London : Wolfe Medical Publications ; Chicago, Ill. : Year Book Medical Publishers, c1986 77 slides : col. with b&w + 1 guide Unique Identifier : AIDSLINE AV/8801047A
[Bethesda, Md. : Health and Education Resources, 1987] 123 slides : col. + 7 sound cassettes (30 min. each : 1 7/8 ips) + 1 guide (Listen, look, and learn series) Unique Identifier : AIDSLINE AV/8800997A
McDougal JS
(Producer) Lectures contain instructional guides for the continuing education of medical technologists and technicians, most of whom took their original training before the AIDS virus was known. These include objectives, study questions and answers, and references that point the way to an understanding of how all ar
(Producer) A compassionate, professional nursing approach to the complex range of emotional and physical problems faced by the patient with AIDS (Acquired Immune Deficiency Syndrome). In an interview with two AIDS patients, they describe their experiences and reactions to the disease and its profound effects on thei
(Producer) This program solves two of the toughest infection control training problems. The viewer will learn: how AIDS and Hepatitis B affect the body, how the viruses are transmitted, the risk associated with needle sticks, the absence of risk from casual contact, and the four precautions (the CDC recommendations)
New York, N.Y. (622 Third Ave., 34th Floor, New York 10017) : New York Business Group on Health, c1986 v, 86 p Unique Identifier : AIDSLINE CAT/8810141
Atlanta, Ga. : Dept. of Health and Human Services, Public Health Service, Centers for Disease Control, [1986] 40 p. : ill Unique Identifier : AIDSLINE CAT/8810336
Copenhagen : World Health Organization, Regional Office for Europe ; Albany, NY : WHO Publications Centre [distributor], c1987 36 p Unique Identifier : AIDSLINE CAT/8809834
Vaccines 86. New Approaches to Immunization: Developing Vaccines Against Parasitic, Bacterial, and Viral Diseases. Brown F et al, eds. New York, Cold Spring Harbor Laboratory, 418 p., 1986. Unique Identifier : AIDSLINE ICDB/88647931
Anonymous; No affiliation given
Papers reported at the Cold Spring Harbor Laboratory meeting Vaccines 86: New Approaches to Immunization: Developing Vaccines Against Parasitic, Bacterial, and Viral Diseases, are presented. Viruses, pathogenic bacteria, and parasites that cause important diseases are discussed. The volume is divided into the followin
AIDS, Acquired Immune Deficiency Syndrome, and other Manifestations of HIV Infection. Wormser GP et al, eds. Park Ridge, NJ, Noyes Publications, p. 130-59, 1987.. Unique Identifier : AIDSLINE ICDB/88646999
Coffin JM; Dept. of Molecular Biology and Microbiology, Tufts Univ. Sch. of; Medicine, Boston, MA
The discovery that infection with a retrovirus (RV), now called human immunodeficiency virus (HIV), is intimately associated with the causation of the acquired immunodeficiency syndrome (AIDS) is revitalizing interest in studies which consider RVs as infectious pathogens, rather than as transducing agents. Background
AIDS, Acquired Immune Deficiency Syndrome, and other Manifestations of HIV Infection. Wormser GP et al, eds. Park Ridge, NJ, Noyes Publications, p. 767-82, 1987.. Unique Identifier : AIDSLINE ICDB/88647011
Lebovics E; Dworkin BM; Dept. of Medicine, New York Medical Coll., Valhalla, NY
Patients (pts) with acquired immune deficiency syndrome (AIDS) commonly have clinical and histologic hepatic abnormalities, yet human immunodeficiency virus (HIV) infection itself does not appear to have direct effects upon the liver. The recognized liver involvement in AIDS pts relates to (1) coincident hepatotropic
AIDS, Acquired Immune Deficiency Syndrome, and other Manifestations of HIV Infection. Wormser GP et al, eds. Park Ridge, NJ, Noyes Publications, p. 935-47, 1987.. Unique Identifier : AIDSLINE ICDB/88647015
Valsamis MP; Bird S. Coler Hosp., New York Medical Coll., New York, NY
A striking feature of the brain involvement in acquired immunodeficiency syndrome (AIDS) is the multiplicity and variety of infections encountered. The lesions encountered in the nervous system of patients with AIDS are described, including the general concerns of the neuropathologist, bacterial infections, fungal inf
Development and Recognition of the Transformed Cell. Greene MI, Hamaoka T, eds. New York, Plenum, p. 187-202, 1987.. Unique Identifier : AIDSLINE ICDB/88647669
Yoshida M; Seiki M; Fujisawa J; Inoue J; Dept. of Viral Oncology, Japanese Foundation for Cancer Res.,; Tokyo 170, Japan
Animal retroviruses have provided very useful systems for studies on the molecular mechanisms of carcinogenesis. Human T-cell leukemia virus type 1 (HTLV-1), the first human retrovirus to be well characterized, was shown to be associated with a specific human malignancy, adult T-cell leukemia (ATL). Therefore, HTLV-1
Vaccines 87. Modern Approaches to New Vaccines: Prevention of AIDS and Other Viral, Bacterial, and Parasitic Diseases. Chanock RM et al, eds. New York, Cold Spring Harbor Laboratory, 461 p., 1987.. Unique Identifier : AIDSLINE ICDB/88647962
Anonymous; No affiliation given
Annual meetings on Modern Approaches to Vaccines have been held at the Cold Spring Harbor Laboratory since 1983. In 1986, it was decided that the meeting should be extended by one day so that a full discussion of all aspects of acquired immune deficiency syndrome (AIDS) could be included. The shadow of AIDS continues
Vaccines 87. Modern Approaches to New Vaccines: Prevention of AIDS and Other Viral, Bacterial, and Parasitic Diseases. Chanock RM et al, eds. New York, Cold Spring Harbor Laboratory, p. 125-9, 1987.. Unique Identifier : AIDSLINE ICDB/88647965
The recently identified causative agent of acquired immune deficiency syndrome (AIDS) and its prodrome, AIDS-related complex, is a lymphocytopathic retrovirus designated the human immunodeficiency virus (HIV). Regulation of HIV gene expression is complex. The long terminal repeat (LTR) contains several features that a
Vaccines 87. Modern Approaches to New Vaccines: Prevention of AIDS and Other Viral, Bacterial, and Parasitic Diseases. Chanock RM et al, eds. New York, Cold Spring Harbor Laboratory, p. 130-7, 1987.. Unique Identifier : AIDSLINE ICDB/88647966
Sodroski J; Goh WC; Rosen C; Terwilliger E; Dayton A; Campbell K; Haseltine W; Lab. of Biochemical Pharmacology, Dana-Farber Cancer Inst.,; Boston, MA 02115
Acquired immune deficiency syndrome (AIDS) is characterized by marked depletion of the T4+ lymphocyte population in the peripheral blood and involution of the lymph nodes. Infection with the etiologic agent of AIDS (human T-lymphotropic virus type III/lymphadenopathy associated virus, HTLV-III/LAV) can also result in
Vaccines 87. Modern Approaches to New Vaccines: Prevention of AIDS and Other Viral, Bacterial, and Parasitic Diseases. Chanock RM et al, eds. New York, Cold Spring Harbor Laboratory, p. 138-42, 1987.. Unique Identifier : AIDSLINE ICDB/88647967
The etiological agent of acquired immune deficiency syndrome (AIDS), referred to as human T-lymphotropic virus type III (HTLV-III), lymphadenopathy virus (LAV), or human immunodeficiency virus (HIV), is a member of the retrovirus family. HTLV-III shares with HTLV-I and HTLV-II its target cell tropism for the T4 helper
Vaccines 87. Modern Approaches to New Vaccines: Prevention of AIDS and Other Viral, Bacterial, and Parasitic Diseases. Chanock RM et al, eds. New York, Cold Spring Harbor Laboratory, p. 146-53, 1987.. Unique Identifier : AIDSLINE ICDB/88647969
Alizon M; Sonigo P; Wain-Hobson S; Unite de Oncologie Virale, Institut Pasteur, Paris, France
An increasing and diverse number of retroviruses are associated with immunodeficiency syndromes. There are three lentiviruses, the human immunodeficiency viruses (HIV-1 and HIV-2) and the simian immunodeficiency virus (SIV) of rhesus monkeys. In addition, the Mason- Pfizer
Vaccines 87. Modern Approaches to New Vaccines: Prevention of AIDS and Other Viral, Bacterial, and Parasitic Diseases. Chanock RM et al, eds. New York, Cold Spring Harbor Laboratory, p. 154-8, 1987.. Unique Identifier : AIDSLINE ICDB/88647970
Gendelman HE; Martin MA; Lab. of Molecular Biology, NIAID, NIH, Bethesda, MD 20892
Acquired immune deficiency syndrome (AIDS) is etiologically linked to a retrovirus, the human immunodeficiency virus (HIV), that can replicate in exposed individuals for long periods in the absence of clinical disease. As many HIV-infected individuals harbor a variety of microorganisms, the possibility exists that som
Vaccines 87. Modern Approaches to New Vaccines: Prevention of AIDS and Other Viral, Bacterial, and Parasitic Diseases. Chanock RM et al, eds. New York, Cold Spring Harbor Laboratory, p. 159-63, 1987.. Unique Identifier : AIDSLINE ICDB/88647971
Geffin R; Parks ES; Parks WP; Hahn B; Shaw GM; Dept. of Pediatrics, Univ. of Miami Sch. of Medicine, Miami, FL; 33101
Neutralization of the acquired immune deficiency syndrome (AIDS) retrovirus using serum from infected patients has been reported by several laboratories. Investigations were conducted to validate measurement of neutralizing antibodies in an eventual effort to assess the efficacy of neutralizing antibody as a marker of
Vaccines 87. Modern Approaches to New Vaccines: Prevention of AIDS and Other Viral, Bacterial, and Parasitic Diseases. Chanock RM et al, eds. New York, Cold Spring Harbor Laboratory, p. 164-7, 1987.. Unique Identifier : AIDSLINE ICDB/88647972
Fauci AS; Lane HC; Lab. of Immunoregulation, NIAID, NIH, Bethesda, MD 20892
It is now widely recognized that the underlying immunopathogenic event in acquired immune deficiency syndrome (AIDS) is a defect in cell-mediated immunity due to infection of the helper/inducer (T4) subset of T lymphocytes with the etiologic retrovirus, the human immunodeficiency virus (HIV). Only recently has the hos
Vaccines 87. Modern Approaches to New Vaccines: Prevention of AIDS and Other Viral, Bacterial, and Parasitic Diseases. Chanock RM et al, eds. New York, Cold Spring Harbor Laboratory, p. 168-73 , 1987.. Unique Identifier : AIDSLINE ICDB/88647973
Levy JA; Evans L; Pan LZ; Tateno M; Reed MF; Walker C; Homsy J; Cheng-Meyer C; Cancer Res. Inst., Dept. of Medicine, Univ. of California, San; Francisco, CA 94143
The biologic, immunologic, and molecular features of infection by the acquired immune deficiency (AIDS)-associated retrovirus, now called the human immunodeficiency virus-San Francisco (HIV(SF)), were studied. Two specific areas that could influence vaccine development are discussed: biologic heterogeneity of viral is
Vaccines 87. Modern Approaches to New Vaccines: Prevention of AIDS and Other Viral, Bacterial, and Parasitic Diseases. Chanock RM et al, eds. New York, Cold Spring Harbor Laboratory, p. 174-8, 1987.. Unique Identifier : AIDSLINE ICDB/88647974
Clapham PR; Weiss RA; Dalgleish AG; Beverley PC; Sattentau QJ; Lasky LA; Berman PW; Maddon P; Axel R; MacDougal JS; Chester Beatty Laboratories, Inst. of Cancer Res., London, SW3; 6JB, UK
Like other enveloped viruses, the membrane antigens of human immunodeficiency virus type 1 (HIV-1) present targets for neutralizing antibodies and play a key role in the recognition of cell-surface receptors for initial stages of infection. By adapting the vesicular stomatitis virus (VSV) pseudotype technique used for
Vaccines 87. Modern Approaches to New Vaccines: Prevention of AIDS and Other Viral, Bacterial, and Parasitic Diseases. Chanock RM et al, eds. New York, Cold Spring Harbor Laboratory, p. 179-84, 1987.. Unique Identifier : AIDSLINE ICDB/88647975
Clavel F; Guetard D; Chamaret S; Favier V; Alizon M; Montagnier L; Brun-Vezinet F; Klatzmann D; Santos-Ferreira MO; Champalimaud JL; Viral Oncology Unit, Institut Pasteur, Paris, France
Recently, a novel retrovirus was isolated from several acquired immune deficiency syndrome (AIDS) patients (pts) living in different countries of West Africa, an area where the reported incidence of AIDS is low. This virus is clearly related to, but distinct from, HIV and the recently described simian retrovirus SIV (
Vaccines 87. Modern Approaches to New Vaccines: Prevention of AIDS and Other Viral, Bacterial, and Parasitic Diseases. Chanock RM et al, eds. New York, Cold Spring Harbor Laboratory, p. 185-7, 1987.. Unique Identifier : AIDSLINE ICDB/88647976
Kanki PJ; Essex M; Barin F; Dept. of Cancer Biology, Harvard Sch. of Public Health, Boston,; MA 02115
Recently, new T-lymphotropic retroviruses were described in Old World primates, including especially healthy wild-caught African green monkeys and ill colony-raised macaques. These viruses were designated the simian T-lymphotropic viruses type III (STLV-III) because of their similarities to human T-lymphotropic virus
Vaccines 87. Modern Approaches to New Vaccines: Prevention of AIDS and Other Viral, Bacterial, and Parasitic Diseases. Chanock RM et al, eds. New York, Cold Spring Harbor Laboratory, p. 188-93, 1987.. Unique Identifier : AIDSLINE ICDB/88647977
Rosen J; Hom YL; Whalley A; Smith R; Naso RB; Johnson and Johnson Biotechnology Center, La Jolla, CA 92038
Human immunodeficiency virus (HIV) is generally accepted as the etiologic agent responsible for acquired immune deficiency syndrome (AIDS) and its associated disorders. The serum of most patients (pts) diagnosed with AIDS or AIDS-related complex (ARC), as well as HIV-infected individuals with no apparent disease, cont
Vaccines 87. Modern Approaches to New Vaccines: Prevention of AIDS and Other Viral, Bacterial, and Parasitic Diseases. Chanock RM et al, eds. New York, Cold Spring Harbor Laboratory, p. 194-8, 1987.. Unique Identifier : AIDSLINE ICDB/88647978
Prince AM; Pascual D; Kurokawa D; Baker L; Lab. of Virology, Lindsley F. Kimball Res. Inst. of the New York; Blood Center, New York, NY 10021
The extraordinary variability in the sequence of envelope genes of human immunodeficiency virus strains has raised concern that concomitant antigenic variation might prevent potential vaccines from achieving broad protective efficacy. To address this question, quantitative neutralization assays were carried out using
Vaccines 87. Modern Approaches to New Vaccines: Prevention of AIDS and Other Viral, Bacterial, and Parasitic Diseases. Chanock RM et al, eds. New York, Cold Spring Harbor Laboratory, p. 205-8, 1987.. Unique Identifier : AIDSLINE ICDB/88647979
Fultz PN; Switzer W; McGrath N; Srinivasan A; McClure HM; Brodie A; Swenson B; AIDS Program, Centers for Disease Control, Atlanta, GA 30333
Animal models have been developed to aid in testing potential vaccines for protection against infection by immunodeficiency viruses of human and simian origin. These model systems include infection of chimpanzees with various strains of human immunodeficiency virus (HIV), the causative agent of acquired immune deficie
Vaccines 87. Modern Approaches to New Vaccines: Prevention of AIDS and Other Viral, Bacterial, and Parasitic Diseases. Chanock RM et al, eds. New York, Cold Spring Harbor Laboratory, p. 214-24, 1987.. Unique Identifier : AIDSLINE ICDB/88647981
Yarchoan R; Broder S; Clinical Oncology Program, Div. of Cancer Treatment, NCI,; Bethesda, MD 20892
The discovery of human T-cell lymphotropic virus type III (HTLV-III) as the cause of acquired immune deficiency syndrome (AIDS) permitted consideration of therapy directed against the causative viral agent. The most striking clinical feature in AIDS is the development of a variety of unusual opportunistic infections a
Vaccines 87. Modern Approaches to New Vaccines: Prevention of AIDS and Other Viral, Bacterial, and Parasitic Diseases. Chanock RM et al, eds. New York, Cold Spring Harbor Laboratory, p. 225-30, 1987.. Unique Identifier : AIDSLINE ICDB/88647982
Krohn K; Robey WG; Putney S; Talle MA; Ranki A; Lab. of Tumor Cell Biology, NCI, Bethesda, MD 20892
Theoretically, three characteristics of human immunodeficiency virus (HIV) might explain the lack of protective immunity in infected individuals: (1) infection of cells, such as macrophages and helper T cells, which play a key role in host s immune response toward foreign microorganisms, (2) immunosuppressive viral mo
