-year period, 26 Central African patients with AIDS or AIDS-related complex were seen in two Belgian hospitals and five of these patients presented with non-typhoid Salmonella bacteremia. Three additional patients were observed in a Rwandese hospital. These eight African patients were compared with 16 non-
Wright SC; Jewett A; Mitsuyasu R; Bonavida B; Department of Microbiology and Immunology, UCLA School of; Medicine, Los Angeles, CA 90024.
Peripheral blood monocytes (PBM) from AIDS patients have exhibited defects in some but not all of the immune functions yet tested. This study has examined the capacity of AIDS PBM to lyse tumor target cells as well as their ability to secrete TNF. Untreated PBM from AIDS patients were significantly cytotoxic to U937 t
Kane RE; Jennison K; Wood C; Black PG; Herbst JJ; Department of Pediatrics, University of Utah Medical Center, Salt; Lake City 84132.
Our Cystic Fibrosis (CF) Center made an effort to utilize home intravenous antibiotic therapy (HIVAT) as an alternative to continued hospitalization during a 1-year study. After thorough individual clinical and financial evaluation, 27 of 41 CF patients admitted for treatment, including antibiotic therapy, were select
Murray HW; Scavuzzo DA; Kelly CD; Rubin BY; Roberts RB; Division of Infectious Diseases, Cornell University Medical; College, New York.
To fully characterize the relationship between the clinical manifestations of human immunodeficiency virus infection and T4+ cell defects, we determined T4+ cell number and interferon gamma (IFN-gamma) production in 238 patients. For asymptomatic homosexuals, patients with acquired immunodeficiency syndrome (AIDS)-rel
Prince HE; Kleinman SH; Maino VC; Jackson AL; Cellular Immunology Laboratory, American Red Cross Blood; Services, Los Angeles, California 90006.
We investigated the relationship of soluble interleukin 2 receptor (sIL2R) production to cellular IL2R expression and DNA synthesis by mitogen-stimulated mononuclear cells from blood donors seropositive for human immunodeficiency virus (HIV). SIL2R was measured using an enzyme-linked immunosorbent assay which employed
Zunich KM; Kirkpatrick CH; Conrad D. Stephenson Laboratory for Research in Immunology,; National Jewish Center for Immunology and Respiratory Medicine,; Denver, Colorado 80206.
Enkephalins have been shown to enhance T cell-mediated immune responses and natural killer-cell activity in vitro. We have studied the effects of infusions of methionine-enkephalin on immune functions and clinical courses in seven patients with various stages of infection with human immunodeficiency virus (HIV). All p
Daijardin JB; Artaxe H; Agis F; Ducosson P; Cottelon P; Riff H; Armougon J; Gabriel JM; Salin J; Dramort G; et al; Service de Reanimation polyvalente, CHR de Pointe a Pitre; (Abymes).
By December 31, 1986, 38 cases of AIDS had been notified in Guadeloupe (French West Indies). Transmission of the disease was predominantly heterosexual; 79 p. 100 of the patients were devoid of risk factor. Sex ratio was 2.2, but th
Meignan M; Rosso J; Picard C; Mayaud C; Revuz J; Akoun G; Galle P; Service de Medecine nucleaire, Hopital Henri Mondor, Creteil.
In eleven patients with AIDS and suspected Pneumocystis carinii pneumonia we measured the pulmonary clearance and half-life of aerosolized 99m Tc-DTPA (diethylenetriamine pentaacetate). We correlated the half-life with gallium scans and bronchoalveolar lavages. In all nine patients with Pneumocystis, this half-life wa
We measured the number of Langerhans cells in clinically normal epidermis and the number of T4 lymphocytes in the plasma in 24 patients infected with HIV, and related these to the stage of the disease. A correlation is demonstrated between the numbers of Langerhans cells and T4 lymphocytes. Numbers of Langerhans cells
Postol LP; Seyfarth, Shaw, Fairweather & Geraldson, Washington, DC 20036.
In dealing with applicants and employees, administrators must comply with handicap and pregnancy discrimination statutes, any union collective bargaining agreement, and any state or local statutes specifically directed at protecting certain classes of handicapped persons. The employer must make reasonable accommodatio
Krasinski K; Borkowsky W; Bonk S; Lawrence R; Chandwani S; Department of Pediatrics, New York University Medical Center, NY; 10016.
A retrospective review of 71 children infected with human immunodeficiency virus cared for over a 3.5-year period revealed that 44 of 71 (63%) required a bacterial culture and 27 of 71 (37%) had bacteriologically documented infection. There were 125 episodes in 27 patients. Pneumonia (24 of 125 (19%)), upper respirato
The main species of mycobacteria isolated in 62 of the 316 acquired immunodeficiency syndrome patients admitted to the Claude Bernard Hospital, Paris, between January, 1983 and October, 1986 were studied retrospectively according to their site of isolation and their pathogenic role. Mycobacterium tuberculosis was isol
Presse Med. 1988 May 21;17(19):953-6. Unique Identifier : AIDSLINE MED/88247946
Serratrice G; Centre hospitalier universitaire de la Timone, Marseille.
