Cell-mediated immunity in the acquired immunodeficiency syndrome. NLM AIDSLINE Important note: Information in this article was accurate in 1988. The state of the art may have changed since the publication date.

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Cell-mediated immunity in the acquired immunodeficiency syndrome.

Braz J Med Biol Res. 1987;20(5):579-82. Unique Identifier : AIDSLINE MED/88252492
de-Araujo AC; Secao de Imunologia, Instituto Adolfo Lutz, Sao Paulo, Brasil.

Abstract: The present study evaluates the in vitro cellular immunity response in cases of suspected Acquired Immunodeficiency Syndrome (AIDS). The immunological features of 111 patients were correlated with those from eleven healthy controls. Patients were divided into three groups: RISK, LAS/ARC and AIDS, using CDC criteria. The AIDS showed leucopenia, lymphopenia, diminished number of T and B lymphocytes, normal number of thermostable E-rosette forming cells (TE), decreased helper-inducer T cell, elevated suppressor-cytotoxic T cell, reversed helper T cell/suppressor T cell ratio and depressed proliferative response using mitogens like phytohemagglutinin (PHA), concanavalin-A (Con-A), pokeweed mitogen (PWM) and purified protein derivative antigen (PPD). These findings confirm a severe deficiency in cellular immunity and permit to establish an immune cellular profile, characteristic of the AIDS patients.
Keywords: Acquired Immunodeficiency Syndrome/*IMMUNOLOGY Adult AIDS-Related Complex/IMMUNOLOGY Comparative Study Human In Vitro Leukocyte Count Leukocytes/CLASSIFICATION Lymphocyte Transformation/DRUG EFFECTS Lymphocytes/CLASSIFICATION Male Middle Age Support, Non-U.S. Gov't JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/KWDimmunologyadultaids-relatedcomplex/immunologycomparativestudyhumaninvitroleukocytecountleukocytes/classificationlymphocytetransformation/drugeffectslymphocytes/classificationmalemiddleagesupport,non-uKWDsKWDgov'tjournalarticle
881030
M88A0641

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