Washington, DC : American Association for the Advancement of Science, c1988 xvi, 478 p. : ill (AAAS publication ; no. 88-19) Unique Identifier : AIDSLINE CAT/8808237
New York : Liss, c1988 xi, 669, vii p. : ill (Cancer detection and prevention, ISSN 0361-090X ; v. 12, no. 1-6) Unique Identifier : AIDSLINE CAT/8808350
Programs, hotlines, legal assistance, medical information, testing sites, and agencies or organizations in the District of Columbia, Northern Virginia, and Maryland. Entries give identification and descriptive information. Index of organizations.
Washington, DC (1620 Eye St., NW, Washington 20006) : The Mayors, [1988] xiii, 133 p Unique Identifier : AIDSLINE CAT/8809279
Listing of organizations providing AIDS-related serivces. Geographical arrangement by states and cities. Entries give identification information of the organization, the contact person, services offered, and kinds of educational materials offered.
AIDS, Acquired Immune Deficiency Syndrome, and other Manifestations of HIV Infection. Wormser GP et al, eds. Park Ridge, NJ, Noyes Publications, 1103 p., 1987.. Unique Identifier : AIDSLINE ICDB/88646995
Anonymous; No affiliation given
Up to March of 1987, two landmark events have occurred in the history of our understanding of AIDS. One is the recognition of the entity as a distinct clinical syndrome. The other is the discovery of the etiologic agents. This book provides a comprehensive overview of the epidemiology and etiologic agent of acquired i
AIDS, Acquired Immune Deficiency Syndrome, and other Manifestations of HIV Infection. Wormser GP et al, eds. Park Ridge, NJ, Noyes Publications, p. 18-35, 1987.. Unique Identifier : AIDSLINE ICDB/88646996
Ward JW; Hardy AM; Drotman DP; AIDS Program, Centers for Disease Control, Atlanta, GA
The first cases of what was later termed the acquired immunodeficiency syndrome (AIDS) were reported to the Centers for Disease Control in the spring of 1981. The patients (pts) were all young, previously healthy homosexual men with similar patterns of opportunistic illnesses due to an unexplained suppression of the i
AIDS, Acquired Immune Deficiency Syndrome, and other Manifestations of HIV Infection. Wormser GP et al, eds. Park Ridge, NJ, Noyes Publications, p. 96-107, 1987.. Unique Identifier : AIDSLINE ICDB/88646997
Ancelle RA; Brunet JB; WHO Collaborating Center on AIDS, Paris, France
Five yr after the first description of the acquired immunodeficiency syndrome (AIDS) in the United States , cases have been reported in about 60 countries on five continents. At present, the epidemiology of AIDS worldwide is difficult to assess due to large gaps in available information
AIDS, Acquired Immune Deficiency Syndrome, and other Manifestations of HIV Infection. Wormser GP et al, eds. Park Ridge, NJ, Noyes Publications, p. 108-27, 1987.. Unique Identifier : AIDSLINE ICDB/88646998
Biggar RJ; Agius G; International AIDS Epidemiology, NCI, Bethesda, MD
Acquired immunodeficiency syndrome (AIDS) is now widely recognized to be an important public health problem in many parts of central and eastern Africa. AIDS in sub-Saharan Africa is discussed, including initial recognition of the AIDS problem, serologic considerations, epidemiology of human immunodeficiency virus (HI
AIDS, Acquired Immune Deficiency Syndrome, and other Manifestations of HIV Infection. Wormser GP et al, eds. Park Ridge, NJ, Noyes Publications, p. 160-85, 1987.. Unique Identifier : AIDSLINE ICDB/88647000
Olsen RG; Lafrado LJ; Lewis MG; Mathes LE; Haffer K; Sharpee R; Comprehensive Cancer Center, Ohio State Univ., Columbus, OH
Retrovirus-induced acquired immune deficiency has been recognized in numerous animal virus systems for more than a decade. These animal retroviruses, including feline leukemia virus (FeLV), murine leukemia virus, and avian leukosis virus have, as common outcomes of infection, a loss of immune competence and induction
AIDS, Acquired Immune Deficiency Syndrome, and other Manifestations of HIV Infection. Wormser GP et al, eds. Park Ridge, NJ, Noyes Publications, p. 186-249, 1987.. Unique Identifier : AIDSLINE ICDB/88647001
Shortly after the technology to grow human T cells became available in 1976, the first key experiments to develop long-term cultures of human neoplastic T cells were conducted, leading, in turn, to the isolation of the first human retroviruses. The characteristics of human T lymphotropic viruses (HTLVs), their disease
AIDS, Acquired Immune Deficiency Syndrome, and other Manifestations of HIV Infection. Wormser GP et al, eds. Park Ridge, NJ, Noyes Publications, p. 304-30, 1987.. Unique Identifier : AIDSLINE ICDB/88647002
Siegal FP; Dept. of Medicine, Long Island Jewish Medical Center, New Hyde; Park, NY
Human immunodeficiency virus (HIV) infection leads to profound alterations within the immune system at many levels. Most of the clinical syndromes associated with HIV are known to be opportunistic, because of their occurrence in patients with primary and secondary immune deficiencies before the advent of acquired immu
AIDS, Acquired Immune Deficiency Syndrome, and other Manifestations of HIV Infection. Wormser GP et al, eds. Park Ridge, NJ, Noyes Publications, p. 331-46, 1987.. Unique Identifier : AIDSLINE ICDB/88647003
Cunningham-Rundles S; Bedford R; Metroka CE; Div. of Pediatric Hematology/Oncology, New York Hosp.-Cornell; Medical Center, New York, NY
When the present pandemic of the acquired immune deficiency syndrome (AIDS) was first described in 1981, leukopenia and lymphopenia were reported as predominant laboratory findings in patients with opportunistic infections. During the past 7 yr of study on T-cell immunity in AIDS, emphasis has shifted from concepts of
AIDS, Acquired Immune Deficiency Syndrome, and other Manifestations of HIV Infection. Wormser GP et al, eds. Park Ridge, NJ, Noyes Publications, p. 347-66, 1987.. Unique Identifier : AIDSLINE ICDB/88647004
Volsky DJ; Lai PK; Molecular Biology Lab., Univ. of Nebraska Medical Center, Omaha,; NE
The acquired immunodeficiency syndrome (AIDS) is characterized by severe abnormalities at virtually every level of the immune system, including defects in T lymphocyte function, altered B cell and monocyte activity, and various abnormalities of humoral immunity. B-cell abnormalities in AIDS-related conditions, and the
AIDS, Acquired Immune Deficiency Syndrome, and other Manifestations of HIV Infection. Wormser GP et al, eds. Park Ridge, NJ, Noyes Publications, p. 367-79, 1987.. Unique Identifier : AIDSLINE ICDB/88647005
Cunningham-Rundles S; Div. of Pediatric Hematology/Oncology, The New York Hosp.-Cornell; Medical Center, New York, NY
The hallmark of the acquired immunodeficiency syndrome (AIDS) is the loss of cellular immune function. This single characteristic provided the original clue which led to the realization that destruction of the immune system was central to the development and evolution of the various opportunistic infections and tumors
AIDS, Acquired Immune Deficiency Syndrome, and other Manifestations of HIV Infection. Wormser GP et al, eds. Park Ridge, NJ, Noyes Publications, p. 408-44, 1987.. Unique Identifier : AIDSLINE ICDB/88647006
Garay SM; Dept. of Medicine, New York Univ. Sch. of Medicine, New York, NY
Many of the pulmonary infections seen in patients (pts) with acquired immunodeficiency syndrome (AIDS) represent endogenous reactivation of previously dormant organisms, which are unmasked by the defect in cellular immunity. Pulmonary manifestations of AIDS are discussed, with emphasis on diagnosis and treatment. A ge
AIDS, Acquired Immune Deficiency Syndrome, and other Manifestations of HIV Infection. Wormser GP et al, eds. Park Ridge, NJ, Noyes Publications, p. 478-517, 1987.. Unique Identifier : AIDSLINE ICDB/88647007
Yarrish RL; Dept. of Medicine, New York Medical Coll., Valhalla, NY
Infection with human cytomegalovirus ( CMV ) is extremely common in all populations, but transmission of infection seems to be particularly intense among sexually active homosexual men. In immunocompetent individuals, CMV may c
AIDS, Acquired Immune Deficiency Syndrome, and other Manifestations of HIV Infection. Wormser GP et al, eds. Park Ridge, NJ, Noyes Publications, p. 548-78, 1987.. Unique Identifier : AIDSLINE ICDB/88647008
Koppel BS; Dept. of Neurology, Metropolitan Hosp. Center, New York, NY
Neurological complications are common in acquired immune deficiency syndrome (AIDS). CNS involvement is reported in 80-95% of autopsied cases and 40% of AIDS patients (pts) have symptoms during life. Pathophysiological considerations, clinical syndromes (subacute encephalitis, focal cerebral syndromes, and meningitis)
AIDS, Acquired Immune Deficiency Syndrome, and other Manifestations of HIV Infection. Wormser GP et al, eds. Park Ridge, NJ, Noyes Publications, p. 736-46, 1987.. Unique Identifier : AIDSLINE ICDB/88647009
Ahmed T; Dept. of Medicine, New York Medical Coll., Valhalla, NY
Immunosuppression, due to many causes, has been associated with the occurrence of malignancies, especially lymphoma. Acquired immunodeficiency syndrome (AIDS) is characterized by the appearance of a serious opportunistic infection, Kaposi s sarcoma, primary brain lymphoma, or non-Hodgk
AIDS, Acquired Immune Deficiency Syndrome, and other Manifestations of HIV Infection. Wormser GP et al, eds. Park Ridge, NJ, Noyes Publications, p. 747-66, 1987.. Unique Identifier : AIDSLINE ICDB/88647010
Hymes KB; Dept. of Medicine, New York Univ. Sch. of Medicine, New York, NY
Kaposi s sarcoma (KS) has acquired new importance since the appearance of the acquired immunodeficiency syndrome (AIDS). This tumor, which in the US and Europe previously affected a very small number of elderly patients (pts) with moderate morbidity and mortality, has become a significant cause of illness and death am
AIDS, Acquired Immune Deficiency Syndrome, and other Manifestations of HIV Infection. Wormser GP et al, eds. Park Ridge, NJ, Noyes Publications, p. 838-66, 1987.. Unique Identifier : AIDSLINE ICDB/88647012
Stahl RE; Dept. of Pathology, New York Medical Coll., Valhalla, NY
The acquired immunodeficiency syndrome (AIDS) is associated with a variety of morphologic lesions which are neither specific nor diagnostic of AIDS or human immunodeficiency virus (HIV) infection, but which are characteristic of the disease. The pathologic features include lymphadenopathy and thymic abnormalities, man
AIDS, Acquired Immune Deficiency Syndrome, and other Manifestations of HIV Infection. Wormser GP et al, eds. Park Ridge, NJ, Noyes Publications, p. 867-88, 1987.. Unique Identifier : AIDSLINE ICDB/88647013
Wood GS; Veterans Administration Medical Center, Stanford Univ. Medical; Center, Palo Alto, CA
Human immunodeficiency virus (HIV) infection can be asymptomatic, result in the persistent generalized lymphadenopathy syndrome (PGL) or other manifestations of AIDS-related complex, or result in AIDS. The variable clinical features of PGL and AIDS are reflected by the broad spectrum of histopathologic and immunohisto
AIDS, Acquired Immune Deficiency Syndrome, and other Manifestations of HIV Infection. Wormser GP et al, eds. Park Ridge, NJ, Noyes Publications, p. 915-34, 1987.. Unique Identifier : AIDSLINE ICDB/88647014
Joshi VV; Oleske JM; United Hospitals Medical Center, Coll. of Medicine and Dentistry; of New Jersey, Newark, NJ
Pathologic information derived from the study of children with acquired immunodeficiency syndrome (AIDS) has contributed much to the understanding of this syndrome. Pathologic changes found in children with AIDS are described based on the study of biopsy and/or autopsy material from 25 children treated at the Children
de-Araujo AC; Secao de Imunologia, Instituto Adolfo Lutz, Sao Paulo, Brasil.
The present study evaluates the in vitro cellular immunity response in cases of suspected Acquired Immunodeficiency Syndrome (AIDS). The immunological features of 111 patients were correlated with those from eleven healthy controls. Patients were divided into three groups: RISK, LAS/ARC and AIDS, using CDC criteria. T
Boll Ist Sieroter Milan. 1987;66(6):440-7. Unique Identifier : AIDSLINE MED/88269218
Maiello A; Zotti C; Moiraghi Ruggenini A; Ferrante P; Castellani P; Garetto G; Istituto di Igiene, Universita di Torino.
In this study serum samples from foreign students, temporally living in Turin, coming from Asia, Central and South America and Africa, have been examined by ELISA test, to detect HIV antibodies; positive samples were confirmed by Western blot and indirect immunofluorescence assay. Particular care has been dedicated to
Boll Ist Sieroter Milan. 1987;66(6):448-52. Unique Identifier : AIDSLINE MED/88269219
Cherchi GB; Mura MS; Calia MG; Gakis C; Ginanneschi R; Zara GM; Flumene A; Andreoni G; Istituto di Malattie Infettive dell'Universita di Sassari.
The prevalence of anti HIV antibodies was investigated in the sera of 150 drug addicts and of 62 patients not drug addicts hospitalized in the Institute of Infectious diseases of the University of Sassari in the years 1980-86. No seropositivity was detected in not drug addicts patients in the years of observation and
Boll Ist Sieroter Milan. 1987;66(6):453-5. Unique Identifier : AIDSLINE MED/88269220
Stagni G; Francisci D; Pegiati R; Baldelli F; Istituto di Clinica delle Malattie Infettive, Universita degli; Studi di Perugia.
The Authors studied anti-HTLV III antibodies prevalence in jailed people of Perugia jail. Out of 207 healthy subjects, 10.6% were positive to anti-HTLV III. Prevalence in drug abusers (27.5%) was not apparently different from that observed in a control population of addicts who lived in the community. Prevalence in pr
Donovan RM; Bush CE; Peterson WR; Parker LH; Cohen SH; Jordan GW; Vanden Brink KM; Goldstein E; Department of Internal Medicine, University of California, Davis; 95616.