Vaccines 87. Modern Approaches to New Vaccines: Prevention of AIDS and Other Viral, Bacterial, and Parasitic Diseases. Chanock RM et al, eds. New York, Cold Spring Harbor Laboratory, p. 231-5, 1987.. Unique Identifier : AIDSLINE ICDB/88647983
Hu SL; Moran PA; McClure J; Kosowski SG; Zarling JM; Morton W; Oncogen and Genetics Systems Corp., Seattle, WA 98121
Vaccinia virus has been used successfully as a vector for the expression of a variety of foreign genes. The potential use of recombinant vaccinia virus as a live vaccine against several infectious diseases has also been indicated. This technology could be applied for possible development of an acquired immune deficien
Vaccines 87. Modern Approaches to New Vaccines: Prevention of AIDS and Other Viral, Bacterial, and Parasitic Diseases. Chanock RM et al, eds. New York, Cold Spring Harbor Laboratory, p. 236-41, 1987.. Unique Identifier : AIDSLINE ICDB/88647984
Steimer KS; Van Nest G; Dina D; Barr PJ; Luciw PA; Miller ET; Chiron Corp., Emeryville, CA 94608
The development of a vaccine for human immunodeficiency virus (HIV), the etiological agent of acquired immune deficiency syndrome (AIDS), is one of the highest priorities in biomedical research. One approach is to use viral polypeptides produced in genetically engineered microorganisms as subunit vaccine. To obtain su
Vaccines 87. Modern Approaches to New Vaccines: Prevention of AIDS and Other Viral, Bacterial, and Parasitic Diseases. Chanock RM et al, eds. New York, Cold Spring Harbor Laboratory, p. 242-9, 1987.. Unique Identifier : AIDSLINE ICDB/88647985
Kieny MP; Rautmann G; Lecocq JP; Wain-Hobson S; Montagnier L; Girard M; Transgene S.A., 67000 Strasbourg, France
The human immunodeficiency virus (HIV), a novel retrovirus, is now recognized as the causative agent of acquired immune deficiency syndrome (AIDS). HIV exhibits a characteristic tropism for T4 lymphocytes, although both macrophages and neural tissue can also be infected. AIDS patients (pts) suffer from severe immunosu
Vaccines 87. Modern Approaches to New Vaccines: Prevention of AIDS and Other Viral, Bacterial, and Parasitic Diseases. Chanock RM et al, eds. New York, Cold Spring Harbor Laboratory, p. 256-9, 1987.. Unique Identifier : AIDSLINE ICDB/88647987
Putney SD; Javaherian K; Jackson J; Lynn D; Rusche J; Mueller WT; Matthews T; Bolognesi D; Ghrayeb J; Chanda PK; et al; RepliGen Corp., Cambridge, MA 02139
Several different approaches are being taken toward the development of an acquired immune deficiency syndrome (AIDS) vaccine. The most promising of these appears to be immunization with a form of the outer viral envelope protein, gp120, and recombinant vehicles engineered to express this protein have included Escheric
Vaccines 87. Modern Approaches to New Vaccines: Prevention of AIDS and Other Viral, Bacterial, and Parasitic Diseases. Chanock RM et al, eds. New York, Cold Spring Harbor Laboratory, p. 260-2, 1987.. Unique Identifier : AIDSLINE ICDB/88647988
Gardner M; Marx P; Lerche N; Maul D; Sutjipto S; Kwang HS; Pederson N; Dept. of Medical Pathology, California Regional Primate Center,; Univ. of California, Davis, CA 95616
Simian acquired immunodeficiency syndrome (SAIDS) is a spontaneous, often fatal disease that occurs in eight species of Asian macaques at four primate research centers in the United States . Because of the practical importance of this disease and because fatal SAIDS could be repeatedly
Vaccines 87. Modern Approaches to New Vaccines: Prevention of AIDS and Other Viral, Bacterial, and Parasitic Diseases. Chanock RM et al, eds. New York, Cold Spring Harbor Laboratory, p. 268-72, 1987.. Unique Identifier : AIDSLINE ICDB/88647990
The discovery that members of the retrovirus family cause human leukemia and acquired immune deficiency syndrome (AIDS) has generated an interest in the development of vaccines against retroviruses. The murine model of leukemia caused by the Friend virus complex (FV) was chosen to study the potential for immune protec
Kaposi's Sarcoma: A Text and Atlas. Gottlieb GJ, Ackerman AB, eds. Philadelphia, Lea and Febiger, 330 p., 1988.. Unique Identifier : AIDSLINE ICDB/88647193
Anonymous; No affiliation given
This volume aims to comprehensively discuss Kaposi s sarcoma (KS), a previously rare disorder now receiving attention because of its association with acquired immune deficiency syndrome (AIDS). Topics include: the history of KS, a short biography of Moritz Kaposi, etymology of the name Kaposi, an atlas of gross and mi
Kaposi's Sarcoma: A Text and Atlas. Gottlieb GJ, Ackerman AB, eds. Philadelphia, Lea and Febiger, p. 3-7, 1988.. Unique Identifier : AIDSLINE ICDB/88647194
Rosai J; Dept. of Surgical Pathology, Yale Univ. Sch. of Medicine, New; Haven, CT
From the time of its discovery, Kaposi s sarcoma (KS) has proven difficult to classify, and its exact nature remains unknown today. It is obvious that KS is related to the vascular system, but whether it is a proliferative disease primarily of the lymph vessels or blood vessels and whether the affected cells are endot
Kaposi's Sarcoma: A Text and Atlas. Gottlieb GJ, Ackerman AB, eds. Philadelphia, Lea and Febiger, p. 29-71, 1988.. Unique Identifier : AIDSLINE ICDB/88647195
Ackerman AB; Gottlieb GJ; New York Univ. Sch. of Medicine, New York, NY
The appearance of Kaposi s sarcoma (KS) at the gross and microscopic level is described and illustrated, including four color plates showing the gross appearance of skin lesions. Lesions of KS present first as pinpoint macules. In time, such macules may enlarge horizontally and become patches or may enlarge vertically
Kaposi's Sarcoma: A Text and Atlas. Gottlieb GJ, Ackerman AB, eds. Philadelphia, Lea and Febiger, p. 73-110, 1988.. Unique Identifier : AIDSLINE ICDB/88647196
Gottlieb GJ; Ackerman AB; Dept. of Anatomic Pathology, William Beaumont Hosp., Royal Oak,; MI
Characteristics of conditions that mimic or are mimicked by Kaposi s sarcoma (KS) are described. Color plates show the appearance on the skin of the following: ecchymosis, stasis changes, malignant melanoma, granuloma annulare, insect bites, secondary syphilis, lichen planus, hypertrophic lichen planus, dermatofibroma
Kaposi's Sarcoma: A Text and Atlas. Gottlieb GJ, Ackerman AB, eds. Philadelphia, Lea and Febiger, p. 113-27, 1988.. Unique Identifier : AIDSLINE ICDB/88647197
Amazon K; Rywlin AM; Dept. of Pathology, Mount Sinai Medical Center, Miami Beach, FL
Systemic manifestations of Kaposi s sarcoma (KS) are described and illustrated by micrographs. After the skin, the organs most frequently involved by KS are lymph nodes and the gastrointestinal (GI) tract. Enlarged lymph nodes in patients (pts) with KS may have different histologic appearances. Whenever hypervascular
Kaposi's Sarcoma: A Text and Atlas. Gottlieb GJ, Ackerman AB, eds. Philadelphia, Lea and Febiger, p. 129-40, 1988.. Unique Identifier : AIDSLINE ICDB/88647198
Waldo E; Sidhu GS; New York Veterans Administration Medical Center, New York, NY
The electron microscopic characteristics of Kaposi s sarcoma (KS) in both acquired immune deficiency syndrome (AIDS) and non-AIDS patients (pts) are described and illustrated. Criteria for differentiating KS from its simulators (histiocytoid hemangioma, hemangioma, and sclerosing hemangioma [dermatofibroma]) are discu
Kaposi's Sarcoma: A Text and Atlas. Gottlieb GJ, Ackerman AB, eds. Philadelphia, Lea and Febiger, p. 151-70, 1988.. Unique Identifier : AIDSLINE ICDB/88647200
Bayley AC; Dept. of Surgery, Univ. of Zambia, Lusaka, Zambia
The epidemiologic, clinical, and pathologic characteristics of endemic Kaposi s sarcoma (KS) and atypical aggressive KS in Africa are reviewed, and the characteristics distinguishing these two disorders are discussed and tabulated. Clinical features of atypical aggressive KS are described in detail and histories from
Kaposi's Sarcoma: A Text and Atlas. Gottlieb GJ, Ackerman AB, eds. Philadelphia, Lea and Febiger, p. 179-96, 1988.. Unique Identifier : AIDSLINE ICDB/88647201
Greene JB; Schrager LK; New York Univ. Sch. of Medicine, New York, NY
Diagnosis of the infectious diseases associated with acquired immune deficiency syndrome (AIDS) is discussed in terms of general principles, infections considered to be diagnostic for AIDS, and infections commonly associated with AIDS but not regarded as diagnostic. Five color plates illustrate the pathologic and clin
Kaposi's Sarcoma: A Text and Atlas. Gottlieb GJ, Ackerman AB, eds. Philadelphia, Lea and Febiger, p. 213-25, 1988.. Unique Identifier : AIDSLINE ICDB/88647203
Urmacher C; Dept. of Pathology, Memorial Sloan-Kettering Cancer Center, New; York, NY
The main features of malignant lymphoma in acquired immune deficiency syndrome (AIDS) are illustrated via eight selected case reports. The patients (pts) are as follows: a 40-yr-old homosexual man with a history of hepatitis, gonorrhea, syphilis, and condylomata acuminata; a 35-yr-old bisexual man with a history of ch
Kaposi's Sarcoma: A Text and Atlas. Gottlieb GJ, Ackerman AB, eds. Philadelphia, Lea and Febiger, p. 227-38, 1988.. Unique Identifier : AIDSLINE ICDB/88647204
Sidhu GS; Friedman-Kien AE; New York Veterans Association Medical Center, New York, NY
Distinctive cytoplasmic structures found during examination of peripheral blood leukocytes (PBLs) and cells from other tissues of patients (pts) with acquired immune deficiency syndrome (AIDS) are described which could possibly be used as tumor markers and as a method to distinguish pts with Kaposi s sarcoma (KS) of A
Kaposi's Sarcoma: A Text and Atlas. Gottlieb GJ, Ackerman AB, eds. Philadelphia, Lea and Febiger, p. 255-69, 1988.. Unique Identifier : AIDSLINE ICDB/88647206
Collier AC; Handsfield EH; Dept. of Medicine, Univ. of Washington Sch. of Medicine, Seattle,; WA
The epidemiology of Kaposi s sarcoma (KS) is reviewed under the following headings: clinical classification, incidence and geographic distribution, age distribution, sex distribution, ethnic and genetic associations, associations between immunodeficiency and neoplasia, association with
Kaposi's Sarcoma: A Text and Atlas. Gottlieb GJ, Ackerman AB, eds. Philadelphia, Lea and Febiger, p. 271-87, 1988.. Unique Identifier : AIDSLINE ICDB/88647207
Niedt GW; Schinella RA; Dept. of Pathology, New York Univ. Sch. of Medicine, New York, NY
Findings in 56 patients (pts) with acquired immune deficiency syndrome (AIDS) who were autopsied by the authors and in published autopsy reports are reviewed. At autopsy, pts with AIDS usually are young men about 40 yr old. Most are homosexuals, but some are iv drug abusers or Haitians, and a few belong to two or more
Vaccines 87. Modern Approaches to New Vaccines: Prevention of AIDS and Other Viral, Bacterial, and Parasitic Diseases. Chanock RM et al, eds. New York, Cold Spring Harbor Laboratory, p. 143-5, 1987.. Unique Identifier : AIDSLINE ICDB/88647968
A cell line (8E5) was cloned containing a defective proviral genome that constitutively produces acquired immune deficiency syndrome (AIDS) viral particles. When culture supernatants from the 8E5 cell line were collected and tested for the presence of AIDS viral antigens by an antigen-capture method, it was found that
Vaccines 87. Modern Approaches to New Vaccines: Prevention of AIDS and Other Viral, Bacterial, and Parasitic Diseases. Chanock RM et al, eds. New York, Cold Spring Harbor Laboratory, p. 209-13, 1987.. Unique Identifier : AIDSLINE ICDB/88647980
Letvin NL; Daniel MD; King NW; Kiyotaki M; Kannagi M; Chalifoux LV; Sehgal PK; Desrosiers RC; Arthur LO; Allison AC; Harvard Medical Sch., New England Regional Primate Res. Center,; Southborough, MA 01772
A T-cell tropic lentivirus with striking similarities to the human immunodeficiency virus (HIV) has been isolated from macaque monkeys at the New England Regional Primate Research Center. This lentivirus has been isolated from peripheral blood lymphocytes (PBLs) of animals with the macaque immunodeficiency syndrome, f
Vaccines 87. Modern Approaches to New Vaccines: Prevention of AIDS and Other Viral, Bacterial, and Parasitic Diseases. Chanock RM et al, eds. New York, Cold Spring Harbor Laboratory, p. 250-5, 1987.. Unique Identifier : AIDSLINE ICDB/88647986
Kennedy RC; Kanda P; Dreesman GR; Eichberg JW; Chanh TC; Ho DD; Sparrow JT; Dept. of Virology and Immunology, Southwest Foundation for; Biomedical Res., San Antonio, TX 78284
Studies have demonstrated that the most immunogenic component of human immunodeficiency virus (HIV) in infected individuals is the envelope glycoprotein (gp160). The predicted amino acid sequences of gp160 have been deduced by cloning the envelope proteins of several HIV isolates. Comparison of the amino acid sequence
Vaccines 87. Modern Approaches to New Vaccines: Prevention of AIDS and Other Viral, Bacterial, and Parasitic Diseases. Chanock RM et al, eds. New York, Cold Spring Harbor Laboratory, p. 263-7, 1987.. Unique Identifier : AIDSLINE ICDB/88647989
Elder JH; McGee J; Munson M; Houghten R; Bittle J; Grant C; Dept. of Molecular Biology, Res. Foundation of Scripps Clinic, La; Jolla, CA 92037
The feline leukemia viruses (FeLVs) are a polymorphic family of retroviruses found associated with malignant and degenerative diseases of the cat. Although animals infected with FeLV may eventually develop leukemias and lymphosarcomas, the most prevalent problem is an immunodeficiency syndrome, not unlike that associa
IMA J Math Appl Med Biol. 1986;3(4):229-63. Unique Identifier : AIDSLINE MED/88285926
Anderson RM; Medley GF; May RM; Johnson AM; Department of Pure and Applied Biology, Imperial College,; University of London.
The paper describes some preliminary attempts to formulate simple mathematical models of the transmission dynamics of HIV infection in homosexual communities. In conjunction with a survey of the available epidemiological data on HIV infection and the incidence of AIDS, the models are used to assess how various process
LAV-HTLV III serologic out-patient s supervision (clinical an immunological status), general practitioner and family medicine practitioners are able to follow up out-patients with a positive LAV-HTLV III serology. However the lack of IgM LAV-HTLV III serology is not enable to make secure our patients about the RETRO-V
Perry S; Marotta RF; Cornell University Medical College, New York, NY.
Mental disturbances associated with acquired immunodeficiency syndrome (AIDS) are related not only to profound psychosocial stress, systemic diseases, and neoplasms or opportunistic infections within the central nervous system (CNS); they are also related to the direct neurotoxicity of the etiologic human immunodefici
Cavallo G; Cavallo R; Istituto di Microbiologia, Universita di Torino.
Based on the various viral properties, the recent Retrovirus classifications are reported. After describing the HIV characteristics with the transactivation capability, the authors include the HIV among the Lentivirinae.
Rolston KV; Bodey GP; Department of Internal Medicine, University of Texas M.D.; Anderson Hospital and Tumor Institute, Houston 77030.
The acquired immunodeficiency syndrome (AIDS) was recognized as a distinct clinical entity in 1981 and was characterized by unexplained opportunistic infections and an aggressive form of Kaposi s sarcoma. High risk groups for contracting AIDS include homosexual men, parenteral drug users, hemophiliacs, recipients of b
AIDS Res Hum Retroviruses. 1988 Jun;4(3):159-64. Unique Identifier : AIDSLINE MED/88281277
Johnson PR; Parks DE; Norrby E; Lerner RA; Purcell RH; Chanock RM; Laboratory of Infectious Diseases, National Institute of Allergy; and Infectious Diseases, Bethesda, MD.
The transmembrane glycoprotein (gp32) of the simian immunodeficiency virus (SIV) contains a highly antigenic region that includes amino acid residues 606-628. A synthetic peptide representing this region was highly immunoreactive with sera from SIV-infected primates in a site-directed enzyme-linked immunosorbent assay
AIDS Res Hum Retroviruses. 1988 Jun;4(3):165-73. Unique Identifier : AIDSLINE GENBANK/J03653
Yourno J; Josephs SF; Reitz M; Zagury D; Wong-Staal F; Gallo RC; Wadsworth Center for Laboratories and Research, New York State; Department of Health.
