AIDS dementia: a review of the literature. NLM AIDSLINE Important note: Information in this article was accurate in 1988. The state of the art may have changed since the publication date.

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AIDS dementia: a review of the literature.

Alzheimer Dis Assoc Disord. 1987;1(4):221-35. Unique Identifier : AIDSLINE MED/88281208
Perry S; Marotta RF; Cornell University Medical College, New York, NY.

Abstract: Mental disturbances associated with acquired immunodeficiency syndrome (AIDS) are related not only to profound psychosocial stress, systemic diseases, and neoplasms or opportunistic infections within the central nervous system (CNS); they are also related to the direct neurotoxicity of the etiologic human immunodeficiency virus (HIV), producing an array of both insidious and acute affective, cognitive, and behavioral dysfunction that can mimic many neuropsychiatric disorders. The precise mechanism of this direct neurotoxicity is not known, nor have the frequency, clinical course, or methods of early diagnosis been clearly established; however, a critique of 56 clinical reviews or case reports regarding approximately 800 subjects suggest that at some point following infection an HIV-induced dementia is extremely common, as are marked histopathological changes throughout the CNS. Treatment strategies are discussed.
Keywords: Acquired Immunodeficiency Syndrome/COMPLICATIONS/DRUG THERAPY/ PATHOLOGY/*PSYCHOLOGY Antiviral Agents/THERAPEUTIC USE Brain/PATHOLOGY Counseling Dementia/DRUG THERAPY/EPIDEMIOLOGY/*ETIOLOGY/PSYCHOLOGY Human Nervous System Diseases/ETIOLOGY Organic Mental Disorders/ETIOLOGY Social Support Support, U.S. Gov't, P.H.S. Thymidine/ANALOGS & DERIVATIVES/THERAPEUTIC USE JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL

KWDacquiredimmunodeficiencysyndrome/complications/drugtherapy/pathology/KWDpsychologyantiviralagents/therapeuticusebrain/pathologycounselingdementia/drugtherapy/epidemiology/KWDetiology/psychologyhumannervoussystemdiseases/etiologyorganicmentaldisorders/etiologysocialsupportsupport,uKWDsKWDgov't,pKWDhKWDsKWDthymidine/analogs&derivatives/therapeuticusejournalarticlereviewreview,tutorial
881130
M88B0574

Copyright © 1988 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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