Simple and sensitive methods to directly detect the human immunodeficiency virus (HIV) are needed for routine use in the clinical laboratory. In this study, we compared DNA probes prepared by: (1) nick translation with biotinylated dATP; (2) direct covalent biotinylation with photobiotin; (3) direct covalent reaction
Nakamura K; Yoshida Y; Ando T; Yamazaki K; Ohnuki N; Ito T; Yano K; Sekine S; Hayashi Y; Sinkai T; et al; Department of Microbiology, Tokyo Metropolitan Research; Laboratory of Public Health.
The serum antibodies to human immunodeficiency virus types 1 (HIV-1) and 2 (HIV-2) were examined for among individuals who visited health centers in Tokyo. Of 8,198 sera screened, one was true-positive and 37 false-positive for HIV-1 antibodies. These 37 false-positives and 305 sera from the population groups at risk
Boll Ist Sieroter Milan. 1987;66(6):471-8. Unique Identifier : AIDSLINE MED/88269223
Uberti Foppa C; Franzetti F; Negri C; Novati R; Cinque P; Privitera G; Parente F; Crocchiolo P; Lazzarin A; Clinica delle Malattie Infettive, Universita degli Studi di; Milano.
Phagocytic and fungicidal activity towards C. albicans spores were tested in 9 patients with AIDS-Related Complex (ARC), but without Candida infections, and in 13 patients with AIDS and deep candidiasis. No significant differences were observed between the two mentioned groups as far as PMN s phagocytosis and killing
McWhorter WP; Division of Cancer Prevention and Control, National Cancer; Institute, Bethesda, Maryland 20892-4200.
The First National Health and Nutrition Examination Survey (NHANESI), conducted in 1971-1975, included a cohort of 6913 adults for whom history of smoking, allergies, and other factors was obtained. These persons were traced (with 93% success) approximately 10 years later by the NHANESI Epidemiologic Followup Survey,
Ferreira A; Villar ML; Alvarez Cermeno JC; Revilla Y; Garcia Rodriguez MC; Fontan G; Gonzalez-Porque P; Unidad de Immunologia, Ciudad Sanitaria La Paz, Madrid, Spain.
A solid-phase enzyme immunoassay (ELISA) has been used to quantify human soluble Class I histocompatibility antigens in serum samples from voluntary blood donors and AIDS patients. Statistical analysis of the results showed significantly raised levels (p less than 0.01) of free HLA Class I in sera from AIDS patients (
Weingarten JS; Huang DY; Jackman JD Jr; Department of Internal Medicine, University of Texas Health; Science Center, Dallas.
Infection with Rhodococcus equi has been reported as an occasional cause of cavitary pneumonia in severely immunocompromised patients, including those with the acquired immunodeficiency syndrome (AIDS). We report two cases of R equi pneumonia presenting in one month in patients infected with human immunodeficiency vir
In the third quarter of 1987 a questionnaire was sent to 350 consecutive patients of a general practice for the purpose of ascertaining patients willingness to be tested (if desired, anonymously) without charge for antibodies against human immunodeficiency virus (HIV). They were asked, among other questions, about th
Winzer M; Gilliar U; Klinik fur Dermatologie und Venerologie der Medizinischen; Universitat zu Lubeck.
We studied biopsy specimens from ten male Caucasian patients with oral hairy leukoplakia. All patients either had the acquired immunodeficiency syndrome (AIDS) or showed symptoms of the AIDS related complex (ARC). On the basis of the specimens studied, we describe the histopathological features of this new entity and
We report the occurrence of mucous membrane manifestations in six patients with HIV-infections: Kaposi sarcomas of the hard palate, of the gingiva, of the larynx and of the glans penis, unusual spreading of condylomata acuminata, bowenoid papulosis, thrush and hairy leukoplakia
Kentzer EJ; Cottingham LS; Smallidge RL; Purdue University, Department of Biochemistry, West Lafayette, IN; 47907.
Amprolium is extracted with methanol-water (2 + 1) containing 5mM dioctylsulfosuccinate (DOSS) and 10mM CaCl2. The analyte is separated from coextracted materials by isocratic ion-pair reverse-phase liquid chromatography, following removal of late-eluting materials on an acid alumina cleanup column, and is detected at
Nakashima H; Tanabe A; Tochikura TS; Yamamoto N; Department of Virology and Parasitology, Yamaguchi University; School of Medicine, Japan.
Cocultivation of MOLT-4 and MOLT-4/HIVHTLV-IIIB cells induces syncytium formation very efficiently and is an appropriate model for evaluation of various substances which might inhibit human immunodeficiency virus (HIV)-induced multinucleated giant cell formation in vitro. We attempted here to quantify the grade of the
Shanson DC; Dryden MS; St Stephen's Hospital, London.
A variety of blood culture media were compared to determine the optimal method for the isolation of Mycobacterium avium-intracellulare (MAI) from the blood of patients with AIDS. Simulated laboratory blood cultures and clinical blood cultures were tested. Glucose broth, Bactec aerobic medium, Kirschner s medium, and B
Palmer E; Martin ML; Goldsmith C; Switzer W; Division of Viral Diseases, Centers for Disease Control, Atlanta,; Georgia 30333.
The ultrastructure of human immunodeficiency virus type 2 (HIV-2) was determined by negative stain and thin section electron microscopy (EM). Some virus particles had surface projections about 10 nm in length which were evenly spaced. Nonidet P40-treated particles which were penetrated by stain revealed a distinctive
A patient with positive serological HIV-II reactions is presented, who lived for many years in North and West Africa and on the Arabian peninsula, and who developed asthenica, incontinence, gait disturbances, impaired mental function, personality changes and finally spastic paraplegia and
Connor E; Gupta S; Joshi V; DiCarlo F; Offenberger J; Minnefor A; Uy C; Oleske J; Ende N; Department of Pediatrics, Children's Hospital of New Jersey,; Newark 07107.
Five children with acquired immunodeficiency syndrome (AIDS) and clinically significant renal disease had detailed pathologic examination of renal tissue (biopsy specimens, autopsy specimens, or both). All patients had proteinuria, hypoalbuminemia, and edema; one patient had persistent azotemia. In two cases, renal di
J Med Educ. 1988 Jul;63(7):522-30. Unique Identifier : AIDSLINE MED/88259181
Johnson JA; Sellew JF; Campbell AE; Haskell EG Jr; Gay AA Jr; Bell BJ; Eastern Virginia Area Health Education Centers Program, Medical; College of Hampton Roads, Norfolk.
In the spring of 1987, 20 medical students from the Eastern Virginia Medical School of the Medical College of Hampton Roads were involved in a pilot program to teach about the acquired immune deficiency syndrome (AIDS) to high school senior students in Norfolk, Virginia. The medical students received instruction about
Knobler EH; Silvers DN; Fine KC; Lefkowitch JH; Grossman ME; Department of Dermatology, College of Physicians and Surgeons,; Columbia University, Columbia-Presbyterian Medical Center, New; York.
We report four patients with antibodies to human immunodeficiency virus and/or acquired immunodeficiency syndrome who were noted to have unique vascular lesions that clinically resembled Kaposi s sarcoma or pyogenic granulomas. The lesions were asymptomatic erythematous-violaceous papules and nodules. They erupted ove
Shugar JM; Som PM; Jacobson AL; Ryan JR; Bernard PJ; Dickman SH; Department of Otolaryngology, Mount Sinai Medical Center, CUNY.
Patients with AIDS or ARC may present with parotid gland enlargement either initially or during the course of their disease. Of nine such patients, eight had unilateral gland enlargement, and one had bilateral disease. CT and MR scanning revealed that all patients except one had bilateral multiple intraparotid cysts.
Yokoyama S; Chung L; Gojobori T; University of Illinois, Urbana-Champaign, Illinois 61820.
A phylogenetic tree for different human immunodeficiency viruses type 1 (HIV1) and type 2 (HIV2), lentiviruses, and oncoviruses has been constructed by comparing the nucleotide sequences of the two regions of their pol genes that encode the reverse transcriptase and endonuclease/integrase. The analysis indicates that
Feng S; Holland EC; Department of Biochemistry, Stanford University Medical Center,; California 94305.
Human immunodeficiency virus (HIV-1) is the primary retroviral agent responsible for AIDS and related disorders worldwide. One of its identified gene products, tat protein, stimulates in trans the expression of all HIV-1 genes by several orders of magnitude. Cells infected with HIV-1 require tat protein to produce vir
Berger JR; Mucke L; Department of Neurology, University of Miami School of Medicine,; FL 33136.
Two human immunodeficiency virus seropositive patients with progressive multifocal leukoencephalopathy (PML) exhibited a dramatic though incomplete recovery of neurologic function and have survived for more than 30 months since the onset of symptoms. PML was the initial manifestation of the acquired immune deficiency
Pediatr Ann. 1988 May;17(5):319-21. Unique Identifier : AIDSLINE MED/88262327
Oleske JM; Connor EM; Boland MG; Division of Pediatric Allergy, Immunology and Infectious; Diseases, University of Medicine and Dentistry, New Jersey; Medical School, Newark 07103.
Pediatr Ann. 1988 May;17(5):341-5. Unique Identifier : AIDSLINE MED/88262330
Desposito F; McSherry GD; Oleske JM; Department of Pediatrics, University of Medicine and Dentistry of; New Jersey, New Jersey Medical School, Newark 07103.
The medical community needs to ensure safety of blood and blood products. Blood bankers have instituted rigid criteria for exclusion of potential donors in high risk categories. Institution of HIV testing would appear to make blood products safer although the complete elimination of HIV contaminated blood and blood pr
Bel-Hadj-Ali Z; Dufour V; Najean Y; Service de Medecine Nucleaire, Hopital Saint-Louis, Paris,; France.
In the last 2 years, 46 cases of HIV-induced pure thrombocytopenias have been studied, using either autologous 111 In-labeled platelets and/or homologous 51Cr-labeled platelets. The most interesting data seem to be: more than 50% of the cases were observed in young, drug addicts, a population statistically different f
Le SY; Chen JH; Braun MJ; Gonda MA; Maizel JV; Division of Cancer Biology and Diagnosis, National Cancer; Institute, Frederick, MD 21701.
The stability of potential RNA stem-loop structures in human immunodeficiency virus isolates, HTLV-III and ARV, has been calculated, and the relevance to the local significant secondary structures in the sequence has been tested statistically using a Monte Carlo simulation method. Potentially significant structures ex
George RB; Department of Medicine, Louisiana State University Medical; Center, Shreveport 71130-3932.
The pathogenic and opportunistic fungi that commonly infect the human respiratory system cause diseases such as histoplasmosis, blastomycosis, aspergillosis, and invasive candidiasis. The increase in the incidence and severity of mycotic infections due to more aggressive immunosuppressive therapy and the spread of acq
Brorsson B; Herlitz C; Department of Social Medicine, Uppsala University, Sweden.
Questionnaire surveys concerning awareness, attitudes and beliefs about HIV virus and AIDS in Sweden were conducted in March/April of 1986, February/March of 1987, and May 1987. The number of individuals compared in the three surveys were 2,622, 1,805 and 707 respectively. The surv
Scott Med J. 1988 Feb;33(1):215. Unique Identifier : AIDSLINE MED/88264381
Forsyth JS; Sharp RA; Ghosh S; Department of Paediatrics, Haematology, Ninewells Hospital and; Medical School, Dundee.
A one-year-old child who presented with thrombocytopaenia was found to be HIV positive and has now developed persistent generalised lymphadenopathy (PGL).
Henderson LE; Sowder RC; Copeland TD; Benveniste RE; Oroszlan S; Bionetics Research, Inc., National Cancer Institute, Frederick,; MD 21701.
A protein designated p14 was purified from a simian immunodeficiency virus (SIVMne) and was shown by amino acid sequence analysis to be nearly identical to the predicted translational product of a unique open reading frame (X-ORF) in the nucleotide sequences of SIVmac and human immunodeficiency virus type 2 (HIV-2). T
Looney DJ; Fisher AG; Putney SD; Rusche JR; Redfield RR; Burke DS; Gallo RC; Wong-Staal F; Department of Viral Diseases, Walter Reed Army Institute of; Research, Washington, DC 20307.
In a study of the immunologic significance of the genetic diversity present within single isolates of human immunodeficiency virus type 1 (HIV-1), the neutralization of viruses derived from molecular clones of the HIV-1 strain HTLV-IIIB by an extensive panel of sera was compared. Sera from HIV-1-infected patients and
Ward JW; Kleinman SH; Douglas DK; Grindon AJ; Holmberg SD; Centers for Disease Control, Center For Infectious Diseases AIDS; Program, Atlanta, Georgia.
From March 1985 through July 1986, blood donors who were positive for antibody to human immunodeficiency virus (HIV) were evaluated at three major blood centers in the United States . Of 818,629 donations, 450 (0.05%) were HIV antibody-positive. The seroprevalence decreased from 0.07 to
Anderson BV; Tomasulo PA; Florida International University, Medical Laboratory Sciences; Department, Miami.
A questionnaire was distributed to 509 AABB institutional members to evaluate current autologous transfusion practices. Results were returned from 47 blood centers, 108 transfusion services and 64 hospital blood banks (response rate 43%). Results indicate that not all eligible patients are allowed to donate due to unn
Taaning E; Scheibel E; Laursen B; Ingerslev J; Department of Clinical Immunology, Glostrup Hospital, Copenhagen,; Denmark.
Abnormal amounts of platelet-associated immunoglobulins (PAIg) and seropositivity for HIV were demonstrated in 18 haemophiliacs suffering from thrombocytopenia of varying severity. Among 34 non-thrombocytopenic haemophiliacs seropositivity for HIV was found in association with increased levels of PAIg in 18 patients,
Carbone LG; Bendixen B; Appel GB; Department of Medicine, Columbia University, College of; Physicians and Surgeons, New York 10032.
A 45-year-old man with the Acquired Immunodeficiency Syndrome (AIDS) and CNS toxoplasmosis presented with acute renal failure, hematuria, and renal colic shortly after starting treatment with sulfadiazine. Ultrasound examination of his kidneys was suggestive of intraparenchymal crystallization of sulfadiazine. His ren
Am J Public Health. 1988 Aug;78(8):944-8. Unique Identifier : AIDSLINE MED/88267349
Osmond D; Bacchetti P; Chaisson RE; Kelly T; Stempel R; Carlson J; Moss AR; San Francisco General Hospital, CA 94110.
