Autopsy findings in AIDS-related lymphoma. NLM AIDSLINE Important note: Information in this article was accurate in 1988. The state of the art may have changed since the publication date.

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Autopsy findings in AIDS-related lymphoma.

Cancer. 1988 Aug 15;62(4):735-9. Unique Identifier : AIDSLINE MED/88282299
Loureiro C; Gill PS; Meyer PR; Rhodes R; Rarick MU; Levine AM; Department of Internal Medicine, University of Southern; California School of Medicine, Kenneth Norris Jr. Cancer; Hospital, Los Angeles 90033.

Abstract: Autopsies in 20 patients with the acquired immune deficiency syndrome (AIDS)-related lymphoma were studied retrospectively to ascertain the precise cause of death and the extent of lymphomatous disease. Eight patients had primary central nervous system (CNS) lymphoma: two of them were diagnosed antemortem; CNS lymphoma was suspected in three others by computerized tomographic (CT) scan and was confirmed at autopsy. The remaining three were diagnosed incidentally at autopsy. All had concurrent infections at autopsy, including opportunistic infection in six and pyogenic infections in two. Opportunistic infections at autopsy in these patients outnumbered those diagnosed clinically. Twelve patients had systemic lymphoma. Three were diagnosed only at autopsy, two of whom had extensive Kaposi's sarcoma (KS) as well. Eight patients were treated with chemotherapy, but died with disseminated disease. Opportunistic infections were found at autopsy in five patients. Secondary involvement of the CNS by lymphoma was frequent (66%) and was not related to previous bone marrow involvement. The authors conclude that the incidence of lymphoma occurring in AIDS may be more frequent than diagnosed clinically. Similarly, multiple opportunistic infections occur in these patients which are not diagnosed premortem and may contribute to early death.
Keywords: Acquired Immunodeficiency Syndrome/*COMPLICATIONS/PATHOLOGY Adult Autopsy Brain Neoplasms/*COMPLICATIONS Central Nervous System Diseases/COMPLICATIONS Human Lymphoma/*COMPLICATIONS/PATHOLOGY Male Middle Age Opportunistic Infections/*COMPLICATIONS Retrospective Studies JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/KWDcomplications/pathologyadultautopsybrainneoplasms/KWDcomplicationscentralnervoussystemdiseases/complicationshumanlymphoma/KWDcomplications/pathologymalemiddleageopportunisticinfections/KWDcomplicationsretrospectivestudiesjournalarticle
881130
M88B0564

Copyright © 1988 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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