Important note: Information in this article was accurate in 1988. The state of the art may have changed since the publication date.
ULTRASTRUCTURAL CHANGES IN AIDS AND THEIR ETIOLOGIC SIGNIFICANCE
Kaposi's Sarcoma: A Text and Atlas. Gottlieb GJ, Ackerman AB, eds. Philadelphia, Lea and Febiger, p. 227-38, 1988.. Unique Identifier : AIDSLINE ICDB/88647204 Sidhu GS; Friedman-Kien AE; New York Veterans Association Medical Center, New York, NY
Abstract:
Distinctive cytoplasmic structures found during examination of peripheral blood leukocytes (PBLs) and cells from other tissues of patients (pts) with acquired immune deficiency syndrome (AIDS) are described which could possibly be used as tumor markers and as a method to distinguish pts with Kaposi's sarcoma (KS) of AIDS from pts with the classic form of KS. The material examined came from a group of 38 pts with KS of AIDS and consisted of the following: PBLs (31), cutaneous KS lesions (10), lymph nodes with features of KS (2), cutaneous inflammation (1), hyperplastic lymph nodes (4, 2 with KS), parenchyma of the lung (4), bone marrow (3), liver (2), and colonic mucosa (1). Specimens from cutaneous lesions of four pts with classic KS were also examined. Two types of cytoplasmic structures were found in a variety of cell types from the pts with AIDS: tubuloreticular structures and test-tube and ring-shaped forms. Tubuloreticular structures appeared as collections of branching, anastomosing, hollow tubules about 24 nm in outer diameter, situated within and connected to the membranes of cisternae of the endoplasmic reticulum. Test-tube and ring-shaped forms were composed of two, or rarely more than two, confronting cisternae of endoplasmic reticulum arranged concentrically. They had test-tube shapes in longitudinal sections and ring shapes in cross sections. Both types of cytoplasmic inclusions are diagnostic markers for AIDS. They distinguish the neoplasms from those of classic KS and their presence lends itself to speculation about the cause of the syndrome. Tubuloreticular structures appear in a variety of viral infections in man and animals, in collagen-vascular diseases, globoid leukodystrophy, autoimmune diseases, lymphocytic infiltration of Jessner, and lymphoreticular and other neoplasms. They are most frequent in lupus erythematosus. Test-tube and ring-shaped forms have been described in leukemic lymphocytes of the endemic cells of adult T-cell lymphoma/leukemia seen in Japan, in hepatocytes of man and of chimpanzees with non-A, non-B hepatitis, and in macrophages within lymph nodes of a pt with multiple sclerosis. (56 Refs)
Keywords: Acquired Immunodeficiency Syndrome/*PATHOLOGY Cytoplasm/ULTRASTRUCTURE Human Inclusion Bodies/ULTRASTRUCTURE Leukocytes/ULTRASTRUCTURE Lymph Nodes/ULTRASTRUCTURE Microscopy, Electron Microtubules/ULTRASTRUCTURE Sarcoma, Kaposi's/*ULTRASTRUCTURE Skin/ULTRASTRUCTURE Skin Neoplasms/*ULTRASTRUCTURE MONOGRAPH
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Important note: Information in this article was accurate in 1988. The state of the art may have changed since the publication date.