We interviewed, and tested for HIV antibody, 117 homosexual men who had been regular sexual partners of men who developed acquired immunodeficiency syndrome (AIDS); 85 tested seropositive. Receptive anal intercourse with the index AIDS case and number of different sexual partners with whom subjects were anally recepti
Am J Public Health. 1988 Aug;78(8):953-7. Unique Identifier : AIDSLINE MED/88267351
Cleary PD; Singer E; Rogers TF; Avorn J; Van Devanter N; Soumerai S; Perry S; Pindyck J; Department of Social Medicine and Health Policy, Division on; Aging, Harvard Medical School, Boston, MA 02115.
This paper describes the sociodemographic and behavioral characteristics of 173 blood donors who were confirmed by Western blot tests to have antibodies to human immunodeficiency virus (HIV), the etiologic agent for acquired immunodeficiency syndrome (AIDS). Seropositive donors were predominantly young, unmarried, and
Am J Public Health. 1988 Aug;78(8):969-70. Unique Identifier : AIDSLINE MED/88267355
Seage GR 3d; Landers S; Mayer KH; Barry MA; Lamb GA; Epstein AM; Community Infectious Disease Epidemiology Program, Boston; Department of Health and Hospitals, MA 02118.
A cost-of-illness study July 1, 1984-June 30, 1985 evaluating 28 patients with AIDS-Related Complex (ARC) and/or Generalized Lymphadenopathy Syndrome (GLS) found the average cost to be $489 per patient per year. None of the ARC or GLS patients in our study was hospitalized during the one year period, and none progress
Ann Intern Med. 1988 Aug 1;109(3):190-3. Unique Identifier : AIDSLINE MED/88267627
Karpatkin S; Nardi MA; Hymes KB; New York University Medical Center, New York.
We report four cases of immunologic thrombocytopenic purpura related to human immunodeficiency virus (HIV) transmitted through heterosexual contact in persons who were not homosexual, addicted to intravenous narcotic drugs, or hemophilic. Each transmission occurred in a different setting. A 23-year-old white woman had
Ann Intern Med. 1988 Aug 1;109(3):194-7. Unique Identifier : AIDSLINE MED/88267628
Leaf AN; Laubenstein LJ; Raphael B; Hochster H; Baez L; Karpatkin S; New York University School of Medicine, New York.
The cases of 14 patients with thrombotic thrombocytopenic purpura admitted to one institution after 1980 were reviewed. Three of the fourteen cases occurred in patients with the acquired immunodeficiency syndrome (AIDS)-related complex and one occurred in a patient with probable human immunodeficiency virus (HIV) infe
Ann Intern Med. 1988 Aug 1;109(3):209-12. Unique Identifier : AIDSLINE MED/88267631
Nair JM; Bellevue R; Bertoni M; Dosik H; Interfaith Medical Center, State University of New York, Health; Science Center, Brooklyn.
Immune thrombocytopenia has been reported with increased incidence in high-risk persons such as intravenous drug addicts and homosexual men who have serologic evidence of infection with human immunodeficiency virus (HIV). Thrombotic thrombocytopenic purpura, generally regarded as a rare disorder, has also been seen in
Ann Med Psychol (Paris). 1988 Mar;146(3):202-4. Unique Identifier : AIDSLINE MED/88267653
Koupernik C
On the basis of information gathered from media the writer delineates the following aspects of the impact of AIDS upon social life: advertising the danger, sex education of the youth, purposeful contamination by AIDS-patients, legal repressive measures, the doctors and the right to test, Anglican Church and acceptance
Ann Neurol. 1988 May;23(5):519-22. Unique Identifier : AIDSLINE MED/88267980
Jones HR Jr; Ho DD; Forgacs P; Adelman LS; Silverman ML; Baker RA; Locuratolo P; Department of Neurology, Lahey Clinic Medical Center, Burlington,; MA 01805.
A case of acute human immunodeficiency virus (HIV) infection manifested by a rapidly fulminating, necrotizing, demyelinating encephalopathy that led to brain death in 5 days is reported. Autopsy demonstrated predominant white matter lesions, acute neuronal damage, and scanty cellular response. Cultures of cerebrospina
Dormont D; Vaslin B; Dubeaux D; Boussin F; Maillard F; Deslys JP; Centre de Recherches, Service de Sante des Armees, Clamart,; France.
Since human immunodeficiency virus (HIV) has been found in the brains of AIDS patients, the possibility was investigated that preparations of human growth hormone (hGH) extracted from human pituitary glands harbor infectious HIV. It was found that the procedure used for extracting hGH, i.e. a combination of acid pH an
Rao TK; Friedman EA; Department of Medicine, State University of New York, Brooklyn; 11203.
Renal syndromes associated with the Acquired immunodeficiency syndrome include: potentially reversible acute renal failure, AIDS associated nephropathy which leads to end stage renal disease, and AIDS developing in patients who are being treated by maintenance hemodialysis. The longitudinal study of 95 patients with A
Jarvik JG; Hesselink JR; Kennedy C; Teschke R; Wiley C; Spector S; Richman D; McCutchan JA; Department of Radiology, University of California, San Diego; 92103.
Magnetic resonance brain scans of 30 patients with either acquired immunodeficiency syndrome (AIDS) or AIDS-related complex were reviewed. Twenty patients had focally abnormal neurological examination results at the time of scanning. Pathological diagnosis was available in nine. Four patterns of abnormality were obser
Aviat Space Environ Med. 1988 Jun;59(6):575-8. Unique Identifier : AIDSLINE MED/88268700
Stambovsky JM; USAF Clinic Ramstein, Ramstein Air Base, Federal Republic of; Germany.
Total force screening in a clinic environment presents many challenges. USAF Clinic Ramstein began total force screening for Human Immunodeficiency Virus (HIV) in August 1986 with a monthly quota of 456 specimens. This paper describes the challenges of instituting this program with existing clinic resources. Methods o
Cancer. 1988 Aug 1;62(3):616-9. Unique Identifier : AIDSLINE MED/88270333
Cappell MS; Yao F; Cho KC; Department of Medicine, Albert Einstein College of Medicine,; Bronx, New York.
Colonic adenocarcinoma developed in an intravenous drug abuser with the acquired immune deficiency syndrome (AIDS) that was diagnosed by the presence of antibodies to the human immunodeficiency virus (HIV), generalized lymphadenopathy, and biopsy proven esophageal candidiasis. The colon cancer presented atypically at
Miller SJ; Division of Dermatology, University of California, School of; Medicine, San Diego 92103.
A hemophiliac man who tested positive for the human immunodeficiency virus presented with facial lesions resembling molluscum contagiosum as the initial manifestation of systemic cryptococcal infection. Widespread molluscum contagiosum is being seen with increasing frequency in patients who have been exposed to the hu
We investigated the incidence, clinical and immunological characteristics of human immuno-deficiency virus (HIV) infection in a group of multi-transfused patients with thalassaemia major who were exposed to transfusion-associated HIV infection. Seropositivity to HIV by Western blot and immunofluorescence analysis was
Doble N; Shaw R; Rowland-Hill C; Lush M; Warnock DW; Keal EE; Department of Chest Medicine, St Mary's Hospital, London, UK.
This study assessed the potential pharmacokinetic interaction between rifampicin and ketoconazole, two drugs used to treat the increasingly common combination of Mycobacterium tuberculosis and Candida albicans infection in AIDS patients. The peak plasma rifampicin concentrations in six healthy male subjects were not a
Kiprov D; Pfaeffl W; Parry G; Lippert R; Lang W; Miller R; Department of Medicine, Children's Hospital, San Francisco,; California 94118.
Peripheral neuropathy is increasingly recognized in patients with AIDS as well as AIDS-related complex (ARC). Thirty homosexual men with polyneuropathy were evaluated in this study. Twenty-one had ARC and nine had AIDS. We observed three distinct clinical syndromes: distal sensorimotor polyneuropathy, chronic inflamma
Alterman DD; Cho KC; Department of Radiology, Albert Einstein College of Medicine,; Bronx, NY 10461.
The anatomy and pathology of the greater omentum as demonstrated by CT has been well described. Approximately 80% of cases of omental pathology are caused by malignancy and the remaining 20% are the result of inflammatory disease, mainly tuberculosis or pancreatitis. Histoplasmosis has not been previously reported to
Baroldi G; Corallo S; Moroni M; Repossini A; Mutinelli MR; Lazzarin A; Antonacci CM; Cristina S; Negri C; Institute of Biomedical Science, Medical School, University of; Milan, Sacco Hospital, Italy.
In 26 consecutive cases with acquired immunodeficiency syndrome (AIDS) the main cardiac findings were Kaposi s sarcoma in 2 cases, microfocal myocardial abscess in 1, subendocardial infarct necrosis in 2, contraction band necrosis in 13, lymphocytic myocarditis in 9, intramyocardial lymphocytic infiltrates without myo
Tuomanen E; Pollack H; Parkinson A; Davidson M; Facklam R; Rich R; Zak O; Rockefeller University, New York, New York 10021.
A pneumococcal isolate that caused relapsing meningitis in a patient infected with human immunodeficiency virus (HIV) was found to display an unusual response to penicillin--rapid death but a striking lack of cellular lysis. This lytic defect was also detected in all four pneumococcal isolates from three additional HI
IMA J Math Appl Med Biol. 1988;5(1):1-19. Unique Identifier : AIDSLINE MED/88274155
Blythe SP; Anderson RM; Department of Pure and Applied Biology, Imperial College,; University of London, UK.
Distributions describing variation in the incubation and infectious periods of the human immunodeficiency virus (HIV) are derived from a series of risk or hazard functions. Four possible forms of the probability density function are considered, namely, exponential, Weibull, Erlang/gamma, and rectangular, and the prope
Wiley K; Grohar J; Niehoff School of Nursing, Loyola University of Chicago, IL; 60626.
All obstetric, gynecologic, and neonatal nurses need to protect themselves from exposure to the human immunodeficiency virus (HIV). The Centers for Disease Control s recommendations for the handling of blood and other body fluids of all patients are presented. Examples of body fluids are identified, and some suggestio
In an attempt to determine factors of predictive value in HIV (human immuno-deficiency virus) seropositive patients, particular attention was payed to symptoms indicating early involvement of the central nervous system (CNS). A cohort of healthy carriers was thus constituted. Follow-up will be carried out every six mo
J Med Ethics. 1988 Jun;14(2):87-90. Unique Identifier : AIDSLINE MED/88274911
Emson HE; University of Saskatchewan.
In its original expression as a medical value confidentiality may have been absolute; this concept has become eroded by patient consent, legal actions and change in the climate of public opinion. In particular requirements arising out of legal statutes and common law judgements have greatly modified the confidentialit
J Natl Cancer Inst. 1988 Aug 3;80(11):855-60. Unique Identifier : AIDSLINE MED/88274956
For the first time the presence of a consistent number of malignant lymphomas (95 patients with non-Hodgkin s lymphoma and 35 with Hodgkin s disease) among persons with human immunodeficiency virus infection has been documented in Europe. In contrast to American patients with malig
Nara PL; Robey WG; Pyle SW; Hatch WC; Dunlop NM; Bess JW Jr; Kelliher JC; Arthur LO; Fischinger PJ; Office of the Director, National Cancer Institute-Frederick; Cancer Research Facility, Maryland 21701.
Repeated immunizations of goats, horses, or chimpanzees with envelope glycoprotein gp120 isolated from human immunodeficiency virus type 1 (HIV-1) resulted in type-specific neutralizing-antibody responses, which began to decay approximately 20 days following the administration of antigen. This was true repeatedly for
N Engl J Med. 1988 Aug 4;319(5):274-8. Unique Identifier : AIDSLINE MED/88276060
Simonsen JN; Cameron DW; Gakinya MN; Ndinya-Achola JO; D'Costa LJ; Karasira P; Cheang M; Ronald AR; Piot P; Plummer FA; Department of Medical Microbiology, University of Nairobi, Kenya.
Heterosexual transmission of the human immunodeficiency virus (HIV) appears to occur readily in Africa but less commonly in North America and Europe. We conducted a case-control study among men attending a clinic for sexually transmitted diseases in Nairobi to determine the prevalence of HIV infection and the risk fac
Holliday RA; Cohen WA; Schinella RA; Rothstein SG; Persky MS; Jacobs JM; Som PM; Department of Radiology, New York University Medical Center, NY; 10016.
The contrast material-enhanced computed tomographic (CT) scans of 18 patients at risk for acquired immunodeficiency syndrome (AIDS) who had painless facial swelling were reviewed. All scans demonstrated parotid cysts and diffuse homogeneous cervical adenopathy. The cysts were bilateral in all but three cases. Eleven o
Am Fam Physician. 1988 Jul;38(1):117-22. Unique Identifier : AIDSLINE MED/88279311
Kaminski MA; Hartmann PM; University of Maryland School of Medicine, Baltimore.
Human immunodeficiency virus (HIV) infection affects all communities. To provide optimal patient care, physicians must understand the ramifications of HIV-antibody testing and provide appropriate counseling before and after testing. The seropositive patient requires knowledgeable surveillance. In addition, the family
Am Fam Physician. 1988 Jul;38(1):167-70. Unique Identifier : AIDSLINE MED/88279316
Greenberg MJ; State University of New York School of Medicine, Stony Brook.
Prisoners in U.S. correctional facilities constitute a unique patient population in need of health services. Physicians who provide medical services to inmates also must interact with prison officials. Drug withdrawal, self-destructive behavior and infectious diseases, including acquired immunodeficiency syndrome, are
Steeper TA; Horwitz CA; Hanson M; Henle W; Henle G; Rosenstein H; Peterson L; Amsden TW; Belzer M; Department of Laboratory Medicine, Mount Sinal Hospital,; Minneapolis, Minnesota 55404.
The authors present data from four patients with acute heterophil-negative mononucleosis-like illnesses who were initially thought to have primary Epstein-Barr virus (EBV) infections but eventually were shown to be seroconverting to the human immunodeficiency virus (HIV). Widespread lymphadenopathy and blood smears in
Huh YO; Liu FJ; Rogge K; Chakrabarty L; Lichtiger B; Section of Blood Bank, University of Texas, M. D. Anderson; Hospital and Tumor Institute, Houston 77030.