The causes of polymyositis are imperfectly known. The role of Toxoplasma, the myotropism of which is significant in acute myositis, may be suspected on the ground of secondary serological data, but it has not yet been confirmed. On the other hand, the role of coxsackie virus, which until recently had been established
Proc Natl Acad Sci U S A. 1988 Jun;85(12):4200-4. Unique Identifier : AIDSLINE MED/88247989
Rice AP; Mathews MB; Cold Spring Harbor Laboratory, NY 11724.
The human immunodeficiency virus 1 (HIV-1) long terminal repeat (LTR) sequences were inserted into adenovirus in place of the E1 region. The HIV-1 LTR contained in this recombinant adenovirus responds to trans-activation by tatIII in a HeLa cell line constitutively expressing that HIV-1 gene product. In addition, the
Collier AC; Corey L; Murphy VL; Handsfield HH; University of Washington, Seattle.
STUDY OBJECTIVE: To analyze the relation between human immunodeficiency virus (HIV) infection and the antibody response to plasma-derived hepatitis B vaccine. DESIGN: Open-label longitudinal cohort study; blinded laboratory studies. SETTING: University-affiliated municipal hospital. Patients: Homosexually active men w
Spigelman Z; Duff R; Beardsley GP; Broder S; Cooney D; Landau NR; Mitsuya H; Ullman B; McCaffrey R; Evans Department of Clinical Research, Boston University Medical; Center, MA 02118.
The 2 ,3 -dideoxynucleosides (ddNs) are currently undergoing clinical evaluation as antiretroviral agents in HIV-infected individuals. When phosphorylated, the ddNs (ddNTPs) function as chain-terminating substrate analogues with reverse transcriptase, thereby inhibiting HIV replication. These nucleoside analogues can
Cell. 1988 Jun 3;53(5):827-36. Unique Identifier : AIDSLINE MED/88223375
Bohnlein E; Lowenthal JW; Siekevitz M; Ballard DW; Franza BR; Greene WC; Howard Hughes Medical Institute, Department of Medicine, Duke; University Medical Center, Durham, North Carolina 27710.
Both the interleukin-2 receptor-alpha (Tac, p55, IL-2R alpha) gene and the long terminal repeat (LTR) of type 1 HIV are activated by various T cell mitogens. We now demonstrate that an inducible 86 kd nuclear protein termed HIVEN86A specifically binds to both the enhancer element of the HIV-1 LTR and a closely related
Rene E; Marche C; Chevalier T; Rouzioux C; Regnier B; Saimot AG; Negesse Y; Matheron S; Leport C; Wolff B; et al; Department of Gastroenterology, Hopital Bichat, Paris, France.
Twenty-four AIDS patients, who underwent gastrointestinal evaluation, died from their disease and were autopsied. Seven had Cytomegalovirus colitis (group I) and 17 did not (group II). Clinical manifestations, digestive lesions, and infections were compared in the two groups. Chronic watery diarrhea was present in all
FASEB J. 1988 Jun;2(9):2462-73. Unique Identifier : AIDSLINE MED/88225864
Miyajima A; Miyatake S; Schreurs J; De Vries J; Arai N; Yokota T; Arai K; Department of Molecular Biology, DNAX Research Institute of; Molecular and Cellular Biology, Palo Alto, California 94304.
In response to antigenic stimulation, helper T cells secrete a set of protein mediators called lymphokines that regulate proliferation, differentiation, and maturation of lymphocytes and hemopoietic cells. Because all known lymphokines are composed of a single polypeptide chain, their coding sequences can be isolated
Grody WW; Lewin KJ; Naeim F; Department of Pathology, UCLA School of Medicine 90024-1732.
Several lines of evidence have suggested an etiologic association of cytomegalovirus ( CMV ) with Kaposi s sarcoma. This contention is supported by a pathoepidemiologic survey of 54 cases of acquired immunodeficiency syndrome (
Witzleben CL; Marshall GS; Wenner W; Piccoli DA; Barbour SD; Department of Pathology, University of Pennsylvania Medical; School, Children's Hospital of Philadelphia 19104.
The 9-month-old daughter of human immunodeficiency virus (HIV)-seropositive parents presented with cholestasis and was found on liver biopsy to have giant cell hepatitis. No viral inclusions or particles were seen by light or electron microscopy. Ultrastructural studies of the liver biopsy demonstrated tubuloreticular
Urinary excretion of Cytomegalovirus and the presence of serum antibodies against CMV were examined in 79 HIV-1-infected patients at different stages of the disease, as well as in 27 heterosexual and 52 male homosexual controls and correlated to clinical and lab
Ball JM; Rao VS; Robey WG; Issel CJ; Montelaro RC; Department of Biochemistry, Louisiana State University, Baton; Rouge 70803.
