Important note: Information in this article was accurate in 1988. The state of the art may have changed since the publication date.
MALIGNANT LYMPHOMA IN AIDS
Kaposi's Sarcoma: A Text and Atlas. Gottlieb GJ, Ackerman AB, eds. Philadelphia, Lea and Febiger, p. 213-25, 1988.. Unique Identifier : AIDSLINE ICDB/88647203 Urmacher C; Dept. of Pathology, Memorial Sloan-Kettering Cancer Center, New; York, NY
Abstract:
The main features of malignant lymphoma in acquired immune deficiency syndrome (AIDS) are illustrated via eight selected case reports. The patients (pts) are as follows: a 40-yr-old homosexual man with a history of hepatitis, gonorrhea, syphilis, and condylomata acuminata; a 35-yr-old bisexual man with a history of chronic diarrhea of 6 mo duration; a 26-yr-old homosexual man who had had several hospital admissions for Pneumocystis carinii pneumonia and disseminated infections with Mycobacterium avium-intracellulare; a 38-yr-old homosexual man with Kaposi's sarcoma (KS); a 31-yr-old homosexual admitted for wt loss and malaise, who had a prior history of drug use and venereal disease; a 29-yr-old active homosexual with lymphadenopathy who had a history of repeated venereal infections; a 39-yr-old homosexual man with a cervical mass diagnosed as malignant lymphoma who had a history of repeated venereal infections, drug use, and alcoholism; and a 37-yr-old homosexual man with left axillary adenopathy who had a history of repeated venereal infections and hepatitis. When malignant lymphomas in AIDS are diagnosed clinically, the diagnosis is usually made at an advanced stage and the response to treatment is poor. Compared to non-AIDS pts with malignant lymphoma of the same histologic type and clinical stage, AIDS pts have a higher recurrence rate and mortality and a shorter survival. Histologically, malignant lymphomas in AIDS are characterized by being of intermediate- to high-grade diffuse B cell neoplasias, often of the small noncleaved, undifferentiated variety, showing the chromosomal rearrangements typically seen in Burkitt's lymphoma. Nonlymphomatous lymphadenopathy is a common occurrence in AIDS pts in whom reactive follicular hyperplasia is the most common histologic change, with either a selective paracortical or a total lymphoid depletion in the more advanced stages. In some of the lymph nodes of these pts, human T-lymphotrophic virus type III has been demonstrated. In addition to KS and various opportunistic infections, malignant lymphomas have been included in the 'case definition' of AIDS. (34 Refs)
Keywords: Acquired Immunodeficiency Syndrome/*PATHOLOGY Adult Brain/PATHOLOGY Brain Neoplasms/PATHOLOGY Case Report Homosexuality Human Lymphocytes/PATHOLOGY Lymphoma/*PATHOLOGY Male Neoplasms, Multiple Primary/PATHOLOGY Opportunistic Infections/PATHOLOGY Sarcoma, Kaposi's/PATHOLOGY Skin/PATHOLOGY Skin Neoplasms/PATHOLOGY MONOGRAPH
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Important note: Information in this article was accurate in 1988. The state of the art may have changed since the publication date.