To investigate the association between the positive direct antiglobulin test (DAT) and hypergammaglobulinemia, the authors prospectively studied 154 patients, classified into three groups: Group 1, 52 patients with a positive DAT result in pretransfusion samples; Group 2, 52 patients with a negative DAT result; and Gr
Am J Epidemiol. 1988 Aug;128(2):261-7. Unique Identifier : AIDSLINE MED/88279512
Harnly ME; Swan SH; Holly EA; Kelter A; Padian N; Epidemiological Studies and Surveillance Section, California; Department of Health Services, Berkeley 94704.
Annual incidence rates for 1975-1985 were derived for Kaposi s sarcoma, non-Hodgkin s lymphomas, and seven other malignancies. Never-married men in the San Francisco Bay area constituted the study population. The pattern of increase in incidence of non-Hodgkin s lymphoma among men aged 25-44 years was similar to that
Am J Nephrol. 1988;8(2):123-6. Unique Identifier : AIDSLINE MED/88279555
Perez GO; Ortiz C; De Medina M; Schiff E; Bourgoignie JJ; Nephrology and Hepatology Sections, Veterans Administration; Medical Center, Miami, Fla.
We carried out a prospective 2-year study on the transmission of human immunodeficiency virus (HIV) infection in a chronic dialysis unit with a high prevalence (11%) of the infection. Only 1 of 45 HIV-negative patients seroconverted, and this was related to the administration of contaminated blood. We conclude that cu
Passo MS; Rosenbaum JT; Department of Ophthalmology, Veteran's Administration Hospital,; Portland, Oregon.
We diagnosed ocular syphilis in three homosexual men infected with human immunodeficiency virus (HIV). Ocular inflammation included uveitis, optic neuritis, and retinitis. Dermatologic and central nervous system manifestations of secondary syphilis were also present. The history of homosexuality was difficult to obtai
Saikevych IA; Mayer M; White RL; Ho RC; Department of Pathology, University of Hawaii, Honolulu.
We performed cytogenetic studies on direct preparations and short-term cultures from Kaposi s sarcoma cells obtained from malignant pericardial effusion. The patient, a 46-year-old man with human immunodeficiency virus infection, initially presented with metastatic Kaposi s sarcoma. Despite therapy, his tumor proved a
Aust N Z J Med. 1988 Feb;18(1):8-15. Unique Identifier : AIDSLINE MED/88280696
Tindall B; Cooper DA; Donovan B; Barnes T; Philpot CR; Gold J; Penny R; NHMRC Special Unit in AIDS Epidemiology and Clinical Research,; University of NSW.
The Sydney AIDS Project is a prospective immunoepidemiological study of 996 homosexual/bisexual men enrolled between February 1984 and January 1985. By January 1987, 32 of 386 homosexual men who were seropositive at enrollment in the study had developed AIDS, yielding a crude progression rate of between 2.8% and 4.2%
Biochem Pharmacol. 1988 Aug 1;37(15):2887-91. Unique Identifier : AIDSLINE MED/88280873
Yoshida O; Nakashima H; Yoshida T; Kaneko Y; Yamamoto I; Matsuzaki K; Uryu T; Yamamoto N; Department of Virology and Parasitology, Yamaguchi University; School of Medicine, Ube, Japan.
To determine whether donated blood samples in African countries could be pooled, then tested for the presence of human immunodeficiency virus (HIV) antibodies with a single test without loss of accuracy, a single test on five pooled samples was used, followed by individual testing of positive pools. This resulted in n
J Public Health Dent. 1988 Spring;48(2):68-73. Unique Identifier : AIDSLINE MED/88259032
Gerbert B; Badner V; Maguire B; Department of Dental Public Health and Hygiene, School of; Dentistry, University of California, San Francisco 94143.
Dental health care workers (DHCWs) can provide important diagnostic, treatment, and referral services for patients with AIDS and at risk for AIDS. They also have a responsibility to protect all patients in their practices, and themselves, from infectious disease transmission through the use of infection control. To de
This case report is about an eleven year old boy with new developed symptoms of a cellular immundeficiency and a positive HIV-serology 33 months after a CNS-leukemia relapse. After 18 weeks a progredient neurological symptomatology is beginning with motor, cognitive and behavioral disturbances and a brain atrophy in t
Pediatr Ann. 1988 May;17(5):347-51. Unique Identifier : AIDSLINE MED/88262331
Thomas P; Office of AIDS Surveillance, New York Department of Health, NY; 10013.
The vast majority of HIV infected children in the United States are from inner city families where one or both parents have used intravenous drugs. The bulk of medical opinion indicates that in most cases these children, when they appear well, should receive their routine childhood imm
FEBS Lett. 1988 Jul 4;234(1):135-40. Unique Identifier : AIDSLINE MED/88271596
Torrence PF; Kinjo J; Lesiak K; Balzarini J; De Clercq E; Section on Biomedical Chemistry, National Institute of Diabetes; and Digestive and Kidney Diseases, Bethesda, MD 20892.
In an attempt to provide a derivative of 3 -azido-3 -deoxythymidine ( AZT ) which might be sequestered in the central nervous system and release AZT, the dihydropyridine ester 5 -(1,4-dihydro-1-methyl-3-pyridinylcarbonyl)-3 -deoxythymidine, was synthesi
Klin Wochenschr. 1988 May 2;66(9):410-1. Unique Identifier : AIDSLINE MED/88275291
von Hintzenstern J; Jahn G; Mang K; Harms D; Fleckenstein B; Klinische und Molekulare Virologie, Universitat; Erlangen-Nurnberg.
In a 14-year-old boy with severe hemophilia B, HIV seroconversion was observed about 2 years after substitution therapy had been changed to heat-treated PPSB concentrates. This shows that HIV-antibodies may appear in hemophiliacs after time periods longer than generally assumed.
Farrell PL; Heinemann MH; Roberts CW; Polsky B; Gold JW; Mamelok A; Department of Ophthalmology, New York Hospital Cornell Medical; Center, NY 10021.
A patient with human immunodeficiency virus (HIV) type 1 infection developed chronic iridocyclitis and anterior vitritis that were poorly responsive to topical and systemic corticosteroid therapy. Anterior chamber paracentesis was performed and HIV was isolated from culture of aqueous humor. Subsequent treatment with
Mizuma H; Litwin S; Zolla-Pazner S; Laboratory Service, New York Veterans Administration Medical; Center, New York 10010.
Peripheral blood mononuclear cells from HIV-infected individuals spontaneously secrete elevated levels of IgG, IgM and IgD. This increased level of synthesis and secretion is similar in HIV-infected subjects with no or few symptoms, in ARC patients and in AIDS patients. Thus, abnormal B-cell activation is characterist
Stokes DC; Shenep JL; Horowitz ME; Hughes WT; Department of Infectious Diseases, St. Jude Children's Research; Hospital, Memphis.
Pneumocystis carinii pneumonia (PCP) presented as unilateral hyperlucent lung in a 27-month-old patient with a brain tumor who was receiving chemotherapy. Although unilateral pneumonia is an uncommon presentation of PCP in non-AIDS patients, PCP must be suspected in any pediatric cancer patient not receiving trimethop
Int J Epidemiol. 1988 Mar;17(1):162-7. Unique Identifier : AIDSLINE MED/88256436
Franceschi S; Tirelli U; Vaccher E; Serraino D; Crovatto M; De Paoli P; Diodato S; La Vecchia C; Decarli A; Monfardini S; Regional Center for Oncological Referral, Aviano, Italy.
Prevalence and determinants of HIV infection were assessed in 313 parenteral drug addicts admitted to five Centers for Drug-Addict Assistance and two prisons located in the northeast of Italy (Friuli Venezia-Giulia), an area some distance from the major Italian cities first reached
Lonberg N; Gettner SN; Lacy E; Littman DR; DeWitt Wallace Research Laboratory, Memorial Sloan-Kettering; Cancer Center, New York, New York 10021.
The T-cell surface glycoprotein CD4 is thought to function as a receptor for class II major histocompatibility complex molecules. Human CD4 is also the lymphoid cell receptor for human immunodeficiency virus, the causative agent of acquired immune deficiency syndrome. The observed infection of the central nervous syst
Reimer CB; Black CM; Holman RC; Wells TW; Ramirez RM; Sa-Ferreira JA; Nicholson JK; McDougal JS; Division of Host Factors, Centers for Disease Control, Atlanta.
The serum concentrations of 11 Ig isotypes (IgG, IgG1, IgG2, IgG3, IgG4, IgA, IgA1, IgA2, IgM, IgD, and IgE) were measured in four relatively small groups of homosexual (or bisexual) males. All these patients were seropositive for HIV. Two of the groups (nonprogressors) were clinically stable for approximately 2 years
Landau NR; Warton M; Littman DR; Department of Microbiology and Immunology, University of; California, San Francisco 94143.
CD4, a cell-surface glycoprotein expressed on a subset of T-cells and macrophages, serves as the receptor for the human immunodeficiency virus (HIV) (reviewed in ref. 1), binding to the HIV envelope glycoprotein, gp120 with high affinity. Attempts to block infection in vivo by raising antibodies against gp120 have fai
Bedinger P; Moriarty A; von Borstel RC 2d; Donovan NJ; Steimer KS; Littman DR; Department of Microbiology and Immunology, University of; California, San Francisco 94143.
Binding of the human immunodeficiency virus (HIV) to infectable host cells, such as B and T lymphocytes, monocytes and colorectal cells, is mediated by a high-affinity interaction between the gp120 component of the viral envelope glycoprotein and the CD4 receptor. Upon binding, it is thought that the second component
Shaw JP; Utz PJ; Durand DB; Toole JJ; Emmel EA; Crabtree GR; Howard Hughes Medical Institute, Stanford University, CA 94305.
Molecules involved in the antigen receptor-dependent regulation of early T cell activation genes were investigated with the use of functional sequences of the T cell activation-specific enhancer of interleukin-2 ( IL-2 ). One of these sequences forms a protein complex, N
Am J Med. 1988 Jul;85(1):59-64. Unique Identifier : AIDSLINE MED/88267255
Berman A; Espinoza LR; Diaz JD; Aguilar JL; Rolando T; Vasey FB; Germain BF; Lockey RF; Department of Internal Medicine, University of South Florida; College of Medicine, Tampa 33612.
PURPOSE: The prevalence and characteristics of the rheumatic and extra-rheumatic manifestations of human immunodeficiency virus (HIV) infection were determined in a prospective manner. PATIENTS AND METHODS: One hundred one patients with HIV infection were consecutively interviewed and examined. The prevalence of autoa
Weinke T; Sixt C; de Matos-Marques B; Ruf B; Pohle HD; II. Medizinische Klinik, Freien Universitat Berlin.
Forty-nine episodes of Pneumocystis carinii pneumonia, treated with trimethoprim-sulfamethoxazole among 46 patients with AIDS were analysed retrospectively for any side effects. For only two were there insufficient data. There were 39 toxic reactions, 15 of them serious: leukopenia (n = 23), abnormal liver functions (
Roy S; Fitz-Gibbon L; Poulin L; Wainberg MA; Lady Davis Institute for Medical Research, Sir Mortimer B. Davis; Jewish General Hospital, Montreal, Quebec, Canada.
We have infected peripheral blood-derived monocyte/macrophage cultures with HIV-1 in order to determine the effect of such infection on cellular immunoregulatory function. We have confirmed that monocytes/macrophages are susceptible to infection by HIV-1, as determined by in situ hybridization using a HIV-1-specific R
Schrier RD; Gnann JW Jr; Langlois AJ; Shriver K; Nelson JA; Oldstone MB; Department of Immunology, Research Institute of Scripps Clinic,; La Jolla, California 92037.
Using synthetic peptides, we characterized the B-lymphocyte (antibody) and T-lymphocyte (proliferation) responses to an immunodominant epitope of human immunodeficiency virus type 1 (HIV-1) located near the amino-terminal end of the transmembrane glycoprotein (env amino acids 598 to 609). Both immunoglobulin M (IgM) a
Orenstein JM; Meltzer MS; Phipps T; Gendelman HE; Department of Pathology, George Washington University Medical; Center, Washington, D.C. 20036.
Recombinant human colony-stimulating factor-1-treated human peripheral blood-derived monocytes-macrophages are efficient host cells for recovery of the human immunodeficiency virus (HIV) from blood leukocytes of patients with acquired immunodeficiency syndrome. These cells can be maintained as viable monolayers for in
Trimethoprim-sulfamethoxazole (TMS) desensitization was carried out in three patients with AIDS and Pneumocystis carinii pneumonia (PCP) in whom treatment with TMS had to be discontinued after 8 to 12 days due to an allergic reaction. Although the pneumonia was under control we decided for a desensitization to TMS bec
N Z Med J. 1988 Jul 27;101(850):471-5. Unique Identifier : AIDSLINE MED/88276376
Carter JM; Town GI; Fisher M; Holloway L; Jones MR; McSweeney P; Department of Medicine, Wellington School of Medicine.
From 1982 to 1987, 22 patients with proven Pneumocystis carinii pneumonia were diagnosed at Wellington Hospital. Patients comprised 15 males and 7 females aged 15-76 years and included seven with AIDS, eight with haematological malignancy and seven with renal disease. Two distinct clinical prodromes occurred. In renal
Nemir RL; Krasinski K; Department of Pediatrics, New York University Medical Center,; Bellevue Hospital Center, New York 10016.
Tuberculosis (TBC) continues to be a major health problem. Between January 1, 1980, and April 30, 1986, 211 children and adolescents presented with a positive tuberculin reaction or symptoms suggestive of tuberculosis. Active disease occurred in 35 (17%); 29 of these had primary infection, whereas 4 adolescents presen
Kamani N; Lightman H; Leiderman I; Krilov LR; Department of Pediatrics, Schneider Children's Hospital of Long; Island Jewish Medical Center, New Hyde Park, New York.
The long term clinical outcome for infants and children with the pediatric acquired immunodeficiency syndrome-related complex is unknown. This report describes our experience with 14 patients with acquired immunodeficiency syndrome-related complex who have been followed for 11 to 71 months since the onset of their sym
Post MJ; Tate LG; Quencer RM; Hensley GT; Berger JR; Sheremata WA; Maul G; Department of Radiology, University of Miami School of Medicine,; FL 33101.