As a further step in the continuing process of defining the extent and nature of variability of the envelope (env) gene of HIV-1, we have cloned a new Zairian isolate, JY1, and sequenced the env gene of this isolate. Although the restriction map of the env region of JY1 was found to be more similar to that of the Amer
AIDS Res Hum Retroviruses. 1988 Jun;4(3):233-6. Unique Identifier : AIDSLINE MED/88281284
Roumelioutou-Karayannis A; Nestoridou K; Mandalaki T; Stefanou T; Papaevangelou G; Department of Epidemiology and Medical Statistics, Athens School; of Hygiene, Greece.
To provide further evidence for the heterosexual transmission of the acquired immunodeficiency syndrome (AIDS) in Greece we examined 53 Greek female steady heterosexual partners of 53 anti-HIV-positive men. Human immunodeficiency vi
Cancer. 1988 Aug 15;62(4):735-9. Unique Identifier : AIDSLINE MED/88282299
Loureiro C; Gill PS; Meyer PR; Rhodes R; Rarick MU; Levine AM; Department of Internal Medicine, University of Southern; California School of Medicine, Kenneth Norris Jr. Cancer; Hospital, Los Angeles 90033.
Autopsies in 20 patients with the acquired immune deficiency syndrome (AIDS)-related lymphoma were studied retrospectively to ascertain the precise cause of death and the extent of lymphomatous disease. Eight patients had primary central nervous system (CNS) lymphoma: two of them were diagnosed antemortem;
Gabuzda DH; Levy SR; Chiappa KH; Department of Neurology, Massachusetts General Hospital, Boston; 02114.
EEG records from 47 patients with the acquired immunodeficiency syndrome (AIDS) or AIDS-related complex (ARC) were reviewed retrospectively to correlate EEG findings with neurologic abnormalities. Abnormal EEGs were found in 22 of 33 (67%) patients with AIDS and 5 of 14 (36%) patients with ARC. Among 27 patients with
Assogba U; Park RA; Rey MA; Barthelemy A; Rottembourg J; Gluckman JC; Department of Nephrology, Hopital Pitie-Salpetriere, Paris,; France.
A prospective multicenter study was undertaken between February 1985 and August 1986 in 4 hemodialysis centers in the Paris area ( France ) in order to assess the prevalence of HIV I infection and the risk of transmission of the virus within the centers. A four-month follow-up was ca
Webb JG; Chan-Yan C; Kiess MC; Department of Medicine, University of British Columbia, St.; Paul's Hospital, Vancouver, Canada.
Five patients with acquired immune deficiency syndrome (AIDS) developed clinical evidence of mild to severe cardiac dysfunction confirmed by nuclear angiography and echocardiography. In 4 patients who were studied postmortem there was no evidence of myocarditis, valvular, or ischemic heart disease. Cardiac involvement
Fifty-one intravenous drug abusers were evaluated by a pulmonary consultative team over a 22-month period at a large inner city hospital. The most common pulmonary complication was septic pulmonary embolism, seen in 12 patients (23.5 percent). Community-acquired pneumonia was diagnosed in ten patients (19.6 percent).
Krueger JJ; Sayre VA; Karetzky MS; UMDNJ-New Jersey Medical School, Newark Beth Israel Medical; Center.
Bronchoalveolar lavage (BAL) has not been associated with the complication of pneumothorax. Candidates for this procedure are predisposed to develop pneumothorax due to underlying infectious interstitial emphysema. This risk factor is increased by the hyperbaric consequences of lavage and also by the cough induced by
Murakawa GJ; Zaia JA; Spallone PA; Stephens DA; Kaplan BE; Wallace RB; Rossi JJ; Department of Microbiology, University of California, Los Angeles; 90024.
Human immunodeficiency virus (HIV), formerly termed human T-lymphotropic virus (HTLVIII/LAV), is the etiological agent of acquired immune deficiency syndrome (AIDS). Direct detection of HIV-1 nucleic acid sequences in patient tissue or blood samples is possible in only a minor fraction of cases due to the low percenta
Aymard JP; Janot C; Briquel ME; Schooneman F; Legras B; Alexandre P; Streiff F; Regional Blood Transfusion Centre, Vandoevre, France.
Blood lymphocyte proliferative responses to mitogens were studied in 65 patients with haemophilia (haemophilia A: 54 patients, haemophilia B: 11 patients) in parallel with 39 male control subjects. As a group, patients with haemophilia did not demonstrate abnormal proliferative responses to phytohaemagglutinin (PHA),
Costa B; Tacconi P; Cannas A; Pinna L; Fiaschi A; I Clinica Neurologica, Universita di Cagliari.
In a patient with AIDS presenting partial epilepsy cerebral toxoplasmosis was diagnosed on the serological and CT evidence. The diagnosis was confirmed by the immediate response to sulfonamide therapy.
JAMA. 1988 Aug 19;260(7):935-8. Unique Identifier : AIDSLINE MED/88286970
Hull HF; Bettinger CJ; Gallaher MM; Keller NM; Wilson J; Mertz GJ; New Mexico Health and Environment Department, Santa Fe; 87504-0968.
All patients attending a sexually transmitted disease (STD) clinic were offered voluntary, anonymous human immunodeficiency virus (HIV)-antibody testing and counseling as part of routine clinical evaluation. During a three-month evaluation period, 82% of patients accepted HIV testing. Testing was accepted equally by m
Med Hypotheses. 1988 May;26(1):89-91. Unique Identifier : AIDSLINE MED/88288097
Montella F; Centro per lo studio dell'AIDS e delle Sindromi correlate, USL RM; IX, Osp, S. Giovanni, Roma, Italia.
Many clinicians have realised that AIDS is only the most dreadful aspect of HIV infection. Together with the asymptomatic carrier condition, other syndromes have been described, including LAS, ARC and Lesser-AIDS. We have developed a working hypothesis to explain the natural history of HIV infection, basing our assump
McLaughlin M; Thomas P; Onorato I; Rubinstein A; Oleske J; Nicholas S; Krasinski K; Guigli P; Orenstein W; New York City Department of Health, Division of Medical Affairs,; NY 10013.
Live virus vaccines can cause serious adverse reactions when administered to immunocompromised patients. Because children infected with human immunodeficiency virus (HIV) may be immunosuppressed, immunization of these children with live virus vaccines is a potential problem. A retrospective survey was conducted by the
Henrion R; Clinique Universitaire de Port-Royal, Paris.
The authors discuss the numerous problems currently raised by women and children affected by the HIV virus. After a short reminder of the virus characteristics and the epidemiology, they study the mothers risk by discussing a possible aggravation of the disease during pregnancy, and the risks for the child, by consid
Valle SL; Department of Dermatology, University of Helsinki, Finland.
High rates of sexually transmitted diseases (STDs) were recorded among 235 homosexually active men at the start of a prospective follow-up study in June 1983 in Finland . The vast majority (88.5%) reported at least one STD, the most
Gotzsche PC; Hording M; Department of Infectious Diseases, Rigshospitalet, Copenhagen,; Denmark.
30 female prostitutes and 16 persons from the hospital staff each tested 10 latex condoms by vaginal intercourse. Six dropped out. Condom rupture occurred at least once for 7/40 persons (95% confidence interval 7-33%). Total condom rupture rate was 5%. Although encouragement to condom use is prudent in an epidemiologi
Des Jarlais DC; Friedman SR; New York State Division of Substance Abuse Services, New York,; New York 10047.
There is strong epidemiologic evidence from studies of i.v. drug users in New York City for the existence of one or more gender-related cofactors in response to HIV infection. The strength of the evidence comes from the variety of data sets that indicate a gender-related cofactor and from the consistency of the patter
Am J Med. 1988 Aug;85(2):152-8. Unique Identifier : AIDSLINE MED/88292365
Johnson PC; Khardori N; Najjar AF; Butt F; Mansell PW; Sarosi GA; Department of Internal Medicine, University of Texas Health; Science Center, Houston 77030.
PURPOSE: Progressive disseminated histoplasmosis is now diagnosed frequently in patients with the acquired immunodeficiency syndrome (AIDS) living in the central United States . Previous review articles of AIDS have failed to mention this infection. Herein, we describe 48 AIDS patients
Am J Med. 1988 Aug;85(2):172-6. Unique Identifier : AIDSLINE MED/88292368
Jacobson MA; Gellermann H; Chambers H; Department of Medicine, University of California, San Francisco.
PURPOSE: An increased incidence of Staphylococcus aureus bacteremia has recently been described in patients with the acquired immunodeficiency syndrome (AIDS). However, other risk factors for community-acquired S. aureus bacteremia (including intravenous drug abuse and lymphedema) were present in nearly all these AIDS
Kaplowitz LG; Turshen IJ; Myers PS; Staloch LA; Berry AJ; Settle JT; Department of Medicine, Medical College of Virginia, Richmond; 23298-0049.
This study examines inpatient charges for 52 adult patients with the acquired immunodeficiency syndrome (AIDS) who had 102 admissions to the Medical College of Virginia Hospitals, Richmond, from October 1983 through December 1986. Complete charge data were available for 81 hospitalizations; the mean charge per hospita
Edelman MJ; Oldfield EC; Department of Internal Medicine, Naval Hospital, San Diego, CA; 92134-5000.
Cryptosporidiosis is increasingly recognized as a significant human pathogen. Previous reports have emphasized the benign, self-limited nature of the illness in the immunocompetent adult. In contrast, immunodeficient hosts have severe, frequently unremitting illness. We describe a case in which an individual, with no
Ozel M; Pauli G; Gelderblom HR; Robert Koch-Institut des Bundesgesundheitsamtes, Berlin.
The organization of envelope projections (knobs) of four different isolates of the human immunodeficiency virus types 1 and 2 (HIV-1 and -2) was studied using surface replica and thin section electron microscopy (EM) in combination with rotational image enhancement. All HIV strains show an identical organization of kn
Mansour AM; Jampol LM; Logani S; Read J; Henderly D; Department of Ophthalmology, University of Texas Medical Branch,; Galveston.
The cotton-wool spot is a common fundus finding in patients with many ocular and systemic diseases. We investigated the characteristics of cotton-wool spots in patients with four major diseases, ie, acquired immunodeficiency syndrome, diabetes mellitus, systemic hypertension, and central retinal vein occlusion, to see
Barriga F; Whang-Peng J; Lee E; Morrow C; Jaffe E; Cossman J; Magrath IT; Pediatric Branch, National Cancer Institute, Bethesda, MD 20892.
We have studied, at a molecular level, two small non-cleaved cell malignant lymphomas (Burkitt s type) that were separated by a disease-free interval of 3 years in a patient infected with the human immunodeficiency virus (HIV). The late occurrence of the apparent relapse suggested that the second lymphoma might be cau
Hamori E; Varga G; Department of Biochemistry, Tulane Medical School, New Orleans,; LA 70112.
The complete nucleotide sequences of several human immunodeficiency virus 1 (HIV-1) genomes were converted by computer to respective H curves. These three-dimensional space curves embody all the information contained in the sequence due to their abstract vectorial structure. For one sequence (HIV-1 isolate BRU) specia
Kingston D; Division of Communicable Diseases, Clinical Research Centre,; Harrow, UK.
Bacteriological studies on the communion cup have shown that there is a low level of contamination with mouth organisms on the rim. The death rate of bacteria on the cup surface would not be significant, but the wine had a bactericidal effect on most but not all organisms tested. However droplets of saliva did not rea
de Souza Ramalho P; Hormigo A; Martins R; Saldanha C; Martins-Silvas J; Department of Ophthalmology, University of Lisbon, Portugal.
Two selected cases of retinal vasculitis, apparently of unknown aetiology, are reported; one case without any systemic or laboratory manifestation and the second case with a clinical picture similar to VKH syndrome and immunodepression. Both cases showed abnormal haematological parameters related to blood viscosity in
The paper describes the psychiatric status on the basis of 76 patients with acquired immune deficiency syndrome. There is considerable difference between the different stages of the disease. The disorders are divided into groups following the German and French psychopathological tradition, where the incidence is depen
Hosp Community Psychiatry. 1988 Jun;39(6):628-31. Unique Identifier : AIDSLINE MED/88297572
Fernandez F; Levy JK; Galizzi H; Baylor College of Medicine, Houston, Texas.
Four depressed and cognitively impaired patients with HIV-related disease had a marked therapeutic response to treatment with psychostimulants. Use of dextroamphetamine and methylphenidate brought a prompt remission of depressive and cognitive dysfunctions without adverse side effects. The results suggest the need for
Graham AR; Sobonya RE; Bronnimann DA; Galgiani JN; Dept of Pathology, University of Arizona Health Sciences Center,; Tucson 85724.
This study examines the laboratory aspects of diagnosis of coccidioidomycosis in 11 patients with acquired immunodeficiency syndrome (AIDS) and the qualitative and quantitative differences between host responses of AIDS and non-AIDS patients who died with disseminate
Cooper JS; Sacco J; Newall J; New York University Medical Center, NY.
We report the short- and long-term responses to radiotherapy of 82 classic Kaposi s sarcomas. Doses were prescribed ab initio and no attempt was made to discontinue treatment as soon as shrinkage was observed, as has been recommended by others. More than 50% of the lesions regressed completely and nearly all underwent
Though there is no correlation between mental illness and homosexuality, there are unique concerns that play a role in symptomatology and psychotherapy around neurotic and characterological issues in gay patients. Homophobia, both in the therapist and in the patient, external and internalized, is the significant hidde
Davidson BL; Kline RL; Rowland J; Quinn TC; School of Hygiene and Public Health (Division of Infectious; Diseases), Johns Hopkins University, Baltimore, Maryland.
Mehler MF; Saul R. Korey Department of Neurology, Albert Einstein College of; Medicine, Bronx, New York.
The term ocular bobbing defines a distinctive class of abnormal spontaneous vertical eye movements which occur in a variety of clinicopathological settings. Four cardinal forms, which correspond to the predicted permutations of the two characteristic clinical variables, initial vertical excursion and phasic velocity,
Stamm WE; Handsfield HH; Rompalo AM; Ashley RL; Roberts PL; Corey L; Department of Medicine, University of Washington School of; Medicine, Seattle.
We analyzed the association of herpes simplex virus (HSV) infection and syphilis, the two most common causes of genital ulceration in homosexual men, with human immunodeficiency virus (HIV) infection in 200 men enrolled between 1983 and 1986 into a study evaluating the microbial causes of acute proctitis. Infection wi
Li WH; Tanimura M; Sharp PM; Center for Demographic and Population Genetics, University of; Texas, Houston 77225.
The acquired immune deficiency syndrome (AIDS), caused by a retrovirus called human immunodeficiency virus (HIV), has become a pandemic. A knowledge of the rate of nucleotide substitution in HIV and of the history and pattern of spread of the virus is important for understanding the epidemiology and pathogenesis of AI
Nature. 1988 Aug 4;334(6181):440-4. Unique Identifier : AIDSLINE GENBANK
Saag MS; Hahn BH; Gibbons J; Li Y; Parks ES; Parks WP; Shaw GM; Department of Internal Medicine, University of Alabama,; Birmingham 35294.
Genotypic variation among independent isolates of human immunodeficiency virus type-1 (HIV-1) is well known, but its molecular basis and biological consequences are poorly understood. We examined the genesis of molecular variation in HIV-1 by sequential virus isolations from two chronically infected individuals and an
NIPH Ann. 1988 Jun;11(1):19-28. Unique Identifier : AIDSLINE MED/88302768
Kraft P; Rise J; National Institute of Public Health, Oslo.
This paper studied different kinds of knowledge related to HIV/AIDS in the adult Norwegian population. The empirical basis stems from two national interview surveys conducted in 1986. Data were analysed using contingency table analysis and multiple classification analysis (MCA). Totally, 64% knew that HIV/AIDS is caus
NIPH Ann. 1988 Jun;11(1):9-18. Unique Identifier : AIDSLINE MED/88302771
Kraft P; Rise J; National Institute of Public Health, Oslo.
The present paper deals with three issues related to public opinion in Norway : 1) the importance and credibility of HIV/AIDS information sources; 2) changes or intended changes of sexual behaviour because of fear of HIV/AIDS and, 3) attitudes towards homosexuals and the integrity o
Van de Perre P; Bakkers E; Batungwanayo J; Kestelyn P; Lepage P; Nzaramba D; Bogaerts J; Serufilira A; Rouvroy D; Uwimana A; et al; AIDS project, Belgian-Rwandese Medical Cooperation, Kigali,; Rwanda.
During a 3-month period, 131 cases of herpes zoster were diagnosed in Kigali, Rwanda . There were 46 female and 85 male patients. Mean age was 29 years (range 1-66). An unusually high proportion of patients presented with cranial and sacral nerve localisation of their cutaneous lesi
Sonnerborg A; Carlin G; Akerlund B; Jarstrand C; Department of Infectious Diseases, Roslagstull Hospital,; Stockholm, Sweden.
The mean plasma content of malondialdehyde (MDA) in 30 patients in different stages of HIV infection was found to be about 30% higher than that in controls. The phenomenon was not correlated to the degree of immunodeficiency and was noted early in the course of the disease. This indicates a higher degree of basal lipi
S Afr Med J. 1988 Aug 20;74(4):153-7. Unique Identifier : AIDSLINE MED/88305618
Schoub BD; Smith AN; Lyons SF; Johnson S; Martin DJ; McGillivray G; Padayachee GN; Naidoo S; Fisher EL; Hurwitz HS; Department of National Health and Population Development,; National Institute for Virology, Johannesburg.