We describe here a one step HPLC technique for purifying the four gag proteins (p26, p15, p11 and p9) and two env glycoproteins (gp90 and gp45) from purified equine infectious anemia virus (EIAV), a member of the lentivirus subfamily of retroviruses. The purification procedure employs a reverse-phase phenyl Radial-pak
Burg G; von der Helm D; Kaudewitz P; Klepzig K; Braun-Falco O; Department of Dermatology, Ludwig-Maximilians University, Munich,; Federal Republic of Germany.
In 3 patients suffering from follicular center-cell-derived B-cell lymphoma with primary cutaneous manifestation, antiadult T-cell leukemia-associated antigen antibodies were detected by the ELISA. In one of the patients, the husband and the dog had died from thymoma and from malignant lymphoma, respectively.
Kitchen LW; Cotter SM; Department of Cancer Biology, Harvard School of Public Health,; Boston, MA 02115.
Diethylcarbamazine (N,N-diethyl-4-methyl-1-piperazine carboxamide; DEC) is a drug frequently used for prevention and treatment of the filariases. An opsonic action of DEC may generate increased immune responses to microfilariae. We tested the hypothesis that DEC treatment could result in higher antibody levels to othe
Cullen BR; Hauber J; Campbell K; Sodroski JG; Haseltine WA; Rosen CA; Department of Molecular Genetics, Hoffman-La Roche, Inc., Nutley,; New Jersey 07110.
The genome of the human immunodeficiency virus is distinguished from other animal retroviruses by the presence of several additional open reading frames. The protein product of one of these novel genes, which has been termed art or trs, is required for the expression of the virus structural genes but not for the expre
Nature. 1988 Jun 2;333(6172):455-7. Unique Identifier : AIDSLINE MED/88232905
Kikuta H; Taguchi Y; Tomizawa K; Kojima K; Kawamura N; Ishizaka A; Sakiyama Y; Matsumoto S; Imai S; Kinoshita T; et al; Department of Pediatrics, Hokkaido University School of Medicine,; Sapporo, Japan.
Epstein-Barr virus (EBV), a ubiquitous human herpesvirus and an aetiological agent of infectious mononucleosis, has a unique tropism for B lymphocytes. Clinical and laboratory features of chronic active EBV infections are chronic or persistent infectious mononucleosis-like symptoms and high antibody titre against earl
Stein CA; Subasinghe C; Shinozuka K; Cohen JS; Clinical Pharmacology Branch, National Cancer Institute,; Bethesda, MD 20892.
We have recently shown that phosphorothioate (PS) oligodeoxynucleotide (ODN) analogs, unlike their normal congeners, exhibit significant anti-HIV activity (Matsukura et al., (1987) Proc. Natl. Acad. Sci. USA 84, 7706-7710). We now report the syntheses, melting temperatures (Tm), and nuclease susceptibilities of a seri
Nguyen TD; Division of Gastroenterology, Stanford University School of; Medicine, CA 94305.
Acquired immunodeficiency syndrome (AIDS) is initiated by the attachment of the human immunodeficiency virus (HIV) to specific target cells. An octapeptide sequence contained within the envelope of HIV, peptide T, mediates the viral binding. Since there is a considerable structural homology between peptide T and VIP,
Public Health Rep. 1988 May-Jun;103(3):246-54. Unique Identifier : AIDSLINE MED/88234866
Macher AM; Department of Infectious and Parasitic Disease Pathology, Armed; Forces Institute of Pathology, Washington, DC 20306-6000.
The acquired immunodeficiency syndrome (AIDS) is a devastating new disease caused by the human immunodeficiency virus (HIV). This retrovirus causes profound immunoincompetence in its infected hosts, who are thereafter susceptible to develop myriad severe and relapsing protozoal, fungal, bacterial, viral, and arthropod
Public Health Rep. 1988 May-Jun;103(3):255-60. Unique Identifier : AIDSLINE MED/88234867
Mason JO; Noble GR; Lindsey BK; Kolbe LJ; Van Ness P; Bowen GS; Drotman DP; Rosenberg ML; Centers for Disease Control (CDC), Atlanta, GA 30333.
The human immunodeficiency virus (HIV) is estimated to have infected more than a million people in the United States and millions more in other countries. Even though there is no vaccine or effective treatment, HIV infection can be prevented through behavioral change. As the lead Publi
Public Health Rep. 1988 May-Jun;103(3):309-19. Unique Identifier : AIDSLINE MED/88234877
Hellinger FJ; Division of Extramural Research, National Center for Health; Services Research and Health Care Technology Assessment (NCHSR),; Rockville, MD 20857.