The value and limitations of CT and MR in human immunodeficiency virus (HIV) infection of the brain was determined by a retrospective analysis of the CT scans (22) and MR images (7) in 22 patients with pathologically proved HIV encephalitis (21) or meningitis (1). Our clinical-radiologic-pathologic correlation suggest
Am J Epidemiol. 1988 Aug;128(2):254-60. Unique Identifier : AIDSLINE MED/88279511
Romano N; De Crescenzo L; Lupo G; Torregrossa MV; Russo Alesi D; Portera M; Vitale F; Istituto d'Igiene G. D'Alessandro Universita degli Studi di; Palermo-Policlinico, Italy.
A cross-sectional seroepidemiologic study was carried out on household contacts and sexual partners of human immunodeficiency virus (HIV) antibody-positive intravenous drug abusers in Palermo, Italy , in 1985 to evaluate factors that influenced HIV transmission. A total of 43 index c
Ann Intern Med. 1988 Aug 15;109(4):280-7. Unique Identifier : AIDSLINE MED/88280037
Sattler FR; Cowan R; Nielsen DM; Ruskin J; Kaiser Permanente Medical Center, Los Angeles, California.
STUDY OBJECTIVE: To ascertain the efficacy and toxicity of trimethoprim-sulfamethoxazole or pentamidine when either is given alone during the entire treatment period for Pneumocystis carinii pneumonia in patients with the acquired immunodeficiency syndrome (AIDS). DESIGN: Prospective, randomized, noncrossover comparis
Straka BF; Whitaker DL; Morrison SH; Oleske JM; Grant-Kels JM; Hartford Hospital, Department of Medicine, CT.
The acquired immunodeficiency syndrome (AIDS) in children is now known to be a clinical entity separate and distinct from AIDS in adults. In this article we present a review of the recent literature describing the history, definitions, epidemiology, differential diagnosis, and immunologic and clinical features of pedi
Resler SS; Department of Dietetics, Massachusetts General Hospital, Boston.
Often the complications of the acquired immunodeficiency syndrome (AIDS) have a negative impact on nutritional status. Weight loss and protein depletion are commonly seen among the AIDS population. Though the relationship between disease progression and nutritional status has not been established, maintaining good nut
Wick G; Hengster P; Bock G; Dierich MP; Institute for General and Experimental Pathology, University of; Innsbruck, Medical School, Austria.
One of the most commonly used methods for demonstration of HIV antibodies is indirect immunofluorescence employing HIV-infected, CD4-positive lymphoid cell lines as antigenic substrate. Immunofluorescence with conventional optic equipment is reported to be slightly less sensitive than enzyme-linked immunoassay (ELISA)
Runnells RR; Department of Dental Education, University of Utah, School of; Pathology, Salt Lake City.
Although it is not possible to cover all of the ramifications of infection control in prosthodontics, currently available information may be summarized as follows: 1. All dental disciplines must be concerned with the dangers involved in the spread of certain infectious diseases. 2. Prosthodontists and their ancillary
Quinn TC; Riggin CH; Kline RL; Francis H; Mulanga K; Sension MG; Fauci AS; Laboratory of Immunoregulation, National Institute of Allergy and; Infectious Diseases, Bethesda, Md.
Unscreened blood transfusions continue to be one of the major modes of transmission of the human immunodeficiency virus (HIV) in developing countries, such as in Central Africa, where 5% to 18% of blood donors are HIV seropositive. We evaluated a rapid latex agglutination assay using a novel recombinant envelope polyp
Dormont D; Boussin F; Merrouche Y; Division de Radiobiologie et Radioprotection, Centre de; Recherches du Service de Sante des Armees, Clamart, France.
Disorders of the nervous system frequently complicate Acquired Immune Deficiency Syndrome (AIDS). They may be related to the development of opportunistic agents (toxoplasmosis, cryptococcossis, cytomegalovirus , JC Virus), or primary CNS lymphoma
Proc Natl Acad Sci U S A. 1988 Jul;85(13):4686-90. Unique Identifier : AIDSLINE MED/88263013
Kohl NE; Emini EA; Schleif WA; Davis LJ; Heimbach JC; Dixon RA; Scolnick EM; Sigal IS; Department of Molecular Biology, Merck Sharp & Dohme Research; Laboratories, West Point, PA 19486.
Retroviral proteins are synthesized as polyprotein precursors that undergo proteolytic cleavages to yield the mature viral proteins. The role of the human immunodeficiency virus (HIV) protease in the viral replication cycle was examined by use of a site-directed mutation in the protease gene. The HIV protease gene pro
Stat Med. 1988 May;7(5):549-57. Unique Identifier : AIDSLINE MED/88263778
Lachenbruch PA; Division of Biostatistics, UCLA School of Public Health 90024.
This paper examines the effects on sensitivity and specificity of various multiple reading procedures. Multiple reading procedures entail the performance of a diagnostic test several times and consequent assignment of the subject to an affected or unaffected group. A Unanimity rule (that is, all tests must be posi
Z Hautkr. 1988 Apr 15;63(4):336-7. Unique Identifier : AIDSLINE MED/88266153
Gallenkemper G; Kuhlwein A; Facharztliche Untersuchungsstelle f. Haut-; Geschlechtskrankheiten des Bundeswehrkrankenhauses Hamburg.
In a retrospective study on 21 HIV-positive patients (aged between 18 and 28) in stage WR 1 CDC II and WR 2 CDC III, we looked for yeast in tongue swabs and stool samples. About 2/3 of the cultures of stage WR 1 CDC II and nearly all cultures of stage WR CDC III revealed infection with yeasts.
Hilleman MR; Merck Institute for Therapeutic Research, Merck Sharp & Dohme; Research Laboratories, West Point, Pennsylvania 19486.
Human hepatitis B virus and human immunodeficiency virus (HIV), that causes AIDS, share attributes and possible evolutionary relationships. The specific requirements for inducing effective immunity against hepatitis B and HIV are discussed. Lessons learned in studies of hepatitis B and its vaccine may find application
Ada GL; Department of Microbiology, John Curtin School of Medical; Research, Australian National University, Canberra.
Vaccines have been used almost exclusively to prevent or control infectious diseases with the aim of long-lasting immunity. Some, composed of attenuated viruses, have been highly successful and this may be due to the generation of high levels of B memory cells and their steady recruitment to form antibody secreting ce
Fagnart OC; Sindic CJ; Laterre C; Laboratory of Neurochemistry, Catholic University of Louvain,; Brussels, Belgium.
S100 protein (S100) was assayed by particle counting immunoassay in serum samples from 50 healthy individuals, 325 patients with various neurological disorders, and 20 patients with malignant melanoma. The detection limit for this protein was 0.3 microgram/L. We detected none in healthy individuals or in 50 patients w
Brown LK; Fritz GK; Department of Child and Family Psychiatry, Rhode Island Hospital,; Providence 02903.
As plans for massive public AIDS education grow, pediatricians will become increasingly involved with school systems as consultants and leaders. A review of relevant literature on students current level of knowledge about AIDS and on educational efforts to date with high-risk groups (homosexuals and intravenous drug
Roberts MW; Brahim JS; Rinne NF; National Institute of Dental Research, Bethesda, MD 20892.
Early diagnosis of AIDS is vital in providing appropriate referral for medical care and counseling. Subtle intraoral signs and symptoms identified by the dental practitioner can aid in the diagnosis of the disease. Because the role of the practitioner in detection and treatment of AIDS patients is becoming greater, si
Hollister LE; University of Texas Medical School, Houston.
Despite the fairly large literature that developed during the past 15 years or so, the effect of cannabinoids on the immune system is still unsettled. The evidence has been contradictory and is more supportive of some degree of immunosuppression only when one considers in vitro studies. These have been seriously flawe
Henderson LE; Benveniste RE; Sowder R; Copeland TD; Schultz AM; Oroszlan S; Laboratory of Molecular Virology and Carcinogenesis, Bionetics; Research, Inc., NCI-Frederick Cancer Research Facility, Maryland; 21701.
A simian immunodeficiency virus (SIV) designated SIVMne was isolated from a pig-tailed macaque with lymphoma housed at the University of Washington Regional Primate Research Center, Seattle. To better establish the relationship of SIVMne to other immunodeficiency viruses, we purified and determined the partial amino a
Lillehoj EP; Salazar FH; Mervis RJ; Raum MG; Chan HW; Ahmad N; Venkatesan S; Laboratory of Molecular Microbiology, Program Resources, Inc.,; Frederick Cancer Research Facility, Maryland 21701.
We have purified a 10,774-dalton protein from human immunodeficiency virus (HIV) type 1 that is encoded in the protease domain of the pol open reading frame (ORF). Radiochemical amino acid microsequencing identified 12 amino acids from the stretch of 39 N-terminal residues of this protein, beginning with a PQITLW sequ
Koff WC; Hoth DF; Vaccine Research and Development Branch, AIDS Program, National; Institute of Allergy and Infectious Diseases, Bethesda, MD 20892.
Recent advances in delineating the molecular biology of human immunodeficiency virus type 1 (HIV-1) have led to innovative approaches to development of a vaccine for acquired immunodeficiency syndrome (AIDS). However, the lack of understanding of mechanisms of protective immunity against HIV-1, the magnitude of geneti
Shulman LC; Mantell JE; St Luke's-Roosevelt Hospital Center, New York, NY 10019.
The unanticipated onset of Acquired Immunodeficiency Syndrome in the United States , followed by its gradual progression into a full-blown, uncontrollable epidemic, has had severe economic and organizational consequences for the American health care system. AIDS has taken its toll on th
Am J Gastroenterol. 1988 Aug;83(8):882-4. Unique Identifier : AIDSLINE MED/88279504
Reddy KR; Chan JC; Smiley D; Jeffers LJ; Schiff ER; Department of Medicine, Veterans Administration Medical Center,; University of Miami School of Medicine, Florida.
Salmonella represents an infrequent cause of spontaneous bacterial peritonitis in cirrhotic ascites. A cirrhotic patient, an alcoholic and former intravenous drug abuser, developed spontaneous group B Salmonella enteritidis (undetermined serotype) bacterial peritonitis. The isolation of this pathogen, a common cause o
Ann Med Interne (Paris). 1988;139(2):80-3. Unique Identifier : AIDSLINE MED/88280107
Lange JM; Goudsmit J; De Wolf F; Coutinho RA; van der Noordaa J; Department of Virology, University of Amsterdam, Netherlands.
HIV antigenaemia can be detected at or possibly before the onset of clinical symptoms of primary HIV infection. Approximately one week after the onset of HIV antigenaemia, a primary anti-HIV IgM response may occur. A week later, generally within 3 to 6 weeks after infection, anti-HIV IgG can be detected. After primary
Ann Med Interne (Paris). 1988;139(2):84-6. Unique Identifier : AIDSLINE MED/88280108
De Clercq E; Rega Institute for Medical Research, Katholieke Universiteit; Leuven, Belgium.
Antiviral chemotherapy has come of age. Several compounds, i.e. amantadine, rimantadine, idoxuridine, trifluridine, vidarabine, acyclovir , ribavirin and azidothymidine, have been licensed for clinical use and other promising compounds may follow soon. The search for new antivira
Albert J; Pehrson PO; Schulman S; Hakansson C; Lovhagen GB; Berglund O; Beckman S; Fenyo EM; Department of Virology, National Bacteriological Laboratory,; Stockholm, Sweden.
We have examined 39 couples, each consisting of one HIV-seropositive index case and one seronegative sexual partner. HIV isolations, HIV antigen (HIV-Ag) tests and HIV antibody tests were performed on samples from these 78 individuals. Results were compared with those of 68 unselected individuals. Neither HIV, nor HIV
Narvanen A; Korkolainen M; Kontio S; Suni J; Turtianen S; Partanen P; Soos J; Vaheri A; Huhtala ML; Labsystems Research Laboratories, Helsinki, Finland.
A synthetic pentadecapeptide (A15; env residues 599-613: SGKLICTTAVPWNAS), derived from a hydrophobic region in the transmembrane protein gp41 of HIV-1 and comprising a highly immunoreactive antigenic site in eliciting antibody responses during HIV-1 infection in humans, was used to purify, by affinity, the correspond
Colebunders R; Greenberg AE; Francis H; Kabote N; Izaley L; Nguyen-Dinh P; Quinn TC; Van der Groen G; Curran JW; Piot P; Project SIDA, Department of Public Health, Kinshasa, Zaire.
Three children are described in whom pre-transfusion samples were HIV-seronegative and post-transfusional samples, obtained within 1 week after transfusion, were HIV-seropositive. Two of them developed a transient fever within 1 week of receiving the blood transfusion, and a transient generalized skin eruption which l
Fultz PN; Switzer WM; Schable CA; Desrosiers RC; Silva DP; McCormick JB; AIDS Program, Center for Infectious Diseases, Atlanta, Georgia; 30322.
To determine the past prevalence of HIV-1 and HIV-2 in West Africa, we tested 440 serum samples collected in 1980 from people living in rural areas of Guinea Bissau. The sera were screened for antibodies by enzyme immunoassay (EIA) using purified simian immunodeficiency virus (SIV)
Tross S; Price RW; Navia B; Thaler HT; Gold J; Hirsch DA; Sidtis JJ; Department of Neurology, Memorial Sloan-Kettering Cancer Center,; New York 10021.
The AIDS dementia complex (ADC) is a frequent complication of advanced HIV infection. In order to better define the neuropsychological character and progression of the ADC, four groups of subjects were studied with a battery of neuropsychological tests: an HIV-seronegative comparis
Sonnerborg AB; Ehrnst AC; Bergdahl SK; Pehrson PO; Skoldenberg BR; Strannegard OO; Department of Virology, Stockholm County Council, Sweden.
Human immunodeficiency virus (HIV) could be isolated from the cerebrospinal fluid (CSF) of the majority (62%) of 72 patients in various stages of HIV infection. This high rate of successful virus isolation was achieved only when the time from lumbar puncture to initiation of the cell cultures was short, i.e. not excee
Weiss RA; Clapham PR; Weber JN; Whitby D; Tedder RS; O'Connor T; Chamaret S; Montagnier L; Chester Beatty Laboratories, Institute of Cancer Research,; London, UK.