Limited epidemiological data on acquired immunodeficiency syndrome (AIDS) and human immunodeficiency virus (HIV) infection have been assembled by voluntarily reported AIDS figures, blood donor serum prevalence and high-risk sentinel population and random background population sero-prevalence studies. The HIV epidemic
Z Hautkr. 1988 Jun 15;63(6):517-20. Unique Identifier : AIDSLINE MED/88306487
Winzer M; Gilliar U; Klinik fur Dermatologie und Venerologie der Medizinischen; Universitat zu Lubeck.
10 specimens taken from oral hairy leukoplakia were compared to 8 histological preparations from hairy tongue. We found 9 criteria helpful concerning the histopathologic differential diagnosis of these entities. Oral hairy leukoplakia shows a gently papillated surface, a prominent horny layer with confluent bacterial
Mizusawa H; Hirano A; Llena F; Department of Pathology, Montefiore Medical Center, Bronx, NY; 10467.
Six cases of subacute encephalitis in AIDS were examined with special reference to the nuclear morphology of multinucleated giant cells (MGC s). Although rare in some, all cases showed nuclear bridges which were thin strands connecting individual nuclei. Even more frequently observed were nuclear processes which were
Am J Hematol. 1988 Jul;28(3):184-5. Unique Identifier : AIDSLINE MED/88307348
Sweeney JD; Hassett JM; Hemophilia Center of Western New York, Buffalo.
A 42-year-old patient with hemophilia A developed acute left hypochondrial pain 8 days postnephrolithotomy. A colloidal scan indicated multiple hematomas, and conservative management was given. Postoperatively, recurrent discomfort necessitated splenectomy. Multiple space-occupying lesions were found, and the histolog
Am J Med. 1988 Feb;84(2):215-7. Unique Identifier : AIDSLINE MED/88307375
Anaissie E; Fainstein V; Samo T; Bodey GP; Sarosi GA; Department of Medical Specialties, University of Texas System; Cancer Center, M. D. Anderson Hospital and Tumor Institute,; Houston 77030.
Involvement of the central nervous system (CNS) by Histoplasma capsulatum is a rare event. It is usually not included in the differential diagnosis of CNS lesions in patients with acquired immunodeficiency syndrome (AIDS). Herein are described four patients with AIDS and progressive disseminated histoplasmosis who had
Am J Med. 1988 Feb;84(2):307-9. Unique Identifier : AIDSLINE MED/88307388
Rosenthal PJ; Chaisson RE; Hadley WK; Leech JH; Medical Service, San Francisco General Hospital, University of; California 94110.
A severe rectal lesion due to Leishmania infection is described in an American-born homosexual man with the acquired immunodeficiency syndrome. The infection, which may have been venereally transmitted, responded to treatment with amphotericin B. There was no evidence of visceral leishmaniasis. The contribution of the
Am J Med. 1988 Aug 29;85(2A):3-6. Unique Identifier : AIDSLINE MED/88307438
Thin RN; Department of Genito-urinary Medicine, St. Thomas' Hospital,; London, United Kingdom.
Genital herpes simplex infection is a common and troublesome condition that is more often due to herpes simplex type II virus than to type I virus. The first step in management is accurate diagnosis by virus culture or antigen recognition. General management involves explaining the natural history to the patient, givi
Am J Med. 1988 Aug 29;85(2A):53-6. Unique Identifier : AIDSLINE MED/88307445
Gill MJ; Arlette J; Tyrrell DL; Buchan KA; Department of Medicine, University of Calgary, Alberta, Canada.
Herpes simplex virus (HSV) infection of the hand occurs predominantly in three different population groups. Young adults with a recurrent HSV II infection of the hand account for the majority of cases. A prodromal phase of up to 72 hours and a recurrence of seven to 10 days duration occasionally associated with lymph
Am J Public Health. 1988 Sep;78(9):1210-2. Unique Identifier : AIDSLINE MED/88307733
Henry K; Department of Medicine, St. Paul-Ramsey Medical Center, MN 55101.
The approach to the acquired immune deficiency syndrome (AIDS) taken by public health departments and clinicians varies. Public health programs often neglect the human side of AIDS while clinicians often overlook public health issues. Current research on AIDS has failed to address many fundamental questions including:
Ann Ophthalmol. 1988 May;20(5):191-2, 195. Unique Identifier : AIDSLINE MED/88308163
Yassur Y; Biedner B; Fabrikant M; Department of Ophthalmology, Soroka University Hospital, Faculty; of Health Sciences, Ben-Gurion University of the Negev,; Beer-Sheva, Israel.
Ax W; Research Laboratories of Behringwerke AG, Marburg, W.-Germany.
Monoclonal antibodies against cellular antigens are of extreme specificity, reproducibility and in principle can be made available in unlimited amounts. In cellular diagnosis the application of monoclonal antibodies became already established. Different methods to target the reaction of these antibodies, with the corr
Espinoza LR; Berman A; Vasey FB; Cahalin C; Nelson R; Germain BF; Department of Internal Medicine, College of Medicine, University; of South Florida, Tampa.
We describe 2 patients who developed psoriatic arthritis during the course of acquired immunodeficiency syndrome. Both patients developed skin and articular involvement characteristic of psoriatic arthritis; these manifestations were refractory to conventional therapy. Our findings suggest that psoriatic arthritis sho
Keeter S; Bradford JB; Survey Research Laboratory, Virginia Commonwealth University,; Richmond 23284-3016.
Interviews regarding AIDS knowledge and related behavior change were conducted with a random sample of 409 unmarried individuals 18-39 years of age in Richmond, Virginia, between March 18 and April 3, 1987. Eight percent of the sample described themselves as gay or bisexual, 92% as heterosexual (or straight). Key vari
AIDS Res Hum Retroviruses. 1988 Jun;4(3):211-21. Unique Identifier : AIDSLINE MED/88281282
Gallo P; De Rossi A; Amadori A; Tavolato B; Chieco-Bianchi L; Institute of Neurology, University of Padova, Italy.
Central nervous system (CNS) involvement occurs frequently in patients with the acquired immunodeficiency syndrome (AIDS), but at present only a few reports have addressed the analysis of intrathecal IgG synthesis in human immunodeficiency virus (HIV)-seropositive patients with no signs of HIV-related neurologic syndr
AIDS Res Hum Retroviruses. 1988 Jun;4(3):223-31. Unique Identifier : AIDSLINE MED/88281283
Ragni MV; O'Brien TA; Reed D; Spero JA; Lewis JH; Department of Medicine, University of Pittsburgh School of; Medicine, PA.
Antibodies to specific HIV viral antigens were measured by ELISA recombinant proteins representing gag and env amino acid sequences of human immunodeficiency virus (HIV) (E. I. du Pont de Nemours, Wilmington, DE) and by a Western blot system using biotinavidin detection (Biotech Research Labs, Rockville, MD) on 36 HIV
The surveillance of the epidemic of infection with the human immunodeficiency virus (HIV) in the United Kingdom is described. Up to 30 September 1987, 1067 cases meeting the World Health Organization /Centers for Disease Control (U.S.A.) definition of th
Lumerman H; Freedman PD; Kerpel SM; Phelan JA; Booth Memorial Medical Center, Flushing, N.Y.
A total of 3970 cases of Kaposi s sarcoma (KS) associated with the acquired immunodeficiency syndrome had been reported to the Centers for Disease Control by the end of 1986. The prevalence of oral KS in patients with KS of the skin varies, reaching a maximum of 44% in one published study. We present a retrospective c
Phelan JA; Klein RS; Department of Oral Medicine, New York University College of; Dentistry.
This report presents a case of oral hairy leukoplakia that has completely disappeared during treatment with azidothymidine. The reason for the resolution of the lesions in this case is not certain, but the outcome may be due to the action of the drug on the agent or agents causing the lesion.
Berntorp E; Schulman S; Nilsson IM; Department of Coagulation Disorders, University of Lund, Malmo; General Hospital, Sweden.
In order to evaluate the risk of HIV transmission during conception or pregnancy from seropositive male haemophiliacs to their children, we have investigated the families of 8 HIV antibody positive haemophilia A patients. HIV antibodies could be demonstrated in 1/9 mothers after delivery of her second child, whereas a
S Afr Med J. 1988 Aug 6;74(3):104-5. Unique Identifier : AIDSLINE MED/88290855
O'Farrell N; Windsor I; Department of Sexually Transmitted Disease, City Health; Department, King Edward VIII Hospital, Durban.
The prevalence of antibodies to the human immunodeficiency virus among recurrent attenders at a sexually transmitted disease clinic for blacks was investigated. Of 140 tested 4 subjects were seropositive and had no other known risk factors.
Yala F; Olembe C; M'Pele P; Rosenheim M; Service de Microbiologie et d'Immunologie, Hopital General de; Brazzaville.
Serum samples taken from 6,624 blood donors since 1984 to 1987, were tested for Hepatitis B virus surface antigen (HBs Ag) using a microhemagglutination assay and for anti-HIV antibodies by ELISA test. The mean carrier state of HBs Ag was 10.68% and that of anti-HIV antibodies was 6.99%. The association of HBs Ag and
McCauley KR; Gerbert BJ; Greene JC; Robertson PB; Littlejohn C; Greenspan D; Greenspan JS; Department of Oral Biology, School of Dentistry, University of; California, San Francisco 94143-0512.
The emergence of AIDS has alerted the nation s health care community to the dangers of occupational transmission of infectious disease. This article assesses the risk of occupational transmission in the health care setting and examines two prevention strategies: vaccination programs and infection control protocols. Th
Klin Wochenschr. 1988 Jun 1;66(11):488-93. Unique Identifier : AIDSLINE MED/88301529
Schulte C; Meurer M; Braun-Falco O; Held M; Froschl M; Dermatologische Klinik und Poliklinik,; Ludwig-Maximilians-Universitat Munchen.
The western blot analysis of 170 patients with HIV-1-infection demonstrated that 47% of the patients in latent stage, 58% of the patients with lymphadenopathy-syndrome and only 25% of the patients with the full-blown picture of AIDS showed the complete pattern of HIV-specific antibody response. This antibody response
Am J Med. 1988 Aug 29;85(2A):189-94. Unique Identifier : AIDSLINE MED/88307432
Blum MR; Liao SH; Good SS; de Miranda P; Department of Medical Biochemistry, Wellcome Research; Laboratories, Research Triangle Park, North Carolina 27709.
The basic pharmacokinetic and bioavailability information on zidovudine was obtained during the initial phase I study. Following intravenous doses of 1.0 mg/kg every eight hours to 7.5 mg/kg every four hours, zidovudine plasma levels decay in a biexponential manner, indicating two-compartment pharmacokinetics. The mea
Am J Med. 1988 Aug 29;85(2A):203-7. Unique Identifier : AIDSLINE MED/88307435
Blanche S; Caniglia M; Fischer A; Rouzioux C; Burgard M; Tardieu M; Duhamel G; Griscelli C; Departement de Pediatrie, Hopital Necker, Paris, France.
Eight children with acquired immunodeficiency syndrome (AIDS), aged four months to 12 years, were treated with zidovudine (azidothymidine) 100 mg/m2 intravenously every six hours for 14 days, followed by oral zidovudine at the same dose for a total of six months. Of the eight, six were infected at birth and two were c
Packer SJ; Cesario T; Williams JH Jr; University of California, Irvine Medical Center, Orange.
Infections caused by Mycobacterium avium in relatively immunocompetent hosts usually occur with isolated pulmonary involvement. Patients with the acquired immunodeficiency syndrome (AIDS) more commonly have disseminated disease. Endobronchial masses, however, have not been described with M. avium complex infections in
Krupka U; Research Laboratories of Behringwerke AG, Marburg, W.-Germany.
Based on the competitive principle a new enzyme linked immunosorbent assay (ELISA) was developed for the reliable detection of Anti HIV. By introducing a sequential competitive procedure a detection limit of Anti HIV was achieved, which exceeded Western blot analysis by factor 8 to 16 as measured with dilutions of 14
AIDS Res Hum Retroviruses. 1988 Jun;4(3):199-210. Unique Identifier : AIDSLINE MED/88281281
Wahren B; Chiodi F; Ljunggren K; Putney S; Kurth R; Gallo RC; Fenyo EM; Department of Virology, National Bacteriological Laboratory,; Stockholm, Sweden.
A model system was established for studies of humoral and cellular immunity to human immunodeficiency virus (HIV) antigens after vaccination. Macaques (Macaca fascicularis) were immunized with purified HIV, an infected cell extract rich in gp120 or polypeptides of cloned genes representing parts of p24, gp41, and gp12
Abd AG; Nierman DM; Ilowite JS; Pierson RN Jr; Bell AL Jr; Department of Medicine, St. Luke's Roosevelt Hospital Center, New; York.
A 46-year-old man with AIDS, receiving inhaled pentamidine for Pneumocystis carinii pneumonia (PCP) prophylaxis, developed bilateral upper lobe infiltrates. Bronchoalveolar lavage confirmed the diagnosis of PCP. Therapy with intravenous trimethoprim-sulfamethoxazole (TMP-SMX) was begun, with gradual resolution of thes
Rich EA; Toossi Z; Fujiwara H; Hanigosky R; Lederman MM; Ellner JJ; Department of Medicine, University Hospitals, Cleveland, OH; 44106-5000.
It is not clear whether the accessory function of monocytes from subjects with human immunodeficiency virus (HIV)-related diseases such as acquired immunodeficiency syndrome (AIDS) and persistent generalized lymphadenopathy (PGL) is intact. In this study, the accessory function of monocytes from healthy subjects (n =
Barre-Sinoussi F; Laboratory of Retroviruses Unit, Institut Pasteur, Paris, France.
Pathogenesis of HIV infection and expression of retroviral proteins are gradually being elucidated. Antibody to HIV is a marker of past or present viral infection. The virus can be isolated from cultured lymphocytes of seropositive but not seronegative patients. Sero-epidemiological studies show that the majority of i
Diebold J; Audouin J; Le Tourneau A; Service Central J. Delarue d'Anatomie et de Cytologie; Pathologique, Faculty de Medecine Broussais, Paris, France.
Vernon DD; Holzman BH; Lewis P; Scott GB; Birriel JA; Scott MB; Department of Pediatrics, University of Miami.
Acute respiratory failure has a high mortality in patients with acquired immunodeficiency syndrome (AIDS). This study was undertaken to determine the etiology of acute respiratory failure and the outcome of children with AIDS and AIDS-related complex. Records of 31 children with AIDS or AIDS-related complex admitted t
Cauda R; Tumbarello M; Ortona L; Kanda P; Kennedy RC; Chanh TC; Istituto Clinica Malattie Infettive, Universita Cattolica del S.; Cuore, Rome, Italy.
The inhibitory effect on normal natural killer (NK) cell activity of two synthetic peptides corresponding to amino acid sequences 735-752 and 846-860, respectively, as deduced from the amino acid sequences of HTLV-IIIB gp160, was assessed. Sequences 735-752 and 846-860 correspond to regions located within the HIV tran
Pohl P; Vogl G; Fill H; Rossler H; Zangerle R; Gerstenbrand F; Neurological Department, University of Innsbruck, Austria.
Single photon emission computed tomography (SPECT) studies were performed in AIDS dementia complex using IMP in 12 patients (and HM-PAO in four of these same patients). In all patients, SPECT revealed either multiple or focal uptake defects, the latter corresponding with focal sign
Nature. 1988 Aug 18;334(6183):620-3. Unique Identifier : AIDSLINE MED/88302464
Fowlkes BJ; Schwartz RH; Pardoll DM; Laboratory of Cellular and Molecular Immunology, National; Institute of Allergy and Infectious Diseases, Bethesda, Maryland; 20894.
As T cells develop in the thymus, they become tolerant of self-antigens. A major advance in the understanding of how this process occurs was the direct demonstration that cells bearing autoreactive T-cell receptors (TCRs) are physically eliminated from the population of functionally mature T cells present in both the
Esptein LG; DiCarlo FJ Jr; Joshi VV; Connor EM; Oleske JM; Kay D; Koenigsberger MR; Sharer LR; Department of Neurosciences, University of Medicine and; Dentistry-New Jersey Medical School, Newark 07103-2757.
Three children with acquired immunodeficiency syndrome and primary lymphoma of the CNS are described. All three children had clinical signs of focal mass lesions and progressive neurologic deficits. In one child the deterioration was extremely rapid. New lesions appeared on serial CT scans every few days, simulating a
S Afr Med J. 1988 Aug 20;74(4):157-60. Unique Identifier : AIDSLINE MED/88305619
Raal FJ; Wypkema EM; Baynes RD; Department of Medicine, Johannesburg Hospital.
Full haematological data were available on 22 of the first 30 patients with proven acquired immunodeficiency syndrome (AIDS) admitted to Johannesburg Hospital before July 1987. Reversal of the helper/suppressor T-cell ratio was present in all cases and polyclonal hypergammaglobulinaemia in 85% of cases. Sixty-eight pe
Am J Med. 1988 Feb;84(2):303-6. Unique Identifier : AIDSLINE MED/88307387
Gallant JE; Enriquez RE; Cohen KL; Hammers LW; Department of Medicine, West Haven Veterans Administration; Medical Center, Connecticut.