The personal medical care costs of those diagnosed with acquired immunodeficiency syndrome (AIDS) in 1988 are forecast to be $2.2 billion, an amount that will increase to $4.5 billion in 1991. This is the first study to include the cost of purchasing azidothymidine (
Elder GA; Sever JL; Infectious Diseases Branch, National Institute of Neurological; and Communicative Disorders and Stroke, Bethesda, Maryland 20892.
Neurologic disease occurs frequently in patients infected with the human immunodeficiency virus (HIV), and a large body of literature now exists detailing the various infections, neoplasms, and other conditions that can affect the central nervous system (CNS) or the peripheral nervous system in children and adults wit
Temin HM; McArdle Laboratory, University of Wisconsin, Madison 53706.
Retroviruses have been studied primarily for their role in cancer. However, with the AIDS epidemic, attention has shifted to the other effects of retroviral infection. In particular, since human immunodeficiency virus results in killing of CD4-positive T cells, there is interest in the mechanism of cell killing by ret
Stoto MA; Blumenthal D; Durch JS; Feldman PH; John F. Kennedy School of Government, Harvard School of Public; Health, Harvard University, Boston, Massachusetts.
With the history of the U.S. federal budget for fiscal year 1986 as a vehicle, the usual processes in the executive branch and the Congress that establish health research priorities and the unusual developments that have shaped priorities for AIDS are described. In the 3 years between the initial formulation of the AI
Science. 1988 Jun 10;240(4858):1522-5. Unique Identifier : AIDSLINE MED/88235944
Evans LA; Moreau J; Odehouri K; Legg H; Barboza A; Cheng-Mayer C; Levy JA; Department of Medicine, University of California, San Francisco; 94143.
A new isolate of the human immunodeficiency virus type 2, designated HIV-2UC1, was recovered from an Ivory Coast patient with normal lymphocyte numbers who died with neurologic symptoms. Like some HIV-1 isolates, HIV-2UC1 grows rapidly to high titers in human peripheral blood
Ann Neurol. 1988 Mar;23(3):295-7. Unique Identifier : AIDSLINE MED/88239501
Smith T; Jakobsen J; Gaub J; Helweg-Larsen S; Trojaborg W; Department of Clinical Neurophysiology NF, Rigshospitalet,; Copenhagen, Denmark.
Motor weakness and ataxia of lower limbs and abnormalities of somatosensory evoked potentials occur in many patients with the acquired immunodeficiency syndrome (AIDS). We studied 15 human immunodeficiency virus-seropositive subjects without AIDS and found no clinical neurological abnormalities. The mean latency of th
Harrington DS; Patil K; Lai PK; Yasuda NN; Armitage JO; Ip SH; Weisenburger DD; Linder J; Purtilo DT; Department of Pathology and Microbiology, University of Nebraska; Medical Center, Omaha 68105.
We performed a retrospective analysis of serum interleukin 2 receptor (IL-2R) levels in a group of 35 patients with malignant lymphoma (ML; 13 T cell and 22 B cell) using a new enzyme immunoassay. Our objectives were to determine if elevated levels of soluble IL-2R occur in patients with active ML, whether serum IL-2R
Teich SA; Castle J; Friedman AH; Siroty W; Orellana J; Schmitterer M; Department of Ophthalmology, Beth Israel Medical Center, New; York, New York.
The eyes of an AIDS patient with cytomegalovirus ( CMV ) retinitis and pneumonitis who died while receiving maintenance therapy with the antiviral agent 9-[2-hydroxy-1-(hydroxymethyl) ethoxymethyl] guanine (Ganciclovir) were ob
The antileukemic and anti-HTLV-III (anti-HIV) agent avarol, a sesquiterpenoid hydroquinone, was determined to be converted into its corresponding quinone derivative avarone via the semiquinone free radical. Its g-value was 2.0047; after hyperfine splitting the energy levels revealed 16 isotropic Hfs. The redox reactio
Clumeck N; Hermans P; De Wit S; Department of Internal Medicine, Saint-Pierre University; Hospital, Brussels, Belgium.
Human immunodeficiency virus infection has numerous clinical manifestations and affects patients from a broad spectrum of social, ethical, cultural and psychological backgrounds. As a result the practising physician has to face multiple, recurrent and complicated problems. This review focuses on the means of early dia
Lee MH; Oliver JM; Gillooley JF; Dept of Pathology, St Vincent's Hospital and Medical Center, New; York, NY 10011.
A case of acquired immune deficiency syndrome (AIDS)-related Burkitt s-like lymphoma (BLL), demonstrating an as yet unreported occurrence of intracytoplasmic immunoglobulin inclusions, is reported. Histologic, immunocytochemical, and ultrastructural features are described with a review of the literature on signet-ring
Neurologic complications and cerebrospinal fluid (CSF) abnormalities are common in AIDS. We found that a substantial number of AIDS patients with neurologic involvement had oligoclonal IgG bands in CSF and sera by IEF. Using an IEF-Ag overlay technique, anti-gp120 antibody activity was demonstrated more frequently tha
Merelli E; Sola P; Montagnani G; Baldini E; Department of Neurology, University of Modena, Italy.
