PATHOLOGY OF AIDS IN CHILDREN NLM AIDSLINE Important note: Information in this article was accurate in 1988. The state of the art may have changed since the publication date.

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PATHOLOGY OF AIDS IN CHILDREN

AIDS, Acquired Immune Deficiency Syndrome, and other Manifestations of HIV Infection. Wormser GP et al, eds. Park Ridge, NJ, Noyes Publications, p. 915-34, 1987.. Unique Identifier : AIDSLINE ICDB/88647014
Joshi VV; Oleske JM; United Hospitals Medical Center, Coll. of Medicine and Dentistry; of New Jersey, Newark, NJ

Abstract: Pathologic information derived from the study of children with acquired immunodeficiency syndrome (AIDS) has contributed much to the understanding of this syndrome. Pathologic changes found in children with AIDS are described based on the study of biopsy and/or autopsy material from 25 children treated at the Children's Hospital of New Jersey. The significance of these pathologic changes with respect to pathogenesis and diagnosis of AIDS involving the thymus, lymph nodes, other lymphoreticular tissues, AIDS encephalopathy, respiratory system lesions, gastrointestinal tract, liver, kidneys, testes, heart, blood vessels, endocrine and musculoskeletal systems, opportunistic infections, extranodal and B-cell lymphoid proliferation, pathogenesis of pathologic lesions in children with AIDS (primary pathologic lesions and associated pathologic lesions), and multinucleated giant cells in tissues of children with AIDS are discussed. The characteristic thymic findings in AIDS played an extremely important role in helping to distinguish AIDS from congenital immunodeficiencies. The discovery of lymphoid interstitial pneumonitis, a process characterized by diffuse alveolar septal infiltrates by the same type of cells as in pulmonary lymphoid hyperplasia, has added an important diagnostic criterion to this syndrome. Clearly, more study of this important area is needed. (44 Refs)
Keywords: Acquired Immunodeficiency Syndrome/*PATHOLOGY Autopsy AIDS-Related Complex/*PATHOLOGY B-Lymphocytes/PATHOLOGY Child Human Lymph Nodes/PATHOLOGY Opportunistic Infections/PATHOLOGY T-Lymphocytes/PATHOLOGY MONOGRAPH REVIEW, TUTORIAL REVIEW

KWDacquiredimmunodeficiencysyndrome/KWDpathologyautopsyaids-relatedcomplex/KWDpathologyb-lymphocytes/pathologychildhumanlymphnodes/pathologyopportunisticinfections/pathologyt-lymphocytes/pathologymonographreview,tutorialreview
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Copyright © 1988 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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