A 38-year-old black man with a history of acquired immunodeficiency syndrome associated with intravenous drug abuse presented with two weeks of left-sided neck swelling. Results of thyroid function tests were within normal limits. Thyroid scan demonstrated nonvisualization of the left lobe. Fine-needle aspiration of t
Breda SD; Hammerschlag PE; Gigliotti F; Schinella R; Department of Otolaryngology, New York University Medical Center,; New York.
Extrapulmonary infection with Pneumocystis carinii is rare and is usually associated with severe systemic illness. We report, in two patients, the histologic, ultrastructural, and monoclonal cell surface antibody identification of P carinii in otic polyps. Both patients had serum antibody to human immunodeficiency vir
Garry RF; Gottlieb AA; Zuckerman KP; Pace JR; Frank TW; Bostick DA; Department of Microbiology and Immunology, Tulane University; School of Medicine, New Orleans, Louisiana.
Cell killing by human immunodeficiency virus (HIV) is thought to contribute to many of the defects of the acquired immunodeficiency syndrome (AIDS). Two types of cytopathology are observed in HIV-infected cultured cells: cell-cell fusion and killing of single cells. Both killing processes appear to involve cell surfac
Schneider J; Kent SB; Division of Biology, California Institute of Technology, Pasadena; 91125.
A protein corresponding to the putative protease of the human immunodeficiency virus 1 (HIV-1) has been prepared by total chemical synthesis. This 99 residue synthetic enzyme showed specific proteolytic activity on fragments of the natural gag precursor and on synthetic peptide substrates, two of which released fragme
Of 234 patients with AIDS diagnosed at St. Stephen s Hospital between January 1981 and June 1987, 26 (11%) were found to have cryptosporidiosis. Stool examination was positive in all patients, but an average of three specimens (range 1-6) were required before a positive diagnosis was made. Other methods of diagnosis i
Dal Conte I; Lucchini A; Giuliani G; Ayres L; Avillez MF; Gilgen D; Karpas A; Center for Drug Abusers, National Health Service, U.S.L.I.,; Turin, Italy.
We have compared the Karpas AIDS Cell Test for antibodies to the human immunodeficiency viruses (HIV) with a commercial enzyme-linked immunosorbent assay (ELISA) (Organon Teknika) by testing serum samples from 324 intravenous drug abusers in Turin. The cell test was found to be more sensitive and as specific as the EL
Peto TE; Bull R; Millard PR; Mackenzie DW; Campbell CK; Haines ME; Mitchell RG; Nuffield Department of Clinical Medicine, John Radcliffe; Hospital, Oxford, U.K.
Systemic mycosis due to Penicillium marneffei is described in a man infected with human immunodeficiency virus and who had travelled in S.W. China . He responded completely to treatment with amphotericin B and a prolonged course of ketoconazole. Problems of diagnosis are discussed an
J Natl Cancer Inst. 1988 Aug 17;80(12):900-11. Unique Identifier : AIDSLINE MED/88286772
Gail MH; Brookmeyer R; Epidemiologic Methods Section, National Cancer Institute,; Bethesda, MD 20892.
Three methods for projecting the short-term course of the acquired immunodeficiency syndrome (AIDS) epidemic are discussed: (a) empirical extrapolation, (b) the method of back calculation, and (c) projections based on compartmental models. Extrapolation, which requires only data on AIDS incidence, is based on an assum
Tutschka PJ; Department of Medicine, Ohio State University, Columbus 43210.
After allogeneic bone marrow transplantation certain patterns of infectious complications emerge that follow the clinical course, are correlated to the immunobiology of transplantation and are almost predictable in their character and expression. The preparative regimen, designed to generate complete aplasia, will be
Pahwa S; Department of Pediatrics, North Shore University Hospital,; Manhasset, NY 11030.
The causative agent of acquired immunodeficiency syndrome is a retrovirus, human T lymphotropic virus type III/lymphadenopathy-associated virus, now known as human immunodeficiency virus (HIV). Infection of children with HIV results in a wide spectrum of clinical manifestations, ranging from asymptomatic to symptomati
Salva KM; Kim HC; Nahum K; Fallot PL; Department of Oncology, Montefiore Medical Center, Bronx, New; York 10467.
Hemophilia A and von Willebrand s disease are hereditary disorders associated with qualitative and quantitative abnormalities of clotting factor VIII. A major clinical feature is excessive or abnormal bleeding often necessitating the use of transfusions of pooled blood products to achieve hemostasis. Exposure to blood
Walsh TJ; Hamilton SR; Belitsos N; Infectious Diseases Section, National Cancer Institute, Bethesda,; MD 20892.
Esophageal candidiasis is an opportunistic infection that is being recognized increasingly often in certain patients, including those who have a neoplastic disease, are undergoing protracted antibiotic therapy, or hae acquired immunodeficiency syndrome (AIDS). Impaired cell-mediated immunity may predispose the patient
Proc Natl Acad Sci U S A. 1988 Aug;85(15):5507-11. Unique Identifier : AIDSLINE MED/88289750
Goodchild J; Agrawal S; Civeira MP; Sarin PS; Sun D; Zamecnik PC; Worcester Foundation for Experimental Biology, Shrewsbury, MA; 01545.
Twenty different target sites within human immunodeficiency virus (HIV) RNA were selected for studies of inhibition of HIV replication by antisense oligonucleotides. Target sites were selected based on their potential capacity to block recognition functions during viral replication. Antisense oligomers complementary t
Busk MF; Rosenow EC 3d; Wilson WR; Mayo Medical School, Mayo Foundation, Rochester, MN 55905.
The etiology of respiratory infections can be elusive despite the recent advances in diagnostic technology. Thereby, the clinician needs a systematic approach for a definitive early diagnosis. This review presents the pros and cons of various invasive procedures in order to select the most appropriate diagnostic metho
Berk SL; Verghese A; Veterans Administration Medical Center, Medical Service, Johnson; City, TN 37684.
With few exceptions, the parasitic pneumonias most commonly encountered in the Western Hemisphere are diseases of compromised hosts; patients with AIDS are at particular risk. Pneumocystis carinii pneumonia occurs eventually in 80% of AIDS patients; bronchoalveolar lavage is quite sensitive in establishing this diagno
Bourgoignie JJ; Meneses R; Ortiz C; Jaffe D; Pardo V; Department of Medicine, University of Miami School of Medicine,; FL 33101.
A nephrology consultation was called on 100 adult patients of 1,635 (6.1%) patients with human immunodeficiency virus (HIV) infection seen between 1982 and 1987 at the University of Miami/Jackson Memorial Medical Center. Renal disease was observed in all groups of patients with a risk factor for HIV infection with a l
Langer R; Langer M; Schutze B; Wakat JP; Zwicker C; Felix R; Radiologische Klinik und Poliklinik, Klinikum; Rudolf-Virchow-Standort Charlottenburg, Freie Universitat; Berlin.
The ultrasonographic findings of 43 patients with AIDS and ARC were analyzed. In 63% an enlarged liver, in 66% an enlarged spleen, partially with focal lesions, and in 21% enlarged abdominal lymph nodes were diagnosed. The typical parenchymal lesions of the kidney (focal segmental glomerulosclerosis) were not observed
Comodo N; Martinelli F; De Majo E; Colao MG; Di Pietro MA; Manescalchi F; Salvadori M; Lanciotti E; Institute of Hygiene, University of Florence, Firenze, Italy.
In view of the present world-wide diffusion of HIV, we evaluated the possible presence of persons infected by HIV or suffering from AIDS among the patients and staff of two Dialysis Centers. In the past these centers have been found to be at a high risk for HBV infection. The results of this seroepidemiological study,
Hosp Community Psychiatry. 1988 Jul;39(7):731-9. Unique Identifier : AIDSLINE MED/88297589
Perry SW; Markowitz JC; Consultation-Liaison Service, New York Hospital-Cornell Medical; Center, New York 10021.
Recommendations are presented for counseling individuals who wish to know if they have been infected by the human immunodeficiency virus (HIV). Pretest counseling includes explaining the sensitivity and meaning of HIV antibody tests and the limits of confidentiality, assessing the patient s potential strengths, vulner
Wilton JM; Griffiths GS; Curtis MA; Maiden MF; Gillett IR; Wilson DT; Sterne JA; Johnson NW; Medical Research Council, London Hospital Medical College, UK.
The evidence for systemic predisposition to periodontal diseases is reviewed in relation to cellular and humoral immunity, drug therapy, diet and nutrition and stress. It is concluded that, apart from defects of polymorphonuclear leukocytes (PMN) and Ehlers-Danlos Syndrome, little firm evidence exists for other diseas
Med Hypotheses. 1988 Jul;26(3):207-15. Unique Identifier : AIDSLINE MED/88301938
Goodman S; International Inst. of Symbiotic Studies, Brighton, Sussex, U.K.
Germanium is present in all living plant and animal matter in micro-trace quantities. Its therapeutic attributes include immuno-enhancement, oxygen enrichment, free radical scavenging, analgesia and heavy metal detoxification. Toxicological studies document Germanium s rapid absorption and elimination from the body, a
Fromtling RA; Abruzzo GK; Ruiz A; Department of Basic Microbiology, Merck Institute for Therapeutic; Research, Rahway, NJ 07065-0900.
A strain of Cryptococcus neoformans that was isolated from the cerebrospinal fluid of a human diagnosed as having acquired immunodeficiency syndrome (AIDS), and that produced cutaneous lesions in experimentally infected, normal mice is described. Although no unusual cutaneous manifestations were noted in the patient s
Nature. 1988 Aug 11;334(6182):532-4. Unique Identifier : AIDSLINE MED/88302445
Cohen EA; Terwilliger EF; Sodroski JG; Haseltine WA; Dana-Farber Cancer Institute, Department of Pathology, Harvard; Medical School, Boston, Massachusetts 02115.
Human immunodeficiency virus 1 (HIV-1) is the aetiological agent of AIDS. The virus establishes lytic, latent and non-cytopathic productive infection in cells in culture. The complexity of virus-host cell interaction is reflected in the complex organization of the viral genome. In addition to the genes that encode the
Dromer F; Aucouturier P; Clauvel JP; Saimot G; Yeni P; Laboratoire des Infections Experimentales, Faculte Xavier; Bichat, Paris, France.
Anti-Cryptococcus neoformans capsular polysaccharide (CPS) antibodies were measured by ELISA in patients with AIDS related complex or AIDS without a known history of cryptococcosis and in heterosexual healthy controls. Total and IgG anti-CPS antibody activity was rarely detected in patients, with mean levels lower tha
Wien Med Wochenschr. 1988 Apr 30;138(8):174-80. Unique Identifier : AIDSLINE MED/88306361
Schmidt BL; Hutterer J; Kunz C; Gschnait F; Dermatologischen Abteilung, Krankenhauses der Stadt Wien Lainz.
145.990 sera obtained from AIDS-risks groups, hospitalized patients, blood donors etc. were tested for the presence of antibodies against the AIDS-Virus (HIV:Human Immunodeficiency Virus). All sera were submitted to ELISA screening. Sera with positive and questionable results were submitted to two independent confirma
Clinical symptoms of the central and peripheral nervous system occur in about 40% of patients wit HIV infection. At autopsy, CNS lesions can be demonstrated in even higher percentages. Primary sequelae of HIV infection--either due to direct viral effects or the immunopathologic response of the human host--are acute as
Am J Med. 1988 Feb;84(2):225-32. Unique Identifier : AIDSLINE MED/88307377
Qunibi W; Akhtar M; Sheth K; Ginn HE; Al-Furayh O; DeVol EB; Taher S; Department of Medicine, King Faisal Specialist Hospital and; Research Center, Riyadh, Saudi Arabia.
Between September 1975 and November 1986, 263 renal transplant recipients at the King Faisal Specialist Hospital and Research Center were followed; 82 procedures were done by the authors using live related donors. Among the 263 patients, 14 cases of Kaposi s sarcoma were identified, an incidence of 5.3 percent compare
Am J Med. 1988 Aug 29;85(2A):176-81. Unique Identifier : AIDSLINE MED/88307429
Furman PA; Barry DW; Department of Virology, Burroughs Wellcome Company, Research; Triangle Park, North Carolina 27709.
Zidovudine is a potent in vitro inhibitor of human immunodeficiency virus (HIV) with varying efficacy against other retroviruses. With the exception of Epstein-Barr virus, all non-retroviruses tested so far have been insensitive to inhibition by zidovudine. In vivo, efficacy of zidovudine was demonstrated against Raus
Am J Med. 1988 Aug 29;85(2A):182-5. Unique Identifier : AIDSLINE MED/88307430
Hirsch MS; Infectious Disease Unit, Massachusetts General Hospital, Harvard; Medical School, Boston 02114.
During 1987, a new era in the approach to treatment of severe human immunodeficiency virus (HIV)-I infections was entered. The increased availability of zidovudine and its licensure in many countries have resulted in its widespread use. With these developments have come a multitude of new questions. How long will clin
Am J Med. 1988 Aug 29;85(2A):195-202. Unique Identifier : AIDSLINE MED/88307433
Pizzo PA; Eddy J; Faloon J; Pediatric Branch, National Cancer Institute, Bethesda, Maryland; 20892.
Acquired immune deficiency syndrome (AIDS) in children has until recently been under-reported, since the initial Centers for Disease Control definition of AIDS was restrictive. The case definition has now been revised. Most children with AIDS acquired their infection perinatally and have a parent with established AIDS
Am J Med. 1988 Aug 29;85(2A):208-13. Unique Identifier : AIDSLINE MED/88307436
Richman DD; Andrews J; Division of Infectious Diseases, University of California, San; Diego.
Zidovudine ( AZT , 3 -azido-3 -deoxythymidine) was shown in a controlled trial to decrease the incidence of mortality, reduce the frequency of opportunistic infections, and provide other clinical benefits to patients with acquired immune deficiency synd
Broker M; Jahn G; Kupper HA; Research Laboratories of Behringwerke AG, Marburg, W.-Germany.
Defined cDNA sequences encoding segments of envelope glycoproteins of the human immunodeficiency virus were expressed in E. coli. The recombinant env fusion proteins were tested for immunoreactivity with patient sera by radio immunoprecipitation procedures. The regions of the env proteins, carrying relevant antigenic
Hilfenhaus J; Gregersen JP; Research Laboratories of Behringwerke AG, Marburg, W. Germany.
Human retroviruses causing AIDS (HIV) may occur in human plasma. Since HIV contaminated plasma cannot be completely excluded by testing for anti-HIV, AIDS safety of human plasma products can only be achieved by introducing HIV inactivating and/or eliminating methods into the manufacturing procedure. Here we review a n
Autran B; Mayaud CM; Raphael M; Plata F; Denis M; Bourguin A; Guillon JM; Debre P; Akoun G; Laboratoire d'Immunologie Cellulaire et Tissulaire, Hopital; Pitie-Salpetriere, Paris, France.
A T8 lymphocyte alveolitis occurs in HIV-positive patients, even in the absence of any lung infections or tumors. Using the monoclonal antibody (MAb) D44, the CD8+ T cells can be further subdivided into two functional subsets of cytotoxic T lymphocytes (CTL; CD8+, D44+) and suppressor T cells (CD8+, D44-). A dual fluo
Biberfeld G; Thorstensson R; Bergstrom M; Naucler A; Costa CM; Department of Immunology, National Bacteriological Laboratory,; Stockholm, Sweden.
Enzyme-linked immunosorbent assays (ELISA) were developed for the demonstration of antibodies to HIV-2 using disrupted virions of the SBL-6669 isolate of HIV-2 and the so-called human T-lymphotropic virus type IV (HTLV-IV), recently found to be identical with the simian immunodeficiency virus (SIVmac), as antigens. Th
Carael M; Van de Perre PH; Lepage PH; Allen S; Nsengumuremyi F; Van Goethem C; Ntahorutaba M; Nzaramba D; Clumeck N; Institute for Sociology, Free University of Brussels, Belgium.
From February to June 1986, 150 heterosexual couples with at least one HIV-seropositive member were recruited in the Centre Hospitalier de Kigali , Kigali, Rwanda . Of the 138 HIV-seropositive couples in whom both members were tested, 124 (90%) were sexual unions between two antibo
Byers RH Jr; Morgan WM; Darrow WW; Doll L; Jaffe HW; Rutherford G; Hessol N; O'Malley PM; AIDS Program, Centers for Disease Control, Atlanta, GA 30333.
Between 1978 and 1980 a cohort of approximately 6700 homosexual and bisexual men were recruited from the San Francisco City Clinic to participate in studies of sexually transmitted hepatitis B. Testing frozen blood specimens collected at intervals from these patients provides a means of tracking the spread of the AIDS
Amiel C; Bene MC; May T; Canton P; Faure GC; Laboratoire d'Immunologie, CHU de Nancy, France.