Because of the undecided question whether HTLV-related virus antibodies are present in multiple sclerosis (MS), we tested cerebrospinal fluid (CSF) and serum from 52 MS patients and 32 patients affected with other neurological diseases. ELISA procedure was used to detect antibodies against HTLV-I and HIV. Negative res
J Med Vet Mycol. 1988 Feb;26(1):67-71. Unique Identifier : AIDSLINE MED/88244976
Dupont B; Drouhet E; Pasteur Institute Hospital, Paris, France.
Seventy-one patients with oropharyngeal candidosis received treatment with fluconazole given as a single 50 mg capsule once daily. Of these patients 61 were HIV-antibody positive. Candidosis had been present in nearly all patients for a least one month prior to fluconazole treatment. The duration of daily therapy was
Benson MC; Kaplan MS; O'Toole K; Romagnoli M; Department of Urology, Columbia University College of Physicians; and Surgeons, New York, New York.
We report a case of symptomatic cytomegalovirus cystitis associated with the acquired immune deficiency syndrome related complex. The diagnosis of the acquired immune deficiency syndrome was established by bladder biopsy. The hematuria resolved after systemic
Progressive multifocal leukoencephalopathy, a demyelinating disease of the central nervous system, is caused by a polyomavirus. This opportunistic virus is demonstrable in affected brain tissue obtained by biopsy or at autopsy. The disease commonly occurs in immunocompromised patients secondary to lymphoproliferative
Am J Med. 1988 Jun 24;84(6A):87-90. Unique Identifier : AIDSLINE MED/88250275
Mitra G; Dobkin MB; Louie RE; Mozen MM; Cutter Biological of Miles Inc., Berkeley, California 94701.
Alpha-1-proteinase inhibitor concentrates have been prepared from pooled human plasma for therapeutic applications. Pasteurization (60 degrees C, 10 hours) conditions have been defined to reduce risks of transmission of viral agents without significant loss of biologic activity of the purified product. Human clinical
Am J Pathol. 1988 Jun;131(3):490-6. Unique Identifier : AIDSLINE MED/88250346
Keh WC; Gerber MA; Department of Pathology, City Hospital Center, Elmhurst, New; York.
Infection by cytomegalovirus ( CMV ) is a frequent cause of morbidity and mortality in patients with acquired immune deficiency syndrome (AIDS). The authors studied the distribution of CMV in 4 patients with AIDS using a commer
Droge W; Eck HP; Naher H; Pekar U; Daniel V; Institut fur Immunologie und Genetik, Deutsches; Krebsforschungszentrum, Universitat Heidelberg.
The acquired immunodeficiency syndrome (AIDS) is accompanied by a metabolic disturbance. Serum samples from persons with antibodies against the AIDS associated human immunodeficiency virus (HIV/LAV/HTLV III) including persons without overt symptoms, patients with lymphadenopathy syndrome (LAS) and patients with AIDS o
Stepina VN; Seniuta NB; Gurtsevich VE; Mazurin VS; Iakovleva LS
Antibodies to HTLV-1 were detected in sera from 1298 healthy adult persons living in the Far East. It is shown that virus infectivity of the Nigidalts was 8%, Nivkhs--2%, Udegeits--2.9%, Oroches--2.4%, Russians--0.9%. However, the incidence of acute leukemia in these regions is low. It is suggested that these regions
Int J Cancer. 1988 Jun 15;41(6):868-72. Unique Identifier : AIDSLINE MED/88227056
Eguchi T; Kubonishi I; Daibata M; Yano S; Imamura J; Ohtsuki Y; Miyoshi I; Department of Medicine, Kochi Medical School, Japan.
A hamster lymphoid cell line, HCT-2, transformed by human T-cell leukemia virus type I (HTLV-I) was serially transplanted for 9 passages in newborn hamsters. A total of 34 newborn hamsters inoculated intraperitoneally (i.p.) with 0.2-2 X 10(7) HCT-2 cells developed fatal lymphomas with dissemination to various organs
Int J Cancer. 1988 Jun 15;41(6):873-9. Unique Identifier : AIDSLINE MED/88227057
Thomson AW; Forrest EH; Smart LM; Sewell HF; Whiting PH; Davidson RJ; Department of Pathology, University of Aberdeen, Scotland.
