Severe gastrointestinal involvement in children with the acquired immunodeficiency syndrome. NLM AIDSLINE Important note: Information in this article was accurate in 1988. The state of the art may have changed since the publication date.

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Severe gastrointestinal involvement in children with the acquired immunodeficiency syndrome.

J Pediatr Gastroenterol Nutr. 1987 Jul-Aug;6(4):517-24. Unique Identifier : AIDSLINE MED/88118057
McLoughlin LC; Nord KS; Joshi VV; Oleske JM; Connor EM; Department of Pediatrics, Children's Hospital of New Jersey,; UMDNJ-New Jersey Medical School, Newark 07107.

Abstract: Five children with the acquired immunodeficiency syndrome (AIDS) and unusual gastrointestinal disease are described. Two children presented with malnutrition, abdominal distention, and diarrhea. One was found to have moderately severe villus atrophy on jejunal biopsy and was initially thought to have celiac disease. Jejunal biopsy from the second child revealed infiltration of the mucosa with acid-fast bacilli-laden macrophages. A third child suffered recurrent abdominal pain, progressive weight loss, diarrhea, and severe gastrointestinal hemorrhage secondary to infection with cytomegalovirus. Pseudomembranous necrotizing jejunitis associated with overgrowth of Klebsiella pneumoniae in the duodenal fluid occurred in one patient. The fifth child presented in the newborn period with Serratia marcescens cholecystitis. Gastrointestinal disease in children with AIDS may be due to idiopathic villus atrophy and bacterial or opportunistic infection.
Keywords: Acquired Immunodeficiency Syndrome/*COMPLICATIONS Acute Disease Atrophy Bacterial Infections/ETIOLOGY Case Report Child Child, Preschool Diarrhea/ETIOLOGY Enterocolitis, Pseudomembranous/ETIOLOGY Failure to Thrive/ETIOLOGY Female Gastrointestinal Diseases/*ETIOLOGY Human Infant Intestinal Mucosa/PATHOLOGY Male JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/KWDcomplicationsacutediseaseatrophybacterialinfections/etiologycasereportchildchild,preschooldiarrhea/etiologyenterocolitis,pseudomembranous/etiologyfailuretothrive/etiologyfemalegastrointestinaldiseases/KWDetiologyhumaninfantintestinalmucosa/pathologymalejournalarticle
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M8850446

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