The expression of the adhesion molecule LFA1 was investigated in mononuclear cells from 200 samples of peripheral blood obtained from asymptomatic HIV-infected individuals and AIDS patients. The numbers and percentages of LFAI-positive cells were established by indirect immunofluorescence. A significant decrease in th
Varnier OE; Lillo FB; Schito GC; Lazzarin A; Kanki PJ; Institute of Microbiology, School of Medicine, Genova, Italy.
Since HIV-2 infection has been identified in some European countries, we investigated whether HIV-2 infection is present in groups of Italian subjects at risk for AIDS. Our results clearly indicate that the parallel Western blot assay for HIV-1 and HIV-2 antibodies can detect HIV-2 infection, which is presently not ep
De Cock KM; Colebunders R; Francis H; Nzilambi N; Laga M; Ryder RW; Bondjobo M; McCormick JB; Piot P; Division of Viral Diseases, Center for Infectious Diseases,; Atlanta, GA 30333.
The clinical case definition for AIDS proposed by WHO for use in Africa was evaluated against HIV antibody status in 72 patients in rural Zaire . Twenty-one (29%) of the patients were antibody-positive. For diagnosing anti-HIV seropositivity, the case definition had a sensitivity o
Nine men positive for antibody to human immunodeficiency virus (HIV) who developed peripheral, non-erosive arthritis were followed up. The clinical features were compatible with reactive arthritis but were atypical in several respects: the joint symptoms were generally severe, persistent, and unresponsive to non-stero
Br Med J (Clin Res Ed). 1988 Jun 11;296(6637):1627-8. Unique Identifier : AIDSLINE MED/88281979
Cameron PU; Cobain TJ; Zhang WJ; Kay PH; Dawkins RL; Department of Clinical Immunology, Royal Perth Hospital, Queen; Elizabeth II Medical Centre, Western Australia.
The hypothesis that complement is important in the host response to human immunodeficiency virus (HIV) was tested. Complement C4 and Bf allotypes were determined in 26 patients who fulfilled the diagnostic criteria for persistent generalised lymphadenopathy due to HIV, 72 homosexuals who were negative for antibody to
Klin Wochenschr. 1988 May 16;66(10):437-42. Unique Identifier : AIDSLINE MED/88287304
Flepp M; Tauber MG; Luthy R; Siegenthaler W; Department Medizin, Universitatshospital, Zurich, Schwiez.
We evaluated the response to therapy and outcome in patients with HIV-associated KS. Eighteen of 26 patients with newly diagnosed KS were treated continuously with IFN until progression of the disease occurred. In most patients with progressive disease, chemotherapy, usually with vinca alcaloid derivatives was institu
Med Hypotheses. 1988 May;26(1):85-8. Unique Identifier : AIDSLINE MED/88288096
Tihole F
The enhancement of antimicrobial resistance and immunomodulatory action, and the anabolic effect caused by the consumption of live lactobacteria as a dietary adjunct are proposed by the author as sufficient reasons to test lactobacterial preparations in patients with AIDS. The problem of dosage is discussed and a prac
Tirelli U; Vaccher E; Ambrosini A; Andriani A; Bianco Silvestroni I; Broccia G; Chisesi T; Dessalvi P; Gobbi M; Fassio F; et al; Division of Medical Oncology, Centro di Riferimento Oncologico,; Aviano, Italy.
We report 36 patients with non-Hodgkin s lymphomas (NHL) and 10 patients with Hodgkin s disease (HD), predominantly intravenous drug abusers (IVDA; 35 patients), diagnosed in 16 different Italian centers. The group of NHL has a median age of 26 years (range 16-64): 26 were IVDA, 3 polytransfused, 3 IVDA and homosexual
Br Med J (Clin Res Ed). 1988 Jun 18;296(6638):1717-9. Unique Identifier : AIDSLINE MED/88294543
Stimson GV; Alldritt L; Dolan K; Donoghoe M; Sociology Department, University of London, Goldsmith's College.
In 1987 experimental schemes for distributing injecting equipment to intravenous drug users to help prevent the spread of the human immunodeficiency virus were started by the government. After six months the schemes were found to have been reasonably successful in attracting clients but were less successful in keeping
Hartmann M; Schnurbus R; Henkes H; Kubicki S; Bienzle U; Klinikum Rudolf Virchow, Standort Charlottenburg, der FU Berlin.
The visual evaluation of 370 clinical EEGs of 125 patients in different stages of the HIV-infection as well as 42 HIV-seronegative volunteers of the same high risk population (male homosexuals) proved the increasing appearance of CNS dysfunction with progression of the disease. An especially established hyperventilati
Voth R; Rossol S; Hess G; Laubenstein HP; Meyer zum Buschenfelde KH; Schroder HC; Bachmann M; Reuter P; Muller WE; I. Medizinische Klinik und Poliklinik, Universitat, Mainz, West; Germany.
Avarol is a cytostatic and anti-human immunodeficiency virus (HIV) agent. In this study, the avarol caused induction of gamma-interferon (IFN-gamma) in buffy coat cells (human peripheral blood lymphocytes) is demonstrated by immunological and molecular biological techniques. IFN-gamma production was detected after a 2
Kappes JC; Morrow CD; Lee SW; Jameson BA; Kent SB; Hood LE; Shaw GM; Hahn BH; Department of Medicine, University of Alabama, Birmingham 35294.
Human and simian immunodeficiency-associated retroviruses are extraordinarily complex, containing at least five genes, tat, art, sor, R, and 3 orf, in addition to the structural genes gag, pol, and env. Recently, nucleotide sequence analysis of human immunodeficiency virus type 2 (HIV-2) and simian immunodeficiency v
NIDA Res Monogr. 1988;80:119-36. Unique Identifier : AIDSLINE MED/88302330
Pascal CB; Alcohol, Drug Abuse, and Mental Health Administration, Department; of Health and Human Services, Rockville, MD 20857.
This paper has surveyed the laws restricting the use of hypodermic needles and syringes for injection of illegal drugs. It has reviewed the constitutional basis for these laws and concluded that they are on sound footing. There is a new Federal law regulating needles and syringes in interstate commerce, but it is too
NIDA Res Monogr. 1988;80:176-83. Unique Identifier : AIDSLINE MED/88302334
Battjes RJ; Pickens RW; Division of Clinical Research, National Institute on Drug Abuse,; Rockville, MD 20857.
In summary, the conference focused on one means of HIV transmission among intravenous drug abusers: exposure through the sharing of drug injection equipment. The participants emphasized the urgency of the AIDS epidemic among intravenous drug abusers. A massive effort is needed now to prevent further spread of the dise
NIDA Res Monogr. 1988;80:59-74. Unique Identifier : AIDSLINE MED/88302338
Buning EC; van Brussel GH; van Santen G; Drug Department GG & GD, Amsterdam, The Netherlands.
In summary, it can be stated that Amsterdam has a wide variety of helping modalities. Approximately 70 percent of the city s 7,000 drug addicts are in contact with this helping system. In The Netherlands , no evidence could be found to support the fear that low-threshold methad
NIDA Res Monogr. 1988;80:7-17. Unique Identifier : AIDSLINE MED/88302339
Haverkos HW; Division of Clinical Research, National Institute on Drug Abuse,; Rockville, MD 20857.
AIDS is a serious public health problem for IVDAs in the United States and Europe. Although AIDS and HIV infection are concentrated in New York and New Jersey in the United States, and in Italy and Spain in Europe,
NIDA Res Monogr. 1988;81:237-41. Unique Identifier : AIDSLINE MED/88302365
Kosten T; Gawin F; Schumann B; Substance Abuse Treatment Unit, Connecticut Mental Health Center.
Intravenous cocaine use in methadone patients has become a major problem because of both the complications of cocaine use and the potential spread of AIDS. During an eight week open trial we found that desipramine reduced cocaine craving and use in eight cocaine abusing methadone maintenance patients compared to eight
Public Health Rep. 1988 Jul-Aug;103(4):355-9. Unique Identifier : AIDSLINE MED/88304471
Richwald GA; Wamsley MA; Coulson AH; Morisky DE; School of Public Health, University of California, Los Angeles.
The use of condoms has assumed a central position in the current strategy to prevent sexual transmission of the human immunodeficiency virus. The effectiveness of condoms in disease prophylaxis is dependent, to a degree, on their correct use. Condom manufacturers routinely include information on condom use either prin
Beaudet B; Sachs RN; Fischbein L; Robineau M; Kemeny JL; Amouroux J; Lanfranchi J; Service de medecine interne, cardiologie, Hopital Avicenne,; Bobigny.
A case of acquired immunodeficiency syndrome associated with myocarditis is reported. The myocarditis was peculiar in that it heralded the syndrome and followed a subacute course. It was most probably of infectious origin, although no pathogen has positively been identified; it may have been caused by a
Recent studies reported in the literature have repeatedly pointed out the utility of imidazole derivatives, one of which is bifonazole, in the therapy of seborrheic dermatitis (SD). The cause of this pathological situation is still under discussion but the therapeutic success obtained with antimycotics speaks in favor
Med Hypotheses. 1988 May;26(1):55-8. Unique Identifier : AIDSLINE MED/88288090
Allen AD; Biomedical Sciences Division, Algorithms, Incorporated,; Northridge, California 91325.
A mathematical model of AIDS and its response to treatment with immunostimulation therapy is introduced. It correctly predicted the response of an AIDS patient to hyperimmunization with inactivated polio vaccine for a period of four months, indicating that this benign modality will offset the clinical effects of HIV-1
Friedlander AH; Arthur RJ; Brentwood Division, West Los Angeles Veterans Administration; Medical Center.
Acquired immunodeficiency syndrome (AIDS) was discovered in 1981. It is now estimated that 1.5 million persons have become infected and that, by the year 1991, there will be 270,000 cases of the disease and 179,000 associated deaths. An extraordinary aspect of the AIDS epidemic is the high level of fear manifested by
Science. 1988 Aug 5;241(4866):712-6. Unique Identifier : AIDSLINE MED/88290701
Lifson JD; Hwang KM; Nara PL; Fraser B; Padgett M; Dunlop NM; Eiden LE; Division of Cellular Immunology, Genelabs Incorporated, Redwood; City, CA 94063.
Synthetic peptide segments of the CD4 molecule were tested for their ability to inhibit infection of CD4+ cells by the human immunodeficiency virus (HIV) and to inhibit HIV-induced cell fusion. A peptide mixture composed of CD4(76-94), and synthesis side products, blocked HIV-induced cell fusion at a nominal concentra
Cardin AD; Bowlin TL; Krstenansky JL; Merrell Dow Research Institute, Cincinnati, OH 45215.
Apolipoproteins B and E of the human plasma lipoproteins are known inhibitors of lymphocyte proliferation. In this report, two synthetic peptide amides, apoB3358-3372 and apoE141-155, showed a dose-dependent inhibition of both the murine mixed lymphocyte culture reaction and the anti-T3 induced proliferation of lympho
Cell. 1988 Aug 12;54(4):561-75. Unique Identifier : AIDSLINE MED/88295131
Siliciano RF; Lawton T; Knall C; Karr RW; Berman P; Gregory T; Reinherz EL; Laboratory of Immunobiology Dana-Farber Cancer Institute Harvard; Medical School Boston, Massachusetts 02115.
The primary human T cell response to HIV was analyzed by isolating from seronegative donors T cell clones specific for HIV gp120. T cell epitopes restricted by different MHC elements were identified within gp120, and synthetic peptides were used to address the fundamental problem of how HIV sequence variability affect
Paranoid psychosis developed in two homosexual patients (aged 36 and 37 years) three and four years, respectively, after found to have an HIV infection. There was a marked reduction in the T-helper to T-suppressor-cell proportion (0.4 and 0.2). Neither computed tomography nor magnetic resonance imaging, nor microscopi
Nature. 1988 Aug 11;334(6182):519-22. Unique Identifier : AIDSLINE MED/88302440
Edman JC; Kovacs JA; Masur H; Santi DV; Elwood HJ; Sogin ML; Hormone Research Institute, University of California, San; Francisco 94143-0534.
Pneumocystis carinii pneumonia is the most common opportunistic infection in AIDS, and accounts for significant morbidity and mortality in these and other immunocompromised patients. P. carinii is a eukaryotic microorganism of uncertain taxonomy that can infect numerous mammalian hosts. Developing from a small, unicel
Nelson KE; Clements ML; Miotti P; Cohn S; Polk BF; Johns Hopkins University School of Hygiene and Public Health,; Baltimore, Maryland.
STUDY OBJECTIVE: To ascertain whether subjects infected with human immunodeficiency virus (HIV) generally develop protective hemagglutination inhibition antibody responses to inactivated influenza vaccines. DESIGN: Prospective study of 104 persons before and after immunization. SETTING: Outpatient clinic and hospital
Calman AF; Busch MP; Vyas GN; McHugh TM; Stites DP; Peterlin BM; Howard Hughes Medical Institute, University of California, San; Francisco 94143.
We and others have shown that HIV-1 transcription and replication in vitro are increased by the binding of transcriptional enhancer DNA sequences in the HIV-1 long terminal repeat (LTR) to a cellular protein designated Nuclear Factor-kappa B (NF-kappa B), a trans-acting transcription factor which is present in activat
Wiley CA; Department of Pathology (Neuropathology), University of; California San Diego, LaJolla 92093.
The strong familial association of Alzheimer disease (AD), the difficulty in transmitting the disease to animals, the mapping of the amyloid gene to human chromosome 21, and the non-inflammatory neuropathology have all been considered evidence against a viral etiology for this disease. However, unconventional slow vir
AIDS Res Hum Retroviruses. 1988 Jun;4(3):175-86. Unique Identifier : AIDSLINE MED/88281279
Arya SK; Laboratory of Tumor Cell Biology, National Cancer Institute,; Bethesda, MD 20892.
New West African human immunodeficiency viruses (HIV-2s) and simian immunodeficiency virus (SIV) contain functional transactivator (tat) gene and tat response elements. Their long terminal repeats (LTR) and tat genes are more related among themselves than to HIV-1 LTR and tat gene. The viral gene expression of HIV-2 a
Cacoub P; Deray G; Baumelou A; Le Hoang P; Rozenbaum W; Gentilini M; Soubrie C; Rousselie R; Jacobs C; Department of Nephrology, Hopital Pitie-Salpetriere, Paris,; France.
Foscarnet (FC) is a new antiviral agent which has been recently proposed for the treatment of severe cytomegalovirus ( CMV ) infections in immunocompromised patients. When used intravenously (i.v.), main adverse effects of FC a
Kuhls TL; Nishanian PG; Cherry JD; Shen JP; Neumann CG; Stiehm ER; Ettenger RB; Bwibo NO; Koech D; Department of Pediatrics, UCLA School of Medicine.
Sera of 95 mothers and 129 children from Nairobi, Kenya , collected in 1976, and of 466 adults and 193 children of Embu District, Kenya, collected in 1984 and 1985, were analyzed for the presence of human immunodeficiency virus type 1 (HIV-1) antibodies. Although no HIV-1 seropositiv
In two males with AIDS, aged 26 and 39 years, who had disseminated Kaposi s sarcoma, massive pericardial effusion with tamponade (confirmed by echocardiography) developed in the final stages. Multiple pericardial taps, of up to two litres, of serous fluid yielded no malignant cells or pathogens cytologically or microb
Begovac J; Puntaric V; Borcic D; Barsic B; Zrinscak J; Beus I; Presecki V; University Hospital of Infectious Diseases Dr. Fran Mihaljevic,; Zagreb, Yugoslavia.
We describe a severe multisystem Coxsackie virus type B3 infection in a previously healthy 14-year-old girl who presented with a mononucleosis-like syndrome (MS). Initial observations included a prominent cervical lymphadenopathy, exudative pharyngitis and leucocytosis with atypical lymphocytosis. At the end of the 2n
Samuel KP; Seth A; Zweig M; Showalter SD; Papas TS; Laboratory of Molecular Oncology, NCI-Frederick Cancer Research; Facility, MD 21701.
Nine envelope (Env) polypeptides, encoding different regions of HIV gp120 and gp41 Env proteins, and accounting for approx. 96% of the entire Env precursor glycoprotein complex (gp160) were expressed in Escherichia coli at levels ranging from approx. 2 to 20% of total cellular protein. The recombinant polypeptides wer
J Immunol. 1988 Aug 15;141(4):1131-6. Unique Identifier : AIDSLINE MED/88285718
Mann DL; Read-Connole E; Arthur LO; Robey WG; Wernet P; Schneider EM; Blattner WA; Popovic M; Section of Biochemical Epidemiology, National Cancer Institute,; Bethesda, MD 20892.
The primary interaction of HIV-1 with the target cell involves the viral large envelope protein (gp120) and the cellular CD4 molecule. mAb reacting with portions of CD4 have been shown to block HIV-1 attachment and infection. In one of the early reports describing HIV-1 cell interaction, some mAb reacting with MHC cla
Lanska MJ; Lanska DJ; Schmidley JW; Department of Neurology, University Hospitals of Cleveland, OH; 44106.
We report a case of syphilitic lumbosacral polyradiculopathy in an HIV-positive, 22-year-old bisexual man with a recent history of secondary syphilis treated with intramuscular penicillin. He presented with rapidly progressive pain and weakness, and muscle wasting in the legs. CSF was under increased pressure and show
Kersey JH; Shapiro RS; Filipovich AH; Bone Marrow Transplantation Program, University of Minnesota,; Minneapolis.