Our objective was to examine the effect of cyclosporin A (CsA; 25 or 12.5 mg/kg) on growth of an acute (Roser) T-cell leukaemia in male PVG rats. The leukaemic blasts were shown (by immunocytochemical analysis) to have a mature, T-helper-cell phenotype, i.e., OX-19 (CD5) +/- , W3/25 (CD4)+, OX44+, MHC-class I+, OX-26+
Int J Cancer. 1988 Jun 15;41(6):880-5. Unique Identifier : AIDSLINE MED/88227058
Sabe H; Tanaka A; Siomi H; Koyasu S; Yonehara S; Yahara I; Tagaya Y; Sugie K; Teshigawara K; Yodoi J; et al; Institute for Virus Research, Kyoto University, Japan.
Abnormal expression of the low-affinity receptor for interleukin-2 (IL-2R) is a characteristic of the HTLV-I (+) leukemic T cells in adult T-cell leukemia (ATL). Despite the expression of IL-2R bearing Tac antigen (IL-2R/p55), leukemic cells of the majority of ATL patients do not proliferate in response to IL-2. In th
Seto A; Kawanishi M; Matsuda S; Ogawa K; Miyoshi I; Department of Microbiology, Faculty of Medicine, Kyoto; University.
An HTLV-I-transformed T cell line, obtained from the peripheral blood of a virus-infected (B/J X Chbb:HM) F1 rabbit, was able to kill syngeneic newborn rabbits within 7 days, when inoculated intraperitoneally at a dose of 1 X 10(8) cells. Inoculation of 1 X 10(7) cells killed or rendered moribund 50% of inoculated ani
Frix CD 3d; Bronson DM; Rhee HL; Goldin H; Ringel EW; Department of Medicine, Cook County Hospital, Chicago, IL 60612.
A 56-year-old black man developed a pemphigus foliaceus-like bullous eruption as the initial presentation of chronic T cell lymphocytic leukemia. Histologic examination disclosed superficial acantholysis consistent with pemphigus foliaceus and an infiltrate of atypical lymphoid cells in the papillary dermis. Repeated
Gessain A; Caudie C; Gout O; Vernant JC; Maurs L; Giordano C; Malone G; Tournier-Lasserve E; Essex M; de-The G; Laboratory of Epidemiology and Immunovirology of Tumors, Faculty; of Medicine Alexis Carrel, Neurological Hospital, Lyon, France.
Tropical spastic paraparesis (TSP), a neuromyelopathy predominantly involving the pyramidal tract and commonly observed in tropical and equatorial areas, was recently found to be associated with human T lymphotropic virus type I (HTLV-I). We investigated sera and cerebrospinal fluid (CSF) from 19 patients with TSP who
Tamori S; Uchiyama T; Umadome H; Hori T; Uchino H; Hattori T; Araki K; First Division of Internal Medicine, Faculty of Medicine, Kyoto; University, Japan.
We studied the change in cytoplasmic free calcium ion concentration ([Ca2+]i) in the peripheral blood leukemic cells from adult T-cell leukemia (ATL) patients stimulated by anti-T3 (CD3) or anti-T11 (CD2) antibodies in order to see whether there is an abnormal response in the early activation processes following T3 or
Lancet. 1988 Jun 4;1(8597):1249-52. Unique Identifier : AIDSLINE MED/88231973
Helbert M; Robinson D; Peddle B; Forster S; Kocsis A; Jeffries D; Pinching AJ; Department of Immunology, St Mary's Hospital, London.
In a study of treatment by zidovudine in 106 patients with the acquired immunodeficiency syndrome (AIDS) or AIDS-related complex, an acute meningo-encephalitic illness developed in 4 of 21 patients within 17 days after the dose of zidovudine had had to be reduced because of myelotoxicity. 3 of the 4 patients had previ
Tsujimoto A; Teruuchi T; Imamura J; Shimotohno K; Miyoshi I; Miwa M; Virology Division, National Cancer Center Research Institute,; Tokyo, Japan.
Human T-cell leukemia virus type 1 (HTLV-1) is known to be associated with adult T-cell leukemia (ATL). Recently, HTLV-1-associated myelopathy (HAM) was described as a neurological disease with which an etiological association of HTLV-1 is suspected. A provirus genome was cloned from a lymphoid cell line derived from
Waldmann TA; Tsudo M; Metabolism Branch, National Cancer Institute, Bethesda, MD 20892.
Antigen-induced activation of resting T cells induces the synthesis of interleukin-2 ( IL-2 ), as well as the expression of specific cell surface receptors for this lymphokine. There are at least two forms of the cellular receptors for IL-2, one with a very high affinity
Pesce CD; Ciprani F; D'Onofrio C; Alvino E; Perno CF; Bonmassar E; Calio R; Department of Experimental Medicine and Biochemical Sciences, II; University of Rome, Italy.