The neutralization properties of three independent HIV-2 isolates were examined in comparison with four diverse HIV-1 strains. Human sera containing antibodies specific to HIV-2 can cross-neutralize HIV-1. By contrast, HIV-1 sera are group-specific and have no neutralizing effect on HIV-2. Therefore, HIV-2 antigens ma
Matthey F; Dept of Haematology, Middlesex Hospital, London.
Awareness of the potential benefits of autologous blood transfusion (ABT) has recently increased since the advent of AIDS. The risk of transmission of this and other diseases by blood transfusion in the UK is very small. Nevertheless, ABT can play a useful complementary role to the homologous blood supply.
Br Med J (Clin Res Ed). 1988 May 7;296(6632):1289-92. Unique Identifier : AIDSLINE MED/88252694
McCormick A; Medical Statistics Division, Office of Population Censuses and; Surveys, London.
Death certification should be able to provide accurate data on the number of deaths due to AIDS as a basis for predicting future deaths from the syndrome. Trends in deaths from other causes may identify conditions that have not been recognised to be associated with HIV infection. Mortality statistics with reference to
Schlech WF 3d; Department of Medicine, Dalhousie University, Halifax, Nova; Scotia.
Infectious hazards to anaesthesia personnel are real but the appropriate use of immunization, universal blood and body fluid precautions, and respiratory precautions where appropriate, should minimize the risk of infection at work. In particular, the resistance of physicians to immunization, especially to hepatitis B,
Pediatr Ann. 1988 May;17(5):332-9. Unique Identifier : AIDSLINE MED/88262329
Oleske JM; Connor EM; Grebenau MD; Minnefor AB; Division of Pediatric Allergy, Immunology and Infectious; Diseases, University of Medicine and Dentistry, New Jersey; Medical School, Newark 07103.
Proc Natl Acad Sci U S A. 1988 Jul;85(13):4625-7. Unique Identifier : AIDSLINE MED/88263000
Rossmann MG; Department of Biological Sciences, Purdue University, West; Lafayette, IN 47907.
The tertiary structure of most icosahedral viral capsid proteins consists of an eight-stranded antiparallel beta-barrel with a hydrophobic interior. In a group of picornaviruses, this hydrophobic pocket can be filled by suitable organic molecules, which thereby stop viral uncoating after attachment and penetration int
Proc Natl Acad Sci U S A. 1988 Jul;85(13):4700-4. Unique Identifier : AIDSLINE MED/88263016
Kawakami K; Scheidereit C; Roeder RG; Laboratory of Biochemistry and Molecular Biology, Rockefeller; University, New York, NY 10021.
The enhancer-binding factor NF-kappa B, which is found only in cells that transcribe immunoglobulin light chain genes, has been purified from nuclear extracts of Namalwa cells (human Burkitt lymphoma cells) by sequence-specific DNA affinity chromatography. The purified NF-kappa B has been identified as a 51-kDa polype
Cuthbert RJ; Ludlam CA; Brookes E; McClelland DB; Department of Haematology, Royal Infirmary of Edinburgh, UK.
Two batches of heat-treated factor VIII concentrate were found to contain anti-HIV-positive plasma donations. The batches were dry-heat-treated at 68 degrees C for 2 and 24 h, respectively. No HIV seroconversions occurred in 13 susceptible haemophiliacs receiving a total of 540 bottles of these factor VIII preparation
Am J Public Health. 1988 Aug;78(8):949-52. Unique Identifier : AIDSLINE MED/88267350
Lafferty WE; Hopkins SG; Honey J; Harwell JD; Shoemaker PC; Kobayashi JM; Seattle-King County Department of Public Health, AIDS; Surveillance Unit, WA 98101.
We analyzed Washington State inpatient hospital utilization for 165 AIDS (acquired immunodeficiency syndrome) cases with 344 hospitalizations from July 1984 through December 1985. We found that mean charges per hospitalization were $9,166 and mean length of stay was 13.3 days. In addition, evaluation of two diagnosis-
Ann Allergy. 1988 Jul;61(1):30-4. Unique Identifier : AIDSLINE MED/88267574
Bloom RD; Triglia D; Asser S; Department of Pediatrics, University of California, San Diego, La; Jolla.
Until recently, donors of serum for intravenous immunoglobulin (IVIG) were not screened for the presence of antibodies to the human immunodeficiency virus (HIV). We detected anti-HIV antibodies (Ab) in the sera of seven patients following IVIG infusions. In addition, enzyme immunoassay values increased and/or Western
Re MC; Furlini G; Baldassarri B; Chiodo F; Institute of Microbiology, Policlinico S. Orsola, Bologna, Italy.
Twelve homosexual males who seroconverted to human immunodeficiency virus (HIV) were followed-up for over two years. Analysis of sera by immunoblotting showed that seroconversion was characterized by the presence of specific IgM that reacted mainly with viral polypeptides of molecular weights ranging from 17 Kd to 55
Schaad UB; Gianella-Borradori A; Perret B; Imbach P; Morell A; Department of Paediatrics, University of Berne, Inselspital,; Switzerland.
Seven paediatric patients with symptomatic human immunodeficiency virus (HIV) infection were prospectively studied for 6-24 months after the start of intravenous immune globulin (IVIG) therapy. There was substantial clinical benefit during IVIG treatment with marked reduction of febrile and infectious episodes, normal
Abdelaziz AA; el-Nakeeb MA; Faculty of Pharmacy, Tanta University, Egypt.
The sporicidal activity of 1% solutions of five local anaesthetics and five preservatives (cetrimide, chlorocresol, chlorhexidine, phenoxyethanol and phenylmercuric nitrate) at their pharmacopeial concentrations, alone and in binary combinations was determined against Bacillus subtilis and Aspergillus niger spores at
Gundlach DC; Central Ohio Medical Group, Columbus 43215.
Recent medical literature has voiced growing concern over the potential spread of human immunodeficiency virus and hepatitis B among health care workers. In response to this concern, the Central Ohio Medical Group developed an infection control policy involving employee immunizations, needle stick protection protocols
Winkelstein A; Kingsley LA; Klein RS; Lyter DW; Evans TL; Rinaldo CR Jr; Weaver LD; Machen LL; Schadle RC; Department of Medicine, Montefiore Hospital, Pittsburgh, PA; 15213.
The T-cell colony assay is a highly sensitive measure of immunological dysfunction. The present study evaluated this in vitro response in asymptomatic HIV-infected homosexuals, those with chronic adenopathy as their only clinical manifestation and patients with either ARC or AIDS. The mean colony count in antibody-pos
Eales LJ; Farrant J; Helbert M; Pinching AJ; Department of Immunology, St Mary's Hospital Medical School,; London, UK.
The antigen-specific immune response in HIV sero-positive individuals is depressed or absent. This may be due in part to abnormal co-operation between T lymphocytes and antigen presenting cells (APC). We have isolated from the peripheral blood of healthy heterosexuals and patients with persistent generalized lymphaden
Brockmeyer NH; Kreuzfelder E; Mertins L; Chalabi N; Kirch W; Scheiermann N; Goos M; Ohnhaus EE; Department of Dermatology, University of Essen, Federal Republic; of Germany.
The immunomodulatory potency of cimetidine, a histamine H2 receptor antagonist, was investigated in 33 AIDS-related complex (ARC) patients performing detailed immunological and clinical evaluations. Cimetidine was administered orally in daily doses of 1200 mg for a period of 5 months with an interruption of therapy af
Barnaba V; Valesini G; Gattamelata G; Benvenuto R; Velardi A; Balsano F; Istituto I Clinica Medica, Universita di Roma La Sapienza,; Italy.
CD4 cells forming conjugates with natural killer target cells (K562 cells) were measured in the peripheral blood of anti-HIV antibody positive AIDS related complex (ARC) patients and in three control groups (asymptomatic individuals at risk, normal healthy people and patients with acute hepatitis B). These CD4 cells,
Myskowski PL; Niedzwiecki D; Shurgot BA; Kaufman D; Krown SE; Nisce L; Safai B; Department of Medicine, Memorial Sloan-Kettering Cancer Center,; New York, NY 10021.
The records of 187 consecutive patients with acquired immunodeficiency syndrome (AIDS)-associated Kaposi s sarcoma were analyzed retrospectively for a number of prognostic variables. In a multivariate analysis, the initial site of disease was found to be related to survival. Initial lesions on the skin of the lower ex
The number of C3b receptors (CR1) on erythrocytes (E) was measured, using a newly developed flow cytometry assay and a standard radioimmunoassay, in HIV-infected individuals and in a normal control population. The number of CR1/E was significantly decreased in symptomatic HIV-infected patients with ARC and acquired im
De Truchis P; Cadranel J; Touboul JL; Denis M; Fouret P; Roux P; Mayaud C; Akoun G; Service de Pneumologie et de Reanimation respiratoire, Hopital; Tenon, Paris.
Seventy out of 125 patients with HIV infection had diffuse alveolo-interstitial pneumonia usually caused by an opportunistic infection, notably pneumocystosis. Nineteen patients had only localized lung opacities due either to usual or tuberculous bacterial infections or to Kaposi s sarcoma. In 10 patients with pleural
Namiki TS; Nichols P; Young T; Martin SE; Chandrasoma P; Department of Pathology, LA County-USC Medical Center 90033.
Twelve cases of central nervous system lymphoma diagnosed by stereotaxic brain biopsy are reviewed to determine the most effective method to establish the diagnosis given the small amount of tissue obtained by this technique. The stereotaxic biopsy material was examined cytologically, histologically, and immunocytoche
Montefiori DC; Robinson WE Jr; Mitchell WM; Department of Pathology, Vanderbilt University, School of; Medicine, Nashville, Tennessee 37232.
Mismatched double-stranded RNA of the form r(I)n.r(C12-U)n (Ampligen) has been shown to be active against human immunodeficiency virus type 1 (HIV-1) using CEM and C3 cells as targets for infection by the highly similar HIV-1 isolates HTLV-IIIB and LAV (Montefiori, D.C. and Mitchell, W.M., 1987, Proc. Natl. Acad. Sci.
Calcaterra NB; Vicario LR; Roveri OA; Centro de Estudios Fotosinteticos y Bioquimicos, Facultad de; Ciencias Bioquimicas y Farmaceuticas, Rosario, Argentina.
Suramin, a drug intensively used in the chemotherapy of African trypanosomiasis and onchocerciasis, is currently being tested in clinical trials for AIDS treatment. Its effects on mitochondrial energy metabolism in mammals were studied. At low concentrations it inhibited ATP synthesis and ATPase activity in submitocho
Prince HE; Czaplicki CD; Cellular Immunology Laboratory, American Red Cross Blood; Services, Los Angeles, California 90006.
Mononuclear cells (MC) from many individuals exposed to human immunodeficiency virus (HIV) exhibit a reduced proliferative response to a suboptimal concentration of phytohemagglutinin (PHA). However, the relative contributions of the 2 major T-cell subsets, namely CD4 and CD8 lymphocytes, to this reduced response rema
Sjovall J; Karlsson A; Ogenstad S; Sandstrom E; Saarimaki M; Department of Clinical Pharmacology, Astra Alab AB, Sodertalje,; Sweden.
Six patients with human immunodeficiency virus were given foscarnet in oral solution, 4000 mg every 6 hours for 3 days, followed by a washout period for 2 days and continuous intravenous infusion of 16,000 mg/24 hr over 72 hours. After oral foscarnet, plasma concentrations were less than 33 mumol/L in four patients; t
Watanabe H; Matsushita S; Kamikawaji N; Hirayama K; Okumura M; Sasazuki T; Department of Internal Medicine, School of Medicine, Fukuoka; University, Japan.
The development of antiviral vaccines has been accelerated using monoclonal antibody and/or recombinant DNA techniques, the objective being to prevent grave viral infectious diseases, such as acquired immunodeficiency syndrome (AIDS), adult T-cell leukemia (ATL), and hepatitis B virus (HBV)-associated liver diseases.
Gerbert B; Maguire B; Badner V; Greenspan D; Greenspan J; Barnes D; Carlton R; Department of Dental Public Health and Hygiene, School of; Dentistry, University of California, San Francisco 94143-0754.
The efficacy of an educational intervention designed to improve dentists knowledge, attitudes, and behaviors about acquired immune deficiency syndrome (AIDS) was tested. The intervention had three components: computerized feedback comparing participants own knowledge, attitudes, and behaviors with those of fellow pa
Reitz MS Jr; Wilson C; Naugle C; Gallo RC; Robert-Guroff M; Laboratory of Tumor Cell Biology, National Cancer Institute,; Bethesda, Maryland 20892.
Transmission and growth of HIV-1 produced from the biologically active clone HTLV-III/HXB2D in the constant presence of a neutralizing antiserum yielded a viral population specifically resistant to neutralization by the same antiserum. Molecular clones MX-1 and -2, containing the entire envelope gene, were obtained fr
FEBS Lett. 1988 Jun 20;233(2):393-6. Unique Identifier : AIDSLINE MED/88255336
McPhee DA; Kemp BE; Cumming S; Stapleton D; Gust ID; Doherty RR; NHMRC Special Unit for AIDS Virology, Macfarlane Burnet Centre; for Medical Research, Fairfield Hospital, Victoria, Australia.
A series of synthetic peptides corresponding to segments of HIV encoded proteins were selected using criteria described by Welling et al. [(1985) FEBS Lett. 188, 215]. Synthetic peptide analogs to gp120 (2-13), (55-65), gp41 (582-596) (659-670) and tatIII (71-83) were recognized by 41-67% of sera or plasma from indivi
Denis F; Leonard G; Sangare A; Gershy-Damet G; Rey JL; Soro B; Schmidt D; Mounier M; Verdier M; Baillou A; et al; Department of Bacteriology and Virology, Centre Hospitalier; Regional, Limoges, France.
The efficacies of nine enzyme-linked immunosorbent assays (EIA) for antibody to human immunodeficiency virus type 1 (HIV-1) and one EIA for antibody to HIV-2 in detecting antibody to HIV-2 were studied. The competitive EIAs for antibody to HIV-1 were less sensitive than the indirect EIAs. The overall prevalence of pos
White PM; Virus Reference Laboratory, Central Public Health Laboratory,; Colindale, London.