Individuals with either primary or secondary immunodeficiencies are at high risk to develop not only infections but also malignancy (especially of the lymphoid system). The major focus of this paper is on malignancies that develop in immunodeficiency syndromes, particularly malignancies in naturally occurring immunode
Miyatake S; Seiki M; Malefijt RD; Heike T; Fujisawa J; Takebe Y; Nishida J; Shlomai J; Yokota T; Yoshida M; et al; Department of Molecular Biology, DNAX Research Institute of; Molecular and Cellular Biology, Palo Alto, CA 94304-1104.
The effects of p40x, a product of an human T cell leukemia virus type I, on the activation of lymphokine genes were examined. The mouse GM-CSF and IL-3 genes were activated by cotransfection with a pX containing plasmid both in Jurkat and CV1 cells. Mouse GM-CSF gene was also activated by phytohaemagglutinin A (PHA)/p
Proc Natl Acad Sci U S A. 1988 Aug;85(15):5693-7. Unique Identifier : AIDSLINE MED/88289783
de Bustros A; Nelkin BD; Silverman A; Ehrlich G; Poiesz B; Baylin SB; Oncology Center, School of Medicine, Johns Hopkins University,; Baltimore, MD 21215.
Inactivation of normally expressed genes may play a role in the formation and/or progression of human cancers. Methylation of cytosine in DNA could potentially participate in such alterations of gene expression. Abnormalities in DNA methylation are a consistent feature of human neoplasms, and we now show that these in
Sullivan CJ; Jordan MC; University of Minnesota Medical School, Minneapolis 55455.
The diagnosis of viral pneumonia has changed during the past decade from a purely clinical diagnosis to one that is both clinical and laboratory in nature. Viral pneumonias can be divided into two clinical groups: the so-called atypical pneumonias in otherwise normal hosts, and viral pneumonitis in the immunocompromis
Flaegstad T; Permin H; Husebekk A; Husby G; Traavik T; Department of Microbiology, University of Tromso, Norway.
Antibodies to the human papovavirus BK (BKV) were determined in a group of 25 homo- and bisexual males with AIDS, 24 men with AIDS-related complex (ARC) and 18 healthy male homosexual controls from Copenhagen. The AIDS patients had a significantly lower prevalence and level of anti-BKV antibodies tested by IgG-ELISA,
Friedman H; Klein T; Specter S; Pross S; Newton C; Blanchard DK; Widen R; Department of Medical Microbiology and Immunology, University of; South Florida, College of Medicine, Tampa 33612.
It is widely recognized that various microorganisms including viruses have immunomodulatory effects and, under appropriate circumstances, may markedly suppress the immune response mechanisms. Cannabinoids present in marijuana also have immunomodulatory effects. In the present studies THC as well as its metabolic produ
Pert CB; Ruff MR; Ruscetti F; Farrar WL; Hill JM; Section on Brain Biochemistry, National Institute of Mental; Health, Alcohol, Drug Abuse, Bethesda, Maryland 20892.
Chang RS; Yeung HW; Department of Microbiology, Chinese University of Hong Kong.
Twenty-seven medicinal herbs reputed in ancient Chinese folklore to have anti-infective properties were extracted by boiling under reflux. The extracts were tested for inhibitory activity against the human immunodeficiency virus in the H9 cell line at concentrations nontoxic to growth of the H9 cells. Using a signific
Gordon LM; Jensen FC; Curtain CC; Mobley PW; Aloia RC; Rees-Stealy Research Foundation, San Diego, CA 92101.
The presence of thermodependent lipid domains in the envelope of the human immunodeficiency virus (HIV) was studied. HIV was propagated in Hut-78 cells and purified by differential-gradient centrifugation. Since the virus was highly infectious in cell culture and Western blots of detergent-inactivated HIV showed envel
Marolleau JP; Henni T; Gaulard P; Le Couedic JP; Gourdin MF; Divine M; Katz A; Tulliez M; Goossens M; Reyes F; et al; Institut National de la Sante et de la Recherche Medicale; (INSERM) U.91, Hopital Henri Mondor, Creteil, France.
The authors describe a patient who presented an association of hairy cell leukemia (HCL) and large granular lymphocyte (LGL) leukemia. An eventual relationship between these two rare entities is analyzed. Hairy cells (HCs) were present in the blood, bone marrow, and spleen. An excess of LGLs was found only in the bloo
Subar M; Neri A; Inghirami G; Knowles DM; Dalla-Favera R; Department of Pathology, Kaplan Cancer Center, New York; University School of Medicine, NY 10016.
Sixteen cases of histologic intermediate-grade and high-grade AIDS-associated non-Hodgkin s lymphoma (NHL) were studied for the presence and patterns of c-myc gene and bcl-2 locus rearrangements. The presence of Epstein-Barr virus (EBV) sequences and proteins and HTLV-I sequences w
Rudlinger R; Grob R; Buchmann P; Christen D; Steiner R; Department of Dermatology, University Hospital, Zurich,; Switzerland.
Anogenital warts of the condyloma acuminatum type seem to occur quite often during HIV infection. These warts--according to our study--are not commonly caused by malignancy-associated human papilloma virus types, but by types 6 and 11 as seen in the nonimmune-compromised population. Widespread condylomata acuminata ma
Int J Cancer. 1988 Aug 15;42(2):221-4. Unique Identifier : AIDSLINE MED/88297885
Imamura J; Tsujimoto A; Ohta Y; Hirose S; Shimotohno K; Miwa M; Miyoshi I; Department of Internal Medicine, Kochi Medical School, Japan.
The structure of the integrated provirus in cell lines established from the cerebrospinal fluid (CSF) of patients with human T-cell leukemia virus type-1 (HTLV-1)-associated myelopathy (HAM) was analyzed. The digestion patterns with 3 restriction endonucleases, Sac I, Eco RI and PstI, of the proviruses integrated in T
von der Helm D; von der Helm K; Burg G; Braun-Falco O; Deinhardt F; Dermatologische Klinik und Poliklinik, Universitat Munchen.
The possibility that lymphoproliferative diseases may have a viral etiology has been discussed for many years. The first piece of evidence - in combination with convincing epidemiological data was the detection of a virus of the HTLV group (HTLV I, ATLV) in patients with adult T-cell leukemia in
Geyer H; Holschbach C; Hunsmann G; Schneider J; Biochemisches Institut der Justus-Liebig-Universitat Giessen,; Federal Republic of Germany.
Human T-cells (H9), persistently infected with the HTLV-III strain of human immunodeficiency virus, were metabolically labeled with D-[2-3H]mannose or D-[6-3H]glucosamine. The viral envelope glycoprotein, gp120, was isolated either from cell lysates or from cell-free culture supernatant. After proteolytic digestion, t
Effective treatment of infections with human immunodeficiency virus type 1 (HIV-1) may require a combination of antiviral drugs that act by different mechanisms. We report that the combination of 2 ,3 -dideoxycytidine (ddCyd) and recombinant interferon-alpha-A (rIFN-alpha-A) acts synergistically against HIV-1 replicat
Cunningham AL; Grohman GS; Harkness J; Law C; Marriott D; Tindall B; Cooper DA; Department of Virology, Westmead Hospital, Sydney, New South; Wales, Australia.
Gastrointestinal viruses, predominantly rotaviruses and adenoviruses, were detected by enzyme-linked immunosorbent assay, electron microscopy, or cell culture in greater than 50% of two groups of homosexual men with symptomatic human immunodeficiency virus (HIV) infection, who did (54%) or did not (50%) have diarrhea.
Drew WL; Department of Clinical Microbiology, Biskind Pathology Research; Laboratory, Mount Zion Hospital and Medical Center, San; Francisco, California 94115.
Ouattara SA; Gody M; Rioche M; Sangare A; Meite M; Akran V; Aron Y; Sanogo I; Ouattara D; Saraka K; et al; Institut Pasteur de Cote-D'Ivoire, Abidjan, Ivory Coast.
Sera from 500 blood donors, 67 multiply-transfused children with sickle-cell anaemia and 320 healthy children who had not been transfused were tested for HIV1 and HIV2 antibodies. Amongst blood donors, 49 (9.8%) exhibited antibodies to retroviruses: 12 (2.4%) to HIV1, 17 (3.4%) to HIV2 and 20 (4%) to both HIV1 and HIV
Berman PW; Nunes WM; Haffar OK; Department of Molecular Biology, Genetech, Inc., South San; Francisco, California 94080.
The gene encoding the 856-amino-acid envelope glycoprotein, gp160, of human immunodeficiency virus type 1 was mutagenized and transfected into Chinese hamster ovary cells. Continuous cell lines that constitutively produced gp160 variants were isolated and used to study the biosynthesis and orientation of gp160 in cell
Monroe JE; Calender A; Mulder C; Department of Pharmacology, University of Massachusetts Medical; School, Worcester 01655.
Human immunodeficiency virus type 1 (HIV-1) can infect CD4+ lymphocytes, monocytes-macrophages, and various other cell lines, including B-cell lines. To study the parameters of B-cell infections, we examined the susceptibility of 24 B-lymphoid cell lines to both HIV-1 and HIV-2 infections. These cell lines included a
Life Sci. 1988;43(6):v-xi. Unique Identifier : AIDSLINE MED/88301771
Watson RR; Prabhala RH; Darban HR; Yahya MD; Smith TL; Department of Family and Community Medicine, University of; Arizona, Tucson 85724.
Infection by LP-BM5 murine leukemia virus (MuLV) suppressed significantly the percentage of peripheral blood cells showing surface markers for macrophages, lymphocytes and activated lymphoid cells. Chronic administration of a 7% (36% calories) ethanol diet or injection of 1.9 mg/mouse/day of morphine for a 7 day perio
Life Sci. 1988;43(6):xiii-xviii. Unique Identifier : AIDSLINE MED/88301772
Watson RR; Yahya MD; Darban HR; Prabhala RH; Department of Family and Community Medicine, University of; Arizona, College of Medicine, Tucson 85724.
Infection by LP-BM5 murine leukemia virus (MuLV) produces an AIDS-like condition in mice. The viral infection suppressed the percentage of peripheral blood cells showing surface markers for macrophages, activated macrophages, T lymphocytes and activated lymphoid cells. High dietary vitamin A (retinyl palmitate) caused
Jakobovits A; Smith DH; Jakobovits EB; Capon DJ; Department of Molecular Biology, Genentech, Inc., South San; Francisco, California 94080.
An important point of regulation in the reproductive growth and latency of the human and simian immunodeficiency viruses (HIV and SIV, respectively) is provided by virally encoded trans-activators (tat), proteins capable of dramatically increasing viral gene expression. The mechanism of this autostimulatory pathway ha
AIDS is a disorder characterized by a slow progressive impairment of immune function and by infection of human immunodeficiency viruses (HIV-1, HIV-2). Our knowledge of how these viruses cause disease in man, or how the related lentiviruses (visna and equine infectious anaemia virus) cause disease in animals, is still
Nature. 1988 Aug 11;334(6182):530-2. Unique Identifier : AIDSLINE MED/88302444
Lanzavecchia A; Roosnek E; Gregory T; Berman P; Abrignani S; Basel Institute for Immunology, Switzerland.
To trigger class II-restricted T cells, antigen presenting cells have to capture antigens, process them and display their fragments in association with class II molecules. In most species, activated T cells express class II molecules; however, no evidence has been found that these cells can present soluble antigens. T
Public Health Rep. 1988 Jul-Aug;103(4):366-75. Unique Identifier : AIDSLINE MED/88304473
Remington PL; Smith MY; Williamson DF; Anda RF; Gentry EM; Hogelin GC; Division of Nutrition, Centers for Disease Control (CDC),; Atlanta, GA 30333.
Since 1981, the Centers for Disease Control has collaborated with State health departments and the District of Columbia to conduct random digit-dialed telephone surveys of adults concerning their health practices and behaviors. This State-based surveillance system, which yields data needed in planning, initiating, and
Via CS; Shanley JD; Weatherly BR; Lang P; Shearer GM; Immunology Branch, National Cancer Institute, Bethesda, Maryland; 20892.
Acute murine cytomegalovirus (MCMV) infection enhances the ability of parental spleen cells to induce graft-vs.-host immunodeficiency (GVHID) in F1 hybrid mice when the two processes occur simultaneously in the recipient. The present study assessed GVHID as the ability of spleen ce
Ball JM; Payne SL; Issel CJ; Montelaro RC; Department of Biochemistry, Louisiana State University, Baton; Rogue.
Nucleotide sequence analyses of two different proviral clones of equine infectious anemia virus (EIAV), designated lambda 12 (K. Rushlow et al., 1986, Virology 155, 309-321) and 1369 (T. Kawakami et al., 1987, Virology 158, 300-312), indicate significant differences in the organization of two critical regions of the v
Ramsey RG; Geremia GK; Department of Diagnostic Radiology and Nuclear Medicine,; Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL 60612.
AIDS is now a common disease, seen daily in large metropolitan medical centers. Neuroimaging techniques such as CT and MR are critical to the detection and diagnosis of CNS complications. Intracerebral infections are common. These infections frequently are caused by opportunistic organisms; less commonly, they are bac
Am J Med. 1988 Feb;84(2):218-24. Unique Identifier : AIDSLINE MED/88307376
Jacobson MA; Cello JP; Sande MA; Department of Medicine, University of California, San Francisco.
A cholestatic syndrome caused by papillary stenosis and sclerosing cholangitis (PS/SC) has been recently described as a complication of the acquired immunodeficiency syndrome (AIDS). Cytomegalovirus has been implicated as an etiologic factor in this syndrome. Consecutive cases of disseminated
Am J Med. 1988 Aug 29;85(2A):107-15. Unique Identifier : AIDSLINE MED/88307415
Andersson J; Ernberg I; Department of Infectious Diseases, Danderyd Hospital, Stockholm,; Sweden.
Both oral and intravenous acyclovir administration for seven days in the early stages of infectious mononucleosis caused an inhibition of oropharyngeal Epstein-Barr virus (EBV) replication. Minimal effect on clinical symptoms was observed. Development of normal cellular and humoral EBV-specific immunity was seen in al
D'Onofrio C; Perno CF; Mazzetti P; Graziani G; Calio' R; Bonmassar E; Department of Experimental Medicine and Biochemical Sciences, II; University of Rome, Italy.
Natural human interferon beta (beta-IFN) was tested during the early phase of in vitro infection with HTLV-I virus of human cord blood mononuclear cells (CBL), to evaluate whether its antiviral and immunomodulating effects might prevent spreading of infection in the host. beta-IFN was found to reduce HTLV-I transmissi
Cancer. 1988 Aug 15;62(4):702-4. Unique Identifier : AIDSLINE MED/88282292
Kuo TT; Sato H; Dunn P; Shih LY; Eimoto T; Kikuchi M; Maeda Y; Department of Pathology, Chang Gung Medical College, Taipei,; Taiwan, Republic of China.
Human T-lymphotropic virus-I (HTLV-I) proviral DNA was demonstrated in the leukemic cells of two newly identified cases of adult T-cell leukemia/lymphoma (ATL) in Taiwan by the Southern blot hybridization method. Therefore, the ATL
Ahmed R; Hashiba K; Third Department of Internal Medicine, Nagasaki University School; of Medicine, Japan.
Reliability of corrected QT intervals (QoTc, QaTc, and QeTc) as indicators of clinical hypercalcemia was assessed in 14 hypercalcemic patients. Hypercalcemia was severe to extreme (serum calcium 14.9 to 22.8 mg/dl) in 11, moderate (13.4 mg/dl) in 1, and mild (12.2 and 11.8 mg/dl) in 2 patients. QT intervals during hyp
J Immunol. 1988 Aug 1;141(3):984-8. Unique Identifier : AIDSLINE MED/88285705
Vidal C; Matsushita S; Colamonici OR; Trepel JB; Mitsuya H; Neckers LM; Laboratory of Pathology, National Cancer Institute, Bethesda, MD; 20892.
Human T-lymphotropic virus I (HTLV-I) is an etiologic agent in adult T cell leukemia. In an effort to understand the relationship between HTLV-I infection and malignant transformation, we have examined transferrin receptor expression in HTLV-I-infected cells. Transferrin receptor expression in normal T cells is tightl
J Immunol. 1988 Aug 15;141(4):1231-5. Unique Identifier : AIDSLINE MED/88285735
Goebels N; Waase I; Pfizenmaier K; Kronke M; Klinische Arbeitsgruppe, Max-Planck-Gesellschaft, Gottingen,; Federal Republic of Germany.
In situ hybridization studies were performed with 35S-labeled anti-sense RNA probes to study IL-2 mRNA expression in three human T lymphotropic virus I-infected T cell lines at the single cell level. In HuT 102, MT-2, and MT-4 cells, IL-2 mRNA-expressing cells were ide
J Immunol. 1988 Aug 15;141(4):1398-403. Unique Identifier : AIDSLINE MED/88285760
Bhattacharya-Chatterjee M; Chatterjee SK; Vasile S; Seon BK; Kohler H; Department of Gynecologic Oncology, Roswell Park Memorial; Institute, Buffalo, NY 14263.