In vitro infection of human cord blood lymphocytes (CBL) with human T-cell leukemia/lymphoma virus type I (HTLV-I) was found to be reduced by suramin treatment at a concentration ranging from 10-100 micrograms/ml. At higher concentrations (500 micrograms/ml) suramin was toxic to the cells and even resulted in an incre
Immunol Lett. 1988 May;18(1):15-8. Unique Identifier : AIDSLINE MED/88243246
Andrada-Serpa MJ; Dobbin JA; Gomes P; Linhares D; Azevedo JG; Hendriks J; Clayden SA; Rumjanek VM; Tedder RS; Instituto Nacional de Cancer, Praca da Cruz Vermelha, Rio de; Janeiro, Brazil.
The prevalence of human T lymphotropic virus type I (HTLV-I) and human immunodeficiency virus (HIV) antibodies was evaluated in Brazil among 116 aboriginal Indians living in a pre-Amazonian region, and in 44 patients with haematological malignant disorders being treated in Rio de J
Matsuo T; Tomonaga M; Bennett JM; Kuriyama K; Imanaka F; Kuramoto A; Kamada N; Ichimaru M; Finch SC; Pisciotta AV; et al; Radiation Effects of Research Foundation, Department of Clinical; Studies, Nagasaki.
The concordance rate for diagnoses of atomic bomb-related cases of leukemia in Nagasaki was determined using the French-American-British (FAB) classification for acute leukemias and myelodysplastic syndromes (MDS). Two Radiation Effects Research Foundation (RERF) hematologists and one of the members (JMB) of the FAB c
Kitajima T; Itamura S; Hamakado T; Hatanaka M; Institute for Virus Research, Kyoto University, Japan.
The env-pX IV fused gene of human T-cell leukemia virus type I (HTLV-I) was inserted into lac promoter-directed expression vectors for production of viral proteins in bacteria. Resulting recombinant plasmids, pK13 and pK15, directed synthesis of fused proteins of 59 kDa (Env-p40x) and 100 kDa (Gag-Env-p40x), respectiv
Proc R Soc Lond B Biol Sci. 1988 Apr 22;233(1272):367-77. Unique Identifier : AIDSLINE MED/88248068
Medley GF; Billard L; Cox DR; Anderson RM; Department of Biology, Imperial College, University of London,; U.K.
This paper contains details of methods and full results of estimates of the incubation period of acquired immunodeficiency syndrome (AIDS) that were outlined in a previous paper by Medley et al. (Nature, Lond. 328, 719 (1987)). The original model is modified to assess the influence of age and sex on the incubation per
De Luca CJ; Merletti R; NeuroMuscular Research Center, Boston University, MA 02215.
Surface myoelectric signals were detected from the skin surface above the tibialis anterior muscle, the peroneus brevis muscle, the soleus muscle and the tibial bone during selective maximal electrical stimulation of the tibialis anterior muscle in 12 normal subjects. The double differential technique developed by Bro
A murine monoclonal antibody (MAb), 10E9, has been generated which identifies a conserved and immunodominant epitope of the human immunodeficiency virus (HIV) transmembrane protein, gp41. The MAb reacts with the protein backbone of the mature env gene product and also with polyprotein precursor, gp160. Human sera were
Vonsover A; Gotlieb-Stematsky T; Alexander R; Fogel A; Rubinstein E; Handzel ZT; Burstein R; Bentwich Z; Central Virology Laboratory, Chaim Sheba Medical Center,; Tel-Hashomer, Israel.
Human immunodeficiency virus (HIV 1) strains were isolated from peripheral blood lymphocytes of eight homosexual men (two asymptomatic and six with lymphadenopathy syndrome) and of the wife of an AIDS patient with AIDS-related complex. All except one had antibodies to HIV in their serum. Virus isolation was carried ou
Ogawa R; Koizumi T; Nakao Y; Sakitani M; Watanabe Y; Fujita T; Department of Medicine, Kobe University School of Medicine,; Hyogo.
Antibodies reactive with O-phosphotyrosine (Ptyr) were detected in all of 56 patients with adult T cell leukemia (ATL) with high titers ranging from 1:1,600 to 1:25,000 in 91% of the patients, whereas 97% of 70 healthy subjects showed titers of 1:400 or less. Ptyr-containing proteins (molecular weights of 70k, 45k and
Asjo B; Albert J; Chiodi F; Fenyo EM; Department of Virology, Karolinska Institute Stockholm, Sweden.
We present an improved culture technique for propagation of human immunodeficiency virus (HIV) strains that grow slowly, yield low reverse transcriptase activity and can be transmitted poorly, if at all, to cell lines. By using the Jurkat-tatIII cell line 29 (of 30) of these slow/low HIV strains, including one West Af
Ozols RF; Ihde DC; Linehan WM; Jacob J; Ostchega Y; Young RC; Division of Cancer Treatment, National Cancer Institute,; Bethesda, MD 20892.