Indirect immunofluorescence, competitive radioimmunoassay, HTLV I-enzyme linked immunosorbent assay and gelatin particle agglutination Serodia-ATLA were compared in terms of their ability to detect antibody to human T cell leukaemia virus I (HTLV I). The sensitivities were 96.9%, 92%, 97.0%, and 100%, respectively, an
Rowe M; Finke J; Szigeti R; Klein G; Department of Tumor Biology, Karolinska Institute, Stockholm,; Sweden.
A total of 116 sera from healthy individuals and from patients with Burkitt s lymphoma (BL), nasopharyngeal carcinoma (NPC) or rheumatoid arthritis (RA) were studied with respect to antibody responses to each of the seven known transformation-associated Epstein-Barr virus (EBV)-encoded antigens [latent membrane protei
Nimer SD; Morita EA; Martis MJ; Wachsman W; Gasson JC; Division of Hematology-Oncology, UCLA School of Medicine 90024.
T-cell activation induces expression of the hematopoietic growth factor granulocyte-macrophage colony-stimulating factor (GM-CSF). To define the molecular events involved in the induction of GM-CSF gene expression more clearly, we prepared and analyzed deletion mutants of GM-CSF promoter recombinant constructs. The re
Nature. 1988 Jun 23;333(6175):776-8. Unique Identifier : AIDSLINE MED/88261502
Leung K; Nabel GJ; Howard Hughes Medical Institute, University of Michigan Medical; Center, Department of Internal Medicine, Ann Arbor 48109.
Like other viruses that infect primate cells, the human T lymphotropic virus-I (HTLV-I) stimulates production of some host cell proteins. In particular, HTLV-I infected T cells synthesize interleukin-2 receptor alpha (IL-2R alpha) chain, which is probably induced through the mediation of the tat-I gene product of the
Gilden DH; Murray RS; Wellish M; Kleinschmidt-DeMasters BK; Vafai A; Department of Neurology, Veterans Administration Medical Center,; Denver, CO.
A patient with AIDS developed chronic, progressive encephalitis. Pathologic changes indicated that the encephalitis was produced primarily by a human herpesvirus. Hybridization of radiolabeled RNA probes transcribed from cloned DNA fragments of varicella-zoster virus (VZV), herpes simplex virus,
Pantazis P; Sariban E; Bohan CA; Antoniades HN; Kalyanaraman VS; Center for Blood Research, Boston, Massachusetts 02115.
Human T cells immortalized by human T lymphotropic virus (HTLV)-I and HTLV-II express the genes encoding both chains of platelet-derived growth factor (PDGF). These cells produce biologically active PDGF-like molecules of 31 and 32 kD, identified in the conditioned media of the virus-infected cells by direct immunopre
Ruben S; Poteat H; Tan TH; Kawakami K; Roeder R; Haseltine W; Rosen CA; Department of Molecular Oncology, Roche Institute of Molecular; Biology, Nutley, NJ 07110.
Expression of the interleukin-2 receptor (IL-2R alpha) gene is activated by the transcriptional activator protein, Tax (previously referred to as the tat gene product), encoded by the human T-cell leukemia virus (HTLV-I). Multiple protein binding sites for specific DNA-protein interactions were identified over the ups
Dalgleish AG; Chanh TC; Kennedy RC; Kanda P; Clapham PR; Weiss RA; MRC Clinical Research Centre, Harrow, United Kingdom.
Three IgM monoclonal antibodies raised against synthetic peptide analogs of a hydrophilic region of the gp41 transmembrane env protein of HIV-1 neutralize different HIV-1 isolates but not HIV-2 isolates, as determined by HIV titration and by syncytial inhibition assays. VSV (HIV-1) pseudotypes, however, were not neutr
Nelson JA; Reynolds-Kohler C; Oldstone MB; Wiley CA; Department of Immunology, Research Institute of Scripps Clinic,; La Jolla, California 92037.
Direct interactions at the cellular level in vitro have been reported which suggest that opportunistic viruses may reactivate latent human immunodeficiency virus (HIV) in cells. The significance of these findings depends on whether coinfection of the same cell with these two different types of viruses occurs in vivo.
Fredrikson S; Department of Neurology, Huddinge University Hospital, Karolinska; Institutet, Stockholm, Sweden.
The study aimed to evaluate the usefulness of some selected immune variables as markers of disease activation, progression and possible etiopathogenesis of multiple sclerosis (MS). Levels of neopterin, a factor known to be released from macrophages and monocytes at increased rates in cellular immune reactions were hig
Ann Neurol. 1988 May;23(5):461-5. Unique Identifier : AIDSLINE MED/88267971
Said G; Lacroix-Ciaudo C; Fujimura H; Blas C; Faux N; Service de Neurologie, Hopital de Bicetre (Universite Paris; XI), France.
We have reviewed the clinical and morphological data from 100 patients with necrotizing arteritis in muscle and/or in nerve samples taken by biopsy. The neuropathy occurred in the context of a multisystem disorder (Group 1) or in apparent isolation (Group 2). The average age of patients was 59 in Group 1 and 61 in Gro
Ann Neurol. 1988 May;23(5):485-92. Unique Identifier : AIDSLINE MED/88267975
de la Monte SM; Gabuzda DH; Ho DD; Brown RH Jr; Hedley-Whyte ET; Schooley RT; Hirsch MS; Bhan AK; Department of Pathology, Massachusetts General Hospital, Harvard; Medical School, Boston 02114.
The histopathological and immunopathological features of peripheral neuropathy were investigated in 21 patients with the acquired immunopathological syndrome (AIDS) or AIDS-related complex (ARC). Clinical syndromes observed in the 11 (52%) symptomatic patients include
Oates EL; Allaway GP; Armstrong GR; Boyajian RA; Kehrl JH; Prabhakar BS; Laboratory of Oral Medicine, National Institute of Dental; Research, Bethesda, Maryland 20892.
Expression of the pro-opiomelanocortin (POMC) gene was examined in normal human lymphocytes and lymphocyte cell lines infected by lymphotropic viruses. POMC gene transcripts were detected in human lymphocytes using stringent RNA-RNA hybridizations. Low transcript levels were found in normal phytohemagglutinin-stimulat
Sculley TB; Cross SM; Borrow P; Cooper DA; Queensland Institute of Medical Research, Herston, Brisbane,; Australia.
We measured the presence of antibodies to the Epstein-Barr virus (EBV) nuclear antigen 2B (EBNA2B) in patients with AIDS and related disorders, persons with human immunodeficiency virus (HIV) infection, persons at risk for HIV infection, and normal persons. Sera from 38% (16 of 43) of the patients with AIDS and 35% (4
Appleman ME; Marshall DW; Brey RL; Houk RW; Beatty DC; Winn RE; Melcher GP; Wise MG; Sumaya CV; Boswell RN; Department of Internal Medicine, Wilford Hall U.S. Air Force; Medical Center, Lackland Air Force Base, Texas 78236-5300.
Lumbar punctures were done on 114 consecutive active duty patients referred for evaluation of positive tests for antibodies to the human immunodeficiency virus (HIV). Eighty-eight percent of these patients appeared to have early HIV infections, as evidenced by intact delayed hypersensitivity, T helper lymphocyte count
Montelaro RC; Robey WG; West MD; Issel CJ; Fischinger PJ; Department of Biochemistry, Louisiana State University, Baton; Rouge.
The reported serological relatedness between the major glycoproteins of human immunodeficiency virus (HIV gp120) and equine infectious anaemia virus (EIAV gp90) was examined using purified antigens in radioimmunoprecipitation (RIP), radioimmunoassay (RIA) and immunoblot assays with reference serum from acquired immuno
Hoxie JA; Haggarty BS; Bonser SE; Rackowski JL; Shan H; Kanki PJ; Hematology-Oncology Section, Hospital of the University of; Pennsylvania, Philadelphia 19104.
We have analyzed a number of biological features of HTLV-IV, a retrovirus indistinguishable from a macaque isolate of simian immunodeficiency virus (SIV), and compared this virus with several strains of human immunodeficiency virus type 1 (HIV-1). Although HTLV-IV was found to be similar to HIV-1 in its tropism for CD
Proc Natl Acad Sci U S A. 1988 Jul;85(14):5230-4. Unique Identifier : AIDSLINE MED/88276931
Meruelo D; Lavie G; Lavie D; Department of Pathology, New York University Medical Center, NY; 10016.
Two aromatic polycyclic diones hypericin and pseudohypericin have potent antiretroviral activity; these substances occur in plants of the Hypericum family. Both compounds are highly effective in preventing viral-induced manifestations that follow infections with a variety of retroviruses in vivo and in vitro. Pseudohy
Harbison MA; De Girolami PC; Jenkins RL; Hammer SM; Department of Medicine, New England Deaconess Hospital, Boston,; Massachusetts 02215.
The clinical and virologic efficacy of ganciclovir (9-[1,3-dihydroxy-2-propoxymethyl]guanine) in the treatment of severe CMV infections in solid organ transplant recipients was investigated. Twelve patients (9 liver and 3 kidney transplant recipients) with CMV r
Lee S; Harris C; Hirschfeld A; Dickson DW; Department of Pathology (Neuropathology), Albert Einstein College; of Medicine, Bronx, NY 10461.
Ultrastructural studies of cells and tissues in the acquired immunodeficiency syndrome (AIDS) have revealed two distinct cytomembranous inclusions referred to as tubuloreticular inclusions (TRI) and confronting cylindrical cisterns (CCC). TRI are found most often in leukocytes and endothelial cells in conditions with
Am J Gastroenterol. 1988 Aug;83(8):879-81. Unique Identifier : AIDSLINE MED/88279503
Aaron JS; Wynter CD; Kirton OC; Simko V; Department of Medicine, Brooklyn VA Medical Center, New York.
Cytomegalovirus ( CMV ) is an opportunistic organism known to cause significant gastrointestinal pathology in patients with the acquired immune deficiency syndrome (AIDS). Hepatobiliary involvement has previously been documented. In this report, we discuss the rar
Am J Gastroenterol. 1988 Aug;83(8):885-7. Unique Identifier : AIDSLINE MED/88279505
Rabinowitz M; Bassan I; Robinson MJ; Department of Obstetrics, Mount Sinai Medical Center, Miami; Beach, Florida.
A heterosexual woman with cytomegalovirus ( CMV ) proctitis after anal intercourse is presented. Whereas CMV infection typically occurs in immunosuppressed patients, including patients with acquired immune deficiency syndrome (
Balzarini J; Baba M; Pauwels R; Herdewijn P; De Clerq E; Rega Institute for Medical Research, Katholieke Universiteit; Leuven, Belgium.
The 3 -fluoro-and 3 -azido-substituted derivatives of 2 ,3 -dideoxythymidine (ddThd), 2 ,3 -dideoxyuridine (ddUrd), 2 ,3 -dideoxy-5-ethyluridine (ddEtUrd) and 2 ,3 -dideoxycytidine (ddCyd) have been synthesized and evaluated for their anti-retrovirus activity [against human immunodeficiency virus (HIV) and murine Molo
Martini E; Muller JY; Doinel C; Gastal C; Roquin H; Douay L; Salmon C; Institut National de Transfusions Sanguine, Inserm U76, Paris,; France.
Circadian variations have been observed in peripheral blood lymphocyte counts in normal subjects; they usually reflect variations in absolute CD4-cell count. For this population, nadir occurs around 0800 h (basal value) and the peak value occurs at midnight (1.6 times the 0800-h value). This cycle is thought to be of
Rosoff PM; Savage N; Dinarello CA; Department of Pediatrics, Tufts University School of Medicine,; Boston, Massachusetts 02111.
We have investigated the biochemical mechanism by which interleukin-1 (IL-1) serves as a comitogen with agents that directly activate the antigen receptor in T lymphocytes. We have studied the human T cell line Jurkat, which can be stimulated to produce Interleukin-2 by treatment with antibodies that bind to the CD3-a
Int J Fertil. 1986 Nov-Dec;31(5):356-9. Unique Identifier : AIDSLINE MED/88256467
Kundsin RB; Falk L; Hertig AT; Horne HW Jr; Research Microbiology Laboratory, Brigham and Women's Hospital; Boston, Massachusetts.
One hundred consecutive infertile patients were studied to determine the incidence of sexually transmitted diseases (STDs) among middle and upper income patients, most of whom were referred as longstanding failures by other physicians. There were no cases of syphilis, gonorrhea, or AIDS found among these patients. One
Ikuta K; Morita C; Nakai M; Yamamoto N; Kato S; Department of Pathology, Osaka University.
Persistently HIV-infected cell lines were isolated from surviving and proliferating cells after infection of HTLV-I-carrying MT-4 cells with cell-free human immunodeficiency virus (HIV); HTLV-IIIB and LAV. The media of the cloned cell cultures did not cause HIV infection of MT-4, MOLT-4, TALL-1, or HL-60 cells. Most o
Kagami Y; Kinoshita T; Shimoyama M; Miwa M; Virology Division, National Cancer Center Research Institute,; Tokyo.
Leukemic cells from four out of eight patients with adult T-cell leukemia (ATL) were successfully grown by cocultivation with HSC-I cells, a human skin cancer cell line, in the presence of interleukin-2. Three of these four cultures of growing cells showed rearrangement of the T-cell receptor beta-chain gene like the
Lancet. 1988 Jun 25;1(8600):1418-21. Unique Identifier : AIDSLINE MED/88260435
Lloyd G; Atkinson T; Sutton PM; Division of Pathology, PHLS Centre for Applied Microbiology and; Research, Salisbury, Wiltshire.
Bile salts completely inactivated human immunodeficiency virus type 1 (HIV-1) in vitro and, unexpectedly, completely destroyed all the cultured persistently HIV-1 infected T cells. Fusidic acid, which likewise possesses the properties of an anionic surfactant, inactivated HIV-1 only at concentrations toxic to uninfect
Wilkes MS; Fortin AH; Felix JC; Godwin TA; Thompson WG; Department of Medicine, New York University School of Medicine,; New York.