Previously, we had generated anti-Id mAb (Ab2) binding to a hybridoma SN2 (Ab1), which recognizes a glycoprotein, gp37, expressed by human leukemic T cells. To characterize these anti-idiotopes further, they were used to immunize mice and rabbits. Several murine anti-anti-Idiotype mAb (Ab3), mostly of IgM-k isotype, w
Horowitz MS; Rooks C; Horowitz B; Hilgartner MW; Blood Derivatives Program, New York Blood Center, NY.
The safety of an antihaemophilic factor concentrate treated with the organic solvent tri-(n-butyl)phosphate and sodium cholate (factor VIII-SD) was assessed for transmission of non-A, non-B (NANB) hepatitis and human immunodeficiency virus (HIV). Patients enrolled in the study had no previous exposure to blood product
Lancet. 1988 Aug 13;2(8607):379-82. Unique Identifier : AIDSLINE MED/88287773
Fehrs LJ; Fleming D; Foster LR; McAlister RO; Fox V; Modesitt S; Conrad R; Division of Field Services, Oregon State Health Division, Centers; for Disease Control, Atlanta, Georgia.
Before December, 1986, all public human immunodeficiency virus (HIV) testing in Oregon was done confidentially (using names). In December, clients were offered the option of either anonymous or confidential services. As judged by questionnaire responses, the availability of anonymity increased overall demand for testi
Itoyama Y; Minato S; Kira J; Goto I; Sato H; Okochi K; Yamamoto N; Department of Neurology, Kyushu University, Fukuoka, Japan.
We found unstimulated (spontaneous) peripheral blood lymphocyte (PBL) proliferation significantly increased in 14 patients with human T-lymphotropic virus (HTLV)-I-associated myelopathy (HAM) compared with findings in HTLV-I seropositive non-HAM carriers (N = 8) or HTLV-I seronegative controls (N = 16). The proliferat
Linette GP; Hartzman RJ; Ledbetter JA; June CH; Department of Microbiology, Georgetown University School of; Medicine, Washington, DC 20007.
The binding of antigen or monoclonal antibody to the T cell receptor for antigen or the closely associated CD3 complex causes increases in the concentration of intracellular ionized calcium and subsequent cell proliferation. By measuring second messenger production in primary cultures of human immunodeficiency virus (
Ohtsuki Y; Miyoshi I; Oka T; Hayashi K; Takahashi K; Furihata M; Iwata J; Takeuchi T; Sonobe H; Department of Pathology, Kochi Medical School, Japan.
Fine structural and immunocytochemical characterization of rabbit lymphoid cell lines transformed by human T-lymphotropic virus type I (HTLV-I) was carried out. All nine cell lines tested were reactive with anti-HTLV-I-positive human, monkey, and rabbit sera and monoclonal antibody to HTLV-Ip 19, but not with anti-HTL
Kaneko Y; Maseki N; Homma C; Sakurai M; Mizutani S; Takeda T; Shikano T; Fujimoto T; Yaoi K; Shimokawa T; Department of Laboratory Medicine, Saitama Cancer Center, Japan.
In a chromosome study in childhood T-cell leukemia/lymphoma, we found t(7;11)(q35;p13) in 2 patients, t(7;14) (q35;q11) in one patient, and t(7;14)(p15;q32) in 1 patient. Southern blotting and in situ chromosomal hybridization studies in one patient with the t(7;11) demonstrated that both alleles of the T-cell antigen
Lepers JP; Billon C; Pesce JL; Rollin PE; De Saint-Martin J; Laboratoire de Biologie medicale, Hopital National, Nouakchott.
A serological serosurvey was made in different ethnic groups of Mauritania in 1985. A very high prevalence of hepatitis B markers was found with more than 20% of HBs antigen carriers. Treponema specific antibodies in low-age classes observed is a reflect of endemic syphilis. Th
One hundred consecutive patients with serum antibodies against HIV 1 were evaluated for the prevalence and the type of liver injury. According to the CDC classification, 16 patients belonged to group II (asymptomatic patients), 47 to group III (persistent generalized lymphadenopathy) and 37 to group IV (11 constitutio
Butler JJ; Osborne BM; Department of Pathology, University of Texas M.D. Anderson; Hospital and Tumor Institute, Houston 77030.
The histologic findings in lymph nodes were used to identify eight patients, who are not in a high-risk group, with human immunodeficiency virus (HIV) infection. In order to determine the specificity of these findings, the histologic and clinical findings in these patients were compared with the histologic and clinica
Akizuki S; Setoguchi M; Nakazato O; Yoshida S; Higuchi Y; Yamamoto S; Okajima T; Department of Pathology, Medical College of Oita, Japan.
This report describes the first autopsy case of human T-lymphotropic virus type I (HTLV-I)-associated myelopathy (HAM). The disease mainly affected the spinal cord, particularly the lateral and anterior columns, where loss of myelin and axon was observed. The changes were bilateral and occurred mainly along the tract.
Motoi T; Uchiyama T; Uchino H; Ueda R; Araki K; First Division of Internal Medicine, Faculty of Medicine, Kyoto; University.
Using an enzyme-linked immunosorbent assay (ELISA) technique, we measured the soluble interleukin 2 receptor (s-IL-2R) levels in the sera of patients with adult T-cell leukemia (ATL) in Japan . The s-IL-2R levels in the sera of the ATL patients were markedly higher (range 540-310, 40
Lancet. 1988 Aug 20;2(8608):418-21. Unique Identifier : AIDSLINE MED/88301637
Loche M; Mach B; Department of Microbiology, University of Geneva Medical School,; Switzerland.
There is a need for direct detection of the virus in people infected with human immunodeficiency virus (HIV), independently of a serological response. In this study, after enzymic amplification of a specific segment of the HIV genome, a simple slot-blot hybridisation procedure allowed unequivocal identification of HIV
Ohba T; Matsuo I; Katabuchi H; Nishimura H; Fujisaki S; Okamura H; Department of Obstetrics and Gynecology, Kumamoto University; Medical School, Japan.
Adult T-cell leukemia/lymphoma, a lymphocytic leukemia caused by human T-cell lymphoma virus-I (HTLV-I), is prevalent in southwestern Japan . A Japanese woman with adult T-cell leukemia/lymphoma in the third trimester of pregnancy was delivered of an infant by cesarean section. She d
Goudsmit J; Boucher CA; Meloen RH; Epstein LG; Smit L; van der Hoek L; Bakker M; Human Retrovirus Laboratory, University of Amsterdam, The; Netherlands.
PEPSCAN analysis, performed using 536 overlapping nonapeptides derived from the HTLV-III B nucleotide sequence of the region encoding the external envelope protein of 120 kDa (gp120), identified in the V3 region of gp120 a major binding site for antibodies of HIV-1-infected humans. The minimal amino acid sequence of t
Bahraoui E; Clerget-Raslain B; Chapuis F; Olivier R; Parravicini C; Yagello M; Montagnier L; Gluckman JC; Unite d'Oncologie Virale, Institut Pasteur, Paris, France.
We have investigated the possible involvement in the interaction between HIV gp110 and its CD4 receptor of epitopes different from the currently known binding site(s) of the molecule. Four monoclonal antibodies (MAbs) to gp110 were used (Genetic Systems Corporation, Seattle, Washington, USA): one (110-1) recognized a
Parravicini CL; Klatzmann D; Jaffray P; Costanzi G; Gluckman JC; 5th Chair of Pathological Anatomy and Histology, University of; Milano, Hospital L. Sacco, Italy.
The immunohistochemical reactivity of four monoclonal antibodies (MAbs): CVK, 49-5, 49-6 and 63-FH2, raised against the p18 protein of HIV-1 was assessed in tissues obtained from HIV-infected and uninfected individuals. As already reported, all the MAbs specifically labelled follicular dendritic cells (FDC) in lymph n
AIDS Res Hum Retroviruses. 1988 Jun;4(3):187-97. Unique Identifier : AIDSLINE MED/88281280
Skinner MA; Ting R; Langlois AJ; Weinhold KJ; Lyerly HK; Javaherian K; Matthews TJ; Department of Surgery, Duke University Medical Center, Durham,; NC.
We have studied the biologic and physical properties of a monoclonal antibody that binds to gp120, the exterior envelope glycoprotein of the human immunodeficiency virus (HIV) strain HTLV-IIIB. Designated 9284, the antibody possesses viral neutralizing activity and inhibits syncytium formation by infected cells. The a
Windheuser MG; Wood C; Department of Microbiology, University of Kansas, Lawrence 66045.
We have identified several immunoreactive epitopes on the human immunodeficiency virus (HIV) type 1 transmembrane envelope protein by synthesizing various regions of the protein as fusions to the trpE gene in Escherichia coli. Ten fusion clones which expressed overlapping peptides were found to contain epitopes reacti
Lee YS; Lindsley F. Kimball Research Institute, New York Blood Center,; New York 10021.
HIV antigen capture assay (ELISA) and reverse transcriptase assay were compared for the detection of HIV. Purified virus and the supernatant of infected cells were used for this study. Antigen capture assay was found to be at least one hundred times more sensitive than the RT assay, and for a large number of samples e
Musil SY; Olson CR; Department of Psychology, Princeton University, New Jersey 08544.
The aim of the experiments reported here was to identify cortical and subcortical forebrain structures from which anterior cingulate cortex (CGa) receives input in the cat. Deposits of retrograde tracers were placed at nine sites spanning the anterior cingulate area and patterns of retrograde transport were analyzed.
Ziegler JL; School of Medicine, University of California, San Francisco.
Kaposi s sarcoma presents the oncologist with a myriad of unanswered questions. What accounts for the genesis, distribution, and natural history of this tumor? How could a tumor with such a singular histologic appearance occur in such diverse clinical circumstances? What accounts for the unusual geographic, ethnic, an
Witte MH; Witte CL; Department of Surgery, University of Arizona College of Medicine,; Tucson.
An hypothesis is presented to explain the link between acquired immunodeficiency syndrome (AIDS) and Kaposi s sarcoma (KS). According to this hypothesis, AIDS involves all four components of the integrated lymphatic system--lymphatics, lymph nodes, lymphocytes, and lymph--and thereby resembles various congenital and a
Albano EA; Pizzo PA; Department of Hematology-Oncology, Children's Hospital National; Medical Center, Washington, DC.
The immunocompromised host was first defined around the host abnormalities and consequent infections that were associated with congenitally acquired deficiencies. Although the impact of the deficiency on the affected child was considerable, the numbers of such children remained small. With the advent of immunosuppress
Connors JM; Klimo P; Division of Medical Oncology, Cancer Control Agency of British; Columbia, Vancouver, Canada.
Between 1981 and 1986, we treated 179 newly diagnosed patients with advanced-stage malignant lymphoma or related conditions with methotrexate, doxorubicin, cyclophosphamide, vincristine, prednisone, bleomycin (MACOP-B). Experience with 12 different histologic subtypes indicates that MACOP-B is acceptably tolerated and
Ann Trop Paediatr. 1988 Mar;8(1):1-17. Unique Identifier : AIDSLINE MED/88292908
Blokzijl ML; Department of Tropical Paediatrics, School of Tropical Medicine,; Liverpool, U.K.
Acquired immunodeficiency syndrome is associated with considerable morbidity in infants and children. It is caused by human immunodeficiency virus (HIV) which can be transmitted vertically from mother to infant early in pregnancy. Transmission might also occur via breast milk. Although the exact transmission rate of H
Grieco MH; Lange M; Buimovici-Klein E; Reddy MM; Englard A; McKinley GF; Ong K; Metroka C; Division of Allergy, Clinical Immunology and Infectious Diseases,; St. Luke's/Roosevelt Hospital Center, New York, New York 10019.
AL-721 is a lipid compound composed of neutral lipids, phosphatidylcholine and phosphatidylethanolamine in a 7:2:1 ratio. The objective of this open study was to evaluate the effects of AL-721 in vivo in an 8-week open trial in which 10 g twice daily was administered on a low fat diet to eight HIV-infected subjects wi
Muller WE; Sarin PS; Sun D; Rossol S; Voth R; Rottmann M; Hess G; Meyer zum Buschenfelde KH; Schroder HC; Institut fur Physiologische Chemie, Abt. Angewandte; Molekularbiologie, Universitat, Mainz, F.R.G.
The chemically modified DNA, apurinic acid (APA), is cytotoxic for human lymphocytes at concentrations above 100 micrograms/ml. At low concentrations (0.05-1 micrograms/ml) APA acts as an inducer interferon gamma (IFN-gamma) in lymphocytes in vitro; the maximum interferon titer of 50 units/ml was reached at 0.4 microg
Vilalta-Castel E; Valdes-Sanchez MD; Guerra-Vales JM; Teno-Esteban C; Garzon A; Lopez JI; Ricard MP; Abarca M; Garcia-Diaz JD; Internal Medicine Service, Hospital Primero de Octubre, Madrid,; Spain.
Granulomas in bone marrow are an infrequent finding related to diverse disease. We reviewed 8057 bone marrow studies made over a period of 10.5 years, confirming the presence of granulomas in 40 patients. Global incidence was 0.50% and annual incidence 3.80 cases/yr. Because of the non-specificity of the morphological
Gauger J; Dermatologische Klinik und Poliklinik, Technischen Universitat; Munchen.
Genetic information on the AIDS virus, which belongs to the family of retroviruses, is encoded in a single-strand RNA. After infection of the target cell, its genomic RNA is transcribed into DNA by the reverse transcriptase. Subsequently, the DNA can be integrated into the host genome. This viral genome encodes the en
Niedrig M; Rabanus JP; L'Age Stehr J; Gelderblom HR; Pauli G; Robert Koch-Institut des Bundesgesundheitsamtes, Berlin, F.R.G.
Monoclonal antibodies (MAbs) were raised against gag proteins of human immunodeficiency virus type 1 (HIV-1), strain HTLV-IIIB. One of 29 antibodies was specific for p17 of HIV-1. Twenty of 28 MAbs reactive with the major core protein p24 of HIV-1 showed cross-reactivity with HIV-2, and five of these also detected the
Newland JR; Lynch DP; Ordonez NG; Department of Pathology and Radiology, University of Texas Health; Science Center, Houston.
Oral mucosal lesions of Kaposi s sarcoma are a common finding in patients with acquired immunodeficiency syndrome (AIDS). The histologic features of Kaposi s sarcoma vary, depending on the clinical stage of the lesion. Endothelium-lined vessels are the principal feature of early, macular lesions, while spindle cells d
Barton EN; Roberts L; Ince WE; Patrick AL; Suite M; Basdayemaharaj K; Jankey N; Cleghorn F; Bartholomew C; Department of Medicine, University of the West Indies, General; Hospital, Port of Spain, Trinidad.
Three cases are reported of patients with the Acquired Immune Deficiency Syndrome (AIDS) and cutaneous histoplasmosis. Their initial presentation was that of a generalised maculopapular rash. Two patients were bisexual males and the third was an unmarried female. The range of opportunistic infections seen in AIDS pati
Kuchino Y; Nishimura S; Schroder HC; Rottmann M; Muller WE; Biophysics Division, National Cancer Research Institute, Tokyo,; Japan.
Avarol is a sesquiterpenoid hydroquinone, which displays no inhibitory potencies on mammalian DNA polymerases alpha, beta, and gamma, on mammalian RNA polymerases I, II, and III, or on reverse transcriptases from Moloney murine leukemia virus (Mo-MuLV) and from HIV. For a further elucidation of the antiviral effect of
Am J Med. 1988 Aug 29;85(2A):165-72. Unique Identifier : AIDSLINE MED/88307427
Clumeck N; Hermans P; Department of Internal Medicine, Saint-Pierre University; Hospital, Brussels, Belgium.
Although the management of patients with human immunodeficiency virus infections has focused on the treatment of opportunistic infections, or acquired immune deficiency syndrome (AIDS)-related cancers in end stages of the disease, therapies now aim at preventing the natural progression of the underlying disease. In ad
Am J Med. 1988 Aug 29;85(2A):173-5. Unique Identifier : AIDSLINE MED/88307428
Larder BA; Purifoy DJ; Powell KL; Bradley C; Kemp S; Tisdale M; Ertl P; Darby GK; Stammers D; Wellcome Research Laboratories, Langley Court, Beckenham, Kent,; United Kingdom.
The clinical success of zidovudine has established the human immunodeficiency virus (HIV) reverse transcriptase (RT) as a valid target for the design of drugs to treat acquired immunodeficiency syndrome. In order to facilitate structural studies of this enzyme, expression systems in Escherichia coli, which allow the p
Biochem Biophys Res Commun. 1988 Aug 15;154(3):1182-8. Unique Identifier : AIDSLINE MED/88309101
Motokura T; Fukumoto S; Takahashi S; Watanabe T; Matsumoto T; Igarashi T; Ogata E; Fourth Department of Internal Medicine, University of Tokyo; School of Medicine, Japan.
We analyzed human T cell lymphotrophic virus type I (HTLV-I)-infected T cells for the presence of mRNA coding for parathyroid hormone-related protein (PTHrP) by Northern blotting using synthetic DNA probes. We report here that PTHrP mRNAs were detected in a HTLV-I-infected T cell line, MT-2, but not in uninfected T ce
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