We performed a prospective randomized trial of a high-dose chemotherapy regimen v standard cisplatin-based chemotherapy in poor prognosis nonseminomatous germ-cell cancer patients. The high-dose regimen consisting of twice the standard dose of cisplatin (P), along with vinblastine (Ve), bleomycin (B), and the epipodop
Le Grice SF; Zehnle R; Mous J; Central Research Units, F. Hoffmann-LaRoche & Co. Ltd., Basel,; Switzerland.
We have cloned the entire pol gene of human immunodeficiency virus type 2 into a high-level Escherichia coli expression system. Induction of cultures containing the recombinant plasmid, p2RTL1, leads to rapid accumulation of polypeptides of 66, 54, and 34 kilodaltons. We have designated the larger polypeptides reverse
Science. 1988 Jun 3;240(4857):1335-9. Unique Identifier : AIDSLINE MED/88235916
Jameson BA; Rao PE; Kong LI; Hahn BH; Shaw GM; Hood LE; Kent SB; Division of Biology, California Institute of Technology, Pasadena; 91125.
The human immunodeficiency virus type 1 (HIV-1) uses the CD4 protein as a receptor for infection of susceptible cells. A candidate structure for the HIV-1 binding site on the CD4 protein was identified by epitope mapping with a family of eight functionally distinct CD4-specific monoclonal antibodies in conjunction wit
Henin Y; Marechal V; Barre-Sinoussi F; Chermann JC; Morgenthaler JJ; Viral Oncology Unit, Institut Pasteur, Paris, France.
We studied the inactivation of the etiologic agent of the acquired immunodeficiency syndrome, human immunodeficiency virus, in the course of the Kistler and Nitschmann cold ethanol fractionation of human blood plasma. By measuring reverse transcriptase activity and viral infectivity, we have shown that the virus load
Zaman MK; Wooten OJ; Suprahmanya B; Ankobiah W; Finch PJ; Kamholz SL; Brooklyn Veterans Administration Medical Center, New York.
Pneumocystis carinii organisms cluster in alveolar casts. A method for concentrating alveolar casts in sputum specimens might improve the diagnostic usefulness of sputum studies in possible cases of pulmonary infection with Pneumocystis carinii. The use of sputum induction to detect Pneumocystis carinii was studied in
Egerter DA; Beckstead JH; Department of Pathology, University of California, San Francisco; 94143.
An increased incidence of high-grade malignant non-Hodgkin s lymphomas has been reported in homosexual men. This phenomenon appears to represent another facet of the acquired immunodeficiency syndrome (AIDS). Histologically, the majority of these lymphomas have been small noncleaved cell lymphomas or immunoblastic lym
Minasi D; Pellicano S; Calzone R; Foti N; Divisione di Pediatria, Regione Calabria-U.S.L. n. 26, Presidio; Ospedale Civile, Gioia Tauro.
In the light of the international literature and personal observation, the diagnostic techniques employed in Pneumocystis Carinii Pneumonia (PCP), a major opportunistic infection of acquired immunodeficiency syndrome (AIDS) are reviewed.
Proc Natl Acad Sci U S A. 1988 Jun;85(12):4455-9. Unique Identifier : AIDSLINE MED/88248036
Kulaga H; Folks TM; Rutledge R; Kindt TJ; Laboratory of Immunogenetics, National Institute of Allergy and; Infectious Diseases, Bethesda, MD 20892.
We report the successful infection of two rabbit T-cell lines and one rabbit macrophage line with human immunodeficiency virus 1 (HIV-1). One T-cell line was a herpesvirus ateles transformant, the other T-cell line was a human T-cell leukemia virus I transformant, and the macrophage line was a simian virus 40 transfor
Proc Natl Acad Sci U S A. 1988 Jun;85(12):4478-82. Unique Identifier : AIDSLINE MED/88248041
Goudsmit J; Debouck C; Meloen RH; Smit L; Bakker M; Asher DM; Wolff AV; Gibbs CJ Jr; Gajdusek DC; Academic Medical Center, University of Amsterdam, The; Netherlands.
Chimpanzees are susceptible to infection by divergent strains of human immunodeficiency virus type 1 (HIV-1), none of which cause clinical or immunological abnormalities. Chimpanzees were inoculated with one of four strains of HIV-1: human T-lymphotropic virus (HTLV) type IIIB, lymphadenopathy virus (LAV) type 1, HTLV
Proc Natl Acad Sci U S A. 1988 Jun;85(12):4521-5. Unique Identifier : AIDSLINE GENBANK/M20839
Koga Y; Lindstrom E; Fenyo EM; Wigzell H; Mak TW; Ontario Cancer Institute, University of Toronto, Canada.
Infection by human immunodeficiency virus (HIV-1) of a human T leukemia cell line (HUT 78) leads to a rapid accumulation at an elevated level (10- to 20-fold) of heterodisperse RNAs, revealed by their containing repetitive sequences. Sequence data indicate that the repetitive elements (e.g., Alu) are associated with t
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