Necropsy findings in 101 adult patients with the acquired immunodeficiency syndrome (AIDS) from two metropolitan hospitals were compared retrospectively with the antemortem clinical diagnoses. 94% of the patients were male and 68% were homosexual or bisexual. 75 (74%) patients had AIDS-related diseases at necropsy tha
Gessain A; Saal F; Gout O; De-The G; Peries J; Laboratoire de Virologie des Leucemies, LOI CNRS, Hopital; Saint-Louis, Paris, France.
Human T cell leukemia/lymphoma virus type I (HTLV-I) isolated in 1980, is a human retrovirus. This CD4+ lymphotropic type C retrovirus is endemic in South Western Japan , the Caribbean region and Africa where it is associated with a rare form of lymphoproliferative disease, adult T c
Miclea JM; Baurmann H; Gessain A; Ferchal F; Villette D; Rabian C; Daniel MT; Schmidt D; Tea N; Castaigne S; et al; Departement d'Hematologie, LOI CNRS. Paris, France.
We report a case of acute adult T-cell leukemia associated with HTLV1 infection in a young African woman. The leukemic proliferation consisted of CD4-, CD25-positive lymphoid cells with typically convoluted nuclei and monoclonal integration of the HTLV1-proviral DNA. The clinical course was characterized by a rapid pr
Wada H; Tomeoku M; Deguchi A; Suzuki H; Mori Y; Ito M; Deguchi K; Shirakawa S; Department of Internal Medicine, Faculty of Medicine, Mie; University, Japan.
The hemostatic abnormality in 18 patients with adult T cell leukemia (ATL) was studied. Activated partial thromboplastin time (APTT) was slightly prolonged and prekallikrein activity was markedly low in these patients. The leukemic cell homogenate from these patients prolonged the recalcification time (RCT) of normal
Am J Med. 1988 Jul;85(1):51-8. Unique Identifier : AIDSLINE MED/88267254
Weinberg JB; Spiegel RA; Blazey DL; Janssen RS; Kaplan JE; Robert-Guroff M; Popovic M; Matthews TJ; Haynes BF; Palker TJ; Department of Medicine, Veterans Administration Medical Center,; Durham, North Carolina 27705.
PURPOSE: Human adult T-cell leukemia-lymphoma is a malignant, proliferative disease of CD4+ lymphocytes associated with infection with human T-cell lymphotropic virus type I (HTLV-I). Following the presentation of a patient who was infected with the virus, we undertook a study of his family members and sexual contacts
Cancer Res. 1988 Aug 1;48(15):4284-7. Unique Identifier : AIDSLINE MED/88270380
Shirakawa F; Yamashita U; Tanaka Y; Watanaba K; Sato K; Haratake J; Fujihira T; Oda S; Eto S; First Department of Internal Medicine, School of Medicine,; University of Occupational and Environmental Health, Kitakyushu,; Japan.
The physicochemical properties and relationship of bone-resorbing activity and interleukin 1 (IL-1) produced by adult T-cell leukemia (ATL) cells and cell line were studied in vitro. The culture supernatant of ATL cell line, MT2, and peripheral blood lymphocytes freshly obtained from ATL patients had both IL-1 activit
Seniuta NB; Stepina VN; Gurtsevich VE; Mazurin VS; Iakovleva LS
Two immunological tests were used in testing of 808 blood serum samples from inhabitants of Sakhalin and of the city of Yuzhno-Kurilsk for antibodies against HTLV-1 etiologically associated with human T-cell leukemia. Antibodies to HTLV-1 were detected in 4.2% of Nivkhs, 1.2% of Oroks and 1.5% of Russians. The highest
FEBS Lett. 1988 Jul 18;234(2):383-6. Unique Identifier : AIDSLINE MED/88271661
Moriyama Y; Nelson N; Roche Institute of Molecular Biology, Roche Research Center,; Nutley, NJ 07110.
The vacuolar system of eukaryotic cells is energized by a few ATP-driven ion pumps. One of these, the H+-ATPase, plays a major role in providing the protonmotive force for several organelles, as well as maintaining the proper pH inside the organelles. Formation of the protonmotive force in organelles isolated from the
Levine PH; Blattner WA; Clark J; Tarone R; Maloney EM; Murphy EM; Gallo RC; Robert-Guroff M; Saxinger WC; Environmental Epidemiology Branch, National Institutes of Health,; Bethesda, MD 20892.
Epidemiologic studies indicate that human T-cell lymphotropic virus type I (HTLV-I), the causative agent of most cases of adult T-cell leukemia/lymphoma (ATLL) in Southeast Japan and the Caribbean islands and the probable cause of a progressive neurological disorder often referred t
Malik KT; Even J; Karpas A; Department of Haematological Medicine, Cambridge University; Clinical School, U.K.
We report the first complete nucleotide sequence of an adult T cell leukaemia virus/human T cell leukaemia virus type I (ATLV/HTLV-I) isolate from a British patient of Caribbean origin. Sequence comparisons of our proviral clone (HS-35) with other molecular clones are shown. We note the strong sequence conservation be
Shimoyama M; Ota K; Kikuchi M; Yunoki K; Konda S; Takatsuki K; Ichimaru M; Tominaga S; Tsugane S; Minato K; et al; Lymphoma Study Group, National Cancer Center, Tokyo, Japan.
Eighty-one adult patients with advanced T-cell lymphoma/leukemia including 54 with adult T-cell leukemia/lymphoma (ATL), who were treated between 1981 and 1983 with vincristine, cyclophosphamide, prednisolone, and doxorubicin (VEPA) or VEPA plus methotrexate (VEPA-M) in randomized fashion, were evaluated for pretreatm
Faller DV; Crimmins MA; Mentzer SJ; Division of Pediatric Oncology, Dana-Farber Cancer Institute,; Boston, Massachusetts.
The human T-cell leukemia virus type I (HTLV-I) is capable of chronically infecting various types of T cells and nonlymphoid cells. The effects of chronic infection on the specific functional activities and growth requirements of mature cytotoxic T lymphocytes (CTL) have remained poorly defined. We have, therefore, in
Matthews R; Burnie J; Smith D; Clark I; Midgley J; Conolly M; Gazzard B; Department of Medical Microbiology, St Bartholomew's Hospital,; London.
Clinical observation and animal models of candidosis suggest that, although T lymphocytes are important in preventing superficial candidosis, defence against systemic candidosis depends upon humoral immunity. An antibody response to the immunodominant 47 kD antigen of Candida albicans is invariably associated with rec
Ann Intern Med. 1988 Aug 15;109(4):274-9. Unique Identifier : AIDSLINE MED/88280036
Marcon L; Rubin LA; Kurman CC; Fritz ME; Longo DL; Uchiyama T; Edwards BK; Nelson DL; National Institutes of Health, Bethesda, Maryland.
Adult T-cell leukemia associated with human T-cell leukemia virus type I (HTLV-I) is characterized by a clonal expansion of a CD4-positive subset of T lymphocytes that constitutively express high numbers of interleukin-2 receptors and that frequently infiltrate the skin; osteolytic bone lesions, and hypercalcemia. Usi
The cellular receptor for HIV-1 is the leucocyte differentiation antigen, CD4. Blocking of HIV-1 infectivity can be achieved with monoclonal antibodies (MAbs) to some, but not all epitopes of this antigen. We demonstrate here, by inhibition of virus infection, blocking of syncytium formation and inhibition of pseudoty
Shepp DH; Daguillard F; Mann D; Quinnan GV; Division of Virology, Food and Drug Administration, Bethesda,; Maryland.
Vaccines incorporating HIV envelope antigens are being developed for the prevention of AIDS. To determine whether HIV envelope antigens are recognized by human cytotoxic T-lymphocytes (CTL), we assessed class I MHC-restricted, HIV envelope antigen-specific cytotoxic activity of peripheral blood mononuclear cells (PBMC
The testing of sera from patients with AIDS and AIDS-related complex, using ELISA with recombinant env protein produced by E. coli, gave a 94% coincidence with the results obtained on Organon test-system. Sera samples that gave different results in two tests lacked antibodies to env-encoded proteins, as revealed by im
Le SV; Chen JH; Currey KM; Maizel JV Jr; Division of Cancer Biology and Diagnosis, National Cancer; Institute, Frederick, MD 21701.
We describe a program for the analysis of RNA secondary structure. There are two new features in this program. (i) To get vector speeds on a vector pipeline machine (such as Cray X-MP/24) we have vectorized the secondary structure dynamic algorithm. (ii) The statistical significance of a locally optimal secondary st
Peterson A; Seed B; Department of Molecular Biology, Massachusetts General Hospital,; Boston 02114.
Saturation mutagenesis and a complement fixation selection have yielded CD4 point mutants with impaired antibody and human immunodeficiency virus binding. The patterns of amino acid substitution, in conjunction with previous antibody cross-blocking data, affirm the similar tertiary structures of the CD4 amino-terminal
J Med Chem. 1988 Jul;31(7):1475-9. Unique Identifier : AIDSLINE MED/88259160
Webb TR; Mitsuya H; Broder S; Genentech, Inc., South San Francisco, California 94080.
We report here that 1-(2,3-anhydro-beta-D-lyxofuranosyl)cytosine has activity against the human immunodeficiency virus in vitro. A number of 2 ,3 -anhydro-beta-D-lyxofuranosyl nucleoside derivatives were prepared, but none had the activity of the title compound. New efficient procedures were developed for the synthesi
Berzofsky JA; Metabolism Branch, National Cancer Institute, Bethesda, Maryland; 20892.
In contrast to antibodies, T lymphocytes tend to recognize a limited number of immunodominant antigenic sites on a protein antigen. Therefore, the effective design of synthetic or recombinant fragment vaccines would be better approached if these sites could be identified. From studies of the processing and genetically
Lindhardt BO; Ulrich K; Sindrup JH; Avnstorp C; Fogh H; Wantzin GL; Laboratory of Tumor Virology, Fibiger Institute, Copenhagen,; Denmark.
1,182 males and 155 females attending an STD clinic from June 1984 to October 1985 were investigated for the presence of antibodies to human immunodeficiency virus (HIV). 348 (29.5%) of the males and 5 (3.2%) of the females were antibody positive (ab+). 237 of the males were initially antibody negative (ab-) and were
Matthes J; Walker LA; Watson JG; Bird AG; Department of Paediatrics, Newcastle General Hospital.
A 3 year old boy who had acquired HIV infection transplacentally developed the classical features of AIDS encephalopathy, spastic diplegia and expressive aphasia. His computed tomogram showed cerebral atrophy. Treatment with zidovudine and weekly infusions of gammaglobulin led to considerable clinical improvement and
Biochem Pharmacol. 1988 Jun 15;37(12):2395-403. Unique Identifier : AIDSLINE MED/88269002
Balzarini J; Herdewijn P; Pauwels R; Broder S; De Clercq E; Rega Institute for Medical Research, Katholieke Universiteit; Leuven, Belgium.
A series of 5 -phosphorylated derivatives of 3 -azido-2 ,3 -dideoxythymidine (AzddThd), including AzddThd 5 -mono- and 5 -triphosphate, alpha, beta-methylene AzddThd-5 -diphosphate, alpha,beta-methylene AzddThd-5 -triphosphate, and beta,gamma-methylene AzddThd-5 -triphosphate, were evaluated for their cytostatic and a
Henderson LA; Qureshi NM; Rasheed S; Garry R; Department of Microbiology and Immunology, Tulane University; Medical School, New Orleans, Louisiana 70112.
Several aspects of human immunodeficiency virus (HIV)-induced pathology in vitro warrant close examination to ascertain their role in the development of disease in vivo. The ability of HIV to produce cytopathology of CD4 cells has been well documented, although the extent and mechanism(s) may be varied. Further, immun
Proc Natl Acad Sci U S A. 1988 Jul;85(14):5190-4. Unique Identifier : AIDSLINE MED/88276923
Rudd CE; Trevillyan JM; Dasgupta JD; Wong LL; Schlossman SF; Division of Tumor Immunology, Dana-Farber Cancer Institute,; Boston, MA.
The CD4 (T4) antigen is a cell-surface glycoprotein that is expressed predominantly on the surface of helper T cells and has been implicated in the regulation of T-cell activation and in the associative recognition of class II antigens of the major histocompatibility complex. In addition, the CD4 antigen appears to se
Proc Natl Acad Sci U S A. 1988 Jul;85(14):5200-4. Unique Identifier : AIDSLINE MED/88276925
Berman PW; Groopman JE; Gregory T; Clapham PR; Weiss RA; Ferriani R; Riddle L; Shimasaki C; Lucas C; Lasky LA; et al; Department of Molecular Biology, Genentech, Inc., South San; Francisco, CA 94080.
The major envelope glycoprotein, gp120, of human immunodeficiency virus type 1 (HIV-1) was purified from a Chinese hamster ovary cell line transfected with a truncated form of the HIV-1 env gene. The recombinant glycoprotein (rgp120) was formulated with aluminum hydroxide adjuvant and was used to immunize chimpanzees.
Proc Natl Acad Sci U S A. 1988 Jul;85(14):5225-9. Unique Identifier : AIDSLINE MED/88276930
Klasse PJ; Pipkorn R; Blomberg J; Department of Medical Microbiology, Lund University, Sweden.
The IgG response to gp41 (envelope glycoprotein of Mr 41,000) of the human immunodeficiency virus (HIV) was studied with eight synthetic peptides derived from three different regions of the protein. We tested sera from 17 HIV-seronegative and 68 HIV-seropositive subjects in an enzyme immunoassay. No HIV antibody-negat
Am J Hematol. 1988 Jun;28(2):79-84. Unique Identifier : AIDSLINE MED/88279545
Bussel JB; Haimi JS; Department of Pediatrics, New York Hospital--Cornell Medical; Center, NY 10021.
Isolated thrombocytopenia occurs frequently in patients infected with HIV. Studies of mechanisms of thrombocytopenia and clinical response to therapy suggest that the thrombocytopenia is often antibody mediated (ITP). The best approach to treatment of these patients is uncertain in that the routine modalities (steroid
Anand R; Moore JL; Curran JW; Srinivasan A; AIDS Program, Centers for Disease Control, Atlanta, Georgia; 30333.
Rifabutin (ansamycin; LM427), a semisynthetic rifamycin derivative, inhibits the replication of human immunodeficiency virus type 1, the virus etiologically linked to acquired immunodeficiency syndrome. The inhibition of virus production was observed in human immunodeficiency virus type 1-infected peripheral blood mon
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