B-cell activation in HIV infection: relationship of spontaneous immunoglobulin secretion to various immunological parameters.

Important note: Information in this article was accurate in 1988. The state of the art may have changed since the publication date.

B-cell activation in HIV infection: relationship of spontaneous immunoglobulin secretion to various immunological parameters.

Clin Exp Immunol. 1988 Mar;71(3):410-6. Unique Identifier : AIDSLINE MED/88253847
Mizuma H; Litwin S; Zolla-Pazner S; Laboratory Service, New York Veterans Administration Medical; Center, New York 10010.

Abstract: Peripheral blood mononuclear cells from HIV-infected individuals spontaneously secrete elevated levels of IgG, IgM and IgD. This increased level of synthesis and secretion is similar in HIV-infected subjects with no or few symptoms, in ARC patients and in AIDS patients. Thus, abnormal B-cell activation is characteristic of patients with mild as well as severe manifestations of HIV infection. The level of spontaneous cellular secretion of IgG, IgM and IgD correlates with serum levels of these isotypes. Levels of spontaneous cellular secretion of IgG and IgM correlate negatively with the percentage but not with the absolute number of T4-positive cells and correlate positively with the percentage but not with the absolute number of T8-positive cells. The data suggest that the proportional distribution of these T-cell subsets is a critical factor in the B-cell dysregulation leading to overproduction of IgG and IgM. On the other hand, spontaneous IgD secretion correlates with neither the percent nor the absolute number of T4 or T8 cells suggesting that the increase of IgD-secretion by B cells is independent of the T-cell defects. The data imply that more than one mechanism underlies the B-cell activation in HIV-infected individuals.

Keywords: Acquired Immunodeficiency Syndrome/*IMMUNOLOGY AIDS-Related Complex/IMMUNOLOGY B-Lymphocytes/*IMMUNOLOGY Cells, Cultured Comparative Study Human IgD/BIOSYNTHESIS IgG/BIOSYNTHESIS IgM/BIOSYNTHESIS Immunoglobulins/*BIOSYNTHESIS Leukocyte Count Lymphocyte Transformation Male Support, Non-U.S. Gov't Support, U.S. Gov't, Non-P.H.S. Support, U.S. Gov't, P.H.S. T-Lymphocytes/IMMUNOLOGY JOURNAL ARTICLE

881030
M88